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Subject Areas on Research
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A 40-kilodalton protein binds specifically to an upstream sequence element essential for muscle-specific transcription of the human myoglobin promoter.
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A CRISPR Activation Screen Identifies a Pan-avian Influenza Virus Inhibitory Host Factor.
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A family of hierarchically self-assembling linear-dendritic hybrid polymers for highly efficient targeted gene delivery.
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A functional variant (-1304T>G) in the MKK4 promoter contributes to a decreased risk of lung cancer by increasing the promoter activity.
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A functional variant at the miR-184 binding site in TNFAIP2 and risk of squamous cell carcinoma of the head and neck.
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A molecular mechanism for the differential regulation of TGF-beta1 expression due to the common SNP -509C-T (c. -1347C > T).
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A normothermic ex vivo organ perfusion delivery method for cardiac transplantation gene therapy.
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A physical interaction network of dengue virus and human proteins.
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A pressure-mediated nonviral method for efficient arterial gene and oligonucleotide transfer.
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A small-molecule antagonist of the hedgehog signaling pathway.
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Activated cAMP-response element-binding protein regulates neuronal expression of presenilin-1.
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Activator protein-1 has an essential role in pancreatic cancer cells and is regulated by a novel Akt-mediated mechanism.
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Activity of a type 1 picornavirus internal ribosomal entry site is determined by sequences within the 3' nontranslated region.
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Adeno-associated viral vectors based on serotype 3b use components of the fibroblast growth factor receptor signaling complex for efficient transduction.
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Allelic diversity in the TGFB1 regulatory region: characterization of novel functional single nucleotide polymorphisms.
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Alpha V integrin prolongs collagenase production through Jun activation binding protein 1.
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An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa.
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An oligonucleotide decoy for transcription factor E2F inhibits mesangial cell proliferation in vitro.
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Androgen receptor down-regulation in prostate cancer with phosphorodiamidate morpholino antisense oligomers.
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Association of a functional tandem repeats in the downstream of human telomerase gene and lung cancer.
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Ataxia-telangiectasia group D complementing gene (ATDC) promotes lung cancer cell proliferation by activating NF-κB pathway.
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Atrial shunt device for heart failure with preserved and mildly reduced ejection fraction (REDUCE LAP-HF II): a randomised, multicentre, blinded, sham-controlled trial.
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Bioluminescent virion shells: new tools for quantitation of AAV vector dynamics in cells and live animals.
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COMMD proteins, a novel family of structural and functional homologs of MURR1.
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Caspase 3 promotes surviving melanoma tumor cell growth after cytotoxic therapy.
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Cellular arrays for large-scale analysis of transcription factor activity.
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Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters.
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Collaborative interactions between MEF-2 and Sp1 in muscle-specific gene regulation.
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Competing Pathways and Multiple Folding Nuclei in a Large Multidomain Protein, Luciferase.
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Competitive translation efficiency at the picornavirus type 1 internal ribosome entry site facilitated by viral cis and trans factors.
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Conditional gene silencing in mammalian cells mediated by a stress-inducible promoter.
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Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades.
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Cooperation between core binding factor and adjacent promoter elements contributes to the tissue-specific expression of interleukin-3.
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Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity.
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Cyclic AMP mediated GSTP1 gene activation in tumor cells involves the interaction of activated CREB-1 with the GSTP1 CRE: a novel mechanism of cellular GSTP1 gene regulation.
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Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment.
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Derivation and characterization of a simian immunodeficiency virus SIVmac239 variant with tropism for CXCR4.
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Design and characterization of microporous hyaluronic acid hydrogels for in vitro gene transfer to mMSCs
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Design, expression, and immunogenicity of a soluble HIV trimeric envelope fragment adopting a prefusion gp41 configuration.
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Determination of neutralization activities by a new versatile assay using an HIV-1 genome carrying the Gaussia luciferase gene.
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Development of a novel screen for protease inhibitors.
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Differential CD4/CCR5 utilization, gp120 conformation, and neutralization sensitivity between envelopes from a microglia-adapted human immunodeficiency virus type 1 and its parental isolate.
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Differential expression of intracellular and secreted osteopontin isoforms by murine macrophages in response to toll-like receptor agonists.
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Differential osteopontin expression in phenotypically distinct subclones of murine breast cancer cells mediates metastatic behavior.
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Dioxin induces transcription of fos and jun genes by Ah receptor-dependent and -independent pathways.
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Divergent pathways mediate the induction of ANF transgenes in neonatal and hypertrophic ventricular myocardium.
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Effect of allelic variation at the NACP-Rep1 repeat upstream of the alpha-synuclein gene (SNCA) on transcription in a cell culture luciferase reporter system.
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Effects of rate, volume, and dose of intratumoral infusion on virus dissemination in local gene delivery.
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Efficient in vivo gene transfer into the heart in the rat myocardial infarction model using the HVJ (Hemagglutinating Virus of Japan)--liposome method.
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Enhancement of rAAV2-mediated transgene expression in retina cells in vitro and in vivo by coadministration of low-dose chemotherapeutic drugs.
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Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice.
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Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6.
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Evaluating cell-surface expression and measuring activation of mammalian odorant receptors in heterologous cells.
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Evaluating neutralizing antibodies against HIV, SIV, and SHIV in luciferase reporter gene assays.
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Ex vivo adenovirus-mediated gene transfer to the adult rat heart.
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Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs.
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Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells.
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Extracellular low pH affects circadian rhythm expression in human primary fibroblasts.
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Female steroid hormones use signal transducers and activators of transcription protein-mediated pathways to modulate the expression of T-bet in epithelial cells: a mechanism for local immune regulation in the human reproductive tract.
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Formulations which increase the size of lipoplexes prevent serum-associated inhibition of transfection.
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Functional analysis of intra-allelic variation at NACP-Rep1 in the alpha-synuclein gene.
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Gamma-globin gene promoter elements required for interaction with globin enhancers.
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Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns.
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Genomic structure and embryonic expression of estrogen receptor beta a (ERbetaa) in zebrafish (Danio rerio).
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Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation.
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High intensity focused ultrasound-induced gene activation in solid tumors.
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How petals change their spots: cis-regulatory re-wiring in Clarkia (Onagraceae).
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Human T-cell leukemia virus type 1 Tax activates cyclin-dependent kinase inhibitor p21/Waf1/Cip1 expression through a p53-independent mechanism: Inhibition of cdk2.
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Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing.
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Human olfactory receptor responses to odorants.
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Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function.
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Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1.
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Human topoisomerase I promotes HIV-1 proviral DNA synthesis: implications for the species specificity and cellular tropism of HIV-1 infection.
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Hypermethylation of growth arrest DNA damage-inducible gene 45 beta promoter in human hepatocellular carcinoma.
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Hypoxia-regulated therapeutic gene as a preemptive treatment strategy against ischemia/reperfusion tissue injury.
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Identification of an enhancer element in the estrogen receptor upstream region: implications for regulation of ER transcription in breast cancer.
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Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1.
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In vivo bioluminescent imaging of influenza a virus infection and characterization of novel cross-protective monoclonal antibodies.
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In vivo regulation of hTERT expression and telomerase activity by androgen.
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Induction of nuclear factor kappaB by the CD30 receptor is mediated by TRAF1 and TRAF2.
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Inhibition of constitutive NF-kappa B activity by I kappa B alpha M suppresses tumorigenesis.
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Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway.
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Interaction of the Dr1 inhibitory factor with the TATA binding protein is disrupted by adenovirus E1A.
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Introduction of foreign genes into tissues of living mice by DNA-coated microprojectiles.
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Involvement of the mt1 melatonin receptor in human breast cancer.
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Lefty inhibits receptor-regulated Smad phosphorylation induced by the activated transforming growth factor-beta receptor.
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Ligand-specific dynamics of the androgen receptor at its response element in living cells.
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Loss of type III transforming growth factor-beta receptor expression is due to methylation silencing of the transcription factor GATA3 in renal cell carcinoma.
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Low-amplitude ultrasound enhances hydrodynamic-based gene delivery to rat kidney.
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Luminopsins integrate opto- and chemogenetics by using physical and biological light sources for opsin activation.
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Maspin expression profile in human prostate cancer (CaP) and in vitro induction of Maspin expression by androgen ablation.
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MeCP2 reinforces STAT3 signaling and the generation of effector CD4+ T cells by promoting miR-124-mediated suppression of SOCS5.
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Measuring HIV neutralization in a luciferase reporter gene assay.
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Mechanical Stability of a Small, Highly-Luminescent Engineered Protein NanoLuc.
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Methylation of TFPI-2 gene is not the sole cause of its silencing.
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MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms.
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Minimal and inducible regulation of tissue factor pathway inhibitor-2 in human gliomas.
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Molecular recognition of ketamine by a subset of olfactory G protein-coupled receptors.
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Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer.
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Myosin light chain-2 luciferase transgenic mice reveal distinct regulatory programs for cardiac and skeletal muscle-specific expression of a single contractile protein gene.
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Naked DNA delivered intraportally expresses efficiently in hepatocytes.
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Newspapers and newspaper ink contain agonists for the ah receptor.
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Noninvasive imaging and quantification of epidermal growth factor receptor kinase activation in vivo.
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Noninvasive visualization of retinoblastoma growth and metastasis via bioluminescence imaging.
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Novel integrase-defective lentiviral episomal vectors for gene transfer.
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Novel luciferase-based reporter system to monitor activation of ErbB2/Her2/neu pathway noninvasively during radiotherapy.
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Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis.
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Nucleotide excision repair as a marker for susceptibility to tobacco-related cancers: a review of molecular epidemiological studies.
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Odor coding by a Mammalian receptor repertoire.
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Parathyroid hormone-related peptide represses chondrocyte hypertrophy through a protein phosphatase 2A/histone deacetylase 4/MEF2 pathway.
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Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.
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Periodic root branching in Arabidopsis requires synthesis of an uncharacterized carotenoid derivative.
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Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling.
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Piecewise All-Atom SMD Simulations Reveal Key Secondary Structures in Luciferase Unfolding Pathway.
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Posttranscriptional regulation of protein expression in human epithelial carcinoma cells by adenine-uridine-rich elements in the 3'-untranslated region of tumor necrosis factor-alpha messenger RNA.
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Precise arrangement of factor-binding sites is required for murine CD4 promoter function.
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Problems for risk assessment of endocrine-active estrogenic compounds.
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Prolactin induction of insulin gene expression: the roles of glucose and glucose transporter-2.
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Prostaglandin A1 inhibits stress-induced NF-kappaB activation and reverses resistance to topoisomerase II inhibitors.
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Protein kinase C zeta transactivates hypoxia-inducible factor alpha by promoting its association with p300 in renal cancer.
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Pseudotyped viruses permit rapid detection of neutralizing antibodies in human and equine serum against Venezuelan equine encephalitis virus.
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Quantitative, noninvasive imaging of radiation-induced DNA double-strand breaks in vivo.
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Rapid assessment of repair of ultraviolet DNA damage with a modified host-cell reactivation assay using a luciferase reporter gene and correlation with polymorphisms of DNA repair genes in normal human lymphocytes.
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Rapid selection of tetracycline-controlled inducible cell lines using a green fluorescent-transactivator fusion protein.
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Recent advances in the characterization of HIV-1 neutralization assays for standardized evaluation of the antibody response to infection and vaccination.
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Regulation of E2A activities by histone acetyltransferases in B lymphocyte development.
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Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications.
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Regulation of casein kinase I epsilon activity by Wnt signaling.
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Repair of mitomycin C cross-linked DNA in mammalian cells measured by a host cell reactivation assay.
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Requirement for Abl kinases in T cell receptor signaling.
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Role for ETS domain transcription factors Pea3/Erm in mouse lung development.
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Role for hedgehog signaling in hepatic stellate cell activation and viability.
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Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes.
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Sequence requirements for micro RNA processing and function in human cells.
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Sonic hedgehog signaling pathway supports cancer cell growth during cancer radiotherapy.
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Split luciferase complementation assay for the analysis of G protein-coupled receptor ligand response in Saccharomyces cerevisiae.
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Suppression of pancreatic tumor progression by systemic delivery of a pancreatic-cancer-specific promoter driven Bik mutant.
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Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cells.
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Surface modified poly(β amino ester)-containing nanoparticles for plasmid DNA delivery.
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Synergistic and tunable human gene activation by combinations of synthetic transcription factors.
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Systemic dissemination of viral vectors during intratumoral injection.
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Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.
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The C-terminal domain of A1/Bfl-1 regulates its anti-inflammatory function in human endothelial cells.
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The MEK pathway is required for stimulation of p21(WAF1/CIP1) by transforming growth factor-beta.
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The insecticide synergist piperonyl butoxide inhibits hedgehog signaling: assessing chemical risks.
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The need for enhancers in gene expression first appears during mouse development with formation of the zygotic nucleus.
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The type III transforming growth factor-beta receptor negatively regulates nuclear factor kappa B signaling through its interaction with beta-arrestin2.
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Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome.
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Tolfenamic acid and pancreatic cancer growth, angiogenesis, and Sp protein degradation.
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Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3.
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Transcriptional regulation of the human alpha1a-adrenergic receptor gene. Characterization Of the 5'-regulatory and promoter region.
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Transfection efficiency and transgene expression kinetics of mRNA delivered in naked and nanoparticle format.
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Two and three-dimensional gene transfer from enzymatically degradable hydrogel scaffolds
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Use of bacterial quorum-sensing components to regulate gene expression in plants.
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Use of bioluminescence imaging to detect enhanced hepatic and systemic tumor growth following partial hepatectomy in mice.
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Use of in vivo bioluminescence imaging to predict hepatic tumor burden in mice.
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Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein.
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Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice.
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WT1 and DAX-1 inhibit aromatase P450 expression in human endometrial and endometriotic stromal cells.
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WT1 and Sox11 regulate synergistically the promoter of the Wnt4 gene that encodes a critical signal for nephrogenesis.
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zebraflash transgenic lines for in vivo bioluminescence imaging of stem cells and regeneration in adult zebrafish.
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Keywords of People
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Choi, Steven Sok,
Associate Professor of Medicine,
Medicine, Gastroenterology
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Hogan, Brigid L. M.,
Research Professor of Cell Biology,
Cell Biology
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Luftig, Micah Alan,
Associate Professor of Molecular Genetics and Microbiology,
Cell Biology
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Milano, Carmelo Alessio,
Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery,
Surgery, Cardiovascular and Thoracic Surgery