Lethal Dose 50

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  Subject Areas on Research

  • 3-Halo-5,7-dimethylpyrazolo [1,5-a]pyrimidines, a nonbenzodiazepinoid class of antianxiety agents devoid of potentiation of central nervous system depressant effects of ethanol or barbiturates. 
  • Acetylenics. 2. Synthesis and pharmacology of certain N,N-diakyl-3-phenylpropyn-2-amines. Some analogues with tryptamine-like behavioral effects in mice. 
  • Antineoplastic activity of a series of boron analogues of alpha-amino acids. 
  • Blocking [211At]astatide accumulation in normal tissues: preliminary evaluation of seven potential compounds. 
  • Caenorhabditis elegans as a Model for Toxic Effects of Nanoparticles: Lethality, Growth, and Reproduction. 
  • Chronopharmacology of strychnine and allylglycine in the mouse. 
  • Comparative toxicities of selected compounds to nauplii of Balanus amphitrite amphitrite Darwin and Artemia sp. 
  • Comparison of the in vitro sensitivity of rat acetylcholinesterase to chlorpyrifos-oxon: what do tissue IC50 values represent? 
  • Differential developmental toxicity of naphthoic acid isomers in medaka (Oryzias latipes) embryos. 
  • Diurnal variations in the toxicity and tissue levels of spermidine in mice. 
  • Drugs derived from cannabinoids. 2. Basic esters of nitrogen and carbocyclic analogs. 
  • Early zebrafish embryogenesis is susceptible to developmental TDCPP exposure. 
  • Effect of sulfur substitution for the noncarbonyl oxygen in hemicholinium-3 and acetyl-seco-hemicholinium-3. Synthesis, biological activity, and structure-toxicity relationships. 
  • Effects of dietary exposure to the pyrethroid pesticide esfenvalerate on medaka (Oryzias latipes). 
  • Embryo toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin to the wood duck (Aix sponsa). 
  • Evaluating the zebrafish embryo toxicity test for pesticide hazard screening. 
  • Increasing uptake and bioactivation with development positively modulate diazinon toxicity in early life stage medaka (Oryzias latipes). 
  • Joint acute toxicity of esfenvalerate and diazinon to larval fathead minnows (Pimephales promelas). 
  • Local anesthetic activity and acute toxicity of N-heptyl-1,2,3,4-tetrahydro-6-methoxy-1-naphthylamine methanesulfonate. 
  • Local anesthetic activity and acute toxicity of N-substituted 1,2,3,4-tetrahydro-1- and 2-naphthylamines. 
  • Oral toxicity of the cyclic polyethers--12-crown-4, 15-crown-5, and 18-crown-6--in mice. 
  • Patterns of heritability of decreased EROD activity and resistance to PCB 126-induced teratogenesis in laboratory-reared offspring of killifish (Fundulus heteroclitus) from a creosote-contaminated site in the Elizabeth River, VA, USA. 
  • Peptidyl membrane-interactive molecules are cytotoxic to prostatic cancer cells in vitro. 
  • Photoperiodic adjustments in immune function protect Siberian hamsters from lethal endotoxemia. 
  • Reduced arsenic clearance and increased toxicity in aquaglyceroporin-9-null mice. 
  • Remodeling Yersinia pseudotuberculosis to generate a highly immunogenic outer membrane vesicle vaccine against pneumonic plague. 
  • Review of international criteria and mixture rules for health hazard classification. 
  • Silver nanoparticle toxicity is related to coating materials and disruption of sodium concentration regulation. 
  • Sulfidation of silver nanoparticles: natural antidote to their toxicity. 
  • Synergistic cytotoxicity with 2'-deoxy-5-azacytidine and topotecan in vitro and in vivo. 
  • Synthesis and structure-toxicity relationships of three new stable analogues of acetyl-seco-hemicholinium-3. 
  • Synthesis, biological activity, and structure--activity/toxicity relationships of a series of terphenyl analogues of hemicholinium-3 and acetyl-seco-hemicholinium-3. 3. 
  • The inflammatory response and resistance to endotoxin in mice. 
  • Toxicity of a formulation of the insecticide indoxacarb to the tarnished plant bug, Lygus lineolaris (Hemiptera: Miridae), and the big-eyed bug, Geocoris punctipes (Hemiptera: Lygaeidae). 
  • Toxicity of stormwater runoff after dormant spray application of diazinon and esfenvalerate (Asana) in a French prune orchard, Glenn county, California, USA. 
  • Variation in toxicity of copper pyrithione among populations and families of the barnacle, Balanus amphitrite. 
  • Viability of cancer cells exposed to pulsed electric fields: the role of pulse charge. 
  • Yersinia pestis kills Caenorhabditis elegans by a biofilm-independent process that involves novel virulence factors. 
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  Keywords of People

  • Charles, Hal Cecil, Adjunct Associate Professor in the Department of Radiology, Radiology