Lipid Bilayers

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  Subject Areas on Research

  • A facile approach to immobilize protein for biosensor: self-assembled supported bilayer lipid membranes on glassy carbon electrode. 
  • A family of calcium-dependent potassium channels from rat brain. 
  • A new method for studying the interaction between chlorpromazine and phospholipid bilayer. 
  • A new monofluorinated phosphatidylcholine forms interdigitated bilayers. 
  • A novel micropipet method for measuring the bending modulus of vesicle membranes. 
  • A quantitative explanation of the effects of some alcohols on gramicidin single-channel lifetime. 
  • A synthetic mimic of the secretory granule for drug delivery. 
  • Acetylcholine receptors from electroplax membranes: in vitro and in situ properties. 
  • Achieving high permeability and enhanced selectivity for Angstrom-scale separations using artificial water channel membranes. 
  • Activation by odorants of a multistate cation channel from olfactory cilia. 
  • Adhesion between cerebroside bilayers. 
  • Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity. 
  • Alamethicin-induced changes in lipid bilayer morphology. 
  • Aqueous self-assembly of poly(ethylene oxide)-block-poly(ε-caprolactone) (PEO-b-PCL) copolymers: disparate diblock copolymer compositions give rise to nano- and meso-scale bilayered vesicles. 
  • Area per molecule and distribution of water in fully hydrated dilauroylphosphatidylethanolamine bilayers. 
  • Assays to measure plasma membrane and cytoskeletal changes in interferon-treated cells. 
  • Avidin-biotin interactions at vesicle surfaces: adsorption and binding, cross-bridge formation, and lateral interactions. 
  • Bilayer interfacial properties modulate the binding of amphipathic peptides. 
  • Bilayers as protein solvents: role of bilayer structure and elastic properties. 
  • Biomembrane templates for nanoscale conduits and networks. 
  • Biomimetic silica microspheres in biosensing. 
  • CFTR regulation of epithelial sodium channel. 
  • CVD for the facile synthesis of hybrid nanobiomaterials integrating functional supramolecular assemblies. 
  • Calcium channels reconstituted from the skeletal muscle dihydropyridine receptor protein complex and its alpha 1 peptide subunit in lipid bilayers. 
  • Calculation on fluorescence resonance energy transfer on surfaces. 
  • Cell-directed assembly of lipid-silica nanostructures providing extended cell viability. 
  • Characterization and property of DNA incorporated bilayer lipid membranes. 
  • Cholesterol modifies the short-range repulsive interactions between phosphatidylcholine membranes. 
  • Coded aperture Raman spectroscopy for quantitative measurements of ethanol in a tissue phantom. 
  • Combined macro- and microrheometer for use with Langmuir monolayers. 
  • Competitive, reversible inhibition of cytosolic phospholipase A2 at the lipid-water interface by choline derivatives that partially partition into the phospholipid bilayer. 
  • Concentration-dependent behavior of nisin interaction with supported bilayer lipid membrane. 
  • Conformation change of horseradish peroxidase in lipid membrane. 
  • Contributions of hydration and steric (entropic) pressures to the interactions between phosphatidylcholine bilayers: experiments with the subgel phase. 
  • Cytochrome oxidase: structural insights from electron microscopy and from secondary structure prediction. 
  • Depth of water penetration into lipid bilayers. 
  • Design and synthesis of manganese porphyrins with tailored lipophilicity: investigation of redox properties and superoxide dismutase activity. 
  • Detection of membrane biointeractions based on fluorescence superquenching. 
  • Determination of the depth of bromine atoms in bilayers formed from bromolipid probes. 
  • Didodecyldimethylammonium bromide lipid bilayer-protected gold nanoparticles: synthesis, characterization, and self-assembly. 
  • Differences in hydrocarbon chain tilt between hydrated phosphatidylethanolamine and phosphatidylcholine bilayers. A molecular packing model. 
  • Directed self-assembly of monodisperse phospholipid bilayer Nanodiscs with controlled size. 
  • Disc formation in cholesterol-free liposomes during phase transition. 
  • Dual-wavelength ratiometric fluorescence measurement of the membrane dipole potential. 
  • Effect of benzyl alcohol on lipid bilayers. A comparisons of bilayer systems. 
  • Effect of chain length and unsaturation on elasticity of lipid bilayers. 
  • Effect of freeze-thawing on lipid bilayer-protected gold nanoparticles. 
  • Effects of n-alkanes on the morphology of lipid bilayers. A freeze-fracture and negative stain analysis. 
  • Effects of natural and enantiomeric cholesterol on the thermotropic phase behavior and structure of egg sphingomyelin bilayer membranes. 
  • Effects of phenylamide herbicides on the physical properties of phosphatidylcholine membranes. 
  • Elastic deformation and failure of lipid bilayer membranes containing cholesterol. 
  • Elasticity, strength, and water permeability of bilayers that contain raft microdomain-forming lipids. 
  • Electro-mechanical permeabilization of lipid vesicles. Role of membrane tension and compressibility. 
  • Electrochemical study of ion channel behavior in incorporated poly L-glutamate bilayer lipid membranes. 
  • Electron tomography of fiber cell cytoplasm and dense cores of multilamellar bodies from human age-related nuclear cataracts. 
  • Electrostatic and lipid anchor contributions to the interaction of transducin with membranes: mechanistic implications for activation and translocation. 
  • Evidence for the role of cell stiffness in modulation of volume-regulated anion channels. 
  • Exchange of monooleoylphosphatidylcholine as monomer and micelle with membranes containing poly(ethylene glycol)-lipid. 
  • Experimental tests for protrusion and undulation pressures in phospholipid bilayers. 
  • Formation and dynamics of supported phospholipid membranes on a periodic nanotextured substrate. 
  • Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles. 
  • Generation of high curvature membranes mediated by direct endophilin bilayer interactions. 
  • Giant vesicle bilayers composed of mixtures of lipids, cholesterol and polypeptides. Thermomechanical and (mutual) adherence properties. 
  • Growth of cationic lipid toward bilayer lipid membrane by solution spreading: scanning probe microscopy study. 
  • Highly selective water channel activity measured by voltage clamp: analysis of planar lipid bilayers reconstituted with purified AqpZ. 
  • Hydration and steric pressures between phospholipid bilayers. 
  • Hydration force and bilayer deformation: a reevaluation. 
  • Hydration properties of lamellar and non-lamellar phases of phosphatidylcholine and phosphatidylethanolamine. 
  • Imaging microtubules and kinesin decorated microtubules using tapping mode atomic force microscopy in fluids. 
  • Inactivation of the sodium current in squid giant axons by hydrocarbons. 
  • Increased adhesion between neutral lipid bilayers: interbilayer bridges formed by tannic acid. 
  • Influence of cholesterol on water penetration into bilayers. 
  • Influence of lipid composition on physical properties and peg-mediated fusion of curved and uncurved model membrane vesicles: "nature's own" fusogenic lipid bilayer. 
  • Insight into the mechanism of antimicrobial conjugated polyelectrolytes: lipid headgroup charge and membrane fluidity effects. 
  • Insight into the mechanism of antimicrobial poly(phenylene ethynylene) polyelectrolytes: interactions with phosphatidylglycerol lipid membranes. 
  • Interaction of K7Fe3+P2W17O62H2 with supported bilayer lipid membranes on platinum electrode. 
  • Interaction of benzene with bilayers. Thermal and structural studies. 
  • Interaction of halothane with lipid bilayers. 
  • Interactions between charged, uncharged, and zwitterionic bilayers containing phosphatidylglycerol. 
  • Interactions between poly(2-ethylacrylic acid) and lipid bilayer membranes: effects of cholesterol and grafted poly(ethylene glycol). 
  • Interactions of phospholipid bilayer with chitosan: effect of molecular weight and pH. 
  • Interbilayer interactions between sphingomyelin and sphingomyelin/cholesterol bilayers. 
  • Interdigitated hydrocarbon chain packing causes the biphasic transition behavior in lipid/alcohol suspensions. 
  • Ion channel behavior of amphotericin B in sterol-free and cholesterol- or ergosterol-containing supported phosphatidylcholine bilayer model membranes investigated by electrochemistry and spectroscopy. 
  • Ion channel behavior of supported bilayer lipid membranes on a glassy carbon electrode. 
  • Ion-channel sensing of ferricyanide anion based on a supported bilayer lipid membrane. 
  • Jumping to rafts: gatekeeper role of bilayer elasticity. 
  • Lectin and epidermal growth factor domains of P-selectin at physiologic density are the recognition unit for leukocyte binding. 
  • Ligatin: a peripheral membrane protein with covalently bound palmitic acid. 
  • Lipid bilayer and water proton magnetization transfer: effect of cholesterol. 
  • Lipid monolayer states and their relationships to bilayers. 
  • Lipid structures: a brief history of multisomes. 
  • Lipid-coated microgels for the triggered release of doxorubicin. 
  • Lipopolysaccharide bilayer structure: effect of chemotype, core mutations, divalent cations, and temperature. 
  • Lipopolysaccharides in bacterial membranes act like cholesterol in eukaryotic plasma membranes in providing protection against melittin-induced bilayer lysis. 
  • Long- and short-range interactions between phospholipid/ganglioside GM1 bilayers. 
  • Loosely packed self-assembled monolayer of N-hexadecyl-3,6-di(p-mercaptophenylacetylene)carbazole on gold and its application in biomimetic membrane research. 
  • Lysolipid exchange with lipid vesicle membranes. 
  • Lysolipid incorporation in dipalmitoylphosphatidylcholine bilayer membranes enhances the ion permeability and drug release rates at the membrane phase transition. 
  • Magnitude of the solvation pressure depends on dipole potential. 
  • Materials characterization of the low temperature sensitive liposome (LTSL): effects of the lipid composition (lysolipid and DSPE-PEG2000) on the thermal transition and release of doxorubicin. 
  • Measurement of interbilayer adhesion energies. 
  • Mechanical equilibrium of thick, hollow, liquid membrane cylinders. 
  • Melittin-induced bilayer leakage depends on lipid material properties: evidence for toroidal pores. 
  • Membrane fusion promoters and inhibitors have contrasting effects on lipid bilayer structure and undulations. 
  • Membrane-protein structural mapping of chloroplast coupling factor in asolectin vesicles. 
  • Model of creation and evolution of stable electropores for DNA delivery. 
  • Modulation of calcium-activated potassium channels from rat brain by protein kinase A and phosphatase 2A. 
  • Modulation of outer medullary NaCl transport and oxygenation by nitric oxide and superoxide. 
  • Modulation of poly(ethylene glycol)-induced fusion by membrane hydration: importance of interbilayer separation. 
  • Modulation of the binding of signal peptides to lipid bilayers by dipoles near the hydrocarbon-water interface. 
  • Modulation of the interbilayer hydration pressure by the addition of dipoles at the hydrocarbon/water interface. 
  • Molecular mobility on the cell surface. 
  • Morphology of the intermediate stages in the lamellar to hexagonal lipid phase transition. 
  • Multilamellar spherical particles as potential sources of excessive light scattering in human age-related nuclear cataracts. 
  • Nano-C60 cytotoxicity is due to lipid peroxidation. 
  • Nanoporous microbead supported bilayers: stability, physical characterization, and incorporation of functional transmembrane proteins. 
  • Nanoscale neuro-integrative coatings for neural implants. 
  • Near-infrared-emissive polymersomes: self-assembled soft matter for in vivo optical imaging. 
  • Negative-stain electron microscopy of inside-out FtsZ rings reconstituted on artificial membrane tubules show ribbons of protofilaments. 
  • Neutron and X-ray diffraction structural analysis of phosphatidylinositol bilayers. 
  • New structural model for mixed-chain phosphatidylcholine bilayers. 
  • On the localization of ubiquinone in phosphatidylcholine bilayers. 
  • On the structure of the hemocyanin channel in lipid bilayers. 
  • Organization of skin stratum corneum extracellular lamellae: diffraction evidence for asymmetric distribution of cholesterol. 
  • Overview of membrane rafts. 
  • Packing and viscoelasticity of polyunsaturated omega-3 and omega-6 lipid bilayers as seen by (2)H NMR and X-ray diffraction. 
  • Persulfated molecular umbrellas as anti-HIV and anti-HSV agents. 
  • Phase separation in biological membranes: integration of theory and experiment. 
  • Photoinitiated destruction of composite porphyrin-protein polymersomes. 
  • Physical and biological properties of cationic triesters of phosphatidylcholine. 
  • Piezo proteins are pore-forming subunits of mechanically activated channels. 
  • Plasma membrane polarization during mating in yeast cells. 
  • Polyphenols increase adhesion between lipid bilayers by forming interbilayer bridges. 
  • Portable UV-visible spectrometer for measuring absorbance and dichroism of Langmuir monolayers at air-water interfaces. 
  • Probing the ethanol-induced chain interdigitations in gel-state bilayers of mixed-chain phosphatidylcholines. 
  • Protein kinase activity closely associated with a reconstituted calcium-activated potassium channel. 
  • Prothrombin and beta 2-glycoprotein I frequently contribute to antiphospholipid antibody interactions with phospholipids and the generation of abnormal waveform profiles in coagulation assays. 
  • Quantitative optical microscopy and micromanipulation studies on the lipid bilayer membranes of giant unilamellar vesicles. 
  • Range and magnitude of the steric pressure between bilayers containing phospholipids with covalently attached poly(ethylene glycol). 
  • Range of the solvation pressure between lipid membranes: dependence on the packing density of solvent molecules. 
  • Reconstitution of the beta-adrenergic receptor. 
  • Regulation of epithelial chloride channels by protein phosphatase. 
  • Regulation of the beta-adrenergic receptor by methylation of membrane phospholipids. 
  • Repulsive interactions and mechanical stability of polymer-grafted lipid membranes. 
  • Repulsive interactions between uncharged bilayers. Hydration and fluctuation pressures for monoglycerides. 
  • Role of membrane curvature in mechanoelectrical transduction: ion carriers nonactin and valinomycin sense changes in integral bending energy. 
  • Role of the membrane cortex in neutrophil deformation in small pipets. 
  • Role of water in short-range repulsive and attractive interactions between macromolecules and bilayers. 
  • Roles of bilayer material properties in function and distribution of membrane proteins. 
  • Short-range interactions between lipid bilayers measured by X-ray diffraction. 
  • Single-particle cryo-EM structure of a voltage-activated potassium channel in lipid nanodiscs. 
  • Solubility of carbon dioxide in lipid bilayer membranes and organic solvents. 
  • Sorting of lens aquaporins and connexins into raft and nonraft bilayers: role of protein homo-oligomerization. 
  • Sorting of lipids and transmembrane peptides between detergent-soluble bilayers and detergent-resistant rafts. 
  • Stable and fluid multilayer phospholipid-silica thin films: mimicking active multi-lamellar biological assemblies. 
  • Steric repulsion between phosphatidylcholine bilayers. 
  • Structural and functional characterization of the purified cardiac ryanodine receptor-Ca2+ release channel complex. 
  • Structure and cohesive properties of sphingomyelin/cholesterol bilayers. 
  • Structure and interactive properties of highly fluorinated phospholipid bilayers. 
  • Structure and mechanical properties of giant lipid (DMPC) vesicle bilayers from 20 degrees C below to 10 degrees C above the liquid crystal-crystalline phase transition at 24 degrees C. 
  • Structure of the KvAP voltage-dependent K+ channel and its dependence on the lipid membrane. 
  • Structure of the crystalline bilayer in the subgel phase of dipalmitoylphosphatidylglycerol. 
  • Structure of the cytochrome c oxidase dimer. Electron microscopy of two-dimensional crystals. 
  • Structure of the water channel AqpZ from Escherichia coli revealed by electron crystallography. 
  • Structure, composition, and peptide binding properties of detergent soluble bilayers and detergent resistant rafts. 
  • Superquenching as a detector for microsphere-based flow cytometric assays. 
  • Surface ripples cause the large fluid spaces between gel phase bilayers containing small amounts of cholesterol. 
  • Synthesis and characterization of carbohydrate-based phospholipids. 
  • Synthesis, structure, and thermal properties of 1,2-dipalmitoylgalloylglycerol (DPGG), a novel self-adhering lipid. 
  • Temperature dependence of the repulsive pressure between phosphatidylcholine bilayers. 
  • Tension-stabilized pores in giant vesicles: determination of pore size and pore line tension. 
  • Tensions and free energies of formation of "solventless" lipid bilayers. Measurement of high contact angles. 
  • The 2004 Biophysical Society-Avanti Award in Lipids address: roles of bilayer structure and elastic properties in peptide localization in membranes. 
  • The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors. 
  • The dielectric constant of phospholipid bilayers and the permeability of membranes to ions. 
  • The effect of ethanol on the phase transition temperature and the phase structure of monounsaturated phosphatidylcholines. 
  • The effect of phloretin on the hydration of egg phosphatidylcholine multilayers. 
  • The effects of bilayer thickness and tension on gramicidin single-channel lifetime. 
  • The effects of lipid composition on the binding of lasalocid A to small unilamellar vesicles. 
  • The electrical conductivity of phospholipid films as an iodine-sensing mechanism. 
  • The energetics of binding of a signal peptide to lipid bilayers: the role of bilayer properties. 
  • The hydration pressure between lipid bilayers. Comparison of measurements using x-ray diffraction and calorimetry. 
  • The interaction of polyphenols with bilayers: conditions for increasing bilayer adhesion. 
  • The lipopolysaccharide barrier: correlation of antibiotic susceptibility with antibiotic permeability and fluorescent probe binding kinetics. 
  • The straight and curved conformation of FtsZ protofilaments-evidence for rapid exchange of GTP into the curved protofilament. 
  • The water permeability of lens aquaporin-0 depends on its lipid bilayer environment. 
  • Thermomechanical and transition properties of dimyristoylphosphatidylcholine/cholesterol bilayers. 
  • Transbilayer peptide sorting between raft and nonraft bilayers: comparisons of detergent extraction and confocal microscopy. 
  • Tris buffer causes acyl chain interdigitation in phosphatidylglycerol. 
  • Using bicellar mixtures to form supported and suspended lipid bilayers on silicon chips. 
  • Using fluorine nuclear magnetic resonance to probe changes in the structure and dynamics of membrane-active peptides interacting with lipid bilayers. 
  • Using fluorine nuclear magnetic resonance to probe the interaction of membrane-active peptides with the lipid bilayer. 
  • Voltage-gated ion channels in nociceptors: modulation by cGMP. 
  • Water permeability and mechanical strength of polyunsaturated lipid bilayers. 
  • X-ray diffraction to determine the thickness of raft and nonraft bilayers. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor of Cell Biology, Cell Biology
  • Neu, Wanda Krassowska, Professor Emeritus of Biomedical Engineering, Biomedical Engineering