Lactates

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  Subject Areas on Research

  • A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion. 
  • A yeast cyclophilin gene essential for lactate metabolism at high temperature. 
  • Activated α2-macroglobulin binding to human prostate cancer cells triggers insulin-like responses. 
  • Acute stroke: evaluation with serial proton MR spectroscopic imaging. 
  • Allostery in Callinectes sapidus hemocyanin: cooperative oxygen binding and interactions with L-lactate, calcium, and protons. 
  • Amelioration of proximal renal tubular dysfunction in type I glycogen storage disease with dietary therapy. 
  • Analysis of injury in complex organ preservation. 
  • Analysis of volatile free fatty acids in human urine by capillary column gas chromatography/mass spectrometry. 
  • Anxiety and cerebral blood flow. 
  • Beta 1-selective and non-selective beta-adrenoceptor blockade, anaerobic threshold and respiratory gas exchange during exercise. 
  • Biomaterials community examines biosensor biocompatibility. 
  • Blood lactate: biochemistry, laboratory methods, and clinical interpretation. 
  • Carbohydrate restriction and lactate transporter inhibition in a mouse xenograft model of human prostate cancer. 
  • Cardiac and muscle fatigue due to relative functional overload induced by excessive stimulation, hypersensitive excitation-contraction coupling, or diminished performance capacity correlates with sarcoplasmic reticulum failure. 
  • Cardiac function after restoration of flow in acute coronary occlusion. 
  • Cerebral blood flow changes during sodium-lactate-induced panic attacks. 
  • Clinical determinants and prognostic significance of hypocapnia in acute heart failure. 
  • Computational design of a biologically active enzyme. 
  • Cornstarch therapy in type I glycogen-storage disease. 
  • Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2',3'-dideoxycytidine. 
  • Determination of L-lactate binding stoichiometry and differences in allosteric interactions of structurally distinct homohexamers from Panulirus interruptus hemocyanin. 
  • Dialysate and blood flow dependence of diffusive solute clearance during CVVHD. 
  • Differential metabolic effects of adenovirus-mediated glucokinase and hexokinase I overexpression in rat primary hepatocytes. 
  • Differentiation of hemodynamic, humoral and metabolic responses to beta 1- and beta 2-adrenergic stimulation in man using atenolol and propranolol. 
  • Doxorubicin-loaded protease-activated near-infrared fluorescent polymeric nanoparticles for imaging and therapy of cancer. 
  • ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer. 
  • Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial. 
  • Effect of cystine loading on substrate oxidation by rat renal tubules. 
  • Effects of beta 1-selective and nonselective beta-adrenoceptor blockade during exercise conditioning in healthy adults. 
  • Effects of cysteamine therapy in nephropathic cystinosis. 
  • Effects of in vivo and in vitro production of lactic acid on ionized, protein-bound, and complex-bound calcium in blood. 
  • Effects of modulation of glycerol kinase expression on lipid and carbohydrate metabolism in human muscle cells. 
  • Effects of muscle contraction on cytochrome a,a3 redox state. 
  • Effects of storage temperature and time before centrifugation on ionized calcium in blood collected in plain vacutainer tubes and silicone-separator (SST) tubes. 
  • Effects of therapy on the 1H NMR spectrum of a human glioma line. 
  • Efficient hepatic glycogen synthesis in refeeding rats requires continued carbon flow through the gluconeogenic pathway. 
  • Evaluation of poly(L-lactic acid) as a material for intravascular polymeric stents. 
  • From dietary glucose to liver glycogen: the full circle round. 
  • Glucose 6-phosphate produced by glucokinase, but not hexokinase I, promotes the activation of hepatic glycogen synthase. 
  • Glucose utilization by edematous rat lungs. 
  • Heart rate and metabolic response to competitive squash in veteran players: identification of risk factors for sudden cardiac death. 
  • Hemodynamic and metabolic responses to exercise after alpha 1-, beta 1-, and nonselective beta-adrenoceptor blockade in man. 
  • Increased rate of peripheral nerve regeneration using bioresorbable nerve guides and a laminin-containing gel. 
  • Insulin therapy for ketolactic acidosis complicating malignancy. 
  • Interpretation of blood lactate measurements in paediatric open-heart surgery and in extracorporeal membrane oxygenation. 
  • Isolated perfused lung--substrate utilization. 
  • Lactate measured in diluted and undiluted whole blood and plasma: comparison of methods and effect of hematocrit. 
  • Lactate, oxygen uptake, and cycling performance in triathletes. 
  • Late-onset Mcardle's disease with unusual electromyographic findings. 
  • Metabolic and ventilatory responses to steady state exercise relative to lactate thresholds. 
  • Myocardial energetics and blood flow in acute rapid ventricular pacing. 
  • Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease. 
  • Noninvasive differentiation of tumors with use of localized H-1 spectroscopy in vivo: initial experience in patients with cerebral tumors. 
  • Peripheral nerve regeneration with entubulation repair: comparison of biodegradeable nerve guides versus polyethylene tubes and the effects of a laminin-containing gel. 
  • Physiological responses to exercise at 47 and 66 ATA. 
  • Physiology and regulation. Ionized calcium, magnesium and lactate measurements in critical care settings. 
  • Polarographic cerebral oxygen availability, fluorocarbon blood levels and efficacy of oxygen transport by emulsions. 
  • Prolongation of normoglycemia in patients with type I glycogen storage disease. 
  • Proton magnetic resonance spectroscopic imaging in childhood ataxia with diffuse central nervous system hypomyelination. 
  • Quantitative proton spectroscopy and histology of a canine brain tumor model. 
  • Relationship between serum lactate and ionized calcium in open-heart surgery. 
  • Reversing the Warburg effect as a treatment for glioblastoma. 
  • Separation and quantitation of serum constituents associated with calcium by gel filtration. 
  • Skeletal muscle pH assessed by biochemical and 31P-MRS methods during exercise and recovery in men. 
  • Studies on the mechanism by which exogenous glucose is converted into liver glycogen in the rat. A direct or an indirect pathway? 
  • Tezosentan normalizes hepatomesenteric perfusion in a porcine model of cardiac tamponade. 
  • The effect of flunarizine on erythrocyte suspension viscosity under conditions of extreme hypoxia, low pH, and lactate treatment. 
  • The effect of irrigation solution at different temperatures on articular cartilage metabolism. 
  • The effects of high intensity exercise on muscle and plasma levels of alpha-ketoisocaproic acid. 
  • The ischemic exercise test in normal adults and in patients with weakness and cramps. 
  • The nature of fluorocarbon enhanced cerebral oxygen transport. 
  • Theophylline produces an adverse effect on myocardial lactate metabolism at a therapeutic serum concentration: an effect blocked by verapamil. 
  • Ventilatory control studied with circulatory occlusion during exercise recovery. 
  • Visual activation in alpha-chloralose-anaesthetized cats does not cause lactate accumulation in the visual cortex as detected by [1H]NMR difference spectroscopy. 
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  Keywords of People

  • Charles, Hal Cecil, Adjunct Associate Professor in the Department of Radiology, Radiology