Japan

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  Subject Areas on Research

  • A Cluster Analysis of the Japanese Multicenter Outpatient Registry of Patients With Atrial Fibrillation. 
  • A Comparative Study of Serum Phosphate and Related Parameters in Chronic Kidney Disease between the USA and Japan. 
  • A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome. 
  • A comparative study of monoclonal gammopathies and immunoglobulin levels in Japanese and United States elderly. 
  • A cost-effectiveness comparisons of adult spinal deformity surgery in the United States and Japan. 
  • A genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins. 
  • A nationwide survey of intravenous antimicrobial use in intensive care units in Japan. 
  • AOA-JOA Traveling Fellowship 2006: The Fellows' Travel Log. 
  • Adalimumab in Active and Inactive, Non-Infectious Uveitis: Global Results from the VISUAL I and VISUAL II Trials. 
  • Advancing Nurses' Role to Address Issues Facing Japanese Anesthesia Practice. 
  • Age and activity status affect muscle reoxygenation time after maximal cycling exercise. 
  • Ageing, status politics and sociological theory. 
  • An analysis of the reasons for Japan's low infant mortality rate. 
  • An international comparison of patients undergoing percutaneous coronary intervention: A collaborative study of the National Cardiovascular Data Registry (NCDR) and Japan Cardiovascular Database-Keio interhospital Cardiovascular Studies (JCD-KiCS). 
  • Angiotensin-converting enzyme gene and retinal arteriolar narrowing: the Funagata Study. 
  • Angle-closure glaucoma in Asians: comparison of biometric and anterior segment parameters between Japanese and Chinese subjects. 
  • Anhedonia in Japanese patients with Parkinson's disease: analysis using the Snaith-Hamilton Pleasure Scale. 
  • Apolipoprotein E in Creutzfeldt-Jakob disease. 
  • Assessment of the reductions in night-time blood pressure and dipping induced by antihypertensive medication using a home blood pressure monitor. 
  • Association between asleep blood pressure and brain natriuretic peptide during antihypertensive treatment: the Japan Morning Surge-Target Organ Protection (J-TOP) study. 
  • Association of Arterial Stiffness With Kidney Function Among Adults Without Chronic Kidney Disease. 
  • Association of Cardiovascular Outcomes With Masked Hypertension Defined by Home Blood Pressure Monitoring in a Japanese General Practice Population. 
  • Association of electrocardiographic left ventricular hypertrophy with incident cardiovascular disease in Japanese older hypertensive patients. 
  • Association of genetic variants on 8p21 and 4q12 with age-related macular degeneration in Asian populations. 
  • Association of high pulse pressure with proteinuria in subjects with diabetes, prediabetes, or normal glucose tolerance in a large Japanese general population sample. 
  • Association of high-sensitivity cardiac troponin T and N-terminal pro-brain-type natriuretic peptide with left ventricular structure: J-HOP study. 
  • Association of the human type C retrovirus with a subset of adult T-cell cancers. 
  • Blunted cyclic variation of heart rate predicts mortality risk in post-myocardial infarction, end-stage renal disease, and chronic heart failure patients. 
  • Body dimensions of Japanese and American gymnasts. 
  • Body mass index and vein occlusion. 
  • Bootstrapping word order in prelexical infants: a Japanese-Italian cross-linguistic study. 
  • Both chronic kidney disease and nocturnal blood pressure associate with strokes in the elderly. 
  • Brief assessment of cognition in schizophrenia: validation of the Japanese version. 
  • CMPK1 and RBP3 are associated with corneal curvature in Asian populations. 
  • Changes in plasma unit distributions to hospitals over a 10-year period. 
  • Circulating des-acyl ghrelin improves cardiovascular risk prediction in older hypertensive patients. 
  • Clinical Impact of Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve on Japanese Population in the ADVANCE Registry. 
  • Clinical Impact of External Laryngeal Manipulation During Laryngoscopy on Tracheal Intubation Success in Critically Ill Children. 
  • Clinical Quantification of Myocardial Blood Flow Using PET: Joint Position Paper of the SNMMI Cardiovascular Council and the ASNC. 
  • Clinical course and flow cytometric analysis of paroxysmal nocturnal hemoglobinuria in the United States and Japan. 
  • Clinical trials in Japan and the United States. 
  • Clustering and heritability of insulin resistance in Chinese and Japanese hypertensive families: a Stanford-Asian Pacific Program in Hypertension and Insulin Resistance sibling study. 
  • Cognitions and behavior in asymmetric social dilemmas: a comparison of two cultures. 
  • Cohort profile: patient characteristics and quality-of-life measurements for newly-referred patients with atrial fibrillation-Keio interhospital Cardiovascular Studies-atrial fibrillation (KiCS-AF). 
  • Comment on "Can Minimally Invasive Esophagectomy Replace Open Esophagectomy for Esophageal Cancer? Latest Analysis of 24,233 Esophagectomies From the Japanese National Clinical Database". 
  • Comparative epitope mapping of sera from United States (US) and Japanese patients with bullous pemphigoid (BP) to fusion proteins encoded by BPAG1. 
  • Comparing the effects of ipragliflozin versus metformin on visceral fat reduction and metabolic dysfunction in Japanese patients with type 2 diabetes treated with sitagliptin: A prospective, multicentre, open-label, blinded-endpoint, randomized controlled study (PRIME-V study). 
  • Comparison of exudative age-related macular degeneration subtypes in Japanese and French Patients: multicenter diagnosis with multimodal imaging. 
  • Comparison of the efficacy, toxicity, and pharmacokinetics of a uracil/tegafur (UFT) plus oral leucovorin (LV) regimen between Japanese and American patients with advanced colorectal cancer: joint United States and Japan study of UFT/LV. 
  • Concepts of human differences: a comparison of American, Japanese, and Chinese children and adolescents. 
  • Contribution of chemotherapy to improved prognosis in stage 4 gastric cancer: trend analysis of a regional population-based cancer registry in Japan. 
  • Cost-effectiveness of the oral adsorbent AST-120 versus placebo for chronic kidney disease. 
  • Cricoid Pressure During Induction for Tracheal Intubation in Critically Ill Children: A Report From National Emergency Airway Registry for Children. 
  • Cross-cultural variability of component processes in autobiographical remembering: Japan, Turkey, and the USA. 
  • Cross-linguistic studies of directionality in first language acquisition: the Japanese data--a response to O'Grady, Suzuki-Wei & Cho 1986. 
  • Cross-national comparison of sex differences in health and mortality in Denmark, Japan and the US. 
  • Day-by-Day Variability of Home Blood Pressure and Incident Cardiovascular Disease in Clinical Practice: The J-HOP Study (Japan Morning Surge-Home Blood Pressure). 
  • Dentatorubral-pallidoluysian atrophy and Haw River syndrome. 
  • Diagnostic delay is common among patients with hypophosphatasia: initial findings from a longitudinal, prospective, global registry. 
  • Differences in care-seeking behavior for acute chest pain in the United States and Japan. 
  • Discrimination of phonemic vowel length by Japanese infants. 
  • Effect of dosing time of angiotensin II receptor blockade titrated by self-measured blood pressure recordings on cardiorenal protection in hypertensives: the Japan Morning Surge-Target Organ Protection (J-TOP) study. 
  • Effectiveness of high rate and delayed detection ICD programming by race: A MADIT-RIT substudy. 
  • Effects and limitations of prosodic and semantic biases on syntactic disambiguation. 
  • Effects of low-dose atrial natriuretic peptide infusion on cardiac surgery-associated acute kidney injury: A multicenter randomized controlled trial. 
  • Efficacy and safety of brolucizumab versus aflibercept in eyes with polypoidal choroidal vasculopathy in Japanese participants of HAWK. 
  • Efficacy and safety of recombinant factor XIII on reducing blood transfusions in cardiac surgery: a randomized, placebo-controlled, multicenter clinical trial. 
  • Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial. 
  • Efficacy of eplerenone added to renin-angiotensin blockade in elderly hypertensive patients: the Jichi-Eplerenone Treatment (JET) study. 
  • Efficacy of interferon beta-1a plus remdesivir compared with remdesivir alone in hospitalised adults with COVID-19: a double-bind, randomised, placebo-controlled, phase 3 trial. 
  • Efficacy of linaclotide in irritable bowel syndrome with constipation: Real-world data. 
  • Emergence of Japanese infants' prosodic preferences in infant-directed vocabulary. 
  • Enzalutamide with androgen deprivation therapy in Japanese men with metastatic hormone-sensitive prostate cancer: A subgroup analysis of the phase III ARCHES study. 
  • Epstein-Barr Virus Antibody Titers Are Not Associated with Gastric Cancer Risk in East Asia. 
  • Ethnic Variations in Radiographic Parameters and SRS-22 Scores in Adult Spinal Deformity: A Comparison Between North American and Japanese Patients Above 50 Years of Age With Minimum 2-Year Follow-up. 
  • Even at 4 months, a labial is a good enough coronal, but not vice versa. 
  • Evening heart rate measured at home is associated with visceral obesity and abnormal fat distribution in patients with hypertension. 
  • Evolution and diversity in human herpes simplex virus genomes. 
  • Exposure to Atomic Bomb Radiation and Age-Related Macular Degeneration in Later Life: The Hiroshima-Nagasaki Atomic Bomb Survivor Study. 
  • External Validation for Acute Kidney Injury Severity Scores: A Multicenter Retrospective Study in 14 Japanese ICUs. 
  • Factors affecting prolonged length of stay in psychiatric patients in Japan: A retrospective observational study. 
  • Female aggression and male membership in troops of Japanese macaques and olive baboons. 
  • Fruit and vegetable consumption, Helicobacter pylori antibodies, and gastric cancer risk: A pooled analysis of prospective studies in China, Japan, and Korea. 
  • Further scrutiny of scientific whaling. 
  • Genome-wide analysis identifies novel susceptibility loci for myocardial infarction. 
  • Genome-wide association studies reveal genetic variants in CTNND2 for high myopia in Singapore Chinese. 
  • Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4. 
  • Genomewide search for type 2 diabetes susceptibility genes in four American populations. 
  • Global cardiovascular device innovation: Japan-USA synergies: Harmonization by Doing (HBD) program, a consortium of regulatory agencies, medical device industry, and academic institutions. 
  • Glycohemoglobin not as predictive as fasting glucose as a measure of prediabetes in predicting proteinuria. 
  • Hemoglobin Rahere, a human hemoglobin variant with amino acid substitution at the 2,3-diphosphoglycerate binding site. Functional consequences of the alteration and effects of bezafibrate on the oxygen bindings. 
  • Hospital mortality of patients aged 80 and older after surgical repair for type A acute aortic dissection in Japan. 
  • Impaired glucose tolerance, but not impaired fasting glucose, is associated with retinopathy in Japanese population: the Funagata study. 
  • Industry perspectives on ICH guidelines. 
  • Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation. 
  • It takes two to mimic: behavioral consequences of self-construals. 
  • Japan-USA Orbital Atherectomy for Calcific Coronary Lesions: COAST Study, Harmonization by Doing Proof-of-Concept. 
  • Japan-United States of America Harmonized Assessment by Randomized Multicentre Study of OrbusNEich's Combo StEnt (Japan-USA HARMONEE) study: primary results of the pivotal registration study of combined endothelial progenitor cell capture and drug-eluting stent in patients with ischaemic coronary disease and non-ST-elevation acute coronary syndrome. 
  • Kidney Outcomes Associated With SGLT2 Inhibitors Versus Other Glucose-Lowering Drugs in Real-world Clinical Practice: The Japan Chronic Kidney Disease Database. 
  • Lack of association of very low density lipoprotein receptor gene polymorphism with Caucasian Alzheimer's disease. 
  • Language-general biases and language-specific experience contribute to phonological detail in toddlers' word representations. 
  • Late Effects of Exposure to Ionizing Radiation and Age on Human Thymus Morphology and Function. 
  • Links between family relationships and best friendships in the United States and Japan. 
  • Living arrangement and coronary heart disease: the JPHC study. 
  • Long-Term Blood Pressure Variability, New-Onset Diabetes Mellitus, and New-Onset Chronic Kidney Disease in the Japanese General Population. 
  • Long-Term Survival in Patients With Acute Kidney Injury After Acute Type A Aortic Dissection Repair. 
  • Longevity-Associated FOXO3 Genotype and its Impact on Coronary Artery Disease Mortality in Japanese, Whites, and Blacks: A Prospective Study of Three American Populations. 
  • Lower Satisfaction After Adult Spinal Deformity Surgery in Japan Than in the United States Despite Similar SRS-22 Pain and Function Scores: A Propensity-Score Matched Analysis. 
  • MMP20 and ARMS2/HTRA1 Are Associated with Neovascular Lesion Size in Age-Related Macular Degeneration. 
  • Microsurgery: past, present, and future. 
  • Modeling daily flowering probabilities: expected impact of climate change on Japanese cherry phenology. 
  • Morning and Evening Home Blood Pressure and Risks of Incident Stroke and Coronary Artery Disease in the Japanese General Practice Population: The Japan Morning Surge-Home Blood Pressure Study. 
  • Morning blood pressure surge, morning platelet aggregation, and silent cerebral infarction in older Japanese hypertensive patients. 
  • Mortality patterns in developed countries. 
  • Mortality reduction in relation to implantable cardioverter defibrillator programming in the Multicenter Automatic Defibrillator Implantation Trial-Reduce Inappropriate Therapy (MADIT-RIT). 
  • Mothers speak less clearly to infants than to adults: a comprehensive test of the hyperarticulation hypothesis. 
  • Multicenter automatic defibrillator implantation trial: reduce inappropriate therapy (MADIT-RIT): background, rationale, and clinical protocol. 
  • Muscle contraction-induced limb blood flow variability during dynamic knee extensor. 
  • Mutational analysis of ATP7B and genotype-phenotype correlation in Japanese with Wilson's disease. 
  • Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial. 
  • New criteria for sepsis-induced coagulopathy (SIC) following the revised sepsis definition: a retrospective analysis of a nationwide survey. 
  • New-onset hypertension and risk for chronic kidney disease in the Japanese general population. 
  • Nighttime Blood Pressure Measured by Home Blood Pressure Monitoring as an Independent Predictor of Cardiovascular Events in General Practice. 
  • Nighttime Blood Pressure Phenotype and Cardiovascular Prognosis: Practitioner-Based Nationwide JAMP Study. 
  • Novel ICD Programming and Inappropriate ICD Therapy in CRT-D Versus ICD Patients: A MADIT-RIT Sub-Study. 
  • Ocular findings in Japanese patients with hydroxychloroquine retinopathy developing within 3 years of treatment. 
  • On-Treatment Blood Pressure and Cardiovascular Outcomes in Older Adults With Isolated Systolic Hypertension. 
  • Outcomes in two Japanese adenosine deaminase-deficiency patients treated by stem cell gene therapy with no cytoreductive conditioning. 
  • Pathology and imaging of hepatocellular neoplasms: are findings from Asian populations applicable to non-Asian groups? 
  • Phonological theory informs the analysis of intonational exaggeration in Japanese infant-directed speech. 
  • Phylogenetic diversity of 200+ isolates of the ectomycorrhizal fungus Cenococcum geophilum associated with Populus trichocarpa soils in the Pacific Northwest, USA and comparison to globally distributed representatives. 
  • Phylogeny and biogeography of East Asian evergreen oaks (Quercus section Cyclobalanopsis; Fagaceae): Insights into the Cenozoic history of evergreen broad-leaved forests in subtropical Asia. 
  • Physician attire in the intensive care unit in Japan influences visitors' perception of care. 
  • Planning and response to radiation exposures. 
  • Post-exercise hyperemia after ischemic and non-ischemic isometric handgrip exercise. 
  • Potentially functional variants in the core nucleotide excision repair genes predict survival in Japanese gastric cancer patients. 
  • Practice Patterns and Outcomes of Transcatheter Aortic Valve Replacement in the United States and Japan: A Report From Joint Data Harmonization Initiative of STS/ACC TVT and J-TVT. 
  • Predictive processing of novel compounds: evidence from Japanese. 
  • Predictors of Hospital Readmission and Surgical Site Infection in the United States, Denmark, and Japan: Is Risk Stratification a Universal Language? 
  • Prevalence and associations of epiretinal membranes in an adult Japanese population: the Funagata study. 
  • Prevalence and risk factors for age-related macular degeneration in an adult Japanese population: the Funagata study. 
  • Processing down the garden path in Japanese: processing of sentences with lexical homonyms. 
  • Prognostic value of estimated plasma volume in acute heart failure in three cohort studies. 
  • Prosodic planning while reading aloud: on-line examination of Japanese sentences. 
  • Racial impact of diurnal variations in blood pressure on cardiovascular events in chronic kidney disease. 
  • Re: Evidence for an "epidemic" of myopia. 
  • Recent changes in the U.S. age at death distribution: further observations. 
  • Reduction in Inappropriate ICD Therapy in MADIT-RIT Patients Without History of Atrial Tachyarrhythmia. 
  • Regional differences in gallbladder cancer pathogenesis: Insights from a multi-institutional comparison of tumor mutations. 
  • Regional differences in hypertensive cardiovascular remodeling between fishing and farming communities in Japan. 
  • Relation of the Metabolic Syndrome to Incident Colorectal Cancer in Young Adults Aged 20 to 49 Years. 
  • Replicating and extending the effects of auditory religious cues on dishonest behavior. 
  • Response to 'Supra-linear dose-response in the A-bomb study'. 
  • Retinal arteriolar narrowing predicts 5-year risk of hypertension in Japanese people: the Funagata study. 
  • Risk Profile and 1-Year Outcome of Newly Diagnosed Atrial Fibrillation in Japan　- Insights From GARFIELD-AF. 
  • Risk factors and mortality in invasive Rasamsonia spp. infection: Analysis of cases in the FungiScope® registry and from the literature. 
  • Risk factors for early unplanned readmission in patients with bipolar disorder: A retrospective observational study. 
  • SMBE proposal to the government of Japan. 
  • Segmental distributions and consonant-vowel association patterns in Japanese infant- and adult-directed speech. 
  • Seroprevalence of HTLV-I in Cheju Island, a Korean island adjacent to the endemic area of Japan. 
  • Should reperfusion strategies in myocardial infarction be modified for the very elderly? 
  • Smoking, Helicobacter Pylori Serology, and Gastric Cancer Risk in Prospective Studies from China, Japan, and Korea. 
  • Social motivation affecting individuals' actions in Japan during World War II: historical review. 
  • Speculation on the naming of Moyamoya disease. 
  • Speech rate development in Japanese-speaking children and proficiency in mora-timed rhythm. 
  • Statement regarding the pre and post market assessment of durable, implantable ventricular assist devices in the United States. 
  • Study protocol for a randomised controlled trial of cognitive processing therapy for post-traumatic stress disorder among Japanese patients: the Safety, Power, Intimacy, Esteem, Trust (SPINET) study. 
  • Survival after the age of 80 in the United States, Sweden, France, England, and Japan. 
  • Synergistic effect of chronic kidney disease and high circulatory norepinephrine level on stroke risk in Japanese hypertensive patients. 
  • Taming the wilderness: the lifestyle improvement movement in rural Japan, 1925-1965. 
  • Temporal changes in FFRCT-Guided Management of Coronary Artery Disease - Lessons from the ADVANCE Registry. 
  • Temporal trends in clinical characteristics and in-hospital mortality among patients with COVID-19 in Japan for waves 1, 2, and 3: A retrospective cohort study. 
  • The Population-Attributable Fraction for Premature Mortality Due to Cardiovascular Disease Associated With Stage 1 and 2 Hypertension Among Japanese. 
  • The U-shaped association between body mass index and gastric cancer risk in the Helicobacter pylori Biomarker Cohort Consortium: A nested case-control study from eight East Asian cohort studies. 
  • The clinical evaluation of the Endeavor zotarolimus-eluting coronary stent in Japanese patients with de novo native coronary artery lesions: primary results and 3-year follow-up of the Endeavor Japan study. 
  • The clinical evaluation of the new indirect calorimeter developed by the ICALIC project. 
  • The development of a phonological illusion: a cross-linguistic study with Japanese and French infants. 
  • The development of perceptual grouping biases in infancy: a Japanese-English cross-linguistic study. 
  • The impact of cigarette smoking on 24-hour blood pressure, inflammatory and hemostatic activity, and cardiovascular risk in Japanese hypertensive patients. 
  • The impact of the international guideline entitled Statistical Principles for Clinical Trials (ICH E9). 
  • The metabolic syndrome and retinal microvascular signs in a Japanese population: the Funagata study. 
  • The multidimensional nature of hyperspeech: evidence from Japanese vowel devoicing. 
  • The next generation: the need to expand upon traditional risk factors for stroke. 
  • Ticlopidine-associated ADAMTS13 activity deficient thrombotic thrombocytopenic purpura in 22 persons in Japan: a report from the Southern Network on Adverse Reactions (SONAR). 
  • Tolerability and efficacy of durvalumab in Japanese patients with advanced solid tumors. 
  • Universal definition and classification of heart failure: a report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure: Endorsed by the Canadian Heart Failure Society, Heart Failure Association of India, Cardiac Society of Australia and New Zealand, and Chinese Heart Failure Association. 
  • Urinary Angiotensinogen Could Be a Prognostic Marker of Renoprotective Effects of Alogliptin in Patients with Type 2 Diabetes. 
  • Utility of the Penn classification in predicting outcomes of surgery for acute type a aortic dissection. 
  • Validity of low-intensity continuous renal replacement therapy*. 
  • Venous thromboembolism, interleukin-6 and survival outcomes in patients with advanced ovarian clear cell carcinoma. 
  • Volume effect in paediatric brain tumour resection surgery: analysis of data from the Japanese national inpatient database. 
  • Whole-exome sequencing implicates UBE3D in age-related macular degeneration in East Asian populations. 
  • Widowhood and illness: a comparison of social network characteristics in France, Germany, Japan, and the United States. 
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  Keywords of People

  • Alexander, John Hunter Peel, Professor of Medicine, Medicine, Cardiology
  • Jiang, Linshan, Postdoctoral Associate, Asian & Middle Eastern Studies