Lac Operon

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  Subject Areas on Research

  • A 1.3 kb promoter fragment confers spatial and temporal expression of utrophin A mRNA in mouse skeletal muscle fibers. 
  • A specific 31-nucleotide domain of U1 RNA directly interacts with the 70K small nuclear ribonucleoprotein component. 
  • AMH induces mesonephric cell migration in XX gonads. 
  • Accelerated deamination of cytosine residues in UV-induced cyclobutane pyrimidine dimers leads to CC-->TT transitions. 
  • Allocation of epiblast cells to germ layer derivatives during mouse gastrulation as studied with a retroviral vector. 
  • Characterization of a gene trap insertion into a novel gene, cordon-bleu, expressed in axial structures of the gastrulating mouse embryo. 
  • Correlation of doxorubicin footprints with deletion endpoints in lacO of E. coli. 
  • Crystal structure of the lactose operon repressor and its complexes with DNA and inducer. 
  • DNA sequence specificity of doxorubicin-induced mutational damage in uvrB- Escherichia coli. 
  • Dhh1 regulates the G1/S-checkpoint following DNA damage or BRCA1 expression in yeast. 
  • Effect of isopropyl-beta-D-thiogalactopyranosid induction of the lac operon on the specificity of spontaneous and doxorubicin-induced mutations in Escherichia coli. 
  • Ependymal/subependymal zone cells of postnatal and adult songbird brain generate both neurons and nonneuronal siblings in vitro and in vivo. 
  • Ex vivo adenovirus-mediated gene transfer to the adult rat heart. 
  • Expression of the human poliovirus receptor/CD155 gene during development of the central nervous system: implications for the pathogenesis of poliomyelitis. 
  • Focused ultrasound (HIFU) induces localized enhancement of reporter gene expression in rabbit carotid artery. 
  • Gene transfer to the thymus. A means of abrogating the immune response to recombinant adenovirus. 
  • Generation of a loxP flanked bmp4loxP-lacZ allele marked by conditional lacZ expression. 
  • Ghrelin enhances olfactory sensitivity and exploratory sniffing in rodents and humans. 
  • Graft-extrinsic cells predominate in vein graft arterialization. 
  • Increased expression of utrophin in a slow vs. a fast muscle involves posttranscriptional events. 
  • Local production of TGF beta1 inhibits cerebral edema, enhances TNF-alpha induced apoptosis and improves survival in a murine glioma model. 
  • Local secretion of IL-12 augments the therapeutic impact of dendritic cell-tumor cell fusion vaccination. 
  • Long-term mutagenicity studies with chloroform and dimethylnitrosamine in female lacI transgenic B6C3F1 mice. 
  • Minimal phenotype of mice homozygous for a null mutation in the forkhead/winged helix gene, Mf2. 
  • Mutagenicity of ochratoxin A and its hydroquinone metabolite in the SupF gene of the mutation reporter plasmid Ps189. 
  • Mutational fingerprints of aging. 
  • Myocardial injury-induced fibroblast proliferation facilitates retroviral-mediated gene transfer to the rat heart in vivo. 
  • Notch/Delta expression in the developing mouse lung. 
  • Potential for germ line transmission after intramyocardial gene delivery by adeno-associated virus. 
  • Recruitment of marrow-derived endothelial cells to experimental choroidal neovascularization by local expression of vascular endothelial growth factor. 
  • Regulation of flt-1 expression during mouse embryogenesis suggests a role in the establishment of vascular endothelium. 
  • Retargeting mobile group II introns to repair mutant genes. 
  • Ribozyme-mediated repair of defective mRNA by targeted, trans-splicing. 
  • Synthesis and evaluation of 18F- and 11C-labeled phenyl-galactopyranosides as potential probes for in vivo visualization of LacZ gene expression using positron emission tomography. 
  • Tagging ribozyme reaction sites to follow trans-splicing in mammalian cells. 
  • Tamoxifen-inducible gene deletion reveals a distinct cell type associated with trabecular bone, and direct regulation of PTHrP expression and chondrocyte morphology by Ihh in growth region cartilage. 
  • Targeted gene transfer to Schlemm's canal by retroperfusion. 
  • Therapeutic vaccine generated by electrofusion of dendritic cells and tumour cells. 
  • Transduction of renal cells in vitro and in vivo by adeno-associated virus gene therapy vectors. 
  • Transgenic mice expressing a constitutively active retinoic acid receptor in the lens exhibit ocular defects. 
  • Tumor-dendritic cell fusion as a basis for cancer immunotherapy. 
  • Visualizing an olfactory sensory map. 
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  Keywords of People

  • Chitneni, Satish K., Associate Professor in Radiology, Radiology