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Subject Areas on Research
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13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS).
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211At- and 131I-labeled bisphosphonates with high in vivo stability and bone accumulation.
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5-substituted derivatives of 6-halogeno-3-((2-(S)-azetidinyl)methoxy)pyridine and 6-halogeno-3-((2-(S)-pyrrolidinyl)methoxy)pyridine with low picomolar affinity for alpha4beta2 nicotinic acetylcholine receptor and wide range of lipophilicity: potential probes for imaging with positron emission tomography.
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A kit method for the high level synthesis of [211At]MABG.
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A method for the radiohalogenation of proteins resulting in decreased thyroid uptake of radioiodine.
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A procedure for the preferential radioiodination of small amounts of protein in the presence of excess lipids.
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A roadmap for interpreting (13)C metabolite labeling patterns from cells.
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A thermally responsive biopolymer for intra-articular drug delivery.
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An alternative and expedient synthesis of radioiodinated 4-iodophenylalanine.
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Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics.
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Antiepidermal growth factor variant III scFv fragment: effect of radioiodination method on tumor targeting and normal tissue clearance.
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Astatination of proteins using an N-succinimidyl tri-n-butylstannyl benzoate intermediate.
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Astatine-211 labeling of internalizing anti-EGFRvIII monoclonal antibody using N-succinimidyl 5-[211At]astato-3-pyridinecarboxylate.
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Autodegradation of 125I-labeled human epidermal cell surface proteins.
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Automated radiosynthesis of [11C]morphine for clinical investigation.
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Brush border enzyme-cleavable linkers: Evaluation for reducing renal uptake of radiolabeled prostate-specific membrane antigen inhibitors.
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Catabolism of radioiodinated murine monoclonal antibody F(ab')2 fragment labeled using N-succinimidyl 3-iodobenzoate and Iodogen methods.
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Characterization of symbiont populations in life-history stages of mussels from chemosynthetic environments.
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Characterization of the Saccharomyces cerevisiae ATP-Interactome using the iTRAQ-SPROX Technique.
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Chimeric anti-tenascin antibody 81C6: increased tumor localization compared with its murine parent.
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Clinical experience with alpha-particle emitting 211At: treatment of recurrent brain tumor patients with 211At-labeled chimeric antitenascin monoclonal antibody 81C6.
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Computerized liquid scintillation counting data management. 1. Time sequence for decay correction: a key for data storage and retrieval.
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Constrained selected reaction monitoring: quantification of selected post-translational modifications and protein isoforms.
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Current trends in differential expression proteomics: isotopically coded tags.
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Cytotoxicity of alpha-particle-emitting 5-[211At]astato-2'-deoxyuridine in human cancer cells.
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D-Amino acid peptide residualizing agents bearing N-hydroxysuccinimido- and maleimido-functional groups and their application for trastuzumab radioiodination.
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Detection of oncornavirus antigenic activity in human urothelial tissues.
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Determination of an angiotensin II-regulated proteome in primary human kidney cells by stable isotope labeling of amino acids in cell culture (SILAC).
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Development of Intrinsically Labeled Eggs and Poultry Meat for Use in Human Metabolic Research.
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Development of a radioimmunoassay for fetal antigen 2.
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Discovery of Manassantin A Protein Targets Using Large-Scale Protein Folding and Stability Measurements.
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Effect of radioiodination on the binding of monoclonal antibody DF3 to breast carcinoma cells.
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Enhanced binding and inertness to dehalogenation of alpha-melanotropic peptides labeled using N-succinimidyl 3-iodobenzoate.
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Evaluation of a simpler technique for in-vivo labelling of red blood cells with 99mTc.
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Evaluation of an internalizing monoclonal antibody labeled using N-succinimidyl 3-[131I]iodo-4-phosphonomethylbenzoate ([131I]SIPMB), a negatively charged substituent bearing acylation agent.
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Fluorine-18 labeling of monoclonal antibodies and fragments with preservation of immunoreactivity.
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Fluorine-18-labeled monoclonal antibody fragments: a potential approach for combining radioimmunoscintigraphy and positron emission tomography.
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Global analysis of protein folding thermodynamics for disease state characterization.
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High-level production of alpha-particle-emitting (211)At and preparation of (211)At-labeled antibodies for clinical use.
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Hyperthermia increases accumulation of technetium-99m-labeled liposomes in feline sarcomas.
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Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics.
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Identification of S-nitrosylated targets of thioredoxin using a quantitative proteomic approach.
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Identification of dengue RNA binding proteins using RNA chromatography and quantitative mass spectrometry.
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Improved synthesis of N-succinimidyl 4-[18F]fluorobenzoate and its application to the labeling of a monoclonal antibody fragment.
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Improved tumor targeting of anti-HER2 nanobody through N-succinimidyl 4-guanidinomethyl-3-iodobenzoate radiolabeling.
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Inhibition of dynamic protein palmitoylation in intact cells with tunicamycin.
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Inositol phosphate metabolomics: merging genetic perturbation with modernized radiolabeling methods.
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Labeling internalizing anti-epidermal growth factor receptor variant III monoclonal antibody with (177)Lu: in vitro comparison of acyclic and macrocyclic ligands.
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Labeling monoclonal antibodies with halogen nuclides.
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Labeling proteins using aryl iodide acylation agents: influence of meta vs para substitution on in vivo stability.
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Labeling proteins with fluorine-18 using N-succinimidyl 4-[18F]fluorobenzoate.
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Large-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins Using SILAC-SPROX.
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Matching isotopic distributions from metabolically labeled samples.
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Measurement of methotrexate polyglutamates in human erythrocytes by ion-pair UPLC-MS/MS.
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Measuring long-lived 13C2 state lifetimes at natural abundance.
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Method for radioiodination of proteins using N-succinimidyl 3-hydroxy-4-iodobenzoate.
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Molecular manipulation and analysis of inositol phosphate and pyrophosphate levels in Mammalian cells.
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Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry.
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N-Succinimidyl guanidinomethyl iodobenzoate protein radiohalogenation agents: influence of isomeric substitution on radiolabeling and target cell residualization.
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N-succinimidyl 3-[(131)I]iodo-4-phosphonomethylbenzoate ([(131)I]SIPMB), a negatively charged substituent-bearing acylation agent for the radioiodination of peptides and mAbs.
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N-succinimidyl 4-methyl-3-(tri-n-butylstannyl)benzoate: synthesis and potential utility for the radioiodination of monoclonal antibodies.
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No-carrier-added (4-fluoro-3-[131I]iodobenzyl)guanidine and (3-[211At]astato-4-fluorobenzyl)guanidine.
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No-carrier-added synthesis of a 4-methyl-substituted meta-iodobenzylguanidine analogue.
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No-carrier-added synthesis of meta-[131I]iodobenzylguanidine.
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Optical and radioiodinated tethered Hsp90 inhibitors reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells.
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Organ distribution of 99mTc-labelled aminethiols.
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Overview of protein phosphorylation.
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Photoaffinity cross-linking of a radioiodinated probe, 125I-A55453, into alpha 1-adrenergic receptors.
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Positively charged templates for labeling internalizing antibodies: comparison of N-succinimidyl 5-iodo-3-pyridinecarboxylate and the D-amino acid peptide KRYRR.
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Positron emission tomography for the evaluation of pancreatic disease.
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Preclinical Evaluation of 18F-Labeled Anti-HER2 Nanobody Conjugates for Imaging HER2 Receptor Expression by Immuno-PET.
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Preparation of 5-[131I]iodo- and 5-[211At]astato-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) uracil by a halodestannylation reaction.
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Preparation of N-succinimidyl 3-[*I]iodobenzoate: an agent for the indirect radioiodination of proteins.
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Preparation of a biologically stable and immunogenically competent astatinated protein.
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Proteome analysis by mass spectrometry.
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Proteome-Wide Characterization of Phosphorylation-Induced Conformational Changes in Breast Cancer.
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Proteome-Wide Structural Biology: An Emerging Field for the Structural Analysis of Proteins on the Proteomic Scale.
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Proteomic analysis of proteins related to rice grain chalkiness using iTRAQ and a novel comparison system based on a notched-belly mutant with white-belly.
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Proteomic characterization of the cellular response to nitrosative stress mediated by s-nitrosoglutathione reductase inhibition.
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Proteomic identification and functional characterization of MYH9, Hsc70, and DNAJA1 as novel substrates of HDAC6 deacetylase activity.
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Proteomic profiling of a layered tissue reveals unique glycolytic specializations of photoreceptor cells.
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Proteomics in prostate cancer.
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Radiohalogenation of a monoclonal antibody using an N-succinimidyl 3-(tri-n-butylstannyl)benzoate intermediate.
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Radioimmunotherapy of breast cancer xenografts with monoclonal antibody ICR12 against c-erbB2 p185: comparison of iodogen and N-succinimidyl 4-methyl-3-(tri-n-butylstannyl)benzoate radioiodination methods.
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Radioiodinated antibody targeting of the HER-2/neu oncoprotein: effects of labeling method on cellular processing and tissue distribution.
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Radioiodination and astatination of octreotide by conjugation labeling.
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Radioiodination of a monoclonal antibody using N-succinimidyl 5-iodo-3-pyridinecarboxylate.
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Radioiodination of antibodies via N-succinimidyl 2,4-dimethoxy-3-(trialkylstannyl)benzoates.
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Radioiodination of internalizing monoclonal antibodies using N-succinimidyl 5-iodo-3-pyridinecarboxylate.
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Radioiodination of proteins using N-succinimidyl 4-hydroxy-3-iodobenzoate.
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Radioiodination via D-amino acid peptide enhances cellular retention and tumor xenograft targeting of an internalizing anti-epidermal growth factor receptor variant III monoclonal antibody.
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Radiolabeled inhibitors as probes for imaging mutant IDH1 expression in gliomas: Synthesis and preliminary evaluation of labeled butyl-phenyl sulfonamide analogs.
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Radiolabeling and in vitro evaluation of (67)Ga-NOTA-modular nanotransporter--a potential Auger electron emitting EGFR-targeted radiotherapeutic.
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Radiolabelling of glucose-Tyr3-octreotate with 125I and analysis of its metabolism in rats: comparison with radiolabelled DOTA-Tyr3-octreotate.
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Radiopharmaceutical chemistry of targeted radiotherapeutics, Part 2: radiolytic effects of 211At alpha-particles influence N-succinimidyl 3-211AT-astatobenzoate synthesis.
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Radiopharmaceutical chemistry of targeted radiotherapeutics, part 4: Strategies for 211At labeling at high activities and radiation doses of 211At α-particles.
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Reagents for astatination of biomolecules: comparison of the in vivo distribution and stability of some radioiodinated/astatinated benzamidyl and nido-carboranyl compounds.
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Renal uptake of lutropin. Studies based on electron microscopic autoradiography and nephrectomy.
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Repressing a repressor: gibberellin-induced rapid reduction of the RGA protein in Arabidopsis.
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SIB-DOTA: a trifunctional prosthetic group potentially amenable for multi-modal labeling that enhances tumor uptake of internalizing monoclonal antibodies.
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SILAC-pulse proteolysis: A mass spectrometry-based method for discovery and cross-validation in proteome-wide studies of ligand binding.
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Site of Tc-99m binding to the red blood cell: concise communication.
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Stable isotope labeling strategy for protein-ligand binding analysis in multi-component protein mixtures.
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StableIsotope Labeling with Amino Acids in Cell Culture (SILAC)-based strategy for proteome-wide thermodynamic analysis of protein-ligand binding interactions.
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Static secondary-ion mass spectrometric investigation of the surface structure of organic plasma-deposited films prepared from stable-isotope-labeled precursors. 1. Carbonyl precursors.
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Synthesis and evaluation of 18F-labeled choline as an oncologic tracer for positron emission tomography: initial findings in prostate cancer.
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Synthesis and evaluation of 4-[18F]fluoropropoxy-3-iodobenzylguanidine ([18F]FPOIBG): A novel 18F-labeled analogue of MIBG.
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Synthesis of 11C-labeled chlorpromazine directly from [11C]carbon dioxide.
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Synthesis of iodine-125 labeled (+/-)-15-(4-azidobenzyl)carazolol: a potent beta-adrenergic photoaffinity probe.
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Synthesis of radioiodinated N-succinimidyl iodobenzoate: optimization for use in antibody labelling.
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Synthesis of the labeled D1 receptor antagonist SCH 23390 using [11C]carbon dioxide.
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Synthesis, purification, and in vitro stability of 211At- and 125I-labeled amidobisphosphonates.
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The doubly labeled water method produces highly reproducible longitudinal results in nutrition studies.
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The sources of rat biliary cholesterol and bile acid.
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Tracking the in vivo fate of recombinant polypeptides by isotopic labeling.
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Transfer of radioiodine from iodinated oncornavirus proteins to unlabeled protein carrier during routine procedures for peptide mapping.
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Treatment of HER2-positive breast carcinomatous meningitis with intrathecal administration of alpha-particle-emitting (211)At-labeled trastuzumab.
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Tumor blood flow measured by perfusion computed tomography and 15O-labeled water positron emission tomography: a comparison study.
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Tumor-specific anti-epidermal growth factor receptor variant III monoclonal antibodies: use of the tyramine-cellobiose radioiodination method enhances cellular retention and uptake in tumor xenografts.
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Understanding metabolism with flux analysis: From theory to application.
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Using dynamic programming to create isotopic distribution maps from mass spectra.
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Value and limitations of testicular scanning by in vivo labelling of RBC with 99mTc.
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Keywords of People
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Abbruzzese, James,
D. C. I. Distinguished Professor of Medical Oncology,
Medicine, Medical Oncology
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Chitneni, Satish K.,
Associate Professor in Radiology,
Radiology
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Farsiu, Sina,
Paul Ruffin Scarborough Distinguished Associate Professor of Engineering,
Electrical and Computer Engineering
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McLendon, Roger Edwin,
Professor of Pathology,
Pathology
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Sampson, John Howard,
Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine,
Immunology