Karyotyping

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  Subject Areas on Research

  • 9p- in a girl with acute lymphocytic leukemia and sickle cell disease. 
  • A case of infantile acute lymphoblastic leukemia presenting with rearrangement of MLL at 11q23 and apparent insertion or translocation at 10p12. 
  • A genetic linkage map of Cryptococcus neoformans variety neoformans serotype D (Filobasidiella neoformans). 
  • A glial fibrillary acidic protein-expressing and tumorigenic cell line derived from an avian sarcoma virus-induced rat astrocytoma. 
  • A marker chromosome abnormality. Occurrence in chloramphenicol-associated acute leukemia. 
  • A model for human medulloblastoma. Growth, morphology, and chromosomal analysis in vitro and in athymic mice. 
  • A novel chromosomal rearrangement associated with therapy-related acute leukemia. 
  • A novel human cancer culture model for the study of prostate cancer. 
  • A novel neoplastic primary tumor-derived human prostate epithelial cell line. 
  • A patient with duplication (7)(p22.1pter) characterized by array-CGH. 
  • A serially transplantable human giant cell glioblastoma that maintains a near-haploid stem line. 
  • A subtle t(3;8) results in plausible juxtaposition of MYC and BCL6 in a child with Burkitt lymphoma/leukemia and ataxia-telangiectasia. 
  • A syndrome of autosomal dominant alternating hemiplegia: clinical presentation mimicking intractable epilepsy; chromosomal studies; and physiologic investigations. 
  • A unique form of mental retardation with a distinctive phenotype maps to Xq26-q27. 
  • ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background. 
  • Abdominal pain and a pelvic mass. 
  • Aberrant behaviors of young boys with fragile X syndrome. 
  • Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study. 
  • Acquired genomic copy number aberrations and survival in adult acute myelogenous leukemia. 
  • Acquisition and processing of a conditional dicentric chromosome in Saccharomyces cerevisiae. 
  • Adult-derived stem cells and their potential for use in tissue repair and molecular medicine. 
  • Allogeneic marrow transplantation for myelodysplastic syndrome with advanced disease morphology: a phase II study of busulfan, cyclophosphamide, and total-body irradiation and analysis of prognostic factors. 
  • Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts. 
  • Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts. 
  • Amplified C lambda and c-abl genes are on the same marker chromosome in K562 leukemia cells. 
  • Androgen and androgen receptor antagonist responsive primary African-American benign prostate epithelial cell line. 
  • Application of FISH to complex chromosomal rearrangements associated with chronic myelogenous leukemia. 
  • Asexual reproduction in a close relative of Arabidopsis: a genetic investigation of apomixis in Boechera (Brassicaceae). 
  • Assignment of the human glycogen debrancher gene to chromosome 1p21. 
  • Atypical chronic myeloid leukemia is clinically distinct from unclassifiable myelodysplastic/myeloproliferative neoplasms. 
  • BAALC expression predicts clinical outcome of de novo acute myeloid leukemia patients with normal cytogenetics: a Cancer and Leukemia Group B Study. 
  • Bone marrow and thymus transplantation in ataxia-telangiectasia. 
  • CD7+, CD4-, CD8- acute leukemia: a syndrome of malignant pluripotent lymphohematopoietic cells. 
  • Cadmium-induced neoplastic transformation of human prostate epithelial cells. 
  • Characterization of a human prostate adenocarcinoma cell line (DU 145) as a monolayer culture and as a solid tumor in athymic mice. 
  • Characterization of chromosome 17 abnormalities in medulloblastomas. 
  • Characterization of de novo duplications in eight patients by using fluorescence in situ hybridization with chromosome-specific DNA libraries. 
  • Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts. 
  • Chromosomal characteristics of childhood brain tumors. 
  • Chromosomal composition of four permanent cultured cell lines derived from human gliomas. 
  • Chromosomal composition of malignant human gliomas through serial subcutaneous transplantation in athymic mice. 
  • Chromosomal evolution in malignant human gliomas starts with specific and usually numerical deviations. 
  • Chromosomal localization of human glutamate receptor genes. 
  • Chromosomal progression of malignant human gliomas from biopsy to establishment as permanent lines in vitro. 
  • Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript. 
  • Chronic myelogenous leukemia. 
  • Clastogenicity of lead chromate particles in hamster and human cells. 
  • Clinical course and origin of epithelium in cases of epithelial downgrowth after Descemet stripping automated endothelial keratoplasty. 
  • Clinical experience with array CGH: case presentations from nine months of practice. 
  • Clinical implications of aneuploid cytogenetic profiles in adult acute leukemia. 
  • Clinicopathologic and cytogenic features of CD34 (My 10)-positive acute nonlymphocytic leukemia. 
  • Clinicopathologic and genetic spectrum of infantile B-lymphoblastic leukemia: a multi-institutional study. 
  • Clonal evolution in t(14;18)-positive follicular lymphoma, evidence for multiple common pathways, and frequent parallel clonal evolution. 
  • Clonal persistence and evolution during a decade of recurrent melanoma. 
  • Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase. 
  • Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. 
  • Combined immunodeficiency due to the selective absence of CD4 inducer T lymphocytes. 
  • Comparative genetic mapping in Boechera stricta, a close relative of Arabidopsis. 
  • Comparative genetic patterns of glioblastoma multiforme: potential diagnostic tool for tumor classification. 
  • Comparison of fluorescence in situ hybridization, cytogenetic analysis, and DNA index analysis to detect chromosomes 4 and 10 aneuploidy in pediatric acute lymphoblastic leukemia: a Pediatric Oncology Group study. 
  • Comprehensive molecular cytogenetic investigation of chromosomal abnormalities in human medulloblastoma cell lines and xenograft. 
  • Conditional dicentric chromosomes in yeast. 
  • Congenital central hypoventilation syndrome: mutation analysis of the receptor tyrosine kinase RET. 
  • Congenital ocular defects associated with an abnormality of the human chromosome 1: trisomy 1q32-qter. 
  • Constellation of congenital abnormalities in an infant: a new syndrome or tissue-specific mosaicism for trisomy 18? 
  • Context-dependent effects of whole-genome duplication during mammary tumor recurrence. 
  • Continuous human glioma-derived cell lines UC-11MG and UC-302MG. Morphologic, immunocytochemical and chromosomal characterization. 
  • Conversion of a stem cell leukemia from a T-lymphoid to a myeloid phenotype induced by the adenosine deaminase inhibitor 2'-deoxycoformycin. 
  • Correlation between selected environmental exposures and karyotype in acute myelocytic leukemia. 
  • Cryopreservation of neurospheres derived from human glioblastoma multiforme. 
  • Cytogenetic and molecular analysis of an unusual case of acute promyelocytic leukemia with a t(15;17;17)(q22;q23;q21). 
  • Cytogenetic and molecular analysis of inv dup(15) chromosomes observed in two patients with autistic disorder and mental retardation. 
  • Cytogenetic and molecular correlates between rodent and human renal cell carcinoma. 
  • Cytogenetic heterogeneity negatively impacts outcomes in patients with acute myeloid leukemia. 
  • Cytogenetics and mechanisms of spontaneous abortions: increased apoptosis and decreased cell proliferation in chromosomally abnormal villi. 
  • Cytogenetics of human brain tumors. 
  • DNA content and chromosomes in permanent cultured cell lines derived from malignant human gliomas. 
  • Demonstration of complex antigenic heterogeneity in a human glioma cell line and eight derived clones by specific monoclonal antibodies. 
  • Development and characterization of a genetic linkage map of Cryptococcus neoformans var. neoformans using amplified fragment length polymorphisms and other markers. 
  • Diploid apomicts of the Boechera holboellii complex display large-scale chromosome substitutions and aberrant chromosomes. 
  • Donor cell-derived leukemias/myelodysplastic neoplasms in allogeneic hematopoietic stem cell transplant recipients: a clinicopathologic study of 10 cases and a comprehensive review of the literature. 
  • Dysgenesis of testicular and streak gonads in the syndrome of mixed gonadal dysgenesis: perspective derived from a clinicopathologic analysis of twenty-one cases. 
  • Dysmorphologic features of the fetal pelvis in Down syndrome: prenatal sonographic depiction and diagnostic implications of the iliac angle. 
  • Escalation of daunorubicin and addition of etoposide in the ADE regimen in acute myeloid leukemia patients aged 60 years and older: Cancer and Leukemia Group B Study 9720. 
  • Establishment and characterization of a new human prostatic carcinoma cell line (DuPro-1). 
  • Establishment and characterization of the human medulloblastoma cell line and transplantable xenograft D283 Med. 
  • Establishment of the DU.528 human lymphohemopoietic stem cell line. 
  • Evidence for involvement of GNB1L in autism. 
  • Evidence for phenotypic plasticity in aggressive triple-negative breast cancer: human biology is recapitulated by a novel model system. 
  • Expression of mutated epidermal growth factor receptor by non-small cell lung carcinomas. 
  • Extramedullary leukemia adversely affects hematologic complete remission rate and overall survival in patients with t(8;21)(q22;q22): results from Cancer and Leukemia Group B 8461. 
  • Familial inheritance of a DXS164 deletion mutation from a heterozygous female. 
  • Fetal choroid plexus lesions. Relationship of antenatal sonographic appearance to clinical outcome. 
  • Fluorescence in situ hybridization analysis of keratinocyte growth factor gene amplification and dispersion in evolution of great apes and humans. 
  • Fragile X phenotype in a patient with a large de novo deletion in Xq27-q28. 
  • From embryo to teratocarcinoma in tissue culture. 
  • Genetic heterogeneity of gingival fibromatosis on chromosome 2p. 
  • Genomic instability and endoreduplication triggered by RAD17 deletion. 
  • Germline genetic variation in ETV6 and risk of childhood acute lymphoblastic leukaemia: a systematic genetic study. 
  • Gestational trophoblastic disease with coexistent normal fetus: evaluation by ultrasound-guided chorionic villus sampling. 
  • Hereditary renal cell carcinoma in the rat associated with nonrandom loss of chromosomes 5 and 6. 
  • High-grade B cell lymphoma, unclassifiable, with blastoid features: an unusual morphological subgroup associated frequently with BCL2 and/or MYC gene rearrangements and a poor prognosis. 
  • Human brain tumor xenografts. 
  • Hydroxyurea synchronization increases mitotic yield in human glioma cell lines. 
  • In situ hybridization and translocation breakpoint mapping. I. Nonidentical 22q11 breakpoints for the t(9;22) of CML and the t(8;22) of Burkitt lymphoma. 
  • Intracerebral transplantation of a human glioma line in immunosuppressed rats. 
  • Is the aneuploid chromosome in an apomictic Boechera holboellii a genuine B chromosome? 
  • Isolation and characterization of a novel human bladder cancer cell line: BK10. 
  • Isolation and characterization of a novel human prostatic stromal cell culture: DuK50. 
  • Isolation of a human teratoma cell line which expresses F9 antigen. 
  • Karyotypic abnormalities create discordance of germline genotype and cancer cell phenotypes. 
  • Karyotyping of Cryptococcus neoformans as an epidemiological tool. 
  • Lineage-specific trisomy 21 in a neonate with resolving transient myeloproliferative syndrome. 
  • Loss of centromere function drives karyotype evolution in closely related Malassezia species. 
  • Loss of chromosomes 22 and 14 in the malignant progression of meningiomas. A comparative study of fluorescence in situ hybridization (FISH) and standard cytogenetic analysis. 
  • Loss of the mismatched human leukocyte antigen haplotype in two acute myelogenous leukemia relapses after haploidentical bone marrow transplantation with post-transplantation cyclophosphamide. 
  • MYC/BCL2 double-hit high-grade B-cell lymphoma. 
  • Malignant rhabdoid tumor of the kidney: involvement of chromosome 22. 
  • Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species. 
  • Mild fetal ventriculomegaly: diagnosis, evaluation, and management. 
  • Molecular analysis of recombination in a family with Duchenne muscular dystrophy and a large pericentric X chromosome inversion. 
  • Molecular and genetic characterization of a radiation-induced structural rearrangement in mouse chromosome 2 causing mutations at the limb deformity and agouti loci. 
  • Molecular cytogenetic analysis of the bladder carcinoma cell line BK-10 by spectral karyotyping. 
  • Morphologic and molecular genetic aspects of oligodendroglial neoplasms. 
  • Mutational profiling of therapy-related myelodysplastic syndromes and acute myeloid leukemia by next generation sequencing, a comparison with de novo diseases. 
  • Non-immune hydrops after 20 weeks' gestation: review of 10 years' experience with suggestions for management. 
  • Omphalocele: clinical outcomes in cases with normal karyotypes. 
  • Outcome of induction and postremission therapy in younger adults with acute myeloid leukemia with normal karyotype: a cancer and leukemia group B study. 
  • Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: a Cancer and Leukemia Group B study. 
  • Partial duplication of 4q12q13 leads to a mild phenotype. 
  • Persistence of the same Candida albicans strain despite fluconazole therapy. Documentation by pulsed-field gel electrophoresis. 
  • Phenotypic and genotypic analysis of a human medulloblastoma cell line and transplantable xenograft (D341 Med) demonstrating amplification of c-myc. 
  • Physical maps for genome analysis of serotype A and D strains of the fungal pathogen Cryptococcus neoformans. 
  • Polycystic kidney disease as a result of loss of the tuberous sclerosis 2 tumor suppressor gene during development. 
  • Polytene chromosomal maps of 11 Drosophila species: the order of genomic scaffolds inferred from genetic and physical maps. 
  • Prenatal diagnosis and management of massive bilateral axillary cystic lymphangioma. 
  • Prenatal diagnosis of 45,X/46,XX mosaicism and 45,X: implications for postnatal outcome. 
  • Prenatal diagnosis of tetrasomy 9p. 
  • Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461). 
  • Primary brain tumours in Fischer 344 rats chronically exposed to acrylonitrile in their drinking-water. 
  • Production and characterization of two ependymoma xenografts. 
  • Prognostic and biologic significance of DNMT3B expression in older patients with cytogenetically normal primary acute myeloid leukemia. 
  • Prolonged subcutaneous administration of recombinant alpha 2b interferon in patients with previously untreated Philadelphia chromosome-positive chronic-phase chronic myelogenous leukemia: effect on remission duration and survival: Cancer and Leukemia Group B study 8583. 
  • Rapid detection of submicroscopic chromosomal rearrangements in children with multiple congenital anomalies using high density oligonucleotide arrays. 
  • Regional localization of the human genes for S-adenosylhomocysteine hydrolase (cen----q131) and adenosine deaminase (q131----qter) on chromosome 20. 
  • Regulation of cytochrome c oxidase subunit 1 (COX1) expression in Cryptococcus neoformans by temperature and host environment. 
  • Relationship between gene amplification and chromosomal deviations in malignant human gliomas. 
  • Reversion from deficiency of galactose-1-phosphate uridylytransferase (GALT) in an SV40-transformed human fibroblast line. 
  • Ring chromosome 17: phenotype variation by deletion size. 
  • Risk of preeclampsia in second-trimester triploid pregnancies. 
  • SNP array-based analyses of unbalanced embryos as a reference to distinguish between balanced translocation carrier and normal blastocysts. 
  • Secondary acute myeloid leukemia in children treated for acute lymphoid leukemia. 
  • Secondary myelodysplasia and acute leukemia in breast cancer patients after autologous bone marrow transplant. 
  • Separation of chromosomes of Cryptococcus neoformans by pulsed field gel electrophoresis. 
  • Severe combined immunodeficiency with natural killer-cell predominance: abrogation of graft-versus-host disease and immunologic reconstitution with HLA-identical bone marrow cells. 
  • Specific chromosomal abnormalities characterize four established cell lines derived from malignant human gliomas. 
  • Specific chromosomal abnormalities in malignant human gliomas. 
  • Spontaneous metastasis of cells of the human prostate carcinoma cell line PC-3 in athymic nude mice. 
  • Spontaneous resolution of a cystic neck mass in a fetus with normal karyotype. 
  • Structural chromosomal abnormalities in human medulloblastoma. 
  • Subtelomeric deletions of chromosome 6p: molecular and cytogenetic characterization of three new cases with phenotypic overlap with Ritscher-Schinzel (3C) syndrome. 
  • Suppression of tumorigenicity of A549 lung adenocarcinoma cells by human chromosomes 3 and 11 introduced via microcell-mediated chromosome transfer. 
  • Surface proteins of a transitional carcinoma cell line (KS-31E). 
  • Synaptonemal complex complement of man in spreads of spermatocytes, with details of the sex chromosome pair. 
  • Synaptonemal complex karyotyping in spermatocytes of the Chinese hamster (Cricetulus griseus). III. Quantitative evaluation. 
  • Synchronous clear cell renal cell carcinoma and tubulocystic carcinoma: genetic evidence of independent ontogenesis and implications of chromosomal imbalances in tumor progression. 
  • Targeted long-read sequencing identifies missing disease-causing variation. 
  • Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. 
  • The actin gene from Cryptococcus neoformans: structure and phylogenetic analysis. 
  • The association of aneuploidy and unexplained elevated maternal serum alpha-fetoprotein. 
  • The biology of unknown primary tumors. 
  • The gene encoding the glutamate receptor subunit GluR5 is located on human chromosome 21q21.1-22.1 in the vicinity of the gene for familial amyotrophic lateral sclerosis. 
  • The murine Hox-2 cluster of homeo box containing genes maps distal on chromosome 11 near the tail-short (Ts) locus. 
  • The normal and neoplastic perineurium: a review. 
  • The tumor dormant state. Comparison of L5178Y cells used to establish dormancy with those that emerge after its termination. 
  • The use of chromosomal microarray for prenatal diagnosis. 
  • Therapy-related acute lymphoblastic leukemia without 11q23 abnormality: report of six cases and a literature review. 
  • Three probands with autistic disorder and isodicentric chromosome 15. 
  • Translocation (X;19) with involvement of the inactive X chromosome in oligoblastic granulocytic leukemia. 
  • Triploid mosaicism in a 45,X/69,XXY infant. 
  • Trisomy 15 associated with nonimmune hydrops. 
  • Trisomy 8 mosaicism: selective growth advantage of normal cells vs. growth disadvantage of trisomy 8 cells. 
  • Trisomy of rat chromosome 1 associated with mesothelial cell transformation. 
  • Turner phenotype in mother and daughter. 
  • Unbalanced translocation 46,XY,-15,+der(22)t(15;22)(q13;q11)pat: case report and review of the literature. 
  • Unique chromosomal rearrangement and mucin production in a novel salivary myoepithelial cell strain. 
  • Unusual chromosome architecture and behaviour at an HSR. 
  • Use of endo-vaginal ultrasound to optimize visualization of the distal fetal spine in breech presentations. 
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  Keywords of People

  • Lagoo, Anand Shreeram, Professor of Pathology, Pathology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology