L-Lactate Dehydrogenase

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  Subject Areas on Research

  • 2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Adult Dermatomyositis and Polymyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative. 
  • 2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Juvenile Dermatomyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative. 
  • A novel link between G6PD deficiency and hemolysis in patients with continuous-flow left ventricular assist devices. 
  • ATM deficiency promotes progression of CRPC by enhancing Warburg effect. 
  • Abnormal cardiac enzyme responses after strenuous exercise: alternative diagnostic aids. 
  • Absence of direct antioxidant effects from volatile anesthetics in primary mixed neuronal-glial cultures. 
  • Accuracy of total serum enzymes and myocardial specific isoenzymes--a comparative study. 
  • Acetaminophen toxicity in cultured trout liver cells. I. Morphological alterations and effects on cytochrome P450 1A1. 
  • Acute, subacute, and residual effects of polychlorinated biphenyl (pcb) in rats. II. Pathology and electron microscopy of liver and serum enzyme study. 
  • Adaptive Activation of a Stress Response Pathway Improves Learning and Memory Through Gs and β-Arrestin-1-Regulated Lactate Metabolism. 
  • Allopregnanolone attenuates N-methyl-D-aspartate-induced excitotoxicity and apoptosis in the human NT2 cell line in culture. 
  • Alpha-tocopheryl succinate protects hepatocytes from chemical-induced toxicity under physiological calcium conditions. 
  • An antibody-free dual-biomarker rapid enrichment workflow (AnDREW) improves the sensitivity of malaria rapid diagnostic tests. 
  • Analysis of injury in complex organ preservation. 
  • Anesthetic effects on the glycerol model of rhabdomyolysis-induced acute renal failure in rats. 
  • Angiotensin protects cortical neurons from hypoxic-induced apoptosis via the angiotensin type 2 receptor. 
  • Anoxia induces phospholipase A2 activation in rabbit renal proximal tubules. 
  • Anti-tumor necrosis factor-alpha therapy augments dipeptidyl peptidase IV activity and decreases autoantibodies to GRP78/BIP and phosphoglucose isomerase in patients with rheumatoid arthritis. 
  • Antiinflammatory effects of neoplasms. 
  • Antioxidant defense mechanisms in cultured pleural mesothelial cells. 
  • Apolipoprotein E protects against oxidative stress in mixed neuronal-glial cell cultures by reducing glutamate toxicity. 
  • Apoptosis occurs in isolated and banked primary mouse hepatocytes. 
  • Assessment of low-flow sevoflurane and isoflurane effects on renal function using sensitive markers of tubular toxicity. 
  • Association between cytotoxic and invasive Pseudomonas aeruginosa and clinical outcomes in bacterial keratitis. 
  • Atypical chronic myeloid leukemia is clinically distinct from unclassifiable myelodysplastic/myeloproliferative neoplasms. 
  • Biochemical and structural changes in cultured heart cells induced by metabolic inhibition. 
  • Biological effects of desert dust in respiratory epithelial cells and a murine model. 
  • Biomarkers in the management and treatment of men with metastatic castration-resistant prostate cancer. 
  • Branched-chain amino acid supplementation and indicators of muscle damage after endurance exercise. 
  • Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery. 
  • Cardiac fatigue after prolonged exercise. 
  • Cellular source of serum lactate dehydrogenase elevation in patients with thrombotic thrombocytopenic purpura. 
  • Centronuclear myopathy: histochemistry and electron microscopy. Report of two cases. 
  • Characterization of Plasmodium Lactate Dehydrogenase and Histidine-Rich Protein 2 Clearance Patterns via Rapid On-Bead Detection from a Single Dried Blood Spot. 
  • Cisplatin and 5-fluorouracil infusion for metastatic colorectal carcinoma. Differences in survival in two patient groups with similar response rates. 
  • Citrate and vitamin E blunt the shock wave-induced free radical surge in an in vitro cell culture model. 
  • Comparison of real-time PCR and microscopy for malaria parasite detection in Malawian pregnant women. 
  • Connect MM Registry: The Importance of Establishing Baseline Disease Characteristics. 
  • Correlating nanoscale titania structure with toxicity: a cytotoxicity and inflammatory response study with human dermal fibroblasts and human lung epithelial cells. 
  • Corticosteroids improve survival of children with AIDS and Pneumocystis carinii pneumonia. 
  • Creatine kinase overexpression improves ATP kinetics and contractile function in postischemic myocardium. 
  • Culture kinetics of glycolytic enzyme induction, glucose utilization, and thymidine incorporation of extended-exposure phytohemagglutinin-stimulated human lymphocytes. 
  • Cutaneous γδ T-cell lymphomas: a spectrum of presentations with overlap with other cytotoxic lymphomas. 
  • Cyclic mechanical stress and trabecular meshwork cell contractility. 
  • Cytotoxicity of S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl) vinyl ether (Compound A) in a human proximal tubular cell line. 
  • Detection of necrosis by release of lactate dehydrogenase activity. 
  • Detection of pyroptosis by measuring released lactate dehydrogenase activity. 
  • Early intervention for lactate dehydrogenase elevation improves clinical outcomes in patients with the HeartMate II left ventricular assist device: Insights from the PREVENT study. 
  • Effect of halothane in cortical cell cultures exposed to N-methyl-D-aspartate. 
  • Effect of lipophilicity of Mn (III) ortho N-alkylpyridyl- and diortho N, N'-diethylimidazolylporphyrins in two in-vitro models of oxygen and glucose deprivation-induced neuronal death. 
  • Effects of TNF-alpha on expression of ICAM-1 in human airway epithelial cells in vitro. Signaling pathways controlling surface and gene expression. 
  • Effects of repetitive motion on human fibroblasts. 
  • Electroconvulsive therapy does not change serum CK, LD, or LD isoenzymes. 
  • Extrinsic coagulation blockade attenuates lung injury and proinflammatory cytokine release after intratracheal lipopolysaccharide. 
  • Fleeting activation of ionotropic glutamate receptors sensitizes cortical neurons to complement attack. 
  • Fundamental metabolic differences between hepatocytes and islet beta-cells revealed by glucokinase overexpression. 
  • GluR3 autoantibodies destroy neural cells in a complement-dependent manner modulated by complement regulatory proteins. 
  • Glutathione depletion in epithelial lining fluid of lung allograft patients. 
  • Glycogen debranching enzyme deficiency: long-term study of serum enzyme activities and clinical features. 
  • Hemodynamic and metabolic variables predict porcine ex vivo liver function. 
  • Hepatotoxic effects of CCl4 on English sole (Parophrys vetulus): possible indicators of liver dysfunction. 
  • Hypoxic cell death is reduced by pH buffering in a model of engineered heart tissue. 
  • Immunomagnetic capture and colorimetric detection of malarial biomarker Plasmodium falciparum lactate dehydrogenase. 
  • In vitro determinants of asbestos fiber toxicity: effect on the relative toxicity of Libby amphibole in primary human airway epithelial cells. 
  • Insignificant blood damage in calves with a total artificial heart up to six months. 
  • Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) analysis of pump thrombosis in the HeartMate II left ventricular assist device. 
  • Intravillous eicosanoid compartmentalization and regulation of placental blood flow. 
  • LDH isoenzymes and myocardial infarction in patients undergoing coronary bypass surgery: an excellent correlation. 
  • Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS. 
  • Late appearance of skin rash and abnormal serum enzymes in Rocky Mountain spotted fever. A case report. 
  • Liposome-mediated augmentation of superoxide dismutase in endothelial cells prevents oxygen injury. 
  • Long-term survival and biomarker correlates of tasquinimod efficacy in a multicenter randomized study of men with minimally symptomatic metastatic castration-resistant prostate cancer. 
  • Mediators, initiating the inflammatory response, released in organ culture by full-thickness human skin explants exposed to the irritant, sulfur mustard. 
  • Metabolic variation among rat lumbosacral alpha-motoneurons. 
  • Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes. 
  • NMDA-induced apoptosis in mixed neuronal/glial cortical cell cultures: the effects of isoflurane and dizocilpine. 
  • Nano-C60 cytotoxicity is due to lipid peroxidation. 
  • Neuroprotective effects of NMDA receptor glycine recognition site antagonism: dependence on glycine concentration. 
  • Neuroprotective effects of group III mGluR in traumatic neuronal injury. 
  • New in vitro model of traumatic neuronal injury: evaluation of secondary injury and glutamate receptor-mediated neurotoxicity. 
  • Normal serum activities of some diagnostic enzymes in dromedary camel in Sudan. 
  • Oxidant-mediated Akt activation in human RPE cells. 
  • Patterns of platelet response in idiopathic TTP/HUS: frequency of declining platelet counts with plasma exchange and the recognition and significance of a pseudo refractory state. 
  • Phase 1 dose escalation trial of the safety and pharmacokinetics of cabozantinib concurrent with temozolomide and radiotherapy or temozolomide after radiotherapy in newly diagnosed patients with high-grade gliomas. 
  • Phylogenetic analysis of vertebrate lactate dehydrogenase (LDH) multigene families. 
  • Platelet adhesion on a bioresorbable poly(propylene fumarate-co-ethylene glycol) copolymer. 
  • Pleural effects of indium phosphide in B6C3F1 mice: nonfibrous particulate induced pleural fibrosis. 
  • Primary CNS lymphoma in HIV positive and negative patients: comparison of clinical characteristics, outcome and prognostic factors. 
  • Prognostic features and treatment outcome in locoregionally advanced nasopharyngeal carcinoma following concurrent chemotherapy and radiotherapy. 
  • Prognostic impact of the neutrophil-to-lymphocyte ratio in men with metastatic castration-resistant prostate cancer. 
  • Prognostic indicators in hormone refractory prostate cancer. 
  • Prognostic variables in patients with hepatic metastases from colorectal cancer. Importance of medical assessment of liver involvement. 
  • Protective effects of ischemic preconditioning on the cold-preserved liver are tyrosine kinase dependent. 
  • Protein kinase C inhibition abrogates hepatic ischemic preconditioning responses. 
  • Pulmonary hypertension and nitric oxide depletion in sickle cell disease. 
  • Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step. 
  • RIPK1-RIPK3-MLKL-Associated Necroptosis Drives Leishmania infantum Killing in Neutrophils. 
  • Recent advances in de novo CD5+ diffuse large B cell lymphoma. 
  • Recognition of early mortality in multiple myeloma by a prediction matrix. 
  • Regulation of tumor necrosis factor cytotoxicity by calcineurin. 
  • Relapse of thrombotic thrombocytopenic purpura: is it a continuum of disease? 
  • Reply to M A Khattak et al. 
  • Resistance of pancreatic carcinoma cells is reversed by coculturing NK-like T cells with dendritic cells pulsed with tumor-derived RNA and CA 19-9. 
  • Role of aquaporin-1 in trabecular meshwork cell homeostasis during mechanical strain. 
  • Serum enzyme alterations after extensive surgical procedures. 
  • Serum enzyme alterations in hypothyroidism before and after treatment. 
  • Serum hepatic enzyme and bilirubin elevations during parenteral nutrition. 
  • Serum lactate dehydrogenase predicts for overall survival benefit in patients with metastatic renal cell carcinoma treated with inhibition of mammalian target of rapamycin. 
  • Similar but not the same: normobaric and hyperbaric pulmonary oxygen toxicity, the role of nitric oxide. 
  • Simultaneous capture and sequential detection of two malarial biomarkers on magnetic microparticles. 
  • Spectrum and subcellular determinants of fluorinated anesthetic-mediated proximal tubular injury. 
  • Structure, function, and phylogeny of the mating locus in the Rhizopus oryzae complex. 
  • Survival, disease progression and prognostic factors in elderly patients with mycosis fungoides and Sézary syndrome: a retrospective analysis of 174 patients. 
  • Testicular cancer. Clinical practice guidelines in oncology. 
  • The effect of dexamethasone on the generation of plasma DNA from dead and dying cells. 
  • The high-production volume fungicide pyraclostrobin induces triglyceride accumulation associated with mitochondrial dysfunction, and promotes adipocyte differentiation independent of PPARγ activation, in 3T3-L1 cells. 
  • The indispensability of heme oxygenase-1 in protecting against acute heme protein-induced toxicity in vivo. 
  • The properties of microparticles from RAW 264.7 macrophage cells undergoing in vitro activation or apoptosis. 
  • The relationship between enzymatic and histologic estimates of the extent of myocardial infarction in conscious dogs with permanent coronary occlusion. 
  • The release of DNA into the plasma of mice following hepatic cell death by apoptosis and necrosis. 
  • The spontaneously hypertensive rat: an experimental model of sulfur dioxide-induced airways disease. 
  • Thermodynamic analysis of a molecular chaperone binding to unfolded protein substrates. 
  • Thrombogenicity markers for early diagnosis and prognosis in COVID-19: a change from the current paradigm? 
  • Tissue engineering of functional cardiac muscle: molecular, structural, and electrophysiological studies. 
  • Toxic effects of catecholamines on skin. 
  • Transient abnormalities in serum bilirubin and lactate dehydrogenase levels following red blood cell transfusions in adults. 
  • Unexpected abrupt increase in left ventricular assist device thrombosis. 
  • United States Thrombotic Thrombocytopenic Purpura Apheresis Study Group (US TTP ASG): multicenter survey and retrospective analysis of current efficacy of therapeutic plasma exchange. 
  • Urine and serum lactic dehydrogenase, lactic dehydrogenase isoenzymes, and alkaline phosphatase in the nephrotic syndrome. 
  • [Stimulating effect of schizophrenic patients' plasma on the cellular incorportation of tryptophan in vitro]. 
  • mGluR modulation of post-traumatic neuronal death: role of NMDA receptors. 
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  Keywords of People

  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Preminger, Glenn Michael, James F. Glenn, M.D. Distinguished Professor of Urology, Surgery, Urology