Isoquinolines

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  Subject Areas on Research

  • A randomized double blind study to evaluate efficacy of palonosetron with dexamethasone versus palonosetron alone for prevention of postoperative and postdischarge nausea and vomiting in subjects undergoing laparoscopic surgeries with high emetogenic risk. 
  • AAL881, a novel small molecule inhibitor of RAF and vascular endothelial growth factor receptor activities, blocks the growth of malignant glioma. 
  • Activation of messenger-independent protein kinases in wild-type and phorbol ester-resistant EL4 thymoma cells. 
  • Activation of protein kinase C inhibits human keratinocyte migration. 
  • Adherence to antiemetic guidelines in patients with malignant glioma: a quality improvement project to translate evidence into practice. 
  • Aluminum-induced DNA synthesis in osteoblasts: mediation by a G-protein coupled cation sensing mechanism. 
  • Amine-aldehyde metabolites and alcoholism: fact, myth or uncertainty. 
  • Analogs of tetrahydroisoquinoline natural products that inhibit cell migration and target galectin-3 outside of its carbohydrate-binding site. 
  • Antiemetics: American Society of Clinical Oncology clinical practice guideline update. 
  • Cardiopulmonary effects of the novel neuromuscular blocking drug GW280430A (AV430A) in dogs. 
  • Cofractionation of the 17-kD PK 14105 binding site protein with solubilized peripheral-type benzodiazepine binding sites. 
  • Cognitive deficits and CNS damage after a 4-day binge ethanol exposure in rats. 
  • Conformational Analysis and Molecular Modeling of 1-Phenyl-, 4-Phenyl-, and 1-Benzyl-1,2,3,4-tetrahydroiso-quinolines as D1 Dopamine Receptor Ligands 
  • Conformational changes at the carboxyl terminus of Galpha occur during G protein activation. 
  • Conformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine. 
  • Constituents from the root and stem of Aristolochia elegans. 
  • Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation. 
  • D2 Dopamine Receptor G Protein-Biased Partial Agonists Based on Cariprazine. 
  • Daclatasvir in combination with asunaprevir and beclabuvir for hepatitis C virus genotype 1 infection with compensated cirrhosis. 
  • Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor. 
  • Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation. 
  • Dye-coupling in three-dimensional histoculture of rat lingual frenulum. 
  • Endogenous protein kinase-C activation in osteoblast-like cells modulates responsiveness to estrogen and estrogen receptor levels. 
  • Fixed-dose combination therapy with daclatasvir, asunaprevir, and beclabuvir for noncirrhotic patients with HCV genotype 1 infection. 
  • Fluorescent probes as indicators of conformation changes in transducin on activation. 
  • Forskolin stimulation of water and cation permeability in aquaporin 1 water channels. 
  • G protein-coupled receptor kinase 2 activates radixin, regulating membrane protrusion and motility in epithelial cells. 
  • Gastrointestinal symptoms in cancer patients with advanced disease: new methodologies, insights, and a proposed approach. 
  • HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling. 
  • Identification, partial purification, and characterization of a novel phospholipid-dependent and fatty acid-activated protein kinase from human platelets. 
  • In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration. 
  • Induction of angiotensin converting enzyme in the neointima after vascular injury. Possible role in restenosis. 
  • Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic β-Cells. 
  • Inhibition of HIF prolyl-hydroxylase domain to correct anemia in patients with chronic kidney disease. 
  • Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis. 
  • Interleukin 10 is induced by recombinant HIV-1 Nef protein involving the calcium/calmodulin-dependent phosphodiesterase signal transduction pathway. 
  • Long-acting serotonin antagonist (Palonosetron) and the NK-1 receptor antagonists: does extended duration of action improve efficacy? 
  • Management of postdischarge nausea and vomiting after ambulatory surgery. 
  • Managing toxicities of phosphatidylinositol-3-kinase (PI3K) inhibitors. 
  • Maximal beta3-adrenergic regulation of lipolysis involves Src and epidermal growth factor receptor-dependent ERK1/2 activation. 
  • Mitochondrial benzodiazepine receptors regulate steroid biosynthesis. 
  • Modulation of RNA polymerase II elongation efficiency by C-terminal heptapeptide repeat domain kinase I. 
  • N-methylated 5-alkenyloxazolium salt transformations. 
  • Neuromuscular blocking activity and therapeutic potential of mixed-tetrahydroisoquinolinium halofumarates and halosuccinates in rhesus monkeys. 
  • Neuromuscular effects of rapacuronium in pediatric patients during nitrous oxide-halothane anesthesia: comparison with mivacurium. 
  • Nuclear receptor LXRalpha is involved in cAMP-mediated human renin gene expression. 
  • On the mechanism of acetylcholine receptor accumulation at newly formed synapses on chick myotubes. 
  • PIP5K1α inhibition as a therapeutic strategy for prostate cancer. 
  • Phase I Study of the Combination of Bendamustine, Rituximab, and Pixantrone in Patients With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma. 
  • Phase II study of amonafide in advanced pancreatic adenocarcinoma. 
  • Phase II study to evaluate the safety and efficacy of intravenous palonosetron (PAL) in primary malignant glioma (MG) patients receiving standard radiotherapy (RT) and concomitant temozolomide (TMZ). 
  • Phorbol ester inhibits granulocyte-macrophage colony-stimulating factor binding and tyrosine phosphorylation. 
  • Potential importance of tissue angiotensin-converting enzyme inhibition in preventing neointima formation. 
  • Preclinical pharmacology of GW280430A (AV430A) in the rhesus monkey and in the cat: a comparison with mivacurium. 
  • Progressive cardiac dysfunction and fibrosis in the cardiomyopathic hamster and effects of growth hormone and angiotensin-converting enzyme inhibition. 
  • Properties of secretin receptor internalization differ from those of the beta(2)-adrenergic receptor. 
  • Purification and characterization of a protein associated with peripheral-type benzodiazepine binding sites. 
  • Purification, cloning, and expression of a peripheral-type benzodiazepine receptor. 
  • Quinapril--a new angiotensin-converting enzyme inhibitor: an overview. 
  • Quinocarmycin analog DX-52-1 inhibits cell migration and targets radixin, disrupting interactions of radixin with actin and CD44. 
  • Reactivation of Epstein-Barr Virus by HIF-1α Requires p53. 
  • Regulation of cholecystokinin secretion by calcium-dependent calmodulin kinase II: differential effects of phenylalanine and cAMP. 
  • Site-Selective Copper-Catalyzed Amination and Azidation of Arenes and Heteroarenes via Deprotonative Zincation. 
  • Somatostatin immunohistochemistry of hippocampal slices with lucifer yellow-stained pyramidal neurons responding to somatostatin. 
  • Stimulation of aquaporin-mediated fluid transport by cyclic GMP in human retinal pigment epithelium in vitro. 
  • Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors. 
  • Synthesis and dopaminergic properties of benzo-fused analogues of quinpirole and quinelorane. 
  • Synthesis of ultra-short-acting neuromuscular blocker GW 0430: a remarkably stereo- and regioselective synthesis of mixed tetrahydroisoquinolinium chlorofumarates. 
  • Synthesis, fluorine-18 radiolabeling, and in vitro characterization of 1-iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivatives as potential PET radioligands for imaging peripheral benzodiazepine receptor. 
  • Synthetic isoquinoline in acute respiratory disease. 
  • Synthetic peptide corresponding to a conserved domain of the retroviral protein p15E blocks IL-1-mediated signal transduction. 
  • Tetrahydropapaveroline and salsolinol alter 45Ca2+ efflux within perfused hippocampus of unrestrained rats. 
  • The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. 
  • The combination of novel low molecular weight inhibitors of RAF (LBT613) and target of rapamycin (RAD001) decreases glioma proliferation and invasion. 
  • The effects of tenapanor on serum fibroblast growth factor 23 in patients receiving hemodialysis with hyperphosphatemia. 
  • The peripheral-type benzodiazepine receptor is functionally linked to Leydig cell steroidogenesis. 
  • Understanding the characteristics of nonspecific binding of drug-like compounds to canonical stem-loop RNAs and their implications for functional cellular assays. 
  • Upregulation of AKT1 protein expression in forskolin-stimulated macrophage: evidence from ChIP analysis that CREB binds to and activates the AKT1 promoter. 
  • Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. 
  • beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi. 
  • beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. 
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  Keywords of People

  • Cianciolo, George James, Associate Professor Emeritus of Pathology, Pathology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Nielsen, Karen Cristina, Associate Professor of Anesthesiology, Anesthesiology, Ambulatory