Cholesterol, HDL

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  Subject Areas on Research

  • A Novel Protein Glycan-Derived Inflammation Biomarker Independently Predicts Cardiovascular Disease and Modifies the Association of HDL Subclasses with Mortality. 
  • A classification system to evaluate weight maintainers, gainers, and losers. 
  • A comparison of methods for the estimation of plasma low- and very low-density lipoprotein cholesterol. The Lipid Research Clinics Prevalence Study. 
  • A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. 
  • A randomized trial of a strategy for increasing high-density lipoprotein cholesterol levels: effects on progression of coronary heart disease and clinical events. 
  • A review of low-carbohydrate ketogenic diets. 
  • A telephone-delivered intervention for patients with NIDDM. Effect on coronary risk factors. 
  • A text messaging-assisted randomized lifestyle weight loss clinical trial among overweight adults in Beijing. 
  • A very low-carbohydrate, low-saturated fat diet for type 2 diabetes management: a randomized trial. 
  • Acute coronary syndromes in deployed military personnel. 
  • Adiposity, cardiometabolic risk, and vitamin D status: the Framingham Heart Study. 
  • Advanced lipoprotein testing does not improve identification of subclinical atherosclerosis in young adults: the Bogalusa Heart Study. 
  • Adverse Cardiovascular Response to Aerobic Exercise Training: Is This a Concern? 
  • Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers. 
  • Adverse metabolic response to regular exercise: is it a rare or common occurrence? 
  • Age and Cardiovascular Risk Attributable to Apolipoprotein B, Low-Density Lipoprotein Cholesterol or Non-High-Density Lipoprotein Cholesterol. 
  • Aggressive lipid lowering in postcoronary angioplasty patients with elevated cholesterol (the Lovastatin Restenosis Trial). 
  • Aggressive treatment of high-density lipoprotein cholesterol. 
  • Alirocumab Reduces Total Hospitalizations and Increases Days Alive and Out of Hospital in the ODYSSEY OUTCOMES Trial. 
  • An adverse lipoprotein phenotype-hypertriglyceridaemic hyperapolipoprotein B-and the long-term risk of type 2 diabetes: a prospective, longitudinal, observational cohort study. 
  • ApoB. 
  • ApoE genotype-specific inhibition of apoptosis. 
  • Are the salutogenic effects of social supports modified by income? A test of an "added value hypothesis". 
  • Assessing the accuracy of a point-of-care analyzer for hyperlipidaemia in western Kenya. 
  • Association Between Skin and Aortic Vascular Inflammation in Patients With Psoriasis: A Case-Cohort Study Using Positron Emission Tomography/Computed Tomography. 
  • Association Between Very Low Levels of High-Density Lipoprotein Cholesterol and Long-term Outcomes of Patients With Acute Coronary Syndrome Treated Without Revascularization: Insights From the TRILOGY ACS Trial. 
  • Association between high-density lipoprotein cholesterol and breast cancer varies by menopausal status. 
  • Association of DASH diet with cardiovascular risk factors in youth with diabetes mellitus: the SEARCH for Diabetes in Youth study. 
  • Association of HIV serostatus and metabolic syndrome with neurobehavioral disturbances. 
  • Association of levels of lipoprotein Lp(a), plasma lipids, and other lipoproteins with coronary artery disease documented by angiography. 
  • Association of lipid profile biomarkers with breast cancer by molecular subtype: analysis of the MEND study. 
  • Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks. 
  • Atenolol induced HDL-C change in the pharmacogenomic evaluation of antihypertensive responses (PEAR) study. 
  • Atherogenic dyslipidemia and residual cardiovascular risk in statin-treated patients. 
  • Baseline blood pressure, low- and high-density lipoproteins, and triglycerides and the risk of vascular events in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial. 
  • Behavioral health mediators of the link between posttraumatic stress disorder and dyslipidemia. 
  • Beneficial effects of pinacidil on blood lipids: comparisons with prazosin and placebo in patients with hypertension. Pinacidil-Prazosin and Pinacidil-Placebo Research Groups, Lilly Research Laboratories. 
  • Beverage Consumption and Longitudinal Changes in Lipoprotein Concentrations and Incident Dyslipidemia in US Adults: The Framingham Heart Study. 
  • Biological, clinical and population relevance of 95 loci for blood lipids. 
  • Caffeine and cholesterol: interactions with hostility. 
  • Can group medical clinics improve lipid management in diabetes? 
  • Carbohydrate restriction is effective in improving atherogenic dyslipidemia even in the absence of weight loss. 
  • Cardio-metabolic risk factors and prehypertension in persons without diabetes, hypertension, and cardiovascular disease. 
  • Cardiometabolic Risks and Severity of Obesity in Children and Young Adults. 
  • Cardiovascular risk factor profiles in familial hypercholesterolemia patients with and without genetic mutation compared to a nationally representative sample of adults in a high-risk European country. 
  • Causal effects of cardiovascular risk factors on onset of major age-related diseases: A time-to-event Mendelian randomization study. 
  • Change in metabolic syndrome parameters with antipsychotic treatment in the CATIE Schizophrenia Trial: prospective data from phase 1. 
  • Changes in serum lipids in patients with condylomata acuminata treated with interferon alfa-n1 (Wellferon). 
  • Characteristics of Framingham offspring participants with long-lived parents. 
  • Cholesterol and cognitive performance among community volunteers from the Czech Republic. 
  • Cholesterol curves to identify population norms by age and sex in healthy weight children. 
  • Cholesterol levels and in-hospital mortality in patients with acute decompensated heart failure. 
  • Clinical reasoning and prevention of cardiovascular disease. 
  • Clinical utility of different lipid measures for prediction of coronary heart disease in men and women. 
  • Clustering of high density lipoprotein cholesterol levels in premenopausal and postmenopausal female twins. 
  • Coconut oil is associated with a beneficial lipid profile in pre-menopausal women in the Philippines. 
  • Combined association of lipids and blood pressure in relation to incident cardiovascular disease in the elderly: the cardiovascular health study. 
  • Common variants associated with plasma triglycerides and risk for coronary artery disease. 
  • Comparison of Nonblood-Based and Blood-Based Total CV Risk Scores in Global Populations. 
  • Comparison of low- and high-carbohydrate diets for type 2 diabetes management: a randomized trial. 
  • Cord blood lipids in infants born to HIV-1-infected women treated with combination antiretroviral therapy. 
  • Correlates of systolic and diastolic blood pressure in men 40 to 59 years of age sampled from United States of America and Union of Soviet Socialist Republics Lipid Research Clinics populations. 
  • Costs of the metabolic syndrome in elderly individuals: findings from the Cardiovascular Health Study. 
  • Dark chocolate effect on platelet activity, C-reactive protein and lipid profile: a pilot study. 
  • Determinants of retinal venular diameter: the Beaver Dam Eye Study. 
  • Dietary fish oil. Influence on lesion regression in the porcine model of atherosclerosis. 
  • Differential association of serum lipids with diabetic retinopathy and diabetic macular edema. 
  • Discordant risk: overweight and cardiometabolic risk in Chinese adults. 
  • Discovery and refinement of loci associated with lipid levels. 
  • Does a high level of HDL-C cholesterol undo the bad effects of a high LDL-C cholesterol? 
  • Dyslipidaemia and microvascular disease in the retina. 
  • Effect of a low-carbohydrate, ketogenic diet program compared to a low-fat diet on fasting lipoprotein subclasses. 
  • Effect of ezetimibe/simvastatin compared with atorvastatin on lipoprotein subclasses in patients with type 2 diabetes and hypercholesterolaemia. 
  • Effect on high-density lipoprotein cholesterol of maximum dose simvastatin and atorvastatin in patients with hypercholesterolemia: results of the Comparative HDL Efficacy and Safety Study (CHESS). 
  • Effectiveness and tolerability of adding ezetimibe to niacin-based regimens for treatment of primary hyperlipidemia. 
  • Effects of Increasing Exercise Intensity and Dose on Multiple Measures of HDL (High-Density Lipoprotein) Function. 
  • Effects of PREMIER lifestyle modifications on participants with and without the metabolic syndrome. 
  • Effects of aerobic training with and without weight loss on insulin sensitivity and lipids. 
  • Effects of combination lipid therapy on coronary stenosis progression and clinical cardiovascular events in coronary disease patients with metabolic syndrome: a combined analysis of the Familial Atherosclerosis Treatment Study (FATS), the HDL-Atherosclerosis Treatment Study (HATS), and the Armed Forces Regression Study (AFREGS). 
  • Effects of exercise training on cardiorespiratory function in men and women older than 60 years of age. 
  • Effects of ezetimibe, simvastatin and ezetimibe/simvastatin on correlations between apolipoprotein B, LDL cholesterol and non-HDL cholesterol in patients with primary hypercholesterolemia. 
  • Effects of low-carbohydrate diets versus low-fat diets on metabolic risk factors: a meta-analysis of randomized controlled clinical trials. 
  • Effects of ocular carteolol and timolol on plasma high-density lipoprotein cholesterol level. 
  • Efficacy and tolerability of lovastatin in 3390 women with moderate hypercholesterolemia. 
  • Endothelial dysfunction and the risk of hypertension: the multi-ethnic study of atherosclerosis. 
  • Evacetrapib and Cardiovascular Outcomes in High-Risk Vascular Disease. 
  • Evaluation of the National Cholesterol Education Program Adult Treatment Panel III algorithm for selecting candidates for statin therapy: insights from the A to Z trial. 
  • Exercise effects on lipids in persons with varying dietary patterns-does diet matter if they exercise? Responses in Studies of a Targeted Risk Reduction Intervention through Defined Exercise I. 
  • Expanded Clinical Evaluation of Lovastatin (EXCEL) study results. Effect of patient characteristics on lovastatin-induced changes in plasma concentrations of lipids and lipoproteins. 
  • Extended-release niacin for modifying the lipoprotein profile. 
  • Extended-release niacin vs gemfibrozil for the treatment of low levels of high-density lipoprotein cholesterol. Niaspan-Gemfibrozil Study Group. 
  • Ezetimibe/simvastatin vs atorvastatin in patients with type 2 diabetes mellitus and hypercholesterolemia: the VYTAL study. 
  • Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial. 
  • Fasting might not be necessary before lipid screening: a nationally representative cross-sectional study. 
  • Frequency of low serum high-density lipoprotein cholesterol levels in hospitalized patients with "desirable" total cholesterol levels. 
  • Gain-of-function lipoprotein lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site. 
  • Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. 
  • Glycated hemoglobin and the risk of kidney disease and retinopathy in adults with and without diabetes. 
  • Glycated hemoglobin measurement and prediction of cardiovascular disease. 
  • Graphical assessment of incremental value of novel markers in prediction models: From statistical to decision analytical perspectives. 
  • HDL-cholesterol levels and risk of age-related macular degeneration: a multiethnic genetic study using Mendelian randomization. 
  • HDL-raising strategies in the treatment of coronary artery disease: perspectives from the Armed Forces Regression Study. 
  • Health disparities among adult patients with a phenotypic diagnosis of familial hypercholesterolemia in the CASCADE-FH™ patient registry. 
  • Heritability estimates of endophenotypes of long and health life: the Long Life Family Study. 
  • Heterogeneity of healthy aging: comparing long-lived families across five healthy aging phenotypes of blood pressure, memory, pulmonary function, grip strength, and metabolism. 
  • High prevalence of low HDL-c in the Philippines compared to the US: population differences in associations with diet and BMI. 
  • High-Density Lipoprotein Cholesterol and All-Cause and Cause-Specific Mortality Among the Elderly. 
  • High-density lipoprotein-cholesterol functionality and metabolic syndrome: Protocol for review and meta-analysis. 
  • High-sensitivity C-reactive protein elevation in patients with prior myocardial infarction in the United States. 
  • Higher high-density lipoprotein cholesterol in African-American women with polycystic ovary syndrome compared with Caucasian counterparts. 
  • Identification and quantification of regioisomeric cholesteryl linoleate hydroperoxides in oxidized human low density lipoprotein and high density lipoprotein. 
  • Impact of gastrectomy on high-density lipoprotein cholesterol elevation in nonobese patients during a 10-year follow-up. 
  • Impact of gene variants on sex-specific regulation of human Scavenger receptor class B type 1 (SR-BI) expression in liver and association with lipid levels in a population-based study. 
  • Impact of increases in high-density lipoprotein cholesterol on cardiovascular outcomes during the armed forces regression study. 
  • Impact of inflammatory biomarkers on relation of high density lipoprotein-cholesterol with incident coronary heart disease: cardiovascular Health Study. 
  • Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls. 
  • Improvement of cardiovascular risk prediction: time to review current knowledge, debates, and fundamentals on how to assess test characteristics. 
  • Interaction Between Peroxisome Proliferator Activated Receptor δ and Epithelial Membrane Protein 2 Polymorphisms Influences HDL-C Levels in the Chinese Population. 
  • Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies and methylation analysis of 3 studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium. 
  • Is a low-carb, low-fat diet optimal? 
  • Is nuclear magnetic resonance lipoprotein subclass related to diabetic retinopathy? The multi-ethnic study of atherosclerosis (MESA). 
  • Lack of effect of lovastatin on restenosis after coronary angioplasty. Lovastatin Restenosis Trial Study Group. 
  • Lifetime risk for developing dyslipidemia: the Framingham Offspring Study. 
  • Lipid changes associated with antiretroviral therapy: results differ by reporting approach. 
  • Lipid levels in patients hospitalized with coronary artery disease: an analysis of 136,905 hospitalizations in Get With The Guidelines. 
  • Lipid-altering efficacy and safety of ezetimibe/simvastatin coadministered with extended-release niacin in patients with type IIa or type IIb hyperlipidemia. 
  • Lipids and lactate in human immunodeficiency virus-1 infected pregnancies with or without protease inhibitor-based therapy. 
  • Lipoprotein response to exercise training and a low-fat diet in older subjects with glucose intolerance. 
  • Long-term efficacy and safety of mipomersen in patients with familial hypercholesterolaemia: 2-year interim results of an open-label extension. 
  • Long-term safety and efficacy of a once-daily niacin/lovastatin formulation for patients with dyslipidemia. 
  • Long-term safety and efficacy of triple combination ezetimibe/simvastatin plus extended-release niacin in patients with hyperlipidemia. 
  • Longitudinal changes in high-density lipoprotein cholesterol and cardiovascular events in older adults. 
  • Lovastatin increases exercise-induced skeletal muscle injury. 
  • Low-density lipoprotein 4: a novel predictor of coronary artery disease severity. 
  • Lymphocyte activation gene-3-associated protein networks are associated with HDL-cholesterol and mortality in the Trans-omics for Precision Medicine program. 
  • Major lipids, apolipoproteins, and risk of vascular disease. 
  • Marginal vitamin B-6 deficiency decreases plasma (n-3) and (n-6) PUFA concentrations in healthy men and women. 
  • Meta-analysis of genome-wide association studies of HDL cholesterol response to statins. 
  • Metabolic abnormalities and cardiovascular disease risk factors in adults with human immunodeficiency virus infection and lipodystrophy. 
  • Metabolic syndrome and risk of age-related cataract over time: an analysis of interval-censored data using a random-effects model. 
  • Metabolic syndrome components and age-related cataract: the Singapore Malay eye study. 
  • Metabolic syndrome, C-reactive protein, and prognosis in patients with established coronary artery disease. 
  • Modification of postprandial hyperglycemia with insulin lispro improves glucose control in patients with type 2 diabetes. 
  • Modification of the effects of estrogen therapy on HDL cholesterol levels by polymorphisms of the HDL-C receptor, SR-BI: the Rancho Bernardo Study. 
  • Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. 
  • Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. 
  • New loci and coding variants confer risk for age-related macular degeneration in East Asians. 
  • Niacin and heart disease prevention: Engraving its tombstone is a mistake. 
  • Night shift work and cardiovascular disease biomarkers in female nurses. 
  • Nonpharmacologic and pharmacologic treatment of patients with low levels of high-density lipoprotein cholesterol. 
  • Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. 
  • Nutrition for the diabetic pregnant woman. 
  • Pathways-driven sparse regression identifies pathways and genes associated with high-density lipoprotein cholesterol in two Asian cohorts. 
  • Periodontitis and multiple markers of cardiometabolic risk in the fourth decade: A cohort study. 
  • Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR. 
  • Plasma fibrinogen levels and their correlates in 6457 coronary heart disease patients. The Bezafibrate Infarction Prevention (BIP) Study. 
  • Polymorphisms of the HDL receptor gene associated with HDL cholesterol levels in diabetic kindred from three populations. 
  • Prevalence of age-related macular degeneration in a Malay population: the Singapore Malay Eye Study. 
  • Prevalence of the metabolic syndrome in patients with schizophrenia: baseline results from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial and comparison with national estimates from NHANES III. 
  • Quantifying Importance of Major Risk Factors for Coronary Heart Disease. 
  • Quantitative and Qualitative Role of Antagonistic Heterogeneity in Genetics of Blood Lipids. 
  • Racial differences in the interaction between family history and risk factors associated with diabetes in the National Health and Nutritional Examination Survey, 1999-2004. 
  • Randomized Evaluation of the Effects of Anacetrapib through Lipid-modification (REVEAL)-A large-scale, randomized, placebo-controlled trial of the clinical effects of anacetrapib among people with established vascular disease: Trial design, recruitment, and baseline characteristics. 
  • Rationale and design of a secondary prevention trial of increasing serum high-density lipoprotein cholesterol and reducing triglycerides in patients with clinically manifest atherosclerotic heart disease (the Bezafibrate Infarction Prevention Trial). 
  • Reduction of atherogenic risk factors by short-term weight reduction. Evidence of the efficacy of National Cholesterol Education Program guidelines for the obese. 
  • Refocusing the AIM on HDL in the metabolic syndrome. 
  • Relation of admission high-density lipoprotein cholesterol level and in-hospital mortality in patients with acute non-ST segment elevation myocardial infarction (from the National Cardiovascular Data Registry). 
  • Relations of GlycA and lipoprotein particle subspecies with cardiovascular events and mortality: A post hoc analysis of the AIM-HIGH trial. 
  • Relations of trait depression and anxiety to low lipid and lipoprotein concentrations in healthy young adult women. 
  • Relationship of lipoproteins to cardiovascular events: the AIM-HIGH Trial (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides and Impact on Global Health Outcomes). 
  • Relative and cumulative effects of lipid and blood pressure control in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels trial. 
  • Response of high-sensitivity C-reactive protein to exercise training in an at-risk population. 
  • Retinal vessel diameters and the incidence of gross proteinuria and renal insufficiency in people with type 1 diabetes. 
  • Risk factors for cardiovascular disease across the spectrum of older age: the Cardiovascular Health Study. 
  • Sensitivity and specificity can change in opposite directions when new predictive markers are added to risk models. 
  • Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies. 
  • Serum Cholesterol Levels within the High Normal Range Are Associated with Better Cognitive Performance among Chinese Elderly. 
  • Serum apolipoprotein AI and B are stronger biomarkers of diabetic retinopathy than traditional lipids. 
  • Serum cholesterol and statin use predict virological response to peginterferon and ribavirin therapy. 
  • Sex Differences in the Association Between Metabolic Dysregulation and Cognitive Aging: The Health and Retirement Study. 
  • Statins for stroke prevention. 
  • Subclinical atherosclerotic cardiovascular disease and early age-related macular degeneration in a multiracial cohort: the Multiethnic Study of Atherosclerosis. 
  • Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations. 
  • Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis. 
  • Targeting cardiovascular risk associated with both low density and high density lipoproteins using statin-niacin combination therapy. 
  • The Association Between Lipoproteins, Disability, and Physical Function Among Older Costa Rican Adults. 
  • The Clinical Antipsychotic Trials Of Intervention Effectiveness (CATIE) Schizophrenia Trial: clinical comparison of subgroups with and without the metabolic syndrome. 
  • The Expected 30-Year Benefits of Early Versus Delayed Primary Prevention of Cardiovascular Disease by Lipid Lowering. 
  • The W64R variant of the beta3-adrenergic receptor is not associated with type II diabetes or obesity in a large Finnish sample. 
  • The adaptor protein beta-arrestin2 enhances endocytosis of the low density lipoprotein receptor. 
  • The association between triglycerides and incident cardiovascular disease: What is "optimal"? 
  • The impact of race on metabolic disease risk factors in women with and without posttraumatic stress disorder. 
  • The influence of statin medications on prostate-specific antigen levels. 
  • The relationship between albuminuria and hypercholesterolemia. 
  • Thrombospondin-4 polymorphism (A387P) predicts cardiovascular risk in postinfarction patients with high HDL cholesterol and C-reactive protein levels. 
  • Trajectories of Non-HDL Cholesterol Across Midlife: Implications for Cardiovascular Prevention. 
  • Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained. 
  • Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition parameters in hypogonadal men. 
  • Two-year trends in physical performance following supervised exercise among community-dwelling older veterans. 
  • U.S.S.R. and U.S. nutrient intake, plasma lipids, and lipoproteins in men ages 40-59 sampled from Lipid Research Clinics populations. 
  • Universal Cholesterol Screening in Childhood: A Systematic Review. 
  • Usefulness of Icosapent Ethyl (Eicosapentaenoic Acid Ethyl Ester) in Women to Lower Triglyceride Levels (Results from the MARINE and ANCHOR Trials). 
  • Vascular age: integrating carotid intima-media thickness measurements with global coronary risk assessment. 
  • Weight-based teasing in youth: Associations with metabolic and inflammatory markers. 
  • Who are the weight maintainers? 
  • [Discriminative ability, reclassification and net benefit: the predictive value of biomarkers]. 
  • [Performance measures for prediction models and markers: evaluation of predictions and classifications]. 
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  Keywords of People

  • O'Connor, Christopher Michael, Adjunct Professor in the Department of Medicine, Medicine, Clinical Pharmacology
  • Yancy Jr., William Samuel, Professor of Medicine, Medicine, General Internal Medicine