Kidney Glomerulus

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  Subject Areas on Research

  • 4D in vivo imaging of glomerular barrier function in a zebrafish podocyte injury model. 
  • A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. 
  • A proposed taxonomy for the podocytopathies: a reassessment of the primary nephrotic diseases. 
  • A receptor for activated C3 in the human renal glomerular capillary wall. 
  • A receptor for the third component of complement in the human renal glomerulus. 
  • Absence of tubuloglomerular feedback responses in AT1A receptor-deficient mice. 
  • Acute mycotoxicosis in sheep: field cases. 
  • Alemtuzumab induction and recurrence of glomerular disease after kidney transplantation. 
  • Angiotensinogen gene null-mutant mice lack homeostatic regulation of glomerular filtration and tubular reabsorption. 
  • Anti-DNA antibodies form immune deposits at distinct glomerular and vascular sites. 
  • Anti-laminin reactivity and glomerular immune deposition by in vitro recombinant antibodies. 
  • Basement membranes and autoimmune diseases. 
  • Beneficial effects of the Rho kinase inhibitor Y27632 in murine puromycin aminonucleoside nephrosis. 
  • COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness. 
  • Calcineurin (CN) activation promotes apoptosis of glomerular podocytes both in vitro and in vivo. 
  • Case for the panel Nephrotic syndrome with fibrillary and lipid deposits. 
  • Changes in glomerular kidney function among HIV-1-uninfected men and women receiving emtricitabine-tenofovir disoproxil fumarate preexposure prophylaxis: a randomized clinical trial. 
  • Characterization of angiotensin II-receptor subtypes in podocytes. 
  • Characterization of glomerular thromboxane receptors in murine lupus nephritis. 
  • Chorioallantoic membrane grafting of the embryonic murine kidney. An improved in vitro technique for studying kidney morphogenesis. 
  • Clinical and pathologic features of familial focal segmental glomerulosclerosis. 
  • Cogan's syndrome and development of ANCA-associated renal vasculitis after lengthy disease remission. 
  • Collapsing glomerulopathy in 19 patients with systemic lupus erythematosus or lupus-like disease. 
  • Collapsing glomerulopathy: an inflammatory podocytopathy? 
  • Cryoglobulinemia and glomerular rhomboid inclusions in a child with acute kidney injury. 
  • Cultured glomerular mesangial cells contain renin: influence of calcium and isoproterenol. 
  • Current views on collapsing glomerulopathy. 
  • Cytoskeletal regulation of TRPC channels in the cardiorenal system. 
  • Differential renal distribution of NHERF isoforms and their colocalization with NHE3, ezrin, and ROMK. 
  • Directed differentiation of human induced pluripotent stem cells into mature kidney podocytes and establishment of a Glomerulus Chip. 
  • Electron microscopic virus-like material in systemic lupus erythematosus: with preliminary immunologic observations on presence of measles antigen. 
  • Electron-dense deposits in extraglomerular vascular structures in IgA nephropathy. A retrospective study. 
  • Experimental transfusion reactions in monkeys: haemolytic, coagulant and renal effects of transfused isoimmune IgG and IgM. 
  • Fate of four cadaveric donor renal allografts with mesangial IgA deposits. 
  • Feasibility of renal transplantation in systemic lupus erythematosus. 
  • From man to fish: What can Zebrafish tell us about ApoL1 nephropathy? 
  • Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. 
  • Glomerular atrial natriuretic factor receptors in primary glomerulopathies: studies on human renal biopsies. 
  • Glomerular beta-galactosidase expression following transduction with microsphere-adenoviral complexes. 
  • Glomerular grievances and CKD. 
  • Gonadectomy prevents the increase in blood pressure and glomerular injury in angiotensin-converting enzyme 2 knockout diabetic male mice. Effects on renin-angiotensin system. 
  • Gq signaling causes glomerular injury by activating TRPC6. 
  • HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN. 
  • HIV-1 induces renal epithelial dedifferentiation in a transgenic model of HIV-associated nephropathy. 
  • Identification of a protective proteomic signature and a potential therapeutic target in diabetic nephropathy. 
  • Idiopathic collapsing focal segmental glomerulosclerosis: a clinicopathologic study. 
  • Immunopathologic studies of an experimental model resembling Goodpasture's syndrome. 
  • In vivo Modeling Implicates APOL1 in Nephropathy: Evidence for Dominant Negative Effects and Epistasis under Anemic Stress. 
  • Increased glomerular deposits of von Willebrand factor in chronic, but not acute, rejection of primate renal allografts. 
  • Independently derived murine glomerular immune deposit-forming anti-DNA antibodies are encoded by near-identical VH gene sequences. 
  • Inducible podocyte injury and proteinuria in transgenic zebrafish. 
  • Inhibition of adenosine-1 receptor-mediated preglomerular vasoconstriction in AT1A receptor-deficient mice. 
  • Instantaneous and steady-state gains in the tubuloglomerular feedback system. 
  • Integrative Genomics Identifies Novel Associations with APOL1 Risk Genotypes in Black NEPTUNE Subjects. 
  • Involvement of R-cadherin in the early stage of glomerulogenesis. 
  • Kidney lesions in Rocky Mountain spotted fever: a light-, immunofluorescence-, and electron-microscopic study. 
  • Laser-capture microdissection. 
  • Localization of receptors for activated complement on visceral epithelial cells of the human renal glomerulus. 
  • Lupus autoantibodies interact directly with distinct glomerular and vascular cell surface antigens. 
  • Lupus nephritis: update on pathogenesis and disease mechanisms. 
  • Magnetic resonance histology of age-related nephropathy in the Sprague Dawley rat. 
  • Management of glomerular proteinuria: a commentary. 
  • Mitomycin-induced hemolytic-uremic syndrome. 
  • Modulation of renal disease in autoimmune NZB/NZW mice by immunization with bacterial DNA. 
  • Morphometry Predicts Early GFR Change in Primary Proteinuric Glomerulopathies: A Longitudinal Cohort Study Using Generalized Estimating Equations. 
  • Multistability in tubuloglomerular feedback and spectral complexity in spontaneously hypertensive rats. 
  • Murine monoclonal anti-DNA antibodies penetrate cells, bind to nuclei, and induce glomerular proliferation and proteinuria in vivo. 
  • Mycophenolate mofetil suppresses autoimmunity and mortality in the female NZB x NZW F1 mouse model of systemic lupus erythematosus. 
  • Myo1c is an unconventional myosin required for zebrafish glomerular development. 
  • Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways. 
  • Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways. 
  • Neutrophils, monocytes, and lymphocytes bind to cytokine-activated kidney glomerular endothelial cells through L-selectin (LAM-1) in vitro. 
  • Organized deposits in the kidney and look-alikes. 
  • Parathyroid hormone effects on serum 1,25-dihydroxyvitamin D levels in patients with X-linked hypophosphatemic rickets: evidence for abnormal 25-hydroxyvitamin D-1-hydroxylase activity. 
  • Pathology of disseminated intravascular coagulation (DIC). Analysis of 26 cases. 
  • Podocan, a novel small leucine-rich repeat protein expressed in the sclerotic glomerular lesion of experimental HIV-associated nephropathy. 
  • Podocyte biology and the emerging understanding of podocyte diseases. 
  • Podocyte biology in segmental sclerosis and progressive glomerular injury. 
  • Podocyte cell cycle regulation and proliferation in collapsing glomerulopathies. 
  • Prevalence and clinical correlates of glomerulopathy in children with sickle cell disease. 
  • Progressive glomerular toxicity of ifosfamide in children. 
  • Proliferative glomerulonephritis in children. A correlation of varied clinical and pathologic patterns utilizing light, immunofluorescence, and electron microscopy. 
  • Real-time quantitative elemental analysis and mapping: microchemical imaging in cell physiology. 
  • Regulation of cofilin phosphorylation in glomerular podocytes by testis specific kinase 1 (TESK1). 
  • Regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF-A) expression in podocytes. 
  • Renal allografts in HL-A matched recipients. Light, immunofluorescence and electron microscopic studies. 
  • Renal growth and development in mice lacking AT1A receptors for angiotensin II. 
  • Renal pathology patterns in type II diabetes mellitus: relationship with retinopathy. The Collaborative Study Group. 
  • Renal transplantation between histocompatible donor-recipient pairs. 
  • Renal tubular ACE-mediated tubular injury is the major contributor to microalbuminuria in early diabetic nephropathy. 
  • Renal tubular insufficiency, cholestatic jaundice, and multiple congenital anomalies--a new multisystem syndrome. 
  • Rescue thrombolysis: resolution of intraglomerular thrombi after donation after circulatory death. 
  • Resolution of primary amyloidosis during chemotherapy. Studies in a patient with nephrotic syndrome. 
  • Revisiting the determinants of the glomerular filtration barrier: what goes round must come round. 
  • Signal transduction in a compliant short loop of Henle. 
  • Targeted gene therapy for rat glomerulonephritis using HVJ-immunoliposomes. 
  • The Application of Digital Pathology to Improve Accuracy in Glomerular Enumeration in Renal Biopsies. 
  • The dysregulated podocyte phenotype: a novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated nephropathy. 
  • The effects of surgery and acute rejection on glomerular hemodynamics in the transplanted rat kidney. 
  • The glomerular complement receptor in immunologically mediated renal glomerular injury. 
  • The influence of variable-region somatic mutations on the specificity and pathogenicity of murine monoclonal anti-DNA antibodies. 
  • The nephrotic syndrome in congenital syphilis: an immunopathy. 
  • The uncertain significance of anti-glomerular basement membrane antibody among HIV-infected persons with kidney disease. 
  • Therapeutic targets in focal and segmental glomerulosclerosis. 
  • Thrombotic microangiopathy in anti-glomerular basement membrane glomerulonephritis. 
  • Thromboxane binding and signal transduction in rat glomerular mesangial cells. 
  • Tissue linkage through adjoining basement membranes: The long and the short term of it. 
  • Toward a mouse model of diabetic nephropathy: is endothelial nitric oxide synthase the missing link? 
  • Transactivation of the epidermal growth factor receptor by angiotensin II in glomerular podocytes. 
  • Transplant approach establishes that kidneys are responsible for serum CSF-1 but require a stimulus in MRL-lpr mice. 
  • Tumor necrosis factor-α produced in the kidney contributes to angiotensin II-dependent hypertension. 
  • Update in podocyte biology: putting one's best foot forward. 
  • Utilization of the chick chorioallantoic membrane for in vitro growth of the embryonic murine kidney. 
  • VEGF inhibition and renal thrombotic microangiopathy. 
  • Vasoconstrictor responses in thromboxane receptor knockout mice: tubuloglomerular feedback and ureteral obstruction. 
  • Widely disseminated Cunninghamella mucormycosis in an adult renal transplant patient: case report and review of the literature. 
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  Keywords of People

  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor, Cell Biology
  • Johnson, G. Allan, Charles E. Putman University Distinguished Professor of Radiology, Physics
  • Preminger, Glenn Michael, James F. Glenn, M.D. Distinguished Professor of Urology, Surgery