Lymphocyte Depletion
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Subject Areas on Research
- A double-blind, placebo-controlled study of anti-CD5 immunoconjugate in patients with rheumatoid arthritis. The Xoma RA Investigator Group.
- A large-scale method for the selective depletion of alphabeta T lymphocytes from PBSC for allogeneic transplantation.
- A one-step large-scale method for T- and B-cell depletion of mobilized PBSC for allogeneic transplantation.
- A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses.
- Active immunization using dendritic cells mixed with tumor cells inhibits the growth of primary breast cancer.
- Acute and chronic B cell depletion disrupts CD4+ and CD8+ T cell homeostasis and expansion during acute viral infection in mice.
- Acute graft-versus-host disease: are we close to bringing the bench to the bedside?
- Acute graft-vs-host disease: pathobiology and management.
- Addition of a second, different allogeneic graft accelerates white cell and platelet engraftment after T-cell-depleted bone marrow transplantation.
- Advances in the understanding and treatment of human severe combined immunodeficiency.
- Allogeneic hematopoietic stem cell transplant using mismatched/haploidentical donors.
- Alternate donor hematopoietic cell transplantation (HCT) in non-Hodgkin lymphoma using lower intensity conditioning: a report from the CIBMTR.
- Analysis of primate renal allografts after T-cell depletion with anti-CD3-CRM9.
- Anti-glycoprotein D monoclonal antibody protects against herpes simplex virus type 1-induced diseases in mice functionally depleted of selected T-cell subsets or asialo GM1+ cells.
- Antibody isotype-specific engagement of Fcgamma receptors regulates B lymphocyte depletion during CD20 immunotherapy.
- Antibody to the gp120 V1/V2 loops and CD4+ and CD8+ T cell responses in protection from SIVmac251 vaginal acquisition and persistent viremia.
- B cell depletion delays collagen-induced arthritis in mice: arthritis induction requires synergy between humoral and cell-mediated immunity.
- B cell depletion reduces the development of atherosclerosis in mice.
- B cells contribute to ischemia/reperfusion-mediated tissue injury.
- B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies.
- B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in Fc gamma R effector functions.
- B lymphocytes differentially influence acute and chronic allograft rejection in mice.
- B-lymphocyte contributions to human autoimmune disease.
- B-lymphocyte depletion ameliorates Sjögren's syndrome in Id3 knockout mice.
- B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis.
- BLyS levels correlate with vaccine-induced antibody titers in patients with glioblastoma lymphodepleted by therapeutic temozolomide.
- CD19: a promising B cell target for rheumatoid arthritis.
- CD4+ CD25+ FOXP3+ regulatory T cells increase de novo in kidney transplant patients after immunodepletion with Campath-1H.
- Campath-1H use in pediatric renal transplantation.
- Challenges in the pursuit of immune tolerance.
- Clinical trials: where are we now?
- Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes.
- Definition of a novel cellular constituent of the bone marrow that regulates the response of immature B cells to B cell antigen receptor engagement.
- Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines.
- Depletion of human regulatory T cells.
- Depletion of passenger leukocytes from corneal grafts: an effective means of promoting transplant survival?
- Development of tolerogenic strategies in the clinic.
- Dissociation of depletional induction and posttransplant lymphoproliferative disease in kidney recipients treated with alemtuzumab.
- Donor specific bone marrow cells suppress lymphocyte reactivity to donor antigens and differentially modulate TH1 and TH2 cytokine gene expression in the responder cell population.
- Donor type natural killer cells after haploidentical T cell-depleted bone marrow stem cell transplantation in a patient with adenosine deaminase-deficient severe combined immunodeficiency.
- EGFRvIII-targeted immunotoxin induces antitumor immunity that is inhibited in the absence of CD4+ and CD8+ T cells.
- Effect of CD8+ lymphocyte depletion on virus containment after simian immunodeficiency virus SIVmac251 challenge of live attenuated SIVmac239delta3-vaccinated rhesus macaques.
- Effect of anti-CD4 antibody treatment on inflammatory arthritis in MRL-lpr/lpr mice.
- Efficacy and toxicity of 9-beta-D-arabinofuranosylguanine (araG) as an agent to purge malignant T cells from murine bone marrow: application to an in vivo T-leukemia model.
- Elimination of clonogenic malignant human T cells using monoclonal antibodies in combination with 2'-deoxycoformycin.
- Emergence of simian immunodeficiency virus-specific cytotoxic CD4+ T cells and increased humoral responses correlate with control of rebounding viremia in CD8-depleted macaques infected with Rev-independent live-attenuated simian immunodeficiency virus.
- Enhanced de novo alloantibody and antibody-mediated injury in rhesus macaques.
- Evaluation of CD8+ T-cell and antibody responses following transient increased viraemia in rhesus macaques infected with live, attenuated simian immunodeficiency virus.
- Evaluation of a CD5-specific immunotoxin for treatment of acute graft-versus-host disease after allogeneic marrow transplantation.
- Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes.
- Evidence for susceptibility of intrathymic T-cell precursors and their progeny carrying T-cell antigen receptor phenotypes TCR alpha beta + and TCR gamma delta + to human immunodeficiency virus infection: a mechanism for CD4+ (T4) lymphocyte depletion.
- Expansion/deletion of mature T cells exposed to endogenous superantigens in vivo.
- FN18-CRM9 immunotoxin promotes tolerance in primate renal allografts.
- Fcgamma receptor-dependent effector mechanisms regulate CD19 and CD20 antibody immunotherapies for B lymphocyte malignancies and autoimmunity.
- Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells.
- Good and bad memories following rituximab therapy.
- Growth hormone accelerates immune recovery following allogeneic T-cell-depleted bone marrow transplantation in mice.
- Hematopoietic chimerism achieved by in utero hematopoietic stem cell injection does not induce donor-specific tolerance for renal allografts in sheep.
- Hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency.
- Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation.
- IL-2 receptor-targeted cytolytic IL-2/Fc fusion protein treatment blocks diabetogenic autoimmunity in nonobese diabetic mice.
- Inhibition of adaptive immune responses leads to a fatal clinical outcome in SIV-infected pigtailed macaques but not vervet African green monkeys.
- Knowledge about transplantation tolerance gained in primates.
- Limited contribution of humoral immunity to the clearance of measles viremia in rhesus monkeys.
- Lymphodepletional strategies in transplantation.
- Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage FcgammaRI, FcgammaRIII, and FcgammaRIV.
- Maintenance of long-lived plasma cells and serological memory despite mature and memory B cell depletion during CD20 immunotherapy in mice.
- Mechanisms of tolerance induced by an immunotoxin against CD3 epsilon in a rhesus kidney allograft model.
- Metastable tolerance in nonhuman primates and humans.
- Monoclonal antibody blockade of IL-2 receptor α during lymphopenia selectively depletes regulatory T cells in mice and humans.
- Myeloablative temozolomide enhances CD8⁺ T-cell responses to vaccine and is required for efficacy against brain tumors in mice.
- Neutralizing BAFF/APRIL with atacicept prevents early DSA formation and AMR development in T cell depletion induced nonhuman primate AMR model.
- Neutralizing antibodies as a potential secondary protective mechanism during chronic SHIV infection in CD8+ T-cell-depleted macaques.
- Normal human bone marrow precursors that express terminal deoxynucleotidyl transferase include T-cell precursors and possible lymphoid stem cells.
- PD-L1 serves as a double agent in separating GVL from GVHD.
- Photoinactivation of lymphohemopoietic cells: studies in transfusion medicine and bone marrow transplantation.
- Plasma therapy in immunodeficiency diseases.
- Post-transplantation B cell function in different molecular types of SCID.
- Postdepletion Lymphocyte Reconstitution During Belatacept and Rapamycin Treatment in Kidney Transplant Recipients.
- Preclinical evaluation of tolerance induction protocols and islet transplantation in non-human primates.
- Prevention of graft-versus-host disease while preserving graft-versus-leukemia effect after selective depletion of host-reactive T cells by photodynamic cell purging process.
- Prevention trumps treatment of antibody-mediated transplant rejection.
- Primate renal transplants using immunotoxin.
- Protective and pathogenic roles for B cells during systemic autoimmunity in NZB/W F1 mice.
- Rapid immune reconstitution after a reduced-intensity conditioning regimen and a CD3-depleted haploidentical stem cell graft for paediatric refractory haematological malignancies.
- Regulatory B cell (B10 Cell) expansion during Listeria infection governs innate and cellular immune responses in mice.
- Regulatory B cell production of IL-10 inhibits lymphoma depletion during CD20 immunotherapy in mice.
- Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression.
- Results from a human renal allograft tolerance trial evaluating T-cell depletion with alemtuzumab combined with deoxyspergualin.
- Results from a human renal allograft tolerance trial evaluating the humanized CD52-specific monoclonal antibody alemtuzumab (CAMPATH-1H).
- Reversal of acute allograft rejection using immunotoxin.
- Role of CD8(+) lymphocytes in control and clearance of measles virus infection of rhesus monkeys.
- Selective elimination of alloreactivity from immunotherapeutic T cells by photodynamic cell purging and memory T-cell sorting.
- Stem cell transplantation for the treatment of Fanconi anaemia using a fludarabine-based cytoreductive regimen and T-cell-depleted related HLA-mismatched peripheral blood stem cell grafts.
- Studies using a viral challenge and CD8 T cell depletions on the roles of cellular and humoral immunity in the control of an SHIV-89.6P challenge in DNA/MVA-vaccinated macaques.
- Suppression of adaptive immune responses during primary SIV infection of sabaeus African green monkeys delays partial containment of viremia but does not induce disease.
- Surrogate tolerogenesis: possible pretransplant induction of accommodation of pig xenografts.
- T cell depletion increases susceptibility to murine cytomegalovirus retinitis.
- T-lymphocyte alloresponses of Campath-1H-treated kidney transplant patients.
- Targeting B-cells mitigates autoimmune diabetes in NOD mice: what is plan B?
- Targeting molecular and cellular inhibitory mechanisms for improvement of antitumor memory responses reactivated by tumor cell vaccine.
- The BB diabetic rat. Profound T-cell lymphocytopenia.
- The effect of natural killer cell killer Ig-like receptor alloreactivity on the outcome of bone marrow stem cell transplantation for severe combined immunodeficiency (SCID).
- The effect of xenoreactive antibody and B cell depletion on hyperacute rejection of guinea pig-to-rat cardiac xenografts.
- The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy.
- The peritoneal cavity provides a protective niche for B1 and conventional B lymphocytes during anti-CD20 immunotherapy in mice.
- The road to tolerance: renal transplant tolerance induction in nonhuman primate studies and clinical trials.
- Tolerance and near-tolerance strategies in monkeys and their application to human renal transplantation.
- Toll-like receptors in tumor immunotherapy.
- Treatment of chronic granulomatous disease with nonmyeloablative conditioning and a T-cell-depleted hematopoietic allograft.
- Tumor recognition and lytic competence of IL-2-activated lymphocytes: regulation of both antibody-independent and -dependent cellular cytotoxicity via P75 IL-2 receptor.
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Keywords of People
- Chen, Jun, Associate Professor of Medicine, Duke Cancer Institute
- McLendon, Roger Edwin, Professor of Pathology, Pathology
- Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Immunology
- Yang, Yiping, Professor of Medicine, Immunology