Kinetics

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  Subject Areas on Research

  • (3H)norepinephrine binding and lipolysis by isolated fat cells. 
  • 1,10-Phenanthroline reversibility inhibits proliferation of two human prostate carcinoma cell lines (PC-3 and DU145). 
  • 1,2-Diacylglycerol choline phosphotransferase catalyzes the final step in the unique Treponema denticola phosphatidylcholine biosynthesis pathway. 
  • 1,25-Dihydroxyvitamin D3 modulates glucocorticoid-induced alteration in serum bone Gla protein and bone histomorphometry. 
  • 13N,15N isotope and kinetic evidence against hyponitrite as an intermediate in dentrification. 
  • 31P NMR probes of chemical dynamics: paramagnetic relaxation enhancement of the (1)H and (31)P NMR resonances of methyl phosphite and methylethyl phosphate anions by selected metal complexes. 
  • 4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid inhibits CD3-T cell antigen receptor-stimulated Ca2+ influx in human T lymphocytes. 
  • 5-HT1A and histamine H1 receptors in HeLa cells stimulate phosphoinositide hydrolysis and phosphate uptake via distinct G protein pools. 
  • 5-Lipoxygenase products modulate the activity of the 85-kDa phospholipase A2 in human neutrophils. 
  • 57Fe and 1H electron-nuclear double resonance of three doubly reduced states Escherichia coli sulfite reductase. 
  • 8-ISO-PGF2alpha production by alveolar macrophages exposed to hyperoxia. 
  • A Bacterial Chromosome Structuring Protein Binds Overtwisted DNA to Stimulate Type II Topoisomerases and Enable DNA Replication. 
  • A CORRELATION BETWEEN THE PROTEIN STRUCTURE AND CATALYTIC ACTIVITY OF ASPARTATE AMINOTRANSFERASE. 
  • A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol. 
  • A G-quadruplex DNA-affinity Approach for Purification of Enzymatically Active G4 Resolvase1. 
  • A KINETIC INVESTIGATION OF THE INTERACTION OF ADENOSINE-5'-TRIPHOSPHATE WITH DIVALENT METAL IONS. 
  • A Monte Carlo model reveals independent signaling at central glutamatergic synapses. 
  • A THERMODYNAMIC STUDY OF THE HYDROLYSIS OF CYTIDINE 2',3'-CYCLIC PHOSPHATE. 
  • A beta-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination. 
  • A beta-lactam inhibitor of cytosolic phospholipase A2 which acts in a competitive, reversible manner at the lipid/water interface. 
  • A calorimetric and equilibrium investigation of the hydrolysis of lactose. 
  • A carbon monoxide irreducible form of cytochrome c oxidase and other unusual properties of the "monomeric" shark enzyme. 
  • A cell culture system that enhances mononuclear cell IgE synthesis induced by recombinant human interleukin-4. 
  • A central role for beta-arrestins and clathrin-coated vesicle-mediated endocytosis in beta2-adrenergic receptor resensitization. Differential regulation of receptor resensitization in two distinct cell types. 
  • A chemoattractant receptor on macrophages exists in two affinity states regulated by guanine nucleotides. 
  • A combination of two immunotoxins exerts synergistic cytotoxic activity against human breast-cancer cell lines. 
  • A comparison of methionine, histidine and cysteine in copper(I)-binding peptides reveals differences relevant to copper uptake by organisms in diverse environments. 
  • A complex pattern of disposition of phenytoin in severe intoxication. 
  • A comprehensive evaluation of catalase-like activity of different classes of redox-active therapeutics. 
  • A computer model of engineered cardiac monolayers. 
  • A conserved bulged adenosine in a peripheral duplex of the antigenomic HDV self-cleaving RNA reduceskinetic trapping of inactive conformations. 
  • A conserved region in alpha-macroglobulins participates in binding to the mammalian alpha-macroglobulin receptor. 
  • A contemporary prognostic nomogram for men with hormone-refractory metastatic prostate cancer: a TAX327 study analysis. 
  • A continuous fluorometric assay for the feline immunodeficiency virus protease. 
  • A continuously monitored spectrophotometric assay of glycosidases with nitrophenyl glycosides. 
  • A convenient LC-MS method for assessment of glucose kinetics in vivo with D-[13C6]glucose as a tracer. 
  • A cut above the other caspases. 
  • A fine line between molecular umbrella transport and ionophoric activity. 
  • A functional isoform of the human granulocyte/macrophage colony-stimulating factor receptor has an unusual cytoplasmic domain. 
  • A golden era for understanding enzyme mechanisms. 
  • A high affinity agonist . beta-adrenergic receptor complex is an intermediate for catecholamine stimulation of adenylate cyclase in turkey and frog erythrocyte membranes. 
  • A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration. 
  • A host protein (La) binds to a unique species of minus-sense leader RNA during replication of vesicular stomatitis virus. 
  • A hot oxidant, 3-NO2Y122 radical, unmasks conformational gating in ribonucleotide reductase. 
  • A kallikrein-targeting RNA aptamer inhibits the intrinsic pathway of coagulation and reduces bradykinin release. 
  • A kinesin motor in a force-producing conformation. 
  • A kinetic analysis using fractals of cellular analyte-receptor binding and dissociation. 
  • A kinetic investigation of the interaction of alpha-methylaspartic acid with aspartate aminotransferase. 
  • A kinetic investigation of the interaction of erythro-beta-hydroxyaspartic acid with aspartate aminotransferase. 
  • A kinetic study of embryonic cell adhesion. 
  • A kinetic study of the binding of an ADP fluorescent analog to mitochondrial ATPase. 
  • A kinetic study of the hydrogen-bond dimerization of 2-pyridone. 
  • A kinetic study of the subunit dissociation and reassembly of rabbit muscle phosphofructokinase. 
  • A laboratory batch reactor test for assessing nonspeciated volatile organic compound biodegradation in activated sludge. 
  • A mass spectrometry-based probe of equilibrium intermediates in protein-folding reactions. 
  • A mathematical model for analysis of pharmacologically induced changes in the kinetics of cardiac muscle. 
  • A mathematical model for the regulation of juvenile hormone titers. 
  • A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism. 
  • A mathematical model of glutathione metabolism. 
  • A mathematical model of the folate cycle: new insights into folate homeostasis. 
  • A mathematical model of tumor oxygen and glucose mass transport and metabolism with complex reaction kinetics. 
  • A mathematical model quantifying GnRH-induced LH secretion from gonadotropes. 
  • A miniaturized technique for assessing protein thermodynamics and function using fast determination of quantitative cysteine reactivity. 
  • A minimal TrpRS catalytic domain supports sense/antisense ancestry of class I and II aminoacyl-tRNA synthetases. 
  • A model of ribonuclease based on chemical evidence. 
  • A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster. 
  • A mutation in the largest subunit of RNA polymerase II alters RNA chain elongation in vitro. 
  • A new era in pharmacotherapy: the need to understand the principles of therapeutic drug monitoring. 
  • A new irreversibly inhibited form of xanthine oxidase from ethylisonitrile. 
  • A new procedure for the synthesis of polyethylene glycol-protein adducts; effects on function, receptor recognition, and clearance of superoxide dismutase, lactoferrin, and alpha 2-macroglobulin. 
  • A non-pungent resiniferatoxin analogue, phorbol 12-phenylacetate 13 acetate 20-homovanillate, reveals vanilloid receptor subtypes on rat trigeminal ganglion neurons. 
  • A nonantigenic covalent streptokinase-polyethylene glycol complex with plasminogen activator function. 
  • A novel approach for assessing protein synthesis in channel catfish, Ictalurus punctatus. 
  • A novel catecholamine-activated adenosine cyclic 3',5'-phosphate independent pathway for beta-adrenergic receptor phosphorylation in wild-type and mutant S49 lymphoma cells: mechanism of homologous desensitization of adenylate cyclase. 
  • A novel chloride channel in Vicia faba guard cell vacuoles activated by the serine/threonine kinase, CDPK. 
  • A novel method for measuring asymmetry in kinematic and kinetic variables: The normalized symmetry index. 
  • A peptide sequence on carcinoembryonic antigen binds to a 80kD protein on Kupffer cells. 
  • A pertussis/choleratoxin-sensitive N protein may mediate chemoattractant receptor signal transduction. 
  • A pharmacodynamic model to investigate the structure-activity profile of a series of novel opioid analgesics. 
  • A phosphotransferase that generates phosphatidylinositol 4-phosphate (PtdIns-4-P) from phosphatidylinositol and lipid A in Rhizobium leguminosarum. A membrane-bound enzyme linking lipid a and ptdins-4-p biosynthesis. 
  • A photolabile ligand for light-activated release of caged copper. 
  • A physiologic model of the dehydroepiandrosterone to estrogen conversion system in the fetoplacental unit. I. Development. 
  • A physiologic model of the dehydroepiandrosterone to estrogen conversion system in the fetoplacental unit. II. Preliminary clinical application--the dehydroepiandrosterone loading test. 
  • A potent superoxide dismutase mimic: manganese beta-octabromo-meso-tetrakis-(N-methylpyridinium-4-yl) porphyrin. 
  • A potential second messenger role for unsaturated fatty acids: activation of Ca2+-dependent protein kinase. 
  • A prochelator with a modular masking group featuring hydrogen peroxide activation with concurrent fluorescent reporting. 
  • A promoter deletion reduces the rate of mitotic, but not meiotic, recombination at the HIS4 locus in yeast. 
  • A prospective study of the epidemiology of adverse drug reactions in pediatric hematology and oncology patients. 
  • A pseudoknot in the 3' non-core region of the glmS ribozyme enhances self-cleavage activity. 
  • A quantitative description of QX222 blockade of sodium channels in squid axons. 
  • A quantitative model predicts how m6A reshapes the kinetic landscape of nucleic acid hybridization and conformational transitions. 
  • A randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis. 
  • A rapid fluorescence assay for FtsZ assembly indicates cooperative assembly with a dimer nucleus. 
  • A rapid method for the isolation and partial purification of specific eucaryotic messenger RNA's. 
  • A reappraisal of the concept of an abnormality of glutamine metabolism in primary gout. 
  • A requirement for ankyrin binding to clathrin during coated pit budding. 
  • A sensitive genetic assay for the detection of cytosine deamination: determination of rate constants and the activation energy. 
  • A sensitive, specific radioisotope assay for L-glutamine-D-fructose-6-phosphate aminotransferase. 
  • A single amino acid change in the cytoplasmic domain of the simian immunodeficiency virus transmembrane molecule increases envelope glycoprotein expression on infected cells. 
  • A single base substitution in the variable pocket of yeast tRNA(Arg) eliminates species-specific aminoacylation. 
  • A source of bias in the analysis of single channel data: assessing the apparent interaction between channel proteins. 
  • A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. 
  • A stable dimer in the pH-induced equilibrium unfolding of the homo-hexameric enzyme 4-oxalocrotonate tautomerase (4-OT). 
  • A statistical thermodynamic model of the protein ensemble. 
  • A structural pathway for activation of the kinesin motor ATPase. 
  • A structural pathway for signaling in the E46Q mutant of photoactive yellow protein. 
  • A study of pituitary function in patients with idiopathic hemochromatosis. 
  • A study of the binding of thiamine diphosphate and thiochrome diphosphate to the pyruvate dehydrogenase multienzyme complex. 
  • A substrate specific functional polymorphism of human gamma-glutamyl hydrolase alters catalytic activity and methotrexate polyglutamate accumulation in acute lymphoblastic leukaemia cells. 
  • A subtransition in a phospholipid with a net charge, dipalmitoylphosphatidylglycerol. 
  • A synthetic mimic of the secretory granule for drug delivery. 
  • A temperature jump study of aspartate aminotransferase. a reinvestigation. 
  • A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor. 
  • A thermodynamic study of the partition of n-hexane into phosphatidylcholine and phosphatidylcholine-cholesterol bilayers. 
  • A three-dimensional biomechanical analysis of sumo and conventional style deadlifts. 
  • A truncated form of fibroblast growth factor receptor 1 inhibits signal transduction by multiple types of fibroblast growth factor receptor. 
  • A voltage-gated calcium-selective channel encoded by a sodium channel-like gene. 
  • ACE and ACE2 activity in diabetic mice. 
  • ACTH-receptor interaction in the adrenal: a model for the initial step in the action of hormones that stimulate adenyl cyclase. 
  • ALS- and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy. 
  • AMPK and substrate availability regulate creatine transport in cultured cardiomyocytes. 
  • ATP hydrolysis by a CFTR domain: pharmacology and effects of G551D mutation. 
  • ATP-sensitive K+ channels in a plasma membrane H+-ATPase mutant of the yeast Saccharomyces cerevisiae. 
  • Abh and AbrB control of Bacillus subtilis antimicrobial gene expression. 
  • Abnormal optical waveform profiles in coagulation assays from patients with antiphospholipid antibodies. 
  • Absence of an effect of dietary corn oil content on plasma prolactin, progesterone, and 17 beta-estradiol in female Sprague-Dawley rats. 
  • Absorption filtration. A tool for the measurement of ion tracer flux in native membranes and reconstituted lipid vesicles. 
  • Abundant androgen regulated mRNAs in mouse submandibular gland: cell-free translation of renin precursor mRNA. 
  • Accelerated deamination of cytosine residues in UV-induced cyclobutane pyrimidine dimers leads to CC-->TT transitions. 
  • Accelerating massively parallel hemodynamic models of coarctation of the aorta using neural networks. 
  • Acceleration of myosin light chain dephosphorylation and relaxation of smooth muscle by telokin. Synergism with cyclic nucleotide-activated kinase. 
  • Accuracy and precision of a new H/D exchange- and mass spectrometry-based technique for measuring the thermodynamic properties of protein-peptide complexes. 
  • Acetylcholine receptors from electroplax membranes: in vitro and in situ properties. 
  • Acid phosphatase activity in subcellular fractions of fish liver exposed to methyl mercuric chloride. 
  • Acid- and base-catalyzed hydrolysis of chloroacetamide herbicides. 
  • Acrylamide in polyacrylamide gels can modify proteins during electrophoresis. 
  • Action of preoptic injections of beta-endorphin on temperature regulation in rabbits. 
  • Activated human plasma carboxypeptidase B is retained in the blood by binding to alpha2-macroglobulin and pregnancy zone protein. 
  • Activated protein C cleaves factor Va more efficiently on endothelium than on platelet surfaces. 
  • Activation and desensitization of beta-adrenergic receptor-coupled GTPase and adenylate cyclase of frog and turkey erythrocyte membranes. 
  • Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway. 
  • Activation of adenylate cyclase by beta-adrenergic receptors: investigation of rate limiting steps by simultaneous assay of high affinity agonist binding and GDP release. 
  • Activation of adenylate cyclase by phosphoramidate and phosphonate analogs of GTP: possible role of covalent enzyme-substrate intermediates in the mechanism of hormonal activation. 
  • Activation of beef heart mitochondrial adenosine triphosphatase by 2,4-dinitrophenol. 
  • Activation of four enzymes by two series of calmodulin mutants with point mutations in individual Ca2+ binding sites. 
  • Activation of human B lymphocytes. V. Kinetics and mechanisms of suppression of plaque-forming cell responses by concanavalin A-generated suppressor cells. 
  • Activation of human plasminogen by urokinase. Partial characterization of a pre-activation peptide. 
  • Activation of phenylalanine hydroxylase by phenylalanine. 
  • Activation of the heat shock transcription factor by hypoxia in mammalian cells. 
  • Activation of the parasympathetic nervous system is necessary for normal meal-induced insulin secretion in rhesus macaques. 
  • Activation of the respiratory burst enzyme in human polymorphonuclear leukocytes by chemoattractants and other soluble stimuli. Evidence that the same oxidase is activated by different transductional mechanisms. 
  • Activities of the initial enzymes of glycerolipid and sphingolipid synthesis in lung microsomes from rats exposed to air or 85% oxygen. 
  • Activity-dependent modulation of synaptic AMPA receptor accumulation. 
  • Acute respiratory failure and the kinetics of neutrophil recovery in pediatric hematopoietic cell transplantation: a multicenter study. 
  • Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver. 
  • Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase. Formation of N-palmitoyl-aminopentol produces a toxic metabolite of hydrolyzed fumonisin, AP1, and a new category of ceramide synthase inhibitor. 
  • Adding a positive charge at residue 46 of Drosophila alcohol dehydrogenase increases cofactor specificity for NADP+. 
  • Addressing biological uncertainties in engineering gene circuits. 
  • Adducin preferentially recruits spectrin to the fast growing ends of actin filaments in a complex requiring the MARCKS-related domain and a newly defined oligomerization domain. 
  • Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C. 
  • Adenine nucleotides of ischemic intestine do not reflect injury. 
  • Adenovirus inhibition of cellular protein synthesis involves inactivation of cap-binding protein. 
  • Adenovirus-mediated overexpression of liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in gluconeogenic rat hepatoma cells. Paradoxical effect on Fru-2,6-P2 levels. 
  • Adenovirus-mediated transfer of CCAAT/enhancer-binding protein-alpha identifies a dominant antiproliferative role for this isoform in hepatocytes. 
  • Adenovirus-mediated transfer of the muscle glycogen phosphorylase gene into hepatocytes confers altered regulation of glycogen metabolism. 
  • Adipocyte beta-adrenergic receptors. Identification and subcellular localization by (-)-[3H]dihydroalprenolol binding. 
  • Adrenal medullary storage vesicles of the spontaneously hypertensive rat. 
  • Adsorption of clofibric acid and ketoprofen onto powdered activated carbon: effect of natural organic matter. 
  • Advanced glycation end products contribute to amyloidosis in Alzheimer disease. 
  • Affinity chromatography of H+-translocating adenosine triphosphatase isolated by chloroform extraction of Rhodospirillum rubrum chromatophores. Modification of binding affinity by divalent cations and activating anions. 
  • Affinity of (alpha-P-borano)-NTP analogs to rabbit muscle pyruvate kinase. 
  • Agonist interactions with alpha-adrenergic receptors. 
  • Agonist-specific alterations in receptor binding affinity associated with solubilization of turkey erythrocyte membrane beta adrenergic receptors. 
  • Albumin influences sulfobromophthalein transport by hepatocytes of each acinar zone. 
  • Alkaline Phosphatase in Infant Cardiopulmonary Bypass: Kinetics and Relationship to Organ Injury and Major Cardiovascular Events. 
  • All-or-none secretion of adrenal medullary storage vesicle contents in the rat. 
  • Allosteric activation of proto-oncogene kinase Src by GPCR-beta-arrestin complexes. 
  • Allosteric interactions in non-alpha chains isolated from normal human hemoglobin, fetal hemoglobin, and hemoglobin Abruzzo (beta143 (H21) His replaced by Arg). 
  • Allosteric regulation of type I hexokinase: A site-directed mutational study indicating location of the functional glucose 6-phosphate binding site in the N-terminal half of the enzyme. 
  • Allostery in Callinectes sapidus hemocyanin: cooperative oxygen binding and interactions with L-lactate, calcium, and protons. 
  • Alpha 1-adrenergic receptor mRNA level is regulated by norepinephrine in rabbit aortic smooth muscle cells. 
  • Alpha 1-adrenergic receptor-mediated downregulation of angiotensin II receptors in neuronal cultures. 
  • Alpha 2 macroglobulin-proteinase complexes stimulate prostaglandin E2 synthesis by peritoneal macrophages. 
  • Alpha-adrenergic receptor identification by (3H)dihydroergocryptine binding. 
  • Alpha-adrenergic receptor subtypes: quantitative assessment by ligand binding. 
  • Alteration and restoration of K+ channel function by deletions at the N- and C-termini. 
  • Alteration by methadone of catecholamine uptake and release in isolated rat adrenomedullary storage vesicles. 
  • Alterations in an inositol phosphate code through synergistic activation of a G protein and inositol phosphate kinases. 
  • Alterations in left ventricular diastolic function in conscious dogs with pacing-induced heart failure. 
  • Alterations in the development of catecholamine turnover induced by perinatal methadone: differences in central vs. peripheral sympathetic nervous systems. 
  • Altered clearance of human alpha 2-macroglobulin complexes following reaction with cis-dichlorodiamineplatinum(II). 
  • Altered cyclic AMP-dependent human chorionic gonadotropin production in cultured human placental trophoblasts exposed to ethanol. 
  • Altered distribution of mitochondria and actin fibers in 3T3 cells cultured on microcarriers. 
  • Altered genetic response to beta-adrenergic receptor activation in late passage C6 glioma cells. 
  • Altered light responses of single rod photoreceptors in transgenic pigs expressing P347L or P347S rhodopsin. 
  • Altered regulation of S-adenosylmethionine dependent methylation in adenosine deaminase deficiency. 
  • Alternative explanation for the apparent "two-step" binding kinetics of high-affinity racemic antagonist radioligands. 
  • Aluminum-induced DNA synthesis in osteoblasts: mediation by a G-protein coupled cation sensing mechanism. 
  • Amino acid sequence of the nucleotide binding region of chloroplast coupling factor 1. 
  • Amino acid uptake by isolated renal brush border membrane vesicles in various buffers. 
  • Amphitrite ornata erythrocruorin. II. Molecular controls of function. 
  • Amphotericin B therapy in an anephric patient. 
  • Amygdala kindling induces muscarinic cholinergic receptor declines in a highly specific distribution within the limbic system. 
  • An Engineered Metal Sensor Tunes the Kinetics of Synaptic Transmission. 
  • An NMR study of the rates of single-molecule exchange in a cylindrical host capsule. 
  • An active site tyrosine influences the ability of the dimethyl sulfoxide reductase family of molybdopterin enzymes to reduce S-oxides. 
  • An amphipathic helix enables septins to sense micrometer-scale membrane curvature. 
  • An antibody-free dual-biomarker rapid enrichment workflow (AnDREW) improves the sensitivity of malaria rapid diagnostic tests. 
  • An assay for alpha-adrenergic receptor subtypes using [3H]dihydroergocryptine. 
  • An automated method for nonparametric kinetic analysis of clinical DCE-MRI data: application to glioblastoma treated with bevacizumab. 
  • An electromyographic analysis of sumo and conventional style deadlifts. 
  • An electrophysiological analysis of oxygen and pressure on synaptic transmission. 
  • An empirical model for electrostatic interactions in proteins incorporating multiple geometry-dependent dielectric constants. 
  • An endogenous source of the superoxide anion in the central nervous system. 
  • An equilibrium binding study of the interaction of aspartate transcarbamylase with cytidine 5'-triphosphate and adenosine 5'-triphosphate. 
  • An equilibrium binding study of the interaction of fructose 6-phosphate and fructose 1,6-bisphosphate with rabbit muscle phosphofructokinase. 
  • An equilibrium model of endothelial cell adhesion via integrin-dependent and integrin-independent ligands. 
  • An experimental and theoretical study of ring closing dynamics in HN3. 
  • An in vivo platform for translational drug development in pancreatic cancer. 
  • An investigation of the equilibria between aqueous ribose, ribulose, and arabinose. 
  • An unbiased evaluation of CK2 inhibitors by chemoproteomics: characterization of inhibitor effects on CK2 and identification of novel inhibitor targets. 
  • Anaerobic oxidations of myoglobin and hemoglobin by spectroelectrochemistry. 
  • Analog Computation by DNA Strand Displacement Circuits. 
  • Analyses of promoter-proximal pausing by RNA polymerase II on the hsp70 heat shock gene promoter in a Drosophila nuclear extract. 
  • Analysis of Homeostatic Mechanisms in Biochemical Networks. 
  • Analysis of calcium homeostasis in activated human polymorphonuclear leukocytes. Evidence for two distinct mechanisms for lowering cytosolic calcium. 
  • Analysis of experimental time-resolved crystallographic data by singular value decomposition. 
  • Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan. 
  • Analysis of ligand binding specificity of receptor chimeras. 
  • Analysis of medaka cytochrome P450 3A homotropic and heterotropic cooperativity. 
  • Analysis of messenger ribonucleic acid and protein for the ligands and receptors of the platelet-derived growth factor signaling pathway in the placenta, extraembryonic membranes, and uterus during the latter half of murine gestation. 
  • Analysis of recombinant Phex: an endopeptidase in search of a substrate. 
  • Analysis of the action of lidocaine on insect sodium channels. 
  • Analysis of the effect of three different allosteric ligands on oxygen binding by hemocyanin of the shrimp, Penaeus setiferus. 
  • Analysis of the kinetic mechanism of recombinant human isoprenylcysteine carboxylmethyltransferase (Icmt). 
  • Analysis of the plasma elimination kinetics and conformational stabilities of native, proteinase-complexed, and reactive site cleaved serpins: comparison of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, antithrombin III, alpha 2-antiplasmin, angiotensinogen, and ovalbumin. 
  • Analysis of trans-acting response decoy RNA-mediated inhibition of human immunodeficiency virus type 1 transactivation. 
  • Analytical Treatment Interruption after Short-Term Antiretroviral Therapy in a Postnatally Simian-Human Immunodeficiency Virus-Infected Infant Rhesus Macaque Model. 
  • Analyzing fibrin clot structure using a microplate reader. 
  • Anastral spindle assembly: a mathematical model. 
  • Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells 
  • Androgen stimulation of gross cystic disease fluid protein and carcinoembryonic antigen in patients with metastatic breast carcinoma. 
  • Angiotensin converting enzyme and genetic hypertension: cloning of rat cDNAs and characterization of the enzyme. 
  • Anion modulation of the negative Bohr effect of haemoglobin from a primitive amphibian. 
  • Ankyrin and spectrin associate with voltage-dependent sodium channels in brain. 
  • Ankyrin and synapsin: spectrin-binding proteins associated with brain membranes. 
  • Ankyrin-independent membrane protein-binding sites for brain and erythrocyte spectrin. 
  • Anoxia induces phospholipase A2 activation in rabbit renal proximal tubules. 
  • Antagonism of catecholamine receptor signaling by expression of cytoplasmic domains of the receptors. 
  • Anthracenedione activation by NADPH-cytochrome P-450 reductase; comparison with anthracyclines. 
  • Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce beta-chemokines. 
  • Antiarrhythmic drug action. Blockade of the inward sodium current. 
  • Antibodies raised against purified beta-adrenergic receptors specifically bind beta-adrenergic ligands. 
  • Antibody inhibitors of nonmuscle myosin function and assembly. 
  • Antibody-antigen binding kinetics. A model for multivalency antibodies for large antigen systems. 
  • Antibody-dependent cytolysis (ADCC) of tumor cells by activated murine macrophages is a two-step process: quantification of target binding and subsequent target lysis. 
  • Antioxidant enzyme activities and malondialdehyde, glutathione and methemoglobin concentrations in channel catfish exposed to DEF and n-butyl mercaptan. 
  • Antisense DNA downregulation of the ERBB2 oncogene measured by a flow cytometric assay. 
  • Antiviral activity of mismatched double-stranded RNA against human immunodeficiency virus in vitro. 
  • Apolipoprotein E and mimetic peptide initiate a calcium-dependent signaling response in macrophages. 
  • Apoptosis rate can be accelerated or decelerated by overexpression or reduction of the level of elongation factor-1 alpha. 
  • Apparent suicide inactivation of human lymphoblast S-adenosylhomocysteine hydrolase by 2'-deoxyadenosine and adenine arabinoside. A basis for direct toxic effects of analogs of adenosine. 
  • Appendices. Kinetic models for the analysis of modulation and suppression of irreversible enzymatic inhibition. 
  • Application of queueing theory to pharmacokinetics. 
  • Aquaglyceroporin AQP9: solute permeation and metabolic control of expression in liver. 
  • Aqueous two-phase system formation kinetics for elastin-like polypeptides of varying chain length 
  • Arachidonate and related unsaturated fatty acids selectively inactivate the guanine nucleotide-binding regulatory protein, Gz. 
  • Arachidonic acid stimulates mucin secretion in prairie dog gallbladder. 
  • Aridity weakens population-level effects of multiple species interactions on Hibiscus meyeri . 
  • Arrestin translocation is induced at a critical threshold of visual signaling and is superstoichiometric to bleached rhodopsin. 
  • Assay and detection of the molybdenum cofactor. 
  • Assay of G-protein beta gamma-subunit complex by catalytic support of ADP-ribosylation of Go alpha. 
  • Assembly and calcium-induced cooperativity of Limulus IV hemocyanin: a model system for analysis of structure-function relationships in the absence of subunit heterogeneity. 
  • Assembly dynamics of Mycobacterium tuberculosis FtsZ. 
  • Assembly of alternating polycation and DNA multilayer films by electrostatic layer-by-layer adsorption. 
  • Assembly of pure tubulin in the absence of free GTP: effect of magnesium, glycerol, ATP, and the nonhydrolyzable GTP analogues. 
  • Assessment of disparate structural features in three models of the hepatitis delta virus ribozyme. 
  • Association of ebola virus matrix protein VP40 with microtubules. 
  • Asteropsin A: an unusual cystine-crosslinked peptide from porifera enhances neuronal Ca2+ influx. 
  • Augmentation of human monocyte chemotactic response by levamisole. 
  • Autocrine inhibition of Na+/K(+)-ATPase by nitric oxide in mouse proximal tubule epithelial cells. 
  • Axonal transport of [35S]methionine-labeled proteins in two intra-brain tracts of the rat. 
  • Axonal transport of [3H]fucose-labeled glycoproteins in two intra-brain tracts of the rat. 
  • B cell antigen receptor and CD40 differentially regulate CD22 tyrosine phosphorylation. 
  • BMP-2 and BMP-9 promotes chondrogenic differentiation of human multipotential mesenchymal cells and overcomes the inhibitory effect of IL-1. 
  • Backbone dynamics of homologous fibronectin type III cell adhesion domains from fibronectin and tenascin. 
  • Bacterial infection of osteoblasts induces interleukin-1beta and interleukin-18 transcription but not protein synthesis. 
  • Bacterially synthesized vertebrate calmodulin is a specific substrate for ubiquitination. 
  • Bactericidal antibiotics increase tumor necrosis factor-alpha and cardiac output in rats after cecal ligation and puncture. 
  • Bacteriophage inactivation by UV-A illuminated fullerenes: role of nanoparticle-virus association and biological targets. 
  • Barbiturate and picrotoxin-sensitive chloride efflux in rat cerebral cortical synaptoneurosomes. 
  • Barbiturate-induced alterations in the kinetic parameters of slow outward current in Aplysia giant neurons. 
  • Base-boronated dinucleotides: synthesis and effect of N7-cyanoborane substitution on the base protons. 
  • Basic fibroblast growth factor downregulates Bcl-2 and promotes apoptosis in MCF-7 human breast cancer cells. 
  • Basis for resistance to 3-deazaaristeromycin, an inhibitor of S-adenosylhomocysteine hydrolase, in human B-lymphoblasts. 
  • Benzodiazepine receptor increases after repeated seizures: evidence for localization to dentate granule cells. 
  • Bepridil and cetiedil. Vasodilators which inhibit Ca2+-dependent calmodulin interactions with erythrocyte membranes. 
  • Beryllium(II) binding to ATP and ADP: potentiometric determination of the thermodynamic constants and implications for in vivo toxicity. 
  • Beta-Adrenergic receptors: solubilization of (-)(3H)alprenolol binding sites from frog erythrocyte membranes. 
  • Beta-adrenergic receptor sequestration. A potential mechanism of receptor resensitization. 
  • Beta-adrenergic receptors: evidence for negative cooperativity. 
  • Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. 
  • Biased agonism as a mechanism for differential signaling by chemokine receptors. 
  • Biliary excretion of glycolipid in induced or inherited glucosylceramide lipidosis. 
  • Binding and endocytosis of alpha 2-macroglobulin-plasmin complexes. 
  • Binding and signaling of surface-immobilized reagentless fluorescent biosensors derived from periplasmic binding proteins. 
  • Binding kinetics of superantigen with TCR and MHC class II. 
  • Binding of 3H-phenamil, an irreversible amiloride analog, to toad urinary bladder: effects of aldosterone and vasopressin. 
  • Binding of MetJ repressor to specific and nonspecific DNA and effect of S-adenosylmethionine on these interactions. 
  • Binding of alpha 2-macroglobulin-thrombin complexes and methylamine-treated alpha 2-macroglobulin to human blood monocytes. 
  • Binding of placental lactogen and growth hormone to fetal sheep fibroblasts. 
  • Binding of purified and radioiodinated capsular polysaccharides from Cryptococcus neoformans serotype A strains to capsule-free mutants. 
  • Binding of tissue-type plasminogen activator to the glucose-regulated protein 78 (GRP78) modulates plasminogen activation and promotes human neuroblastoma cell proliferation in vitro. 
  • Binding of warfarin influences the acid-base equilibrium of H242 in sudlow site I of human serum albumin. 
  • Binding site for C4b-binding protein in vitamin K-dependent protein S fully contained in carboxy-terminal laminin-G-type repeats. A study using recombinant factor IX-protein S chimeras and surface plasmon resonance. 
  • Binding stoichiometry and structural mapping of the epsilon polypeptide of chloroplast coupling factor 1. 
  • Bioavailability of terfenadine in man. 
  • Biochemical characterization of the beta-adrenergic receptor of the frog erythrocyte. 
  • Biochemical characterization of the multifunctional Ca2+/calmodulin-dependent protein kinase type IV expressed in insect cells. 
  • Biochemical fractionation and assembly of the membrane components that mediate nascent chain targeting and translocation. 
  • Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis. 
  • Biochemistry and theory of proton-coupled electron transfer. 
  • Biochemistry. Photosynthesis from the protein's perspective. 
  • Biocompatible hydrogels by oxime Click chemistry 
  • Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. 
  • Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring. 
  • Biological activity of complement in vivo. Role of C5 in the accumulation of polymorphonuclear leukocytes in inflammatory exudates. 
  • Biological charge transfer via flickering resonance. 
  • Biosynthesis of nitric oxide and citrulline from L-arginine by constitutive nitric oxide synthase present in rabbit corpus cavernosum. 
  • Biotreatment of groundwater contaminated with MTBE: interaction of common environmental co-contaminants. 
  • Bisulfite induces tandem double CC-->TT mutations in double-stranded DNA. 2. Kinetics of cytosine deamination. 
  • Blockade of cardiac sodium channels by lidocaine. Single-channel analysis. 
  • Blockade of rabbit atrial sodium channels by lidocaine. Characterization of continuous and frequency-dependent blocking. 
  • Blood-to-brain glucose transport, cerebral glucose metabolism, and cerebral blood flow are not increased after hypoglycemia. 
  • Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor. 
  • Bone sialoprotein-collagen interaction promotes hydroxyapatite nucleation. 
  • Boranophosphates support the RNase H cleavage of polyribonucleotides. 
  • Both insulin and epidermal growth factor stimulate lipogenesis and acetyl-CoA carboxylase activity in isolated adipocytes. Importance of homogenization procedure in avoiding artefacts in acetyl-CoA carboxylase assay. 
  • Both stimulatory and inhibitory GDP/GTP exchange proteins, smg GDS and rho GDI, are active on multiple small GTP-binding proteins. 
  • Brain Arachidonic Acid Incorporation and Turnover are not Altered in the Flinders Sensitive Line Rat Model of Human Depression. 
  • Breakage of single-stranded DNA by rat liver nicking-closing enzyme with the formation of a DNA-enzyme complex. 
  • Breaking the simple proportionality between molecular conductances and charge transfer rates. 
  • Brefeldin A promotes hydrolysis of sphingomyelin. 
  • BtubA-BtubB heterodimer is an essential intermediate in protofilament assembly. 
  • Buthionine sulfoximine induction of gamma-L-glutamyl-L-cysteine synthetase gene expression, kinetics of glutathione depletion and resynthesis, and modulation of carmustine-induced DNA-DNA cross-linking and cytotoxicity in human glioma cells. 
  • C-Terminal glycine-gated radical initiation by GTP 3',8-cyclase in the molybdenum cofactor biosynthesis. 
  • C-nitroso compounds: synthesis, physicochemical properties and biological activities. 
  • C-nitroso donors of nitric oxide. 
  • CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung. 
  • CD10/neutral endopeptidase 24.11 regulates fetal lung growth and maturation in utero by potentiating endogenous bombesin-like peptides. 
  • CD14-dependent mechanism for endotoxin-mediated nitric oxide synthesis in murine macrophages. 
  • CO binding by hemocyanins of Limulus polyphemus, Busycon carica, and Callinectes sapidus. 
  • CX3CR1 tyrosine sulfation enhances fractalkine-induced cell adhesion. 
  • CYP3A probes can quantitatively predict the in vivo kinetics of other CYP3A substrates and can accurately assess CYP3A induction and inhibition. 
  • Ca2+-dependent regulation of cyclic-AMP phosphodiesterase by parvalbumin. 
  • Ca2+-sensitive inactivation and facilitation of L-type Ca2+ channels both depend on specific amino acid residues in a consensus calmodulin-binding motif in the(alpha)1C subunit. 
  • Cadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site. 
  • Cadmium-induced DNA synthesis and cell proliferation in macrophages: the role of intracellular calcium and signal transduction mechanisms. 
  • Calcium binding is required for calmodulin function in Aspergillus nidulans. 
  • Calcium channel function regulated by the SH3-GK module in beta subunits. 
  • Calcium channels reconstituted from the skeletal muscle dihydropyridine receptor protein complex and its alpha 1 peptide subunit in lipid bilayers. 
  • Calcium control of muscle phosphorylase kinase through the combined action of calmodulin and troponin. 
  • Calcium-independent phospholipase A2 participates in KCl-induced calcium sensitization of vascular smooth muscle. 
  • Calcium/calmodulin inhibits direct binding of spectrin to synaptosomal membranes. 
  • Calcium/calmodulin-dependent protein kinase II. Characterization of distinct calmodulin binding and inhibitory domains. 
  • Calculation on fluorescence resonance energy transfer on surfaces. 
  • Calmodulin activation of target enzymes. Consequences of deletions in the central helix. 
  • Calmodulin in bovine rod outer segments. 
  • Calmodulin is involved in regulation of cell proliferation. 
  • Calmodulin. Development and application of a sensitive radioimmunoassay. 
  • Calorimetric analysis of the binding of lectins with overlapping carbohydrate-binding ligand specificities. 
  • Candidate topical microbicides bind herpes simplex virus glycoprotein B and prevent viral entry and cell-to-cell spread. 
  • Carbohydrate recognition systems in amphibians: primitive alpha 2-macroglobulin receptors. 
  • Carbon monoxide binding by hemoglobin and myoglobin under photodissociating conditions. 
  • Carbon monoxide binding by simple heme proteins under photodissociating conditions. 
  • Carbon monoxide-driven reduction of ferric heme and heme proteins. 
  • Carcinoembryonic antigen binding proteins on elicited peritoneal macrophages. 
  • Cardiac transient outward potassium current: a pulse chemistry model of frequency-dependent properties. 
  • Cardiopulmonary bypass induces leukocyte-platelet adhesion. 
  • Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial. 
  • Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex. 
  • Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer. 
  • Catalytic scavenging of peroxynitrite by isomeric Mn(III) N-methylpyridylporphyrins in the presence of reductants. 
  • Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. 
  • Catecholamine binding to the beta-adrenergic receptor. 
  • Catecholamine stimulated myocardial adenylate cyclase: effects of nucleotides. 
  • Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptor binding sites. 
  • Cathepsin B1. A lysosomal enzyme that degrades native collagen. 
  • Cation-Activated Avidity for Rapid Reconfiguration of DNA Nanodevices. 
  • Cell adhesion to fibronectin and tenascin: quantitative measurements of initial binding and subsequent strengthening response. 
  • Cell adhesion to fibronectin and tenascin: quantitative measurements of initial binding and subsequent strengthening response. 
  • Cell cycle kinetic effects of tamoxifen on human breast cancer cells. Flow cytometric analyses of DNA content, BrdU labeling, Ki-67, PCNA, and statin expression. 
  • Cell surface adenosine deaminase binds and stimulates plasminogen activation on 1-LN human prostate cancer cells. 
  • Cell surface annexin II is a high affinity receptor for the alternatively spliced segment of tenascin-C. 
  • Cell-free desensitization of catecholamine-sensitive adenylate cyclase. Agonist- and cAMP-promoted alterations in turkey erythrocyte beta-adrenergic receptors. 
  • Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor. 
  • Cellular pharmacokinetic and pharmacodynamic analyses of ethacrynic acid: Implications in topical drug delivery in the eye. 
  • Central catecholaminergic lesions in the developing rat: effects of cardiac noradrenaline levels, turnover and release. 
  • Ceramide content is increased in skeletal muscle from obese insulin-resistant humans. 
  • Ceramide synthase. 
  • Cerebral glucose transport and metabolism in preterm human infants. 
  • Cerebral transport and metabolism of 1-11C-D-glucose during stepped hypoglycemia. 
  • Changes in bioactive lipids, alkylacylglycerol and ceramide, occur in HIV-infected cells. 
  • Changes in the binding of "fast"-form alpha 2-macroglobulin to 3T3-L1 cells after differentiation to adipocytes. 
  • Changes in the rate of laminin and entactin synthesis in F9 embryonal carcinoma cells treated with retinoic acid and cyclic amp. 
  • Chaperones rescue luciferase folding by separating its domains. 
  • Characteristics of 5'-guanylyl imidodiphosphate-activated adenylate cyclase. 
  • Characteristics of creatine kinase-MB and MB isoforms in serum after reperfusion in acute myocardial infarction. 
  • Characteristics of lysine transport by isolated rat renal cortical tubule fragments. 
  • Characteristics of lysine uptake by isolated renal cortical tubule fragments from mature and immature dogs. 
  • Characterization and mechanistic study of a radical SAM dehydrogenase in the biosynthesis of butirosin. 
  • Characterization of ATP-independent ERK inhibitors identified through in silico analysis of the active ERK2 structure. 
  • Characterization of Acyl Carrier Protein-Dependent Glycosyltransferase in Mitomycin C Biosynthesis. 
  • Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation. 
  • Characterization of Fe(III) sequestration by an analog of the cytotoxic siderophore brasilibactin A: implications for the iron transport mechanism in mycobacteria. 
  • Characterization of GABAA receptor-mediated 36chloride uptake in rat brain synaptoneurosomes. 
  • Characterization of GRK2-catalyzed phosphorylation of the human substance P receptor in Sf9 membranes. 
  • Characterization of Mn(III) complexes of linear and cyclic desferrioxamines as mimics of superoxide dismutase activity. 
  • Characterization of a Ca2+-calmodulin-stimulated cyclic GMP phosphodiesterase from bovine brain. 
  • Characterization of a human plasma membrane heme transporter in intestinal and hepatocyte cell lines. 
  • Characterization of a monoclonal antibody specific for human active renin. 
  • Characterization of acetylcholine receptor isolated from Torpedo californica electroplax through the use of an easily removable detergent, beta-D-octylglucopyranoside. 
  • Characterization of alpha 2-macroglobulin binding to human trabecular meshwork cells: presence of the alpha 2-macroglobulin signaling receptor. 
  • Characterization of alpha 2-macroglobulin-plasmin complexes: complete subunit cleavage alters receptor recognition in vivo and in vitro. 
  • Characterization of complexes between Escherichia coli sulfite reductase hemoprotein subunit and its substrates sulfite and nitrite. 
  • Characterization of concentration- and use-dependent effects of quinidine from conduction delay and declining conduction velocity in canine Purkinje fibers. 
  • Characterization of human alpha 2-macroglobulin monomers obtained by reduction with dithiothreitol. 
  • Characterization of human chemotactic lymphokine production induced by mitogens and mixed leukocyte reactions using a new microassay. 
  • Characterization of microtubule-associated protein MAP1B: phosphorylation state, light chains, and binding to microtubules. 
  • Characterization of murine peritoneal macrophage receptors for fibrin(ogen) degradation products. 
  • Characterization of non-equilibrium nanoparticle adsorption on a model biological substrate. 
  • Characterization of nuclear angiotensin-II-binding sites in rat liver and comparison with plasma membrane receptors. 
  • Characterization of prenylcysteines that interact with P-glycoprotein and inhibit drug transport in tumor cells. 
  • Characterization of purified rabbit uterine renin: influence of pregnancy on uterine inactive renin. 
  • Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I. 
  • Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts. 
  • Characterization of the flavoprotein moieties of NADPH-sulfite reductase from Salmonella typhimurium and Escherichia coli. Physicochemical and catalytic properties, amino acid sequence deduced from DNA sequence of cysJ, and comparison with NADPH-cytochrome P-450 reductase. 
  • Characterization of the insulinotropic potency of polyunsaturated fatty acids. 
  • Characterization of the interaction between alpha2-macroglobulin and fibroblast growth factor-2: the role of hydrophobic interactions. 
  • Characterization of the multiple transferable resistance repressor, MtrR, from Neisseria gonorrhoeae. 
  • Characterization of the murine BEK fibroblast growth factor (FGF) receptor: activation by three members of the FGF family and requirement for heparin. 
  • Characterization of the role of the amino-terminal proline in the enzymatic activity catalyzed by macrophage migration inhibitory factor. 
  • Characterization of three-subunit chloroplast coupling factor. 
  • Characterization of thromboxane receptor blocking effects of SQ 29548 in the feline pulmonary vascular bed. 
  • Characterizing RNA Excited States Using NMR Relaxation Dispersion. 
  • Characterizing RNA dynamics at atomic resolution using solution-state NMR spectroscopy. 
  • Characterizing the in vitro hepatic biotransformation of the flame retardant BDE 99 by common carp. 
  • Charge Transport across DNA-Based Three-Way Junctions. 
  • Chemical and structural modifications of alpha 2-macroglobulin: effects on receptor binding and endocytosis studied in an in vivo model. 
  • Chemical aspects of siderophore mediated iron transport. 
  • Chemical carcinogenesis and toxicity models: matching complexity to objectives. 
  • Chemical modification and fluorescence studies of chloroplast coupling factor. 
  • Chemical modification and site-directed mutagenesis of conserved HXXH and PP-loop motif arginines and histidines in the murine bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate kinase. 
  • Chemical rescue, multiple ionizable groups, and general acid-base catalysis in the HDV genomic ribozyme. 
  • Chemical waves in cell and developmental biology. 
  • Chemoattractant receptor affinity reflects its ability to transduce different biological responses. 
  • Chemoattractant receptor functions in human polymorphonuclear leukocytes are divergently altered by membrane fluidizers. 
  • Chirality affects aggregation kinetics of single-walled carbon nanotubes. 
  • Chloride and pH dependence of cooperative interactions in Limulus polyphemus hemocyanin. 
  • Chloride masks effects of opposing positive charges in Hb A and Hb Hinsdale (beta 139 Asn-->Lys) that can modulate cooperativity as well as oxygen affinity. 
  • Chloroplast coupling factor 1: dependence of rotational correlation time on polypeptide composition. 
  • Chlorpromazine methiodide-induced barrel rotation: an antimuscarinic effect. 
  • Cholesterol homeostasis in the rat with a portacaval anastomosis. 
  • Cholesterol interaction with the daunorubicin binding site of P-glycoprotein. 
  • Chondrocyte transport and concentration of ascorbic acid is mediated by SVCT2. 
  • Chromium(VI) treatment of normal human lung cells results in guanine-specific DNA polymerase arrest, DNA-DNA cross-links and S-phase blockade of cell cycle. 
  • Chromogenic assay for phospholipase C from Bacillus cereus. 
  • Chronic growth hormone treatment in normal rats reduces post-prandial skeletal muscle plasma membrane GLUT1 content, but not glucose transport or GLUT4 expression and localization. 
  • Chronic morphine administration alters epinephrine uptake in rat adrenal storage vesicles. 
  • Clamp subunit dissociation dictates bacteriophage T4 DNA polymerase holoenzyme disassembly. 
  • Clearance and binding of two electrophoretic "fast" forms of human alpha 2-macroglobulin. 
  • Clinical physiology of adrenergic receptor regulation. 
  • Clinical utility of total HCV core antigen quantification: a new indirect marker of HCV replication. 
  • Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase. 
  • Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. 
  • Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate. 
  • Cloning and characterization of a mammalian prenyl protein-specific protease. 
  • Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters. 
  • Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype. 
  • Cloning and expression of full-length cDNA encoding human vitamin D receptor. 
  • Cloning efficiency of cultured human tumor cell lines measured with the use of a Coulter particle counter. 
  • Cloning of cDNA and analysis of the gene for mouse angiotensin II type 2 receptor. 
  • Cloning of mitogen- and antigen-reactive B lymphocytes on filter paper discs. II. Paratope frequencies within the mitogen-selected repertoire. 
  • Cloning, expression, and cellular localization of a human prenylcysteine lyase. 
  • Cloning, isolation and characterization of the Thermotoga maritima KDPG aldolase. 
  • Clustered charged amino acids of human adenosine deaminase comprise a functional epitope for binding the adenosine deaminase complexing protein CD26/dipeptidyl peptidase IV. 
  • Clusterin promotes the aggregation and adhesion of renal porcine epithelial cells. 
  • Co-operative interactions between troponin-tropomyosin units extend the length of the thin filament in skeletal muscle. 
  • Co-operativity in protein-protein association. The structure and stability of the actin filament. 
  • Colloid chemical approach to nanoelectrode ensembles with highly controllable active area fraction. 
  • Commentary on: ferrokinetics in the syndrome of familial hypoferremic microcytic anemia with iron malabsorption. 
  • Comparative antidopaminergic properties of thioridazine, mesoridazine and sulforidazine on the corpus striatum. 
  • Comparative properties of channel catfish (Ictalurus punctatus) and blue crab (Callinectes sapidus) acetylcholinesterases. 
  • Comparative rates of desensitization of beta-adrenergic receptors by the beta-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase. 
  • Comparison of PSGL-1 microbead and neutrophil rolling: microvillus elongation stabilizes P-selectin bond clusters. 
  • Comparison of amphotericin B and N-D-ornithyl amphotericin B methyl ester in experimental cryptococcal meningitis and Candida albicans endocarditis with pyelonephritis. 
  • Comparison of cytostatic sensitivities of L 1210 cells and human stimulated lymphocytes in three cell proliferation assays. 
  • Comparison of electrokinetic properties of colloidal fullerenes (n-C60) formed using two procedures. 
  • Comparison of monoamine oxidase in golden hamster islets and insulinoma. 
  • Comparison of monoclonal antibody delivery to intracranial glioma xenografts by intravenous and intracarotid administration. 
  • Comparison of plasminogen binding and activation on extracellular matrices produced by vascular smooth muscle and endothelial cells. 
  • Comparison of the functional differences for the homologous residues within the carboxy phosphate and carbamate domains of carbamoyl phosphate synthetase. 
  • Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE. 
  • Comparison of the physical and functional properties of the 48-subunit native molecule and the 24- and 12-subunit dissociation intermediates of Limulus polyphemus hemocyanin. 
  • Compartmental transport model of microbicide delivery by an intravaginal ring. 
  • Competition in oxygen-linked anion binding to normal and variant human hemoglobins. 
  • Competition of hydrophobic peptides, cytotoxic drugs, and chemosensitizers on a common P-glycoprotein pharmacophore as revealed by its ATPase activity. 
  • Completeness of HIV-1 Envelope Glycan Shield at Transmission Determines Neutralization Breadth. 
  • Complex binding of L-[3H]glutamate to hippocampal synaptic membranes in the absence of sodium. 
  • Complex-dependent inhibition of factor VIIa by antithrombin III and heparin. 
  • Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta. 
  • Computational design of a biologically active enzyme. 
  • Computational kinetic model of VEGF trapping by soluble VEGF receptor-1: effects of transendothelial and lymphatic macromolecular transport. 
  • Computational study on the relative acidity of acetic acid by the qm/mm method combined with the theory of energy representation 
  • Computer simulations of morphologically reconstructed CA3 hippocampal neurons. 
  • Concerning the hormonal regulation of androgen binding protein in rat testis. 
  • Concerted O atom-proton transfer in the O-O bond forming step in water oxidation. 
  • Concomitant development of [3H]-dopamine and [3H]-5-hydroxytryptamine uptake systems in rat brain regions. 
  • Concurrent aggregation and deposition of TiO2 nanoparticles in a sandy porous media. 
  • Concurrent autoreceptor-mediated control of dopamine release and uptake during neurotransmission: an in vivo voltammetric study. 
  • Concurrent measurements of blood flow and transcapillary transport in xenotransplanted human gliomas in immunosuppressed rats. 
  • Conditional Silencing of H-2Db Class I Molecule Expression Modulates the Protective and Pathogenic Kinetics of Virus-Antigen-Specific CD8 T Cell Responses during Theiler's Virus Infection. 
  • Conditions for conducting the indirect hemolysis test for detection of antibodies to Brucella abortus. 
  • Confirmation of the involvement of protein domain movement during the catalytic cycle of the cytochrome bc1 complex by the formation of an intersubunit disulfide bond between cytochrome b and the iron-sulfur protein. 
  • Conformation-assisted inhibition of protein-tyrosine phosphatase-1B elicits inhibitor selectivity over T-cell protein-tyrosine phosphatase. 
  • Conformational kinetics reveals affinities of protein conformational states. 
  • Conformational selection or induced fit: a flux description of reaction mechanism. 
  • Conformationally averaged score functions for electronic propagation in proteins. 
  • Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation. 
  • Construction of a zebrafish cDNA microarray: gene expression profiling of the zebrafish during development. 
  • Contribution of a buried hydrogen bond to lambda repressor folding kinetics. 
  • Contribution of various carbon sources toward isoprene biosynthesis in poplar leaves mediated by altered atmospheric CO2 concentrations. 
  • Contributions of fat and protein to the incretin effect of a mixed meal. 
  • Control of Mesh Size and Modulus by Kinetically Dependent Cross-Linking in Hydrogels. 
  • Control of cholecystokinin receptor dephosphorylation in pancreatic acinar cells. 
  • Control of liver and brain aromatic amino-acid metabolism by phenylalanine hydroxylase. 
  • Control of phenylalanine hydroxylase synthesis in tissue culture by serum and insulin. 
  • Control of yeast mating signal transduction by a mammalian beta 2-adrenergic receptor and Gs alpha subunit. 
  • Controlled Multifactorial Coagulopathy: Effects of Dilution, Hypothermia, and Acidosis on Thrombin Generation In Vitro. 
  • Controlled release of simvastatin from in situ forming hydrogel triggers bone formation in MC3T3-E1 cells. 
  • Controlling the kinetics of thiol-maleimide Michael-type addition gelation kinetics for the generation of homogenous poly (ethylene glycol) hydrogels 
  • Conversion of Tyr361 beta to Leu in mammalian protein farnesyltransferase impairs product release but not substrate recognition. 
  • Conversion of a maltose receptor into a zinc biosensor by computational design. 
  • Cooperative activation of human factor IX by the human extrinsic pathway of blood coagulation. 
  • Cooperative interaction of divalent metal ions, substrate, and tissue factor with factor VIIa. 
  • Coordinate regulation of the proximal and distal steps of the pathway of purine synthesis de nono in WI-L2 human lymphoblasts. 
  • Coordinated posttranscriptional mRNA population dynamics during T-cell activation. 
  • Coordination chemistry of siderophores: thermodynamics and kinetics of iron chelation and release. 
  • Copper-dependent site-specific mutagenesis by benzoyl peroxide in the supF gene of the mutation reporter plasmid pS189. 
  • Correlation between axonal morphologies and synaptic input kinetics of interneurons from mouse visual cortex. 
  • Correlation of enzymatic activities and aggregation state in chicken liver fatty acid synthase. 
  • Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain. 
  • Cortical reorganization following fertilization of sea urchin eggs: sensitivity to cytochalasin B. 
  • Corticotropin-releasing factor inhibits gastric emptying in dogs. 
  • Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system. 
  • Coupling of the expressed alpha 1B-adrenergic receptor to the phospholipase C pathway in Xenopus oocytes. The role of Go. 
  • Covalent labeling of the cerebral cortex alpha 1-adrenergic receptor with a new high affinity radioiodinated photoaffinity probe. 
  • Creatine kinase overexpression improves ATP kinetics and contractile function in postischemic myocardium. 
  • Creatinine kinase kinetics studied by phosphorus-31 nuclear magnetic resonance in a canine model of chronic hypertension-induced cardiac hypertrophy. 
  • Critical appraisal of four IL-6 immunoassays. 
  • Crosstalk Between T and B Cells in the Germinal Center After Transplantation. 
  • Crystal structure of Streptococcus pyogenes sortase A: implications for sortase mechanism. 
  • Crystal structure of a photoactive yellow protein from a sensor histidine kinase: conformational variability and signal transduction. 
  • Crystal structure of a thermostable Bacillus DNA polymerase I large fragment at 2.1 A resolution. 
  • Culture kinetics of glycolytic enzyme induction, glucose utilization, and thymidine incorporation of extended-exposure phytohemagglutinin-stimulated human lymphocytes. 
  • Cultured glomerular mesangial cells contain renin: influence of calcium and isoproterenol. 
  • Cupric ion/ascorbate/hydrogen peroxide-induced DNA damage: DNA-bound copper ion primarily induces base modifications. 
  • Cutaneous herpes simplex virus infection of guinea pigs as a model for antiviral chemotherapy. 
  • Cutting edge: trimolecular interaction of TCR with MHC class II and bacterial superantigen shows a similar affinity to MHC:peptide ligands. 
  • Cyclic GMP modulates depletion-activated Ca2+ entry in pancreatic acinar cells. 
  • Cyclic adenosine 3':5'-monophosphate-dependent protein kinase. 
  • Cyclic phosphorylation-dephosphorylation of rhodopsin in retina by protein kinase FA (the activator of ATP.Mg-dependent protein phosphatase). 
  • Cyclooxygenase-1 and -2 knockout mice demonstrate increased cardiac ischemia/reperfusion injury but are protected by acute preconditioning. 
  • Cyclophilin active site mutants have native prolyl isomerase activity with a protein substrate. 
  • Cyclosporine increases hepatocyte synthesis of the immunosuppressive free radical nitric oxide. 
  • Cystine and lysine transport in cultured human renal epithelial cells. 
  • Cytochrome c oxidase binding of hydrogen peroxide. 
  • Cytosine deamination in mismatched base pairs. 
  • DNA breakage and closure by rat liver type 1 topoisomerase: separation of the half-reactions by using a single-stranded DNA substrate. 
  • DNA chain length dependence of formation and dynamics of hMutSalpha.hMutLalpha.heteroduplex complexes. 
  • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. 
  • DNA interstrand crosslinking and strand break repair in human glioma cell lines of varying [1,3-bis(2-chloroethyl)-1-nitrosourea] resistance. 
  • DNA polymerase zeta introduces multiple mutations when bypassing spontaneous DNA damage in Saccharomyces cerevisiae. 
  • DNA repair in human leukaemic lymphocytes. 
  • DNA repair synthesis in isolated rainbow trout liver cells. 
  • DNA-dependent activation of the hMutSalpha ATPase. 
  • De novo engineering of intracellular condensates using artificial disordered proteins. 
  • Deadly diving? Physiological and behavioural management of decompression stress in diving mammals. 
  • Decline of nucleotide excision repair capacity in aging Caenorhabditis elegans. 
  • Decreased DNA interstrand cross-linking and cytotoxicity induced in human brain tumor cells by 1,3-bis(2-chloroethyl)-1-nitrosourea after in vitro reaction with glutathione. 
  • Decreased fibrinolytic activity in porcine-to-primate cardiac xenotransplantation. 
  • Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice. 
  • Defining fibronectin's cell adhesion synergy site by site-directed mutagenesis. 
  • Definition of cytochrome c binding domains by chemical modification. Interaction of horse cytochrome c with beef sulfite oxidase and analysis of steady state kinetics. 
  • Definition of distinct compartments in polarized Madin-Darby canine kidney (MDCK) cells for membrane-volume sorting, polarized sorting and apical recycling. 
  • Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons. 
  • Degradation of nonylphenol ethoxylates in estuarine sediment under aerobic and anaerobic conditions 
  • Deletion and site-directed mutagenesis of the ATP-binding motif (P-loop) in the bifunctional murine ATP-sulfurylase/adenosine 5'-phosphosulfate kinase enzyme. 
  • Deletion of the carboxyl terminus of Tie2 enhances kinase activity, signaling, and function. Evidence for an autoinhibitory mechanism. 
  • Deletion-mutant epidermal growth factor receptor in human gliomas: effects of type II mutation on receptor function. 
  • Delineation of the signaling pathways involved in glucocorticoid-induced and spontaneous apoptosis of rat thymocytes. 
  • Delivery of antisense oligonucleotides using HPMA polymer: synthesis of A thiol polymer and its conjugation to water-soluble molecules. 
  • Delivery rate affects uptake of a fluorescent glucose analog in murine metastatic breast cancer. 
  • Delta 9-tetrahydrocannabinol suppression of prolactin secretion in the rat: lack of direct pituitary effect. 
  • Demonstration and characterization of specific binding sites for factor VIII/von Willebrand factor on human platelets. 
  • Demonstration of GABA/barbiturate-receptor-mediated chloride transport in rat brain synaptoneurosomes: a functional assay of GABA receptor-effector coupling. 
  • Demonstration of a chemotactic factor receptor on macrophages. 
  • Deorphaning the Macromolecular Targets of the Natural Anticancer Compound Doliculide. 
  • Deoxycholate induces the preferential hydrolysis of polyphosphoinositides by human platelet and rat corneal phospholipase C. 
  • Deoxyribonucleic acid ligase. A steady state kinetic analysis of the reaction catalyzed by the enzyme from Escherichia coli. 
  • Dephosphorylation of the beta 2-adrenergic receptor and rhodopsin by latent phosphatase 2. 
  • Depletion of arterial L-arginine causes reversible tolerance to endothelium-dependent relaxation. 
  • Deposition of aggregated nanoparticles--a theoretical and experimental study on the effect of aggregation state on the affinity between nanoparticles and a collector surface. 
  • Derivation and characterization of a simian immunodeficiency virus SIVmac239 variant with tropism for CXCR4. 
  • Desensitization of beta-adrenergic receptors by beta-adrenergic agonists in a cell-free system: resensitization by guanosine 5'-(beta, gamma-imino)triphosphate and other purine nucleotides. 
  • Design and Analysis of Localized DNA Hybridization Chain Reactions 
  • Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifungal activity. 
  • Design of a ruthenium-labeled cytochrome c derivative to study electron transfer with the cytochrome bc1 complex. 
  • Design, selection, and development of cyclic peptide ligands for human erythropoietin. 
  • Detailed analysis of cytomegalovirus (CMV)-specific T cells expanded for adoptive immunotherapy of CMV infection following allogeneic stem cell transplantation for malignant disease. 
  • Detailed mechanism of the autoxidation of N-hydroxyurea catalyzed by a superoxide dismutase mimic Mn(III) porphyrin: formation of the nitrosylated Mn(II) porphyrin as an intermediate. 
  • Detection of DNA looping due to simultaneous interaction of a DNA-binding protein with two spatially separated binding sites on DNA. 
  • Determination of L-lactate binding stoichiometry and differences in allosteric interactions of structurally distinct homohexamers from Panulirus interruptus hemocyanin. 
  • Determination of proliferation index in advanced ovarian cancer using quantitative image analysis. 
  • Determination of the functional status of alloreactive T cells by interferon-gamma kinetics. 
  • Determination of the significance of in vitro blast cell [3H]thymidine labelling indices obtained initially and serially during induction therapy of acute non-lymphocytic leukemia. 
  • Deubiquitinases and their emerging roles in β-arrestin-mediated signaling. 
  • Development and characterization of an Fv-1-sensitive retrovirus-packaging system: single-hit titration kinetics observed in restrictive cells. 
  • Development of a high-performance liquid chromatography assay and revision of kinetic parameters for the Staphylococcus aureus sortase transpeptidase SrtA. 
  • Development of dopamine neurotransmission and uptake inhibition in the caudate nucleus as measured by fast-cyclic voltammetry. 
  • Development of fast singing muscles in a katydid. 
  • Development of specific receptors for N-formylated chemotactic peptides in a human monocyte cell line stimulated with lymphokines. 
  • Developmental aspects of sugar transport by isolated dog renal cortical tubules. 
  • Developmental changes in the hormonal regulation of rat testis Sertoli cell adenylyl cyclase. 
  • Developmental changes of glycine transport in the dog. 
  • Developmental coordination of luteinizing hormone/human chorionic gonadotropin (hCG) receptors and acute hCG responsiveness in cultured and freshly harvested porcine granulosa cells. 
  • Developmental pattern of cystine transport in isolated rat renal tubules. 
  • Dialysate and blood flow dependence of diffusive solute clearance during CVVHD. 
  • Dietary accumulation and metabolism of polybrominated diphenyl ethers by juvenile carp (Cyprinus carpio). 
  • Differences between agonist and antagonist binding following beta-adrenergic receptor desensitization. 
  • Differences in brain cytochrome responses to carbon monoxide and cyanide in vivo. 
  • Differences in phosphorylation of formylpeptide and C5a chemoattractant receptors correlate with differences in desensitization. 
  • Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor. 
  • Different G(i)-coupled chemoattractant receptors signal qualitatively different functions in human neutrophils. 
  • Different dimerization activities of alpha and beta thyroid hormone receptor isoforms. 
  • Different oligomeric forms of protein phosphatase 2A activate and inhibit simian virus 40 DNA replication. 
  • Different sedimentation properties of agonist- and antagonist-labelled platelet alpha 2 adrenergic receptors. 
  • Differential anti-inflammatory effects of LPS in susceptible and resistant mouse strains. 
  • Differential cross-regulation of the human chemokine receptors CXCR1 and CXCR2. Evidence for time-dependent signal generation. 
  • Differential desensitization and phosphorylation of three cloned and transfected alpha 2-adrenergic receptor subtypes. 
  • Differential development of cholinergic nerve terminal markers in rat brain regions: implications for nerve terminal density, impulse activity and specific gene expression. 
  • Differential effects of GTP on the coupling of beta-adrenergic receptors to adenylate cyclase from frog and turkey erythrocytes. Application of new methods for the analysis of receptor-effector coupling. 
  • Differential effects of cholera toxin on guanine nucleotide regulation of beta-adrenergic agonist high affinity binding and adenylate cyclase activation in frog erythrocyte membranes. 
  • Differential effects of epidermal growth factor, somatomedin-C/insulin-like growth factor I, and transforming growth factor-beta on porcine granulosa cell deoxyribonucleic acid synthesis and cell proliferation. 
  • Differential expression of guanine nucleotide-binding proteins enhances cAMP synthesis in regenerating rat liver. 
  • Differential induction of mRNAs for the glycolytic and ethanolic fermentative pathways by hypoxia and anoxia in maize seedlings. 
  • Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor. 
  • Differential regulation of dopamine D1A receptor responsiveness by various G protein-coupled receptor kinases. 
  • Differential regulation of inducible nitric oxide synthase gene expression by ethanol in the human intestinal epithelial cell line DLD-1. 
  • Differential regulation of the alpha 2-adrenergic receptor by Na+ and guanine nucleotides. 
  • Differential secretion of proLHRH fragments in response to [K+], prostaglandin E2 and C kinase activation. 
  • Differential specificities and simultaneous occupancy of human MutSalpha nucleotide binding sites. 
  • Differential staining of actin in metaphase spindles with 7-nitrobenz-2-oxa-1,3-diazole-phallacidin and fluorescent DNase: is actin involved in chromosomal movement? 
  • Differential stimulation of the respiratory burst and lysosomal enzyme secretion in human polymorphonuclear leukocytes by synthetic diacylglycerols. 
  • Differentiation of normal marrow and HL60 cells induced by antithymocyte globulin. 
  • Diffusible factors are responsible for differences in nuclease sensitivity among chromatins originating from different cell types. 
  • Dihydroergocryptine binding and alpha-adrenoreceptors in smooth muscle. 
  • Dilution-induced disassembly of microtubules: relation to dynamic instability and the GTP cap. 
  • Dimerized Drosophila myosin VIIa: a processive motor. 
  • Direct allosteric regulation between the GAF domain and catalytic domain of photoreceptor phosphodiesterase PDE6. 
  • Direct evaluation of electronic coupling mediated by hydrogen bonds: implications for biological electron transfer. 
  • Direct identification and characterisation of beta-adrenergic receptors in rat brain. 
  • Direct in vivo measurement of targeted binding in a human tumor xenograft. 
  • Direct studies of beta-adrenergic receptors intact frog erythrocytes. 
  • Directed evolution of a new catalytic site in 2-keto-3-deoxy-6-phosphogluconate aldolase from Escherichia coli. 
  • Directed evolution of a pyruvate aldolase to recognize a long chain acyl substrate. 
  • Discovery and characterization of human antibody inhibitors of pregnancy-associated plasma protein-A. 
  • Discrete amino acid sequences of the alpha 1-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis. 
  • Disparity in the kinetics of onset of hypermutation in immunoglobulin heavy and light chains. 
  • Disruption of PF4/H multimolecular complex formation with a minimally anticoagulant heparin (ODSH). 
  • Disruption of myofibrillar energy use: dual mechanisms that may contribute to postischemic dysfunction in stunned myocardium. 
  • Dissecting the order of bacteriophage T4 DNA polymerase holoenzyme assembly. 
  • Dissociation kinetics of the GroEL-gp31 chaperonin complex studied with Förster resonance energy transfer. 
  • Dissociation of bacteriophage T4 DNA polymerase and its processivity clamp after completion of Okazaki fragment synthesis. 
  • Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs. 
  • Distance-independent charge recombination kinetics in cytochrome c-cytochrome c peroxidase complexes: compensating changes in the electronic coupling and reorganization energies. 
  • Distinct MutS DNA-binding modes that are differentially modulated by ATP binding and hydrolysis. 
  • Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation. 
  • Distinct specificity and single-molecule kinetics characterize the interaction of pathogenic and non-pathogenic antibodies against platelet factor 4-heparin complexes with platelet factor 4. 
  • Distribution kinetics of 3H--labeled p-phenylene diamine--a hair dye. 
  • Distribution of proteasomes and of the five proteolytic activities in rat tissues. 
  • Divalent cation activation of galactosyltransferase in native mammary Golgi vesicles. 
  • Divergent regulation of protein synthesis in the cytosol and endoplasmic reticulum compartments of mammalian cells. 
  • Does thalidomide affect IL-2 response and production? 
  • Domain unfolding plays a role in superfibronectin formation. 
  • Dominant kinetic paths on biomolecular binding-folding energy landscape. 
  • Donor specific bone marrow cells suppress lymphocyte reactivity to donor antigens and differentially modulate TH1 and TH2 cytokine gene expression in the responder cell population. 
  • Dopamine neuronal transport kinetics and effects of amphetamine. 
  • Dopaminergic behaviors and signal transduction mediated through adenylate cyclase and phospholipase C pathways. 
  • Dopaminergic receptors in the anterior pituitary gland. Correlation of [3H]dihydroergocryptine binding with the dopaminergic control of prolactin release. 
  • Down regulation of macrophage mannose/N-acetylglucosamine receptors by elevated glucose concentrations. 
  • Downhill kinetics of biomolecular interface binding: globally connected scenario. 
  • Drosophila RNA polymerase II mutants that affect transcription elongation. 
  • Drosophila melanogaster ma-l mutants are defective in the sulfuration of desulfo Mo hydroxylases. 
  • Drug reservoirs in topical therapy. 
  • Drug uptake and pharmacological modulation of drug sensitivity in leukemia by AQP9. 
  • Duplication of single stranded DNA catalyzed by calf thymus DNA polymerase alpha. 
  • Dynamic antibody-binding properties in the pathogenesis of HIT. 
  • Dynamic basis for dG•dT misincorporation via tautomerization and ionization. 
  • Dynamic docking and electron transfer between Zn-myoglobin and cytochrome b(5). 
  • Dynamic docking and electron-transfer between cytochrome b5 and a suite of myoglobin surface-charge mutants. Introduction of a functional-docking algorithm for protein-protein complexes. 
  • Dynamic instability of individual microtubules analyzed by video light microscopy: rate constants and transition frequencies. 
  • Dynamic interaction between a Drosophila transcription factor and RNA polymerase II. 
  • Dynamic perfluorinated gas MRI reveals abnormal ventilation despite normal FEV1 in cystic fibrosis. 
  • Dynamics and elasticity of the fibronectin matrix in living cell culture visualized by fibronectin-green fluorescent protein. 
  • ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system. 
  • Early differential elevation and persistence of phosphorylated cAMP-response element binding protein (p-CREB) in the central nervous system of hens treated with diisopropyl phosphorofluoridate, an OPIDN-causing compound. 
  • Eccentric exercise-induced muscle damage impairs muscle glycogen repletion. 
  • EcoRI endonuclease. Physical and catalytic properties of the homogenous enzyme. 
  • Effect of acidosis on glutamine transport by isolated rat renal brush-border and basolateral-membrane vesicles. 
  • Effect of alpha-isopropylmalate on the synthesis of RNA and protein in Neurospora. 
  • Effect of conformation on the binding of flavins to flavoenzymes. 
  • Effect of contact time and force on monocyte adhesion to vascular endothelium. 
  • Effect of cysteine residues on the activity of arginyl-tRNA synthetase from Escherichia coli. 
  • Effect of drug release kinetics on nanoparticle therapeutic efficacy and toxicity. 
  • Effect of famoxadone on photoinduced electron transfer between the iron-sulfur center and cytochrome c1 in the cytochrome bc1 complex. 
  • Effect of fasting and feeding on measurement of carbon dioxide production using doubly labeled water. 
  • Effect of hippocampal lesions produced by intracerebroventricular kainic acid on alcohol drinking in the rat. 
  • Effect of hyperthermia on cisplatin pharmacokinetics in normal dogs. 
  • Effect of hypophysectomy on somatostatin-14 and somatostatin-28 biosynthesis in the rat hypothalamus. 
  • Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis. 
  • Effect of intravenous alpha-difluoromethylornithine on the polyamine levels of normal tissue and a transplantable fibrosarcoma. 
  • Effect of oxygen and allosteric effects on structural stability of oligomeric hemocyanins of the arthropod, Limulus polyphemus, and the mollusc, Helix pomatia. 
  • Effect of pH and anions on functional properties of hemoglobin from Lemur fulvus fulvus. 
  • Effect of reduced inspired oxygen on fetal growth and maternal glucose metabolism in rat pregnancy. 
  • Effect of somatostatin-28 on dynamics of insulin secretion in perfused rat pancreas. 
  • Effect of steady illumination on the binding of carbon monoxide by carboxymethylated cytochrome c. 
  • Effect of temperature, pH, and metals on the stability and activity of phenylalanine hydroxylase from Chromobacterium violaceum. 
  • Effect of thrombolytic therapy on platelet expression and plasma concentration of PECAM-1 (CD31) in patients with acute myocardial infarction. 
  • Effect of type 1 transforming growth factor-beta on the level of aromatase cytochrome P-450 in human fetal hepatocytes. 
  • Effect of vitamin A on hepatic microsomal drug metabolising enzymes activity in rats exposed to acute hypoxia. 
  • Effective antibody therapy in herpes simplex virus ocular infection. Characterization of recipient immune response. 
  • Effects of (-)-trans- delta 9-tetrahydrocannabinol on serum prolactin in the pseudopregnant rat. 
  • Effects of GLP-1-(7-36)NH2, GLP-1-(7-37), and GLP-1- (9-36)NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humans. 
  • Effects of Natural Organic Matter Properties on the Dissolution Kinetics of Zinc Oxide Nanoparticles. 
  • Effects of a plasma-derived C1 esterase inhibitor on hemostatic activation, clot formation, and thrombin generation. 
  • Effects of amino acids and gastric inhibitory polypeptide on insulin release in dogs. 
  • Effects of ammonium ion derived from bovine endothelial cells upon low density lipoprotein degradation in cultured vascular smooth muscle cells. 
  • Effects of cyclic adenosine 3': 5'-monophosphate on phosphoprotein kinase and phosphatase fractions prepared from rat liver nuclei. 
  • Effects of droperidol on depolarization-induced automaticity, maximum upstroke velocity (Vmax) and the kinetics of recovery of Vmax in guinea-pig ventricular myocardium. 
  • Effects of estrogen on very low density lipoproteins (VLDL) synthesis in avian liver slices in vitro: lack of correlation with nuclear estrogen receptors. 
  • Effects of flavonoids on cytochrome P450-dependent acetaminophen metabolism in rats and human liver microsomes. 
  • Effects of glucagonlike peptide I-(7-36) on release of insulin, glucagon, and somatostatin by rat pancreatic islet cell monolayer cultures. 
  • Effects of heavy metals on the respiratory proteins of marine organisms in relation to environmental pollution. 
  • Effects of high-dose cancer chemotherapy on the absorption of digoxin in two different formulations. 
  • Effects of interleukin-3 on hematopoietic recovery after 5-fluorouracil or cyclophosphamide treatment of cynomolgus primates. 
  • Effects of methyl and inorganic mercury exposure on genome homeostasis and mitochondrial function in Caenorhabditis elegans. 
  • Effects of mutant Ran/TC4 proteins on cell cycle progression. 
  • Effects of mutational loss of adenosine kinase and deoxycytidine kinase on deoxyATP accumulation and deoxyadenosine toxicity in cultured CEM human T-lymphoblastoid cells. 
  • Effects of neurochemicals upon a dinoflagellate photoresponse. 
  • Effects of pimozide and penfluridol on the binding and endocytosis of alpha 2-macroglobulin-CH3NH2 by mouse peritoneal macrophages. 
  • Effects of recirculating flow on U-937 cell adhesion to human umbilical vein endothelial cells. 
  • Effects of sex and gonadectomy on cocaine metabolism in the rat. 
  • Effects of specific activity on meta-[(131)I]iodobenzylguanidine kinetics in isolated rat heart. 
  • Electron Bifurcation: Thermodynamics and Kinetics of Two-Electron Brokering in Biological Redox Chemistry. 
  • Electron acceptor function of O2 in radical N-demethylation reactions catalyzed by hemeproteins. 
  • Electron paramagnetic resonance and optical spectroscopic evidence for interaction between siroheme and Fe4S4 prosthetic groups in Escherichia coli sulfite reductase hemoprotein subunit. 
  • Electron paramagnetic resonance of the tungsten derivative of rat liver sulfite oxidase. 
  • Electron ratcheting in self-assembled soft matter. 
  • Electron-nuclear double resonance studies of oxidized Escherichia coli sulfite reductase: 1H, 14N, and 57Fe measurements. 
  • Electrophysiological and biochemical characteristics of Gymnodinium breve toxins. 
  • Electrostatic contribution in the catalysis of O2*- dismutation by superoxide dismutase mimics. MnIIITE-2-PyP5+ versus MnIIIBr8T-2-PyP+. 
  • Elementary steps in the reaction mechanism of chicken liver fatty acid synthase. Acylation of specific binding sites. 
  • Elementary steps in the reaction mechanism of chicken liver fatty acid synthase. pH dependence of NADPH binding and isotope rate effect for beta-ketoacyl reductase. 
  • Elementary steps in the reaction mechanism of chicken liver fatty acid synthase: acetylation-deacetylation. 
  • Elementary steps in the reaction mechanism of chicken liver fatty acid synthase: beta-ketoacyl reductase and enoyl reductase. 
  • Elementary steps in the reaction mechanism of chicken liver fatty acid synthase: reduced nicotinamide adenine dinucleotide phosphate binding and formation and reduction of acetoacetyl-enzyme. 
  • Elementary steps in the reaction mechanism of pyruvate dehydrogenase multienzyme complex from Escherichia coli: kinetics of flavin reduction. 
  • Elementary steps in the reaction mechanism of the alpha-ketoglutarate dehydrogenase multienzyme complex from Escherichia coli: kinetics of succinylation and desuccinylation. 
  • Elementary steps in the reaction mechanism of the pyruvate dehydrogenase multienzyme complex from Escherichia coli: kinetics of acetylation and deacetylation. 
  • Elevated beta-adrenergic receptor number after chronic propranolol treatment. 
  • Elevated chemokine responses are maintained in lungs after clearance of viral infection. 
  • Elevated plasma cholecystokinin and appetitive ratings after consumption of a liquid meal in humans. 
  • Elongation by Drosophila RNA polymerase II. Transcription of 3'-extended DNA templates. 
  • Elucidation of a [4Fe-4S] cluster degradation pathway: rapid kinetic studies of the degradation of Chromatium vinosum HiPIP. 
  • Emergence of limit-periodic order in tiling models. 
  • Emergent bistability by a growth-modulating positive feedback circuit. 
  • Enantiomeric metabolic interactions and stereoselective human methadone metabolism. 
  • End range eccentric antagonist/concentric agonist strength ratios: a new perspective in shoulder strength assessment. 
  • Endogenous polymers of ADP-ribose are associated with the nuclear matrix. 
  • Endogenous protein kinase-C activation in osteoblast-like cells modulates responsiveness to estrogen and estrogen receptor levels. 
  • Endotoxin-mediated synthesis of nitric oxide is dependent on Gq protein signal transduction. 
  • Energetic contribution of non-essential 5' sequence to catalysis in a hepatitis delta virus ribozyme. 
  • Energetics of lectin-carbohydrate binding. A microcalorimetric investigation of concanavalin A-oligomannoside complexation. 
  • Energy Transduction in Nitrogenase. 
  • Energy transfer assays of rat renal cortical endosomal fusion: evidence for superfusion. 
  • Engineering the substrate specificity of Staphylococcus aureus Sortase A. The beta6/beta7 loop from SrtB confers NPQTN recognition to SrtA. 
  • Enhanced cardiac function in transgenic mice expressing a Ca(2+)-stimulated adenylyl cyclase. 
  • Enhanced protein breakdown after eccentric exercise in young and older men. 
  • Enhanced receptor-cyclase coupling and augmented catecholamine-stimulated lipolysis in exercising rats. 
  • Enhanced uptake of a thermally responsive polypeptide by tumor cells in response to its hyperthermia-mediated phase transition. 
  • Enhancement of transport selectivity through nano-channels by non-specific competition. 
  • Enrichment of endogenous fractalkine and anti-inflammatory cells via aptamer-functionalized hydrogels. 
  • Enteral enhancement of glucose disposition by both insulin-dependent and insulin-independent processes. A physiological role of glucagon-like peptide I. 
  • Enzymatic joining of polynucleotides. IX. A simple and rapid assay of polynucleotide joining (ligase) activity by measurement of circle formation from linear deoxyadenylate-deoxythymidylate copolymer. 
  • Epidermal growth factor ligand-independent, unregulated, cell-transforming potential of a naturally occurring human mutant EGFRvIII gene. 
  • Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase. 
  • Escherichia coli dam methylase. Physical and catalytic properties of the homogeneous enzyme. 
  • Escherichia coli phage T4 topoisomerase. 
  • Escherichia coli sulfite reductase hemoprotein subunit. Prosthetic groups, catalytic parameters, and ligand complexes. 
  • Essential Ca(V)beta modulatory properties are AID-independent. 
  • Essential role of conserved arginine 160 in intramolecular electron transfer in human sulfite oxidase. 
  • Establishment of the DU.528 human lymphohemopoietic stem cell line. 
  • Estimating relative changes of metabolic fluxes. 
  • Estimation of D2-like receptor occupancy by dopamine in the putamen of hemiparkinsonian Monkeys. 
  • Estimation of in-canopy ammonia sources and sinks in a fertilized Zea mays field 
  • Estrogen stimulates the transient association of calmodulin and myosin light chain kinase with the chicken liver nuclear matrix. 
  • Estrogen-induced changes in translation, and specific messenger RNA levels during oviduct differentiation. 
  • Estrogen-induced synthesis of ovalbumin messenger RNA and its translation in a cell-free system. 
  • Ethanol inhibits spontaneous activity of central nucleus of the amygdala neurons but does not impair retention in the passive-avoidance task. 
  • Ethynodiol diacetate metabolites in human plasma. 
  • Evaluation of the DNA binding tendencies of the transition state regulator AbrB. 
  • Evaluation of the oxidation of organic compounds by aqueous suspensions of photosensitized hydroxylated-C60 fullerene aggregates. 
  • Evidence against formation of A23187 dimers and oligomers in solution: photo-induced degradation of Ionophore A23187. 
  • Evidence for a common mechanism of action for antitumor and antibacterial agents that inhibit type II DNA topoisomerases. 
  • Evidence for a low Km transporter for non-transferrin-bound iron in isolated rat hepatocytes. 
  • Evidence for a radical mechanism of halogenation of monochlorodimedone catalyzed by chloroperoxidase. 
  • Evidence for a role of chloroethylaziridine in the cytotoxicity of cyclophosphamide. 
  • Evidence for an alternative glycolytic pathway in rapidly proliferating cells. 
  • Evidence for metabolic and endocrine abnormalities in subjects recovered from anorexia nervosa. 
  • Evidence for selective release of rodent islet amyloid polypeptide through the constitutive secretory pathway. 
  • Evidence for the inorganic nature of the cyanolyzable sulfur of molybdenum hydroxylases. 
  • Evidence for the involvement of metalloendoproteases in the acrosome reaction in sea urchin sperm. 
  • Evidence for two cellular pathways of renin secretion by the mouse submandibular gland. 
  • Evidence that a beta-adrenergic receptor-associated guanine nucleotide regulatory protein conveys guanosine 5'-O-(3-thiotriphosphate)- dependent adenylate cyclase activity. 
  • Evidence that activation of acetyl-CoA carboxylase by insulin in adipocytes is mediated by a low-Mr effector and not by increased phosphorylation. 
  • Evidence that genomic and antigenomic RNA self-cleaving elements from hepatitis delta virus have similar secondary structures. 
  • Evidence that renal prostaglandin and thromboxane production is stimulated in chronic cyclosporine nephrotoxicity. 
  • Evidence that the platinum-reactive methionyl residue of the alpha 2-macroglobulin receptor recognition site is not in the carboxyl-terminal receptor binding domain. 
  • Evolution of flux control in the glucosinolate pathway in Arabidopsis thaliana 
  • Exchange of monooleoylphosphatidylcholine as monomer and micelle with membranes containing poly(ethylene glycol)-lipid. 
  • Experimental evidence for the secondary structure of the hepatitis delta virus ribozyme. 
  • Experimental validation of the docking orientation of Cdc25 with its Cdk2-CycA protein substrate. 
  • Experimentally Dissecting the Origins of Peroxiredoxin Catalysis. 
  • Expression analysis of the T-cell-targeting chemokines CXCL9 and CXCL10 in mice and humans with endothelial infections caused by rickettsiae of the spotted fever group. 
  • Expression and hormonal regulation of coactivator and corepressor genes. 
  • Expression and regulation of calcium-independent protein kinase C in NG 108-15 cell differentiation. 
  • Expression and site-directed mutagenesis of the phosphatidylcholine-preferring phospholipase C of Bacillus cereus: probing the role of the active site Glu146. 
  • Expression and subcellular distribution of mouse cytochrome P1-450 mRNA as determined by molecular hybridization with cloned P1-450 DNA. 
  • Expression of O6-alkylguanine-DNA alkyltransferase in Mer+ and Mer- human cell extracts probed with specific monoclonal antibodies. 
  • Expression of a peptide inhibitor of protein phosphatase 1 increases phosphorylation and activity of CREB in NIH 3T3 fibroblasts. 
  • Expression of cell cycle related proteins--proliferating cell nuclear antigen (PCNA) and statin--during adaptation and de-adaptation of EUE cells to a hypertonic medium. 
  • Expression of functional chicken oviduct progesterone receptors in yeast (Saccharomyces cerevisiae). 
  • Expression of glucokinase in cultured human muscle cells confers insulin-independent and glucose concentration-dependent increases in glucose disposal and storage. 
  • Expression of human malaria parasite purine nucleoside phosphorylase in host enzyme-deficient erythrocyte culture. Enzyme characterization and identification of novel inhibitors. 
  • Expression of recombinant human methylmalonyl-CoA mutase: in primary mut fibroblasts and Saccharomyces cerevisiae. 
  • Expression of type I and type II bovine scavenger receptors in Chinese hamster ovary cells: lipid droplet accumulation and nonreciprocal cross competition by acetylated and oxidized low density lipoprotein. 
  • Expression, subcellular localization, and enzyme activity of a recombinant human extra-cellular superoxide dismutase in tobacco (Nicotiana benthamiana L.). 
  • Extending the range of microsecond-to-millisecond chemical exchange detected in labeled and unlabeled nucleic acids by selective carbon R(1rho) NMR spectroscopy. 
  • Extensive hydrolysis of N-formyl-L-methionyl-L-leucyl-L-[3H] phenylalanine by human polymorphonuclear leukocytes. A potential mechanism for modulation of the chemoattractant signal. 
  • Extent of equilibrium perturbation of the DNA helix upon enzymatic methylation of adenine residues. 
  • Extracellular cAMP is sufficient to restore developmental gene expression and morphogenesis in Dictyostelium cells lacking the aggregation adenylyl cyclase (ACA). 
  • Extreme differences between hemoglobins I and II of the clam Lucina pectinalis in their reactions with nitrite. 
  • Extrinsic pathway proteolytic activity. 
  • FGF14 modulates resurgent sodium current in mouse cerebellar Purkinje neurons. 
  • FSH stimulation of protein kinase inhibitor: regulation of cellular metabolism. 
  • Facile chemical synthesis and equilibrium unfolding properties of CopG. 
  • Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B. 
  • Facilitated diffusion during catalysis by EcoRI endonuclease. Nonspecific interactions in EcoRI catalysis. 
  • Factor VIII/von Willebrand protein. Modification of its carbohydrate causes reduced binding to platelets. 
  • Factors IXa and Xa play distinct roles in tissue factor-dependent initiation of coagulation. 
  • Factors affecting Sertoli cell function in the testis. 
  • Factors that influence the uptake and turnover of glucocerebrosidase and alpha-galactosidase in mammalian liver. 
  • Farnesylation of nonpeptidic thiol compounds by protein farnesyltransferase. 
  • Fast and faster: a designed variant of the B-domain of protein A folds in 3 microsec. 
  • Fast and forceful refolding of stretched alpha-helical solenoid proteins. 
  • Fast and slow gating of sodium channels encoded by a single mRNA. 
  • Fatty acid synthase: elementary steps in catalysis and regulation. 
  • Fe(III) coordination properties of a new saccharide-based exocyclic trihydroxamate analogue of ferrichrome. 
  • Fibrinogen kinetics in patients with neoplastic disease. 
  • Fibrinolysis and fibrinogenolysis by Val442-plasmin. 
  • Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts. 
  • First report of urease activity in the novel systemic fungal pathogen Emergomyces africanus: a comparison with the neurotrope Cryptococcus neoformans. 
  • Fission yeast Cyk3p is a transglutaminase-like protein that participates in cytokinesis and cell morphogenesis. 
  • Flory theorem for structurally asymmetric mixtures 
  • Fluctuation-driven directional flow in biochemical cycle: further study of electric activation of Na,K pumps. 
  • Fluorescence energy transfer between ligand binding sites on aspartate transcarbamylase. 
  • Fluorescence energy transfer measurements in rabbit muscle phosphofructokinase. 
  • Fluorescence energy transfer measurements in the pyruvate dehydrogenase multienzyme complex from Escherichia coli with chemically modified lipoic acid. 
  • Fluorescence recovery kinetic analysis of gamma-tubulin binding to the mitotic spindle. 
  • Fluorescence studies of benzo-[a]-pyrene in liposome membrane systems. 
  • Fluorescence studies of chicken liver fatty acid synthase. Segmental flexibility and distance measurements. 
  • Fluorescence studies of the pyruvate dehydrogenase multienzyme complex from Escherichia coli. 
  • Fluorescent probes as indicators of conformation changes in transducin on activation. 
  • Fluorescent properties of pyrene bound at specific acylation sites of chicken liver fatty acid synthase. 
  • Fluorine-18 labeled chemotactic peptides: a potential approach for the PET imaging of bacterial infection. 
  • Fluorine-18-labeled [Nle4,D-Phe7]-alpha-MSH, an alpha-melanocyte stimulating hormone analogue. 
  • Folding kinetics of a fluorescent variant of monomeric lambda repressor. 
  • Follicle stimulating hormone regulation of protein kinase activity and protein synthesis in testis. 
  • Follicle-stimulating hormone activation of glycogen phosphorylase in the Sertoli cell-enriched rat testis. 
  • Follicle-stimulating hormone, the Sertoli cell, and spermatogenesis. 
  • Follicle-stimulating hormone-mediated induction of functional luteinizing hormone/human chorionic gonadotropin receptors during monolayer culture of porcine granulosa cells. 
  • Force-induced prolyl cis-trans isomerization in elastin-like polypeptides. 
  • Forelimb and hindlimb forces in walking and galloping primates. 
  • Formation and repair of 1,3-bis-(2-chloroethyl)-1-nitrosourea and cisplatin induced total genomic DNA interstrand crosslinks in human glioma cells. 
  • Formation of a free acyl adenylate during the activation of 2-propylpentanoic acid. Valproyl-AMP: a novel cellular metabolite of valproic acid. 
  • Formation of a rate-limiting intermediate in 5S RNA gene transcription. 
  • Formulation and characterisation of magnetic resonance imageable thermally sensitive liposomes for use with magnetic resonance-guided high intensity focused ultrasound. 
  • Free sphingosine formation from endogenous substrates by a liver plasma membrane system with a divalent cation dependence and a neutral pH optimum. 
  • From the Cover: mitotic gene conversion events induced in G1-synchronized yeast cells by gamma rays are similar to spontaneous conversion events. 
  • FtsZ filament dynamics at steady state: subunit exchange with and without nucleotide hydrolysis. 
  • Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. 
  • Function of tightly bound nucleotides on membrane-bound chloroplast coupling factor. 
  • Functional Class I and II Amino Acid-activating Enzymes Can Be Coded by Opposite Strands of the Same Gene. 
  • Functional and structural properties of Murex fulvescens hemocyanin: isolation of two different subunits required for reassociation of a molluscan hemocyanin. 
  • Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling. 
  • Functional asymmetry of transmembrane segments in nicotinic acetylcholine receptors. 
  • Functional characterization of medaka CYP3A38 and CYP3A40: kinetics and catalysis by expression in a recombinant baculovirus system. 
  • Functional consequences of ligand-linked dissociation in hemoglobin from the sea cucumber Molpadia arenicola. 
  • Functional consequences of truncating amino acid side chains located at a calmodulin-peptide interface. 
  • Functional differences in the multiple hemocyanins of the horseshoe crab, Limulus polyphemus L. 
  • Functional equivalence of monomeric (shark) and dimeric (bovine) cytochrome c oxidase. 
  • Functional evaluation of nonphagocytic NAD(P)H oxidases. 
  • Functional expression of human 5-HT1A receptors and differential coupling to second messengers in CHO cells. 
  • Functional expression of the multidrug resistance-associated protein in the yeast Saccharomyces cerevisiae. 
  • Functional inactivation and structural disruption of human alpha 2-macroglobulin by neutrophils and eosinophils. 
  • Functional interactions of recombinant alpha 2 adrenergic receptor subtypes and G proteins in reconstituted phospholipid vesicles. 
  • Functional properties of hemoglobin Pôrto Alegre (alpha2A beta2 9Ser leads to Cys) and the reactivity of its extra cysteinyl residue. 
  • Functional properties of normal and sickle cell hemoglobins in polyethylene glycol 6000. 
  • Functional properties of the hemoglobin from the South American snake Mastigodryas bifossatus. 
  • Functional roles of the two domains of phosducin and phosducin-like protein. 
  • Functional studies on crosslinked bovine cytochrome c oxidase. 
  • Functionally relevant gamma-aminobutyric acidA receptors: equivalence between receptor affinity (Kd) and potency (EC50)? 
  • Further characterization of nucleotide binding sites on chloroplast coupling factor one. 
  • Further insights into quinone cofactor biogenesis: probing the role of mauG in methylamine dehydrogenase tryptophan tryptophylquinone formation. 
  • G alpha t/G alpha i1 chimeras used to define structural basis of specific functions of G alpha t. 
  • G protein beta gamma subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of alpha subunits by pertussis toxin but differential interactions with Gs alpha. 
  • G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein. 
  • G protein-coupled receptor desensitization as a measure of signaling: modeling of arrestin recruitment to activated CCK-B receptors. 
  • G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity. 
  • G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer. 
  • G4 resolvase 1 binds both DNA and RNA tetramolecular quadruplex with high affinity and is the major source of tetramolecular quadruplex G4-DNA and G4-RNA resolving activity in HeLa cell lysates. 
  • GABAB-Receptor-mediated currents in interneurons of the dentate-hilus border. 
  • GBR12909 stimulates hypothalamo-pituitary-adrenal activity by inhibition of uptake at hypothalamic dopamine neurons. 
  • GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity. 
  • Ga3+ as a mechanistic probe in Fe3+ transport: characterization of Ga3+ interaction with FbpA. 
  • Gait kinetics of above- and below-branch quadrupedal locomotion in lemurid primates. 
  • Galactose and glucose metabolism in the isolated perfused suckling and adult rat liver. 
  • Gastric mucosal damage induced by 2-deoxy-D-glucose involves medullary TRH in the rat. 
  • Gender and limb differences in temporal gait parameters and gait variability in ankle osteoarthritis. 
  • Gene-expression profiling of the response of peripheral blood mononuclear cells and melanoma metastases to systemic IL-2 administration. 
  • Generation and characterization of circular Bacillus subtilis RNase P RNA; activation by RNase P protein. 
  • Generation of hydroxyl radical by crocidolite asbestos is proportional to surface [Fe3+]. 
  • Genetic analysis of susceptibility to Chlamydia trachomatis in mouse. 
  • Genetic and biochemical studies establish that the fungicidal effect of a fully depeptidized inhibitor of Cryptococcus neoformans myristoyl-CoA:protein N-myristoyltransferase (Nmt) is Nmt-dependent. 
  • Genetic control of peripheral leukocyte response to endotoxin in mice. 
  • Genetic diversity of coastal bottlenose dolphins revealed by structurally and functionally diverse hemoglobins. 
  • Genome-scale screen for DNA methylation-based detection markers for ovarian cancer. 
  • Genomic sequence and expression of a cloned human carbonyl reductase gene with daunorubicin reductase activity. 
  • Geranyl-geranyl acetone: a novel stimulant of secretin release in the dog. 
  • Global analysis of gene expression in renal ischemia-reperfusion in the mouse. 
  • Glu-111 is required for activation of the DNA cleavage center of EcoRI endonuclease. 
  • Glucagon stimulation of mitochondrial ATPase and potassium ion transport. 
  • Glucocorticoid-induced thymocyte apoptosis: protease-dependent activation of cell shrinkage and DNA degradation. 
  • Glucose down-regulates the expression of the peroxisome proliferator-activated receptor-alpha gene in the pancreatic beta -cell. 
  • Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival. 
  • Glutamate 350 Plays an Essential Role in Conformational Gating of Long-Range Radical Transport in Escherichia coli Class Ia Ribonucleotide Reductase. 
  • Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance. 
  • Glycine regulation of the N-methyl-D-aspartate receptor-gated ion channel in hippocampal membranes. 
  • Glycoprotein nonmetastatic melanoma protein B, a potential molecular therapeutic target in patients with glioblastoma multiforme. 
  • Gold(I)-catalyzed dynamic kinetic enantioselective intramolecular hydroamination of allenes. 
  • Gonadotropin release in patients with androgen insensitivity. Testicular feminization syndrome. 
  • Gout and the regulation of purine biosynthesis. 
  • Gradated assembly of multiple proteins into supramolecular nanomaterials. 
  • Granulocyte-angiotensin system. Identification of angiotensinogen as the plasma protein substrate of leukocyte cathepsin G. 
  • Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A. 
  • Graphene Enhances Actin Filament Assembly Kinetics and Modulates NIH-3T3 Fibroblast Cell Spreading. 
  • Growth Kinetics of Single Polymer Particles in Solution via Active-Feedback 3D Tracking. 
  • Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. 
  • Growth kinetics of human colorectal carcinoma. 
  • Growth rate of control and beta-interferon-treated human fibroblast populations over the course of their in vitro life span. 
  • Guanidine-induced equilibrium unfolding of a homo-hexameric enzyme 4-oxalocrotonate tautomerase (4-OT). 
  • Guanosine triphosphate binding sites in solubilized myocardium. Relation to adenylate cyclase activity. 
  • Guanosinetriphosphatase activity of tubulin associated with microtubule assembly. 
  • Guest exchange in an encapsulation complex: a supramolecular substitution reaction. 
  • Gz, a guanine nucleotide-binding protein with unique biochemical properties. 
  • H/D exchange- and mass spectrometry-based strategy for the thermodynamic analysis of protein-ligand binding. 
  • HDV ribozyme activity in monovalent cations. 
  • HPLC measurement, blood distribution, and pharmacokinetics of oral clotrimazole, potentially useful antisickling agent. 
  • Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. 
  • Haptoglobin alters oxygenation and oxidation of hemoglobin and decreases propagation of peroxide-induced oxidative reactions. 
  • HeLa cells express cAMP-inhibitable sodium-dependent phosphate uptake. 
  • Heat and cold denatured states of monomeric lambda repressor are thermodynamically and conformationally equivalent. 
  • Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide. 
  • Hemocyanin of the chambered nautilus: structure-function relationships. 
  • Hemocyanins in spiders, XIII. Kinetics of oxygen dissociation from individual subunits of Eurypelma and Cupiennius hemocyanin. 
  • Hemoglobin Abruzzo (beta143 (H21) His replaced by Arg). Consequences of altering the 2,3-diphosphoglycerate binding site. 
  • Hemoglobin Deer Lodge (beta 2 His replaced by Arg). Consequences of altering the 2,3-diphosphoglycerate binding site. 
  • Hemoglobin Raleigh (beta1 valine replaced by acetylalanine). Structural and functional characterization. 
  • Hemoglobin of the electric Atlantic torpedo, Torpedo nobiliana: a cooperative hemoglobin without Bohr effects. 
  • Hemoglobin switching in sheep. Cloning and characterization of the beta A and beta-like embryonic globin genes from genomic DNA. 
  • Hemoglobins from trout: structural and functional properties. 
  • Hemoglobins of the tadpole of the bullfrog, Rana catesbeiana. pH dependence of ligand binding and subunit dissociation equilibria and kinetics. 
  • Heparin oligosaccharides enhance tissue-type plasminogen activator: a correlation between oligosaccharide length and stimulation of plasminogen activation. 
  • Hepatic alpha-adrenergic receptors. Identification and subcellular localization using [3H]dihydroergocryptine. 
  • Hepatic cyclic AMP generation and ornithine decarboxylase induction by glucagon and beta adrenergic agonists. 
  • Hepatic sulfite oxidase. Effect of anions on interaction with cytochrome c. 
  • Hepatic sulfite oxidase. Identification of the molybdenum center as the site of irreversible inactivation by ferricyanide. 
  • Hepatocyte receptors for antithrombin III-proteinase complexes. 
  • Heterogeneity and probabilistic binding contributions to receptor-mediated cell detachment kinetics. 
  • Heterogeneity of radioligand binding to alpha-adrenergic receptors. Analysis of guanine nucleotide regulation of agonist binding in relation to receptor subtypes. 
  • Heterologous desensitization of the inhibitory A1 adenosine receptor-adenylate cyclase system in rat adipocytes. Regulation of both Ns and Ni. 
  • Hierarchy of RNA functional dynamics. 
  • High affinity binding of [3H]epibatidine to rat brain membranes. 
  • High level expression of mammalian protein farnesyltransferase in a baculovirus system. The purified protein contains zinc. 
  • High potency silencing by single-stranded boranophosphate siRNA. 
  • High-Molecular-Weight Polynucleotides by Transferase-Catalyzed Living Chain-Growth Polycondensation. 
  • High-affinity binding of [3H]acetylcholine to muscarinic cholinergic receptors. 
  • High-level expression and single-step purification of leucyl-tRNA synthetase from Escherichia coli. 
  • High-performance liquid chromatography of haloperidol in serum at the concentrations achieved during chronic therapy. 
  • High-resolution analytical electron microscopy reveals cell culture media-induced changes to the chemistry of silver nanowires. 
  • High-throughput affinity ranking of antibodies using surface plasmon resonance microarrays. 
  • Homeostatic mechanisms in dopamine synthesis and release: a mathematical model. 
  • Homeostatic regulation of airway smooth muscle tone by catecholamine secretion in swine. 
  • Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2. 
  • Homocystine uptake in isolated rat renal cortical tubules. 
  • Hormonal control of angiotensinogen production. 
  • Hormonal inhibition of adenylate cyclase. alpha 2 Adrenergic receptors promote release of [3H]guanylylimidodiphosphate from platelet membranes. 
  • Hormonal regulation of androgen-binding protein in hypophysectomized rats. 
  • Hormone receptor complexes and their modulation of membrane function. 
  • Hostility and minimal model of glucose kinetics in African American women. 
  • How do enzymes really work? 
  • How spike generation mechanisms determine the neuronal response to fluctuating inputs. 
  • How the kinetochore couples microtubule force and centromere stretch to move chromosomes. 
  • Human IFN-gamma production is inhibited by a synthetic peptide homologous to retroviral envelope protein. 
  • Human IL-1 beta processing and secretion in recombinant baculovirus-infected Sf9 cells is blocked by the cowpox virus serpin crmA. 
  • Human cardiac beta-adrenergic receptors: subtype heterogeneity delineated by direct radioligand binding. 
  • Human endometrial epithelial cells cyclically express Toll-like receptor 3 (TLR3) and exhibit TLR3-dependent responses to dsRNA. 
  • Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine. 
  • Human immunodeficiency virus type 1 gp41 antibodies that mask membrane proximal region epitopes: antibody binding kinetics, induction, and potential for regulation in acute infection. 
  • Human leukemia cell lines with comparable receptor binding characteristics but different phenotypic responses to phorbol diesters. 
  • Human melanoma-mediated inhibition of autologous CD4+ helper tumor-infiltrating lymphocyte growth in vitro. 
  • Human mitochondrial DNA polymerase gamma exhibits potential for bypass and mutagenesis at UV-induced cyclobutane thymine dimers 
  • Human platelet-derived growth factor preparations contain a separate activity which potentiates follicle-stimulating hormone-mediated induction of luteinizing hormone receptor in cultured rat granulosa cells: evidence for transforming growth factor-beta. 
  • Human reductive halothane metabolism in vitro is catalyzed by cytochrome P450 2A6 and 3A4. 
  • Human skin chymotrypsin-like proteinase chymase. Subcellular localization to mast cell granules and interaction with heparin and other glycosaminoglycans. 
  • Human skin chymotryptic proteinase. Isolation and relation to cathepsin g and rat mast cell proteinase I. 
  • Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reaction. 
  • Human substance P receptor undergoes agonist-dependent phosphorylation by G protein-coupled receptor kinase 5 in vitro. 
  • Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung. 
  • Humoral Immune Reconstitution Kinetics after Allogeneic Hematopoietic Stem Cell Transplantation in Children: A Maturation Block of IgM Memory B Cells May Lead to Impaired Antibody Immune Reconstitution. 
  • Hydrolysis of N3-methyl-2'-deoxycytidine: model compound for reactivity of protonated cytosine residues in DNA. 
  • Hydrolysis of template and newly synthesized deoxyribonucleic acid by the 3' to 5' exonuclease activity of the T4 deoxyribonucleic acid polymerase. 
  • Hydroxytyrosol, a natural molecule occurring in olive oil, induces cytochrome c-dependent apoptosis. 
  • Hyperreactive platelet phenotypes: relationship to altered serotonin transporter number, transport kinetics and intrinsic response to adrenergic co-stimulation. 
  • Hypothermia: role of alpha 1- and alpha 2-noradrenergic receptors in the hypothalamus of the cat. 
  • Hypothermic reperfusion after cardiac arrest augments brain-derived neurotrophic factor activation. 
  • Hypoxanthine uptake in isolated rat renal cortical tubule fragments. 
  • IL-7 enhances the survival and maintains the size of naive T cells. 
  • Identification and biochemical studies on novel non-nucleoside inhibitors of the enzyme adenosine kinase. 
  • Identification and characterization of a new cross-reactive human immunodeficiency virus type 1-neutralizing human monoclonal antibody. 
  • Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases. 
  • Identification and characterization of the enzymatic activity of zeta-crystallin from guinea pig lens. A novel NADPH:quinone oxidoreductase. 
  • Identification and characterization of the sodium-binding site of activated protein C. 
  • Identification and characterization of two Ca2+/CaM-dependent protein kinases required for normal nuclear division in Aspergillus nidulans. 
  • Identification and partial purification of ankyrin, the high affinity membrane attachment site for human erythrocyte spectrin. 
  • Identification and regulation of beta-adrenergic receptors. 
  • Identification of "embryonin" as bovine alpha 2-macroglobulin. 
  • Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-zeta inhibitors and potential therapeutics for psychostimulant abuse. 
  • Identification of a cysteine residue essential for activity of protein farnesyltransferase. Cys299 is exposed only upon removal of zinc from the enzyme. 
  • Identification of a negative regulatory function for steroid receptors. 
  • Identification of a new subclass of Alu DNA repeats which can function as estrogen receptor-dependent transcriptional enhancers. 
  • Identification of a nonbasic, nitrile-containing cathepsin K inhibitor (MK-1256) that is efficacious in a monkey model of osteoporosis. 
  • Identification of a novel malonyl-CoA IC(50) for CPT-I: implications for predicting in vivo fatty acid oxidation rates. 
  • Identification of adenylate cyclase-coupled beta-adrenergic receptors with radiolabeled beta-adrenergic antagonists. 
  • Identification of alpha-adrenergic receptors in human platelets by [3H]dihydroergocryptine binding. 
  • Identification of alpha-adrenergic receptors in uterine smooth muscle membranes by [3H]dihydroergocryptine binding. 
  • Identification of amino acid residues involved in structural and ubiquinone-binding functions of subunit IV of the cytochrome bc1 complex from Rhodobacter sphaeroides. 
  • Identification of amino acids essential for calmodulin binding and activation of smooth muscle myosin light chain kinase. 
  • Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate. 
  • Identification of cardiac beta-adrenergic receptors by (minus) [3H]alprenolol binding. 
  • Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane. 
  • Identification of envelope V3 loop as the major determinant of CD4 neutralization sensitivity of HIV-1. 
  • Identification of functional regions on the tail of Acanthamoeba myosin-II using recombinant fusion proteins. I. High resolution epitope mapping and characterization of monoclonal antibody binding sites. 
  • Identification of key amino acids responsible for the substantially higher affinities of human type 1 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD1) for substrates, coenzymes, and inhibitors relative to human 3beta-HSD2. 
  • Identification of protein phosphatase-1-binding proteins by microcystin-biotin affinity chromatography. 
  • Identification of rat yolk sac target protein of teratogenic antibodies, gp280, as intrinsic factor-cobalamin receptor. 
  • Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation. 
  • Identification of substrate specificity determinants for the cell cycle-regulated NIMA protein kinase. 
  • Identification of the human NHE-1 form of Na(+)-H+ exchanger in rabbit renal brush border membranes. 
  • Identification of the iron-sulfur center of spinach ferredoxin-nitrite reductase as a tetranuclear center, and preliminary EPR studies of mechanism. 
  • Identification of the subunit-binding site of alpha 2-adrenergic receptors using [3H]phenoxybenzamine. 
  • Identification of the yeast cytidine deaminase CDD1 as an orphan C-->U RNA editase. 
  • Identification, partial purification, and characterization of a novel phospholipid-dependent and fatty acid-activated protein kinase from human platelets. 
  • Imaging-Based Reporter Systems to Define CVB-Induced Membrane Remodeling in Living Cells. 
  • Immature human thymocytes can be driven to differentiate into nonlymphoid lineages by cytokines from thymic epithelial cells. 
  • Immune (gamma) interferon production by a murine T cell lymphoma: requirements for macromolecular synthesis and lack of relationship with cell cycle. 
  • Immune-related intestinal chloride secretion. II. Effect of adenosine on T84 cell line. 
  • Immunoglobulin-like PapD chaperone caps and uncaps interactive surfaces of nascently translocated pilus subunits. 
  • Impact of 25-hydroxyvitamin D deficiency on perioperative parathyroid hormone kinetics and results in patients with primary hyperparathyroidism. 
  • Importance of voltage-dependent inactivation in N-type calcium channel regulation by G-proteins. 
  • Improved killing of HIV-infected cells using three neutralizing and non-neutralizing antibodies. 
  • In Vitro Comparison of a Novel Single Probe Dual-Energy Lithotripter to Current Devices. 
  • In Vivo Determination of Mitochondrial Function Using Luciferase-Expressing Caenorhabditis elegans: Contribution of Oxidative Phosphorylation, Glycolysis, and Fatty Acid Oxidation to Toxicant-Induced Dysfunction. 
  • In situ cross-linking of elastin-like polypeptide block copolymers for tissue repair. 
  • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells. 
  • In vitro binding and in vivo clearance of human alpha 2-macroglobulin after reaction with endoproteases from four different classes. 
  • In vitro characterization of vascular endothelial growth factor and dexamethasone releasing hydrogels for implantable probe coatings. 
  • In vitro hepatic metabolism explains higher clearance of voriconazole in children versus adults: role of CYP2C19 and flavin-containing monooxygenase 3. 
  • In vitro incorporation of nascent molybdenum cofactor into human sulfite oxidase. 
  • In vitro inhibition of chick embryo lysyl hydroxylase by homogentisic acid. A proposed connective tissue defect in alkaptonuria. 
  • In vitro inhibition of microsomal calcium atpase from eggshell gland of mallard duck. 
  • In vitro kinetics of immunoglobulin synthesis and secretion by nonsecretory human myeloma cells. 
  • In vitro metabolism of cyclosporine A by human kidney CYP3A5. 
  • In vitro metabolism of the brominated flame retardants 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (TBB) and bis(2-ethylhexyl) 2,3,4,5-tetrabromophthalate (TBPH) in human and rat tissues. 
  • In vitro neurogenesis by neuronal precursor cells derived from the adult songbird brain. 
  • In vivo dendritic cell tracking using fluorescence lifetime imaging and near-infrared-emissive polymersomes. 
  • In vivo inactivation of erythrocyte S-adenosylhomocysteine hydrolase by 2'-deoxyadenosine in adenosine deaminase-deficient patients. 
  • In vivo modulation of 17 beta-estradiol-induced vitellogenin synthesis and estrogen receptor in rainbow trout (Oncorhynchus mykiss) liver cells by beta-naphthoflavone. 
  • In vivo selection of tumor-targeting RNA motifs. 
  • In-vitro evaluation of anti-factor IXa aptamer on thrombin generation, clotting time, and viscoelastometry. 
  • Inactivation Kinetics and Mechanical Gating of Piezo1 Ion Channels Depend on Subdomains within the Cap. 
  • Inactivation of 4-oxalocrotonate tautomerase by 2-oxo-3-pentynoate. 
  • Inactivation of the plasma protease inhibitor alpha 2-macroglobulin by the antitumor drug cis-dichlorodiamineplatinum(II). 
  • Inactivation of the sodium current in squid giant axons by hydrocarbons. 
  • Incorporation of (alpha-P-borano)-2',3'-dideoxycytidine 5'-triphosphate into DNA by drug-resistant MMLV reverse transcriptase and Taq DNA polymerase. 
  • Incorporation of tyrosine and glutamine residues into the soluble guanylate cyclase heme distal pocket alters NO and O2 binding. 
  • Increased Ca2+ -ATPase activity associated with methylation of phospholipids in human erythrocytes. 
  • Increased adhesion between neutral lipid bilayers: interbilayer bridges formed by tannic acid. 
  • Increased envelope spike density and stability are not required for the neutralization resistance of primary human immunodeficiency viruses. 
  • Increased hypothalamic [3H]flunitrazepam binding in hypothalamic-pituitary-adrenal axis hyporesponsive Lewis rats. 
  • Increased rates of genomic deletions generated by mutations in the yeast gene encoding DNA polymerase delta or by decreases in the cellular levels of DNA polymerase delta. 
  • Increases in nitrogen uptake rather than nitrogen-use efficiency support higher rates of temperate forest productivity under elevated CO2. 
  • Increases in serum sphingosine and sphinganine and decreases in complex sphingolipids in ponies given feed containing fumonisins, mycotoxins produced by Fusarium moniliforme. 
  • Increasing the intracellular Na+ concentration induces differentiation in a pre-B lymphocyte cell line. 
  • Increasing uptake and bioactivation with development positively modulate diazinon toxicity in early life stage medaka (Oryzias latipes). 
  • Indirect and direct inhibition of dopamine beta-hydroxylase by amphetamine in storage vesicles and synaptosomes. 
  • Individual blood pressure responses to changes in salt intake: results from the DASH-Sodium trial. 
  • Induction of a cellular enzyme for energy metabolism by transforming domains of adenovirus E1a. 
  • Induction of anti-double stranded DNA antibodies in normal mice by immunization with bacterial DNA. 
  • Induction of c-fos mRNA expression by afterdischarge in the hippocampus of naive and kindled rats. 
  • Induction of cytochrome P(1)450 RNA and benzo[a]pyrene metabolism in primary human hepatocyte cultures with benzanthracene. 
  • Induction of ferritin and heme oxygenase-1 by endotoxin in the lung. 
  • Induction of interleukin-6 mRNA in rat alveolar macrophages by in vitro exposure to both Cryptococcus neoformans and anti-C. neoformans antiserum. 
  • Induction of micronuclei by X-radiation in human, mouse and rat peripheral blood lymphocytes. 
  • Induction of rat kidney ornithine decarboxylase by nicotinamide without a concomitant increase in DNA synthesis. 
  • Induction of superoxide anion and nitric oxide production in cultured microglia. 
  • Induction of tenascin in rat lungs undergoing bleomycin-induced pulmonary fibrosis. 
  • Infant cardiopulmonary bypass: CD73 kinetics, association with clinical outcomes, and influence on serum adenosine production capacity. 
  • Influence of Arginines 93, 97, and 101 of thrombin to its functional specificity. 
  • Influence of apolipoprotein E on soluble and heparin-immobilized hepatic lipase. 
  • Influence of buffers on dV/dtmax recovery kinetics with lidocaine in myocardium. 
  • Influence of dissolved organic matter on the environmental fate of metals, nanoparticles, and colloids 
  • Influence of natural organic matter on transport and retention of polymer coated silver nanoparticles in porous media. 
  • Influence of pulling handles and device stiffness in single-molecule force spectroscopy. 
  • Inhibiting the intrinsic pathway of coagulation with a factor XII-targeting RNA aptamer. 
  • Inhibition of 125I-chemotactic peptide uptake by protease inhibitors. 
  • Inhibition of DNA helicase II unwinding and ATPase activities by DNA-interacting ligands. Kinetics and specificity. 
  • Inhibition of G protein-coupled receptor signaling by expression of cytoplasmic domains of the receptor. 
  • Inhibition of acanthamoeba actomyosin-II ATPase activity and mechanochemical function by specific monoclonal antibodies. 
  • Inhibition of adenylosuccinate lyase by L-alanosyl-5-aminoimidazole-4-carboxylic acid ribonucleotide (alanosyl-AICOR). 
  • Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors. 
  • Inhibition of human natural killer cell activity by a synthetic peptide homologous to a conserved region in the retroviral protein, p15E. 
  • Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition. 
  • Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli. 
  • Inhibition of lysyl hydroxylase by catechol analogs. 
  • Inhibition of protein kinase C by a peptide conjugate homologous to a domain of the retroviral protein p15E. 
  • Inhibition of protein synthesis also inhibits synthesis of lipid-linked oligosaccharides. 
  • Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides. 
  • Inhibition of the Staphylococcus aureus sortase transpeptidase SrtA by phosphinic peptidomimetics. 
  • Inhibition of the beta-adrenergic receptor kinase by polyanions. 
  • Inhibition of the proton-translocating adenosine triphosphatase from chromatophores of photosynthetic bacteria by free bivalent cations and adenosine triphosphate [proceedings]. 
  • Inhibition of thyroid hormone sulfotransferase activity by brominated flame retardants and halogenated phenolics. 
  • Inhibition of tumor necrosis factor release from cultured rat Kupffer cells by agents that reduce graft failure from storage injury. 
  • Inhibitory effects of a phage-derived peptide on Au nanocrystal nucleation and growth. 
  • Initial B-cell responses to transmitted human immunodeficiency virus type 1: virion-binding immunoglobulin M (IgM) and IgG antibodies followed by plasma anti-gp41 antibodies with ineffective control of initial viremia. 
  • Innate-like Gene Expression of Lung-Resident Memory CD8+ T Cells during Experimental Human Influenza: A Clinical Study. 
  • Inositol 1,4,5-trisphosphate receptor localization and stability in neonatal cardiomyocytes requires interaction with ankyrin-B. 
  • Insights into the Autoproteolytic Processing and Catalytic Mechanism of the Chlamydia trachomatis Virulence-Associated Protease CPAF. 
  • Insulin activates a novel adipocyte mitogen-activated protein kinase kinase kinase that shows rapid phasic kinetics and is distinct from c-Raf. 
  • Insulin and phorbol ester stimulate phosphorylation of acetyl-CoA carboxylase at similar sites in isolated adipocytes. Lack of correspondence with sites phosphorylated on the purified enzyme by protein kinase C. 
  • Insulin-like growth factor-I is a serum component stimulating growth of human neuroblastoma. 
  • Intact negative feedback of four cardiac hormones in congestive heart failure. 
  • Interaction of aspartate transcarbamylase with 5-bromocytidine 5'-tri-, di-, and monophosphates. 
  • Interaction of atrial natriuretic polypeptide and angiotensin II on protooncogene expression and vascular cell growth. 
  • Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics. 
  • Interaction of nucleotides with chloroplast coupling factor 1. 
  • Interaction of photoreactive and fluorescent nucleotides with chloroplast coupling factor 1. 
  • Interaction of reduced nicotinamide adenine dinucleotide with beef heart s-malate dehydrogenase. 
  • Interaction of spin-labeled nicotinamide adenine dinucleotide phosphate with chicken liver fatty acid synthase. 
  • Interactions between nucleotide binding sites on chloroplast coupling factor during ATP hydrolysis. 
  • Interactions of agonists with platelet alpha 2-adrenergic receptors. 
  • Interconversion of two kinetically distinct states of the membrane-bound and solubilised H+-translocating ATPase from Rhodospirillum rubrum. 
  • Interfacial phase transition of an environmentally responsive elastin biopolymer adsorbed on functionalized gold nanoparticles studied by colloidal surface plasmon resonance. 
  • Interferon production in mixed cultures of murine leukocytes and syngeneic L1210 leukemia cells. 
  • Interferon regulatory factor-1 up-regulates angiotensin II type 2 receptor and induces apoptosis. 
  • Interindividual variation in human visual performance. 
  • Interleukin-1 beta decreases acetylcholine measured by microdialysis in the hippocampus of freely moving rats. 
  • Internal electron transfer between hemes and Cu(II) bound at cysteine beta93 promotes methemoglobin reduction by carbon monoxide. 
  • Interpreting properties of microbicide drug delivery gels: analyzing deployment kinetics due to squeezing. 
  • Intersubunit cross-linking by cis-dichlorodiammineplatinum(II) stabilizes an alpha 2-macroglobulin "nascent" state: evidence that thiol ester bond cleavage correlates with receptor recognition site exposure. 
  • Intraprotein electron transfer in inducible nitric oxide synthase holoenzyme. 
  • Intrasteric regulation of myosin light chain kinase: the pseudosubstrate prototope binds to the active site. 
  • Intraventricular CCK inhibits food intake and gastric emptying in baboons. 
  • Introduction of the alpha-P-borano-group into deoxynucleoside triphosphates increases their selectivity to HIV-1 reverse transcriptase relative to DNA polymerases. 
  • Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH. 
  • Investigation of quercetin binding sites on chloroplast coupling factor 1. 
  • Involvement of a cytosine side chain in proton transfer in the rate-determining step of ribozyme self-cleavage. 
  • Involvement of outside DNA sequences in the major kinetic path by which EcoRI endonuclease locates and leaves its recognition sequence. 
  • Involvement of radical species in the oxidation of aminopyrine and 4-aminoantipyrine by cumene hydroperoxide in rat liver microsomes. 
  • Involvement of the distal histidine in the low affinity exhibited by Hb Chico (Lys beta 66----Thr) and its isolated beta chains. 
  • Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor. 
  • Ionic basis of phenytoin sodium inhibition of insulin secretion in pancreatic islets. 
  • Ionic modulation of the effects of heparin on plasminogen activation by tissue plasminogen activator: the effects of ionic strength, divalent cations, and chloride. 
  • Ionophore 4-BrA23187 transports Zn2+ and Mn2+ with high selectivity over Ca2+. 
  • Iron chelation properties of an extracellular siderophore exochelin MN. 
  • Irreversible activation of adenylate cyclase of toad erythrocyte plasma membrane by 5'-guanylylimidodiphosphate. 
  • Isolation and characterization of a prenylcysteine lyase from bovine brain. 
  • Isolation and characterization of the beta-adrenergic receptor of frog erythrocytes and development of potential affinity ligands. 
  • Isolation and heterologous expression of a cDNA encoding bovine inositol polyphosphate 1-phosphatase. 
  • Isolation and properties of beta-glucosidase from Ruminococcus albus. 
  • Isolation of a human anti-HIV gp41 membrane proximal region neutralizing antibody by antigen-specific single B cell sorting. 
  • Isolation of novel EGFR-specific VHH domains. 
  • Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification. 
  • Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase. 
  • K channel gating by an affinity-switching selectivity filter. 
  • K channel subconductance levels result from heteromeric pore conformations. 
  • KRAX is important operational determinant of tissue response. KRAX as parameter for classification. 
  • Kainate and quisqualate receptor autoradiography in rat brain after angular bundle kindling. 
  • Key mutations stabilize antigen-binding conformation during affinity maturation of a broadly neutralizing influenza antibody lineage. 
  • Kindling reduces sensitivity of CA3 hippocampal pyramidal cells to competitive NMDA receptor antagonists. 
  • Kinematic characterization of standing reach: comparison of younger vs. older subjects. 
  • Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2. 
  • Kinetic analysis of the effects of glycosaminoglycans and lipoproteins on urokinase-mediated plasminogen activation. 
  • Kinetic analysis of the effects of heparin and lipoproteins on tissue plasminogen activator mediated plasminogen activation. 
  • Kinetic analysis of the zinc-dependent deacetylase in the lipid A biosynthetic pathway. 
  • Kinetic analysis of zinc ligand mutants of mammalian protein farnesyltransferase. 
  • Kinetic and equilibrium studies of the ribonuclease-catalyzed hydrolysis of uridine 2',3'-cyclic phosphate. 
  • Kinetic and nuclear magnetic resonance study of the interaction of NADP+ and NADPH with chicken liver fatty acid synthase. 
  • Kinetic and structural investigation of acyl-binding sites on avian fatty acid synthase. 
  • Kinetic characterization of Salmonella FliK-FlhB interactions demonstrates complexity of the Type III secretion substrate-specificity switch. 
  • Kinetic mechanism of RGS9-1 potentiation by R9AP. 
  • Kinetic mechanism of adenine phosphoribosyltransferase from Leishmania donovani. 
  • Kinetic mechanism of quinone oxidoreductase 2 and its inhibition by the antimalarial quinolines. 
  • Kinetic mechanism of the DNA-dependent DNA polymerase activity of human immunodeficiency virus reverse transcriptase. 
  • Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiation. 
  • Kinetic properties of iodinated ribonuclease A. 
  • Kinetic role of helix caps in protein folding is context-dependent. 
  • Kinetic scheme for intermolecular RNA cleavage by a ribozyme derived from hepatitis delta virus RNA. 
  • Kinetic studies of hydrogen bonding. 1-Cyclohexyluracil and 9-ethyladenine. 
  • Kinetic studies of protein farnesyltransferase mutants establish active substrate conformation. 
  • Kinetic studies of tryptophan synthetase. Interaction of L-serine, indole, and tryptophan with the native enzyme. 
  • Kinetic studies of tryptophan synthetase. Interaction of substrates with the B subunit. 
  • Kinetic study of collagen fixation with polyepoxy fixatives. 
  • Kinetic study of paracetamol on prolidase activity in erythrocytes by capillary electrophoresis with Ru(bpy)(3) (2+) electrochemiluminescence detection. 
  • Kinetic study of prolidase activity in erythrocytes against different substrates using capillary electrophoresis with electrochemiluminescence detection. 
  • Kinetic-dependent Killing of Oral Pathogens with Nitric Oxide. 
  • Kinetics and Mechanism of the Gold-Catalyzed Hydroamination of 1,1-Dimethylallene with N-Methylaniline. 
  • Kinetics and inhibition of reductive dechlorination of trichloroethene, cis-1,2-dichloroethene and vinyl chloride in a continuously fed anaerobic biofilm reactor. 
  • Kinetics and mechanism of exogenous anion exchange in FeFbpA-NTA: significance of periplasmic anion lability and anion binding activity of ferric binding protein A. 
  • Kinetics and mechanism of iron release from the bacterial ferric binding protein nFbp: exogenous anion influence and comparison with mammalian transferrin. 
  • Kinetics and mechanism of iron(III) complexation by ferric binding protein: the role of phosphate. 
  • Kinetics and mechanism of iron(III) dissociation from the dihydroxamate siderophores alcaligin and rhodotorulic acid. 
  • Kinetics and physiologic relevance of the inactivation of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, and antithrombin III by matrix metalloproteinases-1 (tissue collagenase), -2 (72-kDa gelatinase/type IV collagenase), and -3 (stromelysin). 
  • Kinetics of TCR use in response to repeated epitope-specific immunization. 
  • Kinetics of allosteric enzymes. 
  • Kinetics of bipedal locomotion during load carrying in capuchin monkeys. 
  • Kinetics of bisulfite-induced cytosine deamination in single-stranded DNA. 
  • Kinetics of cytokine expression during primary human immunodeficiency virus type 1 infection. 
  • Kinetics of cytokine expression in melanoma metastases classifies immune responsiveness. 
  • Kinetics of elimination of antithrombin III concentrate in heparinized patients. 
  • Kinetics of expansion of SIV Gag-specific CD8+ T lymphocytes following challenge of vaccinated macaques. 
  • Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes. 
  • Kinetics of human immunodeficiency virus type 1 (HIV-1) DNA and RNA synthesis during primary HIV-1 infection. 
  • Kinetics of immunoglobulin synthesis and secretion by resting and pokeweed mitogen-transformed human lymphocytes. 
  • Kinetics of interaction of disopyramide with the cardiac sodium channel: fast dissociation from open channels at normal rest potentials. 
  • Kinetics of interaction of the lidocaine metabolite glycylxylidide with the cardiac sodium channel. Additive blockade with lidocaine. 
  • Kinetics of iron release from ferric binding protein (FbpA): mechanistic implications in bacterial periplasm-to-cytosol Fe3+ transport. 
  • Kinetics of irreversible activation of adenylate cyclase of fat cell membranes by phosphonium and phosphoramidate analogs of gtp1. 
  • Kinetics of long-chain (sphingoid) base biosynthesis in intact LM cells: effects of varying the extracellular concentrations of serine and fatty acid precursors of this pathway. 
  • Kinetics of nonproteolytic incorporation of a protein ligand into thermally activated alpha 2-macroglobulin: evidence for a novel nascent state. 
  • Kinetics of pneumococcal antibodies among HIV-exposed, uninfected infants in Botswana. 
  • Kinetics of poliovirus uncoating in HeLa cells in a nonacidic environment. 
  • Kinetics of protein farnesyltransferase: sigmoidal vs hyperbolic behavior as a function of assay conditions. 
  • Kinetics of protein import into isolated Xenopus oocyte nuclei. 
  • Kinetics of protein-protein association explained by Brownian dynamics computer simulation. 
  • Kinetics of reduction of cytochrome c oxidase by dithionite and the effect of hydrogen peroxide. 
  • Kinetics of release of serotonin from isolated secretory granules. I. Amperometric detection of serotonin from electroporated granules. 
  • Kinetics of release of serotonin from isolated secretory granules. II. Ion exchange determines the diffusivity of serotonin. 
  • Kinetics of thermal unfolding of phenylalanine hydroxylase variants containing different metal cofactors (FeII, CoII, and ZnII) and their isokinetic relationship. 
  • L-[3H]Glutamate binding to hippocampal synaptic membranes: two binding sites discriminated by their differing affinities for quisqualate. 
  • L-selectin dimerization enhances tether formation to properly spaced ligand. 
  • Label free colorimetric biosensing using nanoparticles. 
  • Lack of enhancing effect of human anti-human immunodeficiency virus type 1 (HIV-1) antibody on HIV-1 infection of human blood monocytes and peritoneal macrophages. 
  • Laminin mediates tethering and spreading of colon cancer cells in physiological shear flow. 
  • Landing Kinematics and Kinetics at the Knee During Different Landing Tasks. 
  • Late Na channels in cardiac cells: the physiological role of background Na channels. 
  • Left-handed DNA helices, supercoiling, and the B-Z junction. 
  • Lefty inhibits receptor-regulated Smad phosphorylation induced by the activated transforming growth factor-beta receptor. 
  • Lefty proteins exhibit unique processing and activate the MAPK pathway. 
  • Length Specificity and Polymerization Mechanism of (1,3)-β-d-Glucan Synthase in Fungal Cell Wall Biosynthesis. 
  • Leucine metabolism during fasting and exercise. 
  • Leukocyte chemoattractant receptors. 
  • Leukocyte rolling on P-selectin: a three-dimensional numerical study of the effect of cytoplasmic viscosity. 
  • Leukocyte telomere dynamics and human hematopoietic stem cell kinetics during somatic growth. 
  • Levels of p53 protein increase with maturation in human hematopoietic cells. 
  • Ligand binding to transiently accessible sites: mechanisms for varying apparent binding rates. 
  • Ligation-state hydrogen exchange: coupled binding and folding equilibria in ribonuclease P protein. 
  • Light scattering by polymorphonuclear leukocytes stimulated to aggregate under various pharmacologic conditions. 
  • Limits of detection of regional differences in vasodilated flow in viable myocardium by first-pass magnetic resonance perfusion imaging. 
  • Linked folding and anion binding of the Bacillus subtilis ribonuclease P protein. 
  • Lipid monolayer states and their relationships to bilayers. 
  • Lipid solubility modulates pH potentiation of local anesthetic block of Vmax reactivation in guinea pig myocardium. 
  • Lipid specificity of beta-hydroxybutyrate dehydrogenase activation. 
  • Lipopolysaccharide and phorbol esters induce differentiation but have opposite effects on phosphatidylinositol turnover and Ca2+ mobilization in 70Z/3 pre-B lymphocytes. 
  • Lipoprotein (a) promotes plasmin inhibition by alpha 2-antiplasmin. 
  • Lipoprotein (a): purification and kinetic analysis. 
  • Lipoprotein a inhibits streptokinase-mediated activation of human plasminogen. 
  • Lipoprotein synthesis in the cockerel liver: effects of estrogen on hepatic polysomal messenger ribonucleic acid activities for the major apoproteins in very loow and high density lipoproteins and for albumin and evidence for precursors to these secretory proteins. 
  • Liposome-mediated augmentation of superoxide dismutase in endothelial cells prevents oxygen injury. 
  • Loading effect of fibroblast-myocyte coupling on resting potential, impulse propagation, and repolarization: insights from a microstructure model. 
  • Local encoding of computationally designed enzyme activity. 
  • Localization of a cryptic binding site for tenascin on fibronectin. 
  • Long-chain (sphingoid) bases inhibit multistage carcinogenesis in mouse C3H/10T1/2 cells treated with radiation and phorbol 12-myristate 13-acetate. 
  • Long-range electron transfer in myoglobin. 
  • Longitudinal study of urinary excretion of phosphate, calcium, and uric acid in mutant NHERF-1 null mice. 
  • Longitudinal variation in muscle protein expression and contraction kinetics of largemouth bass axial muscle. 
  • Loss of beta-adrenergic receptor-guanine nucleotide regulatory protein interactions accompanies decline in catecholamine responsiveness of adenylate cyclase in maturing rat erythrocytes. 
  • Low-Avidity Autoantibodies against Bactericidal/Permeability-Increasing Protein Occur in Gram-Negative and Gram-Positive Bacteremia. 
  • Lysine(164)alpha of protein farnesyltransferase is important for both CaaX substrate binding and catalysis. 
  • Lysine-Specific Demethylase 1A (KDM1A/LSD1): Product Recognition and Kinetic Analysis of Full-Length Histones. 
  • Macromolecular beta-adrenergic antagonists discriminating between receptor and antibody. 
  • Macrophage activation downregulates the degradative capacity of the phagosome. 
  • Magnesium dependence of agonist binding to adenylate cyclase-coupled hormone receptors. 
  • Magnetization of the sulfite and nitrite complexes of oxidized sulfite and nitrite reductases: EPR silent spin S = 1/2 states. 
  • Mammalian alpha 1-adrenergic receptor. Purification and characterization of the native receptor ligand binding subunit. 
  • Mammalian chymotrypsin-like enzymes. Comparative reactivities of rat mast cell proteases, human and dog skin chymases, and human cathepsin G with peptide 4-nitroanilide substrates and with peptide chloromethyl ketone and sulfonyl fluoride inhibitors. 
  • Mammalian protein geranylgeranyltransferase. Subunit composition and metal requirements. 
  • Manipulation of ligand binding affinity by exploitation of conformational coupling. 
  • Mapping of calmodulin-binding domain of Ca2+/calmodulin-dependent protein kinase II from rat brain. 
  • Mapping the binding sites of human erythrocyte ankyrin for the anion exchanger and spectrin. 
  • Marked QRS complex abnormalities and sodium channel blockade by propoxyphene reversed with lidocaine. 
  • Markov state models based on milestoning 
  • Massive computational acceleration by using neural networks to emulate mechanism-based biological models. 
  • Mathematical analysis of the regulation of competing methyltransferases. 
  • Mathematical model insights into arsenic detoxification. 
  • Mathematical models of folate-mediated one-carbon metabolism. 
  • Maturation of acetylcholinesterase expression in tracheal smooth muscle contraction. 
  • Maturation of the adrenal medulla. III. Practical and theoretical considerations of age-dependent alterations in kinetics of incorporation of catecholamines and non-catecholamines. 
  • Maturational differences in chlorpyrifos-oxonase activity may contribute to age-related sensitivity to chlorpyrifos. 
  • Meal-anticipatory glucagon-like peptide-1 secretion in rats. 
  • Measurement of interbilayer adhesion energies. 
  • Measurements from normal umbilical cord blood of four lysosomal enzymatic activities: alpha-L-iduronidase (Hurler), galactocerebrosidase (globoid cell leukodystrophy), arylsulfatase A (metachromatic leukodystrophy), arylsulfatase B (Maroteaux-Lamy). 
  • Mechanism for catalysis and regulation of adenosine 5'-triphosphate hydrolysis by chloroplast coupling factor 1. 
  • Mechanism of Epstein-Barr virus-induced human B-lymphocyte activation. 
  • Mechanism of OMP decarboxylation in orotidine 5'-monophosphate decarboxylase. 
  • Mechanism of action of Vibrio cholerae enterotoxin. Effects on adenylate cyclase of toad and rat erythrocyte plasma membranes. 
  • Mechanism of action of a respiratory inhibitor from the gill tissue of the sporulating common mushroom, Agaricus bisporus. 
  • Mechanism of action of inter-alpha-trypsin inhibitor. 
  • Mechanism of activation of adenylate cyclase by Vibrio cholerae enterotoxin. 
  • Mechanism of activation of adenylate cyclase by Vibrio cholerae enterotoxin. Relations to the mode of activation by hormones. 
  • Mechanism of activation of human plasminogen by the activator complex, streptokinase-plasmin. 
  • Mechanism of assembly of the Bis(Molybdopterin guanine dinucleotide)molybdenum cofactor in Rhodobacter sphaeroides dimethyl sulfoxide reductase. 
  • Mechanism of bradykinin-stimulated prostacyclin synthesis in porcine aortic endothelial cells. 
  • Mechanism of deoxyadenosine-induced catabolism of adenine ribonucleotides in adenosine deaminase-inhibited human T lymphoblastoid cells. 
  • Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes. 
  • Mechanism of insulin incorporation into alpha 2-macroglobulin: implications for the study of peptide and growth factor binding. 
  • Mechanism of nicotinamide-adenine dinucleotide binding to rabbit muscle glyceraldehyde 3-phosphate dehydrogenase. 
  • Mechanism of palladium-catalyzed diene cyclization/hydrosilylation: direct observation of intramolecular carbometalation. 
  • Mechanism of specific site location and DNA cleavage by EcoR I endonuclease. 
  • Mechanism of time-dependent inhibition of 5 alpha-reductases by delta 1-4-azasteroids: toward perfection of rates of time-dependent inhibition by using ligand-binding energies. 
  • Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight. 
  • Mechanisms for regulation of calmodulin kinase IIalpha by Ca(2+)/calmodulin and autophosphorylation of threonine 286. 
  • Mechanisms of autoantibody production in autoimmune MRL mice. 
  • Mechanisms of corticosteroid action on lymphocyte subpopulations. V. Effects of in vivo hydrocortisone on the circulatory kinetics and function of naturally occuring and mitogen-induced suppressor cells in man. 
  • Mechanisms of inactivation of molybdoenzymes by cyanide. 
  • Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics. 
  • Mechanistic aspects of carbon monoxide formation from volatile anesthetics. 
  • Mechanistic characterization of the tetraacyldisaccharide-1-phosphate 4'-kinase LpxK involved in lipid A biosynthesis. 
  • Mediator-free amperometric determination of toxic substances based on their inhibition of immobilized horseradish peroxidase. 
  • Melittin-induced bilayer leakage depends on lipid material properties: evidence for toroidal pores. 
  • Melphalan transport, glutathione levels, and glutathione-S-transferase activity in human medulloblastoma. 
  • Membrane abnormalities of Huntington's chorea fibroblasts in culture. 
  • Membrane binding of plasmid DNA and endocytic pathways are involved in electrotransfection of mammalian cells. 
  • Membrane currents underlying bursting pacemaker activity and spike frequency adaptation in invertebrates. 
  • Membrane protein mediation of thromboxane A2-induced platelet aggregation. 
  • Meta-[131I]iodobenzylguanidine uptake and meta-[211At]astatobenzylguanidine treatment in human medulloblastoma cell lines. 
  • Metabolic changes following eccentric exercise in trained and untrained men. 
  • Metabolic cooperation between vascular endothelial cells and smooth muscle cells in co-culture: changes in low density lipoprotein metabolism. 
  • Metabolic division of labor in microbial systems. 
  • Metabolic fate of L-arginine in relation to microbiostatic capability of murine macrophages. 
  • Metabolic impact of adenovirus-mediated overexpression of the glucose-6-phosphatase catalytic subunit in hepatocytes. 
  • Metabolism and transport of galactose by rat intestine. 
  • Metabolism of 22-oxacalcitriol by a vitamin D-inducible pathway in cultured parathyroid cells. 
  • Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes. 
  • Metabolism of levo-alpha-Acetylmethadol (LAAM) by human liver cytochrome P450: involvement of CYP3A4 characterized by atypical kinetics with two binding sites. 
  • Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation. 
  • Metabolism of threo-beta-fluoroaspartate by H4 cells. Inhibition of adenylosuccinate lyase by fluoro analogs of its substrates. 
  • Metal ion interactions with Limulus polyphemus and Callinectes sapidus hemocyanins: stoichiometry and structural and functional consequences of calcium(II), cadmium(II), zinc(II), and mercury(II) binding. 
  • Metalloporphyrins are potent inhibitors of lipid peroxidation. 
  • Methionine oxidation of monomeric lambda repressor: the denatured state ensemble under nondenaturing conditions. 
  • Methionine to glutamine substitutions in the C-terminal domain of calmodulin impair the activation of three protein kinases. 
  • Method for studying kinetics of light-induced transport across membranes. 
  • Microassay for the photometric quantitation of cell-associated plasminogen activator using a chromogenic tripeptide substrate. 
  • Microbe-Encapsulated Silica Gel Biosorbents for Selective Extraction of Scandium from Coal Byproducts. 
  • Microsecond protein folding through a compact transition state. 
  • Microsomal membranes contain a high affinity binding site for prenylated peptides. 
  • Microtubule dynamic instability and GTP hydrolysis. 
  • Microtubule treadmilling in vitro investigated by fluorescence speckle and confocal microscopy. 
  • Microtubules accelerate the kinase activity of Aurora-B by a reduction in dimensionality. 
  • Microwave-field-driven acoustic modes in DNA. 
  • Minimally invasive total knee arthroplasty using the contralateral knee as a control group: a case-control study. 
  • Misincorporation and mispaired primer extension by human immunodeficiency virus reverse transcriptase. 
  • Mismatch-, MutS-, MutL-, and helicase II-dependent unwinding from the single-strand break of an incised heteroduplex. 
  • Mitochondrial benzodiazepine receptors regulate steroid biosynthesis. 
  • Mitochondrial generation of reactive oxygen species after brain ischemia in the rat. 
  • Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues. 
  • Mitochondrial respiration after sepsis and prolonged hypoxia. 
  • Mitoxantrone and ametantrone inhibit hydroperoxide-dependent initiation and propagation reactions in fatty acid peroxidation. 
  • Model accounting for the effects of pulling-device stiffness in the analyses of single-molecule force measurements 
  • Model of alpha 2-macroglobulin structure and function. 
  • Modeling bacteriophage-induced inactivation of Escherichia coli utilizing particle aggregation kinetics. 
  • Modeling biological systems using Dynetica--a simulator of dynamic networks. 
  • Modeling the Mechanisms by Which Coexisting Biomolecular RNA-Protein Condensates Form. 
  • Modeling the relative impact of capsular tissue effects on implanted glucose sensor time lag and signal attenuation. 
  • Models of dopaminergic and serotonergic signaling. 
  • Modifications of boronic ester pro-chelators triggered by hydrogen peroxide tune reactivity to inhibit metal-promoted oxidative stress. 
  • Modulating unimolecular charge transfer by exciting bridge vibrations. 
  • Modulation of Hoogsteen dynamics on DNA recognition. 
  • Modulation of MutS ATP hydrolysis by DNA cofactors. 
  • Modulation of cisplatin resistance by 2'-deoxy-5-azacytidine in human ovarian tumor cell lines. 
  • Modulation of cytokine-induced cardiac myocyte apoptosis by nitric oxide, Bak, and Bcl-x. 
  • Modulation of cytotoxicity of menadione sodium bisulfite versus leukemia L1210 by the acid-soluble thiol pool. 
  • Modulation of glutathione peroxidase expression by selenium: effect on human MCF-7 breast cancer cell transfectants expressing a cellular glutathione peroxidase cDNA and doxorubicin-resistant MCF-7 cells. 
  • Modulation of inositol phospholipid metabolism by polyamines. 
  • Modulation of ligand binding affinity of the adipocyte lipid-binding protein by selective mutation. Analysis in vitro and in situ. 
  • Modulation of plasminogen activation and type IV collagenase activity by a synthetic peptide derived from the laminin A chain. 
  • Modulation of potassium transport in cultured retinal pigment epithelium and retinal glial cells by serum and epidermal growth factor. 
  • Modulation of spectrin-actin assembly by erythrocyte adducin. 
  • Modulation of the free sphingosine levels in human neutrophils by phorbol esters and other factors. 
  • Modulation of tissue plasminogen activator-catalyzed plasminogen activation by synthetic peptides derived from the amino-terminal heparin binding domain of fibronectin. 
  • Molecular basis of differential sensitivity of insect sodium channels to DCJW, a bioactive metabolite of the oxadiazine insecticide indoxacarb. 
  • Molecular basis of sulfite oxidase deficiency from the structure of sulfite oxidase. 
  • Molecular basis of the biological function of molybdenum. Effect of tungsten on xanthine oxidase and sulfite oxidase in the rat. 
  • Molecular biology of adrenergic receptors. 
  • Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A. 
  • Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins. 
  • Molecular definition of a novel inositol polyphosphate metabolic pathway initiated by inositol 1,4,5-trisphosphate 3-kinase activity in Saccharomyces cerevisiae. 
  • Molecular mechanisms of coupling in hormone receptor-adenylate cyclase systems. 
  • Molecular mechanisms of pathogenesis. 
  • Molecular pharmacology of adenylate cyclase-coupled alpha- and beta-adrenergic receptors. 
  • Molecular pharmacology of alpha adrenergic receptors: utilization of [3H]dihydroergocryptine binding in the study of pharmacological receptor alterations. 
  • Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry. 
  • Monoamine oxidase and catechol-O-methyltransferase activity in hamster and rat insulinomas. 
  • Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas. 
  • Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases. 
  • Monoclonal antibody OKT3-induced T cell proliferation: differential role of HLA class II determinants expressed by T cells and monocytes. 
  • Monocytoid differentiation of freshly isolated human myeloid leukemia cells and HL-60 cells induced by the glutamine antagonist acivicin. 
  • Mu opioid receptor-mediated modulation of synaptic currents in dentate granule cells of rat hippocampus. 
  • Mu- and kappa-opiate receptor control of prolactin secretion in rats: ontogeny and interaction with serotonin. 
  • Multilayer adsorption of lysozyme on a hydrophobic substrate. 
  • Multinodular focal fatty infiltration of the liver: atypical imaging findings on delayed T1-weighted Gd-BOPTA-enhanced liver-specific MR images. 
  • Multiple Surface Regions on the Niemann-Pick C2 Protein Facilitate Intracellular Cholesterol Transport. 
  • Multiple autocrine growth factors modulate vascular smooth muscle cell growth response to angiotensin II. 
  • Multiple calcium-mediated effector mechanisms regulate chloride secretory responses in T84-cells. 
  • Multiple effects of N, N' dicyclohexyl carbodiimide on the beta-adrenergic receptor--adenylate cyclase system in frog erythrocytes. 
  • Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors. 
  • Multivariate proteomic analysis of murine embryonic stem cell self-renewal versus differentiation signaling. 
  • MutS and MutL activate DNA helicase II in a mismatch-dependent manner. 
  • MutS mediates heteroduplex loop formation by a translocation mechanism. 
  • Mutagenesis of the phosphate-binding pocket of KDPG aldolase enhances selectivity for hydrophobic substrates. 
  • Mutagenesis studies of substrate recognition and catalysis in the sortase A transpeptidase from Staphylococcus aureus. 
  • Mutation detection with MutH, MutL, and MutS mismatch repair proteins. 
  • Mutational Dissection of Telomeric DNA Binding Requirements of G4 Resolvase 1 Shows that G4-Structure and Certain 3'-Tail Sequences Are Sufficient for Tight and Complete Binding. 
  • Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2. 
  • Mutational analysis of active site residues in the Staphylococcus aureus transpeptidase SrtA. 
  • Mutational analysis of potential zinc-binding residues in the active site of the enterococcal D-Ala-D-Ala dipeptidase VanX. 
  • Mutational analysis of the autoinhibitory domain of calmodulin kinase II. 
  • Mutational analysis of the fractalkine chemokine domain. Basic amino acid residues differentially contribute to CX3CR1 binding, signaling, and cell adhesion. 
  • Mutations in Saccharomyces cerevisiae which confer resistance to several amino acid analogs. 
  • Mutations in the active site of Escherichia coli phosphofructokinase. 
  • Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a novel IL-12Rbeta1 isoform that enhances DC migration. 
  • Myelin basic protein stimulates plasminogen activation via tissue plasminogen activator following binding to independent l-lysine-containing domains. 
  • Myocardial guanylate cyclase: properties of the enzyme and effects of cholinergic agonists in vitro. 
  • Myocardial magnetic resonance imaging contrast agent concentrations after reversible and irreversible ischemic injury. 
  • N-Formylmethionyl peptide receptors on equine leukocytes initiate secretion but not chemotaxis. 
  • N-formyl peptide receptors internalize but do not recycle in the absence of arrestins. 
  • N-methyl-D-aspartate receptor regulation of uncompetitive antagonist binding in rat brain membranes: kinetic analysis. 
  • N2 fixation estimates in real-time by cavity ring-down laser absorption spectroscopy 
  • N7-cyanoborane-2'-deoxyguanosine 5'-triphosphate is a good substrate for DNA polymerase. 
  • NADPH-dependent oxygen reductase activity in pulmonary macrophages. 
  • Na channel kinetics remain stable during perforated-patch recordings. 
  • Naltrexone disposition in man after subcutaneous administration. 
  • Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes. 
  • Ncd motor binding and transport in the spindle. 
  • Near infrared monitoring of human skeletal muscle oxygenation during forearm ischemia. 
  • Near-infrared monitoring of cerebral oxygen sufficiency. I. Spectra of cytochrome c oxidase. 
  • Nearest neighbor analysis for brain synapsin I. Evidence from in vitro reassociation assays for association with membrane protein(s) and the Mr = 68,000 neurofilament subunit. 
  • Neck-motor interactions trigger rotation of the kinesin stalk. 
  • Negative cooperativity among beta-adrenergic receptors in frog erythrocyte membranes. 
  • Neonatal plasminogen displays altered cell surface binding and activation kinetics. Correlation with increased glycosylation of the protein. 
  • Neonatal rat pinealocytes: typical and atypical characteristics of [125I]iodohydroxybenzylpindolol binding and adenosine 3',5'-monophosphate accumulation. 
  • Neural input and the development of adrenergic intracellular signaling: neonatal denervation evokes neither receptor upregulation nor persistent supersensitivity of adenylate cyclase. 
  • Neurokinin receptors mediating substance P-induced contraction in adult rabbit airways. 
  • Neuronal nitric-oxide synthase interaction with calmodulin-troponin C chimeras. 
  • Neurotensin interacts with dopaminergic neurons in rat brain. 
  • Neurotensin releases norepinephrine differentially from perfused hypothalamus of sated and fasted rat. 
  • Neurotrophin regulation of ionic currents and cell size depends on cell context. 
  • Neutral evolution of the nonbinding region of the anthocyanin regulatory gene Ipmyb1 in Ipomoea. 
  • Neutral proteinase of rabbit skin: an enzyme capable of degrading skin protein and inducing an inflammatory response. 
  • Neutralization of sensitized virus by purified components of complement. 
  • Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells. 
  • New class of potent catalysts of O2.-dismutation. Mn(III) ortho-methoxyethylpyridyl- and di-ortho-methoxyethylimidazolylporphyrins. 
  • New sensitive micro-measurements of dynamic surface tension and diffusion coefficients: Validated and tested for the adsorption of 1-Octanol at a microscopic air-water interface and its dissolution into water. 
  • Newly identified brain potassium channels gated by the guanine nucleotide binding protein Go. 
  • Nicotinic cholinergic receptors labeled by [3H]acetylcholine in rat brain. 
  • Nitric oxide binding to human ferrihemoglobins cross-linked between either alpha or beta subunits. 
  • Nitric oxide synthase from cerebellum catalyzes the formation of equimolar quantities of nitric oxide and citrulline from L-arginine. 
  • Nitric oxide-generating polymers reduce platelet adhesion and smooth muscle cell proliferation. 
  • Nitric oxide-releasing polyurethane-PEG copolymer containing the YIGSR peptide promotes endothelialization with decreased platelet adhesion. 
  • Noise reduction by diffusional dissipation in a minimal quorum sensing motif. 
  • Noise-induced current switching in semiconductor superlattices: observation of nonexponential kinetics in a high-dimensional system. 
  • Noncatalytic cGMP-binding sites of amphibian rod cGMP phosphodiesterase control interaction with its inhibitory gamma-subunits. A putative regulatory mechanism of the rod photoresponse. 
  • Noncatalytic domains of RGS9-1.Gbeta 5L play a decisive role in establishing its substrate specificity. 
  • Noncompartmental kinetic analysis of DCE-MRI data from malignant tumors: Application to glioblastoma treated with bevacizumab. 
  • Nonequivalence of the flavin adenine dinucleotide moieties of chicken liver xanthine dehydrogenase. 
  • Nonneutralizing HIV-1 gp41 envelope cluster II human monoclonal antibodies show polyreactivity for binding to phospholipids and protein autoantigens. 
  • Nontoxic irreversible inhibitors of factors IXa, Xa, and thrombin: potential therapeutic agents for the in vivo regulation of thrombin generation and activity. 
  • Norethynodrel metabolites in human plasma and urine. 
  • Novel aspects of the biochemistry of the molybdenum cofactor. 
  • Nuclear magnetic resonance study of ligand binding to Mn-aspartate transcarbamylase. 
  • Nuclear phosphatidylinositols decrease during S-phase of the cell cycle in HeLa cells. 
  • Nuclear transport kinetics in microarrays of nuclear envelope patches. 
  • Nucleation of microtubule assembly. Experimental kinetics, computer fitting of models, and observations on tubulin rings. 
  • Nucleosome Turnover Regulates Histone Methylation Patterns over the Genome. 
  • Nucleotide interactions with the dicyclohexylcarbodiimide-sensitive adenosinetriphosphatase from spinach chloroplasts. 
  • Nucleotide-promoted release of hMutSalpha from heteroduplex DNA is consistent with an ATP-dependent translocation mechanism. 
  • Nutritional regulation of the placental lactogen receptor in fetal liver: implications for fetal metabolism and growth. 
  • Ocular albumin fluorophotometric quantitation of endotoxin-induced vascular permeability. 
  • Ocular penetration of 5-fluorocytosine. 
  • Okadaic acid induces both augmentation and inhibition of beta 2-adrenergic stimulation of cAMP accumulation in S49 lymphoma cells. 
  • Okadaic acid mimics the action of insulin in stimulating protein kinase activity in isolated adipocytes. The role of protein phosphatase 2a in attenuation of the signal. 
  • Oligonucleotide enhanced cytotoxicity of Idarubicin for lymphoma cells. 
  • On stability designs in drug shelf-life estimation. 
  • On the assessment of similarity for dissolution profiles of two drug products. 
  • On the reaction of ferric heme proteins with nitrite and sulfite. 
  • On the role of deoxyribonucleic acid polymerase in determining mutation rates. Characterization of the defect in the T4 deoxyribonucleic acid polymerase caused by the ts L88 mutation. 
  • One-carbon metabolism and epigenetics: understanding the specificity. 
  • Onset of feedback reactions underlying vertebrate rod photoreceptor light adaptation. 
  • Ontogenic expression of acetylcholinesterase activity in trachealis of young swine. 
  • Ontogeny of (--)-[3H]norepinephrine uptake properties of synaptic storage vesicles of rat brain. 
  • Ontogeny of endocrine responses to methadone in rats. 
  • Ontogeny of mu- and kappa-opiate receptor control of the hypothalamo-pituitary-adrenal axis in rats. 
  • Open Na+ channel blockade: multiple rest states revealed by channel interactions with disopyramide and quinidine. 
  • Opioid inhibition of luteinizing hormone release declines with age and acyclicity in female rats. 
  • Optical imaging reveals elevated intracellular chloride in hippocampal pyramidal neurons after oxidative stress. 
  • Optical rotation of noncovalent aggregates. 
  • Optimization of the lariat ether carboxylic acid host structure for ferrioxamine B: demonstration of a second coordination shell chelate effect. 
  • Optimization of vaccine responses with an E1, E2b and E3-deleted Ad5 vector circumvents pre-existing anti-vector immunity. 
  • Optimizing the substrate specificity of a group I intron ribozyme. 
  • Optokinetic response in monkey: underlying mechanisms and their sensitivity to long-term adaptive changes in vestibuloocular reflex. 
  • Orbital-dependent correlation energy in density-functional theory based on a second-order perturbation approach: success and failure. 
  • Orchidectomy induces temporal and regional changes in the synthesis and processing of the LHRH prohormone in the rat brain. 
  • Ordered phosphorylation of p42mapk by MAP kinase kinase. 
  • Orthogonal site-specific protein modification by engineering reversible thiol protection mechanisms. 
  • Osmolyte-induced folding of an intrinsically disordered protein: folding mechanism in the absence of ligand. 
  • Outcomes of patients with acute coronary syndromes and prior coronary artery bypass grafting: results from the platelet glycoprotein IIb/IIIa in unstable angina: receptor suppression using integrilin therapy (PURSUIT) trial. 
  • Ovalbumin gene: purification of the coding strand. 
  • Over 20% (15)N Hyperpolarization in Under One Minute for Metronidazole, an Antibiotic and Hypoxia Probe. 
  • Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors. 
  • Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion. 
  • Overproduction and purification of glutaryl 7-amino cephalosporanic acid acylase. 
  • Ovine placental lactogen stimulates glycogen synthesis in fetal rat hepatocytes. 
  • Oxalate decarboxylase uses electron hole hopping for catalysis. 
  • Oxidative stress and adenine nucleotide control of mitochondrial permeability transition. 
  • Oxidized dimeric Scapharca inaequivalvis. Co-driven perturbation of the redox equilibrium. 
  • Oxygen and Perfusion Kinetics in Response to Fractionated Radiation Therapy in FaDu Head and Neck Cancer Xenografts Are Related to Treatment Outcome. 
  • Oxygen binding by Limulus polyphemus hemocyanin: allosteric modulation by chloride ions. 
  • Oxygen binding domains of Helisoma trivolvis hemoglobin. 
  • Oxygen kinetics in the vitreous substitute perfluorotributylamine: a 19F NMR study in vivo. 
  • Oxygen transport in resting and contracting hamster cremaster muscles: experimental and theoretical microvascular studies. 
  • PDGF-stimulated fibroblast proliferation is enhanced synergistically by receptor-recognized alpha 2-macroglobulin. 
  • PH-Dependent effects of quinidine on the kinetics of dV/dtmax in guinea pig ventricular myocardium. 
  • PLGA and PHBV Microsphere Formulations and Solid-State Characterization: Possible Implications for Local Delivery of Fusidic Acid for the Treatment and Prevention of Orthopaedic Infections 
  • Palmitoylation of neurofascin at a site in the membrane-spanning domain highly conserved among the L1 family of cell adhesion molecules. 
  • Pancreatic hormone response to neuropeptide Y (NPY) perifusion in vitro. 
  • Paradoxical effects of methylmercury on the kinetics of cytochrome c oxidase. 
  • Parallel modulation of catecholamine activation of adenylate cyclase and formation of the high-affinity agonist.receptor complex in turkey erythrocyte membranes by temperature and cis-vaccenic acid. 
  • Parathyroid hormone effects on serum 1,25-dihydroxyvitamin D levels in patients with X-linked hypophosphatemic rickets: evidence for abnormal 25-hydroxyvitamin D-1-hydroxylase activity. 
  • Partial demixing of RNA-protein complexes leads to intradroplet patterning in phase-separated biological condensates. 
  • Partial restoration of normal functional properties in carboxypeptidase A-digested hemoglobin. 
  • Passive infusion of immune serum into simian immunodeficiency virus-infected rhesus macaques undergoing a rapid disease course has minimal effect on plasma viremia. 
  • Pathogenesis of A⁻β⁺ ketosis-prone diabetes. 
  • Pathways of folding of reduced bovine pancreatic ribonuclease. 
  • Pde1 phosphodiesterase modulates cyclic AMP levels through a protein kinase A-mediated negative feedback loop in Cryptococcus neoformans. 
  • Peak knee biomechanics and limb symmetry following unilateral anterior cruciate ligament reconstruction: Associations of walking gait and jump-landing outcomes. 
  • Penetration of new azole compounds into the eye and efficacy in experimental Candida endophthalmitis. 
  • Peptide YY inhibits meal-stimulated pancreatic and gastric secretion. 
  • Peptide specificity determinants at P-7 and P-6 enhance the catalytic efficiency of Ca2+/calmodulin-dependent protein kinase I in the absence of activation loop phosphorylation. 
  • Perfusion of single tumor microvessels: application to vascular permeability measurement. 
  • Peripheral nerve grafts: the relationship of axonal growth cone and biomechanical properties. 
  • Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells. 
  • Persistence of herpes simplex virus type-2 genome in a human leukemic cell line. 
  • Pharmacokinetic analysis of the perivascular distribution of bifunctional antibodies and haptens: comparison with experimental data. 
  • Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies. 
  • Pharmacokinetic modeling of the lung burden from repeated inhalation of nickel aerosols. 
  • Pharmacokinetic profile of caffeine in the premature newborn infant with apnea. 
  • Pharmacokinetic studies: their role in determining therapeutic efficacy of agents designed to prevent sudden death. 
  • Pharmacokinetic-hemodynamic studies of disopyramide. 
  • Pharmacokinetic-hemodynamic studies of intravenous nitroglycerin in congestive cardiac failure. 
  • Pharmacokinetic-hemodynamic studies of nitroglycerin in congestive cardiac failure. 
  • Pharmacokinetic-hemodynamic studies of nitroglycerin ointment in congestive heart failure. 
  • Pharmacokinetics of N-formimidoyl thienamycin and influence of a renal dipeptidase inhibitor in experimental meningitis. 
  • Pharmacokinetics of cefoperazone, moxalactam, cefotaxime, trimethoprim and sulphamethoxazole in experimental meningitis. 
  • Pharmacokinetics of diaziquone after three different dosage regimens. 
  • Pharmacokinetics of pentobarbital enantiomers as determined by enantioselective radioimmunoassay after administration of racemate to humans and rabbits. 
  • Pharmacokinetics of radiolabeled monoclonal antibody B6.2 in patients with metastatic breast cancer. 
  • Phase I and clinical pharmacology study of trimetrexate administered weekly for three weeks. 
  • Phase I study of pharmacological and immunological effects of human lymphoblastoid interferon given to patients with cancer. 
  • Phase-lifetime spectrophotometry of deoxycholate-purified bacteriorhodopsin reconstituted into asolectin vesicles. 
  • Phase-lifetime spectrophotometry of membranes from ion flux mutants of Halobacterium halobium. 
  • Phasic ion channel blockade. A kinetic model and parameter estimation procedure. 
  • Phenamil: an irreversible inhibitor of sodium channels in the toad urinary bladder. 
  • Phencyclidine and phenylcyclohexene disposition after smoking phencyclidine. 
  • Phencyclidine disposition after intravenous and oral doses. 
  • Phencyclidine disposition in humans after small doses of radiolabeled drug. 
  • Phenylalanine hydroxylase activity in mammalian cells. 
  • Phenylalanine hydroxylase in dilute lethal mice. 
  • Phorbol diester-induced H2O2 production by peritoneal macrophages. Different H2O2 production by macrophages from normal and BCG-infected mice despite comparable phorbol diester receptors. 
  • Phorbol myristate acetate mediates redistribution of protein kinase C in human neutrophils: potential role in the activation of the respiratory burst enzyme. 
  • Phosphatidic acid modulates Cl- secretion in T84 cells: varying effects depending on mode of stimulation. 
  • Phosphatidylcholine transfer protein promotes apolipoprotein A-I-mediated lipid efflux in Chinese hamster ovary cells. 
  • Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10). 
  • Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase. 
  • Phosphorylation of Gz alpha by protein kinase C blocks interaction with the beta gamma complex. 
  • Phosphorylation of Gz in human platelets. Selectivity and site of modification. 
  • Phosphorylation of the B1 (CD20) molecule by normal and malignant human B lymphocytes. 
  • Phosphorylation of the cardiac muscarinic receptor in intact chick heart and its regulation by a muscarinic agonist. 
  • Phosphorylation sites on two domains of the beta 2-adrenergic receptor are involved in distinct pathways of receptor desensitization. 
  • Phosphotyrosine and phosphoprotein phosphatase activity of alkaline phosphatase in mineralizing cartilage. 
  • Photoaffinity cross-linking of a radioiodinated probe, 125I-A55453, into alpha 1-adrenergic receptors. 
  • Photoaffinity labeling of mammalian alpha 1-adrenergic receptors. Identification of the ligand binding subunit with a high affinity radioiodinated probe. 
  • Photoaffinity labeling of the beta-adrenergic receptor. 
  • Photodegradation pathways of nonabrominated diphenyl ethers, 2-ethylhexyltetrabromobenzoate and di(2-ethylhexyl)tetrabromophthalate: identifying potential markers of photodegradation. 
  • Phylogenetic comparisons implicate sex hormone-binding globulin in "masculinization" of the female spotted hyena (Crocuta crocuta). 
  • Physical and chemical properties of rabbit muscle phosphofructokinase cross-linked with dimethyl suberimidate. 
  • Physical constraints on charge transport through bacterial nanowires. 
  • Physical organic chemistry of supramolecular polymers. 
  • Physical properties of human alpha 2-macroglobulin following reaction with methylamine and trypsin. 
  • Physicochemical properties of rat testis Ca2+-dependent regulator protein of cyclic nucleotide phosphodiesterase. Relationship of Ca2+-binding, conformational changes, and phosphodiesterase activity. 
  • Physiological mechanisms mediating enhanced force generation during development and immune sensitization. 
  • Pigment formation from L-tryptophan by a particulate fraction from an Achromobacter species. 
  • Placental lactogen receptors in maternal sheep liver: effects of fasting and refeeding. 
  • Plasma clearance and liver uptake of chylomicron remnants generated by hepatic lipase lipolysis: evidence for a lactoferrin-sensitive and apolipoprotein E-independent pathway. 
  • Plasma secretin, CCK, and pancreatic secretion in response to dietary fat in the rat. 
  • Plasmin binding to the plasminogen receptor enhances catalytic efficiency and activates the receptor for subsequent ligand binding. 
  • Plasticity of lipid-protein interactions in the function and topogenesis of the membrane protein lactose permease from Escherichia coli. 
  • Platelet alpha 2-adrenergic receptors in schizophrenic patients before and after phenothiazine treatment. 
  • Platelet alpha-2-adrenergic dysfunction in negative symptom schizophrenia: a preliminary study. 
  • Platelet alpha2-adrenergic receptor coupling efficiency to Gi protein in subjects with post-traumatic stress disorder and normal controls. 
  • Platelet mitochondrial complex I and I+III activities do not correlate with cerebral mitochondrial oxidative metabolism. 
  • Platelet procoagulant complex assembly in a tissue factor-initiated system. 
  • Platelet receptors for human Factor VIII/von Willebrand protein: functional correlation of receptor occupancy and ristocetin-induced platelet aggregation. 
  • Platelet-derived growth factor enhances granulosa cell luteinizing hormone receptor induction by follicle-stimulating hormone and serum. 
  • Platelet-derived growth factor receptors form a high affinity state in membrane preparations. Kinetics and affinity cross-linking studies. 
  • Point mutations alter the mechanical stability of immunoglobulin modules. 
  • Polarized expression of cAMP-activated chloride channels in isolated epithelial cells. 
  • Polarized monocyte response to cytokine stimulation. 
  • Poliovirus replicase stimulation by terminal uridylyl transferase. 
  • Polyamine stimulation of protein phosphatase-2A from rat liver using a non-protein phosphoester substrate. 
  • Polyethylene glycol modification of serpins improves therapeutic potential. 
  • Polyethylene glycol-stimulated microsomal GTP hydrolysis. Relationship to GTP-mediated Ca2+ release. 
  • Population dynamics of ingested Clostridium difficile in the gastrointestinal tract of the Syrian hamster. 
  • Post-transcriptional inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase by Gö6976 in murine microglia. 
  • Potent beta-adrenergic antagonist possessing chemically reactive group. 
  • Potent inhibition of human immunodeficiency virus type 1 (HIV-1) replication by inducible expression of HIV-1 PR multimers. 
  • Potential antiglioma activity of 9-hydroxy-2-N-methylellipticine as determined by pharmacological and human tumor clonogenic cell studies. 
  • Potential role of WAF1/Cip1/p21 as a mediator of TGF-beta cytoinhibitory effect. 
  • Potential value of cefoperazone in bacterial meningitis: experimental studies. 
  • Predicting outcome of procedures to slow intestinal transit. 
  • Predictors of Superior Recovery Kinetics in Adult Cervical Deformity Correction: An Analysis Using a Novel Area Under the Curve Methodology. 
  • Predominant envelope variable loop 2-specific and gp120-specific antibody-dependent cellular cytotoxicity antibody responses in acutely SIV-infected African green monkeys. 
  • Preferential inhibition of Akt and killing of Akt-dependent cancer cells by rationally designed phosphatidylinositol ether lipid analogues. 
  • Preferential synthesis of yeast mitochondrial DNA in alpha factor-arrested cells. 
  • Preliminary validation of varicella zoster virus thymidine kinase as a novel reporter gene for PET. 
  • Prenylated peptides in identification of specific binding proteins. 
  • Preorganized secondary structure as an important determinant of fast protein folding. 
  • Preparation and biological evaluation of an astatine-211 labeled biotin conjugate: biotinyl-3-[211 At]astatoanilide. 
  • Preparation of Rh[16aneS4-diol](211)At and Ir[16aneS4-diol](211)At complexes as potential precursors for astatine radiopharmaceuticals. Part I: Synthesis. 
  • Pressure-mediated oligonucleotide transfection of rat and human cardiovascular tissues. 
  • Presynaptic nicotinic cholinergic receptors labeled by [3H]acetylcholine on catecholamine and serotonin axons in brain. 
  • Pretreatment cytokinetic studies in 94 children with acute leukemia. Relationship to other variables at diagnosis and to outcome of standard treatment. 
  • Principles that govern competition or co-existence in Rho-GTPase driven polarization. 
  • Probabilistic modelling for estimating gas kinetics and decompression sickness risk in pigs during H2 biochemical decompression. 
  • Probing domain interactions in soluble guanylate cyclase. 
  • Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy. 
  • Probing the architecture of the B. subtilis RNase P holoenzyme active site by cross-linking and affinity cleavage. 
  • Probing the folding and unfolding dynamics of secondary and tertiary structures in a three-helix bundle protein. 
  • Probing the interplay between the two steps of group I intron splicing: competition of exogenous guanosine with omega G. 
  • Processing of intermediates in multienzyme complexes. 
  • Processive post-translational modification. Vitamin K-dependent carboxylation of a peptide substrate. 
  • Prochelators triggered by hydrogen peroxide provide hexadentate iron coordination to impede oxidative stress. 
  • Production of superoxide anion by an NADPH-oxidase from rat pulmonary macrophages. 
  • Prolonged exposure of the HIV-1 gp41 membrane proximal region with L669S substitution. 
  • Propagation of fluctuations in biochemical systems, I: linear SSC networks. 
  • Properties and kinetic mechanism of recombinant mammalian protein geranylgeranyltransferase type I. 
  • Properties and regulation of the cell cycle-specific NIMA protein kinase of Aspergillus nidulans. 
  • Properties of a Drosophila RNA polymerase II elongation factor. 
  • Properties of mutationally altered RNA polymerases II of Drosophila. 
  • Properties of rabbit muscle phosphofructokinase modified with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole. 
  • Prostaglandins modulate hormonal effects on rabbit myometrial alpha 1-adrenergic responses. 
  • Prostate specific antigen kinetics at tumor recurrence after radical prostatectomy do not suggest a worse disease prognosis in black men. 
  • Prostate-specific antigen dynamics predict individual responses to intermittent androgen deprivation. 
  • Protease inhibitors implicate metalloendoprotease in synaptic transmission at the mammalian neuromuscular junction. 
  • Protection from nitrosative stress by yeast flavohemoglobin. 
  • Protein (serine and threonine) phosphate phosphatases. 
  • Protein alignment by a coexpressed lanthanide-binding tag for the measurement of residual dipolar couplings. 
  • Protein dynamic studies move to a new time slot. 
  • Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release. 
  • Protein folding dynamics: quantitative comparison between theory and experiment. 
  • Protein kinase A, cytosolic calcium, and phosphate uptake in human proximal renal cells. 
  • Protein kinase C activates the renal apical membrane Na+/H+ exchanger. 
  • Protein kinase C mediates cholinergically regulated protein phosphorylation in a Cl(-)-secreting epithelium. 
  • Protein kinase inhibitor in sertoli cell-enriched rat testis. Specific regulation by follicle-stimulating hormone. 
  • Protein kinetic signatures of the remodeling heart following isoproterenol stimulation. 
  • Protein kinetics: structures of intermediates and reaction mechanism from time-resolved x-ray data. 
  • Protein phosphorylation and intermolecular electron transfer: a joint experimental and computational study of a hormone biosynthesis pathway. 
  • Protein phosphorylation is a regulatory mechanism for O6-alkylguanine-DNA alkyltransferase in human brain tumor cells. 
  • Protein prenyltransferases. 
  • Protein synthesis-dependent potentiation by thyroxine of antiviral activity of interferon-gamma. 
  • Protein-protein and protein-DNA interactions at the bacteriophage T4 DNA replication fork. Characterization of a fluorescently labeled DNA polymerase sliding clamp. 
  • Protein-protein interactions contributing to the specificity of intracellular vesicular trafficking. 
  • Proteolysis of smooth muscle myosin light chain kinase. Formation of inactive and calmodulin-independent fragments. 
  • Proteolytic domains of the epidermal growth factor receptor of human placenta. 
  • Proteomic analysis of arginine adducts on glyoxal-modified ribonuclease. 
  • Protocol to measure endotoxin from opaque tissues in mice using an optimized kinetic limulus amebocyte lysate assay. 
  • Proton NMR of Escherichia coli sulfite reductase: the unligated hemeprotein subunit. 
  • Pseudomonas aeruginosa elastase degrades surfactant proteins A and D. 
  • Purification and characterization of a "half-molecule" alpha 2-macroglobulin from the southern grass frog: absence of binding to the mammalian alpha 2-macroglobulin receptor. 
  • Purification and characterization of a lecithin-D(-)- -hydroxybutyrate dehydrogenase complex. 
  • Purification and characterization of frog alpha-macroglobulin: receptor recognition of an amphibian glycoprotein. 
  • Purification and characterization of the Cu,Zn SOD from Escherichia coli. 
  • Purification and characterization of the beta-adrenergic receptor kinase. 
  • Purification and characterization of zeta-crystallin/quinone reductase from guinea pig liver. 
  • Purification and identification of two serine class proteinases from dog mast biochemically and immunologically similar to human proteinases tryptase and chymase. 
  • Purification and properties of DNA polymerase-beta from guinea pig liver. 
  • Purification and properties of EcoRI endonuclease. 
  • Purification and properties of a multifunctional calcium/calmodulin-dependent protein kinase from rat pancreas. 
  • Purification and properties of chicken liver xanthine dehydrogenase. 
  • Purification and properties of sulfite oxidase from chicken liver. Presence of molybdenum in sulfite oxidase from diverse sources. 
  • Purification and properties of the NAD+-dependent (type D) and O2-dependent (type O) forms of rat liver xanthine dehydrogenase. 
  • Purification and properties of xanthine dehydroganase from Micrococcus lactilyticus. 
  • Purification of a 12,020-dalton protein that enhances the activation of mitogen-activated protein (MAP) kinase by MAP kinase kinase. 
  • Purification of adenylosuccinate lyase from rat skeletal muscle by a novel affinity column. Stabilization of the enzyme, and effects of anions and fluoro analogues of the substrate. 
  • Purification of an active proteolytic fragment of the membrane attachment site for human erythrocyte spectrin. 
  • Purification of an almond emulsin fucosidase on Cibacron blue-sepharose and demonstration of its activity toward fucose-containing glycoproteins. 
  • Purification of replication protein C, a cellular protein involved in the initial stages of simian virus 40 DNA replication in vitro. 
  • Purification of the HhaII restriction endonuclease from an overproducer Escherichia coli clone. 
  • Purification of the beta-adrenergic receptor. Identification of the hormone binding subunit. 
  • Purine reutilization and synthesis de novo in APRT deficient long-term lymphocyte lines. 
  • Purine reutilization and synthesis de novo in long-term human lymphocyte cell lines deficient in adenine phosphoribosyltransferase activity. 
  • Pyrrole oxidation and protein cross-linking as necessary steps in the development of gamma-diketone neuropathy. 
  • Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands. 
  • Quality of potent Mn porphyrin-based SOD mimics and peroxynitrite scavengers for pre-clinical mechanistic/therapeutic purposes. 
  • Quantification of alpha4beta2* nicotinic receptors in the rat brain with microPET and 2-[18F]F-A-85380. 
  • Quantification of normal cell death in the rat retina: implications for clone composition in cell lineage analysis. 
  • Quantifying intrinsic specificity: a potential complement to affinity in drug screening. 
  • Quantifying kinetic paths of protein folding. 
  • Quantifying the kinetic paths of flexible biomolecular recognition. 
  • Quantitation and significance of 125I-calmodulin binding to myosin light chain kinase and phosphorylase distributed on polyacrylamide gels. 
  • Quantitative determination that one of two potential RNA-binding domains of the A protein component of the U1 small nuclear ribonucleoprotein complex binds with high affinity to stem-loop II of U1 RNA. 
  • Quantitative modeling of transcription factor binding specificities using DNA shape. 
  • Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer. 
  • Quenching of DNA cross-link precursors of chloroethylnitrosoureas and attenuation of DNA interstrand cross-linking by glutathione. 
  • Quiescent phenotype of tumor-specific CD8+ T cells following immunization. 
  • Quinidine blocks adenosine 5'-triphosphate-sensitive potassium channels in heart. 
  • R73A and H144Q mutants of the yeast mitochondrial cyclophilin Cpr3 exhibit a low prolyl isomerase activity in both peptide and protein-folding assays. 
  • RANBP2 is an allosteric activator of the conventional kinesin-1 motor protein, KIF5B, in a minimal cell-free system. 
  • RCC1, a regulator of mitosis, is essential for DNA replication. 
  • RGS9-G beta 5 substrate selectivity in photoreceptors. Opposing effects of constituent domains yield high affinity of RGS interaction with the G protein-effector complex. 
  • RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha. 
  • RNA polymerase B from Drosophila melanogaster larvae. Purification and partial characterization. 
  • RNase H activation by stereoregular boranophosphate oligonucleotide. 
  • Rabbit and human liver contain a novel pentacyclic triterpene ester with acyl-CoA: cholesterol acyltransferase inhibitory activity. 
  • Rac1, a low-molecular-mass GTP-binding-protein with high intrinsic GTPase activity and distinct biochemical properties. 
  • Radical decay kinetics in ferrocytochrome c model membranes. A spin label study. 
  • Radio-induced modulation of transforming growth factor beta1 sensitivity in a p53 wild-type human colorectal-cancer cell line. 
  • Radioimmunoassay for terfenadine in human plasma. 
  • Radium and barium removal through blending hydraulic fracturing fluids with acid mine drainage. 
  • Randomized COMparison of platelet inhibition with abciximab, tiRofiban and eptifibatide during percutaneous coronary intervention in acute coronary syndromes: the COMPARE trial. Comparison Of Measurements of Platelet aggregation with Aggrastat, Reopro, and Eptifibatide. 
  • Range and magnitude of the steric pressure between bilayers containing phospholipids with covalently attached poly(ethylene glycol). 
  • Rapacuronium augments acetylcholine-induced bronchoconstriction via positive allosteric interactions at the M3 muscarinic receptor. 
  • Rapid changes in light scattering from human polymorphonuclear leukocytes exposed to chemoattractants. Discrete responses correlated with chemotactic and secretory functions. 
  • Rapid clearance of virus after acute HIV-1 infection: correlates of risk of AIDS. 
  • Rapid degradation of puromycyl peptides in hepatoma cells and reticulocytes. 
  • Rapid double 8-nm steps by a kinesin mutant. 
  • Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo. 
  • Rapid in vitro assembly dynamics and subunit turnover of FtsZ demonstrated by fluorescence resonance energy transfer. 
  • Rapid in vitro assembly of Caulobacter crescentus FtsZ protein at pH 6.5 and 7.2. 
  • Rapid kinetic-based screening of human Fab fragments. 
  • Rapid memory CD8+ T-lymphocyte induction through priming with recombinant Mycobacterium smegmatis. 
  • Rapid optimization of enzyme substrates using defined substrate mixtures. 
  • Rat liver NAD(P)H:quinone oxidoreductase: cDNA expression and site-directed mutagenesis. 
  • Rates of fixation by lightning of carbon and nitrogen in possible primitive atmospheres. 
  • Rates of induction of specific translatable messenger RNAs for ovalbumin and avidin by steroid hormones. 
  • Rational design of a calcium-binding protein. 
  • Rational theophylline use in older asthmatics. 
  • Re: age-related brain cholinesterase inhibition kinetics following in vitro incubation with chlorpyrifos-oxon and diazinon-oxon. 
  • Reaction mechanism of (6-4) photolyase. 
  • Reaction mechanisms of mononuclear non-heme iron oxygenases. 
  • Reaction of N-acylhomoserine lactones with hydroxyl radicals: rates, products, and effects on signaling activity. 
  • Reaction of human alpha 2-macroglobulin half-molecules with plasmin as a probe of protease binding site structure. 
  • Reaction of human skin chymotrypsin-like proteinase chymase with plasma proteinase inhibitors. 
  • Reaction path determination for quantum mechanical/molecular mechanical modeling of enzyme reactions by combining first order and second order "chain-of-replicas" methods. 
  • Reactions of manganese porphyrins with peroxynitrite and carbonate radical anion. 
  • Reaper-induced apoptosis in a vertebrate system. 
  • Recent developments in enantioselective gold(I) catalysis. 
  • Receptor and G betagamma isoform-specific interactions with G protein-coupled receptor kinases. 
  • Receptor biophysics and biochemistry. Enzymes. 
  • Receptor class desensitization of leukocyte chemoattractant receptors. 
  • Receptor-coupled activation of phosphoinositide-specific phospholipase C by an N protein. 
  • Receptor-mediated endocytosis of carcinoembryonic antigen by rat liver Kupffer cells. 
  • Receptors on hepatocytes that bind ligands containing fucosyl alpha 1,3 N-acetylglucosamine linkages. 
  • Recombinant human acid alpha-glucosidase corrects acid alpha-glucosidase-deficient human fibroblasts, quail fibroblasts, and quail myoblasts. 
  • Recombinant immunotoxin containing a disulfide-stabilized Fv directed at erbB2 that does not require proteolytic activation. 
  • Reconstitution of Ca(2+)-dependent K+ transport in erythrocyte membrane vesicles requires a cytoplasmic protein. 
  • Reconstitution of a hormone-sensitive adenylate cyclase system. The pure beta-adrenergic receptor and guanine nucleotide regulatory protein confer hormone responsiveness on the resolved catalytic unit. 
  • Reconstitution of beta-adrenergic receptors in lipid vesicles: affinity chromatography-purified receptors confer catecholamine responsiveness on a heterologous adenylate cyclase system. 
  • Reconstitution of cAMP-dependent protein kinase regulated renal Na+-H+ exchanger. 
  • Reconstitution of nuclear protein export in isolated nuclear envelopes. 
  • Reconstitution of protein translocation from detergent-solubilized Escherichia coli inverted vesicles: PrlA protein-deficient vesicles efficiently translocate precursor proteins. 
  • Red blood cell arginase suppresses Jurkat (T cell) proliferation by depleting arginine. 
  • Redistribution of protein kinase C activity in human monocytes: correlation with activation of the respiratory burst. 
  • Redox modulation of oxidative stress by Mn porphyrin-based therapeutics: the effect of charge distribution. 
  • Redox potential determines the reaction mechanism of HNO donors with Mn and Fe porphyrins: defining the better traps. 
  • Redox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobin. 
  • Redox properties of human transferrin bound to its receptor. 
  • Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. 3. The Escherichia coli hemoflavoprotein: catalytic parameters and the sequence of electron flow. 
  • Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. V. Studies with the Escherichia coli hemoflavoprotein depleted of flavin mononucleotide: distinct roles for the flavin adenine dinucleotide and flavin mononucleotide prosthetic groups in catalysis. 
  • Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. VI. The reaction of carbon monoxide with the Escherichia coli holoenzyme, the hemoprotein, and free siroheme. 
  • Regional localization of a glioma-associated antigen defined by monoclonal antibody 81C6 in vivo: kinetics and implications for diagnosis and therapy. 
  • Regional measurements of blood-to-tissue transport in experimental RG-2 rat gliomas. 
  • Regionally distinct stoichiometry for N-methyl-D-aspartate receptor domains in brain. 
  • Regions of the 110-kDa regulatory subunit M110 required for regulation of myosin-light-chain-phosphatase activity in smooth muscle. 
  • Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function. 
  • Regulation of T cell receptor- and CD28-induced tyrosine phosphorylation of the focal adhesion tyrosine kinases Pyk2 and Fak by protein kinase C. A role for protein tyrosine phosphatases. 
  • Regulation of adenylate cyclase coupled beta-adrenergic receptors. 
  • Regulation of adrenergic receptor function by phosphorylation. I. Agonist-promoted desensitization and phosphorylation of alpha 1-adrenergic receptors coupled to inositol phospholipid metabolism in DDT1 MF-2 smooth muscle cells. 
  • Regulation of arrestin-3 phosphorylation by casein kinase II. 
  • Regulation of beta-adrenergic receptors by guanyl-5'-yl imidodiphosphate and other purine nucleotides. 
  • Regulation of biliary protein secretion in dogs. 
  • Regulation of brain ornithine decarboxylase activity in the neonatal rat. 
  • Regulation of de novo purine biosynthesis in human lymphoblasts. Coordinate control of proximal (rate-determining) steps and the inosinic acid branch point. 
  • Regulation of de novo purine synthesis in human lymphoblasts. Similar rates of de novo synthesis during growth by normal cells and mutants deficient in hypoxanthine-guanine phosphoribosyltransferase activity. 
  • Regulation of deactivation of photoreceptor G protein by its target enzyme and cGMP. 
  • Regulation of enzyme activity. The activity of enzymes can be controlled by a multiplicity of conformational equilibria. 
  • Regulation of epithelial chloride channels by protein phosphatase. 
  • Regulation of factor IXa in vitro in human and mouse plasma and in vivo in the mouse. Role of the endothelium and the plasma proteinase inhibitors. 
  • Regulation of factor Xa in vitro in human and mouse plasma and in vivo in mouse. Role of the endothelium and plasma proteinase inhibitors. 
  • Regulation of gonadotropin-releasing hormone secretion by cannabinoids. 
  • Regulation of hormone receptors and adenylyl cyclases by guanine nucleotide binding N proteins. 
  • Regulation of intestinal cholecystokinin and somatostatin mRNA by bombesin in rats. 
  • Regulation of intracellular levels of calmodulin and tubulin in normal and transformed cells. 
  • Regulation of local GTP availability controls RAC1 activity and cell invasion. 
  • Regulation of lysyl oxidase mRNA in dermal fibroblasts from normal donors and patients with inherited connective tissue disorders. 
  • Regulation of membrane chloride currents in rat bile duct epithelial cells. 
  • Regulation of membrane release in apoptosis. 
  • Regulation of nitric oxide synthesis by oxygen in vascular endothelial cells. 
  • Regulation of ornithine decarboxylase activity in the developing heart of euthyroid or hyperthyroid rats. 
  • Regulation of phosphatidate phosphatase activity from the yeast Saccharomyces cerevisiae by sphingoid bases. 
  • Regulation of plasminogen activation by components of the extracellular matrix. 
  • Regulation of prostaglandin receptors by prostaglandins and guanine nucleotides in frog erythrocytes. 
  • Regulation of rabbit myometrial alpha adrenergic receptors by estrogen and progesterone. 
  • Regulation of receptor function by protein phosphorylation. 
  • Regulation of ribosomal protein synthesis in an Escherichia coli mutant missing ribosomal protein L1. 
  • Regulation of the uncoupling protein gene (Ucp) by beta 1, beta 2, and beta 3-adrenergic receptor subtypes in immortalized brown adipose cell lines. 
  • Regulation of transducin GTPase activity in bovine rod outer segments. 
  • Regulation of transmembrane signaling by receptor phosphorylation. 
  • Regulatory mechanisms of a chemoattractant receptor on leukocytes. 
  • Reinterpretation of GCN4-p1 folding kinetics: partial helix formation precedes dimerization in coiled coil folding. 
  • Relationship between insulin-mediated turnover of glucosamine-labeled lipids and activity of the insulin receptor tyrosine kinase. 
  • Relative Contributions of Copper Oxide Nanoparticles and Dissolved Copper to Cu Uptake Kinetics of Gulf Killifish (Fundulus grandis) Embryos. 
  • Relative quantification based on logistic models for individual polymerase chain reactions. 
  • Relaxation spectra of adenosine triphosphate-creatine phosphotransferase. 
  • Relaxation spectra of aspartate transcarbamylase. I. Interaction of 5-bromocytidine triphosphate with native enzyme and regulatory subunit. 
  • Relaxation spectra of aspartate transcarbamylase. Interaction of the catalytic subunit with carbamyl phosphate, succinate, and L-malate. 
  • Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with an adenosine 5'-triphosphate analog. 
  • Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with aspartate analogs. 
  • Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with carbamyl phosphate. 
  • Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with cytidine 5'-triphosphate. 
  • Relaxation spectra of enzymatic reactions. 
  • Relaxation spectra of ribonuclease. VII. The interaction of ribonuclease with uridine 2',3'-cyclic phosphate. 
  • Relaxation spectrometry of biological systems. 
  • Release and activity of anti-TNFalpha therapeutics from injectable chitosan preparations for local drug delivery. 
  • Release of amino-terminal fragments from amyloid precursor protein reporter and mutated derivatives in cultured cells. 
  • Release of arachidonate from membrane phospholipids in cultured neonatal rat myocardial cells during adenosine triphosphate depletion. Correlation with the progression of cell injury. 
  • Release of ubiquitin-charged Cdc34-S - Ub from the RING domain is essential for ubiquitination of the SCF(Cdc4)-bound substrate Sic1. 
  • Reliability of isokinetic muscle strength testing in 45- to 78-year-old men and women. 
  • Removal of 2-MIB and geosmin using UV/persulfate: contributions of hydroxyl and sulfate radicals. 
  • Removal of phosphorylation sites from the beta 2-adrenergic receptor delays onset of agonist-promoted desensitization. 
  • Renal and hepatic lysosomal catabolism of luteinizing hormone. 
  • Repair of the Escherichia coli chromosome after in vivo scission by the EcoRI endonuclease. 
  • Repeated seizures induce long-term increase in hippocampal benzodiazepine receptors. 
  • Reproducibility of the pharmacokinetic-hemodynamic response to nitroglycerin in the dog: a model for studying the effects of chronic treatment. 
  • Repulsive expansion dynamics in colony growth and gene expression. 
  • Repurposing an endogenous degradation system for rapid and targeted depletion of C. elegans proteins. 
  • Resolving fast and slow motions in the internal loop containing stem-loop 1 of HIV-1 that are modulated by Mg2+ binding: role in the kissing-duplex structural transition. 
  • Resonating to the music of ubiquitination. 
  • Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs. 
  • Results of minimally toxic nonmyeloablative transplantation in patients with sickle cell anemia and beta-thalassemia. 
  • Retina-specifically expressed novel subtypes of bovine cyclophilin. 
  • Retinoic acid modulation of alpha(1-->2) fucosyltransferase activity and sensitivity of tumor cells to LAK-mediated cytotoxicity. 
  • Retrograde axonal transport of locally synthesized phosphoinositides in the rat sciatic nerve. 
  • Reversal of carbon monoxide-cytochrome c oxidase binding by hyperbaric oxygen in vivo. 
  • Reversible binding of platelet-derived growth factor-AA, -AB, and -BB isoforms to a similar site on the "slow" and "fast" conformations of alpha 2-macroglobulin. 
  • Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper. 
  • Reversible uncoupling of oxidative phosphorylation at low oxygen tension. 
  • Reversibly cross-linked surface-grafted polymer brushes. 
  • Reversing established sepsis with antagonists of endogenous high-mobility group box 1. 
  • Reversion from deficiency of galactose-1-phosphate uridylytransferase (GALT) in an SV40-transformed human fibroblast line. 
  • Ribozyme cleavage of a 2,5-phosphodiester linkage: mechanism and a restricted divalent metal-ion requirement. 
  • Ring current effects in adriamycin-flavin mononucleotide complexation as observed by 1H FT NMR spectroscopy. 
  • Robust, linear correlations between growth rates and β-lactam-mediated lysis rates. 
  • Robustness of MetaNet graph models: predicting control of urea production in humans. 
  • Role of aggregated human growth hormone (hGH) in development of antibodies to hGH. 
  • Role of arginine 180 and glutamic acid 177 of ricin toxin A chain in enzymatic inactivation of ribosomes. 
  • Role of aspartic acid 38 in the cofactor specificity of Drosophila alcohol dehydrogenase. 
  • Role of autophosphorylation in regulating calmodulin-dependent protein kinases. 
  • Role of citrate and phosphate anions in the mechanism of iron(III) sequestration by ferric binding protein: kinetic studies of the formation of the holoprotein of wild-type FbpA and its engineered mutants. 
  • Role of complement C9 and calcium in the generation of arachidonic acid and its metabolites from rat polymorphonuclear leukocytes. 
  • Role of conserved residues within the carboxy phosphate domain of carbamoyl phosphate synthetase. 
  • Role of conserved tyrosine 343 in intramolecular electron transfer in human sulfite oxidase. 
  • Role of extracellular disulfide-bonded cysteines in the ligand binding function of the beta 2-adrenergic receptor. 
  • Role of membrane curvature in mechanoelectrical transduction: ion carriers nonactin and valinomycin sense changes in integral bending energy. 
  • Role of phospholipase Cbeta3 phosphorylation in the desensitization of cellular responses to platelet-activating factor. 
  • Role of repulsive factors in vascularization dynamics. 
  • Role of residue 147 in the gene regulatory function of the Escherichia coli purine repressor. 
  • Role of the membrane cortex in neutrophil deformation in small pipets. 
  • Roles of the AMP-activated and cyclic-AMP-dependent protein kinases in the adrenaline-induced inactivation of acetyl-CoA carboxylase in rat adipocytes. 
  • S-Adenosylhomocysteine hydrolase from human placenta. Affinity purification and characterization. 
  • S-Nitrosohemoglobin is unstable in the reductive erythrocyte environment and lacks O2/NO-linked allosteric function. 
  • S-adenosylhomocysteine hydrolase is an adenosine-binding protein: a target for adenosine toxicity. 
  • STAT3-mediated attenuation of CCl4-induced mouse liver fibrosis by the protein kinase inhibitor sorafenib. 
  • Sagittal plane kinematics predict kinetics during walking gait in individuals with anterior cruciate ligament reconstruction. 
  • Saturation mutagenesis of His114 of EcoRI reveals relaxed-specificity mutants. 
  • Schedule-dependent enhancement of 1-beta-D-arabinofuranosylcytosine incorporation into HL-60 DNA by deoxyguanosine. 
  • Seasonal variation in body mass and locomotor kinetics of the fat-tailed dwarf lemur (Cheirogaleus medius). 
  • Secondary structure of a leucine zipper determined by nuclear magnetic resonance spectroscopy. 
  • Secondary structure of ovalbumin messenger RNA. 
  • Secondary structure of the self-cleaving RNA of hepatitis delta virus: applications to catalytic RNA design. 
  • Secretin receptors in a new preparation of plasma membranes from intrahepatic biliary epithelium. 
  • Sel-association of glucagon. Equilibrium studies. 
  • Selection of heptapeptides that bind helix 69 of bacterial 23S ribosomal RNA. 
  • Selection of novel affinity-matured human chondroitin sulfate proteoglycan 4 antibody fragments by yeast display. 
  • Selective association of spectrin with the cytoplasmic surface of human erythrocyte plasma membranes. Quantitative determination with purified (32P)spectrin. 
  • Selective diminution of the binding of mannose by murine macrophages in the late stages of activation. 
  • Selective mutations in cloned and expressed alpha-macroglobulin receptor binding fragment alter binding to either the alpha2-macroglobulin signaling receptor or the low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor. 
  • Selective regulation of expression of protein kinase C beta isoenzymes occurs via alternative splicing. 
  • Selectivity and stereospecificity of the reactions of dichlorodiammineplatinum(II) with three purified plasma proteins. 
  • Selenite binding to carbon monoxide oxidase from Pseudomonas carboxydovorans. Selenium binds covalently to the protein and activates specifically the CO----methylene blue reaction. 
  • Self-interaction-free exchange-correlation functional for thermochemistry and kinetics. 
  • Sensitivity analysis of a model of mammalian neural membrane. 
  • Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimal and noninvasive probes for hepatic and first-pass CYP3A induction. 
  • Sensitization of frog erythrocyte adenylate cyclase system by tumor-promoting phorbol diesters. 
  • Separation and quantitation of serum constituents associated with calcium by gel filtration. 
  • Separation of solubilized alpha and beta adrenergic receptors by affinity chromatography. 
  • Septin complexes assemble during a kinetic window of opportunity. 
  • Sequence complexity of nuclear and cytoplasmic ribonucleic acids from clonal neurotumor cell lines and brain sections of the rat. 
  • Sequential synthesis of small capped RNA transcripts in vitro by vesicular stomatitis virus. 
  • Serotonin synthesis, release and reuptake in terminals: a mathematical model. 
  • Serum concentrations of deoxycorticosterone in women during the luteal phase of the ovarian cycle are not suppressed by dexamethasone treatment. 
  • Serum withdrawal induces apoptotic cell death in Ki-ras transformed but not in normal differentiated thyroid cells. 
  • Severe theophylline toxicity. Role of conservative measures, antiarrhythmic agents, and charcoal hemoperfusion. 
  • Shape-Dependent Surface Reactivity and Antimicrobial Activity of Nano-Cupric Oxide. 
  • Short chain fatty acids increase prolactin and growth hormone production and alter cell morphology in the GH3 strain of rat pituitary cells. 
  • Short-lived alpha-helical intermediates in the folding of beta-sheet proteins. 
  • Short-term N2 fixation kinetics in a moss-associated cyanobacteria 
  • Short-term kinetics of tumor antigen expression in response to vaccination. 
  • Shortening the HIV-1 TAR RNA Bulge by a Single Nucleotide Preserves Motional Modes over a Broad Range of Time Scales. 
  • Sialic acid content of plasminogen 2 glycoforms as a regulator of fibrinolytic activity. Isolation, carbohydrate analysis, and kinetic characterization of six glycoforms of plasminogen. 
  • Signal discretization: a source of error in histograms of ion channel events. 
  • Simian virus 40 transcriptional complexes incorporate mercurated nucleotides into RNA in vitro. 
  • Simple biochemical pathways far from steady state can provide switchlike and integrated responses. 
  • Simulated actin reorganization mediated by motor proteins. 
  • Single- and dual-fractal analysis of hybridization binding kinetics: biosensor applications. 
  • Single-molecule FRET reveals multiscale chromatin dynamics modulated by HP1α. 
  • Single-molecule and transient kinetics investigation of the interaction of dihydrofolate reductase with NADPH and dihydrofolate. 
  • Site-directed mutagenesis in the effector site of Escherichia coli phosphofructokinase. 
  • Site-directed mutagenesis of glycine-14 and two "critical" cysteinyl residues in Drosophila alcohol dehydrogenase. 
  • Site-directed mutagenesis of recombinant sulfite oxidase: identification of cysteine 207 as a ligand of molybdenum. 
  • Site-specific mutagenesis of Drosophila alcohol dehydrogenase: evidence for involvement of tyrosine-152 and lysine-156 in catalysis. 
  • Site-specific recognition of bacteriophage T4 DNA by T4 type II DNA topoisomerase and Escherichia coli DNA gyrase. 
  • Sites of interaction between rod G-protein alpha-subunit and cGMP-phosphodiesterase gamma-subunit. Implications for the phosphodiesterase activation mechanism. 
  • Skp2 deficiency inhibits chemical skin tumorigenesis independent of p27(Kip1) accumulation. 
  • Slow NMDA-EPSCs at synapses critical for song development are not required for song learning in zebra finches. 
  • Sodium channel kinetic changes that produce Brugada syndrome or progressive cardiac conduction system disease. 
  • Sodium dodecyl sulfate-stable complexes between serpins and active or inactive proteinases contain the region COOH-terminal to the reactive site loop. 
  • Sodium-dependent proline and glutamate uptake by hippocampal synaptosomes during postnatal development. 
  • Sodium-independent binding of L-[3H]proline to hippocampal synaptic membranes. 
  • Solid-phase synthesis for the identification of high-affinity bivalent lectin ligands. 
  • Solubilization and characterization of the beta-adrenergic receptor binding sites of frog erythrocytes. 
  • Solubilization and reconstitution of renal brush border Na+-H+ exchanger. 
  • Solubilization of a [3H]cimetidine binding site from rat brains. A clonidine-sensitive H-2 receptor subtype? 
  • Solubilization of rat liver alpha 1-adrenergic receptors. Agonist specific alteration in receptor binding affinity. 
  • Solubilization of tricalcium phosphate by P(3HB) accumulating Azotobacter chroococcum MAL-201. 
  • Solvent dependence of intramolecular electron transfer in a helical oligoproline assembly. 
  • Somatostatin induces translocation of the beta-adrenergic receptor kinase and desensitizes somatostatin receptors in S49 lymphoma cells. 
  • Sorting of lipids and transmembrane peptides between detergent-soluble bilayers and detergent-resistant rafts. 
  • Spatial relationships between specific sites on reconstituted chloroplast proton adenosinetriphosphatase and the phospholipid vesicle surface. 
  • Specific 33-residue repeat(s) of erythrocyte ankyrin associate with the anion exchanger. 
  • Specific association of retroviral envelope protein, p15E, with human cell surfaces. 
  • Specific binding of RGS9-Gbeta 5L to protein anchor in photoreceptor membranes greatly enhances its catalytic activity. 
  • Specific binding of urinary-type plasminogen activator (u-PA) to vitronectin and its role in mediating u-PA-dependent adhesion of U937 cells. 
  • Specific blockers of myoblast fusion inhibit a soluble and not the membrane-associated metalloendoprotease in myoblasts. 
  • Specific interaction of 3H-FSH with rat testis binding sites. 
  • Specific peptide probes for G-protein interaction with effectors. 
  • Specific receptor sites for chemotactic peptides on human polymorphonuclear leukocytes. 
  • Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles. 
  • Spectroelectrochemistry of heme proteins: effects of active-site heterogeneity on Nernst plots. 
  • Spectroscopic studies of the molybdenum-containing dimethyl sulfoxide reductase from Rhodobacter sphaeroides f. sp. denitrificans. 
  • Spermine. A regulator of mitochondrial calcium cycling. 
  • Sphingosine inhibits monocyte tissue factor-initiated coagulation by altering factor VII binding. 
  • Spinach siroheme enzymes: Isolation and characterization of ferredoxin-sulfite reductase and comparison of properties with ferredoxin-nitrite reductase. 
  • Spontaneous formation of germinal centers in autoimmune mice. 
  • Spot hemoglobin. Studies on the Root effect hemoglobin of a marine teleost. 
  • Stable docking of neutralizing human immunodeficiency virus type 1 gp41 membrane-proximal external region monoclonal antibodies 2F5 and 4E10 is dependent on the membrane immersion depth of their epitope regions. 
  • Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein. 
  • Staphylococcus aureus sortase transpeptidase SrtA: insight into the kinetic mechanism and evidence for a reverse protonation catalytic mechanism. 
  • Statistical comparison between dissolution profiles of drug products. 
  • Steady state kinetic studies of purified yeast plasma membrane proton-translocating ATPase. 
  • Steady state kinetics of ATP synthesis and hydrolysis catalyzed by reconstituted chloroplast coupling factor. 
  • Steady state kinetics of soluble and membrane-bound mitochondrial ATPase. 
  • Steady-state kinetic study of fatty acid synthase from chicken liver. 
  • Steady-state kinetic study of rabbit muscle phosphofructokinase. 
  • Steering electrons on moving pathways. 
  • Stepping-stone spatial structure causes slow decay of linkage disequilibrium and shifts the site frequency spectrum. 
  • Stereochemistry and mechanism of the Brønsted acid catalyzed intramolecular hydrofunctionalization of an unactivated cyclic alkene. 
  • Stereospecific (3H)(minus)-alprenolol binding sites, beta-adrenergic receptors and adenylate cyclase. 
  • Stereospecificity and kinetic mechanism of human prenylcysteine lyase, an unusual thioether oxidase. 
  • Steric repulsion between phosphatidylcholine bilayers. 
  • Stimulation of cytoplasmic actin gene transcription and translation in cultured Drosophila cells by ecdysterone. 
  • Stimulation of glucose-6-phosphatase gene expression by glucose and fructose-2,6-bisphosphate. 
  • Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1. 
  • Stimulation of insulin secretion by a rapid intravenous calcium infusion in patients with beta-cell neoplasms of the pancreas. 
  • Stimulation of rat heart ornithine decarboxylase by isoproterenol evidence for post-translational control of enzyme activity? 
  • Strain variation and morphogenesis of yeast- and mycelial-phase Candida albicans in low-sulfate, synthetic medium. 
  • Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines. 
  • Stretch and poke stimulation for characterizing mechanically activated ion channels. 
  • Strong Binding of Platelet Integrin αIIbβ3 to Fibrin Clots: Potential Target to Destabilize Thrombi. 
  • Strong means slow: dynamic contributions to the bulk mechanical properties of supramolecular networks. 
  • Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis. 
  • Structural analyses of Ca²⁺/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation. 
  • Structural and Functional Characterization of Sulfonium Carbon-Oxygen Hydrogen Bonding in the Deoxyamino Sugar Methyltransferase TylM1. 
  • Structural and functional analyses of microbial metabolic networks reveal novel insights into genome-scale metabolic fluxes. 
  • Structural and functional analysis of the spontaneous re-formation of the thiol ester bond in human alpha 2-macroglobulin, rat alpha 1-inhibitor-3 and chemically modified derivatives. 
  • Structural and functional characterization of the purified cardiac ryanodine receptor-Ca2+ release channel complex. 
  • Structural and functional properties of cytochrome c oxidases isolated from sharks. 
  • Structural and mechanistic studies of the alpha-ketoglutarate dehydrogenase multienzyme complex from Escherichia coli. 
  • Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor. 
  • Structural basis for the remarkable stability of Bacillus subtilis lipase (Lip A) at low pH. 
  • Structural basis of lipid binding for the membrane-embedded tetraacyldisaccharide-1-phosphate 4'-kinase LpxK. 
  • Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters. 
  • Structural characteristics for inhibition of [3H] norepinephrine uptake into rat brain synaptic vesicles by beta-carboline, indolealkylamine, phenethylamine and n-alkylamine derivatives. 
  • Structural differences in the chromatin from compartmentalized cells of the sea urchin embryo: differential nuclease accessibility of micromere chromatin. 
  • Structural domains that contribute to substrate specificity in facilitated glucose transporters are distinct from those involved in kinetic function: studies with GLUT-1/GLUT-2 chimeras. 
  • Structural investigation of reconstituted chloroplast ATPase with fluorescence measurements. 
  • Structural map of the dicyclohexylcarbodiimide site of chloroplast coupling factor determined by resonance energy transfer. 
  • Structural mapping of rabbit muscle phosphofructokinase. Distance between the adenosine cyclic 3',5'-phosphate binding site and a reactive sulfhydryl group. 
  • Structural properties of an active form of rabbit muscle phosphofructokinase. 
  • Structural requirements for high affinity ligand binding by estrogen receptors: a comparative analysis of truncated and full length estrogen receptors expressed in bacteria, yeast, and mammalian cells. 
  • Structure and filament dynamics of the pSK41 actin-like ParM protein: implications for plasmid DNA segregation. 
  • Structure and function of cholera toxin and hormone receptors. 
  • Structure and hydride transfer mechanism of a moderate thermophilic dihydrofolate reductase from Bacillus stearothermophilus and comparison to its mesophilic and hyperthermophilic homologues. 
  • Structure and stability of monomeric lambda repressor: NMR evidence for two-state folding. 
  • Structure, function, and assembly in the hemocyanin system of the scorpion, Androctonus australis. 
  • Structure-activity relationships of adenylate cyclase-coupled beta adrenergic receptors: determination by direct binding studies. 
  • Structure-activity relationships of noreperidine congeners on cholinesterase systems in vitro and analgesia in vivo. 
  • Structures and mechanisms of DNA restriction and modification enzymes. 
  • Structures of the Bacillus subtilis glutamine synthetase dodecamer reveal large intersubunit catalytic conformational changes linked to a unique feedback inhibition mechanism. 
  • Structures of the siroheme- and Fe4S4-containing active center of sulfite reductase in different states of oxidation: heme activation via reduction-gated exogenous ligand exchange. 
  • Studies of aldehyde oxidase by electron paramagnetic resonance spectroscopy. II. Kinetic studies by rapid freezing. 
  • Studies of the phosphoenzyme intermediate of the yeast plasma membrane proton-translocating ATPase. 
  • Studies on DNA replication in the bacteriophage T4 in vitro system. 
  • Studies on sequence recognition by type II restriction and modification enzymes. 
  • Studies on the biosynthesis of laminin by murine parietal endoderm cells. 
  • Studies on the biosynthesis of the lipodepsipeptide antibiotic Ramoplanin A2. 
  • Studies on the dissociation of flavin adenine dinucleotide from metalloflavoproteins. 
  • Studies on the function of the non-primer tRNAs associated with the 70 S RNA of avian myeloblastosis virus. 
  • Studies on the mechanism by which exogenous glucose is converted into liver glycogen in the rat. A direct or an indirect pathway? 
  • Studies on the zinc content of Cd-induced thionein. 
  • Study of the interaction of adenylyl imidodiphosphate with rabbit muscle phosphofructokinase. 
  • Study of the kinetic and physical properties of the orotidine-5'-monophosphate decarboxylase domain from mouse UMP synthase produced in Saccharomyces cerevisiae. 
  • Submillisecond folding of monomeric lambda repressor. 
  • Substitution of an extracellular cysteine in the beta 2-adrenergic receptor enhances agonist-promoted phosphorylation and receptor desensitization. 
  • Substitution of cadmium for zinc in farnesyl:protein transferase alters its substrate specificity. 
  • Substrate binding is required for release of product from mammalian protein farnesyltransferase. 
  • Substrate dependence of the mechanism of EcoRI endonuclease. 
  • Substrate length requirements for efficient mitotic recombination in Saccharomyces cerevisiae. 
  • Substrate-dependent activation energy of the reaction catalyzed by monoamine oxidase. 
  • Suicide substrates for the alanine racemase of Escherichia coli B. 
  • SulA inhibits assembly of FtsZ by a simple sequestration mechanism. 
  • Sulfate as a synergistic anion facilitating iron binding by the bacterial transferrin FbpA: the origins and effects of anion promiscuity. 
  • Suprastructures and dynamic properties of Mycobacterium tuberculosis FtsZ. 
  • Surface-bound iron: a metal ion buffer in the marine brown alga Ectocarpus siliculosus? 
  • Surface-dependent hemostasis. 
  • Surfactant apoprotein in adult rat lung compartments is increased by dexamethasone. 
  • Sustained release of BMP-2 in a lipid-based microtube vehicle. 
  • Synaptic cleft acidification and modulation of short-term depression by exocytosed protons in retinal bipolar cells. 
  • Synaptic vesicles isolated from rat heart: l-[3H]norepinephrine uptake properties. 
  • Syncatalytic modification of chicken liver xanthine dehydrogenase by hydrogen peroxide. The nature of the reaction. 
  • Synergistic induction of mitogen-activated protein kinase phosphatase-1 by thrombin and epidermal growth factor requires vascular endothelial growth factor receptor-2. 
  • Synergistic regulation of beta2-adrenergic receptor sequestration: intracellular complement of beta-adrenergic receptor kinase and beta-arrestin determine kinetics of internalization. 
  • Synthesis and characterization of a thermally-responsive tumor necrosis factor antagonist. 
  • Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1. 
  • Synthesis and proteasome inhibition of lithocholic acid derivatives. 
  • Synthesis of (3H)DNA complementary to ovalbumin messenger RNA: evidence for limited copies of the ovalbumin gene in chick oviduct. 
  • Synthesis of 5-(1-propynyl)-2'-deoxyuridine 5'-(alpha-P-borano)triphosphate and kinetic characterization as a substrate for mmlv reverse transcriptase. 
  • Synthesis of alpha 2-macroglobulin by bovine adrenal cortical cell cultures. 
  • Synthesis, characterization, and cyclic stress-influenced degradation of a poly(ethylene glycol)-based poly(beta-amino ester). 
  • Synthetic peptides of the hamster beta 2-adrenoceptor as substrates and inhibitors of the beta-adrenoceptor kinase. 
  • T cell receptor binding kinetics and special role of Valpha in T cell development and activation. 
  • T-lymphocyte alloresponses of Campath-1H-treated kidney transplant patients. 
  • T7-induced DNA polymerase. Requirement for thioredoxin sulfhydryl groups. 
  • TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin. 
  • TRPC3 channels confer cellular memory of recent neuromuscular activity. 
  • Targeted gene replacement demonstrates that myristoyl-CoA: protein N-myristoyltransferase is essential for viability of Cryptococcus neoformans. 
  • Targeted overexpression of noncleavable and secreted forms of tumor necrosis factor provokes disparate cardiac phenotypes. 
  • Targeting Gbeta gamma signaling in arterial vascular smooth muscle proliferation: a novel strategy to limit restenosis. 
  • Tau protein binding forms a 1 nm thick layer along protofilaments without affecting the radial elasticity of microtubules. 
  • Temperature dependence of the repulsive pressure between phosphatidylcholine bilayers. 
  • Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain. 
  • Temperature-jump study of the interaction of rabbit muscle phosphofructokinase with adenylyl imidodiphosphate and adenosine 5'-triphosphate. 
  • Temperature-sensitive hydrogels with SiO2-Au nanoshells for controlled drug delivery. 
  • Temporal creatine kinase curves in acute myocardial infarction. Implications of a good empiric fit with the log-normal function. 
  • Temporally distinct and ligand-specific recruitment of nuclear receptor-interacting peptides and cofactors to subnuclear domains containing the estrogen receptor. 
  • Temporally regulated nuclear entry of the Drosophila period protein contributes to the circadian clock. 
  • Ternary complex formation facilitates a redox mechanism for iron release from a siderophore. 
  • Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding. 
  • Tetrahydrobiopterin rapidly reduces the SOD mimic Mn(III) ortho-tetrakis(N-ethylpyridinium-2-yl)porphyrin. 
  • The ANK repeats of erythrocyte ankyrin form two distinct but cooperative binding sites for the erythrocyte anion exchanger. 
  • The AUXIN BINDING PROTEIN 1 is required for differential auxin responses mediating root growth. 
  • The C-terminal domain of the adenine-DNA glycosylase MutY confers specificity for 8-oxoguanine.adenine mispairs and may have evolved from MutT, an 8-oxo-dGTPase. 
  • The Chloroplast Tubulin Homologs FtsZA and FtsZB from the Red Alga Galdieria sulphuraria Co-assemble into Dynamic Filaments. 
  • The DNA helicase activities of Rad3 protein of Saccharomyces cerevisiae and helicase II of Escherichia coli are differentially inhibited by covalent and noncovalent DNA modifications. 
  • The Drosophila claret segregation protein is a minus-end directed motor molecule. 
  • The F220C and F45L rhodopsin mutations identified in retinitis pigmentosa patients do not cause pathology in mice. 
  • The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis. 
  • The MEK pathway is required for stimulation of p21(WAF1/CIP1) by transforming growth factor-beta. 
  • The N2-ethylguanine and the O6-ethyl- and O6-methylguanine lesions in DNA: contrasting responses from the "bypass" DNA polymerase eta and the replicative DNA polymerase alpha. 
  • The NADPH oxidase of human polymorphonuclear leukocytes. Evidence for regulation by multiple signals. 
  • The Tetrahymena ribozyme acts like an RNA restriction endonuclease. 
  • The alpha-helical domain of Galphat determines specific interaction with regulator of G protein signaling 9. 
  • The anion exchanger and Na+K(+)-ATPase interact with distinct sites on ankyrin in in vitro assays. 
  • The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus. 
  • The beta-adrenergic receptor and adenylate cyclase. 
  • The beta-adrenergic receptor kinase: role in homologous desensitization in S49 lymphoma cells. 
  • The beta-adrenergic receptor. 
  • The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase. 
  • The biological significance of substrate inhibition: a mechanism with diverse functions. 
  • The calmodulin binding domain of chicken smooth muscle myosin light chain kinase contains a pseudosubstrate sequence. 
  • The cardiac Na+-Ca2+ exchanger binds to the cytoskeletal protein ankyrin. 
  • The cardiac beta-adrenergic receptor. Structural similarities of beta 1 and beta 2 receptor subtypes demonstrated by photoaffinity labeling. 
  • The case of the missing NO-hemoglobin: spectral changes suggestive of heme redox reactions reflect changes in NO-heme geometry. 
  • The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes. 
  • The chemical biology of nitric oxide: implications in cellular signaling. 
  • The chromaffin granule as a model for membrane fusion: implications for exocytosis. 
  • The clearance of a monoclonal anti-DNA antibody following administration of DNA in normal and autoimmune mice. 
  • The clearance of glycoproteins in diabetic mice. 
  • The clearance of human fibrinogen fragments D1, D2, D3 and fibrin fragment D1 dimer in mice. 
  • The constitutive secretory pathway is a major route for islet amyloid polypeptide secretion in neonatal but not adult rat islet cells. 
  • The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome. 
  • The decomposition of thionitrites. 
  • The developmental switch in ventricular myosin expression in vivo is not triggered by an increase in cyclic AMP. 
  • The differential effect of in vivo hydrocortisone on the kinetics of subpopulations of human peripheral blood thymus-derived lymphocytes. 
  • The dissociation of catecholamine and hypothalamic-pituitary-adrenal responses to daily stressors using dexamethasone. 
  • The domains of rat liver sulfite oxidase. Proteolytic separation and characterization. 
  • The dynamics of ammonia metabolism in man. Effects of liver disease and hyperammonemia. 
  • The effect of active site-inhibited factor VIIa on tissue factor-initiated coagulation using platelets before and after aspirin administration. 
  • The effect of advection on the nutrient reservoir in the North Atlantic subtropical gyre. 
  • The effect of culture density and proliferation rate on the expression of ouabain-sensitive Na/K ATPase pumps in cultured human retinal pigment epithelium. 
  • The effect of divalent cations on the conformation and function of human plasminogen. 
  • The effect of fluid shear stress upon cell adhesion to fibronectin-treated surfaces. 
  • The effect of flunarizine on erythrocyte suspension viscosity under conditions of extreme hypoxia, low pH, and lactate treatment. 
  • The effect of plasmin on the subunit structure of human fibrinogen. 
  • The effect of substituted laminin A chain-derived peptides on the conformation and activation kinetics of plasminogen. 
  • The effect of transforming growth factor-beta on follicle-stimulating hormone-induced differentiation of cultured rat granulosa cells. 
  • The effector enzyme regulates the duration of G protein signaling in vertebrate photoreceptors by increasing the affinity between transducin and RGS protein. 
  • The effects of bilayer thickness and tension on gramicidin single-channel lifetime. 
  • The effects of clinically relevant hyperthermic temperatures on the kinetic binding parameters of a monoclonal antibody. 
  • The effects of food intake on muscle oxygen consumption: noninvasive measurement using NIRS. 
  • The effects of lipid composition on the binding of lasalocid A to small unilamellar vesicles. 
  • The endothelial cell protein C receptor. Cell surface expression and direct ligand binding by the soluble receptor. 
  • The energy landscape of a fast-folding protein mapped by Ala-->Gly substitutions. 
  • The evaluation of complex-dependent alterations in human factor VIIa. 
  • The evolution of control and distribution of adaptive mutations in a metabolic pathway 
  • The exposure of murine macrophages to alpha 2-macroglobulin 'fast' forms results in the rapid secretion of eicosanoids. 
  • The expression of a functional, secreted human lysyl hydroxylase in a baculovirus system. 
  • The folate cofactor of Escherichia coli DNA photolyase acts catalytically. 
  • The formylpeptide chemoattractant receptor copurifies with a GTP-binding protein containing a distinct 40-kDa pertussis toxin substrate. 
  • The gaits of primates: center of mass mechanics in walking, cantering and galloping ring-tailed lemurs, Lemur catta. 
  • The global stoichiometry of litter nitrogen mineralization. 
  • The glucose-phosphorylating capacity of liver as measured by three independent assays. Implications for the mechanism of hepatic glycogen synthesis. 
  • The hemoglobin system of the primitive fish, Amia calva: isolation and functional characterization of the individual hemoglobin components. 
  • The hepatitis delta virus large antigen is farnesylated both in vitro and in animal cells. 
  • The hierarchical assembly of septins revealed by high-speed AFM. 
  • The high Km glucose transporter of islets of Langerhans is functionally similar to the low affinity transporter of liver and has an identical primary sequence. 
  • The higher affinity of human type 1 3beta-hydroxysteroid dehydrogenase (3beta-HSD1) for substrate and inhibitor steroids relative to human 3beta-HSD2 is validated in MCF-7 tumor cells and related to subunit interactions. 
  • The human 5-HT1A receptor expressed in HeLa cells stimulates sodium-dependent phosphate uptake via protein kinase C. 
  • The human T-cell leukemia virus-1 transcriptional activator Tax enhances cAMP-responsive element-binding protein (CREB) binding activity through interactions with the DNA minor groove. 
  • The human glutathione S-transferase P1 protein is phosphorylated and its metabolic function enhanced by the Ser/Thr protein kinases, cAMP-dependent protein kinase and protein kinase C, in glioblastoma cells. 
  • The human placenta--a rich source of beta-adrenergic receptors: characterization of the receptors in particulate and solubilized preparations. 
  • The identification and characterization of a G4-DNA resolvase activity. 
  • The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model. 
  • The impact of stochastic resonance electrical stimulation and knee sleeve on impulsive loading and muscle co-contraction during gait in knee osteoarthritis. 
  • The importance of the preactivation peptide in the two-stage mechanism of human plasminogen activation. 
  • The in vivo metabolism of antithrombin III and antithrombin III complexes. 
  • The inflammatory response and resistance to endotoxin in mice. 
  • The influence of pH on th electrophysiological effects of lidocaine in guinea pig ventricular myocardium. 
  • The influence of the synergistic anion on iron chelation by ferric binding protein, a bacterial transferrin. 
  • The inoculum effect and band-pass bacterial response to periodic antibiotic treatment. 
  • The insulinomimetic effects of the polar head group of an insulin-sensitive glycophospholipid on pyruvate dehydrogenase in both subcellular and whole cell assays. 
  • The integrity of a cholesterol-binding pocket in Niemann-Pick C2 protein is necessary to control lysosome cholesterol levels. 
  • The interaction of biological and noxious transition metals with the zinc probes FluoZin-3 and Newport Green. 
  • The interaction of polyphenols with bilayers: conditions for increasing bilayer adhesion. 
  • The ionic mechanism of the slow outward current in Aplysia neurons. 
  • The kinetic mechanism of EcoRI endonuclease. 
  • The kinetic mechanism of xanthine dehydrogenase and related enzymes. 
  • The kinetics of dimethylhydroxypyridinone interactions with iron(iii) and the catalysis of iron(iii) ligand exchange reactions: implications for bacterial iron transport and combination chelation therapies. 
  • The kinetics of intramolecular distribution of 15N in uric acid after administration of (15N) glycine. A reappraisal of the significance of preferential labeling of N-(3+9) of uric acid in primary gout. 
  • The kinetics of microtubule assembly. Evidence for a two-stage nucleation mechanism. 
  • The kinetics of urinary fumonisin B1 excretion in humans consuming maize-based diets. 
  • The location of the carotenoid in the B800--850 light-harvesting pigment--protein complex from Rhodopseudomonas capsulata. 
  • The magnitude and kinetics of the mucosal HIV-specific CD8+ T lymphocyte response and virus RNA load in breast milk. 
  • The mammalian beta 2-adrenergic receptor: purification and characterization. 
  • The mammalian beta 2-adrenergic receptor: reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system. 
  • The materials engineering of temperature-sensitive liposomes. 
  • The mechanical origins of arm-swinging. 
  • The mechanical stability of ubiquitin is linkage dependent. 
  • The mechanism of action of ethanolamine ammonia-lyase, an adenosylcobalamin-dependent enzyme. Evidence that the hydrogen transfer mechanism involves a second intermediate hydrogen carrier in addition to the cofactor. 
  • The mechanisms and analysis of sperm migration through cervical mucus. 
  • The mechanisms of inactivation of sulfite oxidase by periodate and arsenite. 
  • The membrane-binding domain of ankyrin contains four independently folded subdomains, each comprised of six ankyrin repeats. 
  • The metabolic fate of independently initiated VSV mRNA transcripts. 
  • The metabolism of luteinizing hormone. Plasma clearance, urinary excretion, and tissue uptake. 
  • The moderately repetitive DNA sequences of Caenorhabditis elegans do not show short-period interspersion. 
  • The molecular basis for complexation of adriamycin with flavin mononucleotide and flavin adenine dinucleotide. 
  • The multisubunit IkappaB kinase complex shows random sequential kinetics and is activated by the C-terminal domain of IkappaB alpha. 
  • The nature of aqueous tunneling pathways between electron-transfer proteins. 
  • The negative charge of Glu-111 is required to activate the cleavage center of EcoRI endonuclease. 
  • The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits. 
  • The new cardiotonic agent sulmazole is an A1 adenosine receptor antagonist and functionally blocks the inhibitory regulator, Gi. 
  • The novel alkali tolerance function of tfxG in Sinorhizobium meliloti. 
  • The novel micro-opioid receptor antagonist, [N-allyl-Dmt(1)]endomorphin-2, attenuates the enhancement of GABAergic neurotransmission by ethanol. 
  • The oligopeptide chemotactic factor receptor on human polymorphonuclear leukocyte membranes exists in two affinity states. 
  • The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding. 
  • The ortho effect makes manganese(III) meso-tetrakis(N-methylpyridinium-2-yl)porphyrin a powerful and potentially useful superoxide dismutase mimic. 
  • The other function of DNA photolyase: stimulation of excision repair of chemical damage to DNA. 
  • The peripheral-type benzodiazepine receptor is functionally linked to Leydig cell steroidogenesis. 
  • The peritoneal cavity provides a protective niche for B1 and conventional B lymphocytes during anti-CD20 immunotherapy in mice. 
  • The pharmacokinetics of timegadine and two of its metabolites after multiple oral dosing, and the effects of concomitant administration of ibuprofen. 
  • The placental lactogen receptor in maternal and fetal sheep liver: regulation by glucose and role in the pathogenesis of fasting during pregnancy. 
  • The plant amino acid mimosine may inhibit initiation at origins of replication in Chinese hamster cells. 
  • The poly(A) site sequence in HDV RNA alters both extent and rate of self-cleavage of the antigenomic ribozyme. 
  • The rate of mitochondrial mutagenesis is faster in mice than humans. 
  • The redox hypothesis in siderophore-mediated iron uptake. 
  • The regulation of the cGMP-binding cGMP phosphodiesterase by proteins that are immunologically related to gamma subunit of the photoreceptor cGMP phosphodiesterase. 
  • The regulation of the lymphatic secretion of glucagon-like peptide-1 (GLP-1) by intestinal absorption of fat and carbohydrate. 
  • The relationship between ligand-binding thermodynamics and protein-ligand interaction forces measured by atomic force microscopy. 
  • The relationship between low density lipoprotein-related protein/alpha 2-macroglobulin (alpha 2M) receptors and the newly described alpha 2M signaling receptor. 
  • The repression of hormone-activated PEPCK gene expression by glucose is insulin-independent but requires glucose metabolism. 
  • The role of calmodulin in the structure and regulation of phosphorylase kinase from rabbit skeletal muscle. 
  • The role of carbohydrate in the function of human plasminogen: comparison of the protein obtained from molecular cloning and expression in Escherichia coli and COS cells. 
  • The role of cytoplasmic deoxycytidine kinase in the mitochondrial effects of the anti-human immunodeficiency virus compound, 2',3'-dideoxycytidine. 
  • The role of human cytochrome P450 enzymes in the formation of 2-hydroxymetronidazole: CYP2A6 is the high affinity (low Km) catalyst. 
  • The role of inactivation in open-channel block of the sodium channel: studies with inactivation-deficient mutant channels. 
  • The role of inter-alpha-trypsin inhibitor and other proteinase inhibitors in the plasma clearance of neutrophil elastase and plasmin. 
  • The role of phosphorylation/dephosphorylation of acetyl-CoA carboxylase in the regulation of mammalian fatty acid biosynthesis. 
  • The role of ribosomal subunits and 80-S monomers in polysome formation in an ascites tumour cell. 
  • The role of subunit entropy in cooperative assembly. Nucleation of microtubules and other two-dimensional polymers. 
  • The role of the calponin homology domain of smoothelin-like 1 (SMTNL1) in myosin phosphatase inhibition and smooth muscle contraction. 
  • The role of the membrane in the expression of the vitamin K-dependent enzymes. 
  • The role of the supernumerary subunit of Rhodobacter sphaeroides cytochrome bc1 complex. 
  • The role of torsion in cervical spine trauma. 
  • The role of tyrosine 343 in substrate binding and catalysis by human sulfite oxidase. 
  • The roles of alpha IIb beta 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation. 
  • The single-molecule conductance and electrochemical electron-transfer rate are related by a power law. 
  • The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation. 
  • The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse. 
  • The stoichiometry of trimeric SIV glycoprotein interaction with CD4 differs from that of anti-envelope antibody Fab fragments. 
  • The structural basis for the mutagenicity of O(6)-methyl-guanine lesions. 
  • The structural mechanism of GTP stabilized oligomerization and catalytic activation of the Toxoplasma gondii uracil phosphoribosyltransferase. 
  • The structure and function of pyruvate kinase. 
  • The structure of a CREB bZIP.somatostatin CRE complex reveals the basis for selective dimerization and divalent cation-enhanced DNA binding. 
  • The structure of a high fidelity DNA polymerase bound to a mismatched nucleotide reveals an "ajar" intermediate conformation in the nucleotide selection mechanism. 
  • The study of protein mechanics with the atomic force microscope. 
  • The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2. 
  • The surface envelope protein gene region of equine infectious anemia virus is not an important determinant of tropism in vitro. 
  • The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of ERK MAPK regulation. 
  • The temperature-dependent reaction between alpha 2-macroglobulin and streptokinase-plasmin(ogen) complex. 
  • The type I and type II bovine scavenger receptors expressed in Chinese hamster ovary cells are trimeric proteins with collagenous triple helical domains comprising noncovalently associated monomers and Cys83-disulfide-linked dimers. 
  • The unfolded protein response triggers selective mRNA release from the endoplasmic reticulum. 
  • The vibrio cholerae hybrid sensor kinase VieS contributes to motility and biofilm regulation by altering the cyclic diguanylate level. 
  • The voltage-dependent anion channel (VDAC) binds tissue-type plasminogen activator and promotes activation of plasminogen on the cell surface. 
  • The voltage-dependent anion channel is a receptor for plasminogen kringle 5 on human endothelial cells. 
  • Theoretical analysis of radioactivity profiles during fast axonal transport: effects of deposition and turnover. 
  • Theoretical and experimental determination on two substrates turned over by 4-oxalocrotonate tautomerase. 
  • Theoretical characterization of ion channel blockade. Competitive binding to periodically accessible receptors. 
  • Theoretical characterization of ion channel blockade: ligand binding to periodically accessible receptors. 
  • There is substantial agreement among interspecies estimates of DNA repair activity. 
  • Thermodynamic analysis of cyclosporin a binding to cyclophilin a in a lung tumor tissue lysate. 
  • Thermodynamic analysis of protein stability and ligand binding using a chemical modification- and mass spectrometry-based strategy. 
  • Thermodynamic and kinetic aspects of assembly. 
  • Thermodynamic constraints on the regulation of metabolic fluxes. 
  • Thermodynamic limits to the ATP/site stoichiometries of oxidative phosphorylation by rat liver mitochondria. 
  • Thermodynamic parameters governing interaction of EcoRI endonuclease with specific and nonspecific DNA sequences. 
  • Thermodynamic parameters of the alpha-methyl aspartate-aspartate aminotransferase interaction. 
  • Thermodynamics of reactions catalyzed by PABA synthase. 
  • Thermodynamics, kinetics, and mechanism of the stepwise dissociation and formation of Tris(L-lysinehydroxamato)iron(III) in aqueous acid. 
  • Three Pyrimidine Decarboxylations in the Absence of a Catalyst. 
  • Three amino acid substitutions in domain I of calmodulin prevent the activation of chicken smooth muscle myosin light chain kinase. 
  • Three-dimensional ankle kinematics and kinetics during running in women. 
  • Three-state kinetic mechanism for scaffold-mediated signal transduction. 
  • Thrombin primes responsiveness of selective chemoattractant receptors at a site distal to G protein activation. 
  • Thromboxane A2modulates the fibrinolytic system in glomerular mesangial cells. 
  • Thromboxane binding and signal transduction in rat glomerular mesangial cells. 
  • Thrombus lysis by uPA, scuPA and tPA is regulated by plasma TAFI. 
  • Thyroid Hormone Stimulation of Autophagy Is Essential for Mitochondrial Biogenesis and Activity in Skeletal Muscle. 
  • Thyroid hormone regulation of alpha-adrenergic receptors: studies in rat myocardium. 
  • Thyroid hormone regulation of beta-adrenergic receptor number. 
  • Time course and significance of changes in hepatic fructose-2,6-bisphosphate levels during refeeding of fasted rats. 
  • Time course of LPS-induced gene expression in a mouse model of genitourinary inflammation. 
  • Time-dependent inhibition of isoprenylcysteine carboxyl methyltransferase by indole-based small molecules. 
  • Time-dependent mitotic recombination in Saccharomyces cerevisiae. 
  • Time-dependent recovery of passive neutrophils after large deformation. 
  • Tissue-specific expression in mammalian brain, heart, and muscle of S1, a member of the elongation factor-1 alpha gene family. 
  • Tissue-specific expression of kallikrein-related genes in the rat. 
  • Tocainide kinetics in congestive heart failure. 
  • Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe. 
  • Total chemical synthesis and biophysical characterization of the minimal isoform of the KChIP2 potassium channel regulatory subunit. 
  • Total chemical synthesis of the B1 domain of protein L from Peptostreptococcus magnus. 
  • Tracking HLA Antibody Changes among Kidney Waitlist Candidates: One Protocol May Not Fit All. 
  • Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination. 
  • Transactivation functions facilitate the disruption of chromatin structure by estrogen receptor derivatives in vivo. 
  • Transcriptional and posttranscriptional regulation of transcription factor expression in Arabidopsis roots. 
  • Transcriptional inhibition by carcinogenic chromate: relationship to DNA damage. 
  • Transcriptional regulation of the tyrosine hydroxylase gene by glucocorticoid and cyclic AMP. 
  • Transducin and the inhibitory nucleotide regulatory protein inhibit the stimulatory nucleotide regulatory protein mediated stimulation of adenylate cyclase in phospholipid vesicle systems. 
  • Transfection efficiency and transgene expression kinetics of mRNA delivered in naked and nanoparticle format. 
  • Transfection of AtT-20ins cells with GLUT-2 but not GLUT-1 confers glucose-stimulated insulin secretion. Relationship to glucose metabolism. 
  • Transfer of human chromosomes via human minisegregant cells into mouse cells and the quantitation of the expression of hypoxanthine phosphoribosyltransferase in the hybrids. 
  • Transformation of pristine and citrate-functionalized CeO2 nanoparticles in a laboratory-scale activated sludge reactor. 
  • Transforming growth factor beta 1 dysregulation in a human oral carcinoma tumour progression model. 
  • Transgenic overexpression of the Ca2+-binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performance. 
  • Transient Hoogsteen base pairs in canonical duplex DNA. 
  • Transient kinetic approaches to enzyme mechanisms. 
  • Transient opening of fibronectin type III (FNIII) domains: the interaction of the third FNIII domain of FN with anastellin. 
  • Transmethylation reactions are required for initial morphologic and biochemical responses of human monocytes to chemoattractants. 
  • Transmethylation reactions regulate affinity and functional activity of chemotactic factor receptors on macrophages. 
  • Transmission coefficient calculation for proton transfer in triosephosphate isomerase based on the reaction path potential method. 
  • Transport interactions of cystine and dibasic amino acids in isolated rat renal tubules. 
  • Transport properties of the calcium ionophore ETH-129. 
  • Transport studies and enzyme assays in mice infected with human Giardia lamblia. 
  • Trimethoprim resistance in Haemophilus influenzae is due to altered dihydrofolate reductase(s). 
  • Trypsin digestion increases Na(+)-H+ exchange rates in native rabbit brush border membrane. 
  • Tryptic cleavage of rat liver sulfite oxidase. Isolation and characterization of molybdenum and heme domains. 
  • Tumor membrane lymphocyte stimulation assay in patients with renal cell carcinoma. 
  • Tumor physiology and charge dynamics of anticancer drugs: implications for camptothecin-based drug development. 
  • Tumor recognition and lytic competence of IL-2-activated lymphocytes: regulation of both antibody-independent and -dependent cellular cytotoxicity via P75 IL-2 receptor. 
  • Turnover rates of amino acid neurotransmitters in regions of rat cerebellum. 
  • Two distinct pathways for cAMP-mediated down-regulation of the beta 2-adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level. 
  • Two kinetically-distinct components of UDP-glucuronic acid transport in rat liver endoplasmic reticulum. 
  • Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. 
  • Two temporal phases of light adaptation in retinal rods. 
  • Two-dimensional tracking of ncd motility by back focal plane interferometry. 
  • Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea. 
  • Ultra-high expression of a thermally responsive recombinant fusion protein in E. coli. 
  • Ultra-rapid freezing of thin biological samples. 
  • Ultrafast excited-state dynamics of nanoscale near-infrared emissive polymersomes. 
  • Ultrastructure and function of the fractalkine mucin domain in CX(3)C chemokine domain presentation. 
  • Unconventional serotonergic excitation in Aplysia. 
  • Uncoupling of nucleotide hydrolysis and polymerization in the ParA protein superfamily disrupts DNA segregation dynamics. 
  • Underexpression of beta cell high Km glucose transporters in noninsulin-dependent diabetes. 
  • Understanding specificity and sensitivity of T-cell recognition. 
  • Understanding the Contributions of Conformational Changes, Thermodynamics, and Kinetics of RNA-Small Molecule Interactions. 
  • Understanding the Role of Aggregation in the Broad Absorption Bands of Eumelanin 
  • Underwater life support based on immobilized oxygen carriers. 
  • Unifying concept for the coupling between ion pumping and ATP hydrolysis or synthesis. 
  • Unique functional and structural properties of the LRRK2 protein ATP-binding pocket. 
  • Unique uncoupling of the frog erythrocyte adenylate cyclase system by manganese. Loss of hormone and guanine nucleotide-sensitive enzyme activities without loss of nucleotide-sensitive, high affinity agonist binding. 
  • Unsaturated fatty acid requirement in Escherichia coli: mechanism of palmitate-induced inhibition of growth of strain WN1. 
  • Unselected mutations in the human immunodeficiency virus type 1 genome are mostly nonsynonymous and often deleterious. 
  • Unveiling coherently driven hyperpolarization dynamics in signal amplification by reversible exchange. 
  • Uptake of proline by brushborder vesicles isolated from human kidney cortex. 
  • Uridine-based inhibitors as new leads for antibiotics targeting Escherichia coli LpxC. 
  • Use of SDS micelles to stabilize a ternary intermediate in the reaction of ferrioxamine B and 1,10-phenanthroline. 
  • Use of a multiple-enzyme/multiple-reagent assay system to quantify activity levels in samples containing mixtures of matrix metalloproteinases. 
  • Use of a specific probe for ovalbumin messenger RNA to quantitate estrogen-induced gene transcripts. 
  • Use of anti-idiotypic antibodies to establish that monoclonal antibody 7H11D6 binds to the alpha 2-macroglobulin receptor recognition site. 
  • Use of multiple radioligands to characterize adenosine receptors in human placenta. 
  • Use of okadaic acid to inhibit protein phosphatases in intact cells. 
  • Use of pH and kinetic isotope effects to establish chemistry as rate-limiting in oxidation of a peptide substrate by LSD1. 
  • Use of resampling techniques to estimate the variance of parameters in pharmacological assays when experimental protocols preclude independent replication: an example using Schild regressions. 
  • Use of short-term assays to evaluate the potential toxicity of two new biosoluble glasswool fibers. 
  • Use of the 125I-labeled protein gel overlay technique to study calmodulin-binding proteins. 
  • VSV transmembrane domain (TMD) peptide promotes PEG-mediated fusion of liposomes in a conformationally sensitive fashion. 
  • Vaccine-induced boosting of influenza virus-specific CD4 T cells in younger and aged humans. 
  • Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG. 
  • Vascular regulation of plasminogen activator inhibitor-1 activity. 
  • Vascular renin-angiotensin: a possible autocrine or paracrine system in control of vascular function. 
  • Ventromedial hypothalamic glucokinase is an important mediator of the counterregulatory response to insulin-induced hypoglycemia. 
  • Vip1 is a kinase and pyrophosphatase switch that regulates inositol diphosphate signaling. 
  • Visualizing reaction pathways in photoactive yellow protein from nanoseconds to seconds. 
  • Vitamins E and K induce aryl hydrocarbon hydroxylase activity in human cell cultures. 
  • Voltage-independent effects of extracellular K+ on the Na+ current and phase 0 of the action potential in isolated cardiac myocytes. 
  • Voltage-induced long-range coherent electron transfer through organic molecules. 
  • Voltammetric and mathematical evidence for dual transport mediation of serotonin clearance in vivo. 
  • Volume and osmotic properties of human neutrophils. 
  • Volume changes induced by osmotic stress in freshly isolated rat hippocampal neurons. 
  • Water permeability and mechanical strength of polyunsaturated lipid bilayers. 
  • Weight-bearing asymmetry in individuals post-hip fracture during the sit to stand task. 
  • What is biased efficacy? Defining the relationship between intrinsic efficacy and free energy coupling. 
  • Why Do Most Aromatics Fail to Support Hole Hopping in the Cytochrome c Peroxidase-Cytochrome c Complex? 
  • Why do Large Animals Never Actuate Their Jumps with Latch-Mediated Springs? Because They can Jump Higher Without Them. 
  • Wnt2 coordinates the commitment of mesoderm to hematopoietic, endothelial, and cardiac lineages in embryoid bodies. 
  • YbiV from Escherichia coli K12 is a HAD phosphatase. 
  • Zymogen proteolysis within the pancreatic acinar cell is associated with cellular injury. 
  • [125I]iodo-epidermal growth factor binding and mitotic responsiveness of porcine granulosa cells are modulated by differentiation and follicle-stimulating hormone. 
  • [3H]Dihydroergocryptine binding to alpha adrenergic receptors in canine aortic membranes. 
  • [3H]dihydroergocryptine binding in rat brain. 
  • [Benzodiazepine receptors of the mouse glioblastoma cell line: the anomalous effect of gamma-aminobutyric acid on diazepam binding]. 
  • [Identification and evaluation of properties of benzodiazepine receptors of glial and neuronal fractions of human cerebral cortex]. 
  • alpha-Adrenergic receptors in human adipocyte membranes: direct determination by [3H]yohimbine binding. 
  • alpha-Adrenergic receptors in rat parotid cells. I. Correlation of [3H]dihydroergocryptine binding and catecholamine-stimulated potassium efflux. 
  • alpha-Adrenergic receptors in rat parotid cells. II. Desensitization of receptor binding sites and potassium release. 
  • beta-Adrenergic receptor kinase. Activity of partial agonists for stimulation of adenylate cyclase correlates with ability to promote receptor phosphorylation. 
  • beta-Adrenergic receptor regulation by agonists and membrane depolarization in rat brain slices. 
  • beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. 
  • beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. 
  • beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics. 
  • cAMP stimulates transcription of the beta 2-adrenergic receptor gene in response to short-term agonist exposure. 
  • cAMP-associated inhibition of Na+-H+ exchanger in rabbit kidney brush-border membranes. 
  • cGMP suppresses GTPase activity of a portion of transducin equimolar to phosphodiesterase in frog rod outer segments. Light-induced cGMP decreases as a putative feedback mechanism of the photoresponse. 
  • cPLA2 regulates the expression of type I interferons and intracellular immunity to Chlamydia trachomatis. 
  • cis-dichlorodiammineplatinum (II) as a selective modifier of the oxidation-sensitive reactive-center methionine in alpha 1-antitrypsin. 
  • p-Amidino esters as irreversible inhibitors of factors IXa and Xa and thrombin. 
  • pH dependence of adenosine 5'-triphosphate synthesis and hydrolysis catalyzed by reconstituted chloroplast coupling factor. 
  • pH dependence of kinetics and steady-state block of cardiac sodium channels by lidocaine. 
  • pKa does not predict pH potentiation of sodium channel blockade by lidocaine and W6211 in guinea pig ventricular myocardium. 
  • pp60v-src kinase overexpression leads to cellular resistance to the antiproliferative effects of tumor necrosis factor. 
  • trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1. 
  • β-D-glucan surveillance with preemptive anidulafungin for invasive candidiasis in intensive care unit patients: a randomized pilot study. 
  • “Humidity-Dependent Dynamic Infrared Linear Dichroism of a Poly(Ester Urethane)” 
• 

  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Chitneni, Satish K., Associate Professor in Radiology, Radiology
  • Cianciolo, George James, Associate Professor Emeritus of Pathology, Pathology
  • Ciofani, Maria, Associate Professor of Integrative Immunobiology, Cell Biology
  • Cohen-Wolkowiez, Michael, Kiser-Arena Distinguished Professor, Pediatrics, Infectious Diseases
  • Craciunescu, Oana, Professor of Radiation Oncology, Radiation Oncology
  • Craig, Stephen L, William T. Miller Distinguished Professor of Chemistry, Nicholas Institute-Energy Initiative
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Ferrari, Guido, Professor in Surgery, Molecular Genetics and Microbiology
  • Ferreira, Paulo Alexandre, Associate Professor in Ophthalmology, Pathology
  • Henriquez, Craig S., Professor of Biomedical Engineering, Biomedical Engineering
  • Hirschey, Matthew, Associate Professor of Medicine, Cell Biology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Hsu-Kim, Heileen, Professor in the Department of Civil and Environmental Engineering, Civil and Environmental Engineering
  • Katz, David F., Nello L. Teer, Jr. Distinguished Professor of Biomedical Engineering, in the Edmund T. Pratt, Jr. School of Engineering, Biomedical Engineering
  • Laskowitz, Daniel Todd, Professor of Neurology, Duke Science & Society
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Oas, Terrence Gilbert, Professor of Biochemistry, Biochemistry
  • Patz Jr., Edward F., James and Alice Chen Distinguished Professor of Radiology, Pathology
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology
  • Sullivan, Daniel Carl, Professor Emeritus of Radiology, Radiology
  • Sunday, Mary Elizabeth Anne, Professor of Pathology, Cell Biology
  • Vengosh, Avner, Nicholas Distinguished Professor of Environmental Quality, Nicholas Institute-Energy Initiative
  • Zennadi, Rahima, Associate Professor in Medicine, Pathology