Ketamine

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  Subject Areas on Research

  • A Common Neuroendocrine Substrate for Diverse General Anesthetics and Sleep. 
  • A randomized, double blind, placebo controlled clinical trial of the preoperative use of ketamine for reducing inflammation and pain after thoracic surgery. 
  • Altered prefrontal dopaminergic function in chronic recreational ketamine users. 
  • Analgesia in the surgical intensive care unit. 
  • Brain-wide Electrical Spatiotemporal Dynamics Encode Depression Vulnerability. 
  • COG1410, a novel apolipoprotein-E mimetic, improves functional and morphological recovery in a rat model of focal brain ischemia. 
  • Can a Framework Be Established for the Safe Use of Ketamine? 
  • Clinical Policy: Critical Issues in the Diagnosis and Management of the Adult Psychiatric Patient in the Emergency Department. 
  • Clinical policy: procedural sedation and analgesia in the emergency department. 
  • Comparison of seizure duration, ictal EEG, and cognitive effects of ketamine and methohexital anesthesia with ECT. 
  • Concurrent use of methamphetamine, MDMA, LSD, ketamine, GHB, and flunitrazepam among American youths. 
  • Current medication practice and tracheal intubation safety outcomes from a prospective multicenter observational cohort study. 
  • Deliberate seizure induction with repetitive transcranial magnetic stimulation in nonhuman primates. 
  • Differential effects of cocaine and ketamine on time estimation: implications for neurobiological models of interval timing. 
  • Does ketamine-mediated N-methyl-D-aspartate receptor antagonism cause schizophrenia-like oculomotor abnormalities? 
  • Effect of neonatal diethylstilbestrol exposure on luteinizing hormone secretion following ketamine anesthesia and gonadotropin-releasing hormone in castrated postpubertal rats. 
  • Effect of rifampicin on S-ketamine and S-norketamine plasma concentrations in healthy volunteers after intravenous S-ketamine administration. 
  • Effects of glycine receptor antagonism on spreading depression in the rat. 
  • Effects of isoflurane, ketamine, and fentanyl/N2O on concentrations of brain and plasma catecholamines during near-complete cerebral ischemia in the rat. 
  • Effects of ketamine on outcome from temporary middle cerebral artery occlusion in the spontaneously hypertensive rat. 
  • Efficacy and safety of ketamine in patients with complex regional pain syndrome: a systematic review. 
  • Estimation of the contribution of norketamine to ketamine-induced acute pain relief and neurocognitive impairment in healthy volunteers. 
  • Field methods for capture and measurement of three monkey species in Costa Rica. 
  • Halogen Substitution Influences Ketamine Metabolism by Cytochrome P450 2B6: In Vitro and Computational Approaches. 
  • Impaired growth and force production in skeletal muscles of young partially pancreatectomized rats: a model of adolescent type 1 diabetic myopathy? 
  • Impaired hippocampal-dependent memory and reduced parvalbumin-positive interneurons in a ketamine mouse model of schizophrenia. 
  • Intravenous Ketamine Relieves Pain and Depression After Traumatic Suicide Attempts: A Case Series. 
  • Investigations on spinal cord fMRI of cats under ketamine. 
  • Ketamine "unlocks" the reduced clock-speed effects of cocaine following extended training: evidence for dopamine--glutamate interactions in timing and time perception. 
  • Ketamine ("Ketalar"): a safer anaesthetic for ECT. 
  • Ketamine activates breathing and abolishes the coupling between loss of consciousness and upper airway dilator muscle dysfunction. 
  • Ketamine and ketamine metabolites as novel estrogen receptor ligands: Induction of cytochrome P450 and AMPA glutamate receptor gene expression. 
  • Ketamine as a probe for medetomidine stereoisomer inhibition of human liver microsomal drug metabolism. 
  • Ketamine in the Prehospital Environment: A National Survey of Paramedics in the United States. 
  • Ketamine potentiates oxidative stress and influences behavior and inflammation in response to lipolysaccharide (LPS) exposure in early life. 
  • Low-Dose Ketamine Infusion to Decrease Postoperative Delirium for Spinal Fusion Patients. 
  • Metabolism of ketamine stereoisomers by human liver microsomes. 
  • Metabolomic signatures of drug response phenotypes for ketamine and esketamine in subjects with refractory major depressive disorder: new mechanistic insights for rapid acting antidepressants. 
  • Molecular recognition of ketamine by a subset of olfactory G protein-coupled receptors. 
  • Neuroanesthesia Guidelines for Optimizing Transcranial Motor Evoked Potential Neuromonitoring During Deformity and Complex Spinal Surgery: A Delphi Consensus Study. 
  • Nicotine oxidation by genetic variants of CYP2B6 and in human brain microsomes. 
  • Ninety-six hour ketamine infusion with co-administered clonidine for treatment-resistant depression: A pilot randomised controlled trial. 
  • Not So Fast: Recent Successes and Failures in Treating Depression. 
  • Paediatric regional anaesthesia--what makes a difference? 
  • Perioperative Ketamine Administration for Thoracotomy Pain. 
  • Pharmacogenetics of Ketamine-Induced Emergence Phenomena: A Pilot Study. 
  • Psychedelic effects of ketamine in healthy volunteers: relationship to steady-state plasma concentrations. 
  • Psychosis and ketamine. 
  • Psychosis and ketamine. 
  • Rapid relief of severe major depressive disorder by use of preoperative ketamine and electroconvulsive therapy. 
  • Repeated ketamine infusions for antidepressant-resistant PTSD: Methods of a multicenter, randomized, placebo-controlled clinical trial. 
  • Role of Cytochrome P4502B6 Polymorphisms in Ketamine Metabolism and Clearance. 
  • Safety in Acute Pain Medicine-Pharmacologic Considerations and the Impact of Systems-Based Gaps. 
  • Speed of response to electroconvulsive therapy compared with ketamine. 
  • Stereoselective Ketamine Metabolism by Genetic Variants of Cytochrome P450 CYP2B6 and Cytochrome P450 Oxidoreductase. 
  • Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord. 
  • Sub-anesthetic doses of ketamine attenuate nicotine self-administration in rats. 
  • The influence of different concentrations of volatile anesthetics on the threshold for cortical spreading depression in rats. 
  • The inhibition of the kynurenine pathway prevents behavioral disturbances and oxidative stress in the brain of adult rats subjected to an animal model of schizophrenia. 
  • Updates on Preclinical and Translational Neuroscience of Mood Disorders: A Brief Historical Focus on Ketamine for the Clinician. 
  • Use of ketamine during procedural sedation: indications, controversies, and side effects. 
  • [Effect of intrathecal katemine on the expression of nNOS in spinal dorsal horn in rats with formalin pain]. 
  • [Effects of intravenous anesthetics on LPS-induced production of tumour necrosis factor-alpha from primary cultures of rat glial cells in vitro]. 
  • [Three subanaesthetic dose ketamines mixed with butorphanol in the postoperative continuous intravenous analgesia]. 
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  Keywords of People

  • Der, Tatyana, Medical Instructor in the Department of Medicine, Medicine, General Internal Medicine
  • Warner, David Samuel, Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology
  • Wu, Li-Tzy, Professor in Psychiatry and Behavioral Sciences, Medicine, General Internal Medicine