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Subject Areas on Research
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A closer look at rituximab induction on HLA antibody rebound following HLA-incompatible kidney transplantation.
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A double-blind, placebo-controlled study of anti-CD5 immunoconjugate in patients with rheumatoid arthritis. The Xoma RA Investigator Group.
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A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses.
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Active immunization using dendritic cells mixed with tumor cells inhibits the growth of primary breast cancer.
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Acute and chronic B cell depletion disrupts CD4+ and CD8+ T cell homeostasis and expansion during acute viral infection in mice.
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Acute graft-versus-host disease: are we close to bringing the bench to the bedside?
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Acute graft-vs-host disease: pathobiology and management.
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Addition of a second, different allogeneic graft accelerates white cell and platelet engraftment after T-cell-depleted bone marrow transplantation.
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Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens.
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Advances in the understanding and treatment of human severe combined immunodeficiency.
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Allogeneic hematopoietic stem cell transplant using mismatched/haploidentical donors.
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Analysis of primate renal allografts after T-cell depletion with anti-CD3-CRM9.
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Anti-glycoprotein D monoclonal antibody protects against herpes simplex virus type 1-induced diseases in mice functionally depleted of selected T-cell subsets or asialo GM1+ cells.
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Antibody isotype-specific engagement of Fcgamma receptors regulates B lymphocyte depletion during CD20 immunotherapy.
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Antibody to the gp120 V1/V2 loops and CD4+ and CD8+ T cell responses in protection from SIVmac251 vaginal acquisition and persistent viremia.
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Antibody-Mediated Rejection in Sensitized Nonhuman Primates: Modeling Human Biology.
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Antiviral antibodies are necessary for control of simian immunodeficiency virus replication.
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Appearance of multiple benign paraproteins during early engraftment of soy lectin T cell-depleted haploidentical bone marrow cells in severe combined immunodeficiency.
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Autoimmune thyroid disease after renal transplantation using depletional induction with alemtuzumab.
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B cell depletion delays collagen-induced arthritis in mice: arthritis induction requires synergy between humoral and cell-mediated immunity.
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B cell depletion in HIV-1 subtype A infected Ugandan adults: relationship to CD4 T cell count, viral load and humoral immune responses.
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B cell depletion reduces the development of atherosclerosis in mice.
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B cells contribute to ischemia/reperfusion-mediated tissue injury.
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B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies.
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B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in Fc gamma R effector functions.
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B lymphocytes differentially influence acute and chronic allograft rejection in mice.
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B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction.
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B-lymphocyte contributions to human autoimmune disease.
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B-lymphocyte depletion ameliorates Sjögren's syndrome in Id3 knockout mice.
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B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis.
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BLyS levels correlate with vaccine-induced antibody titers in patients with glioblastoma lymphodepleted by therapeutic temozolomide.
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CD19: a promising B cell target for rheumatoid arthritis.
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CD4+ CD25+ FOXP3+ regulatory T cells increase de novo in kidney transplant patients after immunodepletion with Campath-1H.
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Calcium/Calmodulin Dependent Protein Kinase Kinase 2 Regulates the Expansion of Tumor-Induced Myeloid-Derived Suppressor Cells.
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Campath-1H use in pediatric renal transplantation.
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Challenges in the pursuit of immune tolerance.
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Clinical trials: where are we now?
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Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes.
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Crossing the bridge: large animal models in translational transplantation research.
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Definition of a novel cellular constituent of the bone marrow that regulates the response of immature B cells to B cell antigen receptor engagement.
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Depletion of host reactive T cells by photodynamic cell purging and prevention of graft versus host disease.
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Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines.
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Depletion of human regulatory T cells.
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Depletion of passenger leukocytes from corneal grafts: an effective means of promoting transplant survival?
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Development of tolerogenic strategies in the clinic.
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Differential reconstitution of T cell subsets following immunodepleting treatment with alemtuzumab (anti-CD52 monoclonal antibody) in patients with relapsing-remitting multiple sclerosis.
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Dissociation of depletional induction and posttransplant lymphoproliferative disease in kidney recipients treated with alemtuzumab.
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Donor specific bone marrow cells suppress lymphocyte reactivity to donor antigens and differentially modulate TH1 and TH2 cytokine gene expression in the responder cell population.
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Donor type natural killer cells after haploidentical T cell-depleted bone marrow stem cell transplantation in a patient with adenosine deaminase-deficient severe combined immunodeficiency.
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EGFRvIII-targeted immunotoxin induces antitumor immunity that is inhibited in the absence of CD4+ and CD8+ T cells.
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Effect of Alemtuzumab (CAMPATH 1-H) in patients with inclusion-body myositis.
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Effect of B-cell depletion on viral replication and clinical outcome of simian immunodeficiency virus infection in a natural host.
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Effect of CD8+ lymphocyte depletion on virus containment after simian immunodeficiency virus SIVmac251 challenge of live attenuated SIVmac239delta3-vaccinated rhesus macaques.
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Effect of CXCL-1/KC production in high risk vascularized corneal allografts on T cell recruitment and graft rejection.
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Effect of anti-CD4 antibody treatment on inflammatory arthritis in MRL-lpr/lpr mice.
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Efficacy and toxicity of 9-beta-D-arabinofuranosylguanine (araG) as an agent to purge malignant T cells from murine bone marrow: application to an in vivo T-leukemia model.
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Elimination of clonogenic malignant human T cells using monoclonal antibodies in combination with 2'-deoxycoformycin.
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Emergence of simian immunodeficiency virus-specific cytotoxic CD4+ T cells and increased humoral responses correlate with control of rebounding viremia in CD8-depleted macaques infected with Rev-independent live-attenuated simian immunodeficiency virus.
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Emerging New Approaches in Desensitization: Targeted Therapies for HLA Sensitization.
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Enhanced de novo alloantibody and antibody-mediated injury in rhesus macaques.
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Evaluation of CD8+ T-cell and antibody responses following transient increased viraemia in rhesus macaques infected with live, attenuated simian immunodeficiency virus.
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Evaluation of a CD5-specific immunotoxin for treatment of acute graft-versus-host disease after allogeneic marrow transplantation.
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Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes.
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Evidence for susceptibility of intrathymic T-cell precursors and their progeny carrying T-cell antigen receptor phenotypes TCR alpha beta + and TCR gamma delta + to human immunodeficiency virus infection: a mechanism for CD4+ (T4) lymphocyte depletion.
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FN18-CRM9 immunotoxin promotes tolerance in primate renal allografts.
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Fcgamma receptor-dependent effector mechanisms regulate CD19 and CD20 antibody immunotherapies for B lymphocyte malignancies and autoimmunity.
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Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells.
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Good and bad memories following rituximab therapy.
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Graft failure in patients receiving T cell-depleted HLA-identical allogeneic marrow transplants.
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Granulocytes act as a niche for Mycobacterium tuberculosis growth.
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Growth hormone accelerates immune recovery following allogeneic T-cell-depleted bone marrow transplantation in mice.
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HLA-identical marrow transplantation during accelerated-phase chronic myelogenous leukemia: analysis of survival and remission duration.
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Hematopoietic chimerism achieved by in utero hematopoietic stem cell injection does not induce donor-specific tolerance for renal allografts in sheep.
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Hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency.
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Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation.
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Homeostatic proliferation plus regulatory T-cell depletion promotes potent rejection of B16 melanoma.
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IL-7 receptor heterogeneity as a mechanism for repertoire change during postdepletional homeostatic proliferation and its relation to costimulation blockade-resistant rejection.
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Immune failure in the absence of profound CD4+ T-lymphocyte depletion in simian immunodeficiency virus-infected rapid progressor macaques.
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Impaired bone marrow B-cell development in mice with a bronchiolitis obliterans model of cGVHD.
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Impaired lymphocyte transformation in Hodgkin's disease. Evidence for depletion of circulating t-lymphocytes.
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Inhibition of adaptive immune responses leads to a fatal clinical outcome in SIV-infected pigtailed macaques but not vervet African green monkeys.
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Is tolerance induction the answer to adolescent non-adherence?
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Knowledge about transplantation tolerance gained in primates.
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Limited ability of humoral immune responses in control of viremia during infection with SIVsmmD215 strain.
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Long-term follow-up of T cell-depleted allogeneic bone marrow transplantation in refractory multiple myeloma: importance of allogeneic T cells.
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Long-term outcomes of nonconditioned patients with severe combined immunodeficiency transplanted with HLA-identical or haploidentical bone marrow depleted of T cells with anti-CD6 mAb.
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Lymphocyte depletion and risk of acute rejection in renal transplant recipients at increased risk for delayed graft function.
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Lymphocytic Choriomeningitis Virus Expands a Population of NKG2D+CD8+ T Cells That Exacerbates Disease in Mice Coinfected with Leishmania major.
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Lymphodepletional strategies in transplantation.
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Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage FcgammaRI, FcgammaRIII, and FcgammaRIV.
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Maintenance of long-lived plasma cells and serological memory despite mature and memory B cell depletion during CD20 immunotherapy in mice.
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Mechanisms of tolerance induced by an immunotoxin against CD3 epsilon in a rhesus kidney allograft model.
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Metastable tolerance in nonhuman primates and humans.
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Monkeying Around: Using Non-human Primate Models to Study NK Cell Biology in HIV Infections.
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Monoclonal antibody blockade of IL-2 receptor α during lymphopenia selectively depletes regulatory T cells in mice and humans.
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Myeloablative temozolomide enhances CD8⁺ T-cell responses to vaccine and is required for efficacy against brain tumors in mice.
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Neutralizing BAFF/APRIL with atacicept prevents early DSA formation and AMR development in T cell depletion induced nonhuman primate AMR model.
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Neutralizing antibodies as a potential secondary protective mechanism during chronic SHIV infection in CD8+ T-cell-depleted macaques.
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Normal human bone marrow precursors that express terminal deoxynucleotidyl transferase include T-cell precursors and possible lymphoid stem cells.
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Photoinactivation of lymphohemopoietic cells: studies in transfusion medicine and bone marrow transplantation.
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Plasma therapy in immunodeficiency diseases.
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Post-transplantation B cell function in different molecular types of SCID.
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Postdepletion Lymphocyte Reconstitution During Belatacept and Rapamycin Treatment in Kidney Transplant Recipients.
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Preclinical evaluation of tolerance induction protocols and islet transplantation in non-human primates.
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Prevention of graft-versus-host disease while preserving graft-versus-leukemia effect after selective depletion of host-reactive T cells by photodynamic cell purging process.
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Prevention trumps treatment of antibody-mediated transplant rejection.
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Primate renal transplants using immunotoxin.
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Protective and pathogenic roles for B cells during systemic autoimmunity in NZB/W F1 mice.
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Rapamycin Interferes With Postdepletion Regulatory T Cell Homeostasis and Enhances DSA Formation Corrected by CTLA4-Ig.
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Recollective homeostasis and the immune consequences of peritransplant depletional induction therapy.
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Regulatory B cell (B10 Cell) expansion during Listeria infection governs innate and cellular immune responses in mice.
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Regulatory B cell production of IL-10 inhibits lymphoma depletion during CD20 immunotherapy in mice.
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Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression.
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Results from a human renal allograft tolerance trial evaluating T-cell depletion with alemtuzumab combined with deoxyspergualin.
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Results from a human renal allograft tolerance trial evaluating the humanized CD52-specific monoclonal antibody alemtuzumab (CAMPATH-1H).
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Reversal of acute allograft rejection using immunotoxin.
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Risk of lymphoproliferative disorders after bone marrow transplantation: a multi-institutional study.
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Selective elimination of alloreactivity from immunotherapeutic T cells by photodynamic cell purging and memory T-cell sorting.
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Stem cell transplantation for the treatment of Fanconi anaemia using a fludarabine-based cytoreductive regimen and T-cell-depleted related HLA-mismatched peripheral blood stem cell grafts.
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Studies using a viral challenge and CD8 T cell depletions on the roles of cellular and humoral immunity in the control of an SHIV-89.6P challenge in DNA/MVA-vaccinated macaques.
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Suppression of adaptive immune responses during primary SIV infection of sabaeus African green monkeys delays partial containment of viremia but does not induce disease.
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Surrogate tolerogenesis: possible pretransplant induction of accommodation of pig xenografts.
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T cell depletion increases susceptibility to murine cytomegalovirus retinitis.
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T-lymphocyte alloresponses of Campath-1H-treated kidney transplant patients.
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Targeted and untargeted CD137L fusion proteins for the immunotherapy of experimental solid tumors.
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Targeting B-cells mitigates autoimmune diabetes in NOD mice: what is plan B?
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Targeting molecular and cellular inhibitory mechanisms for improvement of antitumor memory responses reactivated by tumor cell vaccine.
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The BB diabetic rat. Profound T-cell lymphocytopenia.
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The cam-path forward.
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The effect of natural killer cell killer Ig-like receptor alloreactivity on the outcome of bone marrow stem cell transplantation for severe combined immunodeficiency (SCID).
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The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy.
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The peritoneal cavity provides a protective niche for B1 and conventional B lymphocytes during anti-CD20 immunotherapy in mice.
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The risk and opportunity of homeostatic repopulation.
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The road to tolerance: renal transplant tolerance induction in nonhuman primate studies and clinical trials.
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The role of alemtuzumab in facilitating maintenance immunosuppression minimization following solid organ transplantation.
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Tolerance and near-tolerance strategies in monkeys and their application to human renal transplantation.
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Tolerance: is it achievable in pediatric solid organ transplantation?
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Transfer of specific immunity in marrow recipients given HLA-mismatched, T cell-depleted, or HLA-identical marrow grafts.
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Treatment of chronic granulomatous disease with nonmyeloablative conditioning and a T-cell-depleted hematopoietic allograft.
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Tumor recognition and lytic competence of IL-2-activated lymphocytes: regulation of both antibody-independent and -dependent cellular cytotoxicity via P75 IL-2 receptor.
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Viral infection abrogates CD8(+) T-cell deletion induced by costimulation blockade.
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Keywords of People
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Chen, Jun,
Professor of Medicine,
Duke Cancer Institute
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McLendon, Roger Edwin,
Professor of Pathology,
Pathology
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Sampson, John Howard,
Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine,
Biomedical Engineering