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Subject Areas on Research
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Amino acid racemization reveals differential protein turnover in osteoarthritic articular and meniscal cartilages.
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Analysis of the protein products encoded by variant glucokinase transcripts via expression in bacteria.
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Basis for resistance to 3-deazaaristeromycin, an inhibitor of S-adenosylhomocysteine hydrolase, in human B-lymphoblasts.
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Biliary excretion of glycolipid in induced or inherited glucosylceramide lipidosis.
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Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site.
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Catalytic scavenging of peroxynitrite by isomeric Mn(III) N-methylpyridylporphyrins in the presence of reductants.
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Chlordanes in the indoor and outdoor air of three U.S. cities.
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Cisplatin-induced changes in sodium, chloride, and urea transport by the frog skin.
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Concerted proton transfer mechanism of Clostridium thermocellum ribose-5-phosphate isomerase.
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Coordinate changes in C protein and myosin expression during skeletal muscle hypertrophy.
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Cytochrome P450IIIA activity and cytokine-mediated synthesis of nitric oxide.
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Cytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate.
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DMT1 expression is increased in the lungs of hypotransferrinemic mice.
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Depletion of arterial L-arginine causes reversible tolerance to endothelium-dependent relaxation.
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Differential binding of apolipoprotein E isoforms to tau and other cytoskeletal proteins.
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Differential developmental toxicity of naphthoic acid isomers in medaka (Oryzias latipes) embryos.
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Differential effects of platelet-derived growth factor isotypes on human smooth muscle cell proliferation and migration are mediated by distinct signaling pathways.
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Differentiation of isomeric acylcarnitines using tandem mass spectrometry.
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Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers.
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Effect of molecular characteristics on cellular uptake, subcellular localization, and phototoxicity of Zn(II) N-alkylpyridylporphyrins.
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Effects of natural and enantiomeric cholesterol on the thermotropic phase behavior and structure of egg sphingomyelin bilayer membranes.
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Epidermal growth factor promotes uncoupling from adenylyl cyclase of the rat D2S receptor expressed in GH4C1 cells.
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Expression of amphiphysin I, an autoantigen of paraneoplastic neurological syndromes, in breast cancer.
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Force-induced prolyl cis-trans isomerization in elastin-like polypeptides.
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Genetic variation in the odorant receptor OR2J3 is associated with the ability to detect the "grassy" smelling odor, cis-3-hexen-1-ol.
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Ghrelin stimulation of growth hormone isoforms: parallel secretion of total and 20-kDa growth hormone and relation to insulin sensitivity in healthy humans.
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Heterogeneity in the phosphorylation of microtubule-associated protein MAP1B during rat brain development.
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High lipophilicity of meta Mn(III) N-alkylpyridylporphyrin-based superoxide dismutase mimics compensates for their lower antioxidant potency and makes them as effective as ortho analogues in protecting superoxide dismutase-deficient Escherichia coli.
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Hyperglycosylated human chorionic gonadotropin does not increase progesterone production by luteinized granulosa cells.
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Identification and quantification of regioisomeric cholesteryl linoleate hydroperoxides in oxidized human low density lipoprotein and high density lipoprotein.
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Identification of a novel inositol bisphosphate isomer formed in chemoattractant stimulated human polymorphonuclear leukocytes.
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Identification of sugar isomers by single-molecule force spectroscopy.
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Implausibility of the vibrational theory of olfaction.
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Increasing occurrences and functional roles for high energy purine-pyrimidine base-pairs in nucleic acids.
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Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells.
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Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.
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Interleukin-4 and interferon-gamma discordantly regulate collagen biosynthesis by functionally distinct lung fibroblast subsets.
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Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease.
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Isotopomer enrichment assay for very short chain fatty acids and its metabolic applications.
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Isotretinoin and Staphylococcus aureus infection. A possible association.
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Kinetic studies of tryptophan synthetase. Interaction of L-serine, indole, and tryptophan with the native enzyme.
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Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins.
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Local sources of retinoic acid coincide with retinoid-mediated transgene activity during embryonic development.
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Mechanistic studies of the cycloisomerization of dimethyl diallylmalonate catalyzed by a cationic palladium phenanthroline complex.
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Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N-methoxyalkylpyridylporphyrins.
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Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses.
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Mutational analysis of the coding regions of the genes encoding protein kinase B-alpha and -beta, phosphoinositide-dependent protein kinase-1, phosphatase targeting to glycogen, protein phosphatase inhibitor-1, and glycogenin: lessons from a search for genetic variability of the insulin-stimulated glycogen synthesis pathway of skeletal muscle in NIDDM patients.
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NK-1 antagonist reduces colonic inflammation and oxidative stress in dextran sulfate-induced colitis in rats.
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Naturally occurring anti-alpha-galactosyl antibodies: relationship to xenoreactive anti-alpha-galactosyl antibodies.
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Post-translational aging of proteins in osteoarthritic cartilage and synovial fluid as measured by isomerized aspartate.
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Preorganized secondary structure as an important determinant of fast protein folding.
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Racing against unwanted isomerization.
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Reactive cross-talk between adjacent tension-trapped transition states.
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Regulation of inositol phosphate metabolism in chemoattractant-stimulated human polymorphonuclear leukocytes. Definition of distinct dephosphorylation pathways for IP3 isomers.
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Relaxation spectra of aspartate transcarbamylase. Interaction of the catalytic subunit with carbamyl phosphate, succinate, and L-malate.
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Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with carbamyl phosphate.
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Selective induction of CCAAT/enhancer binding protein isoforms occurs during rat liver development.
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Selectivity and stereospecificity of the reactions of dichlorodiammineplatinum(II) with three purified plasma proteins.
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Spatial map of salts and saccharides on dog tongue.
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Specific agrin isoforms induce cAMP response element binding protein phosphorylation in hippocampal neurons.
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Stereospecificity of monoacylglycerol acyltransferase activity from rat intestine and suckling rat liver.
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Structural changes in the photoactive site of proteorhodopsin during the primary photoreaction.
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Structure and interactive properties of highly fluorinated phospholipid bilayers.
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Structure and organization of hexadecanol isomers adsorbed to the air/water interface.
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Suicide substrates for the alanine racemase of Escherichia coli B.
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Synthesis and bioactivity of carbohydrate derivatives of indigo, its isomers and heteroanalogues.
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Synthetic and mechanistic studies of the cycloisomerization and cyclization/hydrosilylation of functionalized dienes catalyzed by cationic palladium(II) complexes.
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TGF-beta regulates expression of tenascin alternative-splicing isoforms in fetal rat lung.
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The beta-adrenergic receptor and adenylate cyclase.
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The effect of ethanol on the phase transition temperature and the phase structure of monounsaturated phosphatidylcholines.
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The ortho effect makes manganese(III) meso-tetrakis(N-methylpyridinium-2-yl)porphyrin a powerful and potentially useful superoxide dismutase mimic.
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Two crystal polymorphs of a flavonoid from Melicope ellyrana.
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Valproylcarnitine: a novel drug metabolite identified by fast atom bombardment and thermospray liquid chromatography-mass spectrometry.
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Visualizing reaction pathways in photoactive yellow protein from nanoseconds to seconds.
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cTnT1, a cardiac troponin T isoform, decreases myofilament tension and affects the left ventricular pressure waveform.
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cis-dichlorodiammineplatinum (II) as a selective modifier of the oxidation-sensitive reactive-center methionine in alpha 1-antitrypsin.
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