Leucine

• 

  Subject Areas on Research

  • 3-Hydroxyisovalerylcarnitine in 3-methylcrotonyl-CoA carboxylase deficiency. 
  • A Delphi-based consensus clinical practice protocol for the diagnosis and management of 3-methylcrotonyl CoA carboxylase deficiency. 
  • A STE12 homolog is required for mating but dispensable for filamentation in candida lusitaniae. 
  • A human mononuclear leukocyte chemotactic factor: characterization, specificity and kinetics of production by homologous leukocytes. 
  • A kinetic study of embryonic cell adhesion. 
  • A novel beta-globin mutation, beta Durham-NC [beta 114 Leu-->Pro], produces a dominant thalassemia-like phenotype. 
  • A single amino acid change in the para sodium channel protein is associated with knockdown-resistance (kdr) to pyrethroid insecticides in German cockroach. 
  • A surface of Escherichia coli sigma 70 required for promoter function and antitermination by phage lambda Q protein. 
  • Age attenuates leucine oxidation after eccentric exercise. 
  • Aged-related physiological studies comparing Candida albicans chlamydospores to yeasts. 
  • Altered light responses of single rod photoreceptors in transgenic pigs expressing P347L or P347S rhodopsin. 
  • An analysis of type-C retrovirus polypeptides and their associations in the virion. 
  • Antagonists of the system L neutral amino acid transporter (LAT) promote endothelial adhesivity of human red blood cells. 
  • Anti-AIDS agents 49. Synthesis, anti-HIV, and anti-fusion activities of IC9564 analogues based on betulinic acid. 
  • Branched-Chain Aminotransferases Control TORC1 Signaling in Saccharomyces cerevisiae. 
  • Cell aggregation: properties of cell surface factors from five species of sponge. 
  • Characterization of a chemotactic and cytotoxic proteinase from human skin. 
  • Cocaine acutely inhibits DNA synthesis in developing rat brain regions: evidence for direct actions. 
  • Cocaine exacerbates hypoxia-induced cell damage in the developing brain: effects on ornithine decarboxylase activity and protein synthesis. 
  • Conformation-assisted inhibition of protein-tyrosine phosphatase-1B elicits inhibitor selectivity over T-cell protein-tyrosine phosphatase. 
  • Consumption of whole eggs promotes greater stimulation of postexercise muscle protein synthesis than consumption of isonitrogenous amounts of egg whites in young men. 
  • Conversion of Tyr361 beta to Leu in mammalian protein farnesyltransferase impairs product release but not substrate recognition. 
  • Course and laminar origin of the tectoparabigeminal pathway. 
  • Decreased protein synthesis of transforming lymphocytes from aged humans: relationship to impaired mitogenesis with age. 
  • E-cadherin polarity is determined by a multifunction motif mediating lateral membrane retention through ankyrin-G and apical-lateral transcytosis through clathrin. 
  • Early intracellular events in the replication of bacteriophage T4 deoxyribonucleic acid. VI. Newly synthesized proteins in the T4 protein-deoxyribonucleic acid complex. 
  • Effect of FSH on protein biosynthesis in testes of the immature rat. 
  • Effect of cyclic adenosine 3',5'-monophosphate on the incorporation of 3H-leucine into polypeptides by beef thyroid polysomes in vitro. 
  • Effect of growth conditions on the activity of ornithine decarboxylase in cultured hepatoma cells. I. Effect of amino acid supply. 
  • Effect of inhibitors of proteolytic enzymes on the growth of normal and polyoma transformed BHK cells. 
  • Effect of pH and anions on functional properties of hemoglobin from Lemur fulvus fulvus. 
  • Effects of a novel Mac-1 inhibitor, NPC 15669, on hemostatic parameters during preconditioned myocardial infarction. 
  • Effects of fatty acid composition on the sensitivity of membrane functions to ethanol in Escherichia coli. 
  • Efferent projections of the main and the accessory olfactory bulb in the tree shrew (Tupaia glis). 
  • Eight Weeks of Treatment With Glecaprevir/Pibrentasvir Is Safe and Efficacious in an Integrated Analysis of Treatment-Naïve Patients With Hepatitis C Virus Infection. 
  • Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function. 
  • Endogenous catabolism is the major source of toxic metabolites in isovaleric acidemia. 
  • Enhanced protein breakdown after eccentric exercise in young and older men. 
  • Exploring steric constraints on protein mutations using MAGE/PROBE. 
  • Fetal dexamethasone exposure sensitizes neonatal rat brain to hypoxia: effects on protein and DNA synthesis. 
  • Functional consequences of truncating amino acid side chains located at a calmodulin-peptide interface. 
  • Glecaprevir and pibrentasvir yield high response rates in patients with HCV genotype 1-6 without cirrhosis. 
  • Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomerase. 
  • Huntington's-chorea fibroblasts. Cellular protein glycosylation. 
  • Hydrophobic residues Phe751 and Leu753 are essential for STAT5 transcriptional activity. 
  • Identification of amino acid residues in the insect sodium channel critical for pyrethroid binding. 
  • Increases in ribosomal RNA within the denervated neuropil of the dentate gyrus during reinnervation: evaluation by in situ hybridization using DNA probes complementary to ribosomal RNA. 
  • Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness. 
  • Inhibition of protein synthesis also inhibits synthesis of lipid-linked oligosaccharides. 
  • Inhibitory proteins in the Newcastle disease virus-induced suppression of cell protein synthesis. 
  • Intrachromosomal gene conversion in yeast. 
  • L-leucine partially rescues translational and developmental defects associated with zebrafish models of Cornelia de Lange syndrome. 
  • Laminar origin of ipsilateral tectopontine pathways. 
  • Leucine metabolism during fasting and exercise. 
  • Leucine periodicity of U2 small nuclear ribonucleoprotein particle (snRNP) A' protein is implicated in snRNP assembly via protein-protein interactions. 
  • Living related versus deceased donor liver transplantation for maple syrup urine disease. 
  • Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds. 
  • Mac-1 inhibitor affects certain hemostatic parameters during myocardial stunning in swine. 
  • Mitotic recombination within the centromere of a yeast chromosome. 
  • Modulating protein structure with fluorous amino acids: increased stability and native-like structure conferred on a 4-helix bundle protein by hexafluoroleucine. 
  • Mutational analysis of the leucine zipper-like motif of the human immunodeficiency virus type 1 envelope transmembrane glycoprotein. 
  • Mutations in Saccharomyces cerevisiae which confer resistance to several amino acid analogs. 
  • NLR surveillance of pathogen interference with hormone receptors induces immunity. 
  • New Treatment Options for Hepatitis C Virus Infection in End-Stage Kidney Disease: To Treat or Not to Treat. 
  • Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region. 
  • Pathogenic mutations in neurofibromin identifies a leucine-rich domain regulating glioma cell invasiveness. 
  • Peroxide detoxification affecting the production of immunoglobulin by mouse myeloma tumor cells in vitro. 
  • Pharmaconutrition review: physiological mechanisms. 
  • Plasma fibronectin during myocardial ischemia-reperfusion: effects of magnesium, diltiazem, and a novel Mac-1 inhibitor. 
  • Podocan, a novel small leucine-rich repeat protein expressed in the sclerotic glomerular lesion of experimental HIV-associated nephropathy. 
  • Polypeptides of mammalian oncornaviruses. III. Localization of p 15 and reactivity with natural antibody. 
  • Pretreatment with an inhibitor of mac-1 alters regional and systemic platelet function during ischemia-reperfusion in swine. 
  • Production of chemotactic factor and lymphotoxin by human leukocytes stimulated with Herpes simplex virus. 
  • Protein turnover and energy metabolism of elderly women fed a low-protein diet. 
  • Rapid degradation of puromycyl peptides in hepatoma cells and reticulocytes. 
  • Rapid diagnosis of homocystinuria and other hypermethioninemias from newborns' blood spots by tandem mass spectrometry. 
  • Rapid diagnosis of maple syrup urine disease in blood spots from newborns by tandem mass spectrometry. 
  • Recombination between genes located on nonhomologous chromosomes in Saccharomyces cerevisiae. 
  • Role of AP-1 complex in angiotensin II-mediated transforming growth factor-beta expression and growth of smooth muscle cells: using decoy approach against AP-1 binding site. 
  • SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion. 
  • Salmonella typhimurium leucine-rich repeat proteins are targeted to the SPI1 and SPI2 type III secretion systems. 
  • Secondary structure of a leucine zipper determined by nuclear magnetic resonance spectroscopy. 
  • Serial changes of soluble endothelin-1 levels during myocardial ischaemia-reperfusion. Effects of magnesium, diltiazem and a novel MAC-1 inhibitor. 
  • Serial changes of the plasma prostanoids during myocardial ischemia-reperfusion in swine. Effects of magnesium, diltiazem, and a novel Mac-1 inhibitor. 
  • Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila. 
  • Simplified monitoring for hepatitis C virus treatment with glecaprevir plus pibrentasvir, a randomised non-inferiority trial. 
  • Small leucine rich repeat proteoglycans (SLRPs) in the human sclera: identification of abundant levels of PRELP. 
  • Statins inhibit toll-like receptor 4-mediated lipopolysaccharide signaling and cytokine expression. 
  • Stimulation of cartilage macromolecule synthesis by adenosine 3',5'-monophosphate. 
  • Stimulation of cell-free polypeptide synthesis by a protein fraction extracted from chick oviduct polyribosomes. 
  • Stimulation of neutrophil oxidative metabolism by chemotactic peptides: influence of calcium ion concentration and cytochalasin B and comparison with stimulation by phorbol myristate acetate. 
  • Structural basis for HIV-1 neutralization by a gp41 fusion intermediate-directed antibody. 
  • Synthesis and Preliminary Evaluation of 5-[18F]fluoroleucine. 
  • Synthesis and secretion of gamma-globulin by lymph node cells. VI. Characteristics of the structure of immunoglobulin A and its pattern of secretion by appendix cell suspensions. 
  • The Haemophilus influenzae hFbpABC Fe3+ transporter: analysis of the membrane permease and development of a gallium-based screen for mutants. 
  • The Skeletal Muscle Anabolic Response to Plant- versus Animal-Based Protein Consumption. 
  • The carboxyl-terminal amino acids render pro-human LC3B migration similar to lipidated LC3B in SDS-PAGE. 
  • The essential role of L-glutamine in lymphocyte differentiation in vitro. 
  • The laminar origin and distribution of the crossed tectoreticular pathways. 
  • The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells. 
  • The structure of PurR mutant L54M shows an alternative route to DNA kinking. 
  • Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission. 
  • Transport interactions of cystine and dibasic amino acids in isolated rat renal tubules. 
  • Transport rather than diffusion-dependent route for nitric oxide gas activity in alveolar epithelium. 
  • Transposed LEU2 gene of Saccharomyces cerevisiae is regulated normally. 
  • Transpulmonary flux of S-nitrosothiols and pulmonary vasodilation during nitric oxide inhalation: role of transport. 
  • Triiodothyronine stimulation of in vitro growth and maturation of embryonic chick cartilage. 
  • he effect of inhibitors of protein synthesis on the level of ribosomal subunits in ascites cells. 
  • β-Cell-specific ablation of sirtuin 4 does not affect nutrient-stimulated insulin secretion in mice. 
• 

  Keywords of People

  • Luftig, Micah Alan, Professor of Molecular Genetics and Microbiology, Cell Biology