Leukotriene B4

• 

  Subject Areas on Research

  • 12(S)-hydroxy-5,8,10,14-eicosatetraenoic acid is a more potent neutrophil chemoattractant than the 12(R) epimer in the rat cornea. 
  • 5-Lipoxygenase products modulate the activity of the 85-kDa phospholipase A2 in human neutrophils. 
  • Airway inflammation and responsiveness in prostaglandin H synthase-deficient mice exposed to bacterial lipopolysaccharide. 
  • Allergic lung responses are increased in prostaglandin H synthase-deficient mice. 
  • An enzyme that inactivates the inflammatory mediator leukotriene b4 restricts mycobacterial infection. 
  • BMS-229724 is a tight-binding inhibitor of cytosolic phospholipase A2 that acts at the lipid/water interface and possesses anti-inflammatory activity in skin inflammation models. 
  • Calcium influx stimulates a second pathway for sustained diacylglycerol production in leukocytes activated by chemoattractants. 
  • Chemoattractant receptors activate distinct pathways for chemotaxis and secretion. Role of G-protein usage. 
  • Chemoattractant receptors on phagocytic cells. 
  • Deficiency of 5-lipoxygenase accelerates renal allograft rejection in mice. 
  • Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. 
  • Effects of repetitive motion on human fibroblasts. 
  • Enhanced renal leukotriene production in murine lupus: role of lipoxygenase metabolites. 
  • Fish oil feeding modulates leukotriene production in murine lupus nephritis. 
  • Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN). 
  • Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections. 
  • Increased acute inflammation, leukotriene B4-induced chemotaxis, and signaling in mice deficient for G protein-coupled receptor kinase 6. 
  • Leukotriene B4 mediates inflammation via TRPV1 in duct obstruction-induced pancreatitis in rats. 
  • Leukotriene B4 stimulates the release of arachidonate in human neutrophils via the action of cytosolic phospholipase A2. 
  • Leukotrienes in renal transplant rejection in rats. Distinct roles for leukotriene B4 and peptidoleukotrienes in the pathogenesis of allograft injury. 
  • Mechanical stress and nitric oxide influence leukotriene production in cartilage. 
  • Molecular mechanisms of leukocyte activation by chemoattractants. 
  • Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles. 
  • Role of mast cell leukotrienes in neutrophil recruitment and bacterial clearance in infectious peritonitis. 
  • Sensitizing effects of leukotriene B4 on intradental primary afferents. 
  • Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816. 
  • The Regulation of Proresolving Lipid Mediator Profiles in Baboon Pneumonia by Inhaled Carbon Monoxide. 
  • The role of leukotriene B4 in Clostridium difficile toxin A-induced ileitis in rats. 
  • Thiopyrano[2,3,4-cd]indoles as 5-lipoxygenase inhibitors: synthesis, biological profile, and resolution of 2-[2-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5 -dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic acid.