Lymphocyte Culture Test, Mixed

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  Subject Areas on Research

  • A comparative study of the generation of dendritic cells from mobilized peripheral blood progenitor cells of patients undergoing high-dose chemotherapy. 
  • A synthetic random basic copolymer with promiscuous binding to class II major histocompatibility complex molecules inhibits T-cell proliferative responses to major and minor histocompatibility antigens in vitro and confers the capacity to prevent murine graft-versus-host disease in vivo. 
  • Accelerated thymic maturation and autoreactive T cells in bronchopulmonary dysplasia. 
  • Activation of human B lymphocytes. V. Kinetics and mechanisms of suppression of plaque-forming cell responses by concanavalin A-generated suppressor cells. 
  • Active specific immunotherapy of Dukes B2 and C colorectal carcinoma: comparison of two doses of the vaccine. 
  • Administration of a CD31-derived peptide delays the onset and significantly increases survival from lethal graft-versus-host disease. 
  • Amplification of suppressor inducer pathway with monoclonal antibody, anti-2H4, identifying a novel epitope of the common leukocyte antigen/T200 antigen. 
  • Angiotensin II: an immune costimulator? 
  • Anti-TCRβ mAb induces long-term allograft survival by reducing antigen-reactive T cells and sparing regulatory T cells. 
  • Bone marrow and thymus transplantation in ataxia-telangiectasia. 
  • CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells. 
  • CD4+ T-cell and monocyte interdependence during discordant xenoimmune responses. 
  • Characterization of human chemotactic lymphokine production induced by mitogens and mixed leukocyte reactions using a new microassay. 
  • Differentiation of human T lymphocytes. I. Acquisition of a novel human cell surface protein (p80) during normal intrathymic T cell maturation. 
  • Donor specific bone marrow cells suppress lymphocyte reactivity to donor antigens and differentially modulate TH1 and TH2 cytokine gene expression in the responder cell population. 
  • Donor-specific bone marrow cells suppress lymphocyte reactivity to donor antigens and differentially modulate TH1 and TH2 cytokine gene expression in the responder cell population. 
  • Early-outgrowth of endothelial progenitor cells can function as antigen-presenting cells. 
  • Effect of immunosuppressants on T-cell subsets observed in vivo using carboxy-fluorescein diacetate succinimidyl ester labeling. 
  • Effects of murine cytomegalovirus infection on the immune response to a tumor allograft. 
  • Factors associated with graft rejection after HLA-identical marrow transplantation for aplastic anaemia. 
  • Generation of dendritic cells in vitro from peripheral blood mononuclear cells with granulocyte-macrophage-colony-stimulating factor, interleukin-4, and tumor necrosis factor-alpha for use in cancer immunotherapy. 
  • Graft hyporeactivity induced by donor-derived dendritic cell progenitors. 
  • Graft hyporeactivity induced by immature donor-derived dendritic cells. 
  • Graft-versus-host disease prevention by rapamycin: cellular mechanisms. 
  • High-frequency alloreactive T cells augment effector function of low-frequency CD8+ T-cell responses under CD28/CD154 blockade. 
  • Histocompatibility testing and mixed lymphocyte culture responses in chimpanzee families. 
  • Human antiporcine mixed lymphocyte reaction. 
  • Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. 
  • Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells. 
  • Human retrovirus-related synthetic peptides inhibit T lymphocyte proliferation. 
  • IDEC-131 (anti-CD154), sirolimus and donor-specific transfusion facilitate operational tolerance in non-human primates. 
  • Immune status assay (ISA): a noninvasive procedure for studying allograft rejection. 
  • Immunologic studies on T and B lymphocytes in chimpanzees: effects of thymectomy and irradiation. 
  • In vitro analysis of the human antiporcine T-cell repertoire. 
  • Inability of gestational hormones to account for the inhibitory effects of pregnancy plasmas on lymphocyte responses in vitro. 
  • Inability of memory T cells to induce graft-versus-host disease is a result of an abortive alloresponse. 
  • Induction of autologous mixed lymphocyte culture responses by myelin basic protein-reactive T cell clones. 
  • Induction of tolerance to solubilized rat histocompatibility antigens. 
  • Induction therapy with monoclonal antibodies specific for CD80 and CD86 delays the onset of acute renal allograft rejection in non-human primates. 
  • Inhibition of T cell costimulation by VCAM-1 prevents murine graft-versus-host disease across minor histocompatibility barriers. 
  • Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins. 
  • K12/SECTM1, an interferon-γ regulated molecule, synergizes with CD28 to costimulate human T cell proliferation. 
  • Lack of generation of killer cells in the mixed lymphocyte reaction between mitogen-stimulated and unstimulated autologous lymphocytes. 
  • Lack of specificity of cyclosporine immunoassays. Results of a College of American Pathologists Study. 
  • Lymphocyte activation markers may predict the presence of donor specific alloreactivity in pediatric living related liver transplant recipients. 
  • Mechanisms of tolerance to parental parathyroid tissue when combined with human allogeneic thymus transplantation. 
  • Mixed leukocyte culture reactivity and graft-versus-host disease in HLA-identical marrow transplantation for leukemia. 
  • Mixed lymphocyte reactions and skin graft survival in an HL-A recombinant family. 
  • Mixed lymphocyte responses in a four-generation C2 deficiency family. 
  • Mixed-lymphocyte-culture responses in chimpanzee families. 
  • Modified responses to recipient and donor B cells by genetically donor T cells from human haploidentical bone marrow chimeras. 
  • Modulation of alloreactivity in transplant recipients by phenotypic manipulation of donor endothelium. 
  • Monoclonal antibody OKT3-induced T cell proliferation: differential role of HLA class II determinants expressed by T cells and monocytes. 
  • Monotherapy with the novel human anti-CD154 monoclonal antibody ABI793 in rhesus monkey renal transplantation model. 
  • Nondepleting anti-CD40-based therapy prolongs allograft survival in nonhuman primates. 
  • PG27, an extract of Tripterygium wilfordii hook f, induces antigen-specific tolerance in bone marrow transplantation in mice. 
  • Patterns of de novo allo B cells and antibody formation in chronic cardiac allograft rejection after alemtuzumab treatment. 
  • Phenotypic and functional maturation of dendritic cells mediated by heparan sulfate. 
  • Phenotypic characterization of human cytolytic T lymphocytes in mixed lymphocyte culture. 
  • Primary vascularization of the graft determines the immunodominance of murine minor H antigens during organ transplantation. 
  • Proinflammatory actions of thromboxane receptors to enhance cellular immune responses. 
  • Rabbit anti-human leukocyte polyclonal antibody inhibits xenogeneic cell-mediated immune responses. 
  • Receptors for prostaglandin E(2) that regulate cellular immune responses in the mouse. 
  • Recipient Myd88 Deficiency Promotes Spontaneous Resolution of Kidney Allograft Rejection. 
  • Renal transplantation between histocompatible donor-recipient pairs. 
  • Requirement of cognate CD4+ T-cell recognition for the regulation of allospecific CTL by human CD4+ CD127- CD25+ FOXP3+ cells generated in MLR. 
  • Role of complement activation in obliterative bronchiolitis post-lung transplantation. 
  • Split tolerance induced by immunotoxin in a rhesus kidney allograft model. 
  • Studies investigating pretransplant donor-specific blood transfusion, rapamycin, and the CD154-specific antibody IDEC-131 in a nonhuman primate model of skin allotransplantation. 
  • Suppressor function of T lymphocytes in the acquired immunodeficiency syndrome as assessed by allogeneic mixed lymphocyte culture. 
  • Tat-functionalized near-infrared emissive polymersomes for dendritic cell labeling. 
  • The human antiporcine cellular repertoire. In vitro studies of acquired and innate cellular responsiveness. 
  • The immunogenetics of the major histocompatibility chromosomal region in man. 
  • The induction of tolerance of renal allografts by adoptive transfer in miniature swine. 
  • The role of IL-13 in the generation of dendritic cells in vitro. 
  • Three populations of cells with dendritic morphology exist in peripheral blood, only one of which is infectable with human immunodeficiency virus type 1. 
  • Thrombospondin-1 derived from APCs regulates their capacity for allosensitization. 
  • Total lymphoid irradiation for cardiac xenotransplantation in nonhuman primates. 
  • Transplantation in miniature swine. I. Fixation of the major histocompatibility complex. 
  • Transplantation in miniature swine. II. In vitro parameters of histocompatibility in MSLA homozygous minipigs. 
  • Transplantation in miniature swine. VI. Factors influencing survival of renal allografts. 
  • Variables affecting the T cell receptor V beta repertoire heterogeneity of T cells infiltrating human renal allografts. 
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  Keywords of People

  • Cianciolo, George James, Associate Professor Emeritus of Pathology, Pathology