Lipopolysaccharides

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  Subject Areas on Research

  • "Low-level" carbon monoxide administration may carry risk. 
  • A behavioural characterization of neonatal infection-facilitated memory impairment in adult rats. 
  • A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone. 
  • A mouse macrophage lipidome. 
  • A noncanonical function of cGAMP in inflammasome priming and activation. 
  • A novel TLR4-mediated signaling pathway leading to IL-6 responses in human bladder epithelial cells. 
  • A novel mouse model of depletion of stellate cells clarifies their role in ischemia/reperfusion- and endotoxin-induced acute liver injury. 
  • A quantitative analysis of C3 binding to O-antigen capsule, lipopolysaccharide, and outer membrane protein of E. coli 0111B4. 
  • A selective inhibitor of cyclooxygenase-2 reverses endotoxin-induced pyretic responses in non-human primates. 
  • A subset of human monocyte-derived dendritic cells expresses high levels of interleukin-12 in response to combined CD40 ligand and interferon-gamma treatment. 
  • A20 protects mice from D-galactosamine/lipopolysaccharide acute toxic lethal hepatitis. 
  • A20 protects mice from lethal liver ischemia/reperfusion injury by increasing peroxisome proliferator-activated receptor-alpha expression. 
  • Ablation of c-FLIP in hepatocytes enhances death-receptor mediated apoptosis and toxic liver injury in vivo. 
  • Abnormal production of interleukin-1 by microglia from trisomy 16 mice. 
  • Abrogation of α-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats. 
  • Activated T lymphocytes regulate hyaluronan binding to monocyte CD44 via production of IL-2 and IFN-gamma. 
  • Activation of complement by endotoxin. 
  • Activation of src-family tyrosine kinases by LPS regulates cytokine production in dendritic cells by controlling AP-1 formation. 
  • Active immunotherapy for TNF-mediated inflammation using self-assembled peptide nanofibers. 
  • Aging and dietary modulation of elastase and interleukin-1 beta secretion. 
  • Airway inflammation and responsiveness in prostaglandin H synthase-deficient mice exposed to bacterial lipopolysaccharide. 
  • Allogeneic splenocyte transfer and lipopolysaccharide inhalations induce differential T cell expansion and lung injury: a novel model of pulmonary graft-versus-host disease. 
  • Alloimmune lung injury induced by local innate immune activation through inhaled lipopolysaccharide. 
  • Alpha 2 macroglobulin-proteinase complexes stimulate prostaglandin E2 synthesis by peritoneal macrophages. 
  • Alveolar macrophages from overweight/obese subjects with asthma demonstrate a proinflammatory phenotype. 
  • An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice. 
  • Angiogenic growth factors in the pathophysiology of a murine model of acute lung injury. 
  • Anti-inflammatory effects of progesterone in lipopolysaccharide-stimulated BV-2 microglia. 
  • Apolipoprotein E acts to increase nitric oxide production in macrophages by stimulating arginine transport. 
  • Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response. 
  • Apolipoprotein E suppresses glial cell secretion of TNF alpha. 
  • Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis. 
  • Aspirin inhibits tumor necrosis factoralpha gene expression in murine tissue macrophages. 
  • Bacterial DNA induces murine interferon-gamma production by stimulation of interleukin-12 and tumor necrosis factor-alpha. 
  • Bacterial surface association of heat-labile enterotoxin through lipopolysaccharide after secretion via the general secretory pathway. 
  • Behçet's disease patients present high levels of deglycosylated anti-lipoteichoic acid IgG and high IL-8 production after lipoteichoic acid stimulation. 
  • Beta-arrestin-2 regulates the development of allergic asthma. 
  • Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. 
  • Blockade of tissue factor-factor X binding attenuates sepsis-induced respiratory and renal failure. 
  • Bone marrow chimeras and c-fms conditional ablation (Mafia) mice reveal an essential role for resident myeloid cells in lipopolysaccharide/TLR4-induced corneal inflammation. 
  • Both systemic and local lipopolysaccharide (LPS) burden are associated with knee OA severity and inflammation. 
  • Brief Glutamine Pretreatment Increases Alveolar Macrophage CD163/Heme Oxygenase-1/p38-MAPK Dephosphorylation Pathway and Decreases Capillary Damage but Not Neutrophil Recruitment in IL-1/LPS-Insufflated Rats. 
  • C3b binding, but not its breakdown, is affected by the structure of the O-antigen polysaccharide in lipopolysaccharide from Salmonellae. 
  • C3b generation is affected by the structure of the O-antigen polysaccharide in lipopolysaccharide from salmonellae. 
  • C5a induction of human interleukin 1. Synergistic effect with endotoxin or interferon-gamma. 
  • CD14-dependent mechanism for endotoxin-mediated nitric oxide synthesis in murine macrophages. 
  • CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes. 
  • CD40L expression in plasma of volunteers following LPS administration: A comparison between assay of CD40L on platelet microvesicles and soluble CD40L. 
  • CD7 and CD28 are required for murine CD4+CD25+ regulatory T cell homeostasis and prevention of thyroiditis. 
  • CD83 influences cell-surface MHC class II expression on B cells and other antigen-presenting cells. 
  • Caenorhabditis elegans innate immune response triggered by Salmonella enterica requires intact LPS and is mediated by a MAPK signaling pathway. 
  • Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses. 
  • Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells. 
  • Characterization of diffusing capacity and perfusion of the rat lung in a lipopolysaccaride disease model using hyperpolarized 129Xe. 
  • Characterization of interleukin-1 production by microglia in culture. 
  • Characterization of short range DNA looping in endotoxin-mediated transcription of the murine inducible nitric-oxide synthase (iNOS) gene. 
  • Characterization of the effects of endotoxin on macrophage tumor cell killing. 
  • Chondroitin sulphate inhibits NF-κB activity induced by interaction of pathogenic and damage associated molecules. 
  • Chronic lymphocytic leukemia and regulatory B cells share IL-10 competence and immunosuppressive function. 
  • Clara cell secretory protein-deficient mice differ from wild-type mice in inflammatory chemokine expression to oxygen and ozone, but not to endotoxin. 
  • Clara cells attenuate the inflammatory response through regulation of macrophage behavior. 
  • Cloning of mitogen- and antigen-reactive B lymphocytes on filter paper discs. I. A description of the technique and of methods for the analysis of colonies. 
  • Cloning of mitogen- and antigen-reactive B lymphocytes on filter paper discs. II. Paratope frequencies within the mitogen-selected repertoire. 
  • Co-regulation of nuclear respiratory factor-1 by NFkappaB and CREB links LPS-induced inflammation to mitochondrial biogenesis. 
  • Combining lung-protective strategies in experimental acute lung injury: The impact of high-frequency partial liquid ventilation. 
  • Complement and bacteria: chemistry and biology in host defense. 
  • Complement levels and activity in the normal and LPS-injured lung. 
  • Complex pattern of interaction between in utero hypoxia-ischemia and intra-amniotic inflammation disrupts brain development and motor function. 
  • Context-dependent activation kinetics elicited by soluble versus outer membrane vesicle-associated heat-labile enterotoxin. 
  • Cutting edge: Role of osteopontin and integrin αv in T cell-mediated anti-inflammatory responses in endotoxemia. 
  • Cyclic AMP modulates the functional plasticity of immature dendritic cells by inhibiting Src-like kinases through protein kinase A-mediated signaling. 
  • Cyclosporine inhibition of CH series murine B-cell lymphomas. 
  • Cyclosporine inhibition of a murine B cell lymphoma. 
  • Cytokine induction of the ability of human monocyte CD44 to bind hyaluronan is mediated primarily by TNF-alpha and is inhibited by IL-4 and IL-13. 
  • Cytokine production induced by Mycobacterium tuberculosis lipoarabinomannan. Relationship to chemical structure. 
  • Cytokines, leptin, and stress-induced thymic atrophy. 
  • DNA and immunoglobulin synthesis by rabbit peripheral blood lymphocytes in vitro: complete and incomplete stimulation. 
  • Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility. 
  • Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii. 
  • Differential Killing of Salmonella enterica Serovar Typhi by Antibodies Targeting Vi and Lipopolysaccharide O:9 Antigen. 
  • Differential anti-inflammatory effects of LPS in susceptible and resistant mouse strains. 
  • Differential expression of intracellular and secreted osteopontin isoforms by murine macrophages in response to toll-like receptor agonists. 
  • Differential gene expression of interleukin-1 receptor associated kinase-1 and interleukin-1 receptor associated kinase-M in peripheral blood mononuclear cells of young and aged rats following preconditioning with endotoxin. 
  • Differential inhibition of human immunodeficiency virus type 1 in peripheral blood mononuclear cells and TZM-bl cells by endotoxin-mediated chemokine and gamma interferon production. 
  • Discrete and complementary mechanisms of protection of beta-cells against cytokine-induced and oxidative damage achieved by bcl-2 overexpression and a cytokine selection strategy. 
  • Does lipopolysaccharide-mediated inflammation have a role in OA? 
  • Duration and intensity of NF-kappaB activity determine the severity of endotoxin-induced acute lung injury. 
  • Effect of Multi Drug Resistance Protein 4 (MRP4) Inhibition on the Pharmacokinetics and Pharmacodynamics of Ciprofloxacin in Normal and Rats with LPS-Induced Inflammation. 
  • Effect of lipopolysaccharide administration on the number, phenotype and content of nuclear molecules in blood microparticles of normal human subjects. 
  • Effects of 540C91 [(E)-3-[2-(4'-pyridyl)-vinyl]-1H-indole], an inhibitor of hepatic tryptophan dioxygenase, on brain quinolinic acid in mice. 
  • Effects of bacterial lipopolysaccharide on the hydrolysis of phosphatidylinositol-4,5-bisphosphate in murine peritoneal macrophages. 
  • Effects of oxidized LDL on mononuclear phagocytes: inhibition of induction of four inflammatory cytokine gene RNAs, release of NO, and cytolysis of tumor cells. 
  • Elicitation of epithelial cell-derived immune effectors by outer membrane vesicles of nontypeable Haemophilus influenzae. 
  • Endogenous apolipoprotein E suppresses LPS-stimulated microglial nitric oxide production. 
  • Endotoxemia associated with the Jarisch-Herxheimer reaction. 
  • Endotoxin (LPS) stimulates in vitro migration of macrophages from LPS-resistant mice but not from LPS-sensitive mice. 
  • Endotoxin and NO induce MIP-1gamma gene transcription in ANA-1 murine macrophages. 
  • Endotoxin stress-response in cardiomyocytes: NF-kappaB activation and tumor necrosis factor-alpha expression. 
  • Endotoxin-induced uveitis in the rat: observations on altered vascular permeability, clinical findings, and histology. 
  • Endotoxin-mediated S-nitrosylation of p50 alters NF-kappa B-dependent gene transcription in ANA-1 murine macrophages. 
  • Endotoxin-mediated nitric oxide synthesis inhibits IL-1beta gene transcription in ANA-1 murine macrophages. 
  • Endotoxin-mediated synthesis of nitric oxide is dependent on Gq protein signal transduction. 
  • Endotoxin-stimulated Rat Hepatic Stellate Cells Induce Autophagy in Hepatocytes as a Survival Mechanism. 
  • Endotoxin-stimulated nitric oxide production inhibits expression of cytochrome c oxidase in ANA-1 murine macrophages. 
  • Enhanced activation of human dendritic cells by inducible CD40 and Toll-like receptor-4 ligation. 
  • Enhanced expression of cytokines and chemokines by blood monocytes to in vitro lipopolysaccharide stimulation are associated with hostility and severity of depressive symptoms in healthy women. 
  • Enhanced interleukin-8 release and gene expression in macrophages after exposure to Mycobacterium tuberculosis and its components. 
  • Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification. 
  • Expression cloning of three Rhizobium leguminosarum lipopolysaccharide core galacturonosyltransferases. 
  • Expression of cytokine mRNA in murine splenic dendritic cells and better induction of T cell-derived cytokines by dendritic cells than by macrophages during in vitro costimulation assay using specific antigens. 
  • Extended in vivo pharmacodynamic activity of E5564 in normal volunteers with experimental endotoxemia [corrected]. 
  • Extrinsic coagulation blockade attenuates lung injury and proinflammatory cytokine release after intratracheal lipopolysaccharide. 
  • Failure of TLR4-driven NF-kappa B activation to stimulate virus replication in models of HIV type 1 activation. 
  • Fatty liver vulnerability to endotoxin-induced damage despite NF-kappaB induction and inhibited caspase 3 activation. 
  • Full Spectrum of LPS Activation in Alveolar Macrophages of Healthy Volunteers by Whole Transcriptomic Profiling. 
  • Functional Toll-like receptor 4 mutations modulate the response to fibrinogen. 
  • Functional alterations of macrophages in autoimmune MRL-lpr/lpr mice. 
  • Further characterization of a factor from endotoxin-treated serum which releases histamine and heparin from mast cells. 
  • GPI-defective monocytes from paroxysmal nocturnal hemoglobinuria patients show impaired in vitro dendritic cell differentiation. 
  • Gene expression profiles of RAW264.7 macrophages stimulated with preparations of LPS differing in isolation and purity. 
  • Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. 
  • Generation of a fibroblast chemotactic factor in serum by activation of complement. 
  • Generation of a microglial developmental index in mice and in humans reveals a sex difference in maturation and immune reactivity. 
  • Genetic control of peripheral leukocyte response to endotoxin in mice. 
  • Genotypic analysis of B cell colonies by in situ hybridization. Stoichiometric expression of three VH families in adult C57BL/6 and BALB/c mice. 
  • Glutamine attenuates endotoxin-induced lung metabolic dysfunction: potential role of enhanced heat shock protein 70. 
  • Glutamine attenuates tumor necrosis factor-alpha release and enhances heat shock protein 72 in human peripheral blood mononuclear cells. 
  • Glutamine in acute lung injury: the experimental model matters. 
  • Glutamine induces heat shock protein and protects against endotoxin shock in the rat. 
  • Glutamine reduces cytokine release, organ damage, and mortality in a rat model of endotoxemia. 
  • Glycolysis-dependent histone deacetylase 4 degradation regulates inflammatory cytokine production. 
  • Gonococcal lipooligosaccharide suppresses HIV infection in human primary macrophages through induction of innate immunity. 
  • Got worms? Perinatal exposure to helminths prevents persistent immune sensitization and cognitive dysfunction induced by early-life infection. 
  • Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS. 
  • Heat-labile enterotoxin: beyond G(m1) binding. 
  • Hemoglobin induction in mouse macrophages. 
  • Hepatic enrichment and activation of myeloid dendritic cells during chronic hepatitis C virus infection. 
  • Hexa-acylated lipid A is required for host inflammatory response to Neisseria gonorrhoeae in experimental gonorrhea. 
  • Host defense against bacterial endotoxemia-contribution of the early and late components of complement to detoxification. 
  • Human apoE3 but not apoE4 rescues impaired astrocyte activation in apoE null mice. 
  • Human mononuclear phagocyte inducible nitric oxide synthase (iNOS): analysis of iNOS mRNA, iNOS protein, biopterin, and nitric oxide production by blood monocytes and peritoneal macrophages. 
  • Humoral autoimmunity to basement membrane antigens is regulated in C57BL/6 and MRL/MpJ mice transgenic for anti-laminin Ig receptors. 
  • Humoral immune responses in L-selectin-deficient mice. 
  • Hyaluronan fragments contribute to the ozone-primed immune response to lipopolysaccharide. 
  • Identification of S-nitrosylated proteins in endotoxin-stimulated RAW264.7 murine macrophages. 
  • Identification of a lipopolysaccharide binding domain in CD14 between amino acids 57 and 64. 
  • Identification of a novel GTPase, the inducibly expressed GTPase, that accumulates in response to interferon gamma. 
  • Identification of novel innate immune genes by transcriptional profiling of macrophages stimulated with TLR ligands. 
  • Immunologic consequences of acute ethanol ingestion in rats. 
  • In vivo cytokine-associated responses to biomaterials. 
  • In vivo modulation of macrophage tumoricidal activity: enhanced tumor cell killing by peritoneal macrophages from mice given injections of sodium periodate. 
  • Increased coagulation and suppressed generation of activated protein C in aged mice during intra-abdominal sepsis. 
  • Increased gut microbial translocation in HIV-infected children persists in virologic responders and virologic failures after antiretroviral therapy. 
  • Increases in stimulated secretion of proinflammatory cytokines by blood monocytes following arousal of negative affect: the role of insulin resistance as moderator. 
  • Increasing the intracellular Na+ concentration induces differentiation in a pre-B lymphocyte cell line. 
  • Inducible nitric oxide synthase expression by peritoneal macrophages in endometriosis-associated infertility. 
  • Induction of ferritin and heme oxygenase-1 by endotoxin in the lung. 
  • Induction of human dendritic cell maturation using transfection with RNA encoding a dominant positive toll-like receptor 4. 
  • Induction of immune activation by a novel immunomodulatory oligonucleotide without thymocyte apoptosis. 
  • Induction of superoxide anion and nitric oxide production in cultured microglia. 
  • Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins. 
  • Inhibition of LPS toxicity for macrophages by metallothionein-inducing agents. 
  • Inhibition of murine macrophage nitric oxide production by synthetic oligonucleotides. 
  • Inhibition of tumor necrosis factor release from cultured rat Kupffer cells by agents that reduce graft failure from storage injury. 
  • Inhibitor-kappaB kinase-beta regulates LPS-induced TNF-alpha production in cardiac myocytes through modulation of NF-kappaB p65 subunit phosphorylation. 
  • Innate immune activation potentiates alloimmune lung disease independent of chemokine (C-X-C motif) receptor 3. 
  • Intact nitric oxide synthase II gene is required for interferon-beta-mediated suppression of growth and metastasis of pancreatic adenocarcinoma. 
  • Interaction of TLR2 and TLR4 ligands with the N-terminal domain of Gp96 amplifies innate and adaptive immune responses. 
  • Interaction of complex polysaccharides with the complement system: effect of calcium depletion on terminal component consumption. 
  • Interactions of the classical and alternate complement pathway with endotoxin lipopolysaccharide. Effect on platelets and blood coagulation. 
  • Interactions of the complement system with endotoxic lipopolysaccharide. Generation of a factor chemotactic for polymorphonuclear leukocytes. 
  • Interactions of the complement system with endotoxic lipopolysaccharides in immunoglobulin-deficient sera. 
  • Intestinal Alkaline Phosphatase Attenuates Alcohol-Induced Hepatosteatosis in Mice. 
  • Intestinal alkaline phosphatase prevents metabolic syndrome in mice. 
  • Ion fluxes and differentiation in transformed cell lines. 
  • Kdo hydroxylase is an inner core assembly enzyme in the Ko-containing lipopolysaccharide biosynthesis. 
  • Keratocan and lumican regulate neutrophil infiltration and corneal clarity in lipopolysaccharide-induced keratitis by direct interaction with CXCL1. 
  • Ketamine potentiates oxidative stress and influences behavior and inflammation in response to lipolysaccharide (LPS) exposure in early life. 
  • Kilohertz frequency nerve block enhances anti-inflammatory effects of vagus nerve stimulation. 
  • Kinetic analysis of chemotactic factor generation in human serum via activation of the classical and alternate complement pathways. 
  • LPS elicits a much larger and broader inflammatory response than Escherichia coli infection within the hippocampus of neonatal rats. 
  • LPS-sensory peptide communication in experimental cystitis. 
  • Labeling of peripheral blood polymorphonuclear leukocytes with indium-111: a new method for the quantitation of in-vivo accumulation of PMNLs in rabbit skin. 
  • Leptin receptor is expressed in thymus medulla and leptin protects against thymic remodeling during endotoxemia-induced thymus involution. 
  • Leptin regulates proinflammatory immune responses. 
  • Leptin selectively augments thymopoiesis in leptin deficiency and lipopolysaccharide-induced thymic atrophy. 
  • Leukemia inhibitory factor is a mediator of Escherichia coli lipopolysaccharide-induced acute thymic atrophy. 
  • Leukocyte-derived IL-10 reduces subepithelial fibrosis associated with chronically inhaled endotoxin. 
  • Lipooligosaccharide is required for the generation of infectious elementary bodies in Chlamydia trachomatis. 
  • Lipopolysaccharide 3-deoxy-D-manno-octulosonic acid (Kdo) core determines bacterial association of secreted toxins. 
  • Lipopolysaccharide and phorbol esters induce differentiation but have opposite effects on phosphatidylinositol turnover and Ca2+ mobilization in 70Z/3 pre-B lymphocytes. 
  • Lipopolysaccharide and soluble CD14 in cord blood plasma are associated with prematurity and chorioamnionitis. 
  • Lipopolysaccharide bilayer structure: effect of chemotype, core mutations, divalent cations, and temperature. 
  • Lipopolysaccharide facilitates partner preference behaviors in female prairie voles. 
  • Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis. 
  • Lipopolysaccharide stimulates mitochondrial biogenesis via activation of nuclear respiratory factor-1. 
  • Lipopolysaccharide up-regulates platelet-derived growth factor (PDGF) alpha-receptor expression in rat lung myofibroblasts and enhances response to all PDGF isoforms. 
  • Lipopolysaccharide-induced expression of TRAIL promotes dendritic cell differentiation. 
  • Lipopolysaccharides in bacterial membranes act like cholesterol in eukaryotic plasma membranes in providing protection against melittin-induced bilayer lysis. 
  • Lung inflammation stalls Th17-cell migration en route to the central nervous system during the development of experimental autoimmune encephalomyelitis. 
  • Lymphangitis after self-administration of lipopolysaccharide. 
  • Lymphoma models for B cell activation and tolerance. V. Anti-Ig mediated growth inhibition is reversed by phorbol myristate acetate but does not involve changes in cytosolic free calcium. 
  • Macrophage activation downregulates the degradative capacity of the phagosome. 
  • Macrophage polykaryon formation in vitro by peritoneal cells from mice given injections of sodium periodate. 
  • Mechanism of bacterial resistance to complement-mediated killing: inserted C5b-9 correlates with killing for Escherichia coli O111B4 varying in O-antigen capsule and O-polysaccharide coverage of lipid A core oligosaccharide. 
  • Mechanism of immune response during immunotherapy. 
  • Mechanisms of polyclonal B-cell activation in autoimmune B6-lpr/lpr mice. 
  • Melatonin regulates energy balance and attenuates fever in Siberian hamsters. 
  • Mesenchymal stem cells stimulate protective genetic reprogramming of injured cardiac ventricular myocytes. 
  • Methylene blue reverses endotoxin-induced hypotension. 
  • Microglia and memory: modulation by early-life infection. 
  • Microglial function in human APOE3 and APOE4 transgenic mice: altered arginine transport. 
  • Microtubule acetylation amplifies p38 kinase signalling and anti-inflammatory IL-10 production. 
  • Modulation of lymphocyte functions by group A streptococcal membrane. 
  • Modulation of the tumoricidal function of activated macrophages by bacterial endotoxin and mammalian macrophage activation factor (s). 
  • Monocyte chemoattractant protein-1 is sufficient for the chemotaxis of monocytes and lymphocytes in transgenic mice but requires an additional stimulus for inflammatory activation. 
  • Mutants resistant to LpxC inhibitors by rebalancing cellular homeostasis. 
  • NF-kappaB factors are essential, but not the switch, for pathogen-related induction of the bovine beta-defensin 5-encoding gene in mammary epithelial cells. 
  • NF-κB- and AP-1-mediated DNA looping regulates osteopontin transcription in endotoxin-stimulated murine macrophages. 
  • NOS2 regulation of LPS-induced airway inflammation via S-nitrosylation of NF-{kappa}B p65. 
  • Natural IgM Switches the Function of Lipopolysaccharide-Activated Murine Bone Marrow-Derived Dendritic Cells to a Regulatory Dendritic Cell That Suppresses Innate Inflammation. 
  • Naturally produced outer membrane vesicles from Pseudomonas aeruginosa elicit a potent innate immune response via combined sensing of both lipopolysaccharide and protein components. 
  • Nitric oxide inhibits expression of cytochrome B in endotoxin-stimulated murine macrophages. 
  • Nitric oxide is necessary for CC-class chemokine expression in endotoxin-stimulated ANA-1 murine macrophages. 
  • Nitric oxide mediates relative airway hyporesponsiveness to lipopolysaccharide in surfactant protein A-deficient mice. 
  • Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways. 
  • Nitric oxide-dependent ribosomal RNA cleavage is associated with inhibition of ribosomal peptidyl transferase activity in ANA-1 murine macrophages. 
  • Non-erythroid effects of erythropoietin. 
  • Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis. 
  • Novel tricyclic inhibitors of IkappaB kinase. 
  • Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis. 
  • Ocular albumin fluorophotometric quantitation of endotoxin-induced vascular permeability. 
  • Osteopontin and protein kinase C regulate PDLIM2 activation and STAT1 ubiquitination in LPS-treated murine macrophages. 
  • Osteopontin induces ubiquitin-dependent degradation of STAT1 in RAW264.7 murine macrophages. 
  • Osteopontin is a negative feedback regulator of nitric oxide synthesis in murine macrophages. 
  • Outer Membrane Vesicle Production Facilitates LPS Remodeling and Outer Membrane Maintenance in Salmonella during Environmental Transitions. 
  • Outer membrane protein I of Pseudomonas aeruginosa is a target of cationic antimicrobial peptide/protein. 
  • Oxidized low density lipoprotein suppresses activation of NF kappa B in macrophages via a pertussis toxin-sensitive signaling mechanism. 
  • Ozone primes alveolar macrophage-derived innate immunity in healthy human subjects. 
  • P- and L-selectin mediate distinct but overlapping functions in endotoxin-induced leukocyte-endothelial interactions in the rat mesenteric microcirculation. 
  • PECAM-1 dampens cytokine levels during LPS-induced endotoxemia by regulating leukocyte trafficking. 
  • Periodic, partial inhibition of IkappaB Kinase beta-mediated signaling yields therapeutic benefit in preclinical models of rheumatoid arthritis. 
  • Periodontal disease: a model for the study of inflammation. 
  • Peroxisome proliferator-activated receptor gamma negatively regulates IFN-beta production in Toll-like receptor (TLR) 3- and TLR4-stimulated macrophages by preventing interferon regulatory factor 3 binding to the IFN-beta promoter. 
  • Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis. 
  • Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production. 
  • Pharmacokinetic-pharmacodynamic modeling of apratastat: a population-based approach. 
  • Phorbol esters induce differentiation in a pre-B-lymphocyte cell line by enhancing Na+/H+ exchange. 
  • Pivotal advance: inhibition of HMGB1 nuclear translocation as a mechanism for the anti-rheumatic effects of gold sodium thiomalate. 
  • Plasma biomarkers in a mouse model of preterm labor. 
  • Platelet procoagulant complex assembly in a tissue factor-initiated system. 
  • Polarized monocyte response to cytokine stimulation. 
  • Post-transcriptional inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase by Gö6976 in murine microglia. 
  • Postlipopolysaccharide oxidative damage of mitochondrial DNA. 
  • Preparation and preclinical evaluation of a novel liposomal complete-core lipopolysaccharide vaccine. 
  • Prevention of acute lung injury in swine: depletion of pulmonary intravascular macrophages using liposomal clodronate. 
  • Prolonged neuroinflammation after lipopolysaccharide exposure in aged rats. 
  • Protease production by cultured microglia: substrate gel analysis and immobilized matrix degradation. 
  • Protease-degradable PEG-maleimide coating with on-demand release of IL-1Ra to improve tissue response to neural electrodes. 
  • Proteomic analysis of human bronchoalveolar lavage fluid after subsgemental exposure. 
  • Quantification of mouse macrophage chemotaxis in vitro: role of C5 for the production of chemotactic activity. 
  • Recruited exudative macrophages selectively produce CXCL10 after noninfectious lung injury. 
  • Reduced peripheral PGE2 biosynthesis in Plasmodium falciparum malaria occurs through hemozoin-induced suppression of blood mononuclear cell cyclooxygenase-2 gene expression via an interleukin-10-independent mechanism. 
  • Reduced stress defense in heme oxygenase 1-deficient cells. 
  • Reduction of cardiomyocyte S-nitrosylation by S-nitrosoglutathione reductase protects against sepsis-induced myocardial depression. 
  • Regulation of I-309 gene expression in human monocytes by endogenous interleukin-1. 
  • Regulation of corneal inflammation by neutrophil-dependent cleavage of keratan sulfate proteoglycans as a model for breakdown of the chemokine gradient. 
  • Residues of heat-labile enterotoxin involved in bacterial cell surface binding. 
  • Resistance of CD7-deficient mice to lipopolysaccharide-induced shock syndromes. 
  • Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels. 
  • Resolvin E1 inhibits neuropathic pain and spinal cord microglial activation following peripheral nerve injury. 
  • Retrovirus-elicited interleukin-12 and tumour necrosis factor-alpha as inducers of interferon-gamma-mediated pathology in mouse AIDS. 
  • Role of C-C motif ligand 2 and C-C motif receptor 2 in murine pulmonary graft-versus-host disease after lipopolysaccharide inhalations. 
  • Role of fibrinopeptide B in early atherosclerotic lesion formation. 
  • Role of interleukin-1beta in postoperative cognitive dysfunction. 
  • Role of thromboxane A2 in the induction of apoptosis of immature thymocytes by lipopolysaccharide. 
  • SILAC-MS Based Characterization of LPS and Resveratrol Induced Changes in Adipocyte Proteomics - Resveratrol as Ameliorating Factor on LPS Induced Changes. 
  • SMAD4 is required for development of maximal endotoxin tolerance. 
  • Safety of incremental inhaled lipopolysaccharide challenge in humans. 
  • Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines. 
  • Selective autoregulation of endothelins in primary astrocyte cultures: endothelin receptor-mediated potentiation of endothelin-1 secretion. 
  • Shared monocyte subset phenotypes in HIV-1 infection and in uninfected subjects with acute coronary syndrome. 
  • Short day lengths attenuate the symptoms of infection in Siberian hamsters. 
  • Significance of complement to the mechanism of action of endotoxin. 
  • Skewed VH and V kappa gene family expression and pairing occurs among B lymphocytes in autoimmune motheaten mice. 
  • Social status alters immune regulation and response to infection in macaques. 
  • Soluble CD14 truncated at amino acid 152 binds lipopolysaccharide (LPS) and enables cellular response to LPS. 
  • Sphingosine inhibits monocyte tissue factor-initiated coagulation by altering factor VII binding. 
  • Spontaneous tumor cell killing by human blood monocytes and human peritoneal macrophages: lack of alteration by endotoxin or quenchers of reactive oxygen species. 
  • Statins inhibit toll-like receptor 4-mediated lipopolysaccharide signaling and cytokine expression. 
  • Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA. 
  • Stimulation of ovarian tumor cell proliferation with monocyte products including interleukin-1, interleukin-6, and tumor necrosis factor-alpha. 
  • Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice. 
  • Structure of supported bilayers composed of lipopolysaccharides and bacterial phospholipids: raft formation and implications for bacterial resistance. 
  • Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule. 
  • Substance P and calcitonin gene-related peptide increase IL-1 beta, IL-6 and TNF alpha secretion from human peripheral blood mononuclear cells. 
  • Suppression of lipopolysaccharide-stimulated release of tumor necrosis factor by adenosine: evidence for A2 receptors on rat Kupffer cells. 
  • Surface array proteins of Campylobacter fetus block lectin-mediated binding to type A lipopolysaccharide. 
  • Surfactant protein A integrates activation signal strength to differentially modulate T cell proliferation. 
  • Surfactant protein A modulates induction of regulatory T cells via TGF-β. 
  • Sustenance of endothelial cell stability in septic mice through appropriate activation of transient receptor potential vanilloid-4. 
  • Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of IkappaB kinase. 
  • TLR4-mediated expulsion of bacteria from infected bladder epithelial cells. 
  • TNF, IFN-gamma, and endotoxin increase expression of DMT1 in bronchial epithelial cells. 
  • TT-301 inhibits microglial activation and improves outcome after central nervous system injury in adult mice. 
  • Temporal Patterns in Sheep Fetal Heart Rate Variability Correlate to Systemic Cytokine Inflammatory Response: A Methodological Exploration of Monitoring Potential Using Complex Signals Bioinformatics. 
  • The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation. 
  • The HIV-1 protease inhibitor nelfinavir activates PP2 and inhibits MAPK signaling in macrophages: a pathway to reduce inflammation. 
  • The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia. 
  • The United States National Prospective Hemolytic Uremic Syndrome Study: microbiologic, serologic, clinical, and epidemiologic findings. 
  • The biological activity of a liposomal complete core lipopolysaccharide vaccine. 
  • The critical role of hematopoietic cells in lipopolysaccharide-induced airway inflammation. 
  • The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals. 
  • The effect of active site-inhibited factor VIIa on tissue factor-initiated coagulation using platelets before and after aspirin administration. 
  • The effect of covalently immobilized rhIL-1ra-ELP fusion protein on the inflammatory profile of LPS-stimulated human monocytes. 
  • The effects of CpG DNA on HMGB1 release by murine macrophage cell lines. 
  • The expression of plasma nucleosomes in mice undergoing in vivo apoptosis. 
  • The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens. 
  • The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation. 
  • The immune system and developmental programming of brain and behavior. 
  • The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction. 
  • The indolocarbazole Gö6976 protects neurons from lipopolysaccharide/interferon-gamma-induced cytotoxicity in murine neuron/glia co-cultures. 
  • The influence of lipofectin on the in vitro stimulation of murine spleen cells by bacterial DNA and plasmid DNA vectors. 
  • The linker for activation of B cells (LAB)/non-T cell activation linker (NTAL) regulates triggering receptor expressed on myeloid cells (TREM)-2 signaling and macrophage inflammatory responses independently of the linker for activation of T cells. 
  • The lipopolysaccharide barrier: correlation of antibiotic susceptibility with antibiotic permeability and fluorescent probe binding kinetics. 
  • The necroptosis adaptor RIPK3 promotes injury-induced cytokine expression and tissue repair. 
  • The posterior cricoarytenoid muscle is spared from MuRF1-mediated muscle atrophy in mice with acute lung injury. 
  • The prolyl isomerase Pin1 modulates development of CD8+ cDC in mice. 
  • The properties of microparticles from RAW 264.7 macrophage cells undergoing in vitro activation or apoptosis. 
  • The relation of aggression, hostility, and anger to lipopolysaccharide-stimulated tumor necrosis factor (TNF)-alpha by blood monocytes from normal men. 
  • The relation of severity of depressive symptoms to monocyte-associated proinflammatory cytokines and chemokines in apparently healthy men. 
  • The relationship between apoptosis and high-mobility group protein 1 release from murine macrophages stimulated with lipopolysaccharide or polyinosinic-polycytidylic acid. 
  • The release of microparticles by RAW 264.7 macrophage cells stimulated with TLR ligands. 
  • The role of IFN-alpha and nitric oxide in the release of HMGB1 by RAW 264.7 cells stimulated with polyinosinic-polycytidylic acid or lipopolysaccharide. 
  • The role of Toll-like receptor 4 in environmental airway injury in mice. 
  • The role of ion fluxes in hematopoietic cell differentiation. 
  • The role of the extracellular matrix protein mindin in airway response to environmental airways injury. 
  • The role of tuberous sclerosis complex 1 in regulating innate immunity. 
  • The transcriptomic response of rat hepatic stellate cells to endotoxin: implications for hepatic inflammation and immune regulation. 
  • The upregulation of specific interleukin (IL) receptor antagonists and paradoxical enhancement of neuronal apoptosis due to electrode induced strain and brain micromotion. 
  • Thioredoxin-mediated denitrosylation regulates cytokine-induced nuclear factor κB (NF-κB) activation. 
  • Thrombin enhances monocyte secretion of tumor necrosis factor and interleukin-1 beta by two distinct mechanisms. 
  • Thrombomodulin expression by human blood monocytes and by human synovial tissue lining macrophages. 
  • Time course of LPS-induced gene expression in a mouse model of genitourinary inflammation. 
  • Toll-like receptor 4 (TLR4)-deficient murine macrophage cell line as an in vitro assay system to show TLR4-independent signaling of Bacteroides fragilis lipopolysaccharide. 
  • Toll-like receptor 4 antagonist (E5564) prevents the chronic airway response to inhaled lipopolysaccharide. 
  • Transcriptional regulatory functions of heterogeneous nuclear ribonucleoprotein-U and -A/B in endotoxin-mediated macrophage expression of osteopontin. 
  • Treatment of murine peritoneal macrophages with bacterial lipopolysaccharide alters expression of c-fos and c-myc oncogenes. 
  • Trigeminal c-Fos expression and behavioral responses to pulpal inflammation in ferrets. 
  • Two forms of NF-kappa B1 (p105/p50) in murine macrophages: differential regulation by lipopolysaccharide, interleukin-2, and interferon-gamma. 
  • Tyrosine phosphorylation-independent regulation of lipopolysaccharide-mediated response by the transmembrane adaptor protein LAB. 
  • Variation in DNA and RNA synthetic responses during activation of lymphocytes from inbred strains of mice. 
  • Ventilation defects observed with hyperpolarized 3He magnetic resonance imaging in a mouse model of acute lung injury. 
  • Viral cell death inhibitor MC159 enhances innate immunity against vaccinia virus infection. 
  • Visualization and characterization of inflammatory cell recruitment and migration through the corneal stroma in endotoxin-induced keratitis. 
  • [Effects of intravenous anesthetics on LPS-induced production of tumour necrosis factor-alpha from primary cultures of rat glial cells in vitro]. 
  • [THE ENZYMES OF THE LEUKOCYTE]. 
• 

  Keywords of People

  • Chen, Jun, Associate Professor of Medicine, Duke Cancer Institute
  • Guan, Ziqiang, Research Professor in Biochemistry, Biochemistry
  • Gunn, Michael Dee, Professor of Medicine, Immunology
  • Kelsoe, Garnett H., James B. Duke Professor of Immunology, Immunology
  • Krangel, Michael S., Mary Bernheim Professor of Immunology, Immunology
  • Kuehn, Margarethe Joanna, Associate Professor of Biochemistry, Molecular Genetics and Microbiology
  • Laskowitz, Daniel Todd, Professor of Neurology, Duke Innovation & Entrepreneurship
  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma
  • Pastva, Amy Martha, Assistant Professor in Orthopaedic Surgery, Cell Biology
  • Shinohara, Mari L., Associate Professor of Immunology, Immunology