Leiomyoma

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  Subject Areas on Research

  • A Comparative Analysis of Health-Related Quality of Life 1 Year Following Myomectomy or Uterine Artery Embolization: Findings from the COMPARE-UF Registry. 
  • A Phase I Clinical Trial to Assess Safety and Tolerability of Injectable Collagenase in Women with Symptomatic Uterine Fibroids. 
  • A flexible parametric model for combining current status and age at first diagnosis data. 
  • A new hypothesis about the origin of uterine fibroids based on gene expression profiling with microarrays. 
  • A proportional hazards model for incidence and induced remission of disease. 
  • ACR Appropriateness Criteria® Radiologic Management of Uterine Leiomyomas. 
  • Acoustic shadowing from uterine leiomyomas: sonographic-pathologic correlation. 
  • Addressing heterogenous outcomes in uterine fibroid research: a call to action. 
  • Advances in uterine leiomyoma research: conference overview, summary, and future research recommendations. 
  • Allelic loss at the tuberous sclerosis 2 locus in spontaneous tumors in the Eker rat. 
  • Allelotype analysis of uterine leiomyoma: localization of a potential tumor suppressor gene to a 4-cM region of chromosome 7q. 
  • An unexpected intraoperative finding. 
  • Analysis of genetic alterations in uterine leiomyomas and leiomyosarcomas by comparative genomic hybridization. 
  • Association Between Patient Characteristics and Treatment Procedure Among Patients With Uterine Leiomyomas. 
  • Association of physical activity with development of uterine leiomyoma. 
  • Authors' response to letter to the editor: the role of core outcomes in shared decision-making for uterine fibroid treatment. 
  • Bayesian modeling of incidence and progression of disease from cross-sectional data. 
  • Bayesian models for multivariate current status data with informative censoring. 
  • Benign gynecologic conditions are associated with ovarian cancer risk in African-American women: a case-control study. 
  • Benign prostatic hypertrophy and uterine leiomyomas: analogous or dissimilar diseases? 
  • Bizarre leiomyoma of the posterior vaginal fornix. 
  • Black Women Are More Likely Than White Women to Schedule a Uterine-Sparing Treatment for Leiomyomas. 
  • Bladder leiomyoma: advantages of sonography over computed tomography. 
  • CDB-4124 does not cause apoptosis in cultured fibroid cells. 
  • Cell proliferation and apoptosis in human uterine leiomyomas and myometria. 
  • Comparative effectiveness of hysterectomy versus myomectomy on one-year health-related quality of life in women with uterine fibroids. 
  • Comparative effectiveness of uterine fibroids procedures using linked medical record and claims data. 
  • Comparative ultrastructure of collagen fibrils in uterine leiomyomas and normal myometrium. 
  • Comparing focused ultrasound and uterine artery embolization for uterine fibroids-rationale and design of the Fibroid Interventions: reducing symptoms today and tomorrow (FIRSTT) trial. 
  • Comparison of characteristics of fibroids in African American and white women undergoing premenopausal hysterectomy. 
  • Cost analysis of abdominal, laparoscopic, and robotic-assisted myomectomies. 
  • Development of a research agenda for uterine artery embolization: proceedings from a multidisciplinary research consensus panel. 
  • Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas. 
  • Disparities in Fibroid Incidence, Prognosis, and Management. 
  • Effect of Direct Marketing for Uterine Artery Embolization on Rates of Leiomyomas, Incidental Findings, and Management After Pelvic MRI. 
  • Effects of myomas or prior myomectomy on in vitro fertilization (IVF) performance. 
  • Effects of race and clinical factors on short-term outcomes of abdominal myomectomy. 
  • Eligibility and accessibility of magnetic resonance-guided focused ultrasound (MRgFUS) for the treatment of uterine leiomyomas. 
  • Embolic microspheres within ovarian arterial vasculature after uterine artery embolization. 
  • Endoscopic management of leiomyomata. 
  • Epidemiology of myomas. 
  • Epidemiology of uterine leiomyomas. With an etiologic hypothesis. 
  • Epididymal leiomyoma: sonographic features. 
  • Estrogen stimulation and tamoxifen inhibition of leiomyoma cell growth in vitro and in vivo. 
  • Estrogen/antiestrogen responsiveness in an in vivo/in vitro model for myometrial tumorigenesis. 
  • Evidence of biomechanical and collagen heterogeneity in uterine fibroids. 
  • Expression of a mitochondrial progesterone receptor (PR-M) in leiomyomata and association with increased mitochondrial membrane potential. 
  • Extracellular matrix and Hippo signaling as therapeutic targets of antifibrotic compounds for uterine fibroids. 
  • FIRSTT study: randomized controlled trial of uterine artery embolization vs focused ultrasound surgery. 
  • Fibroid interventions: reducing symptoms today and tomorrow: extending generalizability by using a comprehensive cohort design with a randomized controlled trial. 
  • Fibroids and Fertility: A Comparison of Myomectomy and Uterine Artery Embolization on Fertility and Reproductive Outcomes. 
  • Fibroids in pregnancy: a growing or shrinking issue? 
  • Gadobenate dimeglumine-enhanced magnetic resonance imaging of primary leiomyoma of the liver. 
  • Gene expression studies in leiomyomata: new directions for research. 
  • Giant pelvic retroperitoneal leiomyoma arising from the rectal wall. 
  • Giant uterine leiomyoma mimicking pregnancy. 
  • Health care resource use for uterine fibroid tumors in the United States. 
  • High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence. 
  • Impact of precontrast T10 relaxation times on dynamic contrast-enhanced MRI pharmacokinetic parameters: T10 mapping versus a fixed T10 reference value. 
  • Incidence and risk factors for surgical intervention after uterine artery embolization. 
  • Injectable Clostridium histolyticum collagenase as a potential treatment for uterine fibroids. 
  • Inter- and intra-rater reproducibility of quantitative dynamic contrast enhanced MRI using TWIST perfusion data in a uterine fibroid model. 
  • July 2002: 66-year-old female with a one-year history of progressive left proptosis. 
  • Large, Non-Cavity Distorting Intramural Leiomyomas Decrease Leukemia Inhibitory Factor in the Secretory Phase Endometrium. 
  • Leiomyoma involving the gastrocolic ligament: CT demonstration. 
  • Leiomyoma-related hospitalization and surgery: prevalence and predicted growth based on population trends. 
  • Leiomyomas of the fallopian tube. A case report. 
  • Loss of stiffness in collagen-rich uterine fibroids after digestion with purified collagenase Clostridium histolyticum. 
  • Luteinizing hormone in premenopausal women may stimulate uterine leiomyomata development. 
  • Management of uterine fibroids. 
  • Management of uterine leiomyomata: what do we really know? 
  • Mechanical Signaling and Extracellular Matrix in Uterine Fibroids. 
  • Mechanical homeostasis is altered in uterine leiomyoma. 
  • Myometrial hyperplasia mimics the clinical presentation of uterine fibroids: a report of 3 cases. 
  • On the Road to Safer Morcellation. 
  • Pathology and pathophysiology of uterine smooth-muscle tumors. 
  • Patterns and predictors of vaginal bleeding in the first trimester of pregnancy. 
  • Pedunculated scrotal mass: leiomyoma of scrotum. 
  • Pelvic mass presenting as meralgia paresthetica. 
  • Periprocedural outcomes comparing fibroid embolization and focused ultrasound: a randomized controlled trial and comprehensive cohort analysis. 
  • Polycystic kidney disease as a result of loss of the tuberous sclerosis 2 tumor suppressor gene during development. 
  • Potential nonhormonal therapeutics for medical treatment of leiomyomas. 
  • Preclinical evidence for therapeutic efficacy of selective estrogen receptor modulators for uterine leiomyoma. 
  • Pregnancy-related fibroid reduction. 
  • Preliminary experience with robot-assisted laparoscopic myomectomy. 
  • Preservation of the endometrial enhancement after magnetic resonance imaging-guided high-intensity focused ultrasound ablation of submucosal uterine fibroids. 
  • Prevalence of uterine leiomyomas in the first trimester of pregnancy: an ultrasound-screening study. 
  • Primary intracranial leiomyoma in an immunocompetent patient. 
  • Primary leiomyoma of the liver. 
  • Prospective data collection of a new procedure by a specialty society: the FIBROID registry. 
  • Proteoglycans in Leiomyoma and Normal Myometrium: Abundance, Steroid Hormone Control, and Implications for Pathophysiology. 
  • Proteoglycans of uterine fibroids and keloid scars: similarity in their proteoglycan composition. 
  • Racial diversity in uterine leiomyoma clinical studies. 
  • Reduced dermatopontin expression is a molecular link between uterine leiomyomas and keloids. 
  • Refractory shadowing from pelvic masses on sonography: a useful diagnostic sign for uterine leiomyomas. 
  • Reproducibility of dynamic contrast-enhanced MR imaging. Part I. Perfusion characteristics in the female pelvis by using multiple computer-aided diagnosis perfusion analysis solutions. 
  • Reproducibility of dynamic contrast-enhanced MR imaging. Part II. Comparison of intra- and interobserver variability with manual region of interest placement versus semiautomatic lesion segmentation and histogram analysis. 
  • Reproductive Functions of the Mitochondrial Progesterone Receptor (PR-M). 
  • Risk factors for postoperative urinary retention after laparoscopic and robotic hysterectomy for benign indications. 
  • Risk of benign gynecologic tumors in relation to prenatal diethylstilbestrol exposure. 
  • Risk of unanticipated abnormal gynecologic pathology at the time of hysterectomy for uterovaginal prolapse. 
  • Rodent model of reproductive tract leiomyomata. Clinical and pathological features. 
  • Rodent model of reproductive tract leiomyomata. Establishment and characterization of tumor-derived cell lines. 
  • Rodent model of reproductive tract leiomyomata: characterization and use in preclinical therapeutic studies. 
  • Route of myomectomy and fertility: a prospective cohort study. 
  • Safety and efficacy of the selective progesterone receptor modulator asoprisnil for heavy menstrual bleeding with uterine fibroids: pooled analysis of two 12-month, placebo-controlled, randomized trials. 
  • Screening Magnetic Resonance Imaging-Based Prediction Model for Assessing Immediate Therapeutic Response to Magnetic Resonance Imaging-Guided High-Intensity Focused Ultrasound Ablation of Uterine Fibroids. 
  • Sebaceous glands - unusual histological finding in the uterine cervix. 
  • Self-report versus ultrasound measurement of uterine fibroid status. 
  • Semiparametric bayes' proportional odds models for current status data with underreporting. 
  • Short-Term Health-Related Quality of Life After Hysterectomy Compared With Myomectomy for Symptomatic Leiomyomas. 
  • Short-term quality of life after myomectomy for uterine fibroids from the COMPARE-UF Fibroid Registry. 
  • Simplified pain-control protocol after uterine artery embolization. 
  • Sonography of benign cystic teratoma of the ovary: pitfalls in diagnosis. 
  • Strategy for elucidating differentially expressed genes in leiomyomata identified by microarray technology. 
  • Subungual leiomyoma in the left thumb of a 16-year-old female. 
  • Summary of the Proceedings of the Basic Science of Uterine Fibroids Meeting: New Developments February 28, 2020. 
  • Surgical validation of angiographic studies of renal lesions. 
  • Synchronous bilateral testicular tumour: nonseminomatous germ cell tumours and contralateral benign tumours. 
  • Systematic review highlights difficulty interpreting diverse clinical outcomes in abnormal uterine bleeding trials. 
  • The Comparing Options for Management: PAtient-centered REsults for Uterine Fibroids (COMPARE-UF) registry: rationale and design. 
  • The FIBROID Registry: symptom and quality-of-life status 1 year after therapy. 
  • The Fibroid Registry for outcomes data (FIBROID) for uterine embolization: short-term outcomes. 
  • The Prevalence of Uterine Fibroids in African American Women with Hemoglobin SS Sickle Cell Disease as Determined by Pelvic Magnetic Resonance Imaging. 
  • The impact of surgeon volume on perioperative adverse events in women undergoing minimally invasive hysterectomy for the large uterus. 
  • The promise and perils of microarray analysis. 
  • Thrombospondin-1 and thrombospondin-2 mRNA and TSP-1 and TSP-2 protein expression in uterine fibroids and correlation to the genes COL1A1 and COL3A1 and to the collagen cross-link hydroxyproline. 
  • Transforming growth factor beta3 regulates the versican variants in the extracellular matrix-rich uterine leiomyomas. 
  • Tumor-specific efficacy of transforming growth factor-beta RI inhibition in Eker rats. 
  • Type 2 angiotensin II receptor is expressed in human myometrium and uterine leiomyoma and is down-regulated during pregnancy. 
  • Using rheology to quantify the effects of localized collagenase treatments on uterine fibroid digestion. 
  • Uterine Fibroids: Burden and Unmet Medical Need. 
  • Uterine artery embolisation for IVC syndrome and severe lower extremity oedema secondary to IVC compression from massive fibroids. 
  • Uterine artery embolization: what more do we need to know? 
  • Uterine fibroids: Influence of "T2-Rim sign" on immediate therapeutic responses to magnetic resonance imaging-guided high-intensity focused ultrasound ablation. 
  • Uterine leiomyoma in a 14-year-old girl. 
  • Uterine leiomyoma in the Eker rat: a unique model for important diseases of women. 
  • Uterine leiomyomata in relation to insulin-like growth factor-I, insulin, and diabetes. 
  • Vitamin D and uterine leiomyomata: Is it time to let the sunshine in? 
  • Vitamin D inhibits proliferation of human uterine leiomyoma cells via catechol-O-methyltransferase. 
  • Von Willebrand disease. 
  • Why is parity protective for uterine fibroids? 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Moorman, Patricia Gripka, Professor Emeritus in Family Medicine and Community Health, Duke Cancer Institute
  • Myers, Evan Robert, Walter L. Thomas Distinguished Professor of Obstetrics and Gynecology in the School of Medicine, Duke Cancer Institute