Joints

• 

  Subject Areas on Research

  • A comparative analysis of bone and cartilage metabolism in two strains of guinea-pig with varying degrees of naturally occurring osteoarthritis. 
  • A thermally responsive biopolymer for intra-articular drug delivery. 
  • A three-dimensional biomechanical analysis of sumo and conventional style deadlifts. 
  • Abnormal joint and bone wound healing in hemophilia mice is improved by extending factor IX activity after hemarthrosis. 
  • Absence of posttraumatic arthritis following intraarticular fracture in the MRL/MpJ mouse. 
  • Anakinra as first-line disease-modifying therapy in systemic juvenile idiopathic arthritis: report of forty-six patients from an international multicenter series. 
  • Applied biomechanics in articular injuries: perspectives in the basic investigation of articular injuries and clinical application. 
  • Articular fractures. 
  • Articular fractures: does an anatomic reduction really change the result? 
  • Brief clinical report and review: the Marden-Walker syndrome. 
  • CAMPATH-1H in rheumatoid arthritis--an intravenous dose-ranging study. 
  • Caribbean and La Réunion Chikungunya Virus Isolates Differ in Their Capacity To Induce Proinflammatory Th1 and NK Cell Responses and Acute Joint Pathology. 
  • Clinical benefits of intra-articular anakinra for arthrofibrosis. 
  • Cyclooxygenase-2 inhibitors and nonsteroidal anti-inflammatory drugs in the management of arthritis. 
  • DEK in the synovium of patients with juvenile idiopathic arthritis: characterization of DEK antibodies and posttranslational modification of the DEK autoantigen. 
  • Decreased expression of nicotinamide phosphoribosyltransferase in patients with juvenile idiopathic arthritis receiving methotrexate. 
  • Echo-volume imaging. 
  • Enhanced Th17-cell responses render CCR2-deficient mice more susceptible for autoimmune arthritis. 
  • Enrichment of malondialdehyde-acetaldehyde antibody in the rheumatoid arthritis joint. 
  • Enthesitis-related arthritis is associated with higher pain intensity and poorer health status in comparison with other categories of juvenile idiopathic arthritis: the Childhood Arthritis and Rheumatology Research Alliance Registry. 
  • Evaluation of indium-111 chloride as a radiopharmaceutical for joint imaging in a rabbit model of arthritis. 
  • Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis. 
  • Fine-needle aspiration cytology of articular and periarticular lesions. 
  • From articular fracture to posttraumatic arthritis: a black box that needs to be opened. 
  • Gait and behavior in an IL1β-mediated model of rat knee arthritis and effects of an IL1 antagonist. 
  • Genetics of physiological dysregulation: findings from the long life family study using joint models. 
  • Health status of patients with juvenile rheumatoid arthritis at 1 and 5 years after diagnosis. 
  • IFNgamma primes macrophages for inflammatory activation by high molecular weight hyaluronan. 
  • Identification of an urinary metabolite profile associated with osteoarthritis. 
  • Imatinib mesylate for the treatment of steroid-refractory sclerotic-type cutaneous chronic graft-versus-host disease. 
  • Immune cell profiling in the joint following human and murine articular fracture. 
  • Immunofluorescence-guided atomic force microscopy to measure the micromechanical properties of the pericellular matrix of porcine articular cartilage. 
  • Impact of osteoarthritis on sports careers. 
  • Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group. 
  • Inhibition of spinal p38 MAPK prevents articular neutrophil infiltration in experimental arthritis via sympathetic activation. 
  • Interleukin-2 receptor levels in sera of patients with rheumatoid arthritis treated with sulfasalazine, parenteral gold, or placebo. 
  • Jaw-muscle architecture and mandibular morphology influence relative maximum jaw gapes in the sexually dimorphic Macaca fascicularis. 
  • Joint angular excursions during cyclical behaviors differ between tetrapod feeding and locomotor systems. 
  • Lack of association between juvenile idiopathic arthritis and fas gene polymorphism. 
  • Linkage mechanics and power amplification of the mantis shrimp's strike. 
  • Live fate-mapping of joint-associated fibroblasts visualizes expansion of cell contributions during zebrafish fin regeneration. 
  • Loss of cartilage structure, stiffness, and frictional properties in mice lacking PRG4. 
  • Metacarpophalangeal and interphalangeal joint reconstruction: use of silicone rubber-dacron prostheses for replacement of irreparable joints of the hand. 
  • Ontogenetic scaling of fore limb and hind limb joint posture and limb bone cross-sectional geometry in vervets and baboons. 
  • Open label study to assess infliximab safety and timing of onset of clinical benefit among patients with rheumatoid arthritis. 
  • PAD4 is not essential for disease in the K/BxN murine autoantibody-mediated model of arthritis. 
  • Particulate versus integrated evolution of the upper body in late pleistocene humans: a test of two models. 
  • Platelet-derived growth factor receptor-β (PDGFRβ) lineage tracing highlights perivascular cell to myofibroblast transdifferentiation during post-traumatic osteoarthritis. 
  • Post-traumatic osteoarthritis: improved understanding and opportunities for early intervention. 
  • Posttraumatic osteoarthritis. 
  • Proposal for levels of evidence schema for validation of a soluble biomarker reflecting damage endpoints in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis, and recommendations for study design. 
  • RBP-Jκ-dependent Notch signaling is required for murine articular cartilage and joint maintenance. 
  • Radiographic joint damage in rheumatoid arthritis: a community-based perspective. 
  • Reappraisal of OMERACT 8 draft validation criteria for a soluble biomarker reflecting structural damage endpoints in rheumatoid arthritis, psoriatic arthritis, and spondyloarthritis: the OMERACT 9 v2 criteria. 
  • Regulation of matrix turnover in meniscal explants: role of mechanical stress, interleukin-1, and nitric oxide. 
  • Reply to "Does progranulin account for the opposite effects of etanercept and infliximab/adalimumab in osteoarthritis?" by Wei et al. 
  • Response to Letter to the Editor on "The Role of Malnutrition in Ninety-Day Outcomes After Total Joint Arthroplasty". 
  • Role of Piezo Channels in Joint Health and Injury. 
  • Sustained efficacy of certolizumab pegol added to methotrexate in the treatment of rheumatoid arthritis: 2-year results from the RAPID 1 trial. 
  • Sustained improvement over two years in physical function, structural damage, and signs and symptoms among patients with rheumatoid arthritis treated with infliximab and methotrexate. 
  • TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways. 
  • TRPV4 as a therapeutic target for joint diseases. 
  • Targets to tackle--the pathophysiology of the disease. 
  • Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis. 
  • Testing of the OMERACT 8 draft validation criteria for a soluble biomarker reflecting structural damage in rheumatoid arthritis: a systematic literature search on 5 candidate biomarkers. 
  • The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the guinea pig. 
  • The development of posttraumatic arthritis after articular fracture. 
  • The role of microparticles in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus. 
  • The symptoms of osteoarthritis and the genesis of pain. 
  • The timing and influence of MRI on the management of patients with cervical facet dislocations remains highly variable: a survey of members of the Spine Trauma Study Group. 
  • Therapeutic opportunities to prevent post-traumatic arthritis: Lessons from the natural history of arthritis after articular fracture. 
  • Trabecular bone in the bird knee responds with high sensitivity to changes in load orientation. 
  • Unipedal balance is affected by lower extremity joint arthroplasty procedure 1 year following surgery. 
  • Urea as a passive transport marker for arthritis biomarker studies. 
  • Viability and apoptosis of human chondrocytes in osteochondral fragments following joint trauma. 
• 

  Keywords of People

  • Hilton, Matthew James, Associate Professor in Orthopaedic Surgery, Cell Biology
  • Olson, Steven Arthur, Goldner Jones Distinguished Professor of Orthopaedic Surgery, Orthopaedic Surgery