Isoproterenol

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  Subject Areas on Research

  • (3H)-Propranolol binding sites in myocardial membranes: nonidentity with beta adrenergic receptors. 
  • (3H)norepinephrine binding and lipolysis by isolated fat cells. 
  • A central role for beta-arrestins and clathrin-coated vesicle-mediated endocytosis in beta2-adrenergic receptor resensitization. Differential regulation of receptor resensitization in two distinct cell types. 
  • A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated. 
  • A desensitized state of the beta adrenergic receptor not associated with high-affinity agonist occupancy. 
  • A fraction of the ventricular myocardium that has the specificity of the cardiac beta-adrenergic receptor. 
  • A high affinity agonist . beta-adrenergic receptor complex is an intermediate for catecholamine stimulation of adenylate cyclase in turkey and frog erythrocyte membranes. 
  • A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration. 
  • A mutation of the beta 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. Distinct molecular determinants of the receptor are involved in physical coupling to and functional activation of Gs. 
  • A novel catecholamine-activated adenosine cyclic 3',5'-phosphate independent pathway for beta-adrenergic receptor phosphorylation in wild-type and mutant S49 lymphoma cells: mechanism of homologous desensitization of adenylate cyclase. 
  • A reconstitution assay for the guanine nucleotide regulatory protein of the adenylate cyclase system using turkey erythrocyte membranes as the acceptor preparation. 
  • A role for Ni in the hormonal stimulation of adenylate cyclase. 
  • A small region of the beta-adrenergic receptor is selectively involved in its rapid regulation. 
  • A systems genetics approach identifies Trp53inp2 as a link between cardiomyocyte glucose utilization and hypertrophic response. 
  • A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor. 
  • Accentuated vagal antagonism of beta-adrenergic effects on ventricular repolarization. Evidence of weaker antagonism in hostile type A men. 
  • Activation and desensitization of beta-adrenergic receptor-coupled GTPase and adenylate cyclase of frog and turkey erythrocyte membranes. 
  • Activation of adenylate cyclase by beta-adrenergic receptors: investigation of rate limiting steps by simultaneous assay of high affinity agonist binding and GDP release. 
  • Activation of adenylate cyclase by phosphoramidate and phosphonate analogs of GTP: possible role of covalent enzyme-substrate intermediates in the mechanism of hormonal activation. 
  • Activation, desensitization, and recycling of frog erythrocyte beta-adrenergic receptors. Differential perturbation by in situ trypsinization. 
  • Adipocyte beta-adrenergic receptors. Identification and subcellular localization by (-)-[3H]dihydroalprenolol binding. 
  • Adolescent nicotine administration alters serotonin receptors and cell signaling mediated through adenylyl cyclase. 
  • Adolescent nicotine administration changes the responses to nicotine given subsequently in adulthood: adenylyl cyclase cell signaling in brain regions during nicotine administration and withdrawal, and lasting effects. 
  • Adolescent nicotine exposure alters cardiac autonomic responsiveness: beta-adrenergic and m2-muscarinic receptors and their linkage to adenylyl cyclase. 
  • Adrenergic control of DNA synthesis in developing rat brain regions: effects of intracisternal administration of isoproterenol. 
  • Adrenergic desensitization in left ventricle from streptozotocin diabetic swine. 
  • Adrenergic receptors in the heart. 
  • Adrenergic receptors: molecular mechanisms of clinically relevant regulation. 
  • Age-associated differences in beta adrenergic-stimulated lipolysis in adipocytes from Sprague-Dawley and Fischer 344 rats. 
  • Agonist-induced increase in apparent beta-adrenergic receptor size. 
  • Agonist-induced sensitization of beta-adrenoceptor signaling in neonatal rat heart: expression and catalytic activity of adenylyl cyclase. 
  • Agonist-promoted high affinity state of the beta-adrenergic receptor in human neutrophils: modulation by corticosteroids. 
  • Agonist-stimulated beta-adrenergic receptor internalization requires dynamic cytoskeletal actin turnover. 
  • Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. 
  • Alpha-adrenergic receptors in rat myocardium. Identification by binding of [3H]dihydroergocryptine. 
  • Alteration of ventricular fibrillation by propranolol and isoproterenol detected by epicardial mapping with 506 electrodes. 
  • Altered genetic response to beta-adrenergic receptor activation in late passage C6 glioma cells. 
  • Altered patterns of agonist-stimulated cAMP accumulation in cells expressing mutant beta 2-adrenergic receptors lacking phosphorylation sites. 
  • Analysis of pulsatile pulmonary artery blood flow in the unanesthetized dog. 
  • Androgen receptor activation by G(s) signaling in prostate cancer cells. 
  • Androgens amplify beta-adrenergic and FSH stimulation of granulosa cells. 
  • Are developing beta-adrenoceptors able to desensitize? Acute and chronic effects of beta-agonists in neonatal heart and liver. 
  • Association of sequestered beta-adrenergic receptors with the plasma membrane: a novel mechanism for receptor down regulation. 
  • Atypical regulation of hepatic adenylyl cyclase and adrenergic receptors during a critical developmental period: agonists evoke supersensitivity accompanied by failure of receptor down-regulation. 
  • Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice. 
  • Autonomic mechanisms of training bradycardia: beta-adrenergic receptors in humans. 
  • Autoradiographic localization of ornithine decarboxylase in cerebellar cortex of the developing rat with [3H]alpha-difluoromethylornithine. 
  • Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation. 
  • Beta 2-adrenergic receptor stimulated, G protein-coupled receptor kinase 2 mediated, phosphorylation of ribosomal protein P2. 
  • Beta adrenergic control of macromolecule synthesis in neonatal rat heart, kidney and lung: relationship to sympathetic neuronal development. 
  • Beta adrenergic receptors in lymphocyte subpopulations. 
  • Beta adrenergic stimulation of protein carboxymethylation and amylase secretion in rat parotid gland. 
  • Beta(2)-adrenergic and several other G protein-coupled receptors in human atrial membranes activate both G(s) and G(i). 
  • Beta-Adrenergic receptors of human lymphocytes are unaltered by hyperthyroidism. 
  • Beta-adrenergic control of c-fos expression in fetal and neonatal rat tissues: relationship to cell differentiation and teratogenesis. 
  • Beta-adrenergic inhibition of cardiac sodium channels by dual G-protein pathways. 
  • Beta-adrenergic receptor overexpression in the fetal rat: distribution, receptor subtypes, and coupling to adenylate cyclase activity via G-proteins. 
  • Beta-adrenergic receptor sequestration. A potential mechanism of receptor resensitization. 
  • Beta-adrenergic receptors: biochemical mechanisms of physiological regulation. 
  • Beta-adrenoceptor control of G protein function in the neonate: determinant of desensitization or sensitization. 
  • Beta-adrenoceptor control of cardiac adenylyl cyclase during development: agonist pretreatment in the neonate uniquely causes heterologous sensitization, not desensitization. 
  • Beta-adrenoceptor signaling and its control of cell replication in MDA-MB-231 human breast cancer cells. 
  • Beta-adrenoceptor-mediated cell signaling in the neonatal heart and liver: responses to terbutaline. 
  • Beta-adrenoreceptors determine affinity but not intrinsic activity of adenylate cyclase stimulants. 
  • Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors. 
  • Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. 
  • Beta1-adrenergic receptors maintain fetal heart rate and survival. 
  • Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction. 
  • Beta2-adrenergic receptor lysosomal trafficking is regulated by ubiquitination of lysyl residues in two distinct receptor domains. 
  • Binding of catecholamines to receptors in cultured myocardial cells. 
  • Binding of the beta2 adrenergic receptor to N-ethylmaleimide-sensitive factor regulates receptor recycling. 
  • Biochemical characterization of the beta-adrenergic receptor of the frog erythrocyte. 
  • Biological activity of agarose-immobilized catecholamines. 
  • Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. 
  • Cardiac output by impedance cardiography: two alternative methodologies compared with thermodilution. 
  • Cardiac-specific LIM protein FHL2 modifies the hypertrophic response to beta-adrenergic stimulation. 
  • Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury. 
  • Catecholamine binding to the beta-adrenergic receptor. 
  • Catecholamine stimulated myocardial adenylate cyclase: effects of nucleotides. 
  • Catecholamine stimulated myocardial adenylate cyclase: effects of phospholipase digestion and the role of membrane lipids. 
  • Catecholamine-induced desensitization in turkey erythrocytes: cAMP mediated impairment of high affinity agonist binding without alteration in receptor number. 
  • Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor. 
  • Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase. Structural alterations in the beta-adrenergic receptor revealed by photoaffinity labeling. 
  • Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptor binding sites. 
  • Cell-free desensitization of catecholamine-sensitive adenylate cyclase. Agonist- and cAMP-promoted alterations in turkey erythrocyte beta-adrenergic receptors. 
  • Cellular and molecular alterations in the beta adrenergic system with cardiomyopathy induced by tachycardia. 
  • Characteristics of 5'-guanylyl imidodiphosphate-activated adenylate cyclase. 
  • Characterization of the statin-like S1 and rat elongation factor 1 alpha as two distinctly expressed messages in rat. 
  • Chemoattractant-elicited alterations of cAMP levels in human polymorphonuclear leukocytes require a Ca2+-dependent mechanism which is independent of transmembrane activation of adenylate cyclase. 
  • Chronic estrogen treatment decreases beta-adrenergic responses in rat cerebral cortex. 
  • Chronic ethanol treatment increases expression of inhibitory G-proteins and reduces adenylylcyclase activity in the central nervous system of two lines of ethanol-sensitive mice. 
  • Chronic guanethidine treatment increases cardiac beta-adrenergic receptors. 
  • Ciba-Geigy award for outstanding research. Regulation of adrenergic receptor function by phosphorylation. 
  • Cocaine and beta-adrenergic receptor function in pregnant myometrium. 
  • Cocaine downregulates beta-adrenergic receptors in pregnant sheep myometrium. 
  • Cocaine selectively inhibits beta-adrenergic receptor binding in pregnant human myometrium. 
  • Comparative rates of desensitization of beta-adrenergic receptors by the beta-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase. 
  • Comparison of specificity of agonist and antagonist radioligand binding to beta adrenergic receptors. 
  • Consequences of growth hormone deficiency on cardiac structure, function, and beta-adrenergic pathway: studies in mutant dwarf rats. 
  • Control of adenylate cyclase activity in developing rat heart and liver: effects of prenatal exposure to terbutaline or dexamethasone. 
  • Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice. 
  • Correlation of beta-adrenergic receptor-stimulated [3H]GDP release and adenylate cyclase activation. Differences between frog and turkey erythrocyte membranes. 
  • Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes. 
  • Critical periods for chlorpyrifos-induced developmental neurotoxicity: alterations in adenylyl cyclase signaling in adult rat brain regions after gestational or neonatal exposure. 
  • Cultured glomerular mesangial cells contain renin: influence of calcium and isoproterenol. 
  • Cyclic mechanical stress and trabecular meshwork cell contractility. 
  • Cyclic nucleotides regulate the morphologic alterations required for chemotaxis in monocytes. 
  • DNA Methylation Indicates Susceptibility to Isoproterenol-Induced Cardiac Pathology and Is Associated With Chromatin States. 
  • Decreased beta-adrenergic responses in the female rat brain are eliminated by ovariectomy: correlation of [3H]dihydroalprenolol binding and catecholamine stimulated cyclic AMP levels. 
  • Decreased beta-adrenergic responsiveness following hypertrophy occurs only in cardiomyocytes that also re-express beta-myosin heavy chain. 
  • Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation. 
  • Desensitization of beta-adrenergic receptors by beta-adrenergic agonists in a cell-free system: resensitization by guanosine 5'-(beta, gamma-imino)triphosphate and other purine nucleotides. 
  • Desensitization of beta-adrenergic stimulated adenylate cyclase in turkey erythrocytes. 
  • Desensitization of myocardial beta-adrenergic receptors and deterioration of left ventricular function after brain death. 
  • Desensitization of the beta-adrenergic receptor of frog erythrocytes. Recovery and characterization of the down-regulated receptors in sequestered vesicles. 
  • Desensitization of the turkey erythrocyte beta-adrenergic receptor in a cell-free system. Evidence that multiple protein kinases can phosphorylate and desensitize the receptor. 
  • Desensitization of turkey erythrocyte adenylate cyclase. Beta-adrenergic receptor phosphorylation is correlated with attenuation of adenylate cyclase activity. 
  • Development of the linkage of beta-adrenergic receptors to cardiac hypertrophy and heart rate control: neonatal sympathectomy with 6-hydroxydopamine. 
  • Developmental exposure to terbutaline alters cell signaling in mature rat brain regions and augments the effects of subsequent neonatal exposure to the organophosphorus insecticide chlorpyrifos. 
  • Differences between agonist and antagonist binding following beta-adrenergic receptor desensitization. 
  • Differential effects of GTP on the coupling of beta-adrenergic receptors to adenylate cyclase from frog and turkey erythrocytes. Application of new methods for the analysis of receptor-effector coupling. 
  • Differential effects of cholera toxin on guanine nucleotide regulation of beta-adrenergic agonist high affinity binding and adenylate cyclase activation in frog erythrocyte membranes. 
  • Differential regulation of cAMP by endogenous versus transfected formylpeptide chemoattractant receptors: implications for Gi-coupled receptor signaling. 
  • Differential regulation of proteasome function in isoproterenol-induced cardiac hypertrophy. 
  • Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation. 
  • Direct demonstration of impaired functionality of a purified desensitized beta-adrenergic receptor in a reconstituted system. 
  • Direct identification and characterisation of beta-adrenergic receptors in rat brain. 
  • Direct studies of beta-adrenergic receptors intact frog erythrocytes. 
  • Distinct roles for β-arrestin2 and arrestin-domain-containing proteins in β2 adrenergic receptor trafficking. 
  • Dose-dependent effect of prenatal dexamethasone treatment on beta-adrenergic receptor coupling to ornithine decarboxylase and cyclic AMP. 
  • Dual inhibition of beta-adrenergic and angiotensin II receptors by a single antagonist: a functional role for receptor-receptor interaction in vivo. 
  • Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function. 
  • Editorial: Selectivity in beta-adrenergic responses: clinical implications. 
  • Effect of pertussis toxin on alpha 2-adrenoceptors: decreased formation of the high-affinity state for agonists. 
  • Effects of diazoxide and beta adrenergic drugs on spontaneous and induced uterine activity in the pregnant baboon. 
  • Effects of fetal dexamethasone exposure on postnatal control of cardiac adenylate cyclase: beta-adrenergic receptor coupling to Gs regulatory protein. 
  • Effects of local anesthetics on guanyl nucleotide modulation of the catecholamine-sensitive adenylate cyclase system and on beta-adrenergic receptors. 
  • Effects of neonatal treatment with 6-aminonicotinamide on basal and isoproterenol-stimulated ornithine decarboxylase activity in cerebellum of the development rat. 
  • Effects of neurochemicals upon a dinoflagellate photoresponse. 
  • Effects of propranolol treatment on left ventricular function and intracellular calcium regulation in rats with postinfarction heart failure. 
  • Electrophysiology and Arrhythmogenesis in the Human Right Ventricular Outflow Tract. 
  • Endogenous proteinases modulate the function of the beta-adrenergic receptor-adenylate cyclase system. 
  • Endothelial renin-angiotensin pathway. Adrenergic regulation of angiotensin secretion. 
  • Endothelin activates voltage-dependent Ca2+ current by a G protein-dependent mechanism in rabbit cardiac myocytes. 
  • Enhanced adenylate cyclase activity of turkey erythrocytes following treatment with beta-adrenergic receptor antagonists. 
  • Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* protein. 
  • Enhanced cardiac function in transgenic mice expressing a Ca(2+)-stimulated adenylyl cyclase. 
  • Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor. 
  • Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery. 
  • Evaluation of several methods for computing stroke volume from central aortic pressure. 
  • Exercise-induced functional desensitization of canine cardiac beta-adrenergic receptors. 
  • Expression of a human cDNA encoding the beta 2-adrenergic receptor in Chinese hamster fibroblasts (CHW): functionality and regulation of the expressed receptors. 
  • Expression of cDNAs for G proteins in Escherichia coli. Two forms of Gs alpha stimulate adenylate cyclase. 
  • Fetal nicotine exposure produces postnatal up-regulation of adenylate cyclase activity in peripheral tissues. 
  • Functional activity and regulation of human beta 2-adrenergic receptors expressed in Xenopus oocytes. 
  • Functional consequences of prenatal methylmercury exposure: effects on renal and hepatic responses to trophic stimuli and on renal excretory mechanisms. 
  • Functional differences in the beta gamma complexes of transducin and the inhibitory guanine nucleotide regulatory protein. 
  • Functional integrity of desensitized beta-adrenergic receptors. 
  • G Protein-Coupled Receptor Endocytosis Confers Uniformity in Responses to Chemically Distinct Ligands. 
  • G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation. 
  • G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95. 
  • G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer. 
  • Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model. 
  • Genetic Regulation of Fibroblast Activation and Proliferation in Cardiac Fibrosis. 
  • Glucocorticoid therapy in sepsis/shock caused by gram-negative microorganisms. 
  • Glucocorticoid-targeting of the adenylyl cyclase signaling pathway in the cerebellum of young vs. aged rats. 
  • Guanine nucleotides and alpha 1 adrenergic receptors in the heart. 
  • HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy. 
  • Haplo-insufficiency of Bcl2-associated athanogene 3 in mice results in progressive left ventricular dysfunction, β-adrenergic insensitivity, and increased apoptosis. 
  • Hemodynamic evaluation of glucagon in symptomatic heart disease. 
  • Hemodynamic evaluation of rate augmentation produced by atrial pacing and isoproterenol in the early postoperative phase of cardiac valve surgery. 
  • Hepatic cyclic AMP generation and ornithine decarboxylase induction by glucagon and beta adrenergic agonists. 
  • Heroin neuroteratogenicity: targeting adenylyl cyclase as an underlying biochemical mechanism. 
  • Heterologous desensitization of the inhibitory A1 adenosine receptor-adenylate cyclase system in rat adipocytes. Regulation of both Ns and Ni. 
  • High spinal anesthesia for cardiac surgery: effects on beta-adrenergic receptor function, stress response, and hemodynamics. 
  • Homologous desensitization of adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor. 
  • Homologous desensitization of beta-adrenergic receptor coupled adenylate cyclase. Resensitization by polyethylene glycol treatment. 
  • Hostility and adrenergic receptor responsiveness: evidence of reduced beta-receptor responsiveness in high hostile men. 
  • Hostility is related to blunted beta-adrenergic receptor responsiveness among middle-aged women. 
  • Hostility, social support, and adrenergic receptor responsiveness among African-American and white men and women. 
  • Hypothyroidism modulates beta adrenergic receptor adenylate cyclase interactions in rat reticulocytes. 
  • Identification and regulation of alpha- and beta-adrenergic receptors. 
  • Identification of adenylate cyclase-coupled beta-adrenergic receptors in frog erythrocytes with (minus)-[3-H] alprenolol. 
  • Identification of adenylate cyclase-coupled beta-adrenergic receptors with radiolabeled beta-adrenergic antagonists. 
  • Identification of beta-adrenergic receptors in human lymphocytes by (-) (3H) alprenolol binding. 
  • Identification of cardiac beta-adrenergic receptors by (minus) [3H]alprenolol binding. 
  • Imbalances emerge in cardiac autonomic cell signaling after neonatal exposure to terbutaline or chlorpyrifos, alone or in combination. 
  • Impact of Racial Discrimination and Hostility on Adrenergic Receptor Responsiveness in African American Adults. 
  • Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice. 
  • In vitro desensitization of beta adrenergic receptors in human neutrophils. Attenuation by corticosteroids. 
  • In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function. 
  • Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors. 
  • Inhibition of cardiac Na+ currents by isoproterenol. 
  • Inhibition of microglial superoxide anion production by isoproterenol and dexamethasone. 
  • Inhibition of receptor-localized PI3K preserves cardiac beta-adrenergic receptor function and ameliorates pressure overload heart failure. 
  • Internal trafficking and surface mobility of a functionally intact beta2-adrenergic receptor-green fluorescent protein conjugate. 
  • Intracoronary adenovirus-mediated delivery and overexpression of the beta(2)-adrenergic receptor in the heart : prospects for molecular ventricular assistance. 
  • Intrahepatic glucose: a requirement for neonatal ODC induction by specific hormones. 
  • Intrinsic cardiac muscle function, calcium handling and beta -adrenergic responsiveness is impaired in rats with growth hormone deficiency. 
  • Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor. 
  • Irreversible activation of adenylate cyclase of toad erythrocyte plasma membrane by 5'-guanylylimidodiphosphate. 
  • Irreversible stimulation of adenylate cyclase activity of fat cell membranes of phosphoramidate and phosphonate analogs of GTP. 
  • Isolation and characterization of the beta-adrenergic receptor of frog erythrocytes and development of potential affinity ligands. 
  • Isoproterenol downregulation of statin-related gene expression in the rat parotid gland. 
  • Isoproterenol inhibits the increase in microvascular membrane permeability produced by bradykinin. 
  • Kinetics of irreversible activation of adenylate cyclase of fat cell membranes by phosphonium and phosphoramidate analogs of gtp1. 
  • Left atrial tachycardia originating from the mitral annulus-aorta junction. 
  • Ligand-induced overexpression of a constitutively active beta2-adrenergic receptor: pharmacological creation of a phenotype in transgenic mice. 
  • Light-dependent phosphorylation of rhodopsin by beta-adrenergic receptor kinase. 
  • Mapping genetic contributions to cardiac pathology induced by Beta-adrenergic stimulation in mice. 
  • Maturation of sympathetic neurotransmission in the rat heart. IX. Development of transsynaptic regulation of cardiac adrenergic sensitivity. 
  • Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling. 
  • Mechanism of action of Vibrio cholerae enterotoxin. Effects on adenylate cyclase of toad and rat erythrocyte plasma membranes. 
  • Mechanism of activation of adenylate cyclase by Vibrio cholerae enterotoxin. Relations to the mode of activation by hormones. 
  • Mechanism of guanine nucleotide regulatory protein-mediated inhibition of adenylate cyclase. Studies with isolated subunits of transducin in a reconstituted system. 
  • Modeling of sequestration and down regulation in cells containing beta2-adrenergic receptors. 
  • Modulation of in vivo cardiac function by myocyte-specific nitric oxide synthase-3. 
  • Molecular pharmacology of adenylate cyclase-coupled alpha- and beta-adrenergic receptors. 
  • Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases. 
  • Multiple effects of N, N' dicyclohexyl carbodiimide on the beta-adrenergic receptor--adenylate cyclase system in frog erythrocytes. 
  • Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors. 
  • Multiple reactive sulfhydryl groups modulate the function of adenylate cyclase coupled beta-adrenergic receptors. 
  • Myocardial beta-adrenergic receptor signaling in vivo: insights from transgenic mice. 
  • Myocardial beta-adrenergic receptors from adrenalectomized rats: impaired formation of high-affinity agonist-receptor complexes. 
  • Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs. 
  • N omega-nitro-L-arginine methyl ester selectively inhibits pulmonary vasodilator responses to acetylcholine and bradykinin. 
  • Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor. 
  • Neonatal chlorpyrifos exposure targets multiple proteins governing the hepatic adenylyl cyclase signaling cascade: implications for neurotoxicity. 
  • Neonatal nutritional deprivation or enhancement: the cardiac-sympathetic axis and its role in cardiac growth and stress responses. 
  • Neonatal polyamine depletion by alpha-difluoromethylornithine: effects on adenylyl cyclase cell signaling are separable from effects on brain region growth. 
  • Neonatal rat pinealocytes: typical and atypical characteristics of [125I]iodohydroxybenzylpindolol binding and adenosine 3',5'-monophosphate accumulation. 
  • Neuronal localization of the enhanced adenylate cyclase responsiveness to catecholamines in the rat cerebral cortex following reserpine injections. 
  • Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms. 
  • Novel regulation of cardiac force-frequency relation by CREM (cAMP response element modulator). 
  • Novel vascular effects of isoprenaline following pacing-induced heart failure in the dog. 
  • Ontogeny of G-protein expression: control by beta-adrenoceptors. 
  • Ontogeny of beta-adrenoceptor/adenylyl cyclase desensitization mechanisms: the role of neonatal innervation. 
  • Ontogeny of cardiac beta-adrenoceptor desensitization mechanisms: agonist treatment enhances receptor/G-protein transduction rather than eliciting uncoupling. 
  • Ontogeny of food deprivation effects on ornithine decarboxylase: ornithine decarboxylase induction by alpha and beta agonists. 
  • Ontogeny of regulatory mechanisms for beta-adrenoceptor control of rat cardiac adenylyl cyclase: targeting of G-proteins and the cyclase catalytic subunit. 
  • Optical coding of mammalian cells using semiconductor quantum dots. 
  • Overexpression of alpha 2-adrenergic receptors in fetal rat heart: receptors in search of a function. 
  • Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors. 
  • Overexpression of pp60c-src is associated with altered regulation of adenylyl cyclase. 
  • Parallel modulation of catecholamine activation of adenylate cyclase and formation of the high-affinity agonist.receptor complex in turkey erythrocyte membranes by temperature and cis-vaccenic acid. 
  • Paroxysmal hypotension associated with sympathetic withdrawal. A new disorder of autonomic vasomotor regulation. 
  • Pharmacological activity of nitroxide analogues of dichloroisoproterenol and propranolol. 
  • Phorbol diester treatment promotes enhanced adenylate cyclase activity in frog erythrocytes. 
  • Phorbol diesters promote beta-adrenergic receptor phosphorylation and adenylate cyclase desensitization in duck erythrocytes. 
  • Phorbol esters enhance neurotransmitter-stimulated cyclic AMP production in rat brain slices. 
  • Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex. 
  • Phosphorylation of Src by phosphoinositide 3-kinase regulates beta-adrenergic receptor-mediated EGFR transactivation. 
  • Phosphorylation of beta-arrestin2 regulates its function in internalization of beta(2)-adrenergic receptors. 
  • Phosphorylation of the beta-adrenergic receptor accompanies catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase. 
  • Phosphorylation of the beta-adrenergic receptor in intact cells: relationship to heterologous and homologous mechanisms of adenylate cyclase desensitization. 
  • Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein. 
  • Phosphorylation sites on two domains of the beta 2-adrenergic receptor are involved in distinct pathways of receptor desensitization. 
  • Phosphorylation/dephosphorylation of the beta-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution. 
  • Physiological responses to catecholamine infusions in type A and type B men. 
  • Potentiation of beta-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes. 
  • Predictors of positive head-up tilt test in patients with suspected neurocardiogenic syncope or presyncope. 
  • Pregnancy and estradiol modulate myometrial G-protein pathways in the guinea pig. 
  • Prenatal dexamethasone administration disrupts the pattern of cellular development in rat lung. 
  • Prenatal nicotine exposure impairs beta-adrenergic function: persistent chronotropic subsensitivity despite recovery from deficits in receptor binding. 
  • Presynaptic and postsynaptic contributions to ontogeny of sympathetic control of heart rate in the pre-weanling rat. 
  • Prevention of bedrest-induced physical deconditioning by daily dobutamine infusions. Implications for drug-induced physical conditioning. 
  • Prolonged exercise alters beta-adrenergic responsiveness in healthy sedentary humans. 
  • Prolonged exercise alters cardiac chronotropic responsiveness in endurance athletes. 
  • Promotional role for glucocorticoids in the development of intracellular signalling: enhanced cardiac and renal adenylate cyclase reactivity to beta-adrenergic and non-adrenergic stimuli after low-dose fetal dexamethasone exposure. 
  • Promotional role for glucocorticoids in the development of intracellular signalling: enhanced cardiac and renal adenylate cyclase reactivity to beta-adrenergic and non-adrenergic stimuli after low-dose fetal dexamethasone exposure. 
  • Protection from experimental asthma by an endogenous bronchodilator. 
  • Protein kinase A, cytosolic calcium, and phosphate uptake in human proximal renal cells. 
  • Protein kinetic signatures of the remodeling heart following isoproterenol stimulation. 
  • Pulmonary hypertension and sleep apnea. 
  • Pulmonary vasodilator responses to RP 52891 are mediated by activation of a glibenclamide-sensitive K+ATP channel. 
  • Pure beta-adrenergic receptor: the single polypeptide confers catecholamine responsiveness to adenylate cyclase. 
  • Race and sex differences in cardiovascular α-adrenergic and β-adrenergic receptor responsiveness in men and women with high blood pressure. 
  • Receptor and G betagamma isoform-specific interactions with G protein-coupled receptor kinases. 
  • Reconstitution of a hormone-sensitive adenylate cyclase system. The pure beta-adrenergic receptor and guanine nucleotide regulatory protein confer hormone responsiveness on the resolved catalytic unit. 
  • Reduced beta 2-receptor mediated vasodilation in African Americans. 
  • Regulation of adenylate cyclase coupled beta-adrenergic receptors by beta-adrenergic catecholamines. 
  • Regulation of adenylate cyclase coupled beta-adrenergic receptors. 
  • Regulation of adenylate cyclase-coupled beta adrenergic receptor binding sites by beta adrenergic catecholamines in vitro. 
  • Regulation of beta-adrenergic receptors by guanyl-5'-yl imidodiphosphate and other purine nucleotides. 
  • Regulation of cardiac nitric oxide signaling by nuclear β-adrenergic and endothelin receptors. 
  • Regulation of epidermal growth factor receptor internalization by G protein-coupled receptors. 
  • Regulation of neonatal rat lung compliance by beta-adrenergic receptor stimulation: effects of prenatal exposure to terbutaline or dexamethasone. 
  • Regulation of postnatal beta-adrenergic receptor/adenylate cyclase development by prenatal agonist stimulation and steroids: alterations in rat kidney and lung after exposure to terbutaline or dexamethasone. 
  • Regulation of protein kinase inhibitor by follicle-stimulating hormone in Sertoli cells in vitro. 
  • Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. 
  • Regulation of the beta-adrenergic receptor by methylation of membrane phospholipids. 
  • Removal of phosphorylation sites from the beta 2-adrenergic receptor delays onset of agonist-promoted desensitization. 
  • Response to cardiac sympathetic activation in transgenic mice overexpressing beta 2-adrenergic receptor. 
  • Responses to propofol in the pulmonary vascular bed of the rat. 
  • Responsiveness to alpha- and beta-adrenergic receptor agonists. Effects of race in borderline hypertensive compared to normotensive men. 
  • Restoration of beta-adrenergic receptor signaling and contractile function in heart failure by disruption of the betaARK1/phosphoinositide 3-kinase complex. 
  • Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer. 
  • Role of alpha 1 adrenoceptors in the turnover of phosphatidylinositol and of alpha 2 adrenoceptors in the regulation of cyclic AMP accumulation in hamster adipocytes. 
  • Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization. 
  • Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors. 
  • Role of ornithine decarboxylase in cardiac growth and hypertrophy. 
  • Role of polyamines in isoproterenol-induced cardiac hypertrophy: effects of alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase. 
  • Role of presynaptic input in the ontogeny of adrenergic cell signaling in rat brain: beta receptors, adenylate cyclase and c-fos protooncogene expression. 
  • Role of sympathetic neurons in development of beta-adrenergic control of ornithine decarboxylase activity in peripheral tissues: effects of neonatal 6-hydroxydopamine treatment. 
  • Roles of the AMP-activated and cyclic-AMP-dependent protein kinases in the adrenaline-induced inactivation of acetyl-CoA carboxylase in rat adipocytes. 
  • Secretion of surfactant by rat alveolar type II cells: morphometric analysis and three-dimensional reconstruction. 
  • Selective alteration in high affinity agonist binding: a mechanism of beta-adrenergic receptor desensitization. 
  • Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus. 
  • Selective linkage of beta-adrenergic receptors to functional responses in developing rat lung and liver: phosphatidic acid phosphatase, ornithine decarboxylase and lung liquid reabsorption. 
  • Selective loss of ornithine decarboxylase response to adrenergic agonists and glucagon during food deprivation of neonatal rats. 
  • Selective phosphorylation of PKA targets after β-adrenergic receptor stimulation impairs myofilament function in Mybpc3-targeted HCM mouse model. 
  • Sensitization of frog erythrocyte adenylate cyclase system by tumor-promoting phorbol diesters. 
  • Simulated microgravity produces attenuated baroreflex-mediated pressor, chronotropic, and inotropic responses in mice. 
  • Slowly reversible binding of catecholamine to a nucleotide-sensitive state of the beta-adrenergic receptor. 
  • Solubilization and characterization of the beta-adrenergic receptor binding sites of frog erythrocytes. 
  • Specific inhibition of protein kinase A in granulosa cells abolishes gonadotropin regulation of the proopiomelanocortin promoter. 
  • Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles. 
  • Stimulation of catecholamine-sensitive adenylate cyclase by 5'-guanylyl-imidodiphosphate. 
  • Stimulation of rat heart ornithine decarboxylase by isoproterenol evidence for post-translational control of enzyme activity? 
  • Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor. 
  • Subsensitivity of adenylate cyclase and decreased beta-adrenergic receptor binding after chronic exposure to (minus)-isoproterenol in vitro. 
  • Substitution of an extracellular cysteine in the beta 2-adrenergic receptor enhances agonist-promoted phosphorylation and receptor desensitization. 
  • Surfactant apoprotein in adult rat lung compartments is increased by dexamethasone. 
  • Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. 
  • Synergistic effect of dexamethasone and isoproterenol on the expression of angiotensinogen in immortalized rat proximal tubular cells. 
  • Systematic errors in detecting biased agonism: Analysis of current methods and development of a new model-free approach. 
  • Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice. 
  • Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts. 
  • Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins. 
  • Temperature immutability of adenyl cyclase-coupled beta adrenergic receptors. 
  • The beta-adrenergic receptor and adenylate cyclase. 
  • The beta-adrenergic receptor kinase: role in homologous desensitization in S49 lymphoma cells. 
  • The mammalian beta 2-adrenergic receptor: reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system. 
  • The molecular size of adenylate cyclase in the absence and presence of nucleotide and hormone effectors. 
  • The rat testicular A1 adenosine receptor-adenylate cyclase system. 
  • The regulation of proenkephalin expression in a distinct population of glial cells. 
  • The β-adrenoceptor agonist isoproterenol rescues acetaminophen-injured livers through increasing progenitor numbers by Wnt in mice. 
  • Thyroid hormone differentially regulates development of beta-adrenergic receptors, adenylate cyclase and ornithine decarboxylase in rat heart and kidney. 
  • Thyroid hormone regulates ontogeny of beta adrenergic receptors and adenylate cyclase in rat heart and kidney: effects of propylthiouracil-induced perinatal hypothyroidism. 
  • Thyroid hormone regulation of beta-adrenergic receptor number. 
  • Topographic separation of adenylate cyclase and hormone receptors in the plasma membrane of toad erythrocyte ghosts. 
  • Transgenic overexpression of the Ca2+-binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performance. 
  • Translocation and uncoupling of the beta-adrenergic receptor in rat lung after catecholamine promoted desensitization in vivo. 
  • Transmethylation reactions regulate affinity and functional activity of chemotactic factor receptors on macrophages. 
  • Two distinct pathways for cAMP-mediated down-regulation of the beta 2-adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level. 
  • Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury. 
  • Unique uncoupling of the frog erythrocyte adenylate cyclase system by manganese. Loss of hormone and guanine nucleotide-sensitive enzyme activities without loss of nucleotide-sensitive, high affinity agonist binding. 
  • Uptake, storage, and distribution of amines in bovine adrenal medullary vesicles. 
  • Use of cell fusion techniques to probe the mechanism of catecholamine-induced desensitization of adenylate cyclase in frog erythrocytes. 
  • Use of resampling techniques to estimate the variance of parameters in pharmacological assays when experimental protocols preclude independent replication: an example using Schild regressions. 
  • Very-long-chain acyl-coenzyme a dehydrogenase deficiency in mice. 
  • alpha-Adrenergic receptors in rat parotid cells. I. Correlation of [3H]dihydroergocryptine binding and catecholamine-stimulated potassium efflux. 
  • beta Adrenergic control of c-fos protooncogene expression in developing rat brain regions. 
  • beta(3)-adrenoceptor deficiency blocks nitric oxide-dependent inhibition of myocardial contractility. 
  • beta-Adrenergic action on wild-type and KPQ mutant human cardiac Na+ channels: shift in gating but no change in Ca2+:Na+ selectivity. 
  • beta-Adrenergic modulation of muscarinic cholinergic receptor expression and function in developing heart. 
  • beta-Adrenergic receptor regulation by agonists and membrane depolarization in rat brain slices. 
  • beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery