Killer Cells, Natural

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  Subject Areas on Research

  • 2B4 utilizes ITAM-containing receptor complexes to initiate intracellular signaling and cytolysis. 
  • A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues. 
  • A critical role for type I IFN-dependent NK cell activation in innate immune elimination of adenoviral vectors in vivo. 
  • A novel approach for quantification of KIR expression in healthy donors and pediatric recipients of hematopoietic SCTs. 
  • A one-step large-scale method for T- and B-cell depletion of mobilized PBSC for allogeneic transplantation. 
  • A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone. 
  • A study of dendritic and endothelial cell interactions in colon cancer in a cell line and small mammal model. 
  • A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation. 
  • Advances in the understanding and treatment of human severe combined immunodeficiency. 
  • Alemtuzumab for the prevention and treatment of graft-versus-host disease. 
  • Alterations in antibody-dependent cellular cytotoxicity during the course of HIV-1 infection. Humoral and cellular defects. 
  • Analysis of the immune responses in chimpanzees infected with HIV type 1 isolates. 
  • Analysis of the linker for activation of T cells and the linker for activation of B cells in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire. 
  • Analysis of the relationship between stage of differentiation and NK/LAK susceptibility of colon carcinoma cells. 
  • Anti-HIV-1 ADCC: clinical and therapeutic implications. 
  • Anti-glycoprotein D monoclonal antibody protects against herpes simplex virus type 1-induced diseases in mice functionally depleted of selected T-cell subsets or asialo GM1+ cells. 
  • Anti-self HLA may be clonally expressed. 
  • Antibody-dependent cell-mediated cytotoxicity in simian immunodeficiency virus-infected rhesus monkeys. 
  • Are the salutogenic effects of social supports modified by income? A test of an "added value hypothesis". 
  • Autologous lymph node cell-derived tumor-specific cytotoxic T-cells for use in adoptive immunotherapy of human melanoma. 
  • Both NK cell-intrinsic and -extrinsic STAT1 signaling are required for NK cell response against vaccinia virus. 
  • Breast cancer patients have improved immune and neuroendocrine functions following massage therapy. 
  • CALGB 150905 (Alliance): rituximab broadens the antilymphoma response by activating unlicensed NK cells. 
  • CD3 delta and epsilon gene expression in CD3-CD16+ natural killer cell clones derived from thymic precursors. 
  • CD8(+)NKR-P1A (+)T cells preferentially accumulate in human liver. 
  • Cellular anti-GP120 cytolytic reactivities in HIV-1 seropositive individuals. 
  • Characterization of cord blood natural killer and lymphokine activated killer lymphocytes following ex vivo cellular engineering. 
  • Characterization of cytotoxic cells generated from in vitro cultures of murine bone marrow cells. 
  • Circulating T-Cell Subsets, Monocytes, and Natural Killer Cells in Peripartum Cardiomyopathy: Results From the Multicenter IPAC Study. 
  • Circulating natural killer cell phenotypes in men and women with major depression. Relation to cytotoxic activity and severity of depression. 
  • Clinical and immunologic effects of prolonged infusion of low-dose recombinant interleukin-2 after autologous and T-cell-depleted allogeneic bone marrow transplantation. 
  • Clinical application of whole-genome sequencing in patients with primary immunodeficiency. 
  • Cloning of a novel cell type from human fetal liver expressing cytoplasmic CD3 delta and epsilon but not membrane CD3. 
  • Cloning of murine splenic T lymphocytes and natural killer (NK) cells on filter paper discs: detection of a novel NK/T phenotype. 
  • Combination treatment of murine tumors by adenovirus-mediated local B7/IL12 immunotherapy and radiotherapy. 
  • Contrasting effects of centromedial and basolateral amygdaloid lesions on stress-related responses in the rat. 
  • Copy number variation of KIR genes influences HIV-1 control. 
  • Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model. 
  • Costimulation, coinhibition and cancer. 
  • Costimulatory molecules are active in the human xenoreactive T-cell response but not in natural killer-mediated cytotoxicity. 
  • Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. 
  • Cutting edge: a role for the adaptor protein LAT in human NK cell-mediated cytotoxicity. 
  • Cytokine augmentation of human immunodeficiency virus type 1 (HIV-1) gp120-specific cellular cytotoxicity. 
  • Decreased normal NK-cells is a characteristic of T-cell large granular lymphocytic leukemia and is strongly associated with cytopenia. 
  • Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency. 
  • Definition of a novel cellular constituent of the bone marrow that regulates the response of immature B cells to B cell antigen receptor engagement. 
  • Dendritic cell responses to early murine cytomegalovirus infection: subset functional specialization and differential regulation by interferon alpha/beta. 
  • Dendritic cells/natural killer cross-talk: a novel target for human immunodeficiency virus type-1 protease inhibitors. 
  • Determination of CD4 and CD8 lymphocyte subsets by a new alternative fluorescence immunoassay. 
  • Development and distribution of a human B cell subpopulation identified by the HB-4 monoclonal antibody. 
  • Development of immunity in human severe primary T cell deficiency following haploidentical bone marrow stem cell transplantation. 
  • Differential requirement for the SAP-Fyn interaction during NK T cell development and function. 
  • Direct TLR2 signaling is critical for NK cell activation and function in response to vaccinia viral infection. 
  • Direct action of type I IFN on NK cells is required for their activation in response to vaccinia viral infection in vivo. 
  • Distinct hematopoietic progenitor compartments are delineated by the expression of aldehyde dehydrogenase and CD34. 
  • Donor type natural killer cells after haploidentical T cell-depleted bone marrow stem cell transplantation in a patient with adenosine deaminase-deficient severe combined immunodeficiency. 
  • EL-4 metastases in spleen and bone marrow suppress the NK activity generated in these organs. 
  • Early-onset monocyte-B-natural killer-dendritic cells' deficiency successfully treated with hematopoietic stem cell transplantation. 
  • Effect of high doses of intravenously administered immune globulin on natural killer cell activity in peripheral blood. 
  • Effector mechanisms in transplant rejection. 
  • Effects of one year of supplementation with zinc and other micronutrients on cellular immunity in the elderly. 
  • Effects of pretransplant splenectomy and immunosuppression of humoral immunity in a pig-to-newborn goat cardiac xenograft model. 
  • Elevated serum L-selectin levels and abnormal regulation of L-selectin expression on leukocytes in atopic dermatitis: soluble L-selectin levels indicate disease severity. 
  • Endoplasmic reticulum stress, hepatocyte CD1d and NKT cell abnormalities in murine fatty livers. 
  • Epstein-Barr virus-associated posttransplantation lymphoproliferative disorder after high-dose immunosuppressive therapy and autologous CD34-selected hematopoietic stem cell transplantation for severe autoimmune diseases. 
  • Essential role of LAT in T cell development. 
  • Ex vivo expanded human CD4+ regulatory NKT cells suppress expansion of tumor antigen-specific CTLs. 
  • Ex vivo spermine dialdehyde treatment prevents lethal GVHD in a murine bone marrow transplantation model. 
  • Expansions of NK-like αβT cells with chronologic aging: novel lymphocyte effectors that compensate for functional deficits of conventional NK cells and T cells. 
  • Expression of C3b receptors on human be cells and myelomonocytic cells but not natural killer cells. 
  • Expression, distribution, and biochemistry of human CD39. Role in activation-associated homotypic adhesion of lymphocytes. 
  • Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif. 
  • GP120 specific cellular cytotoxicity in HIV-1 seropositive individuals. Evidence for circulating CD16+ effector cells armed in vivo with cytophilic antibody. 
  • GRP94 (gp96) and GRP94 N-terminal geldanamycin binding domain elicit tissue nonrestricted tumor suppression. 
  • Gaining insights into chronic natural killer cell leukemias through extensive characterization of an individual case. 
  • Gene therapy for human SCID: dreams become reality. 
  • Glucose-regulated protein 94/glycoprotein 96 elicits bystander activation of CD4+ T cell Th1 cytokine production in vivo. 
  • Granulocyte-macrophage colony-stimulating factor and interleukin-3 mRNAs are produced by a small fraction of blood mononuclear cells. 
  • Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis. 
  • HLA-C and liver transplant outcomes: interpreting the facts. 
  • Hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency. 
  • Heparan sulfate mimetic PG545-mediated antilymphoma effects require TLR9-dependent NK cell activation. 
  • Hepatosplenic T-Cell Lymphoma: A Clinicopathologic Review With an Emphasis on Diagnostic Differentiation From Other T-Cell/Natural Killer-Cell Neoplasms. 
  • High versus low basal cortisol secretion in asymptomatic, medication-free HIV-infected men: differential effects of severe life stress on parameters of immune status. 
  • High-dose human lymphoblastoid interferon in metastatic colorectal cancer: clinical results and modification of biological responses. 
  • High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses. 
  • Human cytotoxic T cells specific for autologous melanoma cells: successful generation from lymph node cells in seven consecutive cases. 
  • Human natural killer cells analyzed by B73.1, a monoclonal antibody blocking Fc receptor functions. I. Characterization of the lymphocyte subset reactive with B73.1. 
  • Human natural killer cells do not inhibit growth of Cryptococcus neoformans in the absence of antibody. 
  • Human placental cytotrophoblasts attract monocytes and CD56(bright) natural killer cells via the actions of monocyte inflammatory protein 1alpha. 
  • Hyperinflammation, T cells, and endotoxemia. 
  • IL-10 stimulatory effects on human NK cells explored by gene profile analysis. 
  • IL-18-dependent NKG2D ligand upregulation on accessory cells is mediated by the PI3K/GSK-3 pathway. 
  • Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans. 
  • IgE Fc receptor positive T, B and NK cells in patients with the hyper-IgE syndrome. 
  • Immune surveillance by mast cells during dengue infection promotes natural killer (NK) and NKT-cell recruitment and viral clearance. 
  • Immunity of patients surviving 20 to 30 years after allogeneic or syngeneic bone marrow transplantation. 
  • Immunogenic determinants of a neuropathogenic murine leukemia virus. 
  • Immunologic control of a retrovirus-associated murine adenocarcinoma. VIII. Corynebacterium parvum-activated natural killer cells as potent antibody-dependent cell-mediated cytotoxicity effectors. 
  • Immunology. Outwitted by viral RNAs. 
  • Immunotherapy Gone Viral: Bortezomib and oHSV Enhance Antitumor NK-Cell Activity. 
  • Immunotherapy of B-cell malignancies with genetically engineered human CD8+ natural killer T cells. 
  • Immunotherapy of patients with advanced cancer using tumor-infiltrating lymphocytes and recombinant interleukin-2: a pilot study. 
  • Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections. 
  • Inhibition of human natural killer cell activity by a synthetic peptide homologous to a conserved region in the retroviral protein, p15E. 
  • Innate activation of MDC and NK cells in high-risk HIV-1-exposed seronegative IV-drug users who share needles when compared with low-risk nonsharing IV-drug user controls. 
  • Interferon-γ-secreting NK cells promote induction of dry eye disease. 
  • Interleukin-15 enhances the secretion of IFN-gamma and CC chemokines by natural killer cells from HIV viremic and aviremic patients. 
  • Interleukin-15 receptor blockade in non-human primate kidney transplantation. 
  • Interleukin-15-Stimulated Natural Killer Cells Clear HIV-1-Infected Cells following Latency Reversal Ex Vivo. 
  • Interleukin-2 immunotherapy of murine cytomegalovirus retinitis during MAIDS correlates with increased intraocular CD8+ T-cell infiltration. 
  • Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells. 
  • Intrathecal morphine suppresses immune function in rats with inflammatory-induced pain. 
  • Involvement of histo-blood-group antigens in the susceptibility of colon carcinoma cells to natural killer-mediated cytotoxicity. 
  • Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation. 
  • Lack of generation of killer cells in the mixed lymphocyte reaction between mitogen-stimulated and unstimulated autologous lymphocytes. 
  • Ligand-independent toll-like receptor signals generated by ectopic overexpression of MyD88 generate local and systemic antitumor immunity. 
  • Linker for activation of T cells (LAT), a novel immunohistochemical marker for T cells, NK cells, mast cells, and megakaryocytes: evaluation in normal and pathological conditions. 
  • Long-term effects of intermittent interleukin 2 therapy in patients with HIV infection: characterization of a novel subset of CD4(+)/CD25(+) T cells. 
  • Long-term efficacy of enzyme replacement therapy for adenosine deaminase (ADA)-deficient severe combined immunodeficiency (SCID). 
  • Long-term killing of natural killer-resistant target cells by interferon-alpha-, interferon-gamma-, and interleukin-2-activated natural killer cells. 
  • Longitudinal peripheral blood lymphocyte subsets correlate with decreased disease activity in juvenile dermatomyositis. 
  • Loss of tumorigenicity following in vitro MuLV infection is associated with induction of peritoneal natural killer cell activity. 
  • Lymphocyte abnormalities in preleukemia--I. Decreased NK activity, anomalous immunoregulatory cell subsets and deficient EBV receptors. 
  • Lymphocyte and monocyte subset changes during cardiopulmonary bypass: effects of aging and gender. 
  • Lymphocyte subsets in Chediak-Higashi patients. 
  • Measurement of direct and indirect forms of anti-HIV-1 ADCC: implications for other retroviral disease. 
  • Mechanism of the anti-tumour effect of biochemotherapy in melanoma: preliminary results. 
  • Monoclonal Antibodies, Derived from Humans Vaccinated with the RV144 HIV Vaccine Containing the HVEM Binding Domain of Herpes Simplex Virus (HSV) Glycoprotein D, Neutralize HSV Infection, Mediate Antibody-Dependent Cellular Cytotoxicity, and Protect Mice from Ocular Challenge with HSV-1. 
  • Monocytic myeloid-derived suppressor cells regulate T-cell responses against vaccinia virus. 
  • Multiple constraints at the level of TCRalpha rearrangement impact Valpha14i NKT cell development. 
  • Murine in vitro antigenic modification of tumor cells: effect on susceptibility to natural cell-mediated cytotoxicity. 
  • Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function. 
  • Myeloid-derived suppressor cells regulate natural killer cell response to adenovirus-mediated gene transfer. 
  • NK and LAK susceptibility varies inversely with target cell MHC class I antigen expression in a rat epithelial tumour system. 
  • NK cell activation by dendritic cell vaccine: a mechanism of action for clinical activity. 
  • NK cell response to vaccinia virus is regulated by myeloid-derived suppressor cells. 
  • NK cell-extrinsic IL-18 signaling is required for efficient NK-cell activation by vaccinia virus. 
  • NK susceptibility varies inversely with target cell class I HLA antigen expression. 
  • NKG2D is required for NK cell activation and function in response to E1-deleted adenovirus. 
  • NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway. 
  • NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells. 
  • Natural killer cell infection and inactivation in vitro by the human immunodeficiency virus. 
  • Natural killer cell responses to viral infection. 
  • Natural killer cell-endothelial cell interactions in xenotransplantation. 
  • Natural killer cell-enriched donor lymphocyte infusions from A 3-6/6 HLA matched family member following nonmyeloablative allogeneic stem cell transplantation. 
  • Natural killer cells in vernal keratoconjunctivitis. 
  • Natural killing in immunodeficient patients. 
  • Natural killing target antigens as inducers of interferon: studies with an immunoselected, natural killing-resistant human T lymphoblastoid cell line. 
  • Natural-killer-cell function and bone marrow transplantation. 
  • Nociceptive neurons regulate innate and adaptive immunity and neuropathic pain through MyD88 adapter. 
  • Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis. 
  • Novel mechanisms of immune modulation of natalizumab in multiple sclerosis patients. 
  • Optimization of vaccine responses with an E1, E2b and E3-deleted Ad5 vector circumvents pre-existing anti-vector immunity. 
  • Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells. 
  • Osteopontin has a protective role in prostate tumor development in mice. 
  • Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge. 
  • Peripheral blood dendritic cells, but not monocyte-derived dendritic cells, can augment human NK cell function. 
  • Phase I studies of interleukin (IL)-2 and rituximab in B-cell non-hodgkin's lymphoma: IL-2 mediated natural killer cell expansion correlations with clinical response. 
  • Phase I study of pharmacological and immunological effects of human lymphoblastoid interferon given to patients with cancer. 
  • Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes. 
  • Postremission therapy with low-dose interleukin 2 with or without intermediate pulse dose interleukin 2 therapy is well tolerated in elderly patients with acute myeloid leukemia: Cancer and Leukemia Group B study 9420. 
  • Potent functional antibody responses elicited by HIV-I DNA priming and boosting with heterologous HIV-1 recombinant MVA in healthy Tanzanian adults. 
  • Preoperative mobilization of circulating dendritic cells by Flt3 ligand administration to patients with metastatic colon cancer. 
  • Preservation of motor function by inhibition of CD8+ virus peptide-specific T cells in Theiler's virus infection. 
  • Primate renal transplants using immunotoxin. 
  • Prolonged discordant xenograft survival and delayed xenograft rejection in a pig-to-baboon orthotopic cardiac xenograft model. 
  • Prospects for treatment of human retrovirus-associated diseases. 
  • Psychosocial stress moderates the relationship of cancer history with natural killer cell activity. 
  • Radiation and a metalloporphyrin radioprotectant in a mouse prostate tumor model. 
  • Rapid immune reconstitution after a reduced-intensity conditioning regimen and a CD3-depleted haploidentical stem cell graft for paediatric refractory haematological malignancies. 
  • Regulation of local and metastatic host-mediated anti-tumour mechanisms by L-selectin and intercellular adhesion molecule-1. 
  • Relationship between sensitivity to natural killer cells and MHC class-I antigen expression in colon carcinoma cell lines. 
  • Role of natural killer cell function in dendritic cell-based vaccines. 
  • Selective inhibition of natural killer activity by the monoclonal antibodies OKT10 and VEP10 at the single cell level. 
  • Selective modulation of human natural killer cells in vivo after prolonged infusion of low dose recombinant interleukin 2. 
  • Self-discrepancy and natural killer cell activity: immunological consequences of negative self-evaluation. 
  • Self-regulatory cognition and immune reactivity: idiographic success and failure feedback effects on the natural killer cell. 
  • Serum concentrations of soluble human leukocyte class I antigens and of the soluble intercellular adhesion molecule-1 in endometriosis: relationship with stage and non-pigmented peritoneal lesions. 
  • Severe combined immunodeficiency (SCID) with natural killer (NK) cell predominance. 
  • Severe combined immunodeficiency with natural killer-cell predominance: abrogation of graft-versus-host disease and immunologic reconstitution with HLA-identical bone marrow cells. 
  • Study of the role of CCR5 in a mouse model of intranasal challenge with Yersinia pestis. 
  • Subcutaneous vaccination with irradiated, cytokine-producing tumor cells stimulates CD8+ cell-mediated immunity against tumors located in the "immunologically privileged" central nervous system. 
  • Synergy of adoptive T-cell therapy and intratumoral suicide gene therapy is mediated by host NK cells. 
  • T cell-mediated elimination of B7.2 transgenic B cells. 
  • T lymphocyte ontogeny in adenosine deaminase-deficient severe combined immune deficiency after treatment with polyethylene glycol-modified adenosine deaminase. 
  • T-B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3zeta subunit of the T-cell antigen receptor complex. 
  • The dual role of IL-10. 
  • The effect of AZT on in vitro lymphokine-activated killer (LAK) activity in human immunodeficiency virus type-1 (HIV-1) infected individuals. 
  • The effect of natural killer cell killer Ig-like receptor alloreactivity on the outcome of bone marrow stem cell transplantation for severe combined immunodeficiency (SCID). 
  • The effects of donor-specific blood transfusion enhancement of rat renal allografts on cytotoxic activity and phenotypes of peripheral blood lymphocytes, splenocytes, and graft-infiltrating cells. 
  • The effects of donor-specific blood transfusion enhancement of rat renal allografts on host NK cell responses. 
  • The host defense peptide cathelicidin is required for NK cell-mediated suppression of tumor growth. 
  • The immune system in aging: roles of cytokines, T cells and NK cells. 
  • The impact of HIV-1 infection on phenotypic and functional parameters of cellular immunity in chimpanzees. 
  • The isoforms of phospholipase C-gamma are differentially used by distinct human NK activating receptors. 
  • The role of natural killer (NK) cells and NK cell receptor polymorphisms in the assessment of HIV-1 neutralization. 
  • The use of enzyme therapy to regulate the metabolic and phenotypic consequences of adenosine deaminase deficiency in mice. Differential impact on pulmonary and immunologic abnormalities. 
  • Thy1+ NK [corrected] cells from vaccinia virus-primed mice confer protection against vaccinia virus challenge in the absence of adaptive lymphocytes. 
  • Thymoma-associated immunodeficiency: a syndrome characterized by severe alterations in NK, T and B-cells and progressive increase in naïve CD8+ T Cells. 
  • Tracking KLRC2 (NKG2C)+ memory-like NK cells in SIV+ and rhCMV+ rhesus macaques. 
  • Transcriptional regulation of T lymphocyte development and function. 
  • Transduction of human melanoma cells with the gamma interferon gene enhances cellular immunity. 
  • Tumor necrosis factor, natural killer activity and other measures of immune function and inflammation in elderly men with heart failure. 
  • Viral and bacterial infections induce expression of multiple NK cell receptors in responding CD8(+) T cells. 
  • Why newborn screening for severe combined immunodeficiency is essential: a case report. 
  • X-linked inhibitor of apoptosis protein mediates tumor cell resistance to antibody-dependent cellular cytotoxicity. 
  • X-linked lymphoproliferative disease (XLP): a model of impaired anti-viral, anti-tumor and humoral immune responses. 
  • [Effect of intrathecal pumping morphine on immunological function in rats with formalin pain]. 
  • [Effect of intrathecal pumping tramadol on the immune function in rats with formalin pain]. 
  • mTORC2 in Thymic Epithelial Cells Controls Thymopoiesis and T Cell Development. 
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  Keywords of People

  • Buckley, Rebecca Hatcher, James Buren Sidbury Professor of Pediatrics, in the School of Medicine, Immunology
  • Ferrari, Guido, Associate Professor of Surgery, Molecular Genetics and Microbiology
  • Krangel, Michael S., Mary Bernheim Professor of Immunology, Immunology
  • Shinohara, Mari L., Associate Professor of Immunology, Immunology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Professor of Experimental Surgery, in the School of Medicine, Immunology
  • Yang, Yiping, Professor of Medicine, Immunology
  • Zhong, Xiaoping, Professor of Pediatrics, Immunology