Lipoproteins, LDL

• 

  Subject Areas on Research

  • A blood-based biomarker panel to risk-stratify mild traumatic brain injury. 
  • A dietary pattern that lowers oxidative stress increases antibodies to oxidized LDL: results from a randomized controlled feeding study. 
  • A focal stress gradient-dependent mass transfer mechanism for atherogenesis in branching arteries. 
  • A mathematical model for the receptor mediated cellular regulation of the low density lipoprotein metabolism. 
  • A requirement for ankyrin binding to clathrin during coated pit budding. 
  • A serum-free defined culture system which maintains follicle-stimulating hormone responsiveness and differentiation of porcine granulosa cells. 
  • Adrenergic effects on plasma lipoprotein metabolism. Speculation on mechanisms of action. 
  • Advanced glycation end-product of low density lipoprotein activates the toll-like 4 receptor pathway implications for diabetic atherosclerosis. 
  • Altered Maturation Status and Possible Immune Exhaustion of CD8 T Lymphocytes in the Peripheral Blood of Patients Presenting With Acute Coronary Syndromes. 
  • Altered ultrastructural morphology of self-aggregated low density lipoproteins: coalescence of lipid domains forming droplets and vesicles. 
  • An apolipoprotein E-mimetic stimulates axonal regeneration and remyelination after peripheral nerve injury. 
  • Analysis of pleiotropic genetic effects on cognitive impairment, systemic inflammation, and plasma lipids in the Health and Retirement Study. 
  • Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide. 
  • Antibodies of IgM subclass to phosphorylcholine and oxidized LDL are protective factors for atherosclerosis in patients with hypertension. 
  • Antioxidant therapy for atherosclerotic vascular disease: the promise and the pitfalls. 
  • Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology. 
  • Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels. 
  • Atherogenic low density lipoprotein phenotype in long-term survivors of childhood acute lymphoblastic leukemia. 
  • B cell depletion reduces the development of atherosclerosis in mice. 
  • Calcium-activated potassium channels mask vascular dysfunction associated with oxidized LDL exposure in rabbit aorta. 
  • Carbohydrate restriction is effective in improving atherogenic dyslipidemia even in the absence of weight loss. 
  • Changes in lipid profile of patients referred to a cardiac rehabilitation program. 
  • Changes in plasma lipid and lipoprotein levels in men and women after a program of moderate exercise. 
  • Characteristics associated with glycemic control among family medicine patients with type 2 diabetes. 
  • Characterization of sites with elevated LDL permeability at intercostal, celiac, and iliac branches of the normal rabbit aorta. 
  • Clinical relevance of C-reactive protein during follow-up of patients with acute coronary syndromes in the Aggrastat-to-Zocor Trial. 
  • Combination regimens with statin, niacin, and intestinally active LDL-lowering drugs: alternatives to high-dose statin therapy? 
  • Comparison of a reduced carbohydrate and reduced fat diet for LDL, HDL, and VLDL subclasses during 9-months of weight maintenance subsequent to weight loss. 
  • Controlled-release phentermine/topiramate in severely obese adults: a randomized controlled trial (EQUIP). 
  • Cytotoxicity of oxidized LDL to porcine aortic smooth muscle cells is associated with the oxysterols 7-ketocholesterol and 7-hydroxycholesterol. 
  • Decreased membrane complement regulators in the retinal pigmented epithelium contributes to age-related macular degeneration. 
  • Definition of distinct compartments in polarized Madin-Darby canine kidney (MDCK) cells for membrane-volume sorting, polarized sorting and apical recycling. 
  • Differential associations between blood biomarkers of inflammation, oxidation, and lipid metabolism with varying forms of coronary atherosclerotic plaque as quantified by coronary CT angiography. 
  • Differential changes in plasma high-density lipoprotein-cholesterol levels in obese men and women during weight reduction 
  • Diffusion of low density lipoprotein-receptor complex on human fibroblasts. 
  • Effect of actinomycin D on serum betalipoproteins of partially hepatectomized dogs. I. Proteins, lipids, triglycerides and cholesterol. 
  • Effect of actinomycin D on serum betalipoproteins of partially hepatectomized dogs. II - Phospholipids. 
  • Effect of actinomycin D on serum betalipoproteins of partially hepatectomized dogs. III - Fatty acid distribution. 
  • Effect of dietary fat saturation and cholesterol on low density lipoprotein degradation by mononuclear cells of Cebus monkeys. 
  • Effect of exercise and menstrual cycle status on plasma lipids, low density lipoprotein particle size, and apolipoproteins. 
  • Effect of sofosbuvir and ribavirin treatment on peripheral and hepatic lipid metabolism in chronic hepatitis C virus, genotype 1-infected patients. 
  • Effects of ammonium ion derived from bovine endothelial cells upon low density lipoprotein degradation in cultured vascular smooth muscle cells. 
  • Effects of combined supplementation with antioxidants on low-density lipoprotein oxidation. 
  • Effects of oxidized LDL on mononuclear phagocytes: inhibition of induction of four inflammatory cytokine gene RNAs, release of NO, and cytolysis of tumor cells. 
  • Electric field-induced redistribution and postfield relaxation of low density lipoprotein receptors on cultured human fibroblasts. 
  • Experimental determination of wall shear rate in canine carotid arteries perfused in vitro. 
  • Expression of type I and type II bovine scavenger receptors in Chinese hamster ovary cells: lipid droplet accumulation and nonreciprocal cross competition by acetylated and oxidized low density lipoprotein. 
  • Factors influencing the lipid response to selective alpha 1-inhibition. 
  • Fatty Acid binding protein 4 is associated with carotid atherosclerosis and outcome in patients with acute ischemic stroke. 
  • Fluorescent low density lipoprotein for observation of dynamics of individual receptor complexes on cultured human fibroblasts. 
  • Frequency and determinants of lipid testing in ischemic stroke and transient ischemic attack: findings from get with the guidelines-stroke. 
  • Gender and racial differences in lipoprotein subclass distributions: the STRRIDE study. 
  • Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations. 
  • Genetic Determinants of Circulating Lipoproteins in Nonalcoholic Fatty Liver Disease. 
  • Glycosylation of serum HDL and LDL in rats given excess retinol. 
  • HPLC measurement, blood distribution, and pharmacokinetics of oral clotrimazole, potentially useful antisickling agent. 
  • High normal plasma triglycerides are associated with preserved cognitive function in Chinese oldest-old. 
  • Hypercholesterolemia induces oxidant stress that accelerates the ageing of hematopoietic stem cells. 
  • Immunoreactivity of apolipoprotein B-100 in oxidatively modified low density lipoprotein. 
  • Inhibition of p38 Mitogen-Activated Protein Kinase Enhances the Apoptosis Induced by Oxidized Low-Density Lipoprotein in Endothelial Progenitor Cells. 
  • Interaction of low density lipoproteins with human aortic elastin. 
  • Is amyloid beta-protein glycated in Alzheimer's disease? 
  • Is nuclear magnetic resonance lipoprotein subclass related to diabetic retinopathy? The multi-ethnic study of atherosclerosis (MESA). 
  • Isolation and characterization of the two major apoproteins in human lipoprotein [a]. 
  • Kinetic analysis of the effects of glycosaminoglycans and lipoproteins on urokinase-mediated plasminogen activation. 
  • Kinetic analysis of the effects of heparin and lipoproteins on tissue plasminogen activator mediated plasminogen activation. 
  • Laboratory markers of cardiovascular risk in pediatric SLE: the APPLE baseline cohort. 
  • Lipid hydroperoxy and hydroxy derivatives in copper-catalyzed oxidation of low density lipoprotein. 
  • Lipoprotein particle concentration measured by nuclear magnetic resonance spectroscopy is associated with gestational age at delivery: a prospective cohort study. 
  • Low-density lipoprotein 4: a novel predictor of coronary artery disease severity. 
  • Low-density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor on murine peritoneal macrophages mediates the binding and catabolism of low-density lipoprotein. 
  • Maleylated-BSA induces hydrolysis of PIP2, fluxes of Ca2+, NF-kappaB binding, and transcription of the TNF-alpha gene in murine macrophages. 
  • Manganese-porphyrin reactions with lipids and lipoproteins. 
  • Measurement of endothelial permeability to 125I-low density lipoproteins in rabbit arteries by use of en face preparations. 
  • Metabolic cooperation between vascular endothelial cells and smooth muscle cells in co-culture: changes in low density lipoprotein metabolism. 
  • Microemulsions of phospholipids and cholesterol esters. Protein-free models of low density lipoprotein. 
  • Near-infrared optical imaging of B16 melanoma cells via low-density lipoprotein-mediated uptake and delivery of high emission dipole strength tris[(porphinato)zinc(II)] fluorophores. 
  • Neutral effect on markers of heart failure, inflammation, endothelial activation and function, and vagal tone after high-dose HMG-CoA reductase inhibition in non-diabetic patients with non-ischemic cardiomyopathy and average low-density lipoprotein level. 
  • Oxidized Low-Density Lipoprotein-β2-Glycoprotein I Complex But Not Free Oxidized LDL Is Associated With the Presence and Severity of Coronary Artery Disease. 
  • Oxidized low density lipoprotein suppresses activation of NF kappa B in macrophages via a pertussis toxin-sensitive signaling mechanism. 
  • Oxidized low-density lipoprotein induces apoptosis in endothelial progenitor cells by inactivating the phosphoinositide 3-kinase/Akt pathway. 
  • Oxidized low-density-lipoprotein-induced injury in retinal pigment epithelium alters expression of the membrane complement regulatory factors CD46 and CD59 through exosomal and apoptotic bleb release. 
  • Patient-provider internet portals--patient outcomes and use. 
  • Periodontal health improves systemic inflammatory and haemostatic status in subjects with coronary heart disease. 
  • Peroxynitrite flux-mediated LDL oxidation is inhibited by manganese porphyrins in the presence of uric acid. 
  • Pharmacometabolomics of statin response. 
  • Phospholipid hydrolytic enzymes in a 'cesspool' of arterial intimal lipoproteins: a mechanism for atherogenic lipid accumulation. 
  • Plasma lipoproteins of free-ranging howling monkeys (Alouatta palliata). 
  • Prediction of native coronary artery disease progression following PTCA or CABG in the Emory Angioplasty Versus Surgery Trial. 
  • Pro- and antiatherogenic effects of a dominant-negative P465L mutation of peroxisome proliferator-activated receptor-γ in apolipoprotein E-Null mice. 
  • Proprotein Convertase Subtilisin/Kexin Type 9 Monoclonal Antibodies for Acute Coronary Syndrome: A Narrative Review. 
  • Protection against oxidized low-density lipoprotein-induced vascular endothelial cell death by integrin-linked kinase. 
  • Reassembled plasma low density lipoproteins. Phospholipid-cholesterol ester-apoprotein B complexes. 
  • Receptors involved in the oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine-mediated synthesis of interleukin-8. A role for Toll-like receptor 4 and a glycosylphosphatidylinositol-anchored protein. 
  • Regression of atherosclerosis in monkeys reduces vascular superoxide levels. 
  • Regulation of lipoprotein metabolism by adrenergic mechanisms. 
  • Retinol feeding and low and high density lipoproteins of plasma of rats. 
  • Risk of stroke and cardiovascular events after ischemic stroke or transient ischemic attack in patients with type 2 diabetes or metabolic syndrome: secondary analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial. 
  • Role of homocysteine & MTHFR C677T gene polymorphism as risk factors for coronary artery disease in young Indians. 
  • SREC-I, a type F scavenger receptor, is an endocytic receptor for calreticulin. 
  • Serum lipid profile and risk of prostate cancer recurrence: Results from the SEARCH database. 
  • Spouse health behavior outcomes from a randomized controlled trial of a spouse-assisted lifestyle change intervention to improve patient low-density lipoprotein cholesterol. 
  • Supplementing claims data with outpatient laboratory test results to improve confounding adjustment in effectiveness studies of lipid-lowering treatments. 
  • The Bcl6-SMRT/NCoR cistrome represses inflammation to attenuate atherosclerosis. 
  • The Metabolic Syndrome and Risk of Sudden Cardiac Death: The Atherosclerosis Risk in Communities Study. 
  • The distribution of intimal white blood cells in the normal rabbit aorta. 
  • The effects of exercise on the lipoprotein subclass profile: A meta-analysis of 10 interventions. 
  • The role of lipoproteins in atherogenesis. 
  • To condition or not condition? Analysing 'change' in longitudinal randomised controlled trials. 
  • Toxicity of oxidized low density lipoproteins for vascular smooth muscle cells and partial protection by antioxidants. 
  • Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained. 
  • Transforming growth factor beta modulates gonadotropin receptor expression in porcine and rat granulosa cells differently. 
  • Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. 
  • Usefulness of Icosapent Ethyl (Eicosapentaenoic Acid Ethyl Ester) in Women to Lower Triglyceride Levels (Results from the MARINE and ANCHOR Trials). 
• 

  Keywords of People

  • McDonnell, Donald Patrick, Chair, Department of Pharmacology & Cancer Biology, Duke Innovation & Entrepreneurship
  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma
  • Schanberg, Laura Eve, Professor of Pediatrics, Pediatrics, Rheumatology