Isomerism

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  Subject Areas on Research

  • (+/-)-cis-2-acetoxycyclobutyltrimethylammonium iodide: a semirigid analogue of acetylcholine. 
  • Amino acid racemization reveals differential protein turnover in osteoarthritic articular and meniscal cartilages. 
  • Analysis of the protein products encoded by variant glucokinase transcripts via expression in bacteria. 
  • Apolipoprotein E affects the rate of Alzheimer disease expression: beta-amyloid burden is a secondary consequence dependent on APOE genotype and duration of disease. 
  • Basis for resistance to 3-deazaaristeromycin, an inhibitor of S-adenosylhomocysteine hydrolase, in human B-lymphoblasts. 
  • Biliary excretion of glycolipid in induced or inherited glucosylceramide lipidosis. 
  • Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site. 
  • Catalytic scavenging of peroxynitrite by isomeric Mn(III) N-methylpyridylporphyrins in the presence of reductants. 
  • Chlordanes in the indoor and outdoor air of three U.S. cities. 
  • Cisplatin-induced changes in sodium, chloride, and urea transport by the frog skin. 
  • Concerted proton transfer mechanism of Clostridium thermocellum ribose-5-phosphate isomerase. 
  • Coordinate changes in C protein and myosin expression during skeletal muscle hypertrophy. 
  • Cytochrome P450IIIA activity and cytokine-mediated synthesis of nitric oxide. 
  • Cytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate. 
  • DMT1 expression is increased in the lungs of hypotransferrinemic mice. 
  • Depletion of arterial L-arginine causes reversible tolerance to endothelium-dependent relaxation. 
  • Differential binding of apolipoprotein E isoforms to tau and other cytoskeletal proteins. 
  • Differential developmental toxicity of naphthoic acid isomers in medaka (Oryzias latipes) embryos. 
  • Differential effects of platelet-derived growth factor isotypes on human smooth muscle cell proliferation and migration are mediated by distinct signaling pathways. 
  • Differentiation of isomeric acylcarnitines using tandem mass spectrometry. 
  • Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers. 
  • Effect of molecular characteristics on cellular uptake, subcellular localization, and phototoxicity of Zn(II) N-alkylpyridylporphyrins. 
  • Effects of natural and enantiomeric cholesterol on the thermotropic phase behavior and structure of egg sphingomyelin bilayer membranes. 
  • Epidermal growth factor promotes uncoupling from adenylyl cyclase of the rat D2S receptor expressed in GH4C1 cells. 
  • Expression of amphiphysin I, an autoantigen of paraneoplastic neurological syndromes, in breast cancer. 
  • Force-induced prolyl cis-trans isomerization in elastin-like polypeptides. 
  • Genetic variation in the odorant receptor OR2J3 is associated with the ability to detect the "grassy" smelling odor, cis-3-hexen-1-ol. 
  • Ghrelin stimulation of growth hormone isoforms: parallel secretion of total and 20-kDa growth hormone and relation to insulin sensitivity in healthy humans. 
  • High lipophilicity of meta Mn(III) N-alkylpyridylporphyrin-based superoxide dismutase mimics compensates for their lower antioxidant potency and makes them as effective as ortho analogues in protecting superoxide dismutase-deficient Escherichia coli. 
  • Hyperglycosylated human chorionic gonadotropin does not increase progesterone production by luteinized granulosa cells. 
  • II. Pharmacological studies with derivatives of 2-aminotetralin, benzhydro[f]quinoline, benzhydro[g]quinoline, apomorphine and clonidine suggest a pharmacological dissimilarity between peripheral presynaptic dopamine receptors and alpha-2 adrenoceptors. 
  • Identification and quantification of regioisomeric cholesteryl linoleate hydroperoxides in oxidized human low density lipoprotein and high density lipoprotein. 
  • Identification of a novel inositol bisphosphate isomer formed in chemoattractant stimulated human polymorphonuclear leukocytes. 
  • Identification of sugar isomers by single-molecule force spectroscopy. 
  • Implausibility of the vibrational theory of olfaction. 
  • Increasing occurrences and functional roles for high energy purine-pyrimidine base-pairs in nucleic acids. 
  • Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells. 
  • Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2. 
  • Interleukin-4 and interferon-gamma discordantly regulate collagen biosynthesis by functionally distinct lung fibroblast subsets. 
  • Isoform-specific induction of a retinoid-responsive antigen after biolistic transfection of chimaeric retinoic acid/thyroid hormone receptors into a regenerating limb. 
  • Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease. 
  • Isofurans, but not F2-isoprostanes, are increased in the substantia nigra of patients with Parkinson's disease and with dementia with Lewy body disease. 
  • Isotopomer enrichment assay for very short chain fatty acids and its metabolic applications. 
  • Isotretinoin and Staphylococcus aureus infection. A possible association. 
  • Kinetic studies of tryptophan synthetase. Interaction of L-serine, indole, and tryptophan with the native enzyme. 
  • Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins. 
  • Local sources of retinoic acid coincide with retinoid-mediated transgene activity during embryonic development. 
  • Mechanistic studies of the cycloisomerization of dimethyl diallylmalonate catalyzed by a cationic palladium phenanthroline complex. 
  • Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N-methoxyalkylpyridylporphyrins. 
  • Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses. 
  • Mutational analysis of the coding regions of the genes encoding protein kinase B-alpha and -beta, phosphoinositide-dependent protein kinase-1, phosphatase targeting to glycogen, protein phosphatase inhibitor-1, and glycogenin: lessons from a search for genetic variability of the insulin-stimulated glycogen synthesis pathway of skeletal muscle in NIDDM patients. 
  • NK-1 antagonist reduces colonic inflammation and oxidative stress in dextran sulfate-induced colitis in rats. 
  • Naturally occurring anti-alpha-galactosyl antibodies: relationship to xenoreactive anti-alpha-galactosyl antibodies. 
  • Organization of the inter-alpha-inhibitor heavy chains on the chondroitin sulfate originating from Ser(10) of bikunin: posttranslational modification of IalphaI-derived bikunin. 
  • Phosphoaspirin (MDC-43), a novel benzyl ester of aspirin, inhibits the growth of human cancer cell lines more potently than aspirin: a redox-dependent effect. 
  • Post-translational aging of proteins in osteoarthritic cartilage and synovial fluid as measured by isomerized aspartate. 
  • Preorganized secondary structure as an important determinant of fast protein folding. 
  • Reactive cross-talk between adjacent tension-trapped transition states. 
  • Regulation of inositol phosphate metabolism in chemoattractant-stimulated human polymorphonuclear leukocytes. Definition of distinct dephosphorylation pathways for IP3 isomers. 
  • Relaxation spectra of aspartate transcarbamylase. Interaction of the catalytic subunit with carbamyl phosphate, succinate, and L-malate. 
  • Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with carbamyl phosphate. 
  • Selective induction of CCAAT/enhancer binding protein isoforms occurs during rat liver development. 
  • Selectivity and stereospecificity of the reactions of dichlorodiammineplatinum(II) with three purified plasma proteins. 
  • Spatial map of salts and saccharides on dog tongue. 
  • Specific agrin isoforms induce cAMP response element binding protein phosphorylation in hippocampal neurons. 
  • Stereospecificity of monoacylglycerol acyltransferase activity from rat intestine and suckling rat liver. 
  • Structural changes in the photoactive site of proteorhodopsin during the primary photoreaction. 
  • Structure and interactive properties of highly fluorinated phospholipid bilayers. 
  • Structure and organization of hexadecanol isomers adsorbed to the air/water interface. 
  • Suicide substrates for the alanine racemase of Escherichia coli B. 
  • Synthesis and bioactivity of carbohydrate derivatives of indigo, its isomers and heteroanalogues. 
  • Synthetic and mechanistic studies of the cycloisomerization and cyclization/hydrosilylation of functionalized dienes catalyzed by cationic palladium(II) complexes. 
  • TGF-beta regulates expression of tenascin alternative-splicing isoforms in fetal rat lung. 
  • The beta-adrenergic receptor and adenylate cyclase. 
  • The effect of ethanol on the phase transition temperature and the phase structure of monounsaturated phosphatidylcholines. 
  • The ortho effect makes manganese(III) meso-tetrakis(N-methylpyridinium-2-yl)porphyrin a powerful and potentially useful superoxide dismutase mimic. 
  • Two crystal polymorphs of a flavonoid from Melicope ellyrana. 
  • Two sites of action for synapsin domain E in regulating neurotransmitter release. 
  • Valproylcarnitine: a novel drug metabolite identified by fast atom bombardment and thermospray liquid chromatography-mass spectrometry. 
  • Visualizing reaction pathways in photoactive yellow protein from nanoseconds to seconds. 
  • cTnT1, a cardiac troponin T isoform, decreases myofilament tension and affects the left ventricular pressure waveform. 
  • cis-dichlorodiammineplatinum (II) as a selective modifier of the oxidation-sensitive reactive-center methionine in alpha 1-antitrypsin. 
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  Keywords of People

  • Ferreira, Paulo Alexandre, Associate Professor in Ophthalmology, Pathology
  • Warner, David Samuel, Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology