Lod Score

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  Subject Areas on Research

  • A combined genomewide linkage scan of 1,233 families for prostate cancer-susceptibility genes conducted by the international consortium for prostate cancer genetics. 
  • A duplication in chromosome 4q35 is associated with hereditary benign intraepithelial dyskeratosis. 
  • A genetic linkage map of Cryptococcus neoformans variety neoformans serotype D (Filobasidiella neoformans). 
  • A genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins. 
  • A genome-wide linkage analysis of dementia in the Amish. 
  • A genome-wide search for linkage to asthma phenotypes in the genetics of asthma international network families: evidence for a major susceptibility locus on chromosome 2p. 
  • A genomewide scan for early-onset coronary artery disease in 438 families: the GENECARD Study. 
  • A genomewide screen in multiplex rheumatoid arthritis families suggests genetic overlap with other autoimmune diseases. 
  • A human model for multigenic inheritance: phenotypic expression in Hirschsprung disease requires both the RET gene and a new 9q31 locus. 
  • A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter. 
  • A locus for cerebral cavernous malformations maps to chromosome 7q in two families. 
  • A locus for generalized tonic-clonic seizure susceptibility maps to chromosome 10q25-q26. 
  • A new locus for familial FSGS on chromosome 2p. 
  • A physical map across chromosome 11q22-q23 containing the major locus for ataxia telangiectasia. 
  • A second locus for hereditary hemorrhagic telangiectasia maps to chromosome 12. 
  • A second-generation genomic screen for multiple sclerosis. 
  • A variable age of onset segregation model for linkage analysis, with correction for ascertainment, applied to glioma. 
  • Affected-sib-pair interval mapping and exclusion for complex genetic traits: sampling considerations. 
  • Age at onset in two common neurodegenerative diseases is genetically controlled. 
  • Age-related maculopathy: a genomewide scan with continued evidence of susceptibility loci within the 1q31, 10q26, and 17q25 regions. 
  • An autosomal genomic screen for dementia in an extended Amish family. 
  • An international collaborative family-based whole genome quantitative trait linkage scan for myopic refractive error. 
  • An international collaborative family-based whole-genome linkage scan for high-grade myopia. 
  • An investigation of genetic heterogeneity and linkage disequilibrium in 161 families with spinal muscular atrophy. 
  • Analysis of Huntington disease linkage and age-of-onset distributions. 
  • Analysis of the prostate cancer-susceptibility locus HPC20 in 172 families affected by prostate cancer. 
  • Apolipoprotein E genotype and major depression in a community of older adults. The Cache County Study. 
  • Autosomal dominant macrothrombocytopenia with leukocyte inclusions (May-Hegglin anomaly) is linked to chromosome 22q12-13. 
  • Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene. 
  • BRCA1 maps proximal to D17S579 on chromosome 17q21 by genetic analysis. 
  • CC-chemokine receptor 5 polymorphism and age of onset in familial multiple sclerosis. Multiple Sclerosis Genetics Group. 
  • Chorea-acanthocytosis: genetic linkage to chromosome 9q21. 
  • Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG. 
  • Clinical and genetic heterogeneity in familial focal segmental glomerulosclerosis. International Collaborative Group for the Study of Familial Focal Segmental Glomerulosclerosis. 
  • Combined genome-wide scan for prostate cancer susceptibility genes. 
  • Common familial colorectal cancer linked to chromosome 7q31: a genome-wide analysis. 
  • Compelling evidence for a prostate cancer gene at 22q12.3 by the International Consortium for Prostate Cancer Genetics. 
  • Complete genomic screen for disease susceptibility loci in nuclear families. 
  • Complete genomic screen in Parkinson disease: evidence for multiple genes. 
  • Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12. 
  • Confirmation of a second locus for CMT2 and evidence for additional genetic heterogeneity. 
  • Confirmation of linkage in von Hippel-Lindau disease. 
  • Confirmation of linkage of oculopharyngeal muscular dystrophy to chromosome 14q11.2-q13. 
  • Covariate analysis of late-onset Alzheimer disease refines the chromosome 12 locus. 
  • Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9. 
  • Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis. 
  • Early adult-onset POAG linked to 15q11-13 using ordered subset analysis. 
  • Effects of covariates: a summary of Group 5 contributions. 
  • Evidence for genetic homogeneity in a familial platelet disorder with predisposition to acute myelogenous leukemia (FPD/AML). 
  • Evidence that a locus for familial high myopia maps to chromosome 18p. 
  • Examination of seven candidate regions for multiple sclerosis: strong evidence of linkage to chromosome 1q44. 
  • Exclusion of TIMP3 as a candidate locus in age-related macular degeneration. 
  • Exclusion of identified LGMD1 loci from four dominant limb-girdle muscular dystrophy families. 
  • Exclusion of lumican and fibromodulin as candidate genes in MYP3 linked high grade myopia. 
  • Familial chordoma, a tumor of notochordal remnants, is linked to chromosome 7q33. 
  • Fine mapping and genetic heterogeneity in the pure form of autosomal dominant familial spastic paraplegia. 
  • Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p. 
  • Fine mapping of autistic disorder to chromosome 15q11-q13 by use of phenotypic subtypes. 
  • Fine mapping of the chromosome 12 late-onset Alzheimer disease locus: potential genetic and phenotypic heterogeneity. 
  • Fine structure mapping of CIAS1: identification of an ancestral haplotype and a common FCAS mutation, L353P. 
  • Fine-mapping the putative chromosome 17q21-22 prostate cancer susceptibility gene to a 10 cM region based on linkage analysis. 
  • Further exclusion of FSHD1B from the telomeric region of 10q. 
  • GATA2 is associated with familial early-onset coronary artery disease. 
  • Genetic Architecture of a Morphological Shape Difference Between Two Drosophila Species 
  • Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci. 
  • Genetic analysis of eight breast-ovarian cancer families with suspected BRCA1 mutations. 
  • Genetic and functional association of FAM5C with myocardial infarction. 
  • Genetic basis for clinical expression in multiple sclerosis. 
  • Genetic complexity and Parkinson's disease. Deane Laboratory Parkinson Disease Research Group. 
  • Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14. 
  • Genetic linkage mapping of chromosome 17 markers and neurofibromatosis type I. 
  • Genetic linkage of hyper-IgE syndrome to chromosome 4. 
  • Genetic linkage studies of chromosome 17 RFLPs in von Recklinghausen neurofibromatosis (NF1). 
  • Genetic linkage study of high-grade myopia in a Hutterite population from South Dakota. 
  • Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. 
  • Genetic mapping of a novel familial form of infantile hemangioma. 
  • Genetic studies in autistic disorder and chromosome 15. 
  • Genetic studies of autistic disorder and chromosome 7. 
  • Genome-wide high-density SNP linkage search for glioma susceptibility loci: results from the Gliogene Consortium. 
  • Genome-wide linkage analysis of cardiovascular disease biomarkers in a large, multigenerational family. 
  • Genome-wide linkage analysis of quantitative biomarker traits of osteoarthritis in a large, multigenerational extended family. 
  • Genome-wide linkage of 77 families from the African American Hereditary Prostate Cancer study (AAHPC). 
  • Genome-wide linkage scan for prostate cancer susceptibility from the University of Michigan Prostate Cancer Genetics Project: suggestive evidence for linkage at 16q23. 
  • Genome-wide linkage scan for prostate cancer susceptibility genes in men with aggressive disease: significant evidence for linkage at chromosome 15q12. 
  • Genome-wide linkage scan in fuchs endothelial corneal dystrophy. 
  • Genome-wide linkage screen in familial Parkinson disease identifies loci on chromosomes 3 and 18. 
  • Genome-wide scan for adult onset primary open angle glaucoma. 
  • Genomewide search for type 2 diabetes susceptibility genes in four American populations. 
  • Genomic screen and follow-up analysis for autistic disorder. 
  • Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. 
  • Grade-of-membership sibpair linkage analysis maps IDDM11 to chromosome 14q24.3-q31. 
  • Haplotype analysis in Icelandic families defines a minimal interval for the macular corneal dystrophy type I gene. 
  • Identification and expression analysis of spastin gene mutations in hereditary spastic paraplegia. 
  • Identification of a new locus for autosomal recessive Charcot-Marie-Tooth disease with focally folded myelin on chromosome 11p15. 
  • Identification of genetic markers to 20 NIDDM candidate genes by radiation hybrid analysis. 
  • Identification of novel genes in late-onset Alzheimer's disease. 
  • Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease. 
  • Identification of susceptibility loci contributing to a complex disease using conventional segregation, linkage, and association methods. 
  • Identification of two novel loci for dominantly inherited familial amyotrophic lateral sclerosis. 
  • Investigation of Notch3 as a candidate gene for bipolar disorder using brain hyperintensities as an endophenotype. 
  • Juvenile bilateral lens dislocation and glaucoma associated with a novel mutation in the fibrillin 1 gene. 
  • Linkage analysis for age-related macular degeneration supports a gene on chromosome 10q26. 
  • Linkage analysis in von Recklinghausen neurofibromatosis (NF1) with DNA markers for chromosome 17. 
  • Linkage analysis with gene-environment interaction: model illustration and performance of ordered subset analysis. 
  • Linkage and association analysis of chromosome 19q13 in multiple sclerosis. 
  • Linkage disequilibrium inflates type I error rates in multipoint linkage analysis when parental genotypes are missing. 
  • Linkage of 'pure' autosomal recessive familial spastic paraplegia to chromosome 8 markers and evidence of genetic locus heterogeneity. 
  • Linkage of Charcot-Marie-Tooth neuropathy type 1a to chromosome 17. 
  • Linkage of a gene causing familial amyotrophic lateral sclerosis to chromosome 21 and evidence of genetic-locus heterogeneity. 
  • Linkage of a gene causing familial membranoproliferative glomerulonephritis type III to chromosome 1. 
  • Linkage of a locus for autosomal dominant familial spastic paraplegia to chromosome 2p markers. 
  • Linkage of familial amyotrophic lateral sclerosis with frontotemporal dementia to chromosome 9q21-q22. 
  • Linkage of familial dilated cardiomyopathy with conduction defect and muscular dystrophy to chromosome 6q23. 
  • Linkage of recessive familial amyotrophic lateral sclerosis to chromosome 2q33-q35. 
  • Linkage of scapuloperoneal spinal muscular atrophy to chromosome 12q24.1-q24.31. 
  • Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage. 
  • Localization of Charcot-Marie-Tooth disease type 1a (CMT1A) to chromosome 17p11.2. 
  • Localization of a gene (CMT2A) for autosomal dominant Charcot-Marie-Tooth disease type 2 to chromosome 1p and evidence of genetic heterogeneity. 
  • Locus heterogeneity, anticipation and reduction of the chromosome 2p minimal candidate region in autosomal dominant familial spastic paraplegia. 
  • Mapping autism risk loci using genetic linkage and chromosomal rearrangements. 
  • Microphthalmia-associated transcription factor (MITF) locus lacks linkage to human vitiligo or osteopetrosis: an evaluation. 
  • Molecular analysis of recombination in a family with Duchenne muscular dystrophy and a large pericentric X chromosome inversion. 
  • Multiple quantitative trait loci modify the heart failure phenotype in murine cardiomyopathy. 
  • Multiple susceptibility loci for multiple sclerosis. 
  • Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A. 
  • Natural allelic variation of the IL-21 receptor modulates ischemic stroke infarct volume. 
  • Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis. 
  • New locus for autosomal dominant high myopia maps to the long arm of chromosome 17. 
  • No association between alpha 1-antichymotrypsin and familial Alzheimer's disease. 
  • No association or linkage between an intronic polymorphism of presenilin-1 and sporadic or late-onset familial Alzheimer disease. 
  • No genetic association between the LRP receptor and sporadic or late-onset familial Alzheimer disease. 
  • North Carolina macular dystrophy (MCDR1) locus: a fine resolution genetic map and haplotype analysis. 
  • Ordered subset analysis in genetic linkage mapping of complex traits. 
  • Ordered subset linkage analysis supports a susceptibility locus for age-related macular degeneration on chromosome 16p12. 
  • Ordered-subset analysis of savant skills in autism for 15q11-q13. 
  • Ordered-subsets linkage analysis detects novel Alzheimer disease loci on chromosomes 2q34 and 15q22. 
  • Pedigree selection and information content. 
  • Phenotypic definition of Chiari type I malformation coupled with high-density SNP genome screen shows significant evidence for linkage to regions on chromosomes 9 and 15. 
  • Phenotypic homogeneity provides increased support for linkage on chromosome 2 in autistic disorder. 
  • Potential for expanded power in linkage studies using the ALLEGRO and MERLIN software programs. 
  • QTL mapping in a mouse model of cardiomyopathy reveals an ancestral modifier allele affecting heart function and survival. 
  • Reduction in the minimum candidate interval in the dominant-intermediate form of Charcot-Marie-Tooth neuropathy to D19S586 to D19S432. 
  • Refined localization of the cerebral cavernous malformation gene (CCM1) to a 4-cM interval of chromosome 7q contained in a well-defined YAC contig. 
  • Refinement of the X-linked nonsyndromic high-grade myopia locus MYP1 on Xq28 and exclusion of 13 known positional candidate genes by direct sequencing. 
  • Replication of the recessive STBMS1 locus but with dominant inheritance. 
  • SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease. 
  • Screening the genome for rheumatoid arthritis susceptibility genes: a replication study and combined analysis of 512 multicase families. 
  • Segregation and linkage analysis of alpha-N-acetyl-D-glucosaminidase (NAG) levels in a black family. 
  • Serum lipids in the GENECARD study of coronary artery disease identify quantitative trait loci and phenotypic subsets on chromosomes 3q and 5q. 
  • Stratified whole genome linkage analysis of Chiari type I malformation implicates known Klippel-Feil syndrome genes as putative disease candidates. 
  • Support of linkage of Gerstmann-Sträussler-Scheinker syndrome to the prion protein gene on chromosome 20p12-pter. 
  • The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. I. An autosomal genome scan for genes that predispose to type 2 diabetes. 
  • The genetic basis of developmental abnormalities in interpopulation hybrids of the moss Ceratodon purpureus. 
  • The human glycine receptor: a new probe that is linked to the X-linked hypophosphatemic rickets gene. 
  • Tight linkage of creatine kinase (CKMM) to myotonic dystrophy on chromosome 19. 
  • Two-locus genome-wide linkage scan for prostate cancer susceptibility genes with an interaction effect. 
  • Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma. 
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  Keywords of People

  • Liu, Yutao, Adjunct Assistant Professor in the Department of Medicine, Medicine, Medical Genetics