Lens, Crystalline

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  Subject Areas on Research

  • A Frag Bag for Efficient Removal of Dislocated Nuclear Material. 
  • A comparison of neodymium: yttrium aluminum garnet and diode laser transscleral cyclophotocoagulation and cyclocryotherapy. 
  • ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory. 
  • Abnormal creatine transport of mutations in monocarboxylate transporter 12 (MCT12) found in patients with age-related cataract can be partially rescued by exogenous chaperone CD147. 
  • Abundant expression of ponsin, a focal adhesion protein, in lens and downregulation of its expression by impaired cytoskeletal signaling. 
  • Adducin: Ca++-dependent association with sites of cell-cell contact. 
  • An automatic diagnosis system of nuclear cataract using slit-lamp images. 
  • An experimental model of ectropion uveae and iris neovascularization in the cat. 
  • Analysis of small GTP-binding proteins of the lens by GTP overlay assay reveals the presence of unique GTP-binding proteins associated with fiber cells. 
  • Ankyrin-B directs membrane tethering of periaxin and is required for maintenance of lens fiber cell hexagonal shape and mechanics. 
  • Ankyrin-B in lens architecture and biomechanics: Just not tethering but more. 
  • Ankyrin-G regulated epithelial phenotype is required for mouse lens morphogenesis and growth. 
  • Anterior chamber width measurement by high-speed optical coherence tomography. 
  • Automatic Feature Learning to Grade Nuclear Cataracts Based on Deep Learning. 
  • Autophagy and mitophagy participate in ocular lens organelle degradation. 
  • Autosomal dominant cataracts of the fetus: early detection by transvaginal ultrasound. 
  • BMP4 is essential for lens induction in the mouse embryo. 
  • Betaine-homocysteine methyltransferase is a developmentally regulated enzyme crystallin in rhesus monkey lens. 
  • Bi-directional migration of lens epithelial cells in a physiological electrical field. 
  • Brain ankyrin. Purification of a 72,000 Mr spectrin-binding domain. 
  • C-phycocyanin modulates selenite-induced cataractogenesis in rats. 
  • Carbonyl-metabolizing enzymes and their relatives recruited as structural proteins in the eye lens. 
  • Cataract conversion assessment using lens opacity classification system III and Wisconsin cataract grading system. 
  • Cataract formation in a strain of rats selected for high oxidative stress. 
  • Characterization of intraocular immunopathology following intracameral inoculation with alloantigen. 
  • Characterization of lens fiber cell triton insoluble fraction reveals ERM (ezrin, radixin, moesin) proteins as major cytoskeletal-associated proteins. 
  • Condensation on polymethylmethacrylate, acrylic polymer, and silicone intraocular lenses after fluid-air exchange in rabbits. 
  • Control of lens epithelial cell survival. 
  • Corneal perforation with secondary congenital aphakia in Peters anomaly. 
  • Cytologic findings in vitreous fluids. Analysis of 74 specimens. 
  • Cytoprotective effects of proteasome beta5 subunit overexpression in lens epithelial cells. 
  • Delayed radiation necrosis of the optic nerve. 
  • Developmental analysis of ocular morphogenesis in alpha A-crystallin/diphtheria toxin transgenic mice undergoing ablation of the lens. 
  • Diagnosis of phacoanaphylactic endophthalmitis by fine needle aspiration biopsy. 
  • Diagnostic ultrasound and pars plana vitrectomy in penetrating ocular trauma. 
  • Distribution and type of morphological damage in human nuclear age-related cataracts. 
  • Distribution of gap junctions and square array junctions in the mammalian lens. 
  • Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis. 
  • Effect of perillic acid, a putative isoprenylation inhibitor, on the cultured rat lens. 
  • Effect of the isoflavone genistein against galactose-induced cataracts in rats. 
  • Electric fields and MAP kinase signaling can regulate early wound healing in lens epithelium. 
  • Endocapsular hypopyon: a clinical sign of localized endophthalmitis. 
  • Endophthalmitis after penetrating trauma. Risk factors and visual acuity outcomes. 
  • Enzyme/crystallins and extremely high pyridine nucleotide levels in the eye lens. 
  • Evaluation of a delivery system providing long-term release of cyclosporine. 
  • Evidence for independent recruitment of zeta-crystallin/quinone reductase (CRYZ) as a crystallin in camelids and hystricomorph rodents. 
  • Evidence that alpha-crystallin prevents non-specific protein aggregation in the intact eye lens. 
  • Evolution of graded refractive index in squid lenses. 
  • Experimental iridotomy with the Q-switched neodymium-YAG laser. 
  • Expression of nonphagocytic NADPH oxidase system in the ocular lens. 
  • Extremely high levels of NADPH in guinea pig lens: correlation with zeta-crystallin concentration. 
  • Eye dose assessment and management: overview. 
  • Eye dosimetry in interventional radiology and cardiology: current challenges and practical considerations. 
  • Eye injuries associated with paintball guns. 
  • Femtosecond cataract laser capsulotomy enabling optic capture and secondary sulcus iol insertion in an eye with traumatic aniridia and aphakia. 
  • Femtosecond laser-assisted cataract surgery in a subluxated traumatic cataract. 
  • Fluocinolone acetonide implant (Retisert) for noninfectious posterior uveitis: thirty-four-week results of a multicenter randomized clinical study. 
  • Freeze-fracture methods: preparation of complementary replicas for evaluating intracellular ice damage in ultrarapidly cooled specimens. 
  • Glaucoma following cataract surgery in children: surgically modifiable risk factors. 
  • Glutathione in calf trabecular meshwork and its relation to aqueous humor outflow facility. 
  • Glyceraldehyde 3-phosphate dehydrogenase is an enzyme-crystallin in diurnal geckos of the genus Phelsuma. 
  • Gross examination and photography. A technique for studying lenticular structure in enucleated eyes. 
  • Growth factor induced activation of Rho and Rac GTPases and actin cytoskeletal reorganization in human lens epithelial cells. 
  • Guinea pig and bovine zeta-crystallins have distinct functional characteristics highlighting replacements in otherwise similar structures. 
  • High level of ferritin light chain mRNA in lens. 
  • Identification and Ultrastructural Characterization of a Novel Nuclear Degradation Complex in Differentiating Lens Fiber Cells. 
  • Identification and characterization of the enzymatic activity of zeta-crystallin from guinea pig lens. A novel NADPH:quinone oxidoreductase. 
  • Image based diagnosis of cortical cataract. 
  • Impaired cytoskeletal organization and membrane integrity in lens fibers of a Rho GTPase functional knockout transgenic mouse. 
  • Increased retinal oxygen supply following pan-retinal photocoagulation and vitrectomy and lensectomy. 
  • Influence of Managed Care on the Variation in Rate and Timing of Cataract Surgery-Reply. 
  • Inhibition of Rho-kinase induces alphaB-crystallin expression in lens epithelial cells. 
  • Inhibition of proliferating lens epithelium with antitransferrin receptor immunotoxin. 
  • Intraocular cyclophotocoagulation. Histopathologic evaluation in primates. 
  • Intraocular injection of recombinant hirudin to prevent experimental postoperative fibrin. 
  • Investigations into the loss of glutathione from lenses in organ culture. 
  • Iron homeostasis and toxicity in retinal degeneration. 
  • Is there a latent period for the surgical treatment of children with dense bilateral congenital cataracts? 
  • L-type calcium channels play a critical role in maintaining lens transparency by regulating phosphorylation of aquaporin-0 and myosin light chain and expression of connexins. 
  • Lens capsular cyst. 
  • Lens fiber cell elongation and differentiation is associated with a robust increase in myosin light chain phosphorylation in the developing mouse. 
  • Lens status influences the association between CFH polymorphisms and age-related macular degeneration: findings from two population-based studies in Singapore. 
  • Lens vault, thickness, and position in Chinese subjects with angle closure. 
  • Lensectomy and vitrectomy decrease the rate of photoreceptor loss in rhodopsin P347L transgenic pigs. 
  • Light microscopic variation of fiber cell size, shape and ordering in the equatorial plane of bovine and human lenses. 
  • Lightning maculopathy. A case report. 
  • Lovastatin-induced cytoskeletal reorganization in lens epithelial cells: role of Rho GTPases. 
  • Management of the posterior capsule during pediatric intraocular lens implantation. 
  • Membrane specializations in mammalian lens fiber cells: distribution of square arrays. 
  • Methionine adenosyltransferase and S-adenosylmethionine in the developing rat lens. 
  • Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens. 
  • Microwave refraction in the eye. 
  • Morphology of the normal human lens. 
  • Neovascularization of the iris: an experimental model in cats. 
  • Novel use of bovine zeta-crystallin as a conformational DNA probe to characterize a phase transition zone and terminally differentiating fiber cells in the adult canine ocular lens. 
  • Ocular component growth curves among Singaporean children with different refractive error status. 
  • Ocular parameters of biological ageing in HIV-infected individuals in South Africa: relationship with chronological age and systemic biomarkers of ageing. 
  • On the structural organization of isolated bovine lens fiber junctions. 
  • Organization of the human zeta-crystallin/quinone reductase gene (CRYZ). 
  • Pax6- and Six3-mediated induction of lens cell fate in mouse and human ES cells. 
  • Periaxin is required for hexagonal geometry and membrane organization of mature lens fibers. 
  • Peripheral retinal cryotherapy for postvitrectomy diabetic vitreous hemorrhage in phakic eyes. 
  • Persistent fetal ocular vasculature in mice deficient in bax and bak. 
  • Phthisis bulbi after lensectomy in retinopathy of prematurity eyes previously treated with laser photocoagulation. 
  • Polyol and vacuole formation in cultured canine lens epithelial cells. 
  • Posterior capsule rupture following closed globe injury: Scheimpflug imaging, pathogenesis, and management. 
  • Posterior dislocation of a crystalline lens associated with airbag deployment. 
  • Powerful ideas driven by simple tools: lessons from experimental embryology. 
  • Proteomic analysis of regenerated rabbit lenses reveal crystallin expression characteristic of adult rabbits. 
  • Qa-1, a nonclassical MHC molecule with immunomodulatory functions, is ubiquitously expressed in the immune-privileged anterior chamber of the eye. 
  • Quasielastic light scattering study of the living human lens as a function of age. 
  • Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival. 
  • Radiation and cataract. 
  • Radiation-induced eye lens changes and risk for cataract in interventional cardiology. 
  • Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis. 
  • Re-orientation and faster, directed migration of lens epithelial cells in a physiological electric field. 
  • Real-time optical coherence tomography of the anterior segment at 1310 nm. 
  • Recombinant hirudin for prevention of experimental postoperative intraocular fibrin. 
  • Refractive changes after pediatric intraocular lens implantation. 
  • Resveratrol prevention of oxidative stress damage to lens epithelial cell cultures is mediated by forkhead box O activity. 
  • Rho GDP dissociation inhibitor-mediated disruption of Rho GTPase activity impairs lens fiber cell migration, elongation and survival. 
  • Rho GTPase inactivation impairs lens growth and integrity. 
  • Risk for radiation-induced cataract for staff in interventional cardiology: is there reason for concern? 
  • Role of scheimpflug imaging in traumatic intralenticular foreign body. 
  • Role of small GTP-binding proteins in lovastatin-induced cataracts. 
  • Selective expression of the small GTPase RhoB in the early developing mouse lens. 
  • Small eyes (Sey): a homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse. 
  • Sorting of lens aquaporins and connexins into raft and nonraft bilayers: role of protein homo-oligomerization. 
  • Spectral studies on normal and cataractous intact human lenses. 
  • Statin expression associated with terminally differentiating and postreplicative lens epithelial cells. 
  • Structural evidence of human nuclear fiber compaction as a function of ageing and cataractogenesis. 
  • Switching of α-Catenin From Epithelial to Neuronal Type During Lens Epithelial Cell Differentiation. 
  • The effect of Rho-associated kinase inhibition on the ocular penetration of timolol maleate. 
  • The effect of intraocular irrigating solutions on lens clarity in normal and diabetic rabbits. 
  • The effect of intraocular silicone oil on anterior chamber oxygen pressure in cats. 
  • The function of intraocular color filters. 
  • The lens epithelium contains glial fibrillary acidic protein (GFAP). 
  • The pulling, pushing and fusing of lens fibers: a role for Rho GTPases. 
  • The role of the lens actin cytoskeleton in fiber cell elongation and differentiation. 
  • The specialized junctions of the lens. 
  • The structural organization and protein composition of lens fiber junctions. 
  • The structure of junctions between lens fiber cells. 
  • The water permeability of lens aquaporin-0 depends on its lipid bilayer environment. 
  • Towards automatic grading of nuclear cataract. 
  • Transcriptional regulation of crystallin, redox, and apoptotic genes by C-Phycocyanin in the selenite-induced cataractogenic rat model. 
  • Transgenic mice expressing a constitutively active retinoic acid receptor in the lens exhibit ocular defects. 
  • Tryptophan excited states and cataracts in the human lens. 
  • Ultrastructural analysis of the human lens fiber cell remodeling zone and the initiation of cellular compaction. 
  • Ultrastructural characterization and Fourier analysis of fiber cell cytoplasm in the hyperbaric oxygen treated guinea pig lens opacification model. 
  • Ultrastructure of fiber cells and multilamellar inclusions in experimental diabetes. 
  • Unilateral electric cataract: Scheimpflug imaging and review of the literature. 
  • Visual acuity in pelagic fishes and mollusks. 
  • Vitrectomy, lensectomy, and ocular oxygenation. 
  • Wnt-signaling in retinal development and disease. 
  • Xenobiotic induction of quinone oxidoreductase activity in lens epithelial cells. 
  • Zeta-crystallin from guinea pig lens is capable of functioning catalytically as an oxidoreductase. 
  • Zeta-crystallin: a lens-specific promoter and the gene recruitment of an enzyme as a crystallin. 
  • [A study of suitable age for intraocular lens implantation in children according to ocular anatomy and development]. 
  • alpha-Crystallin localizes to the leading edges of migrating lens epithelial cells. 
  • zeta-Crystallin is a major protein in the lens of Camelus dromedarius. 
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  Keywords of People

  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Hogan, Brigid L. M., George Barth Geller Professor, Cell Biology
  • Liton, Paloma Borrajo, Associate Professor in Ophthalmology, Pathology