-
Subject Areas on Research
-
12(S)-hydroxy-5,8,10,14-eicosatetraenoic acid is a more potent neutrophil chemoattractant than the 12(R) epimer in the rat cornea.
-
5-Lipoxygenase products modulate the activity of the 85-kDa phospholipase A2 in human neutrophils.
-
Airway inflammation and responsiveness in prostaglandin H synthase-deficient mice exposed to bacterial lipopolysaccharide.
-
Allergic lung responses are increased in prostaglandin H synthase-deficient mice.
-
An enzyme that inactivates the inflammatory mediator leukotriene b4 restricts mycobacterial infection.
-
Calcium influx stimulates a second pathway for sustained diacylglycerol production in leukocytes activated by chemoattractants.
-
Chemoattractant receptors activate distinct pathways for chemotaxis and secretion. Role of G-protein usage.
-
Chemoattractant receptors on phagocytic cells.
-
Deficiency of 5-lipoxygenase accelerates renal allograft rejection in mice.
-
Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome.
-
Effects of repetitive motion on human fibroblasts.
-
Enhanced renal leukotriene production in murine lupus: role of lipoxygenase metabolites.
-
Fish oil feeding modulates leukotriene production in murine lupus nephritis.
-
Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN).
-
Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections.
-
Increased acute inflammation, leukotriene B4-induced chemotaxis, and signaling in mice deficient for G protein-coupled receptor kinase 6.
-
Leukotriene B4 mediates inflammation via TRPV1 in duct obstruction-induced pancreatitis in rats.
-
Leukotrienes in renal transplant rejection in rats. Distinct roles for leukotriene B4 and peptidoleukotrienes in the pathogenesis of allograft injury.
-
Mechanical stress and nitric oxide influence leukotriene production in cartilage.
-
Molecular mechanisms of leukocyte activation by chemoattractants.
-
Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles.
-
Role of mast cell leukotrienes in neutrophil recruitment and bacterial clearance in infectious peritonitis.
-
Role of surface complexed iron in oxidant generation and lung inflammation induced by silicates.
-
Sensitizing effects of leukotriene B4 on intradental primary afferents.
-
Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816.
-
The Regulation of Proresolving Lipid Mediator Profiles in Baboon Pneumonia by Inhaled Carbon Monoxide.
-
Thiopyrano[2,3,4-cd]indoles as 5-lipoxygenase inhibitors: synthesis, biological profile, and resolution of 2-[2-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5 -dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic acid.