Lymphocyte Activation

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  Subject Areas on Research

  • 4-Quinolone drugs affect cell cycle progression and function of human lymphocytes in vitro. 
  • A CD91-positive subset of CD11c+ blood dendritic cells: characterization of the APC that functions to enhance adaptive immune responses against CD91-targeted antigens. 
  • A Distinct Function of Regulatory T Cells in Tissue Protection. 
  • A Phase I safety and immunogenicity trial of UBI microparticulate monovalent HIV-1 MN oral peptide immunogen with parenteral boost in HIV-1 seronegative human subjects. 
  • A Rationally Designed Fully Human EGFRvIII:CD3-Targeted Bispecific Antibody Redirects Human T Cells to Treat Patient-derived Intracerebral Malignant Glioma. 
  • A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice. 
  • A c-Myc and surface CD19 signaling amplification loop promotes B cell lymphoma development and progression in mice. 
  • A canarypox vaccine expressing multiple human immunodeficiency virus type 1 genes given alone or with rgp120 elicits broad and durable CD8+ cytotoxic T lymphocyte responses in seronegative volunteers. 
  • A case of atypical, complete DiGeorge syndrome without 22q11 mutation. 
  • A case report of clonal EBV-like memory CD4+ T cell activation in fatal checkpoint inhibitor-induced encephalitis. 
  • A closer look at rituximab induction on HLA antibody rebound following HLA-incompatible kidney transplantation. 
  • A controlled study of cellular immune function in affective disorders before and during somatic therapy. 
  • A critical precursor frequency of donor-reactive CD4+ T cell help is required for CD8+ T cell-mediated CD28/CD154-independent rejection. 
  • A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic. 
  • A highly polarized TH2 bladder response to infection promotes epithelial repair at the expense of preventing new infections. 
  • A modified host-cell reactivation assay to measure repair of alkylating DNA damage for assessing risk of lung adenocarcinoma. 
  • A neutralizing epitope of the superantigen SEA has agonist activity on T cells. 
  • A new look at blockade of T-cell costimulation: a therapeutic strategy for long-term maintenance immunosuppression. 
  • A novel activation pathway for mature thymocytes. Costimulation of CD2 (T,p50) and CD28 (T,p44) induces autocrine interleukin 2/interleukin 2 receptor-mediated cell proliferation. 
  • A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily. 
  • A novel method for detection and ex vivo expansion of HIV type 1-specific cytolytic T lymphocytes. 
  • A novel polypeptide secreted by activated human T lymphocytes. 
  • A nuclear factor-kappaB inhibitor BAY11-7082 inhibits interactions between human endothelial cells, T cells, and monocytes. 
  • A panel of MHC class I restricted viral peptides for use as a quality control for vaccine trial ELISPOT assays. 
  • A phase II study of two HIV type 1 envelope vaccines, comparing their immunogenicity in populations at risk for acquiring HIV type 1 infection. AIDS Vaccine Evaluation Group. 
  • A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone. 
  • A prospective study of squamous head and neck carcinoma. Immunologic aberrations in patients who develop recurrent disease. 
  • A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A. 
  • A single amino acid defines cross-species reactivity of tree shrew (Tupaia belangeri) CD1d to human invariant natural killer T (iNKT) cells. 
  • A single peptide-major histocompatibility complex ligand triggers digital cytokine secretion in CD4(+) T cells. 
  • A soluble inhibitor of T lymphocyte function induced by HIV-1 infection of CD4+ T cells: characterization of a cellular protein and its relationship to p15E. 
  • A synthetic peptide homologous to retroviral transmembrane envelope proteins depresses protein kinase C mediated lymphocyte proliferation and directly inactivated protein kinase C: a potential mechanism for immunosuppression. 
  • A synthetic random basic copolymer with promiscuous binding to class II major histocompatibility complex molecules inhibits T-cell proliferative responses to major and minor histocompatibility antigens in vitro and confers the capacity to prevent murine graft-versus-host disease in vivo. 
  • A tale of two TRAPs: LAT and LAB in the regulation of lymphocyte development, activation, and autoimmunity. 
  • ADAM metallopeptidase domain 17 (ADAM17) is naturally processed through major histocompatibility complex (MHC) class I molecules and is a potential immunotherapeutic target in breast, ovarian and prostate cancers. 
  • Aberrant B-cell homeostasis in chronic GVHD. 
  • Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell-like diffuse large B cell lymphoma. 
  • Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. 
  • Abnormalities of chemotactic lymphokine synthesis and mononuclear leukocyte chemotaxis in Wiskott-Aldrich syndrome. 
  • Accelerated development of immunity following transplantation of maternal marrow stem cells into infants with severe combined immunodeficiency and transplacentally acquired lymphoid chimerism. 
  • Accelerated induction of experimental allergic encephalomyelitis in PL/J mice by a non-V beta 8-specific superantigen. 
  • Activated B cells modified by electroporation of multiple mRNAs encoding immune stimulatory molecules are comparable to mature dendritic cells in inducing in vitro antigen-specific T-cell responses. 
  • Activated T lymphocytes regulate hyaluronan binding to monocyte CD44 via production of IL-2 and IFN-gamma. 
  • Activated lymphocytes promote endothelial cell detachment from matrix: a role for modulation of endothelial cell beta 1 integrin affinity. 
  • Activation of T lymphocytes for adhesion and cytokine expression by toxin-conjugated anti-CD3 monoclonal antibodies. 
  • Activation of human B cells by phosphorothioate oligodeoxynucleotides. 
  • Activation of human B lymphocytes. III. Concanavalin A-induced generation of suppressor cells of the plaque-forming cell response of normal human B lymphocytes. 
  • Activation of human B lymphocytes. V. Kinetics and mechanisms of suppression of plaque-forming cell responses by concanavalin A-generated suppressor cells. 
  • Activation of human B lymphocytes. VI. Immunoregulation of antibody production by mitogen-induced and naturally occurring cells in normal individuals. 
  • Activation of human B lymphocytes. XIII. Characterization of multiple populations of naturally occurring immunoregulatory cells of polyclonally induced in vitro human B cell function. 
  • Activation of human B lymphocytes. XIV. Characterization of the precursor of the pokeweed mitogen-induced anti-sheep red blood cell plaque-forming cell. 
  • Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors. 
  • Activation-induced cytidine deaminase expression and activity in the absence of germinal centers: insights into hyper-IgM syndrome. 
  • Activation-induced endocytosis of the raft-associated transmembrane adaptor protein LAB/NTAL in B lymphocytes: evidence for a role in internalization of the B cell receptor. 
  • Active lifestyle offsets HRT-induced suppression of T cell reactivity to mitogens. 
  • Acute graft-versus-host disease: are we close to bringing the bench to the bedside? 
  • Adaptor proteins in lymphocyte activation. 
  • Administration of a CD31-derived peptide delays the onset and significantly increases survival from lethal graft-versus-host disease. 
  • Adoptive transfer of cytotoxic T lymphocytes for the treatment of transplant-associated lymphoma. 
  • Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl. 
  • Age-related alterations in actin cytoskeleton and receptor expression in human leukocytes. 
  • Agent-based modeling of the context dependency in T cell recognition. 
  • Aging is associated with a rapid decline in frequency, alterations in subset composition, and enhanced Th2 response in CD1d-restricted NKT cells from human peripheral blood. 
  • Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity. 
  • Allo-Specific Humoral Responses: New Methods for Screening Donor-Specific Antibody and Characterization of HLA-Specific Memory B Cells. 
  • Allograft airway fibrosis in the pulmonary milieu: a disorder of tissue remodeling. 
  • Alloimmune lung injury induced by local innate immune activation through inhaled lipopolysaccharide. 
  • Alpha 2-macroglobulin binds CpG oligodeoxynucleotides and enhances their immunostimulatory properties by a receptor-dependent mechanism. 
  • Alpha-glycosylceramides enhance the antitumor cytotoxicity of hepatic lymphocytes obtained from cancer patients by activating CD3-CD56+ NK cells in vitro. 
  • Alpha-melanocyte-stimulating hormone suppresses antigen-stimulated T cell production of gamma-interferon. 
  • Alterations of the B-cell response by HIV-1 replication. 
  • Altered Maturation Status and Possible Immune Exhaustion of CD8 T Lymphocytes in the Peripheral Blood of Patients Presenting With Acute Coronary Syndromes. 
  • Altered T-dependent antigen responses and development of autoimmune symptoms in mice lacking E2A in T lymphocytes. 
  • Altered immune responses in apolipoprotein E-deficient mice. 
  • Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients. 
  • Altered lymphocyte populations in tumour invaded nodes of breast cancer patients. 
  • Amplification of suppressor inducer pathway with monoclonal antibody, anti-2H4, identifying a novel epitope of the common leukocyte antigen/T200 antigen. 
  • An EGFRvIII-targeted bispecific T-cell engager overcomes limitations of the standard of care for glioblastoma. 
  • An Engineered Tumor-on-a-Chip Device with Breast Cancer-Immune Cell Interactions for Assessing T-cell Recruitment. 
  • An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a. 
  • An env gene derived from a primary human immunodeficiency virus type 1 isolate confers high in vivo replicative capacity to a chimeric simian/human immunodeficiency virus in rhesus monkeys. 
  • An oxidative stress-based mechanism of doxorubicin cytotoxicity suggests new therapeutic strategies in ABC-DLBCL. 
  • Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal. 
  • Analysis of lymphocytic infiltration in uveal melanoma. 
  • Analysis of the expression of CD5 by human B cells and correlation with functional activity. 
  • Analysis of the immune responses in chimpanzees infected with HIV type 1 isolates. 
  • Analysis of the linker for activation of T cells and the linker for activation of B cells in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire. 
  • Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway. 
  • Angiotensin II: an immune costimulator? 
  • Anti-4-1BB immunotherapy enhances systemic immune effects of radiotherapy to induce B and T cell-dependent anti-tumor immune activation and improve tumor control at unirradiated sites. 
  • Antibodies against the CD44 p80, lymphocyte homing receptor molecule augment human peripheral blood T cell activation. 
  • Antibodies reactive with class II antigens encoded for by the major histocompatibility complex inhibit human B cell activation. 
  • Antibodies reactive with the B1 molecule inhibit cell cycle progression but not activation of human B lymphocytes. 
  • Antibody valence and induced signal transduction: the role of antibody valence in anti-CD3-induced signal transduction in isolated normal T cells. 
  • Antibody-selected mimics of hepatitis C virus hypervariable region 1 activate both primary and memory Th lymphocytes. 
  • Anticipatory immune suppression and nausea in women receiving cyclic chemotherapy for ovarian cancer. 
  • Antigen delivery by alpha(2)-macroglobulin enhances the cytotoxic T lymphocyte response. 
  • Antiretroviral therapy corrects HIV-1-induced expansion of CD8+ CD45RA+ CD2-) CD11a(bright) activated T cells. 
  • Antiretroviral therapy initiated during acute HIV infection fails to prevent persistent T-cell activation. 
  • Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis. 
  • Aqueous humor factors and their effect on the immune response in the anterior chamber. 
  • Attrition of memory CD8 T cells during sepsis requires LFA-1. 
  • Augmentation of syngeneic tumor-specific immunity by semiallogeneic cell hybrids. 
  • Autoimmune lymphoproliferative syndrome: an update and review of the literature. 
  • Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression. 
  • Autophagy regulates T lymphocyte proliferation through selective degradation of the cell-cycle inhibitor CDKN1B/p27Kip1. 
  • B Cell Subsets Differentially Contribute to the T Cell-Independent Memory Pool. 
  • B cell depletion reduces the development of atherosclerosis in mice. 
  • B cells are required for optimal CD4+ and CD8+ T cell tumor immunity: therapeutic B cell depletion enhances B16 melanoma growth in mice. 
  • B cells from patients with chronic GVHD are activated and primed for survival via BAFF-mediated pathways. 
  • B cells in chronic graft-versus-host disease. 
  • B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. 
  • B-cell differentiation and IL-21 response in IL2RG/JAK3 SCID patients after hematopoietic stem cell transplantation. 
  • B-lymphocyte contributions to human autoimmune disease. 
  • B-lymphocyte effector functions in health and disease. 
  • BAFF promotes heightened BCR responsiveness and manifestations of chronic GVHD after allogeneic stem cell transplantation. 
  • BCR and Endosomal TLR Signals Synergize to Increase AID Expression and Establish Central B Cell Tolerance. 
  • Biochemical Underpinnings of Immune Cell Metabolic Phenotypes. 
  • Bispecific antibodies engage T cells for antitumor immunotherapy. 
  • Blocking of autologous and homologous leukocyte responses by human alloimmune plasmas: a possible in vitro correlate of enhancement. 
  • Boosting with Subtype C CN54rgp140 Protein Adjuvanted with Glucopyranosyl Lipid Adjuvant after Priming with HIV-DNA and HIV-MVA Is Safe and Enhances Immune Responses: A Phase I Trial. 
  • Branhamella catarrhalis activates human B lymphocytes following interactions with surface IgD and class I major histocompatibility complex antigens. 
  • Bromelain treatment alters leukocyte expression of cell surface molecules involved in cellular adhesion and activation. 
  • Bromelain treatment of human T cells removes CD44, CD45RA, E2/MIC2, CD6, CD7, CD8, and Leu 8/LAM1 surface molecules and markedly enhances CD2-mediated T cell activation. 
  • Bronchus-associated lymphoid tissue-resident Foxp3+ T lymphocytes prevent antibody-mediated lung rejection. 
  • C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates. 
  • CALGB 150905 (Alliance): rituximab broadens the antilymphoma response by activating unlicensed NK cells. 
  • CCL5-mediated endogenous antitumor immunity elicited by adoptively transferred lymphocytes and dendritic cell depletion. 
  • CD154 blockade, sirolimus, and donor-specific transfusion prevents renal allograft rejection in cynomolgus monkeys despite homeostatic T-cell activation. 
  • CD161 contributes to prenatal immune suppression of IFNγ-producing PLZF+ T cells. 
  • CD19 amplification of B lymphocyte Ca2+ responses: a role for Lyn sequestration in extinguishing negative regulation. 
  • CD19 expression levels regulate B lymphocyte development: human CD19 restores normal function in mice lacking endogenous CD19. 
  • CD19 regulates B lymphocyte signaling thresholds critical for the development of B-1 lineage cells and autoimmunity. 
  • CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes. 
  • CD19, CD21, and CD22: multifaceted response regulators of B lymphocyte signal transduction. 
  • CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes. 
  • CD2-mediated IL-12-dependent signals render human gamma delta-T cells resistant to mitogen-induced apoptosis, permitting the large-scale ex vivo expansion of functionally distinct lymphocytes: implications for the development of adoptive immunotherapy strategies. 
  • CD22 cross-linking generates B-cell antigen receptor-independent signals that activate the JNK/SAPK signaling cascade. 
  • CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice. 
  • CD22 regulates B lymphocyte function in vivo through both ligand-dependent and ligand-independent mechanisms. 
  • CD22 regulates time course of both B cell division and antibody response. 
  • CD22-Binding Synthetic Sialosides Regulate B Lymphocyte Proliferation Through CD22 Ligand-Dependent and Independent Pathways, and Enhance Antibody Production in Mice. 
  • CD25+CD4+ regulatory T cell migration requires L-selectin expression: L-selectin transcriptional regulation balances constitutive receptor turnover. 
  • CD277 is a negative co-stimulatory molecule universally expressed by ovarian cancer microenvironmental cells. 
  • CD28 costimulatory signal induces protein arginine methylation in T cells. 
  • CD28 ligation induces rapid tyrosine phosphorylation of the linker molecule LAT in the absence of Syk and ZAP-70 tyrosine phosphorylation. 
  • CD28 ligation induces tyrosine phosphorylation of Pyk2 but not Fak in Jurkat T cells. 
  • CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival. 
  • CD34+CD38-lin- cord blood cells develop into dendritic cells in human thymic stromal monolayers and thymic nodules. 
  • CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse. 
  • CD4+ CD25+ FOXP3+ regulatory T cells increase de novo in kidney transplant patients after immunodepletion with Campath-1H. 
  • CD4+ T-cell and monocyte interdependence during discordant xenoimmune responses. 
  • CD4+Thy1- thymocytes with a Th-type 2 cytokine response. 
  • CD40 ligand (CD154) triggers a short-term CD4(+) T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis. 
  • CD44--a molecule involved in leukocyte adherence and T-cell activation. 
  • CD8 positive T cells influence antigen-specific immune responses through the expression of chemokines. 
  • CD8+ lymphocyte activation at human immunodeficiency virus type 1 seroconversion: development of HLA-DR+ CD38- CD8+ cells is associated with subsequent stable CD4+ cell levels. The Multicenter AIDS Cohort Study Group. 
  • CD83 expression is a sensitive marker of activation required for B cell and CD4+ T cell longevity in vivo. 
  • CD83 influences cell-surface MHC class II expression on B cells and other antigen-presenting cells. 
  • CD86 (B7-2) can function to drive MHC-restricted antigen-specific CTL responses in vivo. 
  • CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells. 
  • CTLA-4-Mediated inhibition of early events of T cell proliferation. 
  • CTLA4Ig: bridging the basic immunology with clinical application. 
  • CXCR3-mediated T-cell chemotaxis involves ZAP-70 and is regulated by signalling through the T-cell receptor. 
  • Calcineurin mutants render T lymphocytes resistant to cyclosporin A. 
  • Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation. 
  • Cancer immunotherapy innovator James Allison receives the 2015 Lasker~DeBakey Clinical Medical Research Award. 
  • Cancer vaccines in colon and rectal cancer over the last decade: lessons learned and future directions. 
  • Carbohydrate metabolism in transforming lymphocytes from the aged. 
  • Cellular adhesion and proliferative responses of neonatal human lymphocytes to pig endothelial cells. 
  • Cellular events in the differentiation of antibody-secreting cells. 
  • Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers. 
  • Challenges in therapeutic strategies for transplantation: where now from here? 
  • Changes in CD4+ T-cell differentiation phenotype during structured treatment interruption in patients with chronic HIV-1 infection. 
  • Characteristics of alloreactive rat T cell lines established from low and high rejecting orthotopic liver transplants. 
  • Characteristics of the specific cell-mediated immune response in human immunodeficiency virus infection. 
  • Characterization of a monoclonal antibody (4F2) that binds to human monocytes and to a subset of activated lymphocytes. 
  • Characterization of cytotoxic cells generated from in vitro cultures of murine bone marrow cells. 
  • Characterization of effector T cells in dry eye disease. 
  • Characterization of human CD7 transgenic mice. 
  • Characterization of human chemotactic lymphokine production induced by mitogens and mixed leukocyte reactions using a new microassay. 
  • Characterization of the effects of endotoxin on macrophage tumor cell killing. 
  • Characterization of the immune response to the major glycoprotein (gp 71) of Friend leukemia virus. I. Response in BALB/c mice. 
  • Characterization of the immune response to the major glycoprotein (gp71) of Friend leukemia virus. II. Response in C57BL/6 mice. 
  • Characterization of the immune response to the major glycoprotein (gp71) of Friend leukemia virus. III. Influence on endogenous MuLV-mediated pathogenesis. 
  • Characterization of tumor-specific cytotoxic effector cells with a novel CD3-/Thy-1+ phenotype. 
  • Checkpoint blockade in combination with cancer vaccines. 
  • Checkpoint inhibitors in hematological malignancies. 
  • Chronic Alcohol Ingestion Delays T Cell Activation and Effector Function in Sepsis. 
  • Chronic activation of the kinase IKKβ impairs T cell function and survival. 
  • Circulating Mucosal-Associated Invariant T Cells in a Large Cohort of Healthy Chinese Individuals From Newborn to Elderly. 
  • Clinical and immunologic features of selective IgA deficiency. 
  • Clinical spectrum and prognosis of follicular lymphoma with blastoid transformation: case series and a review of the literature. 
  • Cloning of B cells from autoimmune MRL-lpr/lpr and MRL.xid mice. 
  • Cloning of mitogen- and antigen-reactive B lymphocytes on filter paper disks: phenotypic and genotypic analysis of B cell colonies. 
  • Collagen type-V is a danger signal associated with primary graft dysfunction in lung transplantation. 
  • Comparative analysis of antigen loading strategies of dendritic cells for tumor immunotherapy. 
  • Comparison of thymocyte development and cytokine production in CD7-deficient, CD28-deficient and CD7/CD28 double-deficient mice. 
  • Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2. 
  • Complement component C3d-antigen complexes can either augment or inhibit B lymphocyte activation and humoral immunity in mice depending on the degree of CD21/CD19 complex engagement. 
  • Complete DiGeorge syndrome: persistence of profound immunodeficiency. 
  • Con A-induced suppressor cell function depends on the activation of the CD4+CD45RA inducer T cell subpopulation. 
  • Conditional antibody expression to avoid central B cell deletion in humanized HIV-1 vaccine mouse models. 
  • Conditions for an in vitro culture of murine mixed hematopoietic colonies and their putative cellular origin. 
  • Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals. 
  • Containment of simian immunodeficiency virus infection in vaccinated macaques: correlation with the magnitude of virus-specific pre- and postchallenge CD4+ and CD8+ T cell responses. 
  • Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. 
  • Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination. 
  • Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors. 
  • Coordinated posttranscriptional mRNA population dynamics during T-cell activation. 
  • Copy number variation of KIR genes influences HIV-1 control. 
  • Correction of proliferative responses in purine nucleoside phosphorylase (PNP)-deficient T lymphocytes by retroviral-mediated PNP gene transfer and expression. 
  • Correlates of nontransmission in US women at high risk of human immunodeficiency virus type 1 infection through sexual exposure. 
  • Corrigendum to:Agent-based modeling of the context dependency in T cell recognition. 
  • Costimulation, coinhibition and cancer. 
  • Costimulator dependence of lymphokine secretion by naive and activated CD4+ T lymphocytes from TCR transgenic mice. 
  • Critical role of the tumor suppressor tuberous sclerosis complex 1 in dendritic cell activation of CD4 T cells by promoting MHC class II expression via IRF4 and CIITA. 
  • Cross-Reactivity to Kynureninase Tolerizes B Cells That Express the HIV-1 Broadly Neutralizing Antibody 2F5. 
  • Crosstalk Between T and B Cells in the Germinal Center After Transplantation. 
  • Cryopreserved Mesenchymal Stromal Cells Are Susceptible to T-Cell Mediated Apoptosis Which Is Partly Rescued by IFNγ Licensing. 
  • Culture kinetics of glycolytic enzyme induction, glucose utilization, and thymidine incorporation of extended-exposure phytohemagglutinin-stimulated human lymphocytes. 
  • Cutaneous T cell lymphoma. Lymphocyte phenotype analysis after anti-thymocyte globulin therapy. 
  • Cutting Edge: Localization of linker for activation of T cells to lipid rafts is not essential in T cell activation and development. 
  • Cutting edge: a role for the adaptor protein LAT in human NK cell-mediated cytotoxicity. 
  • Cutting edge: hierarchy of chemokine receptor and TCR signals regulating T cell migration and proliferation. 
  • Cyclosporine A inhibits Ca2+-dependent stimulation of the Na+/H+ antiport in human T cells. 
  • Cyclosporine inhibition of a murine B cell lymphoma. 
  • Cytochalasins enhance the proliferation of CD4 cells through the CD3-Ti antigen receptor complex or the CD2 molecule through an effect on early events of activation. 
  • Cytokine production induced by Mycobacterium tuberculosis lipoarabinomannan. Relationship to chemical structure. 
  • Cytokine profiles in seronegative volunteers immunized with a recombinant canarypox and gp120 prime-boost HIV-1 vaccine. NIAID AIDS Vaccine Evaluation Group. 
  • Cytotoxic T-lymphocyte-associated antigen-4. 
  • DNA and immunoglobulin synthesis by rabbit peripheral blood lymphocytes in vitro: complete and incomplete stimulation. 
  • DNA repair in human leukaemic lymphocytes. 
  • DNA vaccines expressing different forms of simian immunodeficiency virus antigens decrease viremia upon SIVmac251 challenge. 
  • Decreased expression levels of CD22 and L-selectin on peripheral blood B lymphocytes from patients with bullous pemphigoid. 
  • Decreased protein synthesis of transforming lymphocytes from aged humans: relationship to impaired mitogenesis with age. 
  • Defective mononuclear leukocyte chemotaxis: a previously unrecognized immune dysfunction. Studies in a patient with chronic mucocutaneous candidiasis. 
  • Defective signaling in a subpopulation of CD4(+) T cells in the absence of Ca(2+)/calmodulin-dependent protein kinase IV. 
  • Defective survival and activation of thymocytes in transgenic mice expressing a catalytically inactive form of Ca2+/calmodulin-dependent protein kinase IV. 
  • Deficiency of Mucosal-Associated Invariant T Cells in TCRJα18 Germline Knockout Mice. 
  • Degenerate TCR recognition and dual DR2 restriction of autoreactive T cells: implications for the initiation of the autoimmune response in multiple sclerosis. 
  • Delineation of the role of platelet-activating factor in the immunoglobulin G2 antibody response. 
  • Dendritic cell CD83: a therapeutic target or innocent bystander? 
  • Dendritic cell responses to early murine cytomegalovirus infection: subset functional specialization and differential regulation by interferon alpha/beta. 
  • Dendritic cell transmigration through brain microvessel endothelium is regulated by MIP-1alpha chemokine and matrix metalloproteinases. 
  • Dendritic cells improve the generation of Epstein-Barr virus-specific cytotoxic T lymphocytes for the treatment of posttransplantation lymphoma. 
  • Dendritic cells infected with a vaccinia vector carrying the human gp100 gene simultaneously present multiple specificities and elicit high-affinity T cells reactive to multiple epitopes and restricted by HLA-A2 and -A3. 
  • Dependence of germinal center B cells on expression of CD21/CD35 for survival. 
  • Depleting regulatory T cells with arginine-rich, cell-penetrating, peptide-conjugated morpholino oligomer targeting FOXP3 inhibits regulatory T-cell function. 
  • Depression of cell-mediated immunity in atopic eczema. 
  • Depression of lymphocyte transformation and exacerbation of Behcet's syndrome by ingestion of english walnuts. 
  • Detailed analysis of cytomegalovirus (CMV)-specific T cells expanded for adoptive immunotherapy of CMV infection following allogeneic stem cell transplantation for malignant disease. 
  • Determination of the functional status of alloreactive T cells by interferon-gamma kinetics. 
  • Development and distribution of a human B cell subpopulation identified by the HB-4 monoclonal antibody. 
  • Development of immunity in human severe primary T cell deficiency following haploidentical bone marrow stem cell transplantation. 
  • Diacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses. 
  • Dietary flavonoid naringenin induces regulatory T cells via an aryl hydrocarbon receptor mediated pathway. 
  • Differences in chromatin proteins of resting and growing human lymphocytes. 
  • Differences in intraepithelial lymphocyte T cell subsets isolated from murine small versus large intestine. 
  • Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals. 
  • Differential phosphorylation of functional tyrosines in CD19 modulates B-lymphocyte activation. 
  • Differential regulation of accessory mitogenic signaling receptors by the T cell antigen receptor. 
  • Differential requirement for the SAP-Fyn interaction during NK T cell development and function. 
  • Differential requirement of RasGRP1 for γδ T cell development and activation. 
  • Differentiation of human T lymphocytes. I. Acquisition of a novel human cell surface protein (p80) during normal intrathymic T cell maturation. 
  • Direct interaction between HLA-B and carbamazepine activates T cells in patients with Stevens-Johnson syndrome. 
  • Discontinuous expression of a membrane antigen (HB-7) during B lymphocyte differentiation. 
  • Disruption of diacylglycerol metabolism impairs the induction of T cell anergy. 
  • Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism. 
  • Distinct kinetics of Gag-specific CD4+ and CD8+ T cell responses during acute HIV-1 infection. 
  • Does thalidomide affect IL-2 response and production? 
  • Donor-reactive T-cell stimulation history and precursor frequency: barriers to tolerance induction. 
  • Down-regulation of the orphan nuclear receptor ROR gamma t is essential for T lymphocyte maturation. 
  • Dyshematopoiesis in combined immune deficiency with congenital neutropenia. 
  • E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression. 
  • EBV latent membrane protein 2A induces autoreactive B cell activation and TLR hypersensitivity. 
  • ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation. 
  • ERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulum. 
  • Early B-cell activation after West Nile virus infection requires alpha/beta interferon but not antigen receptor signaling. 
  • Early activation and cell cycle entry of resting B cells after Fab-anti-Ig treatment: role of receptor crosslinking. 
  • Early events in human T cell ontogeny. Phenotypic characterization and immunohistologic localization of T cell precursors in early human fetal tissues. 
  • Early-outgrowth of endothelial progenitor cells can function as antigen-presenting cells. 
  • Effect of B-cell depletion on viral replication and clinical outcome of simian immunodeficiency virus infection in a natural host. 
  • Effect of Depot Medoxyprogesterone Acetate on Immune Functions and Inflammatory Markers of HIV-Infected Women. 
  • Effect of anti-CD4 antibody treatment on inflammatory arthritis in MRL-lpr/lpr mice. 
  • Effect of anti-human immunodeficiency virus nucleoside analogs on mitochondrial DNA and its implication for delayed toxicity. 
  • Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virus. 
  • Effect of intraocular gamma-interferon on immunoregulatory properties of iris and ciliary body cells. 
  • Effect of protein depletion on serum factors for lymphocyte transformation. 
  • Effect of serum source on protein-free diet lymphocyte blastogenesis. 
  • Effect of thymectomy on human peripheral blood T cell pools in myasthenia gravis. 
  • Effect os xid on anti-DNA B-cell precursors. 
  • Effects of bacterial DNA on cytokine production by (NZB/NZW)F1 mice. 
  • Effects of cyclosporine in experimental cryptococcal meningitis. 
  • Effects of human immunodeficiency virus type 1 on CD4 lymphocyte subset activation. 
  • Effects of murine cytomegalovirus infection on the immune response to a tumor allograft. 
  • Effects of photoperiod history on immune responses to intermediate day lengths in Siberian hamsters (Phodopus sungorus). 
  • Effects of protein nutrition on lymphocyte transformation. 
  • Efficacy of DNA and fowlpox virus priming/boosting vaccines for simian/human immunodeficiency virus. 
  • Efficient Culture of Human Naive and Memory B Cells for Use as APCs. 
  • Electron transport complex I is required for CD8+ T cell function. 
  • Ena/VASP proteins regulate activated T-cell trafficking by promoting diapedesis during transendothelial migration. 
  • Endothelial antigen presentation: stimulation of previously activated but not naïve TCR-transgenic mouse T cells. 
  • Engagement of NKG2D on bystander memory CD8 T cells promotes increased immunopathology following Leishmania major infection. 
  • Engagement of the adhesion receptor CD22 triggers a potent stimulatory signal for B cells and blocking CD22/CD22L interactions impairs T-cell proliferation. 
  • Engineering B cells with mRNA. 
  • Engineering DNA vaccines via co-delivery of co-stimulatory molecule genes. 
  • Enhanced T cell responses due to diacylglycerol kinase zeta deficiency. 
  • Enhanced potency of plasmid DNA microparticle human immunodeficiency virus vaccines in rhesus macaques by using a priming-boosting regimen with recombinant proteins. 
  • Enumerating antigen-specific T-cell responses in peripheral blood: a comparison of peptide MHC Tetramer, ELISpot, and intracellular cytokine analysis. 
  • Enzyme replacement therapy with polyethylene glycol-adenosine deaminase in adenosine deaminase deficiency: overview and case reports of three patients, including two now receiving gene therapy. 
  • Epithelial-thymocyte interactions in human thymus. 
  • Epstein Barr virus binding induces internalization of the C3d receptor: a novel immunotoxin delivery system. 
  • Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation. 
  • Evaluation of CD86/CD28 and CD40/CD154 pathways in regulating monocyte-derived CD80 expression during their interaction with allogeneic endothelium. 
  • Ex vivo expansion, maturation, and activation of umbilical cord blood-derived T lymphocytes with IL-2, IL-12, anti-CD3, and IL-7. Potential for adoptive cellular immunotherapy post-umbilical cord blood transplantation. 
  • Ex vivo spermine dialdehyde treatment prevents lethal GVHD in a murine bone marrow transplantation model. 
  • Exfoliative cytopathologic studies in organ transplantation. V. The diagnosis of rejection in the immediate postoperative period. 
  • Expansion of tumor-T cell pairs from fine needle aspirates of melanoma metastases. 
  • Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor. 
  • Exploiting Pre-Existing CD4+ T Cell Help from Bacille Calmette-Guérin Vaccination to Improve Antiviral Antibody Responses. 
  • Expression of C3d receptors during human B cell differentiation: immunofluorescence analysis with the HB-5 monoclonal antibody. 
  • Expression of Mls determinants in mice exhibiting the severe combined immunodeficiency (scid) mutation or X-linked immunodeficiency (xid) defect. 
  • Expression of T-lymphoblast-encoded HLA-DR, MT, and SB antigens on human T-B lymphoblast hybrids. 
  • Expression of cytokine mRNA in murine splenic dendritic cells and better induction of T cell-derived cytokines by dendritic cells than by macrophages during in vitro costimulation assay using specific antigens. 
  • Expression of early activation antigen (CD69) during human thymic development. 
  • Expression of membrane Hsp90 is a molecular signature of T cell activation. 
  • Expression of multiple chemokine genes by a human mast cell leukemia. 
  • Expression of surface CD1d in the extravillous trophoblast cells of early gestational placenta is downregulated in a manner dependent on trophoblast differentiation. 
  • Expression of the human leukocyte adhesion molecule, LAM1. Identity with the TQ1 and Leu-8 differentiation antigens. 
  • Expression, distribution, and biochemistry of human CD39. Role in activation-associated homotypic adhesion of lymphocytes. 
  • Factors influencing survival in pediatric acute leukemia. The SWCCSG experience, 1958-1970. 
  • Fatal cytomegalovirus bronchiolitis in a patient with Nezelof's syndrome. 
  • Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans. 
  • Fetal regulatory T cells and peripheral immune tolerance in utero: implications for development and disease. 
  • Fibronectin is an immunosuppressive substance associated with epithelial ovarian cancer. 
  • Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes. 
  • Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse. 
  • FoxO-dependent regulation of diacylglycerol kinase α gene expression. 
  • Fragmentation of Escherichia coli type 1 fimbriae exposes cryptic D-mannose-binding sites. 
  • Function of the LFA-1 and T4 molecules in the direct activation of resting human B lymphocytes by T lymphocytes. 
  • Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif. 
  • Functional characteristics and survival requirements of memory CD4+ T lymphocytes in vivo. 
  • Functional coordination and HuR-mediated regulation of mRNA stability during T cell activation. 
  • Functional cure of SIVagm infection in rhesus macaques results in complete recovery of CD4+ T cells and is reverted by CD8+ cell depletion. 
  • Functional invariant NKT cells in pig lungs regulate the airway hyperreactivity: a potential animal model. 
  • Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. 
  • Functional, non-clonal IgMa-restricted B cell receptor interactions with the HIV-1 envelope gp41 membrane proximal external region. 
  • General immunocompetence of rats bearing avian sarcoma virus-induced intracranial tumors. 
  • Generalized microsporum audoninii infection and depressed cellular immunity associated with a missing plasma factor required for lymphocyte blastogenesis. 
  • Generation of human autologous melanoma-specific cytotoxic T-cells using HLA-A2-matched allogeneic melanomas. 
  • Generation of melanoma-specific, cytotoxic CD4(+) T helper 2 cells: requirement of both HLA-DR15 and Fas antigens on melanomas for their lysis by Th2 cells. 
  • Generation of normal lymphocyte populations following transplantation of adenosine-deaminase-deficient fetal liver cells. 
  • Genetic and structural analyses of affinity maturation in the humoral response to HIV-1. 
  • Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4+ T cells. 
  • Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch Recombination. 
  • Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival. 
  • Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways. 
  • Glucose-regulated protein 94/glycoprotein 96 elicits bystander activation of CD4+ T cell Th1 cytokine production in vivo. 
  • Graft-versus-host disease: the viewpoint from the donor T cell. 
  • HIV-1 GP120-mediated immune suppression and lymphocyte destruction in the absence of viral infection. 
  • HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life. 
  • HIV-1 infection of human T lymphocytes results in enhanced alpha 5 beta 1 integrin expression. 
  • HIV-1-negative female sex workers sustain high cervical IFNɛ, low immune activation, and low expression of HIV-1-required host genes. 
  • HIV-1-specific CD4+ T lymphocyte turnover and activation increase upon viral rebound. 
  • HIV-1MN recombinant glycoprotein 160 vaccine-induced cellular and humoral immunity boosted by HIV-1MN recombinant glycoprotein 120 vaccine. National Institute of Allergy and Infectious Diseases AIDS Vaccine Evaluation Group. 
  • HIV-DNA priming alters T cell responses to HIV-adenovirus vaccine even when responses to DNA are undetectable. 
  • HL A typing, mixed leukocyte reactivity, and skin graft survival in a family with a recombinant at the HL-1 chromosomal region (major transplantation region). 
  • HLA class II molecules on monocytes regulate T cell proliferation through physical interaction in the CD3 activation pathway. 
  • HLA class II molecules transduce accessory signals affecting the CD3 but not the interleukin-2 activation pathway in T blasts. 
  • HSV oncolytic therapy upregulates interferon-inducible chemokines and recruits immune effector cells in ovarian cancer. 
  • Harnessing the effect of adoptively transferred tumor-reactive T cells on endogenous (host-derived) antitumor immunity. 
  • Helper Th1 and Th2 cell responses following mucosal or systemic immunization with cholera toxin. 
  • Hematopoietic stem cell transplantation for severe combined immunodeficiency in the neonatal period leads to superior thymic output and improved survival. 
  • Heparan sulfate is a plasma biomarker of acute cellular allograft rejection. 
  • Herpesvirus saimiri transformation of HIV type 1 suppressive CD8+ lymphocytes from an HIV type 1-infected asymptomatic individual. 
  • Heterologous immunity triggered by a single, latent virus in Mus musculus: combined costimulation- and adhesion- blockade decrease rejection. 
  • High CTLA-4 expression on Th17 cells results in increased sensitivity to CTLA-4 coinhibition and resistance to belatacept. 
  • High levels of B-cell activating factor in patients with active chronic graft-versus-host disease. 
  • Human IgE synthesis in vitro: a reassessment. 
  • Human T cells specifically activated against autologous malignant melanoma. 
  • Human T lymphocyte antigens as defined by monoclonal antibodies. 
  • Human antigen-specific memory T cells express the homing receptor (LAM-1) necessary for lymphocyte recirculation. 
  • Human cytotoxic T cells specific for autologous melanoma cells: successful generation from lymph node cells in seven consecutive cases. 
  • Human dendritic cells transfected with RNA encoding prostate-specific antigen stimulate prostate-specific CTL responses in vitro. 
  • Human equivalent of the mouse Nude/SCID phenotype: long-term evaluation of immunologic reconstitution after bone marrow transplantation. 
  • Human intrathymic T cell differentiation. 
  • Human lymphocyte antigens: production of a monoclonal antibody that defines functional thymus-derived lymphocyte subsets. 
  • Human lymphocyte complement receptors. Stimulation of lymphocyte RNA synthesis by complement-coated human red cells. 
  • Human lymphocyte differentiation antigens HB-10 and HB-11. II. Differential production of B cell growth and differentiation factors by distinct helper T cell subpopulations. 
  • Human lymphocyte proliferation responses following primary immunization with rabies vaccine as neoantigen. 
  • Human malignant and mitogen-transformed cells contain retroviral P15E-related antigen. 
  • Human monocytes as intermediaries between allogeneic endothelial cells and allospecific T cells: a role for direct scavenger receptor-mediated endothelial membrane uptake in the initiation of alloimmunity. 
  • Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells. 
  • Human postnatal CD4- CD8- CD3- thymic T cell precursors differentiate in vitro into T cell receptor delta-bearing cells. 
  • Human regulatory T cells kill tumor cells through granzyme-dependent cytotoxicity upon retargeting with a bispecific antibody. 
  • Human retrovirus-related synthetic peptides inhibit T lymphocyte proliferation. 
  • Human thymic epithelial cells function as accessory cells for autologous mature thymocyte activation. 
  • Human thymic epithelial cells produce interleukin 1. 
  • Humoral autoimmunity to basement membrane antigens is regulated in C57BL/6 and MRL/MpJ mice transgenic for anti-laminin Ig receptors. 
  • Humoral immune responses in L-selectin-deficient mice. 
  • Hyper IgM syndrome associated with defective CD40-mediated B cell activation. 
  • Hypercholesterolemia Increases Colorectal Cancer Incidence by Reducing Production of NKT and γδ T Cells from Hematopoietic Stem Cells. 
  • Hypervariable region 1 variant acting as TCR antagonist affects hepatitis C virus-specific CD4+ T cell repertoire by favoring CD95-mediated apoptosis. 
  • ICAM-1 (CD54) expression on B lymphocytes is associated with their costimulatory function and can be increased by coactivation with IL-1 and IL-7. 
  • IFN-gamma dictates allograft fate via opposing effects on the graft and on recipient CD8 T cell responses. 
  • IFN-gamma production in response to neuropathogenic Cas-Br-M murine leukemia virus infection. 
  • IFN-α inhibits telomerase in human CD8⁺ T cells by both hTERT downregulation and induction of p38 MAPK signaling. 
  • IL-12-Dependent Cytomegalovirus-Specific CD4+ T Cell Proliferation, T-bet Induction, and Effector Multifunction during Primary Infection Are Key Determinants for Early Immune Control. 
  • IL-1β-dependent activation of dendritic epidermal T cells in contact hypersensitivity. 
  • IL-2, IL-4, and IFN-gamma gene expression versus secretion in superantigen-activated T cells. Distinct requirement for costimulatory signals through adhesion molecules. 
  • IL-2-dependent adaptive control of NK cell homeostasis. 
  • IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells. 
  • IL-2-induced CD4+ T-cell expansion in HIV-infected patients is associated with long-term decreases in T-cell proliferation. 
  • IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection. 
  • IL-7 enhancement of antigen-driven activation/expansion of HIV-1-specific cytotoxic T lymphocyte precursors (CTLp). 
  • IL-7 enhances the survival and maintains the size of naive T cells. 
  • IL-7 expands lymphocyte populations and enhances immune responses to sipuleucel-T in patients with metastatic castration-resistant prostate cancer (mCRPC). 
  • IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival. 
  • IL15 Agonists Overcome the Immunosuppressive Effects of MEK Inhibitors. 
  • Ia+ T cells in new onset Graves' disease. 
  • Identification of a B cell signature associated with renal transplant tolerance in humans. 
  • Identification of a new transmembrane adaptor protein that constitutively binds Grb2 in B cells. 
  • Identification of alpha-melanocyte stimulating hormone as a potential immunosuppressive factor in aqueous humor. 
  • Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor. 
  • Ig-positive lymphocytes in Hodgkin's disease. 
  • IgG-Immune Complexes Promote B Cell Memory by Inducing BAFF. 
  • Immune Reconstitution but Persistent Activation After 48 Weeks of Antiretroviral Therapy in Youth With Pre-Therapy CD4 >350 in ATN 061. 
  • Immune checkpoint modulation enhances HIV-1 antibody induction. 
  • Immune function during intravenous administration of a soybean oil emulsion. 
  • Immune reconstitution in children after unrelated cord blood transplantation. 
  • Immune responses in asymptomatic HIV-1-infected patients after HIV-DNA immunization followed by highly active antiretroviral treatment. 
  • Immune responses of breast cancer patients to mutated epidermal growth factor receptor (EGF-RvIII, Delta EGF-R, and de2-7 EGF-R). 
  • Immune responses of human lymphocytes in vitro. 
  • Immune responses to human immunodeficiency virus (HIV) type 1 induced by canarypox expressing HIV-1MN gp120, HIV-1SF2 recombinant gp120, or both vaccines in seronegative adults. NIAID AIDS Vaccine Evaluation Group. 
  • Immune signatures of murine and human cancers reveal unique mechanisms of tumor escape and new targets for cancer immunotherapy. 
  • Immune status assay (ISA): a noninvasive procedure for studying allograft rejection. 
  • Immune-inflammation gene signatures in endometriosis patients. 
  • Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques. 
  • Immunologic basis for allopurinol-induced severe cutaneous adverse reactions: HLA-B*58:01-restricted activation of drug-specific T cells and molecular interaction. 
  • Immunologic chimerism as evidence of bone marrow graft acceptance in an identical twin with acute lymphocytic leukemia. 
  • Immunologic profile of human immunodeficiency virus-infected patients during viral remission and relapse on antiretroviral therapy. 
  • Immunologic studies before and after splenectomy in a patient with the Wiskott-Aldrich syndrome. 
  • Immunologic studies on T and B lymphocytes in chimpanzees: effects of thymectomy and irradiation. 
  • Immunologic targeting of FOXP3 in inflammatory breast cancer cells. 
  • Immunological mechanisms of periodontal tissue destruction. 
  • Immunological properties of bacterial DNA. 
  • Immunomodulation of experimental autoimmune encephalomyelitis by helminth ova immunization. 
  • Immunoreactive vasoactive intestinal peptide contributes to the immunosuppressive activity of normal aqueous humor. 
  • Immunostimulatory properties of genomic DNA from different bacterial species. 
  • Immunosurveillance by antiangiogenesis: tumor growth arrest by T cell-derived thrombospondin-1. 
  • Impact of vaccine type on HIV-1 vaccine elicited antibody durability and B cell gene signature. 
  • Impaired function of CD4+/CD25+ T regulatory lymphocytes characterizes the self-limited hepatitis A virus infection. 
  • Impaired immune responses and B-cell proliferation in mice lacking the Id3 gene. 
  • Impaired lymphocyte transformation in Hodgkin's disease. Evidence for depletion of circulating t-lymphocytes. 
  • Improving Mycobacterium bovis bacillus Calmette-Guèrin as a vaccine delivery vector for viral antigens by incorporation of glycolipid activators of NKT cells. 
  • In Vitro Differentiation of CD4+ T Cell Effector and Regulatory Subsets. 
  • In vitro analysis of the human antiporcine T-cell repertoire. 
  • In vivo and in vitro effects of acute graft-versus-host serum in the rat. 
  • In-vivo impaired T helper 1 cell development in submandibular lymph nodes due to IL-12 deficiency following antigen injection into the anterior chamber of the eye. 
  • Inability of gestational hormones to account for the inhibitory effects of pregnancy plasmas on lymphocyte responses in vitro. 
  • Increased BCR responsiveness in B cells from patients with chronic GVHD. 
  • Increased Protein Degradation Improves Influenza Virus Nucleoprotein-Specific CD8+ T Cell Activation In Vitro but Not in C57BL/6 Mice. 
  • Increased inflammation but similar physical composition and function in older-aged, HIV-1 infected subjects. 
  • Increased production of IL-4 by gut T-cell lines from patients with dermatitis herpetiformis compared to patients with isolated gluten-sensitive enteropathy. 
  • Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma. 
  • Induction of CD56 and TCR-independent activation of T cells with aging. 
  • Induction of HIV-1 broad neutralizing antibodies in 2F5 knock-in mice: selection against membrane proximal external region-associated autoreactivity limits T-dependent responses. 
  • Induction of autologous mixed lymphocyte culture responses by myelin basic protein-reactive T cell clones. 
  • Induction of immune activation by a novel immunomodulatory oligonucleotide without thymocyte apoptosis. 
  • Induction of immune responses by schistosome granuloma macrophages. 
  • Induction of immune responses with anti-idiotypic antibodies: implications for the induction of protective immunity. 
  • Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. 
  • Induction of polyclonal prostate cancer-specific CTL using dendritic cells transfected with amplified tumor RNA. 
  • Induction of primary, antiviral cytotoxic, and proliferative responses with antigens administered via dendritic cells. 
  • Induction of primary, human antigen-specific cytotoxic T lymphocytes in vitro using dendritic cells pulsed with peptides. 
  • Infection with Mycobacterium bovis BCG diverts traffic of myelin oligodendroglial glycoprotein autoantigen-specific T cells away from the central nervous system and ameliorates experimental autoimmune encephalomyelitis. 
  • Inhibition by anti-HLA class II monoclonal antibodies of monoclonal antibody OKT3-induced T cell proliferation. Studies at the mRNA level. 
  • Inhibition of Human Dendritic Cell ER Stress Response Reduces T Cell Alloreactivity Yet Spares Donor Anti-tumor Immunity. 
  • Inhibition of T cell costimulation by VCAM-1 prevents murine graft-versus-host disease across minor histocompatibility barriers. 
  • Inhibition of in vitro anti-DNA B-cell responses by cyclosporine. 
  • Inhibition of invariant chain expression in dendritic cells presenting endogenous antigens stimulates CD4+ T-cell responses and tumor immunity. 
  • Inhibition of lymphocyte proliferation by a synthetic peptide homologous to envelope proteins of human and animal retroviruses. 
  • Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins. 
  • Initial B-cell responses to transmitted human immunodeficiency virus type 1: virion-binding immunoglobulin M (IgM) and IgG antibodies followed by plasma anti-gp41 antibodies with ineffective control of initial viremia. 
  • Initiation of antiretroviral therapy during primary HIV-1 infection induces rapid stabilization of the T-cell receptor beta chain repertoire and reduces the level of T-cell oligoclonality. 
  • Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression. 
  • Interaction of macrophages and lymphocytes for lymphokine production and cellular proliferation. 
  • Interaction of pokeweed mitogen with monocytes in the activation of human lymphocytes. 
  • Interferon-regulated chemokine score associated with improvement in disease activity in refractory myositis patients treated with rituximab. 
  • Interleukin 2 produced by activated B lymphocytes acts as an autocrine proliferation-inducing lymphokine. 
  • Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism. 
  • Interleukin-15-Stimulated Natural Killer Cells Clear HIV-1-Infected Cells following Latency Reversal Ex Vivo. 
  • Interleukin-2 reverses CD8(+) T cell exhaustion in clinical malignant pleural effusion of lung cancer. 
  • Interleukin-3 expression by activated T cells involves an inducible, T-cell-specific factor and an octamer binding protein. 
  • Intracellular BH3 Profiling Reveals Shifts in Antiapoptotic Dependency in Human B Cell Maturation and Mitogen-Stimulated Proliferation. 
  • Intracellular adhesion molecule-1 modulates beta-chemokines and directly costimulates T cells in vivo. 
  • Intranasal immunization is superior to vaginal, gastric, or rectal immunization for the induction of systemic and mucosal anti-HIV antibody responses. 
  • Involvement of an ATP-dependent peptide chaperone in cross-presentation after DNA immunization. 
  • Involvement of linker for activation of T cells in the costimulatory signaling pathways. 
  • Involvement of multiple factors in the clonal deletion of self-reactive T cells. 
  • Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22. 
  • Irgm1 regulates metabolism and function in T cell subsets. 
  • Isolation and generation of human dendritic cells. 
  • It never rains but it pours: potential role of butyrophilins in inhibiting anti-tumor immune responses. 
  • JunB Controls Intestinal Effector Programs in Regulatory T Cells. 
  • K12/SECTM1, an interferon-γ regulated molecule, synergizes with CD28 to costimulate human T cell proliferation. 
  • Kinetics of TCR use in response to repeated epitope-specific immunization. 
  • Kinetics of immunoglobulin synthesis and secretion by resting and pokeweed mitogen-transformed human lymphocytes. 
  • Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development. 
  • L-selectin is involved in lymphocyte migration to sites of inflammation in the skin: delayed rejection of allografts in L-selectin-deficient mice. 
  • L-selectin is not required for T cell-mediated autoimmune diabetes. 
  • L-selectin shedding does not regulate constitutive T cell trafficking but controls the migration pathways of antigen-activated T lymphocytes. 
  • LAB: a new membrane-associated adaptor molecule in B cell activation. 
  • LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. 
  • LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. 
  • Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals. 
  • Lack of generation of killer cells in the mixed lymphocyte reaction between mitogen-stimulated and unstimulated autologous lymphocytes. 
  • Lack of viral escape and defective in vivo activation of human immunodeficiency virus type 1-specific cytotoxic T lymphocytes in rapidly progressive infection. 
  • Leprosy in a mangabey monkey--naturally acquired infection. 
  • Leptin metabolically licenses T cells for activation to link nutrition and immunity. 
  • Lessons from a multisite international trial in the Caribbean and South America of an HIV-1 Canarypox vaccine (ALVAC-HIV vCP1452) with or without boosting with MN rgp120. 
  • Letal, A tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells. 
  • Leukocyte composition of human breast cancer. 
  • Leukocyte entry into sites of inflammation requires overlapping interactions between the L-selectin and ICAM-1 pathways. 
  • Leukocyte phenotypic changes in an in vitro model of ABO hemolytic transfusion reaction. 
  • Leukotriene C4 induces migration of human monocyte-derived dendritic cells without loss of immunostimulatory function. 
  • Levels of Foxp3 in regulatory T cells reflect their functional status in transplantation. 
  • Ligand-specific selection of MHC class II-restricted thymocytes in fetal thymic organ culture. 
  • Ligation of MHC class I and class II molecules can lead to heterologous desensitization of signal transduction pathways that regulate homotypic adhesion in human lymphocytes. 
  • Limited ability of humoral immune responses in control of viremia during infection with SIVsmmD215 strain. 
  • Lin^- CCR2⁺ hematopoietic stem and progenitor cells overcome resistance to PD-1 blockade. 
  • Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding. 
  • Linking immune responses with fibrosis in allergic eye disease. 
  • Lipopolysaccharide and phorbol esters induce differentiation but have opposite effects on phosphatidylinositol turnover and Ca2+ mobilization in 70Z/3 pre-B lymphocytes. 
  • Long-term efficacy of enzyme replacement therapy for adenosine deaminase (ADA)-deficient severe combined immunodeficiency (SCID). 
  • Longitudinal assessment of immune response and viral characteristics in HIV-infected patients with prolonged CD4(+)/viral load discordance. 
  • Longitudinal peripheral blood lymphocyte subsets correlate with decreased disease activity in juvenile dermatomyositis. 
  • Loss of DNAM-1 contributes to CD8+ T-cell exhaustion in chronic HIV-1 infection. 
  • Loss of tolerance of anti-dsDNA B cells in mice overexpressing CD19. 
  • Loss of tumorigenicity following in vitro MuLV infection is associated with induction of peritoneal natural killer cell activity. 
  • Low incidence of acute rejection in hepatitis B virus positive liver transplant recipients and the impact of hepatitis B immunoglobulin. 
  • Lung effector memory and activated CD4+ T cells display enhanced proliferation in surfactant protein A-deficient mice during allergen-mediated inflammation. 
  • Lymphocyte activation gene-3-associated protein networks are associated with HDL-cholesterol and mortality in the Trans-omics for Precision Medicine program. 
  • Lymphocyte activation markers may predict the presence of donor specific alloreactivity in pediatric living related liver transplant recipients. 
  • Lymphocyte activation, cell-mediated cytotoxicity and their relationship to dietary fat-enhanced mammary tumorigenesis in C3H/OUJ mice. 
  • Lymphocyte responses to purified ragweed allergens in vitro. I. Proliferative responses in normal, newborn, agammaglobulinemic, and atopic subjects. 
  • Lymphocyte responses to ragweed antigens from different sources. 
  • Lymphocyte subpopulations and responsiveness in rats bearing intracranial tumors induced by avian sarcoma virus. 
  • Lymphocytic Choriomeningitis Virus Expands a Population of NKG2D+CD8+ T Cells That Exacerbates Disease in Mice Coinfected with Leishmania major. 
  • Lymphocytic leukemia in children: prognostic significance of clinical and laboratory findings at time of diagnosis. 
  • Lymphoma models for B cell activation and tolerance. V. Anti-Ig mediated growth inhibition is reversed by phorbol myristate acetate but does not involve changes in cytosolic free calcium. 
  • Lymphopenic immunologic deficiency in identical twins: lymphocyte allografting and graft-versus-host disease following treatment with albumin-gradient-separated paternal bone marrow cells. 
  • MAGE-1-specific precursor cytotoxic T-lymphocytes present among tumor-infiltrating lymphocytes from a patient with breast cancer: characterization and antigen-specific activation. 
  • MHC class I-presented tumor antigens identified in ovarian cancer by immunoproteomic analysis are targets for T-cell responses against breast and ovarian cancer. 
  • MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function. 
  • MYC/BCL2 protein coexpression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures: a report from The International DLBCL Rituximab-CHOP Consortium Program. 
  • Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction. 
  • Matched and mismatched metabolic fuels in lymphocyte function. 
  • Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. 
  • Maximizing the retention of antigen specific lymphocyte function after cryopreservation. 
  • MeCP2 enforces Foxp3 expression to promote regulatory T cells' resilience to inflammation. 
  • Measurement of an adhesion molecule as an indicator of inflammatory disease activity. Up-regulation of the receptor for hyaluronate (CD44) in rheumatoid arthritis. 
  • Measurement of the DNA synthetic capacity of activated lymphocytes: nucleotide triphosphate incorporation by permeabilized cells. 
  • Mechanism of Epstein-Barr virus-induced human B-lymphocyte activation. 
  • Mechanisms of corticosteroid action on lymphocyte subpopulations. IV. Effects of in vitro hydrocortisone on naturally occuring and mitogen-induced suppressor cells in man. 
  • Mechanisms of corticosteroid action on lymphocyte subpopulations. V. Effects of in vivo hydrocortisone on the circulatory kinetics and function of naturally occuring and mitogen-induced suppressor cells in man. 
  • Mechanisms of immune stimulation by bacterial DNA. 
  • Mechanisms of immune-related adverse events during the treatment of cancer with immune checkpoint inhibitors. 
  • Mechanisms of polyclonal B-cell activation in autoimmune B6-lpr/lpr mice. 
  • Mechanisms of self-tolerance and autoimmunity: from whole-animal phenotypes to molecular pathways. 
  • Mechanisms of tolerance induced by PG490-88 in a bone marrow transplantation model. 
  • Melanoma-specific cytotoxic T cells generated from peripheral blood lymphocytes. Implications of a renewable source of precursors for adoptive cellular immunotherapy. 
  • Melatonin enhancement of splenocyte proliferation is attenuated by luzindole, a melatonin receptor antagonist. 
  • Membrane receptors and in vitro responsiveness of lymphocytes in human immunodeficiency. 
  • Memory of Inflammation in Regulatory T Cells. 
  • Metabolic Barriers to T Cell Function in Tumors. 
  • Metabolic pathways in T cell fate and function. 
  • Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. 
  • Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability and resistance to metabolic inhibition in CD8 versus CD4 T cells. 
  • Metastatic colorectal cancer cells from patients previously treated with chemotherapy are sensitive to T-cell killing mediated by CEA/CD3-bispecific T-cell-engaging BiTE antibody. 
  • Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia. 
  • Mice immunosuppressed by murine retrovirus infection (MAIDS) are susceptible to cytomegalovirus retinitis. 
  • Mice lacking expression of the chemokines CCL21-ser and CCL19 (plt mice) demonstrate delayed but enhanced T cell immune responses. 
  • Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis. 
  • Minding the gap: The impact of B-cell tolerance on the microbial antibody repertoire. 
  • Minimal requirement of tyrosine residues of linker for activation of T cells in TCR signaling and thymocyte development. 
  • Minors come of age: Minor histocompatibility antigens and graft-versus-host disease. 
  • Mitogen-induced B-cell proliferation activates Chk2-dependent G1/S cell cycle arrest. 
  • Mitogenic stimulation of human B lymphocytes by the mannose-specific adhesin on Escherichia coli type 1 fimbriae. 
  • Mnk1 and 2 are dispensable for T cell development and activation but important for the pathogenesis of experimental autoimmune encephalomyelitis. 
  • Modeling the impact of Trichomonas vaginalis infection on HIV transmission in HIV-infected individuals in medical care. 
  • Modified MHC restriction of donor-origin T cells in humans with severe combined immunodeficiency transplanted with haploidentical bone marrow stem cells. 
  • Modified T-cell receptor ligands: moving beyond a strict occupancy model for T-cell activation by antigen. 
  • Modified responses to recipient and donor B cells by genetically donor T cells from human haploidentical bone marrow chimeras. 
  • Modulation of CD45 tyrosine phosphatase activity by antigen. 
  • Modulation of lymphocyte functions by group A streptococcal membrane. 
  • Modulation of the intracellular Ca2+ and inositol trisphosphate concentrations in murine T lymphocytes by the glycosylphosphatidylinositol-anchored protein sgp-60. 
  • Molecular basis of T cell inactivation by CTLA-4. 
  • Molecular dissection of lymphocyte signal transduction pathways. 
  • Molecular impact of selective NFKB1 and NFKB2 signaling on DLBCL phenotype. 
  • Molecular signals in B cell activation. I. Differential refractory effects of incomplete signaling by ionomycin or PMA relate to autocrine IL-2 production and IL-2R expression. 
  • Molecular signals in B cell activation. II. IL-2-mediated signals are required in late G1 for transition to S phase after ionomycin and PMA treatment. 
  • Monitoring cellular immune responses to cancer immunotherapy. 
  • Monoclonal Antibodies, Derived from Humans Vaccinated with the RV144 HIV Vaccine Containing the HVEM Binding Domain of Herpes Simplex Virus (HSV) Glycoprotein D, Neutralize HSV Infection, Mediate Antibody-Dependent Cellular Cytotoxicity, and Protect Mice from Ocular Challenge with HSV-1. 
  • Monoclonal antibodies to CD2 and lymphocyte function-associated antigen 3 inhibit human thymic epithelial cell-dependent mature thymocyte activation. 
  • Monoclonal antibody OKT3-induced T cell proliferation: differential role of HLA class II determinants expressed by T cells and monocytes. 
  • Monoclonal immunoglobulin-secreting lymphoma in a patient with severe combined immunodeficiency disease. 
  • Monocyte chemoattractant protein-1 is sufficient for the chemotaxis of monocytes and lymphocytes in transgenic mice but requires an additional stimulus for inflammatory activation. 
  • Monocyte chemotactic mechanisms in patients with hypernephroma. 
  • Monocytes prime autoreactive T cells after myocardial infarction. 
  • Mononuclear cells from patients with the hyper-IgE syndrome produce little IgE when they are stimulated with recombinant human interleukin-4. 
  • Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys. 
  • Mouse CD20 expression and function. 
  • Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4. 
  • Mucosal and systemic immune activation is present in human immunodeficiency virus-exposed seronegative women. 
  • Mucosal co-infections and HIV-1 transmission and pathogenesis. 
  • Mucosal immunity to HIV-1: systemic and vaginal antibody responses after intranasal immunization with the HIV-1 C4/V3 peptide T1SP10 MN(A). 
  • Mucosal-associated invariant T cell responses differ by sex in COVID-19. 
  • Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice. 
  • Multivalent cross-linking of membrane Ig sensitizes murine B cells to a broader spectrum of CpG-containing oligodeoxynucleotide motifs, including their methylated counterparts, for stimulation of proliferation and Ig secretion. 
  • Murine cytomegalovirus infection: hematological, morphological, and functional study of lymphoid cells. 
  • NK and LAK susceptibility varies inversely with target cell MHC class I antigen expression in a rat epithelial tumour system. 
  • NK cell activation by dendritic cell vaccine: a mechanism of action for clinical activity. 
  • NKG2D-mediated activation of cytotoxic lymphocytes: unique signaling pathways and distinct functional outcomes. 
  • NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease. 
  • Naive human T cells are activated and proliferate in response to the heme oxygenase-1 inhibitor tin mesoporphyrin. 
  • Natural IgM Switches the Function of Lipopolysaccharide-Activated Murine Bone Marrow-Derived Dendritic Cells to a Regulatory Dendritic Cell That Suppresses Innate Inflammation. 
  • Natural killer cell mobilization and egress following acute exercise in men with prostate cancer. 
  • Natural killing target antigens as inducers of interferon: studies with an immunoselected, natural killing-resistant human T lymphoblastoid cell line. 
  • Negative regulation of T cell activation and autoimmunity by the transmembrane adaptor protein LAB. 
  • Negative regulation of TCR signaling by linker for activation of X cells via phosphotyrosine-dependent and -independent mechanisms. 
  • Negative regulation of lymphocyte activation by the adaptor protein LAX. 
  • Negative regulation of mTOR activation by diacylglycerol kinases. 
  • Neonatal Rhesus Macaques Have Distinct Immune Cell Transcriptional Profiles following HIV Envelope Immunization. 
  • Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells. 
  • New perspectives on zoledronic acid in breast cancer: potential augmentation of anticancer immune response. 
  • Nicotinamide adenine dinucleotide (NAD) and its metabolites inhibit T lymphocyte proliferation: role of cell surface NAD glycohydrolase and pyrophosphatase activities. 
  • Notch 1 signaling regulates peripheral T cell activation. 
  • Nucleic acid scavenging polymers inhibit extracellular DNA-mediated innate immune activation without inhibiting anti-viral responses. 
  • Nutritional effects on T-cell immunometabolism. 
  • OX40+ Regulatory T Cells in Cutaneous Squamous Cell Carcinoma Suppress Effector T-Cell Responses and Associate with Metastatic Potential. 
  • Ocular molecules and cells that regulate immune responses in situ. 
  • On the stimulating capacity of human leukemic REH cells in a mixed lymphocyte culture. 
  • Oncolytic virus-derived type I interferon restricts CAR T cell therapy. 
  • Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1. 
  • Optimization of the sequence of antigen loading and CD40-ligand-induced maturation of dendritic cells. 
  • Ovarian carcinoma expresses the NKG2D ligand Letal and promotes the survival and expansion of CD28- antitumor T cells. 
  • PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation. 
  • PD-1 and PD-L1 expression in cardiac transplantation. 
  • PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis. 
  • PILAR is a novel modulator of human T-cell expansion. 
  • PP6 controls T cell development and homeostasis by negatively regulating distal TCR signaling. 
  • Packed red blood cells suppress T-cell proliferation through a process involving cell-cell contact. 
  • Pairing of VH gene families with the lambda 1 light chain: evidence for a non-stochastic association. 
  • Pentoxifylline and other methyl xanthines inhibit interleukin-2 receptor expression in human lymphocytes. 
  • Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells. 
  • Permanent survival of fully MHC-mismatched islet allografts by targeting a single chemokine receptor pathway. 
  • Persistence of zinc-binding bacterial superantigens at the surface of antigen-presenting cells contributes to the extreme potency of these superantigens as T-cell activators. 
  • Phenotypic and functional characterization of cytotoxic T lymphocytes by flow cytometry. 
  • Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes. 
  • Phenytoin hypersensitivity. 
  • Phospholipase D in TCR-Mediated Signaling and T Cell Activation. 
  • Photocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be 'preferentially' transported to the cSMAC. 
  • Photoinactivation of lymphohemopoietic cells: studies in transfusion medicine and bone marrow transplantation. 
  • Plexin-D1 is a novel regulator of germinal centers and humoral immune responses. 
  • Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection. 
  • Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway. 
  • Polysaccharides PS-G and protein LZ-8 from Reishi (Ganoderma lucidum) exhibit diverse functions in regulating murine macrophages and T lymphocytes. 
  • Polyvalent human immunodeficiency virus synthetic immunogen comprised of envelope gp120 T helper cell sites and B cell neutralization epitopes. 
  • Porcine CD80: cloning, characterization, and evidence for its role in direct human T-cell activation. 
  • Positive and negative elements regulate human interleukin 3 expression. 
  • Potentiation of CD3-induced expression of the linker for activation of T cells (LAT) by the calcineurin inhibitors cyclosporin A and FK506. 
  • Pre-T cell receptor's clashing signals: "should I stay or should I go". 
  • Prednisone-responsive aplastic anemia associated with T-lymphocyte proliferation. 
  • Preexisting infection with human T-cell lymphotropic virus type 2 neither exacerbates nor attenuates simian immunodeficiency virus SIVmac251 infection in macaques. 
  • Preexposure of resting B cells to interferon-gamma enhances their proliferative response to subsequent activation signals. 
  • Premature cell senescence and T cell receptor-independent activation of CD8+ T cells in juvenile idiopathic arthritis. 
  • Preparation and characterization of lymphocyte-activating factor (LAF) from acute monocytic and myelomonocytic leukemia cells. 
  • Pretransplant Desensitization with Costimulation Blockade and Proteasome Inhibitor Reduces DSA and Delays Antibody-Mediated Rejection in Highly Sensitized Nonhuman Primate Kidney Transplant Recipients. 
  • Primary vascularization of the graft determines the immunodominance of murine minor H antigens during organ transplantation. 
  • Prime-boost regimens with adjuvanted synthetic long peptides elicit T cells and antibodies to conserved regions of HIV-1 in macaques. 
  • Priming and activation of human ovarian and breast cancer-specific CD8+ T cells by polyvalent Listeria monocytogenes-based vaccines. 
  • Priming for virus-specific CD8+ but not CD4+ cytotoxic T lymphocytes with synthetic lipopeptide is influenced by acylation units and liposome encapsulation. 
  • Programming the magnitude and persistence of antibody responses with innate immunity. 
  • Proinflammatory cytokine expression profile in degenerated and herniated human intervertebral disc tissues. 
  • Proline isomerases at the crossroads of protein folding, signal transduction, and immunosuppression. 
  • Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal. 
  • Properties of mouse leukemia viruses. XIX. Effective antibody therapy of AKR leukemia occurs independently of virus neutralization and produces long-term changes in the virus status of the thymus. 
  • Prospects for cellular immunotherapy for metastatic melanoma. 
  • Prostaglandin E2-mediated regulation of immunoglobulin G2 via interferon gamma. 
  • Protease activity of normal and PHA stimulated human lymphocytes. 
  • Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress response. 
  • Prurigo Nodularis Is Characterized by Systemic and Cutaneous T Helper 22 Immune Polarization. 
  • Purified lymphocyte function-associated antigen-3 (LFA-3) activates human thymocytes via the CD2 pathway. 
  • QS-21 promotes an adjuvant effect allowing for reduced antigen dose during HIV-1 envelope subunit immunization in humans. 
  • Quantitating therapeutically relevant T-cell responses to cancer vaccines. 
  • Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production. 
  • Quiescent phenotype of tumor-specific CD8+ T cells following immunization. 
  • RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation. 
  • RNA-Based Vaccines in Cancer Immunotherapy. 
  • RNA-Modified T Cells Mediate Effective Delivery of Immunomodulatory Cytokines to Brain Tumors. 
  • Rapamycin antagonizes cyclosporin A- and tacrolimus (FK506)-mediated augmentation of linker for activation of T cell expression in T cells. 
  • Re-engineered CD40 receptor enables potent pharmacological activation of dendritic-cell cancer vaccines in vivo. 
  • Receptors for prostaglandin E(2) that regulate cellular immune responses in the mouse. 
  • Recognition and killing of autologous, primary glioblastoma tumor cells by human cytomegalovirus pp65-specific cytotoxic T cells. 
  • Recombinant human interleukin 1 alpha: purification and biological characterization. 
  • Recombinant hydrophilic region of murine retroviral protein p15E inhibits stimulated T-lymphocyte proliferation. 
  • Reconstitution of a T cell receptor-stimulated plasma membrane calcium transporter: lack of dependence on inositol phosphates. 
  • Recovery of B-cell homeostasis after rituximab in chronic graft-versus-host disease. 
  • Redistribution of protein kinase C activity in human monocytes: correlation with activation of the respiratory burst. 
  • Reduced GRK2 level in T cells potentiates chemotaxis and signaling in response to CCL4. 
  • Reduced expression levels of nucleotide excision repair genes in lung cancer: a case-control analysis. 
  • Redundancy renders the glycoprotein 96 receptor scavenger receptor A dispensable for cross priming in vivo. 
  • Regulation and properties of the rat Ca2+/calmodulin-dependent protein kinase IV gene and its protein products. 
  • Regulation of B lymphocyte development and activation by the CD19/CD21/CD81/Leu 13 complex requires the cytoplasmic domain of CD19. 
  • Regulation of RasGRP1 function in T cell development and activation by its unique tail domain. 
  • Regulation of T cell proliferation by JMJD6 and PDGF-BB during chronic hepatitis B infection. 
  • Regulation of T-helper-cell lineage development by osteopontin: the inside story. 
  • Regulation of basement membrane-reactive B cells in BXSB, (NZBxNZW)F1, NZB, and MRL/lpr lupus mice. 
  • Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions. 
  • Regulation of leukocyte migration by activation of the leukocyte adhesion molecule-1 (LAM-1) selectin. 
  • Regulation of lymphocyte development and activation by the LAT family of adapter proteins. 
  • Regulation of nuclear Prointerleukin-16 and p27(Kip1) in primary human T lymphocytes. 
  • Regulation of the B cell response to T-dependent antigens by classical pathway complement. 
  • Regulation of the human interleukin-3 gene. 
  • Regulation of the immune response. I. Regulatory cell equilibrium in the "virgin" state. 
  • Regulation of the immune response. II. Concomitant idiotope-specific enhancement and suppression can result in a phenotypically normal response. 
  • Regulation of the tyrosine kinase-dependent adhesion pathway in human lymphocytes through CD45. 
  • Regulatory B cells as inhibitors of immune responses and inflammation. 
  • Regulatory T cells decrease invariant natural killer T cell-mediated pregnancy loss in mice. 
  • Renal Effects of Cytokines in Hypertension. 
  • Renal allograft-infiltrating lymphocytes. A prospective analysis of in vitro growth characteristics and clinical relevance. 
  • Renal effects of cytokines in hypertension. 
  • Renal transplantation between HL-A haploidentical donor-recipient pairs: functional and morphological evaluation. 
  • Renal transplantation between HL-A identical donor-recipient pairs. Functional and morphological evaluation. 
  • Replicating rather than nonreplicating adenovirus-human immunodeficiency virus recombinant vaccines are better at eliciting potent cellular immunity and priming high-titer antibodies. 
  • Replication of type I herpes simplex virus in primary cultures of hairy cell leukemic leukocytes. 
  • Replication-defective canarypox (ALVAC) vectors effectively activate anti-human immunodeficiency virus-1 cytotoxic T lymphocytes present in infected patients: implications for antigen-specific immunotherapy. 
  • Requirement for Abl kinases in T cell receptor signaling. 
  • Requirement of MIP-1 alpha for an inflammatory response to viral infection. 
  • Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells. 
  • Resistance to human immunodeficiency virus type 1 in vitro as a surrogate of vaccine-induced protective immunity. 
  • Results of an ELISPOT proficiency panel conducted in 11 laboratories participating in international human immunodeficiency virus type 1 vaccine trials. 
  • Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells. 
  • Role of CCR7 in facilitating direct allosensitization and regulatory T-cell function in high-risk corneal transplantation. 
  • Role of JAK3 in CD40-mediated signaling. 
  • Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. 
  • Role of T-cell activation in salt-sensitive hypertension. 
  • Role of Toll-like receptors in HMGB1 release from macrophages. 
  • Role of calcium in T-lymphocyte activation. 
  • SAP-mediated inhibition of diacylglycerol kinase α regulates TCR-induced diacylglycerol signaling. 
  • SATB1 Expression Governs Epigenetic Repression of PD-1 in Tumor-Reactive T Cells. 
  • Safety and immunogenicity of a CTL multiepitope peptide vaccine for HIV with or without GM-CSF in a phase I trial. 
  • Safety and immunogenicity of a live recombinant canarypox virus expressing HIV type 1 gp120 MN MN tm/gag/protease LAI (ALVAC-HIV, vCP205) followed by a p24E-V3 MN synthetic peptide (CLTB-36) administered in healthy volunteers at low risk for HIV infection. AGIS Group and L'Agence Nationale de Recherches sur Le Sida. 
  • Safety and immunogenicity of an HIV-1 recombinant canarypox vaccine in newborns and infants of HIV-1-infected women. 
  • Secondary allergic T cell responses are regulated by dendritic cell-derived thrombospondin-1 in the setting of allergic eye disease. 
  • Selection of TCR V alpha by MHC class II predicts superantigen reactivity. 
  • Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB. 
  • Selective costimulation modulation with abatacept: a look at quality-of-life outcomes in patients with rheumatoid arthritis. 
  • Selective modification of antigen-specific T cells by RNA electroporation. 
  • Semaphorin 6D regulates the late phase of CD4+ T cell primary immune responses. 
  • Semaphorin 7A modulates cytokine-induced memory-like responses by human natural killer cells. 
  • Serial measurement of serum interleukin-2 receptor levels in patients with rheumatoid arthritis: limited evidence for a role of T cell activation in clinical exacerbations. 
  • Serum elevation of B lymphocyte stimulator does not increase regulatory B cells in glioblastoma patients undergoing immunotherapy. 
  • Severe aplastic anemia associated with chronic mucocutaneous candidiasis. Immunologic and hematologic reconstitution after allogeneic bone marrow transplantation. 
  • Severe combined immunodeficiency with natural killer-cell predominance: abrogation of graft-versus-host disease and immunologic reconstitution with HLA-identical bone marrow cells. 
  • Sexually transmitted infections and immune activation among HIV-infected but virally suppressed youth on antiretroviral therapy. 
  • Signaling via LAT (linker for T-cell activation) and Syk/ZAP70 is required for ERK activation and NFAT transcriptional activation following CD2 stimulation. 
  • Simian-human immunodeficiency virus SHIV89.6-induced protection against intravaginal challenge with pathogenic SIVmac239 is independent of the route of immunization and is associated with a combination of cytotoxic T-lymphocyte and alpha interferon responses. 
  • Similar CD19 dysregulation in two autoantibody-associated autoimmune diseases suggests a shared mechanism of B-cell tolerance loss. 
  • Similarities in long-term alloreactive T cell lines propagated from transfusion-enhanced and control-rejecting rat renal allografts. 
  • Simvastatin inhibits secretion of Th17-polarizing cytokines and antigen presentation by DCs in patients with relapsing remitting multiple sclerosis. 
  • Single-cell analysis by mass cytometry reveals metabolic states of early-activated CD8+ T cells during the primary immune response. 
  • Sites of B-cell activation in vivo. 
  • Skewed VH and V kappa gene family expression and pairing occurs among B lymphocytes in autoimmune motheaten mice. 
  • Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination. 
  • Soluble B7-H1: differences in production between dendritic cells and T cells. 
  • Soluble CD14, CD163, and CD27 biomarkers distinguish ART-suppressed youth living with HIV from healthy controls. 
  • Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist. 
  • Specific activation strategies for amplification of low CTL signals. 
  • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. 
  • Stability and function of regulatory T cells expressing the transcription factor T-bet. 
  • Stability of Th1 and Th2 populations. 
  • Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replication. 
  • Status of activation of circulating vaccine-elicited CD8+ T cells. 
  • Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells. 
  • Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA. 
  • Stimulation of in vitro proliferation of murine lymphocytes by synthetic oligodeoxynucleotides. 
  • Stimulation of murine lymphocyte proliferation by a phosphorothioate oligonucleotide with antisense activity for herpes simplex virus. 
  • Stochastic pairing of heavy-chain and kappa light-chain variable gene families occurs in polyclonally activated B cells. 
  • Studies of human bone marrow treated with soybean lectin and sheep erythrocytes: stepwise analysis of cell morphology, phenotype and function. 
  • Studies on the mechanism and specificity of the effect of the synthetic random copolymer GLAT on graft-versus-host disease. 
  • Substance P and calcitonin gene-related peptide increase IL-1 beta, IL-6 and TNF alpha secretion from human peripheral blood mononuclear cells. 
  • Superfibronectin, a multimeric form of fibronectin, increases HIV infection of primary CD4+ T lymphocytes. 
  • Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia. 
  • Suppression of an antibody to adenosine-deaminase (ADA) in an ADA-deficient patient receiving polyethylene glycol modified adenosine deaminase. 
  • Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity. 
  • Suppressive effect on polyclonal B-cell activation of a synthetic peptide homologous to a transmembrane component of oncogenic retroviruses. 
  • Surfactant protein A integrates activation signal strength to differentially modulate T cell proliferation. 
  • Surfactant protein A modulates induction of regulatory T cells via TGF-β. 
  • Sweet nothings: sensing of sugar metabolites controls T cell function. 
  • Syn-capping of human T lymphocyte adhesion/activation molecules and their redistribution during interaction with endothelial cells. 
  • Synergy between tumor immunotherapy and antiangiogenic therapy. 
  • Synovial microenvironment-T cell interactions. Human T cells bind to fibroblast-like synovial cells in vitro. 
  • Synthetic peptide in mineral oil adjuvant elicits simian immunodeficiency virus-specific CD8+ cytotoxic T lymphocytes in rhesus monkeys. 
  • Synthetic peptides containing T and B cell epitopes from human immunodeficiency virus envelope gp120 induce anti-HIV proliferative responses and high titers of neutralizing antibodies in rhesus monkeys. 
  • T Cell Responses against Mycobacterial Lipids and Proteins Are Poorly Correlated in South African Adolescents. 
  • T cell activation deficiency associated with an aberrant pattern of protein tyrosine phosphorylation after CD3 perturbation in Down's syndrome. 
  • T cell activation up-regulates the expression of the focal adhesion kinase Pyk2: opposing roles for the activation of protein kinase C and the increase in intracellular Ca2+. 
  • T cell activation within different intraocular compartments during experimental uveitis. 
  • T cell receptor binding kinetics and special role of Valpha in T cell development and activation. 
  • T cell receptor-dependent activation of human lymphocytes through cell surface ganglioside GT1b: implications for innate immunity. 
  • T cell stemness and dysfunction in tumors are triggered by a common mechanism. 
  • T cell traffic and the inflammatory response in experimental autoimmune uveoretinitis. 
  • T cell-mediated elimination of B7.2 transgenic B cells. 
  • T cells as a self-referential, sensory organ. 
  • T lymphocyte depletion of human peripheral blood and bone marrow using monoclonal antibodies and magnetic microspheres. 
  • T lymphocyte ontogeny in adenosine deaminase-deficient severe combined immune deficiency after treatment with polyethylene glycol-modified adenosine deaminase. 
  • T lymphocytes from chronic HCV-infected patients are primed for activation-induced apoptosis and express unique pro-apoptotic gene signature. 
  • T-Cell recovery in adults and children following umbilical cord blood transplantation. 
  • T-bet-dependent expression of osteopontin contributes to T cell polarization. 
  • T-cell-receptor affinity and thymocyte positive selection. 
  • TCR alpha-CD3 delta epsilon association is the initial step in alpha beta dimer formation in murine T cells and is limiting in immature CD4+ CD8+ thymocytes. 
  • TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation. 
  • TGF-beta inhibits the in vitro induction of lymphokine-activated killing activity. 
  • TGF-beta-induced myelin peptide-specific regulatory T cells mediate antigen-specific suppression of induction of experimental autoimmune encephalomyelitis. 
  • TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation. 
  • Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease. 
  • Tenofovir Has Minimal Effect on Biomarkers of Bone Health in Youth with HIV Receiving Initial Antiretroviral Therapy. 
  • Tgf-beta inhibits activation and uveitogenicity of primary but not of fully polarized retinal antigen-specific memory-effector T cells. 
  • Th1-Polarized, Dengue Virus-Activated Human Mast Cells Induce Endothelial Transcriptional Activation and Permeability. 
  • The B cell surface molecule B1 is functionally linked with B cell activation and differentiation. 
  • The B-cell repertoire for autoantibodies: frequency of precursor cells for anti-DNA antibodies. 
  • The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen. 
  • The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules. 
  • The CD28 signaling pathway regulates glucose metabolism. 
  • The First B-Cell Tolerance Checkpoint in Mice and Humans: Control by AID. 
  • The IFN pregnancy recognition hormone IFN-tau blocks both development and superantigen reactivation of experimental allergic encephalomyelitis without associated toxicity. 
  • The Importance of IL-6 in the Development of LAT-Mediated Autoimmunity. 
  • The Mycobacterium tuberculosis 71-kDa heat-shock protein induces proliferation and cytokine secretion by murine gut intraepithelial lymphocytes. 
  • The PD-1 Regulatory Axis Inhibits T Cell-Independent B Cell Memory Generation and Reactivation. 
  • The allo- and viral-specific immunosuppressive effect of belatacept, but not tacrolimus, attenuates with progressive T cell maturation. 
  • The aminopeptidase ERAAP shapes the peptide repertoire displayed by major histocompatibility complex class I molecules. 
  • The anti-apoptotic Bcl-2 family member Mcl-1 promotes T lymphocyte survival at multiple stages. 
  • The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytes. 
  • The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19. 
  • The chemokine CX3CL1 regulates NK cell activity in vivo. 
  • The chemotactic attraction of human fibroblasts to a lymphocyte-derived factor. 
  • The clinical application of monoclonal antibody therapies in renal transplantation. 
  • The effect of age on the accumulation of labile triosephosphate isomerase and thymidine incorporation in pokeweed mitogen stimulated human lymphocytes. 
  • The effects of a 10% soybean oil emulsion on lymphocyte transformation. 
  • The effects of aging on phosphofructokinase induction during lymphocyte mitogenesis in relation to DNA and protein synthesis. 
  • The effects of leukemosuppressive immunotherapy on thymic infectious cell centers in AKR mice. 
  • The effects of nonsteroidal antiinflammatory drug therapy in early rheumatoid arthritis on serum levels of soluble interleukin 2 receptor, CD4, and CD8. 
  • The essential role of L-glutamine in lymphocyte differentiation in vitro. 
  • The expression of plasma nucleosomes in mice undergoing in vivo apoptosis. 
  • The future of organ and tissue transplantation: can T-cell costimulatory pathway modifiers revolutionize the prevention of graft rejection? 
  • The future of rheumatoid arthritis treatment. 
  • The germinal center: a crucible for lymphocyte selection. 
  • The human antiporcine cellular repertoire. In vitro studies of acquired and innate cellular responsiveness. 
  • The immune response to staphylococcal nuclease: a probe of cellular and humoral antigen-specific receptors. 
  • The immunogenetics of the major histocompatibility chromosomal region in man. 
  • The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model. 
  • The importance of LAT in the activation, homeostasis, and regulatory function of T cells. 
  • The importance of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kilodaltons sterile-alpha motif domain in thymic selection and T-cell activation. 
  • The influence of DNA structure on the in vitro stimulation of murine lymphocytes by natural and synthetic polynucleotide antigens. 
  • The influence of base sequence on the immunological properties of defined oligonucleotides. 
  • The influence of base sequence on the immunostimulatory properties of DNA. 
  • The influence of the lpr gene on B cell activation: differential antibody expression in lpr congenic mouse strains. 
  • The inhibitory coreceptor CD22 restores B cell signaling by developmentally regulating Cd45-/- immunodeficient B cells. 
  • The interleukin-2 receptor α chain (CD25) plays an important role in regulating monocyte-derived CD40 expression during anti-porcine cellular responses. 
  • The kinetics of immunoglobulin synthesis by pokeweed mitogen stimulated peripheral blood lymphocytes in multiple myeloma. 
  • The linker for activation of B cells (LAB)/non-T cell activation linker (NTAL) regulates triggering receptor expressed on myeloid cells (TREM)-2 signaling and macrophage inflammatory responses independently of the linker for activation of T cells. 
  • The liver kinase B1 is a central regulator of T cell development, activation, and metabolism. 
  • The long isoform of cellular FLIP is essential for T lymphocyte proliferation through an NF-kappaB-independent pathway. 
  • The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity. 
  • The nephritogenic immune response. 
  • The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus. 
  • The potential of human allogeneic juvenile chondrocytes for restoration of articular cartilage. 
  • The requirement of linker for activation of T cells in the primary and memory responses of CD8 T cells. 
  • The requirement of reversible cysteine sulfenic acid formation for T cell activation and function. 
  • The requirements for CTL-mediated rejection of cancer in humans: NKG2D and its role in the immune responsiveness of melanoma. 
  • The road to tolerance: renal transplant tolerance induction in nonhuman primate studies and clinical trials. 
  • The role and regulation of mTOR in T-lymphocyte function. 
  • The role of CD4-Lck in T-cell receptor antagonism: evidence for negative signaling. 
  • The role of cell surface receptors in the activation of human B cells by phosphorothioate oligonucleotides. 
  • The role of membrane-associated adaptors in T cell receptor signalling. 
  • The role of receptors for complement in the induction of polyclonal B-cell proliferation and differentiation. 
  • The role of surface ig binding in the activation of human B cells by phosphorothioate oligodeoxynucleotides. 
  • The role of the L3T4 molecule in mitogen and antigen-activated signal transduction. 
  • The role of the LAT-PLC-gamma1 interaction in T regulatory cell function. 
  • The role of the thymic microenvironment in promotion of early stages of human T cell maturation. 
  • The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse. 
  • Three populations of cells with dendritic morphology exist in peripheral blood, only one of which is infectable with human immunodeficiency virus type 1. 
  • Thrombospondin-1 derived from APCs regulates their capacity for allosensitization. 
  • Thromboxane augmentation of alloreactive T cell function. 
  • Thymic function, aging, and AIDS. 
  • Thymic microenvironment reconstitution after postnatal human thymus transplantation. 
  • Thymic output markers indicate immune dysfunction in DiGeorge syndrome. 
  • Thymocyte LFA-1 and thymic epithelial cell ICAM-1 molecules mediate binding of activated human thymocytes to thymic epithelial cells. 
  • Thymus transplantation in complete DiGeorge syndrome: immunologic and safety evaluations in 12 patients. 
  • Tissue plasminogen activator (tPA) signal sequence enhances immunogenicity of MVA-based vaccine against tuberculosis. 
  • Tolerance induced by apoptotic antigen-coupled leukocytes is induced by PD-L1+ and IL-10-producing splenic macrophages and maintained by T regulatory cells. 
  • Topoisomerase II levels during granulocytic maturation in vitro and in vivo. 
  • Toxocara antigen and mitogen-induced lymphocyte blastogenesis for diagnosis of visceral larva migrans: clinical and experimental findings in macaques and human beings. 
  • Transcription factor NF-kappaB regulates inducible CD83 gene expression in activated T lymphocytes. 
  • Transcriptional regulator Id2 is required for the CD4 T cell immune response in the development of experimental autoimmune encephalomyelitis. 
  • Transduction of human melanoma cells with the gamma interferon gene enhances cellular immunity. 
  • Transfection of RNA encoding tumor antigens following maturation of dendritic cells leads to prolonged presentation of antigen and the generation of high-affinity tumor-reactive cytotoxic T lymphocytes. 
  • Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes. 
  • Transforming growth factor β-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression. 
  • Transmission of HIV by antigen presenting cells during T-cell activation: prevention by 3'-azido-3'-deoxythymidine. 
  • Transplantation of thymus tissue in complete DiGeorge syndrome. 
  • Treatment of rheumatoid arthritis with a DR4/1 peptide. 
  • Treatment with immunotoxin. 
  • Tumor membrane lymphocyte stimulation assay in patients with renal cell carcinoma. 
  • Tumor necrosis factor, natural killer activity and other measures of immune function and inflammation in elderly men with heart failure. 
  • Tumor suppressor TSC1 is critical for T-cell anergy. 
  • Tumor-specific recognition of human myeloma cells by idiotype-induced CD8(+) T cells. 
  • Tumors as elusive targets of T-cell-based active immunotherapy. 
  • Unexpected positive control of NFκB and miR-155 by DGKα and ζ ensures effector and memory CD8+ T cell differentiation. 
  • Unexpected role of clathrin adaptor AP-1 in MHC-dependent positive selection of T cells. 
  • V(D)J recombinase activity in a subset of germinal center B lymphocytes. 
  • VH gene analysis of spontaneously activated B cells in adult MRL-lpr/lpr mice. J558 bias is not limited to classic lupus autoantibodies. 
  • Vaccination of vaccinia-naive adults with human immunodeficiency virus type 1 gp160 recombinant vaccinia virus in a blinded, controlled, randomized clinical trial. The AIDS Vaccine Clinical Trials Network. 
  • Vaccination with the immediate-early protein ICP47 of herpes simplex virus-type 1 (HSV-1) induces virus-specific lymphoproliferation, but fails to protect against lethal challenge. 
  • Vaccine-induced ICOS+CD38+ circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways. 
  • Vaccinia and cowpox viruses encode a novel secreted interleukin-1-binding protein. 
  • Variation in DNA and RNA synthetic responses during activation of lymphocytes from inbred strains of mice. 
  • Viral and bacterial infections induce expression of multiple NK cell receptors in responding CD8(+) T cells. 
  • Xenoreactivity of fetal and neonatal baboon intracellular antibody against the pig. 
  • ZAP-70 tyrosine kinase is required for the up-regulation of Fas ligand in activation-induced T cell apoptosis. 
  • Zinc and immunocompetence in elderly people: effects of zinc supplementation for 3 months. 
  • [Antitumoral action of interferons and interleukins in combination with radiotherapy. Part I: immunologic basis]. 
  • iPABP, an inducible poly(A)-binding protein detected in activated human T cells. 
  • mTOR and its tight regulation for iNKT cell development and effector function. 
  • mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis. 
  • mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation. 
  • polyethylene glycol-conjugated adenosine deaminase (ADA) therapy provides temporary immune reconstitution to a child with delayed-onset ADA deficiency. 
  • α4β7 Integrin is essential for contact hypersensitivity by regulating migration of T cells to skin. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Buckley, Rebecca Hatcher, James Buren Sidbury Distinguished Professor Emeritus of Pediatrics, in the School of Medicine, Pediatrics, Allergy and Immunology
  • Chen, Jun, Professor of Medicine, Duke Cancer Institute
  • Cianciolo, George James, Associate Professor Emeritus of Pathology, Pathology
  • Ciofani, Maria, Associate Professor of Integrative Immunobiology, Cell Biology
  • Ferrari, Guido, Professor in Surgery, Molecular Genetics and Microbiology
  • Hanks, Brent A., Associate Professor of Medicine, Pharmacology & Cancer Biology
  • Kelsoe, Garnett H., James B. Duke Distinguished Professor of Immunology, Integrative Immunobiology
  • Knechtle, Stuart Johnston, William R. Kenan, Jr. Distinguished Professor, Medicine, Nephrology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology
  • Lagoo, Anand Shreeram, Professor of Pathology, Pathology
  • Lee, Walter T, Professor of Head and Neck Surgery & Communication Sciences, Radiation Oncology
  • Luftig, Micah Alan, Professor of Molecular Genetics and Microbiology, Cell Biology
  • Pang, Herbert, Adjunct Assistant Professor in the Department of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
  • Pastva, Amy Martha, Professor in Orthopaedic Surgery, Cell Biology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering
  • Schanberg, Laura Eve, Professor of Pediatrics, Pediatrics, Rheumatology
  • Shinohara, Mari L., Professor of Integrative Immunobiology, Cell Biology
  • Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology
  • Sunday, Mary Elizabeth Anne, Professor of Pathology, Cell Biology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Integrative Immunobiology
  • Zennadi, Rahima, Associate Professor in Medicine, Pathology
  • Zhong, Xiaoping, Professor of Pediatrics, Integrative Immunobiology