Lasers

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  Subject Areas on Research

  • 6450 nm wavelength tissue ablation using a nanosecond laser based on difference frequency mixing and stimulated Raman scattering. 
  • A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)-Cell Interaction and the Resultant Bioeffects at the Single-cell Level. 
  • A comparative study of monoclonal gammopathies and immunoglobulin levels in Japanese and United States elderly. 
  • A comparative study of retinal effects from continuous wave and femtosecond mode-locked lasers. 
  • A hyperspectral imaging system for in vivo optical diagnostics. Hyperspectral imaging basic principles, instrumental systems, and applications of biomedical interest. 
  • A method for measuring the presampled MTF of digital radiographic systems using an edge test device. 
  • A miniature biochip system for detection of aerosolized Bacillus globigii spores. 
  • A positioning QA procedure for 2D/2D (kV/MV) and 3D/3D (CT/CBCT) image matching for radiotherapy patient setup. 
  • A practical three-dimensional dosimetry system for radiation therapy. 
  • APOE Isoforms Control Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration. 
  • Advanced magnetic resonance imaging of cerebral cavernous malformations: part II. Imaging of lesions in murine models. 
  • Agreement between stereophotographic and confocal scanning laser ophthalmoscopy measurements of cup/disc ratio: effect on a predictive model for glaucoma development. 
  • Altered ligand rebinding kinetics due to distal-side effects in hemoglobin chico (Lysbeta66(E10) --> thr). 
  • An AOTF-based dual-modality hyperspectral imaging system (DMHSI) capable of simultaneous fluorescence and reflectance imaging. 
  • Antibody-conjugated gold-gold sulfide nanoparticles as multifunctional agents for imaging and therapy of breast cancer. 
  • Antimicrobial and bacteria-releasing multifunctional surfaces: oligo (p-phenylene-ethynylene)/poly (N-isopropylacrylamide) films deposited by RIR-MAPLE. 
  • Antimicrobial oligo(p-phenylene-ethynylene) film deposited by resonant infrared matrix-assisted pulsed laser evaporation. 
  • Application of an antibody biochip for p53 detection and cancer diagnosis. 
  • Application of oligonucleotide microarrays to assess the biological effects of neoadjuvant imatinib mesylate treatment for localized prostate cancer. 
  • Application of rapid scanning retinal thickness analysis in retinal diseases. 
  • Applications of free-electron lasers in the biological and material sciences. 
  • Argon laser retinal lesions evaluated in vivo by optical coherence tomography. 
  • Argon laser treatment of central serous chorioretinopathy. 
  • Association of age, stature, and education with ocular dimensions in an older white population. 
  • Behavior of the copper band of cytochrome c oxidase in rat brain during FC-43-for-blood substitution. 
  • Biological magnetic resonance imaging using laser-polarized 129Xe. 
  • Blood perfusion measurements in human tumours: evaluation of laser Doppler methods. 
  • Cell cycle-dependent expression of thyroid hormone receptor-beta is a mechanism for variable hormone sensitivity. 
  • Cervical precancer detection using a multivariate statistical algorithm based on laser-induced fluorescence spectra at multiple excitation wavelengths. 
  • Choroidal (subretinal) neovascularization secondary to choroidal nevus and successful treatment with argon laser photocoagulation. Case reports and review of literature. 
  • Comparative dose evaluations between XVI and OBI cone beam CT systems using Gafchromic XRQA2 film and nanoDot optical stimulated luminescence dosimeters. 
  • Comparing stereometric parameters between Heidelberg Retinal Tomography 2 and 3 in Asian eyes: the Singapore Malay Eye Study. 
  • Comparison of Laser Doppler and Laser-Assisted Indocyanine Green Angiography Prediction of Flap Survival in a Novel Modification of the McFarlane Flap. 
  • Comparison of algorithms for detection of localised nerve fibre layer defects using scanning laser polarimetry. 
  • Comparison of macular versus paramacular retinal sensitivity to femtosecond laser pulses. 
  • Comparison of retinal nerve fiber layer and optic disc imaging for diagnosing glaucoma in patients suspected of having the disease. 
  • Comparison of scanning laser polarimetry using variable corneal compensation and retinal nerve fiber layer photography for detection of glaucoma. 
  • Confocal scanning laser ophthalmoscopy classifiers and stereophotograph evaluation for prediction of visual field abnormalities in glaucoma-suspect eyes. 
  • Detection of glaucoma using scanning laser polarimetry with enhanced corneal compensation. 
  • Detection of progressive retinal nerve fiber layer loss in glaucoma using scanning laser polarimetry with variable corneal compensation. 
  • Determinants of agreement between the confocal scanning laser tomograph and standardized assessment of glaucomatous progression. 
  • Development of a fluorescence detection system using optical parametric oscillator (OPO) laser excitation for in vivo diagnosis. 
  • Development of a multivariate statistical algorithm to analyze human cervical tissue fluorescence spectra acquired in vivo. 
  • Development of a new capillary electrophoresis-based fibre optic sensor. 
  • Development of biologic markers of response and assessment of antiangiogenic activity in a clinical trial of human recombinant endostatin. 
  • Diagnosing preperimetric glaucoma with spectral domain optical coherence tomography. 
  • Diagnostic accuracy of the Heidelberg Retina Tomograph for glaucoma a population-based assessment. 
  • Differential associations of myopia with major age-related eye diseases: the Singapore Indian Eye Study. 
  • Differential wiring of local excitatory and inhibitory synaptic inputs to islet cells in rat spinal lamina II demonstrated by laser scanning photostimulation. 
  • Direct observation of kinesin stepping by optical trapping interferometry. 
  • Distribution and determinants of ocular biometric parameters in an Asian population: the Singapore Malay eye study. 
  • Distribution of axial length and ocular biometry measured using partial coherence laser interferometry (IOL Master) in an older white population. 
  • Effects of 308 nanometer excimer laser energy on 316 L stainless-steel stents: implications for laser atherectomy of in-stent restenosis. 
  • Effects of pulse shaping in laser spectroscopy and nuclear magnetic resonance. 
  • Emergence of self-organized long-period fiber gratings in supercontinuum-generating optical fibers. 
  • Endoscopic fluorescence detection of high-grade dysplasia in Barrett's esophagus. 
  • Enhancement of persistent sodium current by internal fluorescence in isolated hippocampal neurons. 
  • Erbium:YAG (2.94 mum) laser effects on dental tissues. 
  • Evaluation of imaging properties of a laser film digitizer. 
  • Experimental and numerical analysis of short-pulse laser interaction with tissue phantoms containing inhomogeneities. 
  • Fabrication of multifaceted, micropatterned surfaces and image-guided patterning using laser scanning lithography. 
  • Facet-embedded thin-film III-V edge-emitting lasers integrated with SU-8 waveguides on silicon. 
  • Fatigue behavior of As-built selective laser melted titanium scaffolds with sheet-based gyroid microarchitecture for bone tissue engineering. 
  • Feasibility of laser targeted photo-occlusion of ocular vessels. 
  • Feasibility of laser-targeted photoocclusion of the choriocapillary layer in rats. 
  • Femtosecond phase-coherent two-dimensional spectroscopy. 
  • Femtosecond pulse train shaping improves two-photon excited fluorescence measurements 
  • Focusing of shock waves induced by optical breakdown in water. 
  • Forces for morphogenesis investigated with laser microsurgery and quantitative modeling. 
  • Fourier analysis of scanning laser polarimetry measurements with variable corneal compensation in glaucoma. 
  • Free-electron laser etching of dental enamel. 
  • Functional mapping of neurons that control locomotory behavior in Caenorhabditis elegans. 
  • Gastroenterology. Lasers come of age. 
  • Histogram-directed processing of digital chest images. 
  • Hydrogel-nanoparticle composites for optically modulated cancer therapeutic delivery. 
  • Imaging microscopic pigment chemistry in conjunctival melanocytic lesions using pump-probe laser microscopy. 
  • Imaging the behavior of molecules in biological systems: breaking the 3D speed barrier with 3D multi-resolution microscopy. 
  • Immunonanoshells for targeted photothermal ablation in medulloblastoma and glioma: an in vitro evaluation using human cell lines. 
  • Impact of atypical retardation patterns on detection of glaucoma progression using the GDx with variable corneal compensation. 
  • In vitro polymerization of tau protein monitored by laser light scattering: method and application to the study of FTDP-17 mutants. 
  • In vitro studies with a pulsed neodymium/YAG laser. 
  • In vivo cancer diagnosis of the esophagus using differential normalized fluorescence (DNF) indices. 
  • In vivo label-free photoacoustic flow cytography and on-the-spot laser killing of single circulating melanoma cells. 
  • In vivo magnetic resonance vascular imaging using laser-polarized 3He microbubbles. 
  • Inactivation of the MAL gene in breast cancer is a common event that predicts benefit from adjuvant chemotherapy. 
  • Induction of angiogenesis after TMR: a comparison of holmium: YAG, CO2, and excimer lasers. 
  • Influence of disease severity and optic disc size on the diagnostic performance of imaging instruments in glaucoma. 
  • Injuries to the bronchi and lungs caused by laser-ignited endotracheal tube fires. 
  • Intereye spatial relationship of abnormal neuroretinal rim locations in glaucoma patients from the diagnostic innovations in glaucoma study. 
  • Intraoperative angiography using laser-assisted indocyanine green imaging to map perfusion of forehead flaps. 
  • Intravascular optical coherence tomography light scattering artifacts: merry-go-rounding, blooming, and ghost struts. 
  • Is scanning laser polarimetry ready for clinical practice? 
  • Kidney stones: flexible ureteroscopy. 
  • Laser Doppler blood flow measurements of common cutaneous donor sites for reconstructive surgery. 
  • Laser scanning cytometry evaluation of MART-1, gp100, and HLA-A2 expression in melanoma metastases. 
  • Laser scanning cytometry quantification of estrogen receptors in breast cancer. 
  • Laser treatment in patients with bilateral large drusen: the complications of age-related macular degeneration prevention trial. 
  • Laser-Assisted Indocyanine Green Dye Angiography for Postoperative Fistulas After Salvage Laryngectomy. 
  • Laser-assisted extraction of pacemaker and defibrillator leads: the role of the cardiac surgeon. 
  • Laser-capture microdissection. 
  • Laser-enhanced NMR spectroscopy. 
  • Laser-induced fluorescence for esophageal cancer and dysplasia diagnosis. 
  • Laser-induced fluorescence spectroscopy for in vivo diagnosis of non-melanoma skin cancers. 
  • Laser-induced fluorescence spectroscopy: somewhere over the rainbow. 
  • Laser-induced fluorescence studies of polycyclic aromatic hydrocarbons (PAH) vapors at high temperatures. 
  • Laser-induced heating in optical traps. 
  • Laser-induced room-temperature phosphorescence detection of benzo[a]pyrene-DNA adducts. 
  • Laser-scanning lithography (LSL) for the soft lithographic patterning of cell-adhesive self-assembled monolayers. 
  • Lasers and microdermabrasion enhance and control topical delivery of vitamin C. 
  • Long-term variability of GDx VCC retinal nerve fiber layer thickness measurements. 
  • Loss of heterozygosity of M6P/IGF2R gene is an early event in the development of prostate cancer. 
  • Low power resonant optical excitation of an optomechanical cavity. 
  • MR imaging of microcirculation in rat brain: correlation with carbon dioxide-induced changes in blood flow. 
  • MR imaging with hyperpolarized 3He gas. 
  • Magnetic resonance angiography with hyperpolarized 129Xe dissolved in a lipid emulsion. 
  • Mass spectrometry of nucleic acids: the promise of matrix-assisted laser desorption-ionization (MALDI) mass spectrometry. 
  • Mechanical Properties of a Drosophila Larval Chordotonal Organ. 
  • Microsecond folding dynamics of the F13W G29A mutant of the B domain of staphylococcal protein A by laser-induced temperature jump. 
  • Molecular contrast in optical coherence tomography by use of a pump-probe technique. 
  • Mossy fiber-granule cell synapses in the normal and epileptic rat dentate gyrus studied with minimal laser photostimulation. 
  • Multiple forces contribute to cell sheet morphogenesis for dorsal closure in Drosophila. 
  • Need for Evidence and Consensus on Laser Treatment for Management of Select Primary Penile Tumors. 
  • Neuroblastoma grafts are noninvasively removed within mouse neocortex by selective laser activation of intracellular photolytic chromophore. 
  • Neutrophils plug capillaries in acute experimental retinal ischemia. 
  • New dendritic adhesives for sutureless ophthalmic surgical procedures: in vitro studies of corneal laceration repair. 
  • New techniques for imaging and analyzing lung tissue. 
  • Next generation non-vacuum, maskless, low temperature nanoparticle ink laser digital direct metal patterning for a large area flexible electronics. 
  • Non-invasive laser microsurgery selectively damages populations of labeled mouse neurons: dependence on incident laser dose and absorption. 
  • Noninvasive monitoring of cerebral oxygenation in preterm infants: preliminary observations. 
  • Noninvasive visualization of blood flow in the choriocapillaris of the rat. 
  • Noninvasive visualization of the choriocapillaris and its dynamic filling. 
  • Noninvasively induced degeneration of neocortical pyramidal neurons in vivo: selective targeting by laser activation of retrogradely transported photolytic chromophore. 
  • Optic disc melanocytoma and glaucoma. 
  • Pathology of macular lesions from subnanosecond pulses of visible laser energy. 
  • Performance evaluation of computed radiography systems. 
  • Phase-cycling coherent anti-Stokes Raman scattering using shaped femtosecond laser pulses 
  • Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles. 
  • Photoacoustic thermal flowmetry with a single light source. 
  • Photoreceptor synapses degenerate early in experimental choroidal neovascularization. 
  • Photothermal coagulation of blood vessels: a comparison of high-speed optical coherence tomography and numerical modelling. 
  • Physical penumbra change of beam profile due to film digitization. 
  • Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor. 
  • Potassium-induced enhancement of persistent inward current in hippocampal neurons in isolation and in tissue slices. 
  • Probing the folding and unfolding dynamics of secondary and tertiary structures in a three-helix bundle protein. 
  • Pulpal response to cavity preparation with the Er:YAG and Mark III free electron lasers. 
  • Quantitative analysis of axonal loss in band atrophy of the optic nerve using scanning laser polarimetry. 
  • Quantitative detection of glaucomatous damage at the posterior pole by retinal thickness mapping. A pilot study. 
  • Quantitative expression profile of PSGR in prostate cancer. 
  • Range image statistics can explain the anomalous perception of length. 
  • Rapid Antimicrobial Susceptibility Testing Using Forward Laser Light Scatter Technology. 
  • Rapid double 8-nm steps by a kinesin mutant. 
  • Relationship between patterns of visual field loss and retinal nerve fiber layer thickness measurements. 
  • Relevance vector machine and support vector machine classifier analysis of scanning laser polarimetry retinal nerve fiber layer measurements. 
  • Remodeling Tissue Interfaces and the Thermodynamics of Zipping during Dorsal Closure in Drosophila. 
  • Reticular drusen associated with geographic atrophy in age-related macular degeneration. 
  • Retinal damage and laser-induced breakdown produced by ultrashort-pulse lasers. 
  • Retinal effects of ultrashort laser pulses in the rabbit eye. 
  • Retinal nerve fiber layer loss after traumatic optic neuropathy detected by scanning laser polarimetry. 
  • Retinal nerve fiber layer thickness and visual sensitivity using scanning laser polarimetry with variable and enhanced corneal compensation. 
  • Retinal nerve fiber layer thickness measurements with scanning laser polarimetry predict glaucomatous visual field loss. 
  • Retinal response of Macaca mulatta to picosecond laser pulses of varying energy and spot size. 
  • Saline infusion in excimer laser coronary angioplasty. 
  • Scanning laser polarimetry with enhanced corneal compensation for detection of axonal loss in band atrophy of the optic nerve. 
  • Selective laser-activated lesioning of prelabeled fetal hippocampal grafts by intracellular photolytic chromophore. 
  • Selective visualization of choroidal neovascular membranes. 
  • Self-phase modulation signatures of neuronal activity 
  • Sensitive analysis of [D-Pen2,5]enkephalin in rat serum by capillary electrophoresis and laser-induced fluorescence detection. 
  • Sensitive, label-free protein assay using 1-ethyl-3-methylimidazolium tetrafluoroborate-supported microchip electrophoresis with laser-induced fluorescence detection. 
  • Serial optical sectioning of macular holes at different stages of development. 
  • Servo control of an optical trap. 
  • Shock wave interaction with laser-generated single bubbles. 
  • Signals and noise in micromechanical measurements. 
  • Skull base training and education using an artificial skull model created by selective laser sintering. 
  • Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli. 
  • Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. 
  • Spectrally encoded confocal scanning laser ophthalmoscopy. 
  • Spectroscopic diagnosis of cervical intraepithelial neoplasia (CIN) in vivo using laser-induced fluorescence spectra at multiple excitation wavelengths. 
  • Spectroscopic diagnosis of esophageal cancer: new classification model, improved measurement system. 
  • Spectroscopy: shifting light with spin. 
  • Stabilization of continuum generation from normally dispersive nonlinear optical fibers for a tunable broad bandwidth source for optical coherence tomography. 
  • Staggered cell-intrinsic timing of ath5 expression underlies the wave of ganglion cell neurogenesis in the zebrafish retina. 
  • Stereolithography: a historical review and indications for use in the management of trauma. 
  • Structure-function relationships using confocal scanning laser ophthalmoscopy, optical coherence tomography, and scanning laser polarimetry. 
  • Surface-enhanced-Raman-scattering-inducing nanoprobe for spectrochemical analysis. 
  • Surgical atrial fibrillation ablation: a review of contemporary techniques and energy sources. 
  • Systemic toxicology and laser safety of laser targeted angiography with heat sensitive liposomes. 
  • Temperature alterations of infrared light absorption by cartilage and cornea under free-electron laser radiation. 
  • Temperature-sensitive hydrogels with SiO2-Au nanoshells for controlled drug delivery. 
  • Testing parallel laser image scaling for remotely measuring body dimensions on mantled howling monkeys (Alouatta palliata). 
  • The Relationship between intraocular pressure and progressive retinal nerve fiber layer loss in glaucoma. 
  • The current status of laser usage in ophthalmology. 
  • The effect of atypical birefringence patterns on glaucoma detection using scanning laser polarimetry with variable corneal compensation. 
  • The effect of laser treatment on skin to enhance and control transdermal delivery of 5-fluorouracil. 
  • The effect of surface topography and porosity on the tensile fatigue of 3D printed Ti-6Al-4V fabricated by selective laser melting. 
  • The effects of study design and spectrum bias on the evaluation of diagnostic accuracy of confocal scanning laser ophthalmoscopy in glaucoma. 
  • The influence of masseter and temporalis sarcomere length operating ranges as determined by laser diffraction on architectural estimates of muscle force and excursion in macaques (Macaca fascicularis and Macaca mulatta). 
  • The motion of a single molecule, the lambda-receptor, in the bacterial outer membrane. 
  • The secretory granule matrix-electrolyte interface: a homologue of the p-n rectifying junction. 
  • Thermal lens measurements in the cornea. 
  • Three-dimensional micropatterning of bioactive hydrogels via two-photon laser scanning photolithography for guided 3D cell migration. 
  • Thresholds for retinal injury from multiple near-infrared ultrashort laser pulses. 
  • Thresholds for visible lesions in the primate eye produced by ultrashort near-infrared laser pulses. 
  • Time-resolved optical tomography using short-pulse laser for tumor detection. 
  • Time-resolved, light scattering measurements of cartilage and cornea denaturation due to free electron laser radiation. 
  • Tissue ablation by a free-electron laser tuned to the amide II band. 
  • Trace molecular detection via surface-enhanced Raman scattering and surface-enhanced resonance Raman scattering at a distance of 15 meters. 
  • Transdermal delivery of macromolecules by erbium:YAG laser. 
  • Transdermal drug delivery enhanced and controlled by erbium:YAG laser: a comparative study of lipophilic and hydrophilic drugs. 
  • Transfer of molecules from glia to axon in the squid may be mediated by glial vesicles. 
  • Two-dimensional tracking of ncd motility by back focal plane interferometry. 
  • Two-photon absorption and self-phase modulation measurements with shaped femtosecond laser pulses 
  • Ultrashort laser pulse bioeffects and safety. 
  • Ultraviolet surface-enhanced Raman scattering at the plasmonic band edge of a metallic grating. 
  • Unfocused laser illumination kills dye-targeted mouse neurons by selective photothermolysis. 
  • Use of laser scanning cytometry to study tumor microenvironment. 
  • Use of progressive glaucomatous optic disk change as the reference standard for evaluation of diagnostic tests in glaucoma. 
  • Visible retinal lesions from ultrashort laser pulses in the primate eye. 
  • Visual field progression. 
  • p53 Immunostaining guided laser capture microdissection (p53-LCM) defines the presence of p53 gene mutations in focal regions of primary prostate cancer positive for p53 protein. 
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  Keywords of People

  • Brys, Adam, Assistant Professor of Dermatology, Dermatology
  • Driehuys, Bastiaan, Professor of Radiology, Biomedical Engineering
  • Fischer, Martin, Associate Research Professor in the Department of Chemistry, Chemistry
  • Jokerst, Nan Marie, J. A. Jones Distinguished Professor of Electrical and Computer Engineering, Duke University Energy Initiative
  • Jowell, Paul Simon, Professor of Medicine, Medicine, Gastroenterology
  • McCall, Shannon Jones, Associate Professor of Pathology, Pathology
  • Mruthyunjaya, Prithvi, Adjunct Associate Professor in the Department of Ophthalmology, Ophthalmology, Vitreoretinal Diseases & Surgery
  • Palmer, Gregory M., Associate Professor of Radiation Oncology, Radiation Oncology
  • Stinnett, Sandra Sue, Associate Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics
  • Suggs, Amanda Kristine, Assistant Professor of Dermatology, Dermatology
  • Toth, Cynthia Ann, Joseph A.C. Wadsworth Distinguished Professor of Ophthalmology, Biomedical Engineering
  • Tsalik, Ephraim, Associate Professor of Medicine, Molecular Genetics and Microbiology
  • Zhong, Pei, Professor in the Department of Mechanical Engineering and Materials Science, Mechanical Engineering and Materials Science