Peptidyl-Dipeptidase A

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  Subject Areas on Research

  • A Fluorometric Method of Measuring Carboxypeptidase Activities for Angiotensin II and Apelin-13. 
  • A Meta-analysis of the Relationship Between Renin-Angiotensin-Aldosterone System Inhibitors and COVID-19. 
  • A genome-wide association study identifies new loci for ACE activity: potential implications for response to ACE inhibitor. 
  • ACE and ACE2 activity in diabetic mice. 
  • Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice. 
  • Angiotensin AT1 receptor inhibition. Effects on hypertrophic remodeling and ACE expression in rats with pressure-overload hypertrophy due to ascending aortic stenosis. 
  • Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway. 
  • Angiotensin converting enzyme 2 and the kidney. 
  • Angiotensin converting enzyme and genetic hypertension: cloning of rat cDNAs and characterization of the enzyme. 
  • Angiotensin converting enzyme in renal ontogeny: hypothesis for multiple roles. 
  • Angiotensin converting enzyme inhibitors and Alzheimer disease in the presence of the apolipoprotein E4 allele. 
  • Angiotensin-converting enzyme 2 (ACE2) levels in relation to risk factors for COVID-19 in two large cohorts of patients with atrial fibrillation. 
  • Angiotensin-converting enzyme 2 gene targeting studies in mice: mixed messages. 
  • Angiotensin-converting enzyme gene and retinal arteriolar narrowing: the Funagata Study. 
  • Angiotensin-converting enzyme gene insertion/deletion polymorphism and cardiovascular disease: identifying the guideposts for navigating the genetics landscape. 
  • Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the AASK trial. 
  • Angiotensin-converting enzyme genotype predicts cardiac and autonomic responses to prolonged exercise. 
  • Antisense oligodeoxynucleotide inhibition of vascular angiotensin-converting enzyme expression attenuates neointimal formation: evidence for tissue angiotensin-converting enzyme function. 
  • Association of angiotensinogen gene T235 variant with increased risk of coronary heart disease. 
  • Cardiovascular molecular mechanisms of disease with COVID-19. 
  • Chronic N(G)-nitro-L-arginine methyl ester-induced hypertension : novel molecular adaptation to systolic load in absence of hypertrophy. 
  • Classical Renin-Angiotensin system in kidney physiology. 
  • Cleavage of the SARS coronavirus spike glycoprotein by airway proteases enhances virus entry into human bronchial epithelial cells in vitro. 
  • Continuing versus suspending angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: Impact on adverse outcomes in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)--The BRACE CORONA Trial. 
  • Controversies of renin-angiotensin system inhibition during the COVID-19 pandemic. 
  • Developmental renin expression in mice with a defective renin-angiotensin system. 
  • Differential effects of captopril and enalapril on tissue renin-angiotensin systems in experimental heart failure. 
  • Distribution and functional significance of cardiac angiotensin converting enzyme in hypertrophied rat hearts. 
  • Effect of captopril on the release of the components of the renin-angiotensin system into plasma and lymph. 
  • Efficient in vivo gene transfer into the heart in the rat myocardial infarction model using the HVJ (Hemagglutinating Virus of Japan)--liposome method. 
  • Emergence of SARS-CoV-2 through recombination and strong purifying selection. 
  • Emerging Viral Infections and the Potential Impact on Hypertension, Cardiovascular Disease, and Kidney Disease. 
  • Evidence for direct local effect of angiotensin in vascular hypertrophy. In vivo gene transfer of angiotensin converting enzyme. 
  • Feedback regulation of angiotensin converting enzyme activity and mRNA levels by angiotensin II. 
  • Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6. 
  • Gene expression of the renin-angiotensin system in human tissues. Quantitative analysis by the polymerase chain reaction. 
  • Gene targeting in physiological investigations: studies of the renin-angiotensin system. 
  • Gene-targeting studies of the renin-angiotensin system: mechanisms of hypertension and cardiovascular disease. 
  • Genetic manipulation of the renin-angiotensin system. 
  • Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. 
  • Hydrolysis by somatic angiotensin-I converting enzyme of basic dipeptides from a cholecystokinin/gastrin and a LH-RH peptide extended at the C-terminus with gly-Arg/Lys-arg, but not from diarginyl insulin. 
  • Immortalized rat proximal tubule cell lines expressing components of the renin-angiotensin system. 
  • Immunologic Effects of the Renin-Angiotensin System. 
  • Impact of genetic polymorphisms on heart failure prognosis. 
  • In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19. 
  • Increased accumulation of tissue ACE in human atherosclerotic coronary artery disease. 
  • Increased rat cardiac angiotensin converting enzyme activity and mRNA expression in pressure overload left ventricular hypertrophy. Effects on coronary resistance, contractility, and relaxation. 
  • Induction of angiotensin converting enzyme in the neointima after vascular injury. Possible role in restenosis. 
  • Is Hypertension a Real Risk Factor for Poor Prognosis in the COVID-19 Pandemic? 
  • Kallikrein-related mRNAs of the rat submaxillary gland: nucleotide sequences of four distinct types including tonin. 
  • Length Polymorphisms in the Angiotensin I-Converting Enzyme Gene and the Serotonin-Transporter-Linked Polymorphic Region Constitute a Risk Haplotype for Depression in Patients with Coronary Artery Disease. 
  • Local expression and pathophysiological role of renin-angiotensin in the blood vessels and heart. 
  • Mechanism of action of angiotensin-converting enzyme (ACE) inhibitors in hypertension and heart failure. Role of plasma versus tissue ACE. 
  • Mechanism of protective effects of ACE inhibition on coronary artery disease. 
  • Molecular biology and pathophysiology of the intrarenal renin-angiotensin system. 
  • Molecular biology of angiotensin receptors: target for drug research? 
  • Multiple pathways of angiotensin production in the blood vessel wall: evidence, possibilities and hypotheses. 
  • New mass spectrometric assay for angiotensin-converting enzyme 2 activity. 
  • Nodular sarcoidosis of the liver and spleen: analysis of 32 cases. 
  • Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia. 
  • Novel ACE2-Fc chimeric fusion provides long-lasting hypertension control and organ protection in mouse models of systemic renin angiotensin system activation. 
  • Novel and effective gene transfer technique for study of vascular renin angiotensin system. 
  • Novel in vitro gene transfer method for study of local modulators in vascular smooth muscle cells. 
  • Novel peptide inhibitors of angiotensin-converting enzyme 2. 
  • Parallel effects of genetic variation in ACE activity in baboons and humans. 
  • Pathophysiologic and therapeutic importance of tissue ACE: a consensus report. 
  • Polymorphism of angiotensin converting enzyme gene is associated with circulating levels of plasminogen activator inhibitor-1. 
  • Polymorphisms in the ACE and ADRB2 genes and risks of aging-associated phenotypes: the case of myocardial infarction. 
  • Recent advances involving the renin-angiotensin system. 
  • Relations between deletion polymorphism of the angiotensin-converting enzyme gene and insulin resistance, glucose intolerance, hyperinsulinemia, and dyslipidemia. 
  • Remodeling and reparation of the cardiovascular system. 
  • Renal endosomes contain angiotensin peptides, converting enzyme, and AT(1A) receptors. 
  • Renin-angiotensin-aldosterone genotype influences ventricular remodeling in infants with single ventricle. 
  • SARS CoV subunit vaccine: antibody-mediated neutralisation and enhancement. 
  • SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues. 
  • SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract. 
  • Serum angiotensin converting enzyme activity in evaluation of patients with liver disease. 
  • Severe Acute Respiratory Syndrome Coronavirus 2, COVID-19, and the Renin-Angiotensin System: Pressing Needs and Best Research Practices. 
  • Soluble ACE2 Is Filtered into the Urine. 
  • Sound Science before Quick Judgement Regarding RAS Blockade in COVID-19. 
  • Targeting genes in the renin-angiotensin system. 
  • The relevance of tissue angiotensin-converting enzyme: manifestations in mechanistic and endpoint data. 
  • Theodore Cooper Lecture: Tissue angiotensin and pathobiology of vascular disease: a unifying hypothesis. 
  • Tissue angiotensin system in cardiovascular medicine. A paradigm shift? 
  • Tissue renin-angiotensin system in myocardial hypertrophy and failure. 
  • Tissue-specific activation of cardiac angiotensin converting enzyme in experimental heart failure. 
  • Vascular renin-angiotensin system and vascular protection. 
  • cAMP-response element modulator tau is a positive regulator of testis angiotensin converting enzyme transcription. 
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  Keywords of People

  • Alberts, Susan C., Robert F. Durden Distinguished Professor of Biology, Duke Science & Society