Kindling, Neurologic

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  Subject Areas on Research

  • A point mutation (D79N) of the alpha2A adrenergic receptor abolishes the antiepileptogenic action of endogenous norepinephrine. 
  • Abnormal hyperexcitability of hippocampal slices from kindled rats is transient. 
  • Abnormal neuronal excitability in hippocampal slices from kindled rats. 
  • Activation of substantia nigra neurons: role in the propagation of seizures in kindled rats. 
  • Activation of substantia nigra pars reticulata neurons: role in the initiation and behavioral expression of kindled seizures. 
  • Activity of locus coeruleus neurons in amygdala kindled rats: role in the suppression of afterdischarge. 
  • Alpha-2 receptors mediate an endogenous noradrenergic suppression of kindling development. 
  • An examination of the proconvulsant actions of pyrethroid insecticides using pentylenetetrazol and amygdala kindling seizure models. 
  • An in vitro autoradiographic analysis of mu and delta opioid binding in the hippocampal formation of kindled rats. 
  • Analyses of the molecular basis of kindling development. 
  • Anti-seizure and anti-epileptogenic effect of gamma-vinyl gamma-aminobutyric acid in amygdaloid kindling. 
  • Anticonvulsant and antiepileptogenic actions of MK-801 in the kindling and electroshock models. 
  • Antiepileptic effects of GABAb receptor activation in area CA3 of rat hippocampus. 
  • Antiepileptogenic effects of conventional anticonvulsants in the kindling model of epilespy. 
  • Attenuation of epileptogenesis: proactive effect of a single epinephrine injection of amygdaloid kindling. 
  • Axon terminal hyperexcitability associated with epileptogenesis in vitro. I. Origin of ectopic spikes. 
  • Axon terminal hyperexcitability associated with epileptogenesis in vitro. II. Pharmacological regulation by NMDA and GABAA receptors. 
  • Biochemical and radiohistochemical analyses of alpha-2 adrenergic receptors in the kindling model of epilepsy. 
  • Biochemical evidence for enhanced sensitivity to N-methyl-D-aspartate in the hippocampal formation of kindled rats. 
  • Changes in dynorphin, enkephalin and cholecystokinin content of hippocampus and substantia nigra after amygdala kindling. 
  • Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling model. 
  • Conditional deletion of TrkC does not modify limbic epileptogenesis. 
  • Convulsant properties of cyclotrimethylenetrinitramine (RDX): spontaneous audiogenic, and amygdaloid kindled seizure activity. 
  • Development of new pharmacological agents for epilepsy: lessons from the kindling model. 
  • Differences in the anatomic distribution of immediate-early gene expression in amygdala and angular bundle kindling development. 
  • Differential expression of immediate early genes in the hippocampus in the kindling model of epilepsy. 
  • Disruption of TrkB-mediated phospholipase Cgamma signaling inhibits limbic epileptogenesis. 
  • Effect of kindling on potassium-induced electrographic seizures in vitro. 
  • Effects of age on kindling and kindled seizure-induced increase of benzodiazepine receptor binding. 
  • Effects of kindling on subsequent learning, memory, behavior, and seizure susceptibility. 
  • Effects of single and repeated alcohol withdrawal on kindling. 
  • Epinephrine proactive retardation of amygdala-kindled epileptogenesis. 
  • Evidence implicating alpha-2 adrenergic receptors in the anticonvulsant action of intranigral muscimol. 
  • Evidence implicating dentate granule cells in development of entorhinal kindling. 
  • Evidence implicating dentate granule cells in wet dog shakes produced by kindling stimulations of entorhinal cortex. 
  • Evidence implicating substantia nigra in regulation of kindled seizure threshold. 
  • Evidence that Substantia Nigra is crucial to neural network of kindled seizures. 
  • Excitatory amino acid receptors and epilepsy. 
  • Experimental partial epileptogenesis. 
  • Facilitation of cocaine kindling by glucocorticoids in rats. 
  • Focal electrically administered seizure therapy: a novel form of ECT illustrates the roles of current directionality, polarity, and electrode configuration in seizure induction. 
  • GABA receptor function and epilepsy. 
  • Immunohistochemical evidence of seizure-induced activation of trk receptors in the mossy fiber pathway of adult rat hippocampus. 
  • Immunohistochemical evidence of seizure-induced activation of trkB receptors in the mossy fiber pathway of adult mouse hippocampus. 
  • Impairment of kindling development in phospholipase Cγ1 heterozygous mice. 
  • Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. 
  • Increased dentate granule cell neurogenesis following amygdala kindling in the adult rat. 
  • Induction of c-fos mRNA by kindled seizures: complex relationship with neuronal burst firing. 
  • Induction of c-fos mRNA expression by afterdischarge in the hippocampus of naive and kindled rats. 
  • Induction of epileptiform activity in hippocampal slices by trains of electrical stimuli. 
  • Inhibiting glycolysis to reduce seizures: how it might work. 
  • Intradentate colchicine retards the development of amygdala kindling. 
  • Intranigral dynorphin-1-13 suppresses kindled seizures by a naloxone-insensitive mechanism. 
  • Intravenous phenytoin is an effective anticonvulsant in the kindling model. 
  • Kainate and quisqualate receptor autoradiography in rat brain after angular bundle kindling. 
  • Kindled seizure-induced reduction of muscarinic cholinergic receptors in rat hippocampal formation: evidence for localization to dentate granule cells. 
  • Kindled seizures result in decreased responsiveness of benzodiazepine receptors to gamma-aminobutyric acid (GABA). 
  • Kindled seizures selectively reduce a subpopulation of [3H]quinuclidinyl benzilate binding sites in rat dentate gyrus. 
  • Kindling and associated mossy fibre sprouting are not affected in mice deficient of NGFI-A/NGFI-B genes. 
  • Kindling enhances sensitivity of CA3 hippocampal pyramidal cells to NMDA. 
  • Kindling induces the long-lasting expression of a novel population of NMDA receptors in hippocampal region CA3. 
  • Kindling model of epilepsy. 
  • Kindling produces long-lasting and selective changes in gene expression of hippocampal neurons. 
  • Kindling reduces sensitivity of CA3 hippocampal pyramidal cells to competitive NMDA receptor antagonists. 
  • Kindling, prenatal exposure to ethanol and postnatal development selectively alter responses of hippocampal pyramidal cells to NMDA. 
  • Kindling: an animal model of complex partial epilepsy. 
  • Knife cuts of entorhinal cortex: effects on development of amygdaloid kindling and seizure-induced decrease of muscarinic cholinergic receptors. 
  • Knock-in mouse model of alternating hemiplegia of childhood: behavioral and electrophysiologic characterization. 
  • Lateral entorhinal cortical kindling can be established without potentiation of the entorhinal-granule cell synapse. 
  • Measurement of NMDA receptor protein subunits in discrete hippocampal regions of kindled animals. 
  • Microinjection of a benzodiazepine into substantia nigra elevates kindled seizure threshold. 
  • Morphological changes among hippocampal dentate granule cells exposed to early kindling-epileptogenesis. 
  • N-methyl-D-aspartate receptor autoradiography in rat brain after angular bundle kindling. 
  • N-methyl-D-aspartate receptor plasticity in kindling: quantitative and qualitative alterations in the N-methyl-D-aspartate receptor-channel complex. 
  • NMDA receptor dependence of kindling and mossy fiber sprouting: evidence that the NMDA receptor regulates patterning of hippocampal circuits in the adult brain. 
  • NMDA receptor plasticity in the kindling model. 
  • Null mutation of c-fos impairs structural and functional plasticities in the kindling model of epilepsy. 
  • Pursuit of the mechanisms of kindling. 
  • Recent advances in understanding mechanisms of the kindling model. 
  • Reduced kainic acid binding in rat hippocampal formation after limbic kindling. 
  • Reduction of TrkB expression de novo in the adult mouse impairs epileptogenesis in the kindling model. 
  • Regulation of alternative splicing of NMDAR1 in the kindling model. 
  • Role of neurotransmitters in seizure mechanisms in the kindling model of epilepsy. 
  • Role of the substantia nigra in the kindling model of limbic epilepsy. 
  • Seizure predisposition after perinatal hypoxia: effects of subsequent age and of an epilepsy predisposing gene mutation. 
  • Seizures down-regulate muscarinic cholinergic receptors in hippocampal formation. 
  • Selective and reversible increase in the number of quisqualate-sensitive glutamate binding sites on hippocampal synaptic membranes after angular bundle kindling. 
  • Selective increase in L-[3H]glutamate binding to a quisqualate-sensitive site on hippocampal synaptic membranes after angular bundle kindling. 
  • Selective inhibition of kindling development by intraventricular administration of TrkB receptor body. 
  • Sustained potential shifts and paroxysmal discharges in hippocampal formation. 
  • TCP binding: a tool for studying NMDA receptor-mediated neurotransmission in kindling. 
  • The auxiliary subunit KChIP2 is an essential regulator of homeostatic excitability. 
  • The genesis of seizures in vitro: axon terminal excitability. 
  • The kindling model of epilepsy: a critical review. 
  • The role of NMDA receptors in in vitro epileptogenesis. 
  • The role of substantia nigra in the development of kindling: pharmacologic and lesion studies. 
  • The tyrosine receptor kinase B ligand, neurotrophin-4, is not required for either epileptogenesis or tyrosine receptor kinase B activation in the kindling model. 
  • Unilateral kindling of the inferior collicular cortex does not transfer to the contralateral seizure sensitive site or alter [3H]flunitrazepam and [35S]TBPS binding. 
  • Vagus nerve stimulation elevates seizure threshold in the kindling model. 
  • gamma-Aminobutyric acid and benzodiazepine receptors in the kindling model of epilepsy: a quantitative radiohistochemical study. 
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  Keywords of People

  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology