Kidney Tubules, Proximal

• 

  Subject Areas on Research

  • A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice. 
  • AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure. 
  • Absence of a role of gamma-glutamyl transpeptidase in the transport of amino acids by rat renal brushborder membrane vesicles. 
  • Activation of the Nlrp3 inflammasome by mitochondrial reactive oxygen species: a novel mechanism of albumin-induced tubulointerstitial inflammation. 
  • Administration of atrial natriuretic factor inhibits sodium-coupled transport in proximal tubules. 
  • Amelioration of proximal renal tubular dysfunction in type I glycogen storage disease with dietary therapy. 
  • Aminoaciduria and altered renal expression of luminal amino acid transporters in mice lacking novel gene collectrin. 
  • Angiotensin II and hypertonicity modulate proximal tubular aquaporin 1 expression. 
  • Angiotensin receptors in the kidney and vasculature in hypertension and kidney disease. 
  • Anoxia induces phospholipase A2 activation in rabbit renal proximal tubules. 
  • Autocrine inhibition of Na+/K(+)-ATPase by nitric oxide in mouse proximal tubule epithelial cells. 
  • Characteristics of cystine uptake by cultured LLC-PK1 cells. 
  • Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchanger. 
  • Characterization of a putative insulin-responsive element and its binding protein(s) in rat angiotensinogen gene promoter: regulation by glucose and insulin. 
  • Chronic effects of nitrendipine on renal hemodynamics and tubular transport. 
  • Combined expression of A1 and A20 achieves optimal protection of renal proximal tubular epithelial cells. 
  • Congenital polycystic kidney disease. Genetically transmitted infantile polycystic kidney disease in C57BL/6J mice. 
  • Cytotoxicity of S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl) vinyl ether (Compound A) in a human proximal tubular cell line. 
  • Defective PTH regulation of sodium-dependent phosphate transport in NHERF-1-/- renal proximal tubule cells and wild-type cells adapted to low-phosphate media. 
  • Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice. 
  • Defective parathyroid hormone regulation of NHE3 activity and phosphate adaptation in cultured NHERF-1-/- renal proximal tubule cells. 
  • Dephosphorylation of ezrin as an early event in renal microvillar breakdown and anoxic injury. 
  • Determination of an angiotensin II-regulated proteome in primary human kidney cells by stable isotope labeling of amino acids in cell culture (SILAC). 
  • Developmental aspects of sugar transport by isolated dog renal cortical tubules. 
  • Differential renal distribution of NHERF isoforms and their colocalization with NHE3, ezrin, and ROMK. 
  • Effect of cystine dimethylester on renal solute handling and isolated renal tubule transport in the rat: a new model of the Fanconi syndrome. 
  • Effect of renin-angiotensin system blockade on the expression of the angiotensinogen gene and induction of hypertrophy in rat kidney proximal tubular cells. 
  • Elemental microanalysis of organelles in proximal tubules. I. Alterations in transport and metabolism. 
  • Elemental microanalysis of organelles in proximal tubules. II. Effects of oxygen deprivation. 
  • Essential role(s) of the intrarenal renin-angiotensin system in transforming growth factor-beta1 gene expression and induction of hypertrophy of rat kidney proximal tubular cells in high glucose. 
  • Ezrin binding domain-deficient NHERF attenuates cAMP-mediated inhibition of Na(+)/H(+) exchange in OK cells. 
  • Fibroblast growth factor-23-mediated inhibition of renal phosphate transport in mice requires sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) and synergizes with parathyroid hormone. 
  • Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle. 
  • Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers. 
  • Glucocorticoid metabolism in proximal tubules modulates angiotensin II-induced electrolyte transport. 
  • Growth factor-mediated phosphorylation of proapoptotic BAD reduces tubule cell death in vitro and in vivo. 
  • Guanosine triphosphate cyclohydrolase I regulates nitric oxide synthesis in renal proximal tubules. 
  • HIV-1 Vpr inhibits cytokinesis in human proximal tubule cells. 
  • Heme oxygenase-1 is upregulated in the kidney of angiotensin II-induced hypertensive rats : possible role in renoprotection. 
  • Heme: a novel inducer of MCP-1 through HO-dependent and HO-independent mechanisms. 
  • Heterogeneity of calcium compartmentation: electron probe analysis of renal tubules. 
  • High glucose stimulates angiotensinogen gene expression and cell hypertrophy via activation of the hexosamine biosynthesis pathway in rat kidney proximal tubular cells. 
  • High glucose stimulates angiotensinogen gene expression via reactive oxygen species generation in rat kidney proximal tubular cells. 
  • High levels of glucose stimulate angiotensinogen gene expression via the P38 mitogen-activated protein kinase pathway in rat kidney proximal tubular cells. 
  • Human proximal tubular cell responses to angiotensin II analyzed using DNA microarray. 
  • Hyperglycemia induces insulin resistance on angiotensinogen gene expression in diabetic rat kidney proximal tubular cells. 
  • Identification of calcium-calmodulin multifunctional protein kinase II in rabbit kidney. 
  • Immortalized rat proximal tubule cell lines expressing components of the renin-angiotensin system. 
  • Immortalized rat proximal tubule cells produce membrane bound and soluble megalin. 
  • In situ cryofixation of kidney for electron probe X-ray microanalysis. 
  • In situ hybridization evidence for angiotensinogen messenger RNA in the rat proximal tubule. An hypothesis for the intrarenal renin angiotensin system. 
  • Increased blood pressure in mice lacking cytochrome P450 2J5. 
  • Insulin inhibits angiotensinogen gene expression via the mitogen-activated protein kinase pathway in rat kidney proximal tubular cells. 
  • Insulin inhibits dexamethasone effect on angiotensinogen gene expression and induction of hypertrophy in rat kidney proximal tubular cells in high glucose. 
  • Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury. 
  • Light chains are a ligand for megalin. 
  • Localization and interaction of NHERF isoforms in the renal proximal tubule of the mouse. 
  • Long-acting natriuretic peptide, vessel dilator, and kaliuretic peptide enhance urinary excretion rate of albumin, total protein, and beta(2)-microglobulin in patients with congestive heart failure. 
  • Luminal alkalinization attenuates proteinuria-induced oxidative damage in proximal tubular cells. 
  • Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments. 
  • Megalin binds and internalizes angiotensin II. 
  • Metabolic inhibition-induced transient Ca2+ increase depends on mitochondria in a human proximal renal cell line. 
  • Molecular mechanisms of glucose action on angiotensinogen gene expression in rat proximal tubular cells. 
  • Multiple roles of calcium in anoxic-induced injury in renal proximal tubules. 
  • NHERF-1 uniquely transduces the cAMP signals that inhibit sodium-hydrogen exchange in mouse renal apical membranes. 
  • PTH transiently increases the percent mobile fraction of Npt2a in OK cells as determined by FRAP. 
  • Pathophysiology and Pathology of Acute Kidney Injury in Patients With COVID-19. 
  • Physiopathologic role of cubilin and megalin. 
  • Preneoplastic and neoplastic lesions of rat hereditary renal cell tumors express markers of proximal and distal nephron. 
  • Promotion by sodium barbital induces early development but does not increase the multiplicity of hereditary renal tumors in Eker rats. 
  • Protein kinase A, cytosolic calcium, and phosphate uptake in human proximal renal cells. 
  • Proteinuria causes dysfunctional autophagy in the proximal tubule. 
  • Rapamycin increases transforming growth factor-beta mRNA expression in immortalized rat proximal renal tubular cells. 
  • Rat proximal tubule cell line transformed with origin-defective SV40 DNA: autocrine ANG II feedback. 
  • Reactive oxygen species blockade and action of insulin on expression of angiotensinogen gene in proximal tubular cells. 
  • Real-time quantitative elemental analysis and mapping: microchemical imaging in cell physiology. 
  • Regulation of reconstituted renal Na+/H+ exchanger by calcium-dependent protein kinases. 
  • Regulation of the renal Na+-H+ exchanger by protein phosphorylation. 
  • Renal growth and development in mice lacking AT1A receptors for angiotensin II. 
  • Renal proximal tubule cells: power and finesse. 
  • Role of NHERF and scaffolding proteins in proximal tubule transport. 
  • Role of ubiquitin-like protein FAT10 in epithelial apoptosis in renal disease. 
  • SARS-CoV-2 causes a specific dysfunction of the kidney proximal tubule. 
  • Segmental distribution of the endocytosis receptor gp330 in renal proximal tubules. 
  • Select de novo gene and protein expression during renal epithelial cell culture in rotating wall vessels is shear stress dependent. 
  • Signaling pathways utilized by PTH and dopamine to inhibit phosphate transport in mouse renal proximal tubule cells. 
  • Sodium-hydrogen exchanger regulatory factor 1 (NHERF-1) transduces signals that mediate dopamine inhibition of sodium-phosphate co-transport in mouse kidney. 
  • Sodium-hydrogen exchanger regulatory factor-1 interacts with mouse urate transporter 1 to regulate renal proximal tubule uric acid transport. 
  • Special deLIVERy: podocyte injury promotes renal angiotensin II generation from liver-derived angiotensinogen. 
  • Spectrum and subcellular determinants of fluorinated anesthetic-mediated proximal tubular injury. 
  • Strategy for the development of a matched set of transport-competent, angiotensin receptor-deficient proximal tubule cell lines. 
  • Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia. 
  • Synergistic effect of dexamethasone and isoproterenol on the expression of angiotensinogen in immortalized rat proximal tubular cells. 
  • Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting. 
  • Targeting proximal tubule mitochondrial dysfunction attenuates the renal disease of methylmalonic acidemia. 
  • Temperature-sensitive SV40 immortalized rat proximal tubule cell line has functional renin-angiotensin system. 
  • The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins. 
  • The kidney and hypertension: novel insights from transgenic models. 
  • The role of NHERF-1 in the regulation of renal proximal tubule sodium-hydrogen exchanger 3 and sodium-dependent phosphate cotransporter 2a. 
  • Uptake of proline by brushborder vesicles isolated from human kidney cortex. 
  • Virological synapses allow HIV-1 uptake and gene expression in renal tubular epithelial cells. 
  • What's new in diuretic therapy. 
  • Will a new tenofovir prodrug for the treatment of HIV reduce the risk of nephrotoxicity? 
  • [Endocytosis and receptors: molecular and physiological aspects]. 
  • cAMP-associated inhibition of Na+-H+ exchanger in rabbit kidney brush-border membranes. 
• 

  Keywords of People

  • Preminger, Glenn Michael, James F. Glenn, M.D. Distinguished Professor of Urology, Surgery, Urology
  • Sparks, Matthew A., Associate Professor of Medicine, Medicine, Nephrology