Ligands

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  Subject Areas on Research

  • 'Biasing' the parathyroid hormone receptor: a novel anabolic approach to increasing bone mass? 
  • 16 alpha-substituted analogs of the antiprogestin RU486 induce a unique conformation in the human progesterone receptor resulting in mixed agonist activity. 
  • 17beta-Nitro-5alpha-androstan-3alpha-ol and its 3beta-methyl derivative: neurosteroid analogs with potent anticonvulsant and anxiolytic activities. 
  • 2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: synthesis, affinity for nicotinic acetylcholine receptors, and molecular modeling. 
  • 2-[18F]F-A-85380: PET imaging of brain nicotinic acetylcholine receptors and whole body distribution in humans. 
  • 2-[18F]F-A-85380: a PET radioligand for alpha4beta2 nicotinic acetylcholine receptors. 
  • 31P NMR probes of chemical dynamics: paramagnetic relaxation enhancement of the (1)H and (31)P NMR resonances of methyl phosphite and methylethyl phosphate anions by selected metal complexes. 
  • 5-substituted derivatives of 6-halogeno-3-((2-(S)-azetidinyl)methoxy)pyridine and 6-halogeno-3-((2-(S)-pyrrolidinyl)methoxy)pyridine with low picomolar affinity for alpha4beta2 nicotinic acetylcholine receptor and wide range of lipophilicity: potential probes for imaging with positron emission tomography. 
  • A 3D numerical study of the effect of channel height on leukocyte deformation and adhesion in parallel-plate flow chambers. 
  • A New, Second Generation Trithiol Bifunctional Chelate for 72,77As: Trithiol(b)-(Ser)2-RM2. 
  • A Scalable, Multiplexed Assay for Decoding GPCR-Ligand Interactions with RNA Sequencing. 
  • A colorimetric gold nanoparticle sensor to interrogate biomolecular interactions in real time on a surface. 
  • A crystal structure of a dimer of the antibiotic ramoplanin illustrates membrane positioning and a potential Lipid II docking interface. 
  • A desensitized state of the beta adrenergic receptor not associated with high-affinity agonist occupancy. 
  • A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. 
  • A dual-ligand approach for enhancing targeting selectivity of therapeutic nanocarriers. 
  • A family of hierarchically self-assembling linear-dendritic hybrid polymers for highly efficient targeted gene delivery. 
  • A functional tethered ligand thrombin receptor is present on human hematopoietic progenitor cells. 
  • A futile metabolic cycle activated in adipocytes by antidiabetic agents. 
  • A general and efficient cantilever functionalization technique for AFM molecular recognition studies. 
  • A general mass spectrometry-based assay for the quantitation of protein-ligand binding interactions in solution. 
  • A leukocyte lipid up-regulates the avidity of lymphocyte function-associated antigen-1. 
  • A marriage of enhancement: fibrinolysis and conjunctive therapy. 
  • A multidisciplinary approach to probing enthalpy-entropy compensation and the interfacial mobility model. 
  • A new irreversibly inhibited form of xanthine oxidase from ethylisonitrile. 
  • A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors. 
  • A novel murine protein with no effect on iron homoeostasis is homologous with transferrin and is the putative inhibitor of carbonic anhydrase. 
  • A perspective essay on the use of Ga³⁺ as a proxy for Fe³⁺ in bioinorganic model studies and its successful use for therapeutic purposes. 
  • A photolabile ligand for light-activated release of caged copper. 
  • A quantitative analysis of beta-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding data. 
  • A role for the epidermal growth factor-like domain of P-selectin in ligand recognition and cell adhesion. 
  • A single acidic residue can guide binding site selection but does not govern QacR cationic-drug affinity. 
  • A single heteromeric receptor complex is sufficient to mediate biological effects of transforming growth factor-beta ligands. 
  • A study of the binding of thiamine diphosphate and thiochrome diphosphate to the pyruvate dehydrogenase multienzyme complex. 
  • A thermodynamic ligand binding study of the third PDZ domain (PDZ3) from the mammalian neuronal protein PSD-95. 
  • Abl tyrosine kinase regulates endocytosis of the epidermal growth factor receptor. 
  • Accumulation of hedgehog-responsive progenitors parallels alcoholic liver disease severity in mice and humans. 
  • Accuracy and precision of a new H/D exchange- and mass spectrometry-based technique for measuring the thermodynamic properties of protein-peptide complexes. 
  • Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP2. 
  • Activation of Human Peroxisome Proliferator-Activated Nuclear Receptors (PPARγ1) by Semi-Volatile Compounds (SVOCs) and Chemical Mixtures in Indoor Dust. 
  • Activation of orphan receptor-mediated transcription by Ca(2+)/calmodulin-dependent protein kinase IV. 
  • Activation of the NLRP3 inflammasome by intracellular poly I:C. 
  • Activation of the aryl-hydrocarbon receptor inhibits invasive and metastatic features of human breast cancer cells and promotes breast cancer cell differentiation. 
  • Activation of toll-like receptor 4 is necessary for trauma hemorrhagic shock-induced gut injury and polymorphonuclear neutrophil priming. 
  • Active Targeting of Cancer Cells by Nanobody Decorated Polypeptide Micelle with Bio-orthogonally Conjugated Drug. 
  • Active learning for computational chemogenomics. 
  • Adenosine nucleotides and the regulation of GRP94-client protein interactions. 
  • Adenylate cyclase-coupled beta-adrenergic receptors: structure and mechanisms of activation and desensitization. 
  • Adhesion mediated by bonds in series. 
  • Adrenergic receptors. 
  • Affinity chromatography of adrenergic receptors and binding proteins. 
  • Agonist interactions with alpha-adrenergic receptors. 
  • Agonists of G-Protein-Coupled Odorant Receptors Are Predicted from Chemical Features. 
  • Algorithm selection for protein-ligand docking: strategies and analysis on ACE. 
  • Allelic and locus heterogeneity in inherited venous malformations. 
  • Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library. 
  • Allosteric actuation of inverse phase transition of a stimulus-responsive fusion polypeptide by ligand binding. 
  • Allosteric cooperation in a de novo-designed two-domain protein. 
  • Allosteric intermediates indicate R2 is the liganded hemoglobin end state. 
  • Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. 
  • Alpha-adrenergic receptor subtypes: quantitative assessment by ligand binding. 
  • Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors. 
  • An L-selectin ligand distinct from P-selectin glycoprotein ligand-1 is expressed on endothelial cells and promotes neutrophil rolling in inflammation. 
  • An assessment of the effects of shell cross-linked nanoparticle size, core composition, and surface PEGylation on in vivo biodistribution. 
  • An enthalpic basis of additivity in biphenyl hydroxamic acid ligands for stromelysin-1. 
  • An equilibrium model of endothelial cell adhesion via integrin-dependent and integrin-independent ligands. 
  • An imaging-based approach to identify ligands for olfactory receptors. 
  • An inhibitory region of the DNA-binding domain of thyroid hormone receptor blocks hormone-dependent transactivation. 
  • Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells. 
  • Analysis of allosteric signal transduction mechanisms in an engineered fluorescent maltose biosensor. 
  • Analysis of ligand binding specificity of receptor chimeras. 
  • Analysis of the effect of three different allosteric ligands on oxygen binding by hemocyanin of the shrimp, Penaeus setiferus. 
  • Androgen receptor-cofactor interactions as targets for new drug discovery. 
  • Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity. 
  • Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations. 
  • Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR. 
  • Anion modulation of the negative Bohr effect of haemoglobin from a primitive amphibian. 
  • Anthrabenzoxocinones from Streptomyces sp. as liver X receptor ligands and antibacterial agents. 
  • Antibodies against the voltage-dependent anion channel (VDAC) and its protective ligand hexokinase-I in children with autism. 
  • Antidote control of aptamer therapeutics: the road to a safer class of drug agents. 
  • Antigen delivery by alpha(2)-macroglobulin enhances the cytotoxic T lymphocyte response. 
  • Antitumor activity of epidermal growth factor receptor-related protein is mediated by inactivation of ErbB receptors and nuclear factor-kappaB in pancreatic cancer. 
  • Application of random peptide phage display to the study of nuclear hormone receptors. 
  • Aptamers as Reversible Sorting Ligands for Preparation of Cells in Their Native State. 
  • Aromatic hydrocarbon receptor polymorphism: development of new methods to correlate genotype with phenotype. 
  • Arrestin interaction with E3 ubiquitin ligases and deubiquitinases: functional and therapeutic implications. 
  • Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling. 
  • Ascaris haemoglobin is a nitric oxide-activated 'deoxygenase'. 
  • Assembling OX40 aptamers on a molecular scaffold to create a receptor-activating aptamer. 
  • Assignment of transforming growth factor beta1 and beta3 and a third new ligand to the type I receptor ALK-1. 
  • Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands. 
  • Automated design of ligands to polypharmacological profiles. 
  • Automated identification of protein-ligand interaction features using Inductive Logic Programming: a hexose binding case study. 
  • Autoradiographic localization of benzomorphan binding sites in rat brain. 
  • Autoreceptor regulation of glutamate and aspartate release from slices of the hippocampal CA1 area. 
  • Avidity and Cell Uptake of Integrin-Targeting Polypeptide Micelles is Strongly Shape-Dependent. 
  • BCR and Endosomal TLR Signals Synergize to Increase AID Expression and Establish Central B Cell Tolerance. 
  • BMP ligands act redundantly to pattern the dorsal telencephalic midline. 
  • BMP signaling and cellular dynamics during regeneration of airway epithelium from basal progenitors. 
  • Bacterially expressed HIV-1 gp120 outer-domain fragment immunogens with improved stability and affinity for CD4-binding site neutralizing antibodies. 
  • Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity. 
  • Beta-adrenergic receptors: evidence for negative cooperativity. 
  • Beta-arrestin-biased ligands at seven-transmembrane receptors. 
  • Beta-arrestins: multifunctional cellular mediators. 
  • Beta-catenin signaling pathway is crucial for bone morphogenetic protein 2 to induce new bone formation. 
  • Biased Allosteric Modulators: New Frontiers in GPCR Drug Discovery. 
  • Biased G Protein-Coupled Receptor Signaling: Changing the Paradigm of Drug Discovery. 
  • Biased agonism as a mechanism for differential signaling by chemokine receptors. 
  • Biased agonism at chemokine receptors. 
  • Biased agonists of the chemokine receptor CXCR3 differentially control chemotaxis and inflammation. 
  • Biased signalling: from simple switches to allosteric microprocessors. 
  • Binding and signaling of surface-immobilized reagentless fluorescent biosensors derived from periplasmic binding proteins. 
  • Binding site on human immunoglobulin G for the affinity ligand HWRGWV. 
  • Biochemical characterization of the adrenergic receptors: affinity labeling, purification, and reconstitution studies. 
  • Biochemistry of soluble guanylate cyclase. 
  • Bivalent peptides as PDZ domain ligands. 
  • Blocking the initiation of coagulation by RNA aptamers to factor VIIa. 
  • Bombesin inhibits alveolarization and promotes pulmonary fibrosis in newborn mice. 
  • Bridged peptide macrocycles as ligands for PDZ domain proteins. 
  • Butyl isocyanide as a probe of the activation mechanism of soluble guanylate cyclase. Investigating the role of non-heme nitric oxide. 
  • C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1. 
  • CCL3L1 and HIV/AIDS susceptibility. 
  • CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation. 
  • CD22 ligand binding regulates normal and malignant B lymphocyte survival in vivo. 
  • CD22 regulates B lymphocyte function in vivo through both ligand-dependent and ligand-independent mechanisms. 
  • CD22 serves as a receptor for soluble IgM. 
  • CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling. 
  • CD22-Binding Synthetic Sialosides Regulate B Lymphocyte Proliferation Through CD22 Ligand-Dependent and Independent Pathways, and Enhance Antibody Production in Mice. 
  • CD28 ligation induces tyrosine phosphorylation of Pyk2 but not Fak in Jurkat T cells. 
  • CD44--a molecule involved in leukocyte adherence and T-cell activation. 
  • CD6-ligand interactions: a paradigm for SRCR domain function? 
  • CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin. 
  • CNG-modulin: a novel Ca-dependent modulator of ligand sensitivity in cone photoreceptor cGMP-gated ion channels. 
  • COI1 is a critical component of a receptor for jasmonate and the bacterial virulence factor coronatine. 
  • CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival. 
  • CXCR3-mediated T-cell chemotaxis involves ZAP-70 and is regulated by signalling through the T-cell receptor. 
  • CYP7B1: one cytochrome P450, two human genetic diseases, and multiple physiological functions. 
  • Calmodulin structure refined at 1.7 A resolution. 
  • Calorimetric analysis of the binding of lectins with overlapping carbohydrate-binding ligand specificities. 
  • Can prenylcysteines be exploited as ligands for mammalian multidrug-resistance transporters? 
  • Candidate genes on murine chromosome 8 are associated with susceptibility to Staphylococcus aureus infection in mice and are involved with Staphylococcus aureus septicemia in humans. 
  • Cannabinoid CB(1) receptor expression, activation and detection of endogenous ligand in trabecular meshwork and ciliary process tissues. 
  • Capitalizing on the complexities of estrogen receptor pharmacology in the quest for the perfect SERM. 
  • Carbon chain shape selectivity by the mouse olfactory receptor OR-I7. 
  • Casein kinase Iepsilon plays a functional role in the transforming growth factor-beta signaling pathway. 
  • Cell adhesion peptides alter smooth muscle cell adhesion, proliferation, migration, and matrix protein synthesis on modified surfaces and in polymer scaffolds. 
  • Cell cycle-dependent expression of thyroid hormone receptor-beta is a mechanism for variable hormone sensitivity. 
  • Cell- and heparin-binding domains of the hexabrachion arm identified by tenascin expression proteins. 
  • Cell-surface co-receptors: emerging roles in signaling and human disease. 
  • Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers. 
  • Cellular mechanisms of wingless/Wnt signal transduction. 
  • Characterization of a CD6 ligand(s) expressed on human- and murine-derived cell lines and murine lymphoid tissues. 
  • Characterization of the aqueous iron(III) chelation chemistry of a potential Trojan Horse antimicrobial agent: chelate structure, stability and pH dependent speciation. 
  • Characterization of the ionizable groups interacting with anionic allosteric effectors of human hemoglobin. 
  • Characterizing the peroxisome proliferator-activated receptor (PPARγ) ligand binding potential of several major flame retardants, their metabolites, and chemical mixtures in house dust. 
  • Chemical aspects of siderophore mediated iron transport. 
  • Chemical modification of alpha 2-adrenoceptors. Possible role for tyrosine in the ligand binding site. 
  • Chemically Orthogonal Protein Ligation Domains for Independent Control of Hydrogel Modification with Adhesive Ligands and Growth Factors. 
  • Chemically induced proximity in biology and medicine. 
  • Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selective α4β2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats. 
  • Chemokine ligand and receptor expression in the pregnant uterus: reciprocal patterns in complementary cell subsets suggest functional roles. 
  • Chemokine mediated control of dendritic cell migration and function. 
  • Chemokine-adjuvanted electroporated DNA vaccine induces substantial protection from simian immunodeficiency virus vaginal challenge. 
  • Clearance and binding of native and defucosylated lactoferrin. 
  • Clinical results in cachexia therapeutics. 
  • Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. 
  • Co-assembling peptides as defined matrices for endothelial cells. 
  • Coarse-grained modeling of allosteric regulation in protein receptors. 
  • Combination of a novel heat shock protein 90-targeted photodynamic therapy with PD-1/PD-L1 blockade induces potent systemic antitumor efficacy and abscopal effect against breast cancers. 
  • Combinatorial depletions of G-protein coupled receptor kinases in immune cells identify pleiotropic and cell type-specific functions. 
  • Comment on "Identification of Novel G Protein-Coupled Receptor 143 Ligands as Pharmacologic Tools for Investigating X-Linked Ocular Albinism". 
  • Community guidelines for GPCR ligand bias: IUPHAR review 32. 
  • Comparison of specificity of agonist and antagonist radioligand binding to beta adrenergic receptors. 
  • Computational design of a biologically active enzyme. 
  • Computational design of receptor and sensor proteins with novel functions. 
  • Computational design of receptors for an organophosphate surrogate of the nerve agent soman. 
  • Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor. 
  • Conformational Basis of G Protein-Coupled Receptor Signaling Versatility. 
  • Conformational analysis, pharmacophore identification, and comparative molecular field analysis of ligands for the neuromodulatory sigma 3 receptor. 
  • Conformational kinetics reveals affinities of protein conformational states. 
  • Conformational selection or induced fit: a flux description of reaction mechanism. 
  • Constitutively active retinoid receptors exhibit interfamily and intrafamily promoter specificity. 
  • Constructing RNA dynamical ensembles by combining MD and motionally decoupled NMR RDCs: new insights into RNA dynamics and adaptive ligand recognition. 
  • Construction of a fluorescent biosensor family. 
  • Construction of new ligand binding sites in proteins of known structure. II. Grafting of a buried transition metal binding site into Escherichia coli thioredoxin. 
  • Control of protein-ligand recognition using a stimuli-responsive polymer. 
  • Conversion of a maltose receptor into a zinc biosensor by computational design. 
  • Coordination chemistry of siderophores: thermodynamics and kinetics of iron chelation and release. 
  • Correlation of expression of bombesin-like peptides and receptors with growth inhibition by an anti-bombesin antibody in small-cell lung cancer cell lines. 
  • Costimulation blockade: towards clinical application. 
  • Coupling coherence distinguishes structure sensitivity in protein electron transfer. 
  • Covalent labeling of the beta-adrenergic ligand-binding site with para-(bromoacetamidyl)benzylcarazolol. A highly potent beta-adrenergic affinity label. 
  • Covalent labelling of ligand binding sites of human placental S-adenosylhomocysteine hydrolase with 8-azido derivatives of adenosine and cyclic AMP. 
  • Crystal structure of deoxygenated Limulus polyphemus subunit II hemocyanin at 2.18 A resolution: clues for a mechanism for allosteric regulation. 
  • Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution. 
  • Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity. 
  • Crystal structures of QacR-diamidine complexes reveal additional multidrug-binding modes and a novel mechanism of drug charge neutralization. 
  • Crystal structures of adenine phosphoribosyltransferase from Leishmania donovani. 
  • Crystallization of succinylated concanavalin A bound to a synthetic bivalent ligand and preliminary structural analysis. 
  • Current View of Ligand and Lipid Recognition by the Menthol Receptor TRPM8. 
  • Cutting edge: trimolecular interaction of TCR with MHC class II and bacterial superantigen shows a similar affinity to MHC:peptide ligands. 
  • Cyclophilin B escorts the hepatitis C virus RNA polymerase: a viral achilles heel? 
  • Cytochemistry of sex steroid receptors: a critique. 
  • De novo design of a hyperstable non-natural protein-ligand complex with sub-Å accuracy. 
  • DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe. 
  • Decoupled LIGHT-SABRE variants allow hyperpolarization of asymmetric SABRE systems at an arbitrary field. 
  • Definition of distinct compartments in polarized Madin-Darby canine kidney (MDCK) cells for membrane-volume sorting, polarized sorting and apical recycling. 
  • Definition of the molecular basis for estrogen receptor-related receptor-alpha-cofactor interactions. 
  • Degradation of the Met tyrosine kinase receptor by the ubiquitin-proteasome pathway. 
  • Delivery of antisense oligonucleotides using HPMA polymer: synthesis of A thiol polymer and its conjugation to water-soluble molecules. 
  • Dendritic cell CD83: a therapeutic target or innocent bystander? 
  • Deorphaning the Macromolecular Targets of the Natural Anticancer Compound Doliculide. 
  • Describing Complex Structure-Function Relationships in Biomolecules at Equilibrium. 
  • Design and stereoselective preparation of a new class of chiral olefin metathesis catalysts and application to enantioselective synthesis of quebrachamine: catalyst development inspired by natural product synthesis. 
  • Design of bioelectronic interfaces by exploiting hinge-bending motions in proteins. 
  • Design of protease-resistant peptide ligands for the purification of antibodies from human plasma. 
  • Design, selection, and development of cyclic peptide ligands for human erythropoietin. 
  • Design, synthesis and discovery of picomolar selective α4β2 nicotinic acetylcholine receptor ligands. 
  • Design, synthesis, and evaluation of linear and cyclic peptide ligands for PDZ10 of the multi-PDZ domain protein MUPP1. 
  • Detection and characterization of xenon-binding sites in proteins by 129Xe NMR spectroscopy. 
  • Development of a fluorescent ligand-binding assay using the AcroWell filter plate. 
  • Development of an ER action indicator mouse for the study of estrogens, selective ER modulators (SERMs), and Xenobiotics. 
  • Development of mammalian serum albumin affinity purification media by peptide phage display. 
  • Development of next-generation photolabile copper cages with improved copper binding properties. 
  • Development of peptide antagonists that target estrogen receptor beta-coactivator interactions. 
  • Developmental regulation of insulin-like growth factor binding protein production: studies in fetal, postnatal, and pregnant sheep. 
  • Differential gene expression in the distal tip endoderm of the embryonic mouse lung. 
  • Differential mapping of the amino acids mediating agonist and antagonist coordination with the human thromboxane A2 receptor protein. 
  • Differential presentation of protein interaction surfaces on the androgen receptor defines the pharmacological actions of bound ligands. 
  • Differential regulation of the dopamine D2 and D3 receptors by G protein-coupled receptor kinases and beta-arrestins. 
  • Dipeptidyl peptidase IV (DPP IV/CD26) is a cell-surface plasminogen receptor. 
  • Direct allosteric regulation between the GAF domain and catalytic domain of photoreceptor phosphodiesterase PDE6. 
  • Direct force measurements of the streptavidin-biotin interaction. 
  • Discovery of Key Physicochemical, Structural, and Spatial Properties of RNA-Targeted Bioactive Ligands. 
  • Discovery of Manassantin A Protein Targets Using Large-Scale Protein Folding and Stability Measurements. 
  • Discovery of Small Molecule Ligands for MALAT1 by Tuning an RNA-Binding Scaffold. 
  • Discovery of novel cyclophilin A ligands using an H/D exchange- and mass spectrometry-based strategy. 
  • Discovery of novel ligands for mouse olfactory receptor MOR42-3 using an in silico screening approach and in vitro validation. 
  • Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. 
  • Disruption of intrathymic CD4-Ia interactions on immature CD4+CD8+ thymocytes results in diminished TCR expression on mature CD8+ T cell progeny. 
  • Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors alpha and beta. 
  • Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation. 
  • Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation. 
  • Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors. 
  • Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties. 
  • Disulfide bond requirements for active Wnt ligands. 
  • Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR). 
  • Domain-specific effector interactions within the central cavity of human adult hemoglobin in solution and in porous sol-gel matrices: evidence for long-range communication pathways. 
  • Down-regulation of the orphan nuclear receptor ROR gamma t is essential for T lymphocyte maturation. 
  • Drug design from the cryptic inhibitor envelope. 
  • Dynamic Ligand Presentation in Biomaterials. 
  • Dynamic adhesion of umbilical cord blood endothelial progenitor cells under laminar shear stress. 
  • Dynamic functional evolution of an odorant receptor for sex-steroid-derived odors in primates. 
  • Dynamic seeding of perfusing human umbilical vein endothelial cells (HUVECs) onto dual-function cell adhesion ligands: Arg-Gly-Asp (RGD)-streptavidin and biotinylated fibronectin. 
  • Dynamic shuttling and intranuclear mobility of nuclear hormone receptors. 
  • Effect of IGFBP-3 on IGF- and IGF-analogue-induced insulin-like growth factor-I receptor (IGFIR) signalling. 
  • Effect of a 17alpha-(3-hydroxypropyl)-17beta-acetyl substituent pattern on the glucocorticoid and progestin receptor binding of 11beta-arylestra-4,9-dien-3-ones. 
  • Effect of protein fusion on the transition temperature of an environmentally responsive elastin-like polypeptide: a role for surface hydrophobicity? 
  • Effect of receptor-ligand affinity on the strength of endothelial cell adhesion. 
  • Effect of streptavidin affinity mutants on the integrin-independent adhesion of biotinylated endothelial cells. 
  • Effect-Directed Analysis of Human Peroxisome Proliferator-Activated Nuclear Receptors (PPARγ1) Ligands in Indoor Dust. 
  • Effects of chronic sazetidine-A, a selective α4β2 neuronal nicotinic acetylcholine receptors desensitizing agent on pharmacologically-induced impaired attention in rats. 
  • Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout mice. 
  • Effects of ligand binding on the mechanical properties of ankyrin repeat protein gankyrin. 
  • Electron paramagnetic resonance and optical evidence for interaction between siroheme and Fe4S4 prosthetic groups in complexes of Escherichia coli sulfite reductase hemoprotein with added ligands. 
  • Elevation of Stromal-Derived Mediators of Inflammation Promote Prostate Cancer Progression in African-American Men. 
  • Elucidating structural and molecular mechanisms of β-arrestin-biased agonism at GPCRs via MS-based proteomics. 
  • Embryonic cardiotoxicity of weak aryl hydrocarbon receptor agonists and CYP1A inhibitor fluoranthene in the Atlantic killifish (Fundulus heteroclitus). 
  • Endocytosis of the type III transforming growth factor-beta (TGF-beta) receptor through the clathrin-independent/lipid raft pathway regulates TGF-beta signaling and receptor down-regulation. 
  • Engagement of the adhesion receptor CD22 triggers a potent stimulatory signal for B cells and blocking CD22/CD22L interactions impairs T-cell proliferation. 
  • Enhanced HIV-1 neutralization by a CD4-VH3-IgG1 fusion protein. 
  • Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. 
  • Epiregulin and EGFR interactions are involved in pain processing. 
  • Erythrocyte invasion profiles are associated with a common invasion ligand polymorphism in Senegalese isolates of Plasmodium falciparum. 
  • Erythropoietin and erythropoietin receptor expression in head and neck cancer: relationship to tumor hypoxia. 
  • Escherichia coli sulfite reductase hemoprotein subunit. Prosthetic groups, catalytic parameters, and ligand complexes. 
  • Estrogen receptor-cofactor interactions as targets for novel drug discovery. 
  • Evaluating cell-surface expression and measuring activation of mammalian odorant receptors in heterologous cells. 
  • Evidence for Dual Binding Sites for 1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) in Insect Sodium Channels. 
  • Evidence that electrostatic interactions dictate the ligand-induced arrest of RNA global flexibility. 
  • Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone. 
  • Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2. 
  • Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor. 
  • Exploiting heat shock protein expression to develop a non-invasive diagnostic tool for breast cancer. 
  • Exploring molecular diversity with combinatorial shape libraries. 
  • Expression analysis of the T-cell-targeting chemokines CXCL9 and CXCL10 in mice and humans with endothelial infections caused by rickettsiae of the spotted fever group. 
  • Expression of CD1d and ligand-induced cytokine production are tissue specific in mucosal epithelia of the human lower reproductive tract. 
  • Expression of Toll-like receptors in human endometrial epithelial cells and cell lines. 
  • Extracellular annexin II. 
  • FGF signals guide migration of mesenchymal cells, control skeletal morphogenesis [corrected] and regulate gastrulation during sea urchin development. 
  • False-positive rate determination of protein target discovery using a covalent modification- and mass spectrometry-based proteomics platform. 
  • Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations. 
  • Fe(III) coordination properties of a new saccharide-based exocyclic trihydroxamate analogue of ferrichrome. 
  • Fe(III) coordination properties of two new saccharide-based enterobactin analogues: methyl 2,3,4-tris-O-[N-[2,3-di(hydroxy)benzoyl-glycyl]-aminopropyl]-alpha-D-glucopyranoside and methyl 2,3,4-tris-O-[N-[2,3-di-(hydroxy)-benzoyl]-aminopropyl]-alpha-D-glucopyranoside. 
  • Feedback control of T-cell receptor activation. 
  • Femtomolar sensitivity using a channel-etched thin film waveguide fluoroimmunosensor. 
  • Fibronectin and avidin-biotin as a heterogeneous ligand system for enhanced endothelial cell adhesion. 
  • First-Principles Molecular Structure Search with a Genetic Algorithm. 
  • Flg22-induced Ca²⁺ increases undergo desensitization and resensitization. 
  • Fluorescence energy transfer between ligand binding sites on aspartate transcarbamylase. 
  • Fluorescence energy transfer between ligand binding sites on chloroplast coupling factor 1. 
  • Fluorescence energy transfer between the thiamine diphosphate and flavine adenine dinucleotide binding sites on the pyruvate dehydrogenase multienzyme complex. 
  • Fluorescent indicator displacement assays to identify and characterize small molecule interactions with RNA. 
  • Folate targeting of drug carriers: a mathematical model. 
  • Fragment-Based De Novo Design Reveals a Small-Molecule Inhibitor of Helicobacter Pylori HtrA. 
  • Frameworks for targeting RNA with small molecules. 
  • From ligand binding to gene expression: new insights into the regulation of G-protein-coupled receptors. 
  • Full-electron ligand-to-ligand charge transfer in a compact Re(I) complex. 
  • Functional analysis of the TAN-1 gene, a human homolog of Drosophila notch. 
  • Functional consequences of ligand-linked dissociation in hemoglobin from the sea cucumber Molpadia arenicola. 
  • Functional evolution of mammalian odorant receptors. 
  • Functional expression of Mammalian odorant receptors. 
  • Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor. 
  • Functional properties of carboxypeptidase-digested hemoglobins. 
  • Further studies on platelet serotonin transporter binding in depression. 
  • G Protein-Coupled Receptor Endocytosis Confers Uniformity in Responses to Chemically Distinct Ligands. 
  • G Protein-coupled Receptor Biased Agonism. 
  • G protein-coupled receptor Gpr4 senses amino acids and activates the cAMP-PKA pathway in Cryptococcus neoformans. 
  • G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulation. 
  • GPCR systems pharmacology: a different perspective on the development of biased therapeutics. 
  • GQ-16, a novel peroxisome proliferator-activated receptor γ (PPARγ) ligand, promotes insulin sensitization without weight gain. 
  • GRP78: a chaperone with diverse roles beyond the endoplasmic reticulum. 
  • GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity. 
  • Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand. 
  • Gene delivery systems in surgery. 
  • Generation of species cross-reactive aptamers using "toggle" SELEX. 
  • Genetic deletion of the Tas2r143/Tas2r135/Tas2r126 cluster reveals that TAS2Rs may not mediate bitter tastant-induced bronchodilation. 
  • Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). 
  • Glomerular atrial natriuretic factor receptors in primary glomerulopathies: studies on human renal biopsies. 
  • Glucose-regulated protein (GRP78) is an important cell surface receptor for viral invasion, cancers, and neurological disorders. 
  • Glutamate receptor desensitization is mediated by changes in quaternary structure of the ligand binding domain. 
  • Gold(I)-catalyzed intramolecular enantioselective hydroalkoxylation of allenes. 
  • Gold(I)-catalyzed intramolecular enantioselective hydroarylation of allenes with indoles. 
  • Gold(I)-catalyzed intramolecular hydroamination of unactivated C==C bonds with alkyl ammonium salts. 
  • Graphical analysis of 2-[18F]FA binding to nicotinic acetylcholine receptors in rhesus monkey brain. 
  • Guttiferone I, a new prenylated benzophenone from Garcinia humilis as a liver X receptor ligand. 
  • Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling. 
  • H/D exchange- and mass spectrometry-based strategy for the thermodynamic analysis of protein-ligand binding. 
  • HASF (C3orf58) is a novel ligand of the insulin-like growth factor 1 receptor. 
  • HIV envelope gp120 activates human arterial smooth muscle cells. 
  • Haploinsufficiency of the Notch Ligand DLL1 Causes Variable Neurodevelopmental Disorders. 
  • Hedgehog Signaling is Associated with Liver Response to Fractionated Irradiation in Mice. 
  • Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. 
  • Hel-N1, an RNA-binding protein, is a ligand for an A + U rich region of the GLUT1 3' UTR. 
  • Heme proteins and nitric oxide (NO): the neglected, eloquent chemistry in NO redox signaling and regulation. 
  • Hemoglobins from trout: structural and functional properties. 
  • Hepatic accumulation of Hedgehog-reactive progenitors increases with severity of fatty liver damage in mice. 
  • Hepatitis C virus NS5B polymerase: QM/MM calculations show the important role of the internal energy in ligand binding. 
  • Hepatocyte receptors for antithrombin III-proteinase complexes. 
  • Heptahelical terpsichory. Who calls the tune? 
  • Her4 mediates ligand-dependent antiproliferative and differentiation responses in human breast cancer cells. 
  • Hfq structure, function and ligand binding. 
  • Hierarchy of RNA functional dynamics. 
  • High affinity binding of [3H]epibatidine to rat brain membranes. 
  • High-affinity augmentation of endothelial cell attachment: long-term effects on focal contact and actin filament formation. 
  • High-throughput screening assay for the tunable selection of protein ligands. 
  • Highly efficient molybdenum-based catalysts for enantioselective alkene metathesis. 
  • Hot Spot Mutagenesis Improves the Functional Expression of Unique Mammalian Odorant Receptors. 
  • How do halogen substituents contribute to protein-binding interactions? A thermodynamic study of peptide ligands with diverse aryl halides. 
  • Human GFRA1: cloning, mapping, genomic structure, and evaluation as a candidate gene for Hirschsprung disease susceptibility. 
  • Human PXR forms a tryptophan zipper-mediated homodimer. 
  • Human colon cancer cells express multiple glycoprotein ligands for E-selectin. 
  • Human olfactory receptor responses to odorants. 
  • Hydrogen/deuterium exchange- and protease digestion-based screening assay for protein-ligand binding detection. 
  • IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex. 
  • Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma. 
  • Identification of Drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions. 
  • Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance. 
  • Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation. 
  • Identification of cognate ligands for the Escherichia coli phnD protein product and engineering of a reagentless fluorescent biosensor for phosphonates. 
  • Identification of ligand-selective peptide antagonists of the mineralocorticoid receptor using phage display. 
  • Identification of novel innate immune genes by transcriptional profiling of macrophages stimulated with TLR ligands. 
  • Identification of specific protein-RNA target sites using libraries of natural sequences. 
  • Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands. 
  • Identification of the ligand-binding domains of CD22, a member of the immunoglobulin superfamily that uniquely binds a sialic acid-dependent ligand. 
  • Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands. 
  • Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer. 
  • Impact of toll-like receptor 4 deficiency on the response to uterine ischemia/reperfusion in mice. 
  • Improved synthesis and metabolic stability analysis of the dopamine transporter ligand [(18)F]FECT. 
  • Improving sensitivity and specificity of capturing and detecting targeted cancer cells with anti-biofouling polymer coated magnetic iron oxide nanoparticles. 
  • In Vivo Detection of HSP90 Identifies Breast Cancers with Aggressive Behavior. 
  • In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides. 
  • In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. 
  • In vitro assessment of human nuclear hormone receptor activity and cytotoxicity of the flame retardant mixture FM 550 and its triarylphosphate and brominated components. 
  • In vitro characterization of 6-[18F]fluoro-A-85380, a high-affinity ligand for alpha4beta2* nicotinic acetylcholine receptors. 
  • In vivo and in vitro examination of stability of primary hyperoxaluria-associated human alanine:glyoxylate aminotransferase. 
  • In vivo identification of eugenol-responsive and muscone-responsive mouse odorant receptors. 
  • In vivo performance of dual ligand augmented endothelialized expanded polytetrafluoroethylene vascular grafts. 
  • In vivo studies with [125I]5-I-A-85380, a nicotinic acetylcholine receptor radioligand. 
  • In vivo tumor targeting by a NGR-decorated micelle of a recombinant diblock copolypeptide. 
  • Incorporation of designed extended chromophores into amphiphilic 4-helix bundle peptides for nonlinear optical biomolecular materials. 
  • Incorporation of non-proteolytic proteins by murine alpha2-macroglobulin. 
  • Increased epidermal growth factor-like ligands are associated with elevated vascular nicotinamide adenine dinucleotide phosphate oxidase in a primate model of atherosclerosis. 
  • Increased production of sonic hedgehog by ballooned hepatocytes. 
  • Induction of autocrine epidermal growth factor receptor ligands in human keratinocytes by insulin/insulin-like growth factor-1. 
  • Influence of dimethylsulfoxide on RNA structure and ligand binding. 
  • Inhibition of DNA helicase II unwinding and ATPase activities by DNA-interacting ligands. Kinetics and specificity. 
  • Inhibition of cell proliferation by an RNA ligand that selectively blocks E2F function. 
  • Inhibition of endoglin-GIPC interaction inhibits pancreatic cancer cell growth. 
  • Inhibition of prostate cancer cell growth by second-site androgen receptor antagonists. 
  • Inhibitors of platelet adhesion. 
  • Insights into the development of chemical probes for RNA. 
  • Integrated in silico and experimental discovery of trimeric peptide ligands targeting Butyrylcholinesterase. 
  • Interaction of aspartate transcarbamylase with 5-bromocytidine 5'-tri-, di-, and monophosphates. 
  • Interaction of prenylcysteine methyl esters with the multidrug resistance transporter. 
  • Interferon regulatory factor-1-induced apoptosis mediated by a ligand-independent fas-associated death domain pathway in breast cancer cells. 
  • International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors. 
  • Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer. 
  • Involvement of the distal histidine in the low affinity exhibited by Hb Chico (Lys beta 66----Thr) and its isolated beta chains. 
  • Iron chelation properties of an extracellular siderophore exochelin MS. 
  • Isolated beta-adrenergic binding sites: a potential assay vehicle for catecholamines. 
  • Isolation and characterization of the beta-adrenergic receptor of frog erythrocytes and development of potential affinity ligands. 
  • Isomeric N-alkylpyridylporphyrins and their Zn(II) complexes: inactive as SOD mimics but powerful photosensitizers. 
  • Itch control by Toll-like receptors. 
  • Iterative in situ click chemistry creates antibody-like protein-capture agents. 
  • K12/SECTM1, an interferon-γ regulated molecule, synergizes with CD28 to costimulate human T cell proliferation. 
  • Kinetic analysis of zinc ligand mutants of mammalian protein farnesyltransferase. 
  • Kinetic studies of protein farnesyltransferase mutants establish active substrate conformation. 
  • Kinetics and mechanism of iron(III) complexation by ferric binding protein: the role of phosphate. 
  • Kinetics of TCR use in response to repeated epitope-specific immunization. 
  • Kinetics of allosteric enzymes. 
  • Kinetics of nonproteolytic incorporation of a protein ligand into thermally activated alpha 2-macroglobulin: evidence for a novel nascent state. 
  • L-DOPA is an endogenous ligand for OA1. 
  • L-selectin dimerization enhances tether formation to properly spaced ligand. 
  • L-selectin ligands expressed by human leukocytes are HECA-452 antibody-defined carbohydrate epitopes preferentially displayed by P-selectin glycoprotein ligand-1. 
  • Labeling internalizing anti-epidermal growth factor receptor variant III monoclonal antibody with (177)Lu: in vitro comparison of acyclic and macrocyclic ligands. 
  • Lack of p38 MAP kinase activation in TRAIL-resistant cells is not related to the resistance to TRAIL-mediated cell death. 
  • Lateral density of receptor arrays in the membrane plane influences sensitivity of the E. coli chemotaxis response. 
  • Letal, A tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells. 
  • Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion. 
  • Life is sweet: the cell biology of glycoconjugates. 
  • Ligand binding to the LFA-3 cell adhesion molecule induces IL-1 production by human thymic epithelial cells. 
  • Ligand binding to transiently accessible sites: mechanisms for varying apparent binding rates. 
  • Ligand binding, conformational change and plasma elimination of human, mouse and rat alpha-macroglobulin proteinase inhibitors. 
  • Ligand concentration regulates the pathways of coupled protein folding and binding. 
  • Ligand interactions in the adenosine nucleotide-binding domain of the Hsp90 chaperone, GRP94. I. Evidence for allosteric regulation of ligand binding. 
  • Ligand interactions in the adenosine nucleotide-binding domain of the Hsp90 chaperone, GRP94. II. Ligand-mediated activation of GRP94 molecular chaperone and peptide binding activity. 
  • Ligand-binding residues integrate affinity and efficacy in the NMDA receptor. 
  • Ligand-dependent genomic function of glucocorticoid receptor in triple-negative breast cancer. 
  • Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts. 
  • Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling. 
  • Ligand-independent toll-like receptor signals generated by ectopic overexpression of MyD88 generate local and systemic antitumor immunity. 
  • Ligand-induced conformational changes in a thermophilic ribose-binding protein. 
  • Ligand-induced overexpression of a constitutively active beta2-adrenergic receptor: pharmacological creation of a phenotype in transgenic mice. 
  • Ligand-induced recruitment of a histone deacetylase in the negative-feedback regulation of the thyrotropin beta gene. 
  • Ligand-selective interactions of ER detected in living cells by fluorescence resonance energy transfer. 
  • Ligand-specific dynamics of the androgen receptor at its response element in living cells. 
  • Ligand-specific selection of MHC class II-restricted thymocytes in fetal thymic organ culture. 
  • Ligation of cell surface-associated glucose-regulated protein 78 by receptor-recognized forms of alpha 2-macroglobulin: activation of p21-activated protein kinase-2-dependent signaling in murine peritoneal macrophages. 
  • Ligation of low-density lipoprotein receptor-related protein with antibodies elevates intracellular calcium and inositol 1,4, 5-trisphosphate in macrophages. 
  • Ligation of the alpha2M signaling receptor with receptor-recognized forms of alpha2-macroglobulin initiates protein and DNA synthesis in macrophages. The effect of intracellular calcium. 
  • Ligation of the alpha2M* signaling receptor regulates synthesis of cytosolic phospholipase A2. 
  • Ligation-state hydrogen exchange: coupled binding and folding equilibria in ribonuclease P protein. 
  • Light chains are a ligand for megalin. 
  • Light uncages a copper complex to induce nonapoptotic cell death. 
  • Linked folding and anion binding of the Bacillus subtilis ribonuclease P protein. 
  • Linking ligand-induced alterations in androgen receptor structure to differential gene expression: a first step in the rational design of selective androgen receptor modulators. 
  • Location bias contributes to functionally selective responses of biased CXCR3 agonists. 
  • Log-Rank Test vs MaxCombo and Difference in Restricted Mean Survival Time Tests for Comparing Survival Under Nonproportional Hazards in Immuno-oncology Trials: A Systematic Review and Meta-analysis. 
  • Long-term chemogenetic activation of M1 glutamatergic neurons attenuates the behavioral and cognitive deficits caused by intracerebral hemorrhage. 
  • Loss of Lrig1 leads to expansion of Brunner glands followed by duodenal adenomas with gastric metaplasia. 
  • Loss of biased signaling at a G protein-coupled receptor in overexpressed systems. 
  • Lung-specific overexpression of CC chemokine ligand (CCL) 2 enhances the host defense to Streptococcus pneumoniae infection in mice: role of the CCL2-CCR2 axis. 
  • Ly49-dependent NK cell licensing and effector inhibition involve the same interaction site on MHC ligands. 
  • Lysosome-Rich Enterocytes Mediate Protein Absorption in the Vertebrate Gut. 
  • MAIT and Vδ2 unconventional T cells are supported by a diverse intestinal microbiome and correlate with favorable patient outcome after allogeneic HCT. 
  • MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons. 
  • ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse. 
  • Machine Learning Assisted Approach for Finding Novel High Activity Agonists of Human Ectopic Olfactory Receptors. 
  • Macrophage-derived Hedgehog ligands promotes fibrogenic and angiogenic responses in human schistosomiasis mansoni. 
  • Mammalian alpha 1-adrenergic receptor. Purification and characterization of the native receptor ligand binding subunit. 
  • Manipulation of ligand binding affinity by exploitation of conformational coupling. 
  • Mapping Angiotensin II Type 1 Receptor-Biased Signaling Using Proximity Labeling and Proteomics Identifies Diverse Actions of Biased Agonists. 
  • Mapping of a ligand-binding site for the human thromboxane A2 receptor protein. 
  • Mass spectrometry- and lysine amidination-based protocol for thermodynamic analysis of protein folding and ligand binding interactions. 
  • Mass spectrometry-based thermal shift assay for protein-ligand binding analysis. 
  • Mechanism of time-dependent inhibition of 5 alpha-reductases by delta 1-4-azasteroids: toward perfection of rates of time-dependent inhibition by using ligand-binding energies. 
  • Megalin mediates renal uptake of heavy metal metallothionein complexes. 
  • Mesenchymal stem cells differentiate into renin-producing juxtaglomerular (JG)-like cells under the control of liver X receptor-alpha. 
  • Mesenchymal stem cells use integrin beta1 not CXC chemokine receptor 4 for myocardial migration and engraftment. 
  • Metal sites of copper-zinc superoxide dismutase. 
  • Methods for the detection of altered beta-adrenergic receptor signaling pathways in hypertrophied hearts. 
  • MicroRNA-182 and microRNA-200a control G-protein subunit α-13 (GNA13) expression and cell invasion synergistically in prostate cancer cells. 
  • Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome. 
  • Microporous annealed particle hydrogel stiffness, void space size, and adhesion properties impact cell proliferation, cell spreading, and gene transfer. 
  • Model peptides provide new insights into the role of histidine residues as potential ligands in human cellular copper acquisition via Ctr1. 
  • Modified T-cell receptor ligands: moving beyond a strict occupancy model for T-cell activation by antigen. 
  • Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. 
  • Molecular biology. Versatility of self-cleaving ribozymes. 
  • Molecular determinants in the second intracellular loop of the 5-hydroxytryptamine-1A receptor for G-protein coupling. 
  • Molecular interactions of B-CAM (basal-cell adhesion molecule) and laminin in epithelial skin cancer. 
  • Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors. 
  • Molecular mechanisms of beta-adrenergic receptor desensitization. 
  • Molecular pharmacology of alpha adrenergic receptors: utilization of [3H]dihydroergocryptine binding in the study of pharmacological receptor alterations. 
  • Monocyte chemotactic peptide receptor. Functional characteristics and ligand-induced regulation. 
  • Morphing low-affinity ligands into high-avidity nanoparticles by thermally triggered self-assembly of a genetically encoded polymer. 
  • Multidimensional de novo design reveals 5-HT2B receptor-selective ligands. 
  • Multifactorial optimization of endothelial cell growth using modular synthetic extracellular matrices. 
  • Multiple ligand-specific conformations of the β2-adrenergic receptor. 
  • Multivalency effects in protein--carbohydrate interaction: the binding of the Shiga-like toxin 1 binding subunit to multivalent C-linked glycopeptides. 
  • Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis. 
  • Myeloma light chains are ligands for cubilin (gp280). 
  • N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents. 
  • Natural product ligands of FKBP12: Immunosuppressive antifungal agents FK506, rapamycin, and beyond. 
  • Neuregulin-induced expression of the acetylcholine receptor requires endocytosis of ErbB receptors. 
  • Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding. 
  • Neuroprotection mediated through estrogen receptor-alpha in astrocytes. 
  • Neurotensin receptor 1-biased ligand attenuates neurotensin-mediated excitation of ventral tegmental area dopamine neurons and dopamine release in the nucleus accumbens. 
  • New perspectives regarding β(2) -adrenoceptor ligands in the treatment of asthma. 
  • Newspapers and newspaper ink contain agonists for the ah receptor. 
  • Niacin in cardiovascular prevention: mechanisms, efficacy, and safety. 
  • Non-alcoholic steatohepatitis pathogenesis: role of repair in regulating the disease progression. 
  • Noncanonical agonist PPARγ ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy. 
  • Nonproteolytic incorporation of protein ligands into human alpha 2-macroglobulin: implications for the binding mechanism of alpha 2-macroglobulin. 
  • Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism. 
  • Novel critical role of Toll-like receptor 4 in lung ischemia-reperfusion injury and edema. 
  • Nuclear magnetic resonance study of ligand binding to Mn-aspartate transcarbamylase. 
  • Nucleic acid-binding polymers as anti-inflammatory agents. 
  • Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation. 
  • Olfactory receptors in macrophages and inflammation. 
  • Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1. 
  • Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in pulmonary fibroblasts. 
  • Optimization of a Noncanonical Anti-infective: Interrogation of the Target Binding Pocket for a Small-Molecule Inhibitor of Escherichia coli Polysaccharide Capsule Expression. 
  • Optimization of the sequence of antigen loading and CD40-ligand-induced maturation of dendritic cells. 
  • Osmolyte-induced folding of an intrinsically disordered protein: folding mechanism in the absence of ligand. 
  • Osteopontin inhibits expression of cytochrome c oxidase in RAW 264.7 murine macrophages. 
  • Ovarian carcinoma expresses the NKG2D ligand Letal and promotes the survival and expansion of CD28- antitumor T cells. 
  • Overview of the Alliance for Cellular Signaling. 
  • Oxygen binding domains of Helisoma trivolvis hemoglobin. 
  • PEGylated gold nanoparticles conjugated to monoclonal F19 antibodies as targeted labeling agents for human pancreatic carcinoma tissue. 
  • PPAR alpha ligand protects during cisplatin-induced acute renal failure by preventing inhibition of renal FAO and PDC activity. 
  • PPARgamma agonists follow an unknown TRAIL in lung cancer. 
  • Painting proteins with covalent labels: what's in the picture? 
  • Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad. 
  • Peptide antagonists of the human estrogen receptor. 
  • Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling. 
  • Periplasmic binding proteins: a versatile superfamily for protein engineering. 
  • Pharmacological Wnt ligand inhibition overcomes key tumor-mediated resistance pathways to anti-PD-1 immunotherapy. 
  • Phosphorylation of RNA polymerase II CTD fragments results in tight binding to the WW domain from the yeast prolyl isomerase Ess1. 
  • Physiological and molecular basis of thyroid hormone action. 
  • Physiological impact of increased expression of the AT1 angiotensin receptor. 
  • Physiopathologic role of cubilin and megalin. 
  • Phytol metabolites are circulating dietary factors that activate the nuclear receptor RXR. 
  • Picomole-scale characterization of protein stability and function by quantitative cysteine reactivity. 
  • Plasmin binding to the plasminogen receptor enhances catalytic efficiency and activates the receptor for subsequent ligand binding. 
  • Platelet alpha2-adrenergic receptor coupling efficiency to Gi protein in subjects with post-traumatic stress disorder and normal controls. 
  • Platelet-derived growth factor receptors: a therapeutic target in solid tumors. 
  • Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid. 
  • Positive regulation of the vitamin D receptor by its cognate ligand in heterologous expression systems. 
  • Potent anticoagulant aptamer directed against factor IXa blocks macromolecular substrate interaction. 
  • Precipitation and growth of Zn-sulfide nanoparticles in the presence of thiol-containing natural organic ligands 
  • Predicting protein-ligand interactions based on bow-pharmacological space and Bayesian additive regression trees. 
  • Preliminary structural studies on the multi-ligand-binding domain of the transcription activator, BmrR, from Bacillus subtilis. 
  • Preparation of Rh[16aneS4-diol](211)At and Ir[16aneS4-diol](211)At complexes as potential precursors for astatine radiopharmaceuticals. Part I: Synthesis. 
  • Probing domain interactions in soluble guanylate cyclase. 
  • Probing the Allosteric Role of the α5 Subunit of α3β4α5 Nicotinic Acetylcholine Receptors by Functionally Selective Modulators and Ligands. 
  • Probing the catalytic mechanism of sulfite reductase by X-ray crystallography: structures of the Escherichia coli hemoprotein in complex with substrates, inhibitors, intermediates, and products. 
  • Probing the folding intermediate of Bacillus subtilis RNase P protein by nuclear magnetic resonance. 
  • Probing the stability of native and activated forms of alpha2-macroglobulin. 
  • Prochelators triggered by hydrogen peroxide provide hexadentate iron coordination to impede oxidative stress. 
  • Progesterone receptor interacting coregulatory proteins and cross talk with cell signaling pathways. 
  • Programmable DNA self-assemblies for nanoscale organization of ligands and proteins. 
  • Programmable ligand detection system in plants through a synthetic signal transduction pathway. 
  • Programming the magnitude and persistence of antibody responses with innate immunity. 
  • Protein dynamic studies move to a new time slot. 
  • Proteome-Wide Structural Biology: An Emerging Field for the Structural Analysis of Proteins on the Proteomic Scale. 
  • Prothymosin-alpha inhibits HIV-1 via Toll-like receptor 4-mediated type I interferon induction. 
  • Proton NMR of Escherichia coli sulfite reductase: studies of the heme protein subunit with added ligands. 
  • Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands. 
  • Quantifying intrinsic specificity: a potential complement to affinity in drug screening. 
  • Quantifying ligand bias at seven-transmembrane receptors. 
  • Quantitative Study of the Interaction of Multivalent Ligand-Modified Nanoparticles with Breast Cancer Cells with Tunable Receptor Density. 
  • Quantitative measurement of cell adhesion using centrifugal force. 
  • R-BIND 2.0: An Updated Database of Bioactive RNA-Targeting Small Molecules and Associated RNA Secondary Structures. 
  • R-BIND: An Interactive Database for Exploring and Developing RNA-Targeted Chemical Probes. 
  • RNA aptamer-based functional ligands of the neurotrophin receptor, TrkB. 
  • RNA dynamics by design: biasing ensembles towards the ligand-bound state. 
  • RTP family members induce functional expression of mammalian odorant receptors. 
  • Radiommunoassay of delta9-tetrahydrocannabinol. 
  • Radiosynthesis of 5-(2-(4-pyridinyl)vinyl)-6-chloro-3-(1-[(11)C]methyl-2-(S)-pyrrolidinylmethoxy)pyridine, a high affinity ligand for studying nicotinic acetylcholine receptors by positron emission tomography. 
  • Randomization and selection of RNA to identify targets for RRM RNA-binding proteins and antibodies. 
  • Rapid detection of the Fc gamma RIIA-H/R 131 ligand-binding polymorphism using an allele-specific restriction enzyme digestion (ASRED). 
  • Re-examination of CD91 function in GRP94 (glycoprotein 96) surface binding, uptake, and peptide cross-presentation. 
  • Reaction mechanisms of mononuclear non-heme iron oxygenases. 
  • Recent developments in biased agonism. 
  • Receptor-associated protein binding blocks ubiquitinylation of the low density lipoprotein receptor-related protein. 
  • Receptor-transporting protein 1 short (RTP1S) mediates translocation and activation of odorant receptors by acting through multiple steps. 
  • Recognition of lysine-rich peptide ligands by murine cortactin SH3 domain: CD, ITC, and NMR studies. 
  • Recognition of multiple drugs by a single protein: a trivial solution of an old paradox. 
  • Recombinant Rhodobacter capsulatus xanthine dehydrogenase, a useful model system for the characterization of protein variants leading to xanthinuria I in humans. 
  • Reconstitution of functional membrane-bound acetylcholine receptor from isolated Torpedo californica receptor protein and electroplax lipids. 
  • Region-specific antiglucocorticoid receptor antibodies selectively recognize the activated form of the ligand-occupied receptor and inhibit the binding of activated complexes to deoxyribonucleic acid. 
  • Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function. 
  • Regulation of MALAT1 triple helix stability and in vitro degradation by diphenylfurans. 
  • Regulation of casein kinase I epsilon activity by Wnt signaling. 
  • Regulation of the dynamics of hsp90 action on the glucocorticoid receptor by acetylation/deacetylation of the chaperone. 
  • Relationship between the G protein signaling and homologous desensitization of G protein-coupled receptors. 
  • Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with cytidine 5'-triphosphate. 
  • Release of glutamate and aspartate from CA1 synaptosomes: selective modulation of aspartate release by ionotropic glutamate receptor ligands. 
  • Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells. 
  • Resonance Raman studies of Escherichia coli sulfite reductase hemoprotein. 3. Bound ligand vibrational modes. 
  • Role for hedgehog signaling in hepatic stellate cell activation and viability. 
  • Role of Toll-like receptors in HMGB1 release from macrophages. 
  • Role of extracellular disulfide-bonded cysteines in the ligand binding function of the beta 2-adrenergic receptor. 
  • Role of the aryl hydrocarbon receptor in cell cycle regulation. 
  • Role of transforming growth factor-beta superfamily signaling pathways in human disease. 
  • S-Adenosylhomocysteine hydrolase from human placenta. Affinity purification and characterization. 
  • S-Nitrosylation of β-Arrestins Biases Receptor Signaling and Confers Ligand Independence. 
  • S-nitrosoglutathione inhibits alpha1-adrenergic receptor-mediated vasoconstriction and ligand binding in pulmonary artery. 
  • S-nitrosylation of beta-arrestin regulates beta-adrenergic receptor trafficking. 
  • SECTM1 produced by tumor cells attracts human monocytes via CD7-mediated activation of the PI3K pathway. 
  • SILAC-pulse proteolysis: A mass spectrometry-based method for discovery and cross-validation in proteome-wide studies of ligand binding. 
  • SREC-I, a type F scavenger receptor, is an endocytic receptor for calreticulin. 
  • Safety, pharmacokinetics, pharmacodynamics, and antitumor activity of dalantercept, an activin receptor-like kinase-1 ligand trap, in patients with advanced cancer. 
  • Sazetidine-A, a selective α4β2 nicotinic acetylcholine receptor ligand: effects on dizocilpine and scopolamine-induced attentional impairments in female Sprague-Dawley rats. 
  • Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1. 
  • Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands. 
  • Self and non-self discrimination of intracellular membranes by the innate immune system. 
  • Sensorimotor deficits and increased brain nicotinic acetylcholine receptors following exposure to chlorpyrifos and/or nicotine in rats. 
  • Sequential roles of Hedgehog and Wnt signaling in osteoblast development. 
  • Shaping the Immune Landscape in Cancer by Galectin-Driven Regulatory Pathways. 
  • Signaling activities of the Drosophila wingless gene are separately mutable and appear to be transduced at the cell surface. 
  • Signaling, desensitization, and trafficking of G protein-coupled receptors revealed by green fluorescent protein conjugates. 
  • Signals from dying hepatocytes trigger growth of liver progenitors. 
  • Similarities between inorganic sulfide and the strong Hg(II)-complexing ligands in municipal wastewater effluent. 
  • Single cell analysis of cribriform prostate cancer reveals cell intrinsic and tumor microenvironmental pathways of aggressive disease. 
  • Single transcriptional and translational preQ1 riboswitches adopt similar pre-folded ensembles that follow distinct folding pathways into the same ligand-bound structure. 
  • Site-directed mutagenesis of recombinant sulfite oxidase: identification of cysteine 207 as a ligand of molybdenum. 
  • Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination. 
  • Small molecule targeting of biologically relevant RNA tertiary and quaternary structures. 
  • Small molecule-RNA targeting: starting with the fundamentals. 
  • Solid-phase synthesis for the identification of high-affinity bivalent lectin ligands. 
  • Soluble monomeric P-selectin containing only the lectin and epidermal growth factor domains binds to P-selectin glycoprotein ligand-1 on leukocytes. 
  • Solution structure and function of YndB, an AHSA1 protein from Bacillus subtilis. 
  • Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells. 
  • Sonic hedgehog ligand partners with caveolin-1 for intracellular transport. 
  • Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design. 
  • Specificity of C-glycoside complexation by mannose/glucose specific lectins. 
  • Sphingosine-1-phosphate inhibits IL-1-induced expression of C-C motif ligand 5 via c-Fos-dependent suppression of IFN-β amplification loop. 
  • Spotting and designing promiscuous ligands for drug discovery. 
  • Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor. 
  • Stabilizing exposure of conserved epitopes by structure guided insertion of disulfide bond in HIV-1 envelope glycoprotein. 
  • Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation. 
  • Steroidal and triterpenoidal fungal metabolites as ligands of liver X receptors. 
  • Streptavidin binding and endothelial cell adhesion to biotinylated fibronectin. 
  • Streptavidin-biotin binding energetics. 
  • Stromal complement receptor CD21/35 facilitates lymphoid prion colonization and pathogenesis. 
  • Strong hg(II) complexation in municipal wastewater effluent and surface waters. 
  • Structural adaptations that modulate monosaccharide, disaccharide, and trisaccharide specificities in periplasmic maltose-binding proteins. 
  • Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis. 
  • Structural analysis of a periplasmic binding protein in the tripartite ATP-independent transporter family reveals a tetrameric assembly that may have a role in ligand transport. 
  • Structural and Biochemical Characterization of the Francisella tularensis Pathogenicity Regulator, Macrophage Locus Protein A (MglA). 
  • Structural and Dynamic Basis for Low-Affinity, High-Selectivity Binding of L-Glutamine by the Glutamine Riboswitch. 
  • Structural and functional interactions between six-transmembrane μ-opioid receptors and β2-adrenoreceptors modulate opioid signaling. 
  • Structural and thermodynamic characterization of a cytoplasmic dynein light chain-intermediate chain complex. 
  • Structural basis for an unexpected mode of SERM-mediated ER antagonism. 
  • Structural basis for the metal-selective activation of the manganese transport regulator of Bacillus subtilis. 
  • Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter. 
  • Structural basis of salicylic acid perception by Arabidopsis NPR proteins. 
  • Structural dynamics of a single-stranded RNA-helix junction using NMR. 
  • Structural mechanism of glutamate receptor activation and desensitization. 
  • Structural mechanism of trimeric HIV-1 envelope glycoprotein activation. 
  • Structural requirements for high affinity ligand binding by estrogen receptors: a comparative analysis of truncated and full length estrogen receptors expressed in bacteria, yeast, and mammalian cells. 
  • Structural studies of amphiphilic 4-helix bundle peptides incorporating designed extended chromophores for nonlinear optical biomolecular materials. 
  • Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain. 
  • Structure and biological activity of (-)-[3H]dihydroalprenolol, a radioligand for studies of beta-adrenergic receptors. 
  • Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation. 
  • Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. 
  • Structure- and Ligand-Dynamics-Based Design of Novel Antibiotics Targeting Lipid A Enzymes LpxC and LpxH in Gram-Negative Bacteria. 
  • Structure-based design of robust glucose biosensors using a Thermotoga maritima periplasmic glucose-binding protein. 
  • Structure-based redesign of corepressor specificity of the Escherichia coli purine repressor by substitution of residue 190. 
  • Structure-functional selectivity relationship studies of β-arrestin-biased dopamine D₂ receptor agonists. 
  • Structure-guided DOT1L probe optimization by label-free ligand displacement. 
  • Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma. 
  • Structures of Cryptococcus neoformans protein farnesyltransferase reveal strategies for developing inhibitors that target fungal pathogens. 
  • Structures of human Patched and its complex with native palmitoylated sonic hedgehog. 
  • Structures of the siroheme- and Fe4S4-containing active center of sulfite reductase in different states of oxidation: heme activation via reduction-gated exogenous ligand exchange. 
  • Studies on the adapter molecule LAT. 
  • Subsensitivity of adenylate cyclase and decreased beta-adrenergic receptor binding after chronic exposure to (minus)-isoproterenol in vitro. 
  • Sulfate as a synergistic anion facilitating iron binding by the bacterial transferrin FbpA: the origins and effects of anion promiscuity. 
  • Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin. 
  • Synergistic effect of high-affinity binding and flow preconditioning on endothelial cell adhesion. 
  • Synthesis and characterization of copper(II) complexes of cysteinyldopa and benzothiazine model ligands related to pheomelanin. 
  • Synthesis and evaluation of a novel series of 2-chloro-5-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-3-(2-(4-pyridinyl)vinyl)pyridine analogues as potential positron emission tomography imaging agents for nicotinic acetylcholine receptors. 
  • Synthesis and iron sequestration equilibria of novel exocyclic 3-hydroxy-2-pyridinone donor group siderophore mimics. 
  • Synthesis and preliminary evaluation of 211At-labeled inhibitors of prostate-specific membrane antigen for targeted alpha particle therapy of prostate cancer. 
  • Synthesis and structure-activity relationship of a novel series of aminoalkylindoles with potential for imaging the neuronal cannabinoid receptor by positron emission tomography. 
  • Synthesis, fluorine-18 radiolabeling, and in vitro characterization of 1-iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivatives as potential PET radioligands for imaging peripheral benzodiazepine receptor. 
  • Synthesis, structure-activity relationship, and evaluation of SR141716 analogues: development of central cannabinoid receptor ligands with lower lipophilicity. 
  • Systematic errors in detecting biased agonism: Analysis of current methods and development of a new model-free approach. 
  • T-cell-receptor affinity and thymocyte positive selection. 
  • TNFR2 interposes the proliferative and NF-κB-mediated inflammatory response by podocytes to TNF-α. 
  • Targeted Mass Spectrometry-Based Approach for Protein-Ligand Binding Analyses in Complex Biological Mixtures Using a Phenacyl Bromide Modification Strategy. 
  • Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development. 
  • Targeting PDGF receptors in cancer--rationales and proof of concept clinical trials. 
  • Targeting RNA with small molecules: from fundamental principles towards the clinic. 
  • Targeting specific PDZ domains of PSD-95; structural basis for enhanced affinity and enzymatic stability of a cyclic peptide. 
  • Targeting the cyclophilin domain of Ran-binding protein 2 (Ranbp2) with novel small molecules to control the proteostasis of STAT3, hnRNPA2B1 and M-opsin. 
  • Teaching old receptors new tricks: biasing seven-transmembrane receptors. 
  • Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry. 
  • Temporally distinct and ligand-specific recruitment of nuclear receptor-interacting peptides and cofactors to subnuclear domains containing the estrogen receptor. 
  • The Affinity of Brominated Phenolic Compounds for Human and Zebrafish Thyroid Receptor β: Influence of Chemical Structure. 
  • The Aryl Hydrocarbon Receptor: A Mediator and Potential Therapeutic Target for Ocular and Non-Ocular Neurodegenerative Diseases. 
  • The Dysregulated Pharmacology of Clinically Relevant ESR1 Mutants is Normalized by Ligand-activated WT Receptor. 
  • The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner. 
  • The N- and C-terminal peptides of hIL8/CXCL8 are ligands for hCXCR1 and hCXCR2. 
  • The NMDA receptor M3 segment is a conserved transduction element coupling ligand binding to channel opening. 
  • The Notch Ligand Jagged1 Regulates the Osteoblastic Lineage by Maintaining the Osteoprogenitor Pool. 
  • The Novel Progesterone Receptor Antagonists RTI 3021-012 and RTI3021-022 Exhibit Complex Glucocorticoid Receptor Antagonist Activities: Implications for the Development of Dissociated Antiprogestins. 
  • The PDZ motif of the α1C subunit is not required for surface trafficking and adrenergic modulation of CaV1.2 channel in the heart. 
  • The Weak Link: Optimization of the Ligand-Nanoparticle Interface To Enhance Cancer Cell Targeting by Polymer Micelles. 
  • The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor. 
  • The beta-adrenergic receptor in heart failure. 
  • The beta-adrenergic receptor. 
  • The crystal structure of a thermophilic glucose binding protein reveals adaptations that interconvert mono and di-saccharide binding sites. 
  • The cubic ternary complex receptor-occupancy model. III. resurrecting efficacy. 
  • The cutaneous lymphocyte antigen is an essential component of the L-selectin ligand induced on human vascular endothelial cells. 
  • The dichotomous role of epiregulin in pain. 
  • The endothelial cell protein C receptor. Cell surface expression and direct ligand binding by the soluble receptor. 
  • The epidermal growth factor receptor and its ligands in cardiovascular disease. 
  • The extracellular matrix protein mindin serves as an integrin ligand and is critical for inflammatory cell recruitment. 
  • The future of organ and tissue transplantation: can T-cell costimulatory pathway modifiers revolutionize the prevention of graft rejection? 
  • The hedgehog pathway regulates remodelling responses to biliary obstruction in rats. 
  • The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist. 
  • The human estrogen receptor-alpha is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators. 
  • The influence of DNA sequence on the immunostimulatory properties of plasmid DNA vectors. 
  • The kinetics of dimethylhydroxypyridinone interactions with iron(iii) and the catalysis of iron(iii) ligand exchange reactions: implications for bacterial iron transport and combination chelation therapies. 
  • The ligand binding domain of the epidermal growth factor receptor is not required for receptor dimerization. 
  • The mechanisms of inactivation of sulfite oxidase by periodate and arsenite. 
  • The molecular basis for ligand specificity in a mouse olfactory receptor: a network of functionally important residues. 
  • The molecular mechanisms underlying the pharmacological actions of ER modulators: implications for new drug discovery in breast cancer. 
  • The multiple membrane spanning topography of the beta 2-adrenergic receptor. Localization of the sites of binding, glycosylation, and regulatory phosphorylation by limited proteolysis. 
  • The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor. 
  • The performance of ZDOCK and ZRANK in rounds 6-11 of CAPRI. 
  • The pre-ligand binding assembly domain: a potential target of inhibition of tumour necrosis factor receptor function. 
  • The relationship between ligand-binding thermodynamics and protein-ligand interaction forces measured by atomic force microscopy. 
  • The release of microparticles by RAW 264.7 macrophage cells stimulated with TLR ligands. 
  • The rho-guanine nucleotide exchange factor domain of obscurin regulates assembly of titin at the Z-disk through interactions with Ran binding protein 9. 
  • The role of KIR genes and their cognate HLA class I ligands in childhood acute lymphoblastic leukemia. 
  • The role of ligand-ligand interactions in competition by fibrinogen and fibrin degradation products for fibrinogen binding to human platelets. 
  • The role of the specificity-determining loop of the integrin beta subunit I-like domain in autonomous expression, association with the alpha subunit, and ligand binding. 
  • The stoichiometry of trimeric SIV glycoprotein interaction with CD4 differs from that of anti-envelope antibody Fab fragments. 
  • The structural mechanism of GTP stabilized oligomerization and catalytic activation of the Toxoplasma gondii uracil phosphoribosyltransferase. 
  • The uterine myometrium is a target for increased levels of activin A during pregnancy. 
  • The vitamin D receptor interacts preferentially with DRIP205-like LxxLL motifs. 
  • Therapeutic Aptamers: Evolving to Find their Clinical Niche. 
  • Thermodynamic analysis of a hydrophobic binding site: probing the PDZ domain with nonproteinogenic peptide ligands. 
  • Thermodynamic analysis of ligand-induced changes in protein thermal unfolding applied to high-throughput determination of ligand affinities with extrinsic fluorescent dyes. 
  • Thermodynamic analysis of protein stability and ligand binding using a chemical modification- and mass spectrometry-based strategy. 
  • Thermodynamic analysis of protein-ligand binding interactions in complex biological mixtures using the stability of proteins from rates of oxidation. 
  • Thermodynamic characterization of the osmolyte- and ligand-folded states of Bacillus subtilis ribonuclease P protein. 
  • Thermodynamic profiling of conformationally constrained cyclic ligands for the PDZ domain. 
  • Thermodynamics of metal ion binding. 1. Metal ion binding by wild-type carbonic anhydrase. 
  • Thermodynamics of metal ion binding. 2. Metal ion binding by carbonic anhydrase variants. 
  • Thermodynamics, kinetics, and mechanism of the stepwise dissociation and formation of Tris(L-lysinehydroxamato)iron(III) in aqueous acid. 
  • Three is better than one: pre-ligand receptor assembly in the regulation of TNF receptor signaling. 
  • Three-dimensional micropatterning of bioactive hydrogels via two-photon laser scanning photolithography for guided 3D cell migration. 
  • Thrombin receptor. Variations on a theme. 
  • Throughput and efficiency of a mass spectrometry-based screening assay for protein-ligand binding detection. 
  • Toll-like receptor 3 adjuvant in combination with virus-like particles elicit a humoral response against HIV. 
  • Toll-like receptor 7/8 (TLR7/8) and TLR9 agonists cooperate to enhance HIV-1 envelope antibody responses in rhesus macaques. 
  • Topology links RNA secondary structure with global conformation, dynamics, and adaptation. 
  • Total chemical synthesis and biophysical characterization of the minimal isoform of the KChIP2 potassium channel regulatory subunit. 
  • Translating antibody-binding peptides into peptoid ligands with improved affinity and stability. 
  • Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures. 
  • Tunable leuko-polymersomes that adhere specifically to inflammatory markers. 
  • U1 RNA induces innate immunity signaling. 
  • Understanding the Contributions of Conformational Changes, Thermodynamics, and Kinetics of RNA-Small Molecule Interactions. 
  • Understanding thrombocytopenia and antigenicity with glycoprotein IIb-IIIa inhibitors. 
  • Universal nomenclature for oxytocin-vasotocin ligand and receptor families. 
  • Unraveling the structural complexity in a single-stranded RNA tail: implications for efficient ligand binding in the prequeuosine riboswitch. 
  • Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice. 
  • Use of multiple radioligands to characterize adenosine receptors in human placenta. 
  • Use of phage display to identify novel mineralocorticoid receptor-interacting proteins. 
  • Use of phosphorus ligand NMR probes to investigate electronic and second-sphere solvent effects in ligand substitution reactions at manganese(II) and manganese(III). 
  • Using Cryo-EM to Map Small Ligands on Dynamic Metabolic Enzymes: Studies with Glutamate Dehydrogenase. 
  • Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2. 
  • Visualization of P-selectin glycoprotein ligand-1 as a highly extended molecule and mapping of protein epitopes for monoclonal antibodies. 
  • Visualizing multistep elevator-like transitions of a nucleoside transporter. 
  • Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. 
  • Wnt Signaling and Drug Resistance in Cancer. 
  • X-ray crystallographic analysis of adipocyte fatty acid binding protein (aP2) modified with 4-hydroxy-2-nonenal. 
  • ZAP-70 tyrosine kinase is required for the up-regulation of Fas ligand in activation-induced T cell apoptosis. 
  • [Receptor-ligand reaction in the central nervous system (principal problems and prospects for development)]. 
  • alpha(1)-adrenergic receptors mediate LH-releasing hormone secretion through phospholipases C and A(2) in immortalized hypothalamic neurons. 
  • beta-Arrestin mediates beta1-adrenergic receptor-epidermal growth factor receptor interaction and downstream signaling. 
  • beta-arrestin-biased agonism at the beta2-adrenergic receptor. 
  • cCXCR1 is a receptor for cIL-8 (9E3/cCAF) and its N- and C-terminal peptides and is also activated by hIL-8 (CXCL8). 
  • p62, A TFIIH subunit, directly interacts with thyroid hormone receptor and enhances T3-mediated transcription. 
  • p75 Is Required for the Establishment of Postnatal Sensory Neuron Diversity by Potentiating Ret Signaling. 
  • {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. 
• 

  Keywords of People

  • Bejsovec, Amy, Associate Professor of Biology, Biology
  • Chitneni, Satish K., Associate Professor in Radiology, Radiology
  • Ciofani, Maria, Associate Professor of Integrative Immunobiology, Cell Biology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Gunn, Michael Dee, Professor of Medicine, Integrative Immunobiology
  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology
  • Oas, Terrence Gilbert, Professor of Biochemistry, Biochemistry
  • Patz Jr., Edward F., James and Alice Chen Distinguished Professor of Radiology, Pathology
  • Taylor, Gregory Alan, Professor in Medicine, Integrative Immunobiology