Ketones

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  Subject Areas on Research

  • 2-Azadienes as Reagents for Preparing Chiral Amines: Synthesis of 1,2-Amino Tertiary Alcohols by Cu-Catalyzed Enantioselective Reductive Couplings with Ketones. 
  • A low-carbohydrate, ketogenic diet versus a low-fat diet to treat obesity and hyperlipidemia: a randomized, controlled trial. 
  • A spectrophotometric glutathione S-transferase assay displaying alpha-class selectivity utilizing 1-p-chlorophenyl-4,4-dimethyl-5-diethylamino-1-penten-3- one hydrobromide. 
  • Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogen. 
  • Analysis of n-hexane, 2-hexanone, 2,5-hexanedione, and related chemicals by capillary gas chromatography and high-performance liquid chromatography. 
  • Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis. 
  • Catalytic enantioselective alkylation of substituted dioxanone enol ethers: ready access to Calpha-tetrasubstituted hydroxyketones, acids, and esters. 
  • Chemico-Biological Interactions. Enzymology and molecular biology of carbonyl metabolism 16. Introduction. 
  • Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels. 
  • Cross-linking of neurofilament proteins of rat spinal cord in vivo after administration of 2,5-hexanedione. 
  • Cytoskeletal proteins as targets for organophosphorus compound and aliphatic hexacarbon-induced neurotoxicity. 
  • Diet therapy for narcolepsy. 
  • Disposition, pharmacokinetics, and metabolism of a dermal dose of [14C]2,5-hexanedione in hens. 
  • Do Surface Porosity and Pore Size Influence Mechanical Properties and Cellular Response to PEEK? 
  • Electron paramagnetic resonance studies of iron reduction and semiquinone formation in metalloflavoproteins. 
  • Enantioselective Intermolecular Pd-Catalyzed Hydroalkylation of Acyclic 1,3-Dienes with Activated Pronucleophiles. 
  • Enantioselective decarboxylative alkylation reactions: catalyst development, substrate scope, and mechanistic studies. 
  • Evidence for multiple mechanisms responsible for 2,5-hexanedione-induced neuropathy. 
  • Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta. 
  • Gene therapy for diabetes mellitus in rats by hepatic expression of insulin. 
  • Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression. 
  • High-strength, surface-porous polyether-ether-ketone for load-bearing orthopedic implants. 
  • Impaction durability of porous polyether-ether-ketone (PEEK) and titanium-coated PEEK interbody fusion devices. 
  • Initial testing (stage 1) of eribulin, a novel tubulin binding agent, by the pediatric preclinical testing program. 
  • Interaction between neurotoxicities induced by organophosphorus and long-chain hexacarbon compounds. 
  • Isocoproporphyrin: nuclear-magnetic-resonance-and mass-spectral methods for the determination of porphyrin structure. 
  • Local deformation behavior of surface porous polyether-ether-ketone. 
  • Luminescent Difluoroboron β-Diketonate PLA-PEG Nanoparticle. 
  • Metabolic profiles predict adverse events after coronary artery bypass grafting. 
  • Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs. 
  • Neurotoxic effects of combined treatment of 2,5-hexanedione and triethyllead chloride. 
  • Neurotoxicity of continuous (90 days) inhalation of technical grade methyl butyl ketone in hens. 
  • Ozone-initiated chemistry in an occupied simulated aircraft cabin. 
  • Pattern of neurotoxicity of n-hexane, methyl n-butyl ketone, 2,5-hexanediol, and 2,5-hexanedione alone and in combination with O-ethyl O-4-nitrophenyl phenylphosphonothioate in hens. 
  • Race and sex differences in small-molecule metabolites and metabolic hormones in overweight and obese adults. 
  • Stereoselective synthesis of 2,6-trans-tetrahydropyran via primary diamine-catalyzed oxa-conjugate addition reaction of α,β-unsaturated ketone: total synthesis of psymberin. 
  • Structural requirements for high affinity ligand binding by estrogen receptors: a comparative analysis of truncated and full length estrogen receptors expressed in bacteria, yeast, and mammalian cells. 
  • Studies of the molecular pathogenesis of hexane neuropathy. I. evaluation of the inhibition of glyceraldehyde-3-phosphate dehydrogenase by 2,5-hexanedione. 
  • THE INDO-US COLLABORATIVE HEAD INJURY AND ADHERENCE TO GUIDELINES (CHIRAG) PROJECT: OUTCOMES AND FEASIBILITY 
  • The effect of a low-carbohydrate, ketogenic diet on nonalcoholic fatty liver disease: a pilot study. 
  • The effects of varying dietary carbohydrate and fat content on survival in a murine LNCaP prostate cancer xenograft model. 
  • The joint neurotoxic action of inhaled methyl butyl ketone vapor and dermally applied O-ethyl O-4-nitrophenyl phenylphosphonothioate in hens: potentiating effect. 
  • The relative neurotoxicities of n-hexane, methyl n-butyl ketone, 2,5-hexanediol, and 2,5-hexanedione following oral or intraperitoneal administration in hens. 
  • The synergism of n-hexane-induced neurotoxicity by methyl isobutyl ketone following subchronic (90 days) inhalation in hens: induction of hepatic microsomal cytochrome P-450. 
  • Vapor detection and discrimination with a panel of odorant receptors. 
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  Keywords of People

  • Hirschey, Matthew, Associate Professor, Pharmacology & Cancer Biology
  • Yancy Jr., William Samuel, Associate Professor of Medicine, Medicine, General Internal Medicine