Liposomes

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  Subject Areas on Research

  • A dose-finding study of liposomal daunorubicin with CVP (COP-X) in advanced NHL. 
  • A dual-ligand approach for enhancing targeting selectivity of therapeutic nanocarriers. 
  • A fine line between molecular umbrella transport and ionophoric activity. 
  • A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo. 
  • A liposomal nanoscale contrast agent for preclinical CT in mice. 
  • A method to convert MRI images of temperature change into images of absolute temperature in solid tumours. 
  • A new temperature-sensitive liposome for use with mild hyperthermia: characterization and testing in a human tumor xenograft model. 
  • A prenylated p47phox-p67phox-Rac1 chimera is a Quintessential NADPH oxidase activator: membrane association and functional capacity. 
  • A subtransition in a phospholipid with a net charge, dipalmitoylphosphatidylglycerol. 
  • A tracer dose of technetium-99m-labeled liposomes can estimate the effect of hyperthermia on intratumoral doxil extravasation. 
  • Abnormalities of erythrocyte membranes in myotonic muscular dystrophy manifested in lipid vesicles. 
  • Achieving high permeability and enhanced selectivity for Angstrom-scale separations using artificial water channel membranes. 
  • Activated protein C cleaves factor Va more efficiently on endothelium than on platelet surfaces. 
  • Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation. 
  • Active immunization with tumor cells transduced by a novel AAV plasmid-based gene delivery system. 
  • Active immunotherapy with transiently transfected cytokine-secreting tumor cells inhibits breast cancer metastases in tumor-bearing animals. 
  • Adeno-associated virus gene transfer into renal cells: potential for in vivo gene delivery. 
  • Adjuvanticity and protective immunity of Plasmodium yoelii nigeriensis blood-stage soluble antigens encapsulated in fusogenic liposome. 
  • Administration technique of liposomal bupivacaine for total ankle arthroplasty. 
  • Amiodarone-liposome interaction: a multinuclear NMR and X-ray diffraction study. 
  • Amphotericin B lipid complex in the treatment of experimental cryptococcal meningitis and disseminated candidosis. 
  • Anti-invasive adjuvant therapy with imipramine blue enhances chemotherapeutic efficacy against glioma. 
  • Antisense oligodeoxynucleotide inhibition of vascular angiotensin-converting enzyme expression attenuates neointimal formation: evidence for tissue angiotensin-converting enzyme function. 
  • Antisense oligonucleotides directed at cell cycle regulatory genes as strategy for restenosis therapy. 
  • Apolipoprotein C-III/sphingomyelin recombinants: formation, isolation, and characterization. 
  • Assembly of translocation-competent proteoliposomes from detergent-solubilized rough microsomes. 
  • Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor. 
  • Bilayer interfacial properties modulate the binding of amphipathic peptides. 
  • Broad spectral domain fluorescence wavelength modulation of visible and near-infrared emissive polymersomes. 
  • CAMP-mediated inhibition of the renal brush border membrane Na+-H+ exchanger requires a dissociable phosphoprotein cofactor. 
  • Can regular solution theory be applied to lipid bilayer membranes? 
  • Cardiovascular phenotyping of the mouse heart using a 4D radial acquisition and liposomal Gd-DTPA-BMA. 
  • Cellular uptake and processing of surfactant lipids and apoprotein SP-A by rat lung. 
  • Cerivastatin Nanoliposome as a Potential Disease Modifying Approach for the Treatment of Pulmonary Arterial Hypertension. 
  • Chapter 1 - Tubular liposomes with variable permeability for reconstitution of FtsZ rings. 
  • Characterization of liposomes containing iodine-125-labeled radiographic contrast agents. 
  • Characterization of restricted diffusion in uni- and multi-lamellar vesicles using short distance iMQCs. 
  • Characterization of the effect of hyperthermia on nanoparticle extravasation from tumor vasculature. 
  • Chemodosimetry of in vivo tumor liposomal drug concentration using MRI. 
  • Chest discomfort associated with liposomal amphotericin B: report of three cases and review of the literature. 
  • Class I restricted CTL recognition of a soluble protein delivered by liposomes containing lipophilic polylysines. 
  • Clinical benefits of pegylated proteins in oncology. 
  • Comparative effects of thermosensitive doxorubicin-containing liposomes and hyperthermia in human and murine tumours. 
  • Computed tomography imaging of primary lung cancer in mice using a liposomal-iodinated contrast agent. 
  • Contributions of Asn2198, Met2199, and Phe2200 in the factor VIII C2 domain to cofactor activity, phospholipid-binding, and von Willebrand factor-binding. 
  • Controlled targeting of liposomal doxorubicin via the folate receptor in vitro. 
  • Cooperativity and binding in the mechanism of cytosolic phospholipase A2. 
  • Curved FtsZ protofilaments generate bending forces on liposome membranes. 
  • Cytosolic delivery of macromolecules 4. Head group-dependent membrane permeabilization by pH-sensitive detergents. 
  • Cytosolic delivery of macromolecules. 3. Synthesis and characterization of acid-sensitive bis-detergents. 
  • Cytosolic delivery of macromolecules. II. Mechanistic studies with pH-sensitive morpholine lipids. 
  • Cytosolic delivery of macromolecules: I. Synthesis and characterization of pH-sensitive acyloxyalkylimidazoles. 
  • DNA transfer into vascular smooth muscle using fusigenic Sendai virus (HVJ)-liposomes. 
  • Data analysis: evaluation of nanoscale contrast agent enhanced CT scan to differentiate between benign and malignant lung cancer in mouse model. 
  • Detection of infusate leakage in the brain using real-time imaging of convection-enhanced delivery. 
  • Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants. 
  • Direct demonstration of impaired functionality of a purified desensitized beta-adrenergic receptor in a reconstituted system. 
  • Direct electrochemistry of hemoglobin in egg-phosphatidylcholine films and its catalysis to H(2)O(2). 
  • Disc formation in cholesterol-free liposomes during phase transition. 
  • Divorcing folding from function: how acylation affects the membrane-perturbing properties of an antimicrobial peptide. 
  • Dual-Energy CT Imaging of Tumor Liposome Delivery After Gold Nanoparticle-Augmented Radiation Therapy. 
  • Dual-energy computed tomography imaging of atherosclerotic plaques in a mouse model using a liposomal-iodine nanoparticle contrast agent. 
  • Dual-energy micro-CT functional imaging of primary lung cancer in mice using gold and iodine nanoparticle contrast agents: a validation study. 
  • Dual-energy micro-computed tomography imaging of radiation-induced vascular changes in primary mouse sarcomas. 
  • Effect of chain length and unsaturation on elasticity of lipid bilayers. 
  • Effect of cytofectins on the immune response of murine macrophages to mammalian DNA. 
  • Effect of pazopanib on tumor microenvironment and liposome delivery. 
  • Effectiveness of combined interleukin 2 and B7.1 vaccination strategy is dependent on the sequence and order: a liposome-mediated gene therapy treatment for bladder cancer. 
  • Effects of antifungal agents and gamma interferon on macrophage cytotoxicity for fungi and tumor cells. 
  • Effects of topical application of free and liposome-encapsulated lactoferrin and lactoperoxidase on oral microbiota and dental caries in rats. 
  • Efficacy of liposomes and hyperthermia in a human tumor xenograft model: importance of triggered drug release. 
  • Efficient gene transfer with adeno-associated virus-based plasmids complexed to cationic liposomes for gene therapy of human prostate cancer. 
  • Efficient in vivo gene transfer into the heart in the rat myocardial infarction model using the HVJ (Hemagglutinating Virus of Japan)--liposome method. 
  • Electrostatic control of phospholipid polymorphism. 
  • Encapsulation and retention of chelated-copper inside hydrophobic nanoparticles: Liquid cored nanoparticles show better retention than a solid core formulation. 
  • Engineering Delivery Vehicles for Genome Editing. 
  • Evans blue nanocarriers visually demarcate margins of invasive gliomas. 
  • Evidence for direct local effect of angiotensin in vascular hypertrophy. In vivo gene transfer of angiotensin converting enzyme. 
  • Exchange of monooleoylphosphatidylcholine as monomer and micelle with membranes containing poly(ethylene glycol)-lipid. 
  • Fascia iliaca blockade with the addition of liposomal bupivacaine vs. plain bupivacaine for perioperative pain management following hip arthroscopy. 
  • Feasibility of laser targeted photo-occlusion of ocular vessels. 
  • Feasibility of laser-targeted photoocclusion of the choriocapillary layer in rats. 
  • Fetal gene transfer by transuterine injection of cationic liposome-DNA complexes. 
  • Fluorescence studies of benzo-[a]-pyrene in liposome membrane systems. 
  • Folate targeting of drug carriers: a mathematical model. 
  • Formulation and characterisation of magnetic resonance imageable thermally sensitive liposomes for use with magnetic resonance-guided high intensity focused ultrasound. 
  • Forty-eight hours of postoperative pain relief after total hip arthroplasty with a novel, extended-release epidural morphine formulation. 
  • Four-dimensional MR microscopy of the mouse heart using radial acquisition and liposomal gadolinium contrast agent. 
  • FtsZ Constriction Force - Curved Protofilaments Bending Membranes. 
  • Functional reconstitution of purified human Hv1 H+ channels. 
  • Fungal phospholipase activity and susceptibility to lipid preparations of amphotericin B. 
  • Fusigenic liposome-mediated DNA transfer into cardiac myocytes. 
  • Fusigenic viral liposome for gene therapy in cardiovascular diseases. 
  • Gelation of liposome interior. A novel method for drug encapsulation. 
  • Gene delivery systems in surgery. 
  • Gene silencing using RNA interference in embryonic stem cells. 
  • Gene therapy with an E2F transcription factor decoy inhibits cell cycle progression in rat anti-Thy 1 glomerulonephritis. 
  • Getting there is half the battle: recent advances in delivering therapeutics. 
  • HIV-1 antibodies and vaccine antigen selectively interact with lipid domains. 
  • High expression of nucleoside transporter protein hENT1 in Reed-Sternberg cells is associated with treatment failure in relapsed/refractory Hodgkin lymphoma patients treated with gemcitabine, vinorelbine and liposomal doxorubicin - a CALGB 59804 correlative study. 
  • High-resolution magnetic resonance angiography in the mouse using a nanoparticle blood-pool contrast agent. 
  • Holding back the sea: the role for maintenance chemotherapy in metastatic breast cancer. 
  • Hydrogen peroxide biosensor based on microperoxidase-11 entrapped in lipid membrane. 
  • Hyperthermia and liposomes. 
  • Hyperthermia enables tumor-specific nanoparticle delivery: effect of particle size. 
  • Hyperthermia increases accumulation of technetium-99m-labeled liposomes in feline sarcomas. 
  • Hyperthermia mediated liposomal drug delivery. 
  • Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression. 
  • ICAM-1 expression in autoimmune encephalitis visualized using magnetic resonance imaging. 
  • Imaging of convection enhanced delivery of toxins in humans. 
  • Impact of liposomal bupivacaine administration on postoperative pain in patients undergoing total knee replacement. 
  • Improved efficacy of stem cell labeling for magnetic resonance imaging studies by the use of cationic liposomes. 
  • Improvement in the antifilarial efficacy of doxycycline and rifampicin by combination therapy and drug delivery approach. 
  • In vivo cytotoxic T lymphocyte induction with soluble proteins administered in liposomes. 
  • In vivo monitoring of tissue pharmacokinetics of liposome/drug using MRI: illustration of targeted delivery. 
  • Increased microvascular permeability contributes to preferential accumulation of Stealth liposomes in tumor tissue. 
  • Induction of antibodies in rhesus macaques that recognize a fusion-intermediate conformation of HIV-1 gp41. 
  • Influence of lipid composition on physical properties and peg-mediated fusion of curved and uncurved model membrane vesicles: "nature's own" fusogenic lipid bilayer. 
  • Inside-out Z rings--constriction with and without GTP hydrolysis. 
  • Interaction of benzene with bilayers. Thermal and structural studies. 
  • Interactions between poly(2-ethylacrylic acid) and lipid bilayer membranes: effects of cholesterol and grafted poly(ethylene glycol). 
  • Intravesical liposome administration--a novel treatment for hyperactive bladder in the rat. 
  • Intravitreal liposome-encapsulated drugs: a preliminary human report. 
  • Ionic influences on the phase transition of dipalmitoylphosphatidylserine. 
  • Ionophore 4-BrA23187 transports Zn2+ and Mn2+ with high selectivity over Ca2+. 
  • Kupffer cell depletion by CI2MDP-liposomes alters hepatic cytokine expression and delays liver regeneration after partial hepatectomy. 
  • Lectin and epidermal growth factor domains of P-selectin at physiologic density are the recognition unit for leukocyte binding. 
  • Leishmania donovani infection enhances lateral mobility of macrophage membrane protein which is reversed by liposomal cholesterol. 
  • Lipid formulations of amphotericin B preserve and stabilize renal function in HSCT recipients. 
  • Lipid monolayer states and their relationships to bilayers. 
  • Lipopolysaccharides in bacterial membranes act like cholesterol in eukaryotic plasma membranes in providing protection against melittin-induced bilayer lysis. 
  • Liposomal Bupivacaine Versus Continuous Popliteal Sciatic Nerve Block in Total Ankle Arthroplasty. 
  • Liposomal amphotericin B: clinical experience and perspectives. 
  • Liposomal bupivacaine in forefoot surgery. 
  • Liposomal delivery of soluble protein antigens for class I MHC-mediated antigen presentation. 
  • Liposome reconstitution and transport assay for recombinant transporters. 
  • Liposome-mediated DNA uptake and transient expression in Thermotoga. 
  • Liposome-mediated augmentation of superoxide dismutase in endothelial cells prevents oxygen injury. 
  • Liposome-mediated conformation transition of DNA detected by molecular probe: methyl green. 
  • Liposomes as antigen delivery systems in viral immunity. 
  • Liposomes-entrapped chondroitin sulphate: ultrastructural characterization and in vitro biocompatibility. 
  • Long- and short-range interactions between phospholipid/ganglioside GM1 bilayers. 
  • Long-circulating liposomal contrast agents for magnetic resonance imaging. 
  • Long-residence-time nano-scale liposomal iohexol for X-ray-based blood pool imaging. 
  • Lysolipid incorporation in dipalmitoylphosphatidylcholine bilayer membranes enhances the ion permeability and drug release rates at the membrane phase transition. 
  • Macrophage depletion diminishes lesion size and severity in experimental choroidal neovascularization. 
  • Magnetic resonance imaging of temperature-sensitive liposome release: drug dose painting and antitumor effects. 
  • Management of invasive mycoses in hematology patients: current approaches. 
  • Masking and triggered unmasking of targeting ligands on nanocarriers to improve drug delivery to brain tumors. 
  • Materials characterization of the low temperature sensitive liposome (LTSL): effects of the lipid composition (lysolipid and DSPE-PEG2000) on the thermal transition and release of doxorubicin. 
  • Measurement of material extravasation in microvascular networks using fluorescence video-microscopy. 
  • Mechanism and specificity of lanthanide series cation transport by ionophores A23187, 4-BrA23187, and ionomycin. 
  • Mechanism of guanine nucleotide regulatory protein-mediated inhibition of adenylate cyclase. Studies with isolated subunits of transducin in a reconstituted system. 
  • Mechanisms of beta-adrenergic receptor desensitization and resensitization. 
  • Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent. 
  • Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft. 
  • Mitochondrial localization of Reaper to promote inhibitors of apoptosis protein degradation conferred by GH3 domain-lipid interactions. 
  • Morphology of proteoliposomes reconstituted with purified lac carrier protein from Escherichia coli. 
  • Morphology of the intermediate stages in the lamellar to hexagonal lipid phase transition. 
  • Mortality rates in comparative trials of formulations of amphotericin B. 
  • Nanocarrier-mediated inhibition of macrophage migration inhibitory factor attenuates secondary injury after spinal cord injury. 
  • Near-infrared-emissive polymersomes: self-assembled soft matter for in vivo optical imaging. 
  • Negative-stain electron microscopy of inside-out FtsZ rings reconstituted on artificial membrane tubules show ribbons of protofilaments. 
  • Neuronal SNAREs do not trigger fusion between synthetic membranes but do promote PEG-mediated membrane fusion. 
  • Non-invasive monitoring of intra-tumor drug concentration and therapeutic response using optical spectroscopy. 
  • Nonendocytic delivery of lipoplex nanoparticles into living cells using nanochannel electroporation. 
  • Noninvasive imaging of cationic lipid-mediated delivery of optical and PET reporter genes in living mice. 
  • Noninvasive visualization of blood flow in the choriocapillaris of the rat. 
  • Noninvasive visualization of the choriocapillaris and its dynamic filling. 
  • Novel and effective gene transfer technique for study of vascular renin angiotensin system. 
  • Novel approaches to treatment of hepatocellular carcinoma and hepatic metastases using thermal ablation and thermosensitive liposomes. 
  • Novel in vitro gene transfer method for study of local modulators in vascular smooth muscle cells. 
  • O-Alkyl dioleoylphosphatidylcholinium compounds: the effect of varying alkyl chain length on their physical properties and in vitro DNA transfection activity. 
  • Optically modulated cancer therapeutic delivery: past, present and future. 
  • Overcoming limitations in nanoparticle drug delivery: triggered, intravascular release to improve drug penetration into tumors. 
  • Paramagnetic polymerized liposomes as new recirculating MR contrast agents. 
  • Pharmacokinetics of antisense oligodeoxyribonucleotides (cyclin B1 and CDC 2 kinase) in the vessel wall in vivo: enhanced therapeutic utility for restenosis by HVJ-liposome delivery. 
  • Pharmacokinetics of doxorubicin administered i.v. as Myocet (TLC D-99; liposome-encapsulated doxorubicin citrate) compared with conventional doxorubicin when given in combination with cyclophosphamide in patients with metastatic breast cancer. 
  • Phase I trial of doxorubicin-containing low temperature sensitive liposomes in spontaneous canine tumors. 
  • Phase-lifetime spectrophotometry of deoxycholate-purified bacteriorhodopsin reconstituted into asolectin vesicles. 
  • Plasmodium falciparum malaria: band 3 as a possible receptor during invasion of human erythrocytes. 
  • Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid. 
  • Preclinical Evaluation of Promitil, a Radiation-Responsive Liposomal Formulation of Mitomycin C Prodrug, in Chemoradiotherapy. 
  • Preferential extravasation and accumulation of liposomal vincristine in tumor comparing to normal tissue enhances antitumor activity. 
  • Preparation and characterization of unilamellar vesicles from cholate-phospholipid micelle treated with cholestyramine. 
  • Preparation and preclinical evaluation of a novel liposomal complete-core lipopolysaccharide vaccine. 
  • Preparation of in vivo cleavable agglomerated liposomes suitable for modulated pulmonary drug delivery. 
  • Preparation of thin, fine-grained, tantalum metal replicas for freeze-fracture electron microscopy. 
  • Presence of glycerol masks the effects of phosphorylation on the catalytic efficiency of cytosolic phospholipase A2. 
  • Prevention of acute lung injury in swine: depletion of pulmonary intravascular macrophages using liposomal clodronate. 
  • Prevention of restenosis by gene therapy. 
  • Priming for virus-specific CD8+ but not CD4+ cytotoxic T lymphocytes with synthetic lipopeptide is influenced by acylation units and liposome encapsulation. 
  • Properties of multilamellar liposomes containing 99mTcO4-: effect of distearoylphosphatidylcholine to sphingomyelin ratio. 
  • Prospective assessment of quality of life in ovarian cancer patients receiving whole abdomen hyperthermia and liposomal doxorubicin. 
  • Protective effect of nifedipine against carrageenan-induced inflammation. 
  • Purification and reconstitution of the calcium release channel from skeletal muscle. 
  • Range and magnitude of the steric pressure between bilayers containing phospholipids with covalently attached poly(ethylene glycol). 
  • Rational identification of a novel peptide for targeting nanocarriers to 9L glioma. 
  • Rationale for and measurement of liposomal drug delivery with hyperthermia using non-invasive imaging techniques. 
  • Reconstitution of a hormone-sensitive adenylate cyclase system. The pure beta-adrenergic receptor and guanine nucleotide regulatory protein confer hormone responsiveness on the resolved catalytic unit. 
  • Reconstitution of beta-adrenergic receptors in lipid vesicles: affinity chromatography-purified receptors confer catecholamine responsiveness on a heterologous adenylate cyclase system. 
  • Reconstitution of contractile FtsZ rings in liposomes. 
  • Recycling of surfactant lipid and apoprotein-A studied by electron microscopic autoradiography. 
  • Reducing liposome size with ultrasound: bimodal size distributions. 
  • Regulation of renal Na(+)-H+ exchanger by cAMP-dependent protein kinase. 
  • Regulation of the renal Na(+)-H+ exchanger by calcium calmodulin-dependent multifunctional protein kinase II. 
  • Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. 
  • Remote triggered release of doxorubicin in tumors by synergistic application of thermosensitive liposomes and gold nanorods. 
  • Resistance of pancreatic carcinoma cells is reversed by coculturing NK-like T cells with dendritic cells pulsed with tumor-derived RNA and CA 19-9. 
  • Role of macrophages and dendritic cells in primary cytotoxic T lymphocyte responses. 
  • Selective targeting of nanocarriers to neutrophils and monocytes. 
  • Selective visualization of choroidal neovascular membranes. 
  • Simultaneous measurement of liposome extravasation and content release in tumors. 
  • Single intraluminal delivery of antisense cdc2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia. 
  • Size matters--nanotechnology and therapeutics in rheumatology and immunology. 
  • Size-controlled lipid nanoparticle production using turbulent mixing to enhance oral DNA delivery. 
  • Solubility of carbon dioxide in lipid bilayer membranes and organic solvents. 
  • Solubilization and reconstitution of renal brush border Na+-H+ exchanger. 
  • Soluble proteins delivered to dendritic cells via pH-sensitive liposomes induce primary cytotoxic T lymphocyte responses in vitro. 
  • Spatial relationships between specific sites on reconstituted chloroplast proton adenosinetriphosphatase and the phospholipid vesicle surface. 
  • Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles. 
  • Stable docking of neutralizing human immunodeficiency virus type 1 gp41 membrane-proximal external region monoclonal antibodies 2F5 and 4E10 is dependent on the membrane immersion depth of their epitope regions. 
  • Steady state kinetics of ATP synthesis and hydrolysis catalyzed by reconstituted chloroplast coupling factor. 
  • Structural changes in the photoactive site of proteorhodopsin during the primary photoreaction. 
  • Structure and phase behavior of lipid suspensions containing phospholipids with covalently attached poly(ethylene glycol). 
  • Suppression of pancreatic tumor progression by systemic delivery of a pancreatic-cancer-specific promoter driven Bik mutant. 
  • Systemic administration of HVJ viral coat-liposome complex containing human insulin vector decreases glucose level in diabetic mouse: A model of gene therapy. 
  • Systemic toxicology and laser safety of laser targeted angiography with heat sensitive liposomes. 
  • Targeted drug delivery to C6 glioma by transferrin-coupled liposomes. 
  • Targeted gene therapy for rat glomerulonephritis using HVJ-immunoliposomes. 
  • Targeting tumor microvessels using doxorubicin encapsulated in a novel thermosensitive liposome. 
  • Technology evaluation: gene therapy (IL-2), Valentis Inc. 
  • Tension-stabilized pores in giant vesicles: determination of pore size and pore line tension. 
  • The D2-dopamine receptor of anterior pituitary is functionally associated with a pertussis toxin-sensitive guanine nucleotide binding protein. 
  • The Holy Grail: long-acting local anaesthetics and liposomes. 
  • The anion exchanger and Na+K(+)-ATPase interact with distinct sites on ankyrin in in vitro assays. 
  • The biological activity of a liposomal complete core lipopolysaccharide vaccine. 
  • The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors. 
  • The influence of lipofectin on the in vitro stimulation of murine spleen cells by bacterial DNA and plasmid DNA vectors. 
  • The major allergen from birch tree pollen, Bet v 1, binds and permeabilizes membranes. 
  • The mammalian beta 2-adrenergic receptor: reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system. 
  • The materials engineering of temperature-sensitive liposomes. 
  • The noneffect of a large linear hydrocarbon, squalene, on the phosphatidylcholine packing structure. 
  • The organization of n-alkanes in lipid bilayers. 
  • The role of antibody polyspecificity and lipid reactivity in binding of broadly neutralizing anti-HIV-1 envelope human monoclonal antibodies 2F5 and 4E10 to glycoprotein 41 membrane proximal envelope epitopes. 
  • The role of carrier size in the pharmacodynamics of antisense and siRNA oligonucleotides. 
  • The role of cavitation in liposome formation. 
  • The size and curvature of anionic covesicle substrate affects the catalytic action of cytosolic phospholipase A2. 
  • The voltage-dependent anion channel is a receptor for plasminogen kringle 5 on human endothelial cells. 
  • The water permeability of lens aquaporin-0 depends on its lipid bilayer environment. 
  • Thermo-responsive systems for controlled drug delivery. 
  • Thermosensitive liposomes: extravasation and release of contents in tumor microvascular networks. 
  • Topology of the yeast plasma membrane proton-translocating ATPase. 
  • Transcription factor decoy to study the molecular mechanism of negative regulation of renin gene expression in the liver in vivo. 
  • Transducin and the inhibitory nucleotide regulatory protein inhibit the stimulatory nucleotide regulatory protein mediated stimulation of adenylate cyclase in phospholipid vesicle systems. 
  • Transmission of a procoagulant signal from tissue factor-bearing cell to platelets. 
  • Treatment with imatinib improves drug delivery and efficacy in NSCLC xenografts. 
  • Tumor microvascular permeability is a key determinant for antivascular effects of doxorubicin encapsulated in a temperature sensitive liposome. 
  • Two types of mechanosensitive channels in the Escherichia coli cell envelope: solubilization and functional reconstitution. 
  • Ultrasound-mediated release of hydrophilic and lipophilic agents from echogenic liposomes. 
  • Urodynamic and immunohistochemical evaluation of intravesical capsaicin delivery using thermosensitive hydrogel and liposomes. 
  • Use of liposomes as carriers for radiation synovectomy. 
  • Use of newer antifungal therapies in clinical practice: what do the data tell us? 
  • Vaccination with mRNAs encoding tumor-associated antigens and granulocyte-macrophage colony-stimulating factor efficiently primes CTL responses, but is insufficient to overcome tolerance to a model tumor/self antigen. 
  • Vaccine-induced HIV-1 envelope gp120 constant region 1-specific antibodies expose a CD4-inducible epitope and block the interaction of HIV-1 gp140 with galactosylceramide. 
  • Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. 
  • Vitamin A in liposomes. Inhibition of complement binding and alteration of membrane structure. 
  • WRP/srGAP3 facilitates the initiation of spine development by an inverse F-BAR domain, and its loss impairs long-term memory. 
  • Water permeability of aquaporin-4 channel depends on bilayer composition, thickness, and elasticity. 
  • pH dependence of adenosine 5'-triphosphate synthesis and hydrolysis catalyzed by reconstituted chloroplast coupling factor. 
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  Keywords of People

  • Badea, Cristian Tudorel, Professor in Radiology, Radiology
  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Charles, Hal Cecil, Associate Professor of Radiology, Radiology
  • Craciunescu, Oana, Associate Professor of Radiation Oncology, Radiation Oncology
  • Erickson, Harold Paul, James B. Duke Professor of Cell Biology, Biomedical Engineering
  • Ferrari, Guido, Associate Professor of Surgery, Molecular Genetics and Microbiology
  • Johnson, G. Allan, Charles E. Putman University Professor of Radiology, Physics
  • Palmer, Gregory M., Associate Professor of Radiation Oncology, Radiation Oncology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Immunology
  • Soderling, Scott Haydn, Professor in Cell Biology, Cell Biology