Kindling, Neurologic
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Subject Areas on Research
- A point mutation (D79N) of the alpha2A adrenergic receptor abolishes the antiepileptogenic action of endogenous norepinephrine.
- Abnormal hyperexcitability of hippocampal slices from kindled rats is transient.
- Abnormal neuronal excitability in hippocampal slices from kindled rats.
- Activation of substantia nigra neurons: role in the propagation of seizures in kindled rats.
- Activation of substantia nigra pars reticulata neurons: role in the initiation and behavioral expression of kindled seizures.
- Activity of locus coeruleus neurons in amygdala kindled rats: role in the suppression of afterdischarge.
- Alpha-2 receptors mediate an endogenous noradrenergic suppression of kindling development.
- An examination of the proconvulsant actions of pyrethroid insecticides using pentylenetetrazol and amygdala kindling seizure models.
- An in vitro autoradiographic analysis of mu and delta opioid binding in the hippocampal formation of kindled rats.
- Analyses of the molecular basis of kindling development.
- Anti-seizure and anti-epileptogenic effect of gamma-vinyl gamma-aminobutyric acid in amygdaloid kindling.
- Anticonvulsant and antiepileptogenic actions of MK-801 in the kindling and electroshock models.
- Antiepileptic effects of GABAb receptor activation in area CA3 of rat hippocampus.
- Antiepileptogenic effects of conventional anticonvulsants in the kindling model of epilespy.
- Attenuation of epileptogenesis: proactive effect of a single epinephrine injection of amygdaloid kindling.
- Axon terminal hyperexcitability associated with epileptogenesis in vitro. I. Origin of ectopic spikes.
- Axon terminal hyperexcitability associated with epileptogenesis in vitro. II. Pharmacological regulation by NMDA and GABAA receptors.
- Biochemical and radiohistochemical analyses of alpha-2 adrenergic receptors in the kindling model of epilepsy.
- Biochemical evidence for enhanced sensitivity to N-methyl-D-aspartate in the hippocampal formation of kindled rats.
- Changes in dynorphin, enkephalin and cholecystokinin content of hippocampus and substantia nigra after amygdala kindling.
- Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling model.
- Conditional deletion of TrkC does not modify limbic epileptogenesis.
- Development of new pharmacological agents for epilepsy: lessons from the kindling model.
- Differences in the anatomic distribution of immediate-early gene expression in amygdala and angular bundle kindling development.
- Differential expression of immediate early genes in the hippocampus in the kindling model of epilepsy.
- Disruption of TrkB-mediated phospholipase Cgamma signaling inhibits limbic epileptogenesis.
- Effect of kindling on potassium-induced electrographic seizures in vitro.
- Effects of age on kindling and kindled seizure-induced increase of benzodiazepine receptor binding.
- Effects of kindling on subsequent learning, memory, behavior, and seizure susceptibility.
- Effects of single and repeated alcohol withdrawal on kindling.
- Epinephrine proactive retardation of amygdala-kindled epileptogenesis.
- Evidence implicating alpha-2 adrenergic receptors in the anticonvulsant action of intranigral muscimol.
- Evidence implicating dentate granule cells in development of entorhinal kindling.
- Evidence implicating dentate granule cells in wet dog shakes produced by kindling stimulations of entorhinal cortex.
- Evidence implicating substantia nigra in regulation of kindled seizure threshold.
- Evidence that Substantia Nigra is crucial to neural network of kindled seizures.
- Excitatory amino acid receptors and epilepsy.
- Experimental partial epileptogenesis.
- Facilitation of cocaine kindling by glucocorticoids in rats.
- Focal electrically administered seizure therapy: a novel form of ECT illustrates the roles of current directionality, polarity, and electrode configuration in seizure induction.
- Immunohistochemical evidence of seizure-induced activation of trk receptors in the mossy fiber pathway of adult rat hippocampus.
- Immunohistochemical evidence of seizure-induced activation of trkB receptors in the mossy fiber pathway of adult mouse hippocampus.
- Impairment of kindling development in phospholipase Cγ1 heterozygous mice.
- Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo.
- Increased dentate granule cell neurogenesis following amygdala kindling in the adult rat.
- Induction of c-fos mRNA by kindled seizures: complex relationship with neuronal burst firing.
- Induction of c-fos mRNA expression by afterdischarge in the hippocampus of naive and kindled rats.
- Induction of epileptiform activity in hippocampal slices by trains of electrical stimuli.
- Inhibiting glycolysis to reduce seizures: how it might work.
- Intradentate colchicine retards the development of amygdala kindling.
- Intranigral dynorphin-1-13 suppresses kindled seizures by a naloxone-insensitive mechanism.
- Intravenous phenytoin is an effective anticonvulsant in the kindling model.
- Kainate and quisqualate receptor autoradiography in rat brain after angular bundle kindling.
- Kindled seizure-induced reduction of muscarinic cholinergic receptors in rat hippocampal formation: evidence for localization to dentate granule cells.
- Kindled seizures result in decreased responsiveness of benzodiazepine receptors to gamma-aminobutyric acid (GABA).
- Kindled seizures selectively reduce a subpopulation of [3H]quinuclidinyl benzilate binding sites in rat dentate gyrus.
- Kindling and associated mossy fibre sprouting are not affected in mice deficient of NGFI-A/NGFI-B genes.
- Kindling enhances sensitivity of CA3 hippocampal pyramidal cells to NMDA.
- Kindling induces the long-lasting expression of a novel population of NMDA receptors in hippocampal region CA3.
- Kindling model of epilepsy.
- Kindling produces long-lasting and selective changes in gene expression of hippocampal neurons.
- Kindling reduces sensitivity of CA3 hippocampal pyramidal cells to competitive NMDA receptor antagonists.
- Kindling, prenatal exposure to ethanol and postnatal development selectively alter responses of hippocampal pyramidal cells to NMDA.
- Kindling: an animal model of complex partial epilepsy.
- Knife cuts of entorhinal cortex: effects on development of amygdaloid kindling and seizure-induced decrease of muscarinic cholinergic receptors.
- Knock-in mouse model of alternating hemiplegia of childhood: behavioral and electrophysiologic characterization.
- Lateral entorhinal cortical kindling can be established without potentiation of the entorhinal-granule cell synapse.
- Measurement of NMDA receptor protein subunits in discrete hippocampal regions of kindled animals.
- Microinjection of a benzodiazepine into substantia nigra elevates kindled seizure threshold.
- Morphological changes among hippocampal dentate granule cells exposed to early kindling-epileptogenesis.
- N-methyl-D-aspartate receptor autoradiography in rat brain after angular bundle kindling.
- N-methyl-D-aspartate receptor plasticity in kindling: quantitative and qualitative alterations in the N-methyl-D-aspartate receptor-channel complex.
- NMDA receptor dependence of kindling and mossy fiber sprouting: evidence that the NMDA receptor regulates patterning of hippocampal circuits in the adult brain.
- NMDA receptor plasticity in the kindling model.
- Null mutation of c-fos impairs structural and functional plasticities in the kindling model of epilepsy.
- Pursuit of the mechanisms of kindling.
- Recent advances in understanding mechanisms of the kindling model.
- Reduced kainic acid binding in rat hippocampal formation after limbic kindling.
- Reduction of TrkB expression de novo in the adult mouse impairs epileptogenesis in the kindling model.
- Regulation of alternative splicing of NMDAR1 in the kindling model.
- Role of neurotransmitters in seizure mechanisms in the kindling model of epilepsy.
- Role of the substantia nigra in the kindling model of limbic epilepsy.
- Seizure predisposition after perinatal hypoxia: effects of subsequent age and of an epilepsy predisposing gene mutation.
- Seizures down-regulate muscarinic cholinergic receptors in hippocampal formation.
- Selective and reversible increase in the number of quisqualate-sensitive glutamate binding sites on hippocampal synaptic membranes after angular bundle kindling.
- Selective increase in L-[3H]glutamate binding to a quisqualate-sensitive site on hippocampal synaptic membranes after angular bundle kindling.
- Selective inhibition of kindling development by intraventricular administration of TrkB receptor body.
- Sustained potential shifts and paroxysmal discharges in hippocampal formation.
- TCP binding: a tool for studying NMDA receptor-mediated neurotransmission in kindling.
- The auxiliary subunit KChIP2 is an essential regulator of homeostatic excitability.
- The genesis of seizures in vitro: axon terminal excitability.
- The kindling model of epilepsy: a critical review.
- The role of NMDA receptors in in vitro epileptogenesis.
- The role of substantia nigra in the development of kindling: pharmacologic and lesion studies.
- The tyrosine receptor kinase B ligand, neurotrophin-4, is not required for either epileptogenesis or tyrosine receptor kinase B activation in the kindling model.
- Unilateral kindling of the inferior collicular cortex does not transfer to the contralateral seizure sensitive site or alter [3H]flunitrazepam and [35S]TBPS binding.
- Vagus nerve stimulation elevates seizure threshold in the kindling model.
- gamma-Aminobutyric acid and benzodiazepine receptors in the kindling model of epilepsy: a quantitative radiohistochemical study.
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Keywords of People
- Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology