Leukocytes, Mononuclear

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  Subject Areas on Research

  • 4-1BB Agonism Averts TIL Exhaustion and Licenses PD-1 Blockade in Glioblastoma and Other Intracranial Cancers. 
  • 4-hydroperoxycyclophosphamide--purged peripheral blood stem cells for autologous transplantation in patients with acute myeloid leukemia. 
  • A cell culture system that enhances mononuclear cell IgE synthesis induced by recombinant human interleukin-4. 
  • A cytogenetic comparison of the responses of mouse and human peripheral blood lymphocytes to 60Co gamma radiation. 
  • A gene expression signature for recent onset rheumatoid arthritis in peripheral blood mononuclear cells. 
  • A pilot study of high-intensity interval training in older adults with treatment naïve chronic lymphocytic leukemia. 
  • A role for fractalkine and its receptor (CX3CR1) in cardiac allograft rejection. 
  • A synthetic peptide homologous to the envelope proteins of retroviruses inhibits monocyte-mediated killing by inactivating interleukin 1. 
  • A template for physical resilience research in older adults: Methods of the PRIME-KNEE study. 
  • A whole-genome analysis of premature termination codons. 
  • ADAM metallopeptidase domain 17 (ADAM17) is naturally processed through major histocompatibility complex (MHC) class I molecules and is a potential immunotherapeutic target in breast, ovarian and prostate cancers. 
  • Absence of recoverable infectious virus and unique immune responses in an asymptomatic HIV+ long-term survivor. 
  • Activated T lymphocytes regulate hyaluronan binding to monocyte CD44 via production of IL-2 and IFN-gamma. 
  • Adaptation of an R5 Simian-Human Immunodeficiency Virus Encoding an HIV Clade A Envelope with or without Ablation of Adaptive Host Immunity: Differential Selection of Viral Mutants. 
  • Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget's Disease of Bone. 
  • Aging and dietary modulation of elastase and interleukin-1 beta secretion. 
  • Allogeneic leukocytes but not therapeutic blood elements induce reactivation and dissemination of latent human immunodeficiency virus type 1 infection: implications for transfusion support of infected patients. 
  • Alpha 2-macroglobulin binds CpG oligodeoxynucleotides and enhances their immunostimulatory properties by a receptor-dependent mechanism. 
  • An in vitro analogue of immune dysfunction with altered immunoglobulin production in the aged. 
  • Analysis of clones derived from human CD7+CD4-CD8-CD3- thymocytes. 
  • Analysis of muscle creatine kinase regulatory elements in recombinant adenoviral vectors. 
  • Analysis of the immune responses in chimpanzees infected with HIV type 1 isolates. 
  • Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce beta-chemokines. 
  • Antibody-mediated neutralization of primary isolates of human immunodeficiency virus type 1 in peripheral blood mononuclear cells is not affected by the initial activation state of the cells. 
  • Application of area scaling analysis to identify natural killer cell and monocyte involvement in the GranToxiLux antibody dependent cell-mediated cytotoxicity assay. 
  • Autologous bone marrow mononuclear cell therapy is safe and promotes amputation-free survival in patients with critical limb ischemia. 
  • Autophagy is redundant for the host defense against systemic Candida albicans infections. 
  • Behçet's disease patients present high levels of deglycosylated anti-lipoteichoic acid IgG and high IL-8 production after lipoteichoic acid stimulation. 
  • Blood mononuclear cell nitric oxide production and plasma cytokine levels in healthy gabonese children with prior mild or severe malaria. 
  • Blood-sample processing for the study of age-dependent gene expression in peripheral blood mononuclear cells. 
  • Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface. 
  • Broadly Neutralizing Antibodies Display Potential for Prevention of HIV-1 Infection of Mucosal Tissue Superior to That of Nonneutralizing Antibodies. 
  • CD161 contributes to prenatal immune suppression of IFNγ-producing PLZF+ T cells. 
  • CD2-mediated IL-12-dependent signals render human gamma delta-T cells resistant to mitogen-induced apoptosis, permitting the large-scale ex vivo expansion of functionally distinct lymphocytes: implications for the development of adoptive immunotherapy strategies. 
  • Cell mediated immune responses following revaccination with an influenza A/H5N1 vaccine. 
  • Cell surface expression of major histocompatibility class I antigens is modulated by P-glycoprotein transporter. 
  • Cell-cell interactions and bronchoconstrictor eicosanoid reduction with inhaled carbon monoxide and resolvin D1. 
  • Characterization of a recombinant adenovirus vector encoding heat-inducible feline interleukin-12 for use in hyperthermia-induced gene-therapy. 
  • Characterization of a thymus-tropic HIV-1 isolate from a rapid progressor: role of the envelope. 
  • Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection. 
  • Chlamydia trachomatis Infection of Endocervical Epithelial Cells Enhances Early HIV Transmission Events. 
  • Circular viral DNA and anomalous junction sequence in PBMC of HIV-infected individuals with no detectable plasma HIV RNA. 
  • Circulating CD34+ cell counts are predictive of CD34+ peripheral blood progenitor cell yields. 
  • Circulating progenitor cells can be reliably identified on the basis of aldehyde dehydrogenase activity. 
  • Comparable Antigenicity and Immunogenicity of Oligomeric Forms of a Novel, Acute HIV-1 Subtype C gp145 Envelope for Use in Preclinical and Clinical Vaccine Research. 
  • Comparison of blood collected in acid-citrate-dextrose and EDTA for use in human immunodeficiency virus peripheral blood mononuclear cell cultures. 
  • Comparison of human immunodeficiency virus antigens as stimulants for lymphocyte proliferation assays. 
  • Comparison of systemic and mucosal immunization with helper-dependent adenoviruses for vaccination against mucosal challenge with SHIV. 
  • Complement factor H protects tumor cell-derived exosomes from complement-dependent lysis and phagocytosis. 
  • Complex determinants in human immunodeficiency virus type 1 envelope gp120 mediate CXCR4-dependent infection of macrophages. 
  • Comprehensive epitope mapping of the Epstein-Barr virus latent membrane protein-2 in normal, non tumor-bearing individuals. 
  • Continuous DC-CIK infusions restore CD8+ cellular immunity, physical activity and improve clinical efficacy in advanced cancer patients unresponsive to conventional treatments. 
  • Corneal endothelial cell abnormalities in an early stage of the iridocorneal endothelial syndrome. 
  • Coupling Hematoma Evacuation with Immune Profiling for Analysis of Neuroinflammation After Primary Intracerebral Hemorrhage: A Pilot Study. 
  • Critical assessment of automated flow cytometry data analysis techniques. 
  • Cross-reactive human immunodeficiency virus type 1-neutralizing human monoclonal antibody that recognizes a novel conformational epitope on gp41 and lacks reactivity against self-antigens. 
  • Cytokine gene polymorphisms and the outcome of invasive candidiasis: a prospective cohort study. 
  • Cytomegalovirus (CMV) shedding is highly correlated with markers of immunosuppression in CMV-seropositive women. 
  • DNA damage in peripheral blood mononuclear cells correlates with response to biochemotherapy in melanoma. 
  • Decreased DNA methyltransferase 3A and 3B mRNA expression in peripheral blood mononuclear cells and increased plasma SAH concentration in adult patients with idiopathic thrombocytopenic purpura. 
  • Decreased circulating macrophage migration inhibitory factor (MIF) protein and blood mononuclear cell MIF transcripts in children with Plasmodium falciparum malaria. 
  • Degenerate TCR recognition and dual DR2 restriction of autoreactive T cells: implications for the initiation of the autoimmune response in multiple sclerosis. 
  • Derivation and Characterization of a CD4-Independent, Non-CD4-Tropic Simian Immunodeficiency Virus. 
  • Development and use of SIV-based Integrase defective lentiviral vector for immunization. 
  • Development of a contemporary globally diverse HIV viral panel by the EQAPOL program. 
  • Diagnosis of partial body radiation exposure in mice using peripheral blood gene expression profiles. 
  • Dietary omega-3 fatty acid intake impacts peripheral blood DNA methylation -anti-inflammatory effects and individual variability in a pilot study. 
  • Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion. 
  • Differential expression of alternatively spliced pX mRNAs in HTLV-I-infected cell lines. 
  • Differential gene expression of interleukin-1 receptor associated kinase-1 and interleukin-1 receptor associated kinase-M in peripheral blood mononuclear cells of young and aged rats following preconditioning with endotoxin. 
  • Differential inhibition of human immunodeficiency virus type 1 in peripheral blood mononuclear cells and TZM-bl cells by endotoxin-mediated chemokine and gamma interferon production. 
  • Downregulation of the AU-rich RNA-binding protein ZFP36 in chronic HBV patients: implications for anti-inflammatory therapy. 
  • Dual tropism of HIV-1 envelopes derived from renal tubular epithelial cells of patients with HIV-associated nephropathy. 
  • Dysregulated transcriptional responses to SARS-CoV-2 in the periphery. 
  • EPC mobilization after erythropoietin treatment in acute ST-elevation myocardial infarction: the REVEAL EPC substudy. 
  • Early hematopoiesis inhibition under chronic radiation exposure in humans. 
  • Effect of dietary fat saturation and cholesterol on low density lipoprotein degradation by mononuclear cells of Cebus monkeys. 
  • Effect of plasmid DNA vaccine design and in vivo electroporation on the resulting vaccine-specific immune responses in rhesus macaques. 
  • Effects of cellular activation on anti-HIV-1 restriction factor expression profile in primary cells. 
  • Efficacy and safety of live attenuated persistent and rapidly cleared Mycobacterium tuberculosis vaccine candidates in non-human primates. 
  • Efficacy of the pharmacologic chaperone migalastat in a subset of male patients with the classic phenotype of Fabry disease and migalastat-amenable variants: data from the phase 3 randomized, multicenter, double-blind clinical trial and extension study. 
  • Elevated nitric oxide production in children with malarial anemia: hemozoin-induced nitric oxide synthase type 2 transcripts and nitric oxide in blood mononuclear cells. 
  • Endothelial Stromal PD-L1 (Programmed Death Ligand 1) Modulates CD8+ T-Cell Infiltration After Heart Transplantation. 
  • Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells. 
  • Enrichment of human bone marrow mononuclear phagocytes and characterization of macrophage subpopulations by immunoenzymatic double staining. 
  • Enumerating antigen-specific T-cell responses in peripheral blood: a comparison of peptide MHC Tetramer, ELISpot, and intracellular cytokine analysis. 
  • Envelope glycoprotein binding to the integrin α4β7 is not a general property of most HIV-1 strains. 
  • Epigenetic regulation of CD8(+) T-lymphocyte mediated suppression of HIV-1 replication. 
  • Epstein-Barr virus DNA load in chronic lymphocytic leukemia is an independent predictor of clinical course and survival. 
  • Establishing lymphoblastoid cell lines from frozen blood of extremely old individuals. 
  • Establishment and maintenance of a PBMC repository for functional cellular studies in support of clinical vaccine trials. 
  • Establishment of normative ranges of the healthy human immune system with comprehensive polychromatic flow cytometry profiling. 
  • Evaluating neutralizing antibodies against HIV, SIV, and SHIV in luciferase reporter gene assays. 
  • Evaluation of peritoneal fluid following intestinal resection and anastomosis in horses. 
  • Evaluation of the spectra Optia® mononuclear cell collection procedure in multiple myeloma patients. 
  • Evidence that antibody-mediated neutralization of human immunodeficiency virus type 1 by sera from infected individuals is independent of coreceptor usage. 
  • Evolutionarily conserved epitopes on human immunodeficiency virus type 1 (HIV-1) and feline immunodeficiency virus reverse transcriptases detected by HIV-1-infected subjects. 
  • Expression levels of TLRs involved in viral recognition in PBMCs from HIV-1-infected patients failing antiretroviral therapy. 
  • Extra-placental expression of vascular endothelial growth factor receptor-1, (Flt-1) and soluble Flt-1 (sFlt-1), by peripheral blood mononuclear cells (PBMCs) in normotensive and preeclamptic pregnant women. 
  • Extracellular Loops of the Treponema pallidum FadL Orthologs TP0856 and TP0858 Elicit IgG Antibodies and IgG+-Specific B-Cells in the Rabbit Model of Experimental Syphilis. 
  • Flavivirus serocomplex cross-reactive immunity is protective by activating heterologous memory CD4 T cells. 
  • Flow cytometry analysis of adenosine deaminase (ADA) expression: a simple and reliable tool for the assessment of ADA-deficient patients before and after gene therapy. 
  • Full hematopoietic engraftment after allogeneic bone marrow transplantation without cytoreduction in a child with severe combined immunodeficiency. 
  • Functional Homology for Antibody-Dependent Phagocytosis Across Humans and Rhesus Macaques. 
  • Functional analysis of antigen-specific T lymphocytes by serial measurement of gene expression in peripheral blood mononuclear cells and tumor specimens. 
  • Gene expression profile in circulating mononuclear cells after exposure to ultrafine carbon particles. 
  • Gene expression signatures that predict radiation exposure in mice and humans. 
  • Gene-expression profiling of the response of peripheral blood mononuclear cells and melanoma metastases to systemic IL-2 administration. 
  • Generation of dendritic cells in vitro from peripheral blood mononuclear cells with granulocyte-macrophage-colony-stimulating factor, interleukin-4, and tumor necrosis factor-alpha for use in cancer immunotherapy. 
  • Genetic variation in the dectin-1/CARD9 recognition pathway and susceptibility to candidemia. 
  • Genetically and epidemiologically related "non-syncytium-inducing" isolates of HIV-1 display heterogeneous growth patterns in macrophages. 
  • Glutamine attenuates tumor necrosis factor-alpha release and enhances heat shock protein 72 in human peripheral blood mononuclear cells. 
  • Glycoengineering HIV-1 Env creates 'supercharged' and 'hybrid' glycans to increase neutralizing antibody potency, breadth and saturation. 
  • Gnidimacrin, a Potent Anti-HIV Diterpene, Can Eliminate Latent HIV-1 Ex Vivo by Activation of Protein Kinase C β. 
  • HIV quasispecies and resampling. 
  • HIV-1 extrachromosomal 2-LTR circular DNA is long-lived in human macrophages. 
  • Hematopoietic cell transplantation with cord blood for cure of HIV infections. 
  • Hepatic enrichment and activation of myeloid dendritic cells during chronic hepatitis C virus infection. 
  • High-resolution deep sequencing reveals biodiversity, population structure, and persistence of HIV-1 quasispecies within host ecosystems. 
  • Highly complex neutralization determinants on a monophyletic lineage of newly transmitted subtype C HIV-1 Env clones from India. 
  • Highly conserved gene expression profiles in humans with allergic rhinitis altered by immunotherapy. 
  • Human IFN-gamma production is inhibited by a synthetic peptide homologous to retroviral envelope protein. 
  • Human dendritic cells, pulsed with either melanoma tumor cell lysates or the gp100 peptide(280-288), induce pairs of T-cell cultures with similar phenotype and lytic activity. 
  • Human peripheral mononuclear cells do not show proinflammatory patterns of cytokine transcription in early trauma: a preliminary report. 
  • Human umbilical cord blood monocytes, but not adult blood monocytes, rescue brain cells from hypoxic-ischemic injury: Mechanistic and therapeutic implications. 
  • IDEC-131 (anti-CD154), sirolimus and donor-specific transfusion facilitate operational tolerance in non-human primates. 
  • IL-11 antagonist suppresses Th17 cell-mediated neuroinflammation and demyelination in a mouse model of relapsing-remitting multiple sclerosis. 
  • Identification and visualization of multidimensional antigen-specific T-cell populations in polychromatic cytometry data. 
  • Identification of HIV-1 genitourinary tract compartmentalization by analyzing the env gene sequences in urine. 
  • Identification of the ligand-binding domains of CD22, a member of the immunoglobulin superfamily that uniquely binds a sialic acid-dependent ligand. 
  • Immune Activation in Early-Stage Non-Small Cell Lung Cancer Patients Receiving Neoadjuvant Chemotherapy Plus Ipilimumab. 
  • Immunomagnetic selection of purified monocyte and lymphocyte populations from peripheral blood mononuclear cells following cryopreservation. 
  • Impact of HIV-1 backbone on neutralization sensitivity: neutralization profiles of heterologous envelope glycoproteins expressed in native subtype C and CRF01_AE backbone. 
  • Impact of cryopreservation on tetramer, cytokine flow cytometry, and ELISPOT. 
  • In Vitro Differentiation of Tumor-Associated Macrophages from Monocyte Precursors with Modified Melanoma-Conditioned Medium. 
  • Increased expression of anti-apoptosis genes in peripheral blood cells from patients with paroxysmal nocturnal hemoglobinuria. 
  • Increased expression of blood mononuclear cell nitric oxide synthase type 2 in rheumatoid arthritis patients. 
  • Increased mtDNA levels without change in mitochondrial enzymes in peripheral blood mononuclear cells of infants born to HIV-infected mothers on antiretroviral therapy. 
  • Induction of CD4(+) and CD8(+) T-cell responses to the human stromal antigen, fibroblast activation protein: implication for cancer immunotherapy. 
  • Inflammation and Metabolism of Influenza-Stimulated Peripheral Blood Mononuclear Cells From Adults With Obesity Following Bariatric Surgery. 
  • Inflammatory Protein Profiles in Plasma of Candidaemia Patients and the Contribution of Host Genetics to Their Variability. 
  • Influence of proinflammatory cytokines on Actinobacillus actinomycetemcomitans specific IgG responses. 
  • Inhibition of interleukin-2 and interferon-gamma by an HIV-1 Nef-encoded synthetic peptide. 
  • Innate immune signatures to a partially-efficacious HIV vaccine predict correlates of HIV-1 infection risk. 
  • Integrating factor analysis and a transgenic mouse model to reveal a peripheral blood predictor of breast tumors. 
  • Integrative analyses reveal signaling pathways underlying familial breast cancer susceptibility. 
  • Interleukin 12 at the site of disease in tuberculosis. 
  • Intracellular Tenofovir and Emtricitabine Concentrations in Younger and Older Women with HIV Receiving Tenofovir Disoproxil Fumarate/Emtricitabine. 
  • Intradermal HIV-1 DNA Immunization Using Needle-Free Zetajet Injection Followed by HIV-Modified Vaccinia Virus Ankara Vaccination Is Safe and Immunogenic in Mozambican Young Adults: A Phase I Randomized Controlled Trial. 
  • Intranasal delivery of an adjuvanted modified live porcine reproductive and respiratory syndrome virus vaccine reduces ROS production. 
  • Inverse relationship of plasma prostaglandin E2 and blood mononuclear cell cyclooxygenase-2 with disease severity in children with Plasmodium falciparum malaria. 
  • Isolation and generation of human dendritic cells. 
  • Isolation and generation of human dendritic cells. 
  • Isolation and transplantation of autologous circulating endothelial cells into denuded vessels and prosthetic grafts: implications for cell-based vascular therapy. 
  • Isolation of monoclonal antibodies with predetermined conformational epitope specificity. 
  • Kinetics of cytokine expression in melanoma metastases classifies immune responsiveness. 
  • Kinetics of human immunodeficiency virus type 1 (HIV-1) DNA and RNA synthesis during primary HIV-1 infection. 
  • Leukopak PBMC sample processing for preparing quality control material to support proficiency testing programs. 
  • Linkage of the CCR5 Delta 32 mutation with a functional polymorphism of CD45RA. 
  • Long-term killing of natural killer-resistant target cells by interferon-alpha-, interferon-gamma-, and interleukin-2-activated natural killer cells. 
  • Long-term vaccine protection from AIDS and clearance of viral DNA following SHIV89.6P challenge. 
  • Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual. 
  • Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines. 
  • Mandelic acid condensation polymer: novel candidate microbicide for prevention of human immunodeficiency virus and herpes simplex virus entry. 
  • Marginal vitamin B-6 deficiency decreases plasma (n-3) and (n-6) PUFA concentrations in healthy men and women. 
  • Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection. 
  • Measurement of cytokine release at the single cell level using the ELISPOT assay. 
  • Measurement of direct and indirect forms of anti-HIV-1 ADCC: implications for other retroviral disease. 
  • Metastable tolerance to rhesus monkey renal transplants is correlated with allograft TGF-beta 1+CD4+ T regulatory cell infiltrates. 
  • Mitigation of variation observed in a peripheral blood mononuclear cell (PBMC) based HIV-1 neutralization assay by donor cell pooling. 
  • Mobilization of dendritic cells in cancer patients treated with granulocyte colony-stimulating factor and chemotherapy. 
  • Molecular characterization of circulating plasma cells in patients with active systemic lupus erythematosus. 
  • Monoclonal Antibodies, Derived from Humans Vaccinated with the RV144 HIV Vaccine Containing the HVEM Binding Domain of Herpes Simplex Virus (HSV) Glycoprotein D, Neutralize HSV Infection, Mediate Antibody-Dependent Cellular Cytotoxicity, and Protect Mice from Ocular Challenge with HSV-1. 
  • Mononuclear cells from patients with the hyper-IgE syndrome produce little IgE when they are stimulated with recombinant human interleukin-4. 
  • Mucosal and systemic anti-HIV responses in rhesus macaques following combinations of intranasal and parenteral immunizations. 
  • Mucosal and systemic immune activation is present in human immunodeficiency virus-exposed seronegative women. 
  • Mucosal-associated invariant T cell responses differ by sex in COVID-19. 
  • Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies. 
  • Murine female reproductive tract intraepithelial lymphocytes display selection characteristics distinct from both peripheral and other mucosal T cells. 
  • Mycobacterium tuberculosis whole cell lysate enhances proliferation of CD8 positive lymphocytes and nitric oxide secretion in the lungs of live porcine respiratory and reproductive syndrome virus vaccinated pigs. 
  • Myeloid-derived suppressors cells (MDSC) correlate with clinicopathologic factors and pathologic complete response (pCR) in patients with urothelial carcinoma (UC) undergoing cystectomy. 
  • Natural infection of a household pet red-capped mangabey (Cercocebus torquatus torquatus) with a new simian immunodeficiency virus. 
  • Natural killer cell infection and inactivation in vitro by the human immunodeficiency virus. 
  • Nef expressed from human immunodeficiency virus type 1 extrachromosomal DNA downregulates CD4 on primary CD4+ T lymphocytes: implications for integrase inhibitors. 
  • Neutralizing Activity of Broadly Neutralizing Anti-HIV-1 Antibodies against Clade B Clinical Isolates Produced in Peripheral Blood Mononuclear Cells. 
  • Neutralizing and infection-enhancing antibody responses to human immunodeficiency virus type 1 in long-term nonprogressors. 
  • Neutralizing antibody responses to human immunodeficiency virus type 1 in primary infection and long-term-nonprogressive infection. 
  • Neutrophil-Related Gene Expression and Low-Density Granulocytes Associated With Disease Activity and Response to Treatment in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. 
  • Nitric oxide production and mononuclear cell nitric oxide synthase activity in malaria-tolerant Papuan adults. 
  • Nitric oxide synthase 2 and cyclooxygenase 2 interactions in inflammation. 
  • Non-redundant roles for interleukin-1 alpha and interleukin-1 beta in regulating human IgG2. 
  • Novel Strategy To Adapt Simian-Human Immunodeficiency Virus E1 Carrying env from an RV144 Volunteer to Rhesus Macaques: Coreceptor Switch and Final Recovery of a Pathogenic Virus with Exclusive R5 Tropism. 
  • Novel mechanisms of immune modulation of natalizumab in multiple sclerosis patients. 
  • OMIP-006: phenotypic subset analysis of human T regulatory cells via polychromatic flow cytometry. 
  • Optimization of storage and shipment of cryopreserved peripheral blood mononuclear cells from HIV-infected and uninfected individuals for ELISPOT assays. 
  • Oral administration of an Enoki mushroom protein FVE activates innate and adaptive immunity and induces anti-tumor activity against murine hepatocellular carcinoma. 
  • Oxidative DNA base damage in MCF-10A breast epithelial cells at clinically achievable concentrations of doxorubicin. 
  • Oxidative DNA base modifications in peripheral blood mononuclear cells of patients treated with high-dose infusional doxorubicin. 
  • PF4-HIT antibody (KKO) complexes activate broad innate immune and inflammatory responses. 
  • Packed red blood cells suppress T-cell proliferation through a process involving cell-cell contact. 
  • Partial resistance to infection by R5X4 primary HIV type 1 isolates in an exposed-uninfected individual homozygous for CCR5 32-base pair deletion. 
  • Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge. 
  • Performance of serum-supplemented and serum-free media in IFNgamma Elispot Assays for human T cells. 
  • Peripheral Blood Mononuclear Cells Demonstrate Mitochondrial Damage Clearance During Sepsis. 
  • Peripheral blood dendritic cells, but not monocyte-derived dendritic cells, can augment human NK cell function. 
  • Peripheral blood mononuclear cells from patients with bullous pemphigoid have an increased frequency of response to synthetic peptides encoded by BPAG1. 
  • Phase 2 study of the g209-2M melanoma peptide vaccine and low-dose interleukin-2 in advanced melanoma: Cancer and Leukemia Group B 509901. 
  • Phase I clinical and plasma and cellular pharmacological study of topotecan without and with granulocyte colony-stimulating factor. 
  • Phase I study of bevacizumab, everolimus, and panobinostat (LBH-589) in advanced solid tumors. 
  • Phase I study of immunization with dendritic cells modified with fowlpox encoding carcinoembryonic antigen and costimulatory molecules. 
  • Phylodynamics of HIV-1 in lymphoid and non-lymphoid tissues reveals a central role for the thymus in emergence of CXCR4-using quasispecies. 
  • Plasma and Intracellular Concentrations in HIV-Infected Patients Requiring Hemodialysis Dosed With Tenofovir Disoproxil Fumarate and Emtricitabine. 
  • Plasma interleukin-12 in malaria-tolerant papua new guineans: inverse correlation with Plasmodium falciparum parasitemia and peripheral blood mononuclear cell nitric oxide synthase activity. 
  • Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein transferase type-I. 
  • Preoperative mobilization of circulating dendritic cells by Flt3 ligand administration to patients with metastatic colon cancer. 
  • Preparation of peptide-loaded dendritic cells for cancer immunotherapy. 
  • Preservation of motor function by inhibition of CD8+ virus peptide-specific T cells in Theiler's virus infection. 
  • Progesterone-induced immunosuppression is not mediated through the progesterone receptor. 
  • Quality assurance program for peripheral blood mononuclear cell cryopreservation. 
  • Quiescent phenotype of tumor-specific CD8+ T cells following immunization. 
  • RCA2: a scalable supervised clustering algorithm that reduces batch effects in scRNA-seq data. 
  • Race-related differences in antibody responses to the inactivated influenza vaccine are linked to distinct pre-vaccination gene expression profiles in blood. 
  • Rapid and Efficient Generation of Transgene-Free iPSC from a Small Volume of Cryopreserved Blood. 
  • Rapid freezing of whole blood or buffy coat samples for polymerase chain reaction and cell culture analysis: application to detection of human immunodeficiency virus in blood donor and recipient repositories. The Transfusion Safety Study Group. 
  • Recent advances in the characterization of HIV-1 neutralization assays for standardized evaluation of the antibody response to infection and vaccination. 
  • Recombinant human IL-4 induces IgE and IgG synthesis by normal and atopic donor mononuclear cells. Similar dose response, time course, requirement for T cells, and effect of pokeweed mitogen. 
  • Reduced peripheral PGE2 biosynthesis in Plasmodium falciparum malaria occurs through hemozoin-induced suppression of blood mononuclear cell cyclooxygenase-2 gene expression via an interleukin-10-independent mechanism. 
  • Reduction of NOS2 overexpression in rheumatoid arthritis patients treated with anti-tumor necrosis factor alpha monoclonal antibody (cA2). 
  • Regulation of leukocyte adhesion molecule-1 (TQ1, Leu-8) expression and shedding by normal and malignant cells. 
  • Results of an ELISPOT proficiency panel conducted in 11 laboratories participating in international human immunodeficiency virus type 1 vaccine trials. 
  • Rhesus immune responses to SIV Gag expressed by recombinant BCG vectors are independent from pre-existing mycobacterial immunity. 
  • Role of TGF-beta1 in renal parenchymal scarring following childhood urinary tract infection. 
  • Safety and Immunogenicity of a Randomized Phase 1 Prime-Boost Trial With ALVAC-HIV (vCP205) and Oligomeric Glycoprotein 160 From HIV-1 Strains MN and LAI-2 Adjuvanted in Alum or Polyphosphazene. 
  • Safety and immunogenicity of Env 2-3, a human immunodeficiency virus type 1 candidate vaccine, in combination with a novel adjuvant, MTP-PE/MF59. NIAID AIDS Vaccine Evaluation Group. 
  • Safety and immunogenicity of cytotoxic T-lymphocyte poly-epitope, DNA plasmid (EP HIV-1090) vaccine in healthy, human immunodeficiency virus type 1 (HIV-1)-uninfected adults. 
  • Saturation of 2',2'-difluorodeoxycytidine 5'-triphosphate accumulation by mononuclear cells during a phase I trial of gemcitabine. 
  • Screening the human exome: a comparison of whole genome and whole transcriptome sequencing. 
  • Season and size of urban particulate matter differentially affect cytotoxicity and human immune responses to Mycobacterium tuberculosis. 
  • Secretory leukocyte protease inhibitor blocks infectivity of primary monocytes and mononuclear cells with both monocytotropic and lymphocytotropic strains of human immunodeficiency virus type I. 
  • Selection of insulinoma cell lines with resistance to interleukin-1beta- and gamma-interferon-induced cytotoxicity. 
  • Selective targeting of human alloresponsive CD8+ effector memory T cells based on CD2 expression. 
  • Setting objective thresholds for rare event detection in flow cytometry. 
  • Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22, MIP-1alpha, CCL27, IP-10, CCR4, CCR5, CXCR3, PD1, PDL2, IL-3, IFN-beta, TIM1, and TLR2 but low antigen-specific cellular responses. 
  • Shared signatures of social stress and aging in peripheral blood mononuclear cell gene expression profiles. 
  • Sickle red cells induce adhesion of lymphocytes and monocytes to endothelium. 
  • Silencing the porcine iGb3s gene does not affect Galα3Gal levels or measures of anticipated pig-to-human and pig-to-primate acute rejection. 
  • Sinus histiocytosis with massive lymphadenopathy. Case report and review of a multisystemic disease with cutaneous infiltrates. 
  • Social affiliation predicts mitochondrial DNA copy number in female rhesus macaques. 
  • Social status alters chromatin accessibility and the gene regulatory response to glucocorticoid stimulation in rhesus macaques. 
  • Studies in subjects with long-term nonprogressive human immunodeficiency virus infection. 
  • Substance P and calcitonin gene-related peptide increase IL-1 beta, IL-6 and TNF alpha secretion from human peripheral blood mononuclear cells. 
  • Suppression of prostaglandin E2 by malaria parasite products and antipyretics promotes overproduction of tumor necrosis factor-alpha: association with the pathogenesis of childhood malarial anemia. 
  • T cell repertoire development in humans with SCID after nonablative allogeneic marrow transplantation. 
  • T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates. 
  • The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen. 
  • The Center for HIV/AIDS Vaccine Immunology (CHAVI) multi-site quality assurance program for cryopreserved human peripheral blood mononuclear cells. 
  • The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections. 
  • The Regulation of Proresolving Lipid Mediator Profiles in Baboon Pneumonia by Inhaled Carbon Monoxide. 
  • The antisense transcriptomes of human cells. 
  • The discriminative capacity of soluble Toll-like receptor (sTLR)2 and sTLR4 in inflammatory diseases. 
  • The exon A (C77G) mutation is a common cause of abnormal CD45 splicing in humans. 
  • The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy. 
  • The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia. 
  • The relationship between hostility and beta-adrenergic receptor physiology in health young males. 
  • The relative activity of "function sparing" HIV-1 entry inhibitors on viral entry and CCR5 internalization: is allosteric functional selectivity a valuable therapeutic property? 
  • The role of IL-13 in the generation of dendritic cells in vitro. 
  • The role of natural killer (NK) cells and NK cell receptor polymorphisms in the assessment of HIV-1 neutralization. 
  • Therapeutic white blood cell and platelet depletions using the spectra OPTIA system continuous mononuclear cell protocol. 
  • Thymopoiesis in HIV-infected adults after highly active antiretroviral therapy. 
  • Tissue-specific genetic control of splicing: implications for the study of complex traits. 
  • Transcriptional network predicts viral set point during acute HIV-1 infection. 
  • Transcriptomic analysis of peripheral blood mononuclear cells in rapid progressors in early HIV infection identifies a signature closely correlated with disease progression. 
  • Transcriptomic changes in the nasal epithelium associated with diesel engine exhaust exposure. 
  • Translational randomized phase II trial of cabozantinib in combination with nivolumab in advanced, recurrent, or metastatic endometrial cancer. 
  • Transplantation of thymus tissue in complete DiGeorge syndrome. 
  • Treatment of infants with complete DiGeorge anomaly. 
  • Tumor necrosis factor-alpha-induced lung injury and its modulation by synthetic polynucleotide: a physiologic-morphometric analysis. 
  • Unbiased immune profiling reveals a natural killer cell-peripheral nerve axis in fibromyalgia. 
  • Variability in bioreactivity linked to changes in size and zeta potential of diesel exhaust particles in human immune cells. 
  • Videos of Sipuleucel-T Programmed T Cells Lysing Cells That Express Prostate Cancer Target Antigens. 
  • Viral genetic evolution in macaques infected with molecularly cloned simian immunodeficiency virus correlates with the extent of persistent viremia. 
  • ZPLD1 gene is disrupted in a patient with balanced translocation that exhibits cerebral cavernous malformations. 
  • α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration. 
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  Keywords of People

  • Buckley, Rebecca Hatcher, James Buren Sidbury Distinguished Professor Emeritus of Pediatrics, in the School of Medicine, Pediatrics, Allergy and Immunology
  • Ferrari, Guido, Professor in Surgery, Molecular Genetics and Microbiology
  • Uronis, Hope Elizabeth, Associate Professor of Medicine, Medicine, Medical Oncology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Integrative Immunobiology
  • Zafar, Syed Yousuf, Adjunct Professor in the Department of Medicine, Duke Science & Society
  • Zennadi, Rahima, Associate Professor in Medicine, Pathology