Keratins

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  Subject Areas on Research

  • A panel of antibodies useful in the cytologic diagnosis of metastatic melanoma. 
  • A radiologic sign of epidermolytic hyperkeratosis. 
  • A structural comparison of tryptic fragments of three types of intermediate filaments. 
  • An immunohistochemical comparison of cytokeratin 7, cytokeratin 15, cytokeratin 19, CAM 5.2, carcinoembryonic antigen, and nestin in differentiating porocarcinoma from squamous cell carcinoma. 
  • Analysis of corneal and conjunctival microenvironments using monoclonal antibodies. 
  • Analysis of micrometastatic disease in sentinel lymph nodes from resectable colon cancer: results of Cancer and Leukemia Group B Trial 80001. 
  • Analysis of neurogenesis in a mammalian neuroepithelium: proliferation and differentiation of an olfactory neuron precursor in vitro. 
  • Aneuploid subpopulations in tumour-invaded lymph nodes from breast cancer patients. 
  • Antibody against T lymphoblastic leukemia-associated antigen (3-40) identifies vimentin and keratin intermediate filaments in normal cells. 
  • Are metaplasias in colorectal adenomas truly metaplasias? 
  • Arsenic exposure of rural populations from the Rift Valley of Ethiopia as monitored by keratin in toenails. 
  • Asymmetric cell divisions promote stratification and differentiation of mammalian skin. 
  • Basal cell-signet-ring squamous cell carcinoma of the eyelid. 
  • Basal-like cells constitute the proliferating cell population in cystic fibrosis airways. 
  • Cadmium-induced neoplastic transformation of human prostate epithelial cells. 
  • Characterization of a monoclonal antibody, RTE-21, that binds to keratohyalin granule-associated proteins in epithelial cells of human skin and thymus. 
  • Characterization of cultured thymus tissue used for transplantation with emphasis on promiscuous expression of thyroid tissue-specific genes. 
  • Characterization of keratinocyte plasminogen activator inhibitors and demonstration of the prevention of pemphigus IgG-induced acantholysis by a purified plasminogen activator inhibitor. 
  • Characterization of potential precursor populations in the mouse olfactory epithelium using immunocytochemistry and autoradiography. 
  • Characterization of prostatic epithelial cell lines derived from transgenic adenocarcinoma of the mouse prostate (TRAMP) model. 
  • Cloning and characterization of cytokeratins 8 and 19 in adult rat striated muscle. Interaction with the dystrophin glycoprotein complex. 
  • Co-expression of vimentin and cytokeratins in parietal endoderm cells of early mouse embryo. 
  • Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi. 
  • Complete sequence of a gene encoding a human type I keratin: sequences homologous to enhancer elements in the regulatory region of the gene. 
  • Corticosteroids regulate epithelial cell differentiation and Hassall body formation in the human thymus. 
  • Cytokeratin 12 in human ocular surface epithelia is the antigen reactive with a commercial anti-Galpha q antibody. 
  • Desmoplakin I and desmoplakin II. Purification and characterization. 
  • Desmoplakin controls microvilli length but not cell adhesion or keratin organization in the intestinal epithelium. 
  • Differential effects of interleukin-1 alpha, tumor necrosis factor-alpha, indomethacin, hydrocortisone, and macrophage co-culture on the proliferation of human fibroblasts and peritoneal mesothelial cells. 
  • Differential localization of placental extracellular superoxide dismutase as pregnancy progresses. 
  • Ductal epithelial proliferations of the breast: a biological continuum? Comparative genomic hybridization and high-molecular-weight cytokeratin expression patterns. 
  • Dynamic evolution of the alpha (α) and beta (β) keratins has accompanied integument diversification and the adaptation of birds into novel lifestyles. 
  • Electron immunocytochemical analysis of posterior hyaloid associated with diabetic macular edema. 
  • Endothelial metaplasia in the iridocorneal endothelial syndrome. 
  • Epidermal keratinocytes express the adhesion molecule intercellular adhesion molecule-1 in inflammatory dermatoses. 
  • Evaluation of squamous epithelium in adenoacanthoma and adenosquamous carcinoma of the endometrium: immunoperoxidase analysis of involucrin and keratin localization. 
  • Expression of specific keratin markers by rabbit corneal, conjunctival, and esophageal epithelia during vitamin A deficiency. 
  • Expression of unusually large keratins during terminal differentiation: balance of type I and type II keratins is not disrupted. 
  • Extrusion of abnormal endothelium into the posterior corneal stroma in a patient with posterior polymorphous dystrophy. 
  • Feather development genes and associated regulatory innovation predate the origin of Dinosauria. 
  • Fine-needle aspiration of primary gallbladder carcinoma. 
  • Fine-needle-aspiration cytology of a proximal type epithelioid sarcoma: A case report. 
  • Goblet-cell mucinous epithelium lining the endometrium and endocervix: evidence of metastasis from an appendiceal primary tumor through the use of cytokeratin-7 and -20 immunostains. 
  • High yield reproducible rat model recapitulating human Barrett's carcinogenesis. 
  • Human colorectal carcinomas specifically accumulate Mr 42,000 ubiquitin-conjugated cytokeratin 8 fragments. 
  • Immunohistochemical analysis of the pathogenesis of posterior polymorphous dystrophy. 
  • Immunohistochemical differentiation of sarcomatoid mesotheliomas from other spindle cell neoplasms. 
  • Immunohistochemistry of the canine vomeronasal organ. 
  • Immunohistochemistry of the canine vomeronasal organ. 
  • Immunophenotype and molecular characterisation of adenocarcinoma of the small intestine. 
  • Increased production of sonic hedgehog by ballooned hepatocytes. 
  • Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle. 
  • Integration of peripheral blood biomarkers with computed tomography to differentiate benign from malignant pulmonary opacities. 
  • Invited commentary. 
  • Isolation and characterization of biliary epithelial cells from rainbow trout liver. 
  • Keratin Profiling by Single-Cell RNA-Sequencing Identifies Human Prostate Stem Cell Lineage Hierarchy and Cancer Stem-Like Cells. 
  • Long-term primary culture of epithelial cells from rainbow trout Oncorhynchus mykiss) liver. 
  • Lysosomes and the skin. 
  • Lysosomes and the skin. 
  • Malignant mesothelioma with heterologous elements: clinicopathological correlation of 27 cases and literature review. 
  • Migrating keratinocytes express urokinase-type plasminogen activator. 
  • Milium-like syringoma: a case study on histogenesis. 
  • Molecular characterization of chordoma xenografts generated from a novel primary chordoma cell source and two chordoma cell lines. 
  • Molecular mechanisms of development of the human fetal female reproductive tract. 
  • Monoclonal antibody 4F2 reactive with basal layer keratinocytes: studies in the normal and a hyperproliferative state. 
  • Mouse keratin 4 is necessary for internal epithelial integrity. 
  • Multiply recurrent trichilemmal carcinoma with perineural invasion and cytokeratin 17 positivity. 
  • Ontogeny of the human thymus during fetal development. 
  • Parent-specific expression of a human keratin 18/beta-galactosidase fusion gene in transgenic mice. 
  • Partial hepatectomy and bile duct ligation in rainbow trout (Oncorhynchus mykiss): histologic, immunohistochemical and enzyme histochemical characterization of hepatic regeneration and biliary hyperplasia. 
  • Phenotypic characterization and ontogeny of mesodermal-derived and endocrine epithelial components of the human thymic microenvironment. 
  • Polypoid tumor of the esophagus. 
  • Preneoplastic and neoplastic lesions of rat hereditary renal cell tumors express markers of proximal and distal nephron. 
  • Progesterone receptor activity in leiomyomatosis peritonealis disseminata. 
  • Proteomic analysis of desmosomes reveals novel components required for epidermal integrity. 
  • Pulmonary carcinomas with a sarcomatoid element: an immunocytochemical and ultrastructural analysis. 
  • Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. 
  • Regulation of apoptosis in normal and malignant ovarian epithelial cells by transforming growth factor beta. 
  • Remarkable conservation of structure among intermediate filament genes. 
  • Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. 
  • Sarcomatoid Peritoneal Mesothelioma: Clinicopathologic Correlation of 13 Cases. 
  • Serum CYFRA 21-1 in advanced stage non-small cell lung cancer: an early measure of response. 
  • Suppression of endo B cytokeratin by its antisense RNA inhibits the normal coexpression of endo A cytokeratin. 
  • The diagnostic distinction between malignant mesothelioma of the pleura and adenocarcinoma of the lung as defined by a monoclonal antibody (B72.3). 
  • The human keratin genes and their differential expression. 
  • The human thymic microenvironment during organ culture. 
  • The human thymic microenvironment. Phenotypic characterization of Hassall's bodies with the use of monoclonal antibodies. 
  • The human thymic microenvironment: thymic epithelium contains specific keratins associated with early and late stages of epidermal keratinocyte maturation. 
  • The human thymus. A chimeric organ comprised of central and peripheral lymphoid components. 
  • The nature and significance of differential keratin gene expression. 
  • The thymic microenvironment. Characterization of in vitro differentiation of the IT26R21 rat thymic epithelial cell line. 
  • The undifferentiated malignant neoplasm. Identification of lymphoma arising in skeletal muscle by immunohistochemical analysis. 
  • The use of a panel of monoclonal antibodies in ultrastructurally characterized small cell carcinomas of the lung. 
  • Three tightly linked genes encoding human type I keratins: conservation of sequence in the 5'-untranslated leader and 5'-upstream regions of coexpressed keratin genes. 
  • Type I and type II keratins have evolved from lower eukaryotes to form the epidermal intermediate filaments in mammalian skin. 
  • Visualization of a 21-nm axial periodicity in shadowed keratin filaments and neurofilaments. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor for Research in Molecular Biology, Cell Biology
  • Moorman, Patricia Gripka, Professor Emeritus in Family Medicine and Community Health, Duke Cancer Institute