Lysine

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  Subject Areas on Research

  • A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation. 
  • A Lamina-Associated Domain Border Governs Nuclear Lamina Interactions, Transcription, and Recombination of the Tcrb Locus. 
  • A Prob(e)able Route to Lysine Acylation. 
  • A chemical method for labeling lysine methyltransferase substrates. 
  • A fine line between molecular umbrella transport and ionophoric activity. 
  • A high resolution structure of an inhibitor complex of the extracellular nuclease of Staphylococcus aureus. I. Experimental procedures and chain tracing. 
  • A noncanonical function of sortase enables site-specific conjugation of small molecules to lysine residues in proteins. 
  • A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation. 
  • ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia. 
  • AcK-knowledge reversible acetylation. 
  • Acetylation goes global: the emergence of acetylation biology. 
  • Activation of human plasminogen by urokinase. Partial characterization of a pre-activation peptide. 
  • Active glycation in neurofibrillary pathology of Alzheimer disease: N(epsilon)-(carboxymethyl) lysine and hexitol-lysine. 
  • Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117. 
  • Amino acid uptake by isolated renal brush border membrane vesicles in various buffers. 
  • An examination of adaptive reversion in Saccharomyces cerevisiae. 
  • An inner activation gate controls TMEM16F phospholipid scrambling. 
  • An on-line archive of reconstructed hippocampal neurons. 
  • Anatomy of disturbed sleep in pallido-ponto-nigral degeneration. 
  • Association of calmodulin and smooth muscle myosin light chain kinase: application of a label selection technique with trace acetylated calmodulin. 
  • Association of increased spontaneous mutation rates with high levels of transcription in yeast. 
  • BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers. 
  • Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages. 
  • Chaperone-mediated 26S proteasome remodeling facilitates free K63 ubiquitin chain production and aggresome clearance. 
  • Characteristics of cystine uptake by cultured LLC-PK1 cells. 
  • Characteristics of lysine transport by isolated rat renal cortical tubule fragments. 
  • Characteristics of lysine uptake by isolated renal cortical tubule fragments from mature and immature dogs. 
  • Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. 
  • Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation. 
  • Cloning and sequencing of V genes from anti-osteosarcoma monoclonal antibodies TP-1 and TP-3: location of lysine residues and implications for radiolabeling. 
  • Course and laminar origin of the tectoparabigeminal pathway. 
  • Cystine and lysine transport in cultured human renal epithelial cells. 
  • Cystine-glutamate transport interactions in rat renal cortical tubules, brushborder vesicles, and cultured renal tubule cells. 
  • Decreased expression of lysyl hydroxylase 2 (LH2) in skin fibroblasts from three Ehlers-Danlos patients does not result from mutations in either the coding or proximal promoter region of the LH2 gene. 
  • Delta-like 1-Lysine613 regulates notch signaling. 
  • Desensitization and Incomplete Recovery of Hepatic Target Genes After Chronic Thyroid Hormone Treatment and Withdrawal in Male Adult Mice. 
  • Design, expression, and immunogenicity of a soluble HIV trimeric envelope fragment adopting a prefusion gp41 configuration. 
  • Development of magnetic resonance imaging contrast material for in vivo mapping of tissue transglutaminase activity. 
  • Developmental pattern of cystine transport in isolated rat renal tubules. 
  • Dipeptidyl peptidase IV (DPP IV/CD26) is a cell-surface plasminogen receptor. 
  • Directed evolution of a new catalytic site in 2-keto-3-deoxy-6-phosphogluconate aldolase from Escherichia coli. 
  • Disinhibition in rat superior colliculus mediated by GABAc receptors. 
  • Disruption of Acetyl-Lysine Turnover in Muscle Mitochondria Promotes Insulin Resistance and Redox Stress without Overt Respiratory Dysfunction. 
  • Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver. 
  • Domain structure and DNA binding regions of beta protein from bacteriophage lambda. 
  • Effect of FSH on protein biosynthesis in testes of the immature rat. 
  • Effect of lysine and threonine deficient and supplement rice diets on lipids of hepatic smooth and rough endoplasmic reticulum of rats. 
  • Effect of tissue transglutaminase on the solubility of proteins containing expanded polyglutamine repeats. 
  • Efficient sporulation of yeast in media buffered near pH6. 
  • Evidence for separate pathways within the tecto-geniculate projection in the tree shrew. 
  • Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure. 
  • Fibrinolysis and fibrinogenolysis by Val442-plasmin. 
  • Free pentosidine and neopterin as markers of progression rate in diabetic nephropathy. Collaborative Study Group. 
  • Functional asymmetry of transmembrane segments in nicotinic acetylcholine receptors. 
  • Gene A of X174. 1. Isolation and identification of its products. 
  • Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns. 
  • Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci. 
  • Hemoglobin Rahere, a human hemoglobin variant with amino acid substitution at the 2,3-diphosphoglycerate binding site. Functional consequences of the alteration and effects of bezafibrate on the oxygen bindings. 
  • Hemoglobin providence. Functional consequences of two alterations of the 2,3-diphosphoglycerate binding site at position beta 82. 
  • Hepatic mitochondrial membrane lipid environment and protein nutrition. 
  • Hepatic phosphatidylcholine synthesis in deficiency of lysine and threonine: effect of malathion. 
  • Heterogeneous basis of the type VIB form of Ehlers-Danlos syndrome (EDS VIB) that is unrelated to decreased collagen lysyl hydroxylation. 
  • High-level misincorporation of lysine for arginine at AGA codons in a fusion protein expressed in Escherichia coli. 
  • Hippocampal mossy fiber sprouting and synapse formation after status epilepticus in rats: visualization after retrograde transport of biocytin. 
  • Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. 
  • Histone Lactylation: A New Role for Glucose Metabolism. 
  • Histone deacetylase 6 (HDAC6) promotes the pro-survival activity of 14-3-3ζ via deacetylation of lysines within the 14-3-3ζ binding pocket. 
  • Homocystine uptake in isolated rat renal cortical tubules. 
  • Hydrolysis by somatic angiotensin-I converting enzyme of basic dipeptides from a cholecystokinin/gastrin and a LH-RH peptide extended at the C-terminus with gly-Arg/Lys-arg, but not from diarginyl insulin. 
  • Identification of a key lysine residue in heat shock protein 90 required for azole and echinocandin resistance in Aspergillus fumigatus. 
  • Identification of deacetylase substrates with the biotin switch approach. 
  • Identification of epsilon-N-trimethyllysine in a rat testis calcium-dependent regulatory protein of cyclic nucleotide phosphodiesterase. 
  • Interlaminar connections of the superior colliculus in the tree shrew. I. The superficial gray layer. 
  • Interlaminar connections of the superior colliculus in the tree shrew. II: Projections from the superficial gray to the optic layer. 
  • Interlaminar connections of the superior colliculus in the tree shrew. III: The optic layer. 
  • Intragenic regulation of the synthesis of phi chi 174 gene A proteins. 
  • Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH. 
  • K63 polyubiquitination is a new modulator of the oxidative stress response. 
  • Kinetic analysis of the zinc-dependent deacetylase in the lipid A biosynthetic pathway. 
  • Kinetic role of helix caps in protein folding is context-dependent. 
  • Laminar origin of ipsilateral tectopontine pathways. 
  • Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila. 
  • Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds. 
  • Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers. 
  • Lysine auxotrophy combined with deletion of the SecA2 gene results in a safe and highly immunogenic candidate live attenuated vaccine for tuberculosis. 
  • Lysine glutarylation is a protein posttranslational modification regulated by SIRT5. 
  • Lysine hydroxylation of collagen in a fibroblast cell culture system. 
  • Lysine modifications and autophagy. 
  • Lysine restricted diet for pyridoxine-dependent epilepsy: first evidence and future trials. 
  • Lysine(164)alpha of protein farnesyltransferase is important for both CaaX substrate binding and catalysis. 
  • MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. 
  • Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. 
  • Mass spectrometry- and lysine amidination-based protocol for thermodynamic analysis of protein folding and ligand binding interactions. 
  • Measuring acetyl-CoA and acetylated histone turnover in vivo: Effect of a high fat diet. 
  • Megalin mediates renal uptake of heavy metal metallothionein complexes. 
  • Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation. 
  • Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width. 
  • Methylation of histone H4 lysine 20 by PR-Set7 ensures the integrity of late replicating sequence domains in Drosophila. 
  • Mixed function oxidases in response to quality and quantity of dietary protein. 
  • Modification of fibrinogen by homocysteine thiolactone increases resistance to fibrinolysis: a potential mechanism of the thrombotic tendency in hyperhomocysteinemia. 
  • Modulation of tissue repair by regeneration enhancer elements. 
  • Molecular abnormalities of human plasminogen isolated from synovial fluid of rheumatoid arthritis patients. 
  • Morphometric and electrical properties of reconstructed hippocampal CA3 neurons recorded in vivo. 
  • Motility-indole-lysine medium for presumptive identification of enteric pathogens of Enterobacteriaceae. 
  • Motility-indole-lysine-sulfide medium. 
  • Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. 
  • Myelin basic protein stimulates plasminogen activation via tissue plasminogen activator following binding to independent l-lysine-containing domains. 
  • NMDA receptor antagonists disinhibit rat posterior cingulate and retrosplenial cortices: a potential mechanism of neurotoxicity. 
  • NMR structure note: solution structure of the core domain of MESD that is essential for proper folding of LRP5/6. 
  • Nitric oxide-generating polymers reduce platelet adhesion and smooth muscle cell proliferation. 
  • Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases. 
  • Nonspecific interstitial pneumonia, alveolar proteinosis, and abnormal proprotein trafficking resulting from a spontaneous mutation in the surfactant protein C gene. 
  • Novel chimeric spermidine synthase-saccharopine dehydrogenase gene (SPE3-LYS9) in the human pathogen Cryptococcus neoformans. 
  • Optical Control of CRISPR/Cas9 Gene Editing. 
  • Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the proliferation of muscle precursor cells by an epigenetic mechanism. 
  • Polyubiquitin Chains Linked by Lysine Residue 48 (K48) Selectively Target Oxidized Proteins In Vivo. 
  • Progressive mitochondrial protein lysine acetylation and heart failure in a model of Friedreich's ataxia cardiomyopathy. 
  • Protein biosynthesis in the testis. 3. Dual effect of glucose. 
  • Protein biosynthesis in the testis. I. Comparison between stimulation by FSH and glucose. 
  • Protein biosynthesis in the testis. II. Role of adenosine triphosphate (ATP) in stimulation by glucose. 
  • Protein imperfections: separating intrinsic from extrinsic variation of torsion angles. 
  • Proteinase binding and inhibition by the monomeric alpha-macroglobulin rat alpha 1-inhibitor-3. 
  • Proteome-wide analysis reveals widespread lysine acetylation of major protein complexes in the malaria parasite. 
  • Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation. 
  • Proteomic identification and functional characterization of MYH9, Hsc70, and DNAJA1 as novel substrates of HDAC6 deacetylase activity. 
  • Purification and some properties of the Glu- and Lys-human plasmin heavy chains. 
  • Quantitative and morphological analysis of dentate granule cells with recurrent basal dendrites from normal and epileptic rats. 
  • RNA editing generates tissue-specific sodium channels with distinct gating properties. 
  • Rapid cross-linking of elastin-like polypeptides with (hydroxymethyl)phosphines in aqueous solution. 
  • Rates of induction of specific translatable messenger RNAs for ovalbumin and avidin by steroid hormones. 
  • Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes. 
  • Recessive Rare Variants in Deoxyhypusine Synthase, an Enzyme Involved in the Synthesis of Hypusine, Are Associated with a Neurodevelopmental Disorder. 
  • Reciprocal connections between the zona incerta and the pretectum and superior colliculus of the cat. 
  • Recognition of lysine-rich peptide ligands by murine cortactin SH3 domain: CD, ITC, and NMR studies. 
  • Regulation of Kv1 subunit expression in oligodendrocyte progenitor cells and their role in G1/S phase progression of the cell cycle. 
  • Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications. 
  • Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitination. 
  • Regulation of translation and transcription of messenger RNA during early embryonic development. 
  • Release of ubiquitin-charged Cdc34-S - Ub from the RING domain is essential for ubiquitination of the SCF(Cdc4)-bound substrate Sic1. 
  • Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO. 
  • SCF E3-mediated autoubiquitination negatively regulates activity of Cdc34 E2 but plays a nonessential role in the catalytic cycle in vitro and in vivo. 
  • SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion. 
  • SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. 
  • SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease. 
  • Selective mutations in cloned and expressed alpha-macroglobulin receptor binding fragment alter binding to either the alpha2-macroglobulin signaling receptor or the low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor. 
  • Serum carboxymethyl-lysine, disability, and frailty in older persons: the Cardiovascular Health Study. 
  • Specificity in the axonal connections of layer VI neurons in tree shrew striate cortex: evidence for distinct granular and supragranular systems. 
  • Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis. 
  • Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa. 
  • Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs. 
  • Structural mechanism of Staphylococcus aureus Hfq binding to an RNA A-tract. 
  • Structure and binding of the H4 histone tail and the effects of lysine 16 acetylation. 
  • Structure of macromolecular aggregates. I. Aggregation-induced conformational changes in polypeptides. 
  • Structure of macromolecular aggregates. II. Construction of model membranes from phospholipids and polypeptides. 
  • Studies of the molecular pathogenesis of hexane neuropathy. II. Evidence that pyrrole derivatization of lysyl residues leads to protein crosslinking. 
  • Studies on the function of the non-primer tRNAs associated with the 70 S RNA of avian myeloblastosis virus. 
  • The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins. 
  • The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk. 
  • The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2. 
  • The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. 
  • The carboxyl-terminal amino acids render pro-human LC3B migration similar to lipidated LC3B in SDS-PAGE. 
  • The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes. 
  • The effect of divalent cations on the conformation and function of human plasminogen. 
  • The importance of the preactivation peptide in the two-stage mechanism of human plasminogen activation. 
  • The laminar origin and distribution of the crossed tectoreticular pathways. 
  • The lipid lysyl-phosphatidylglycerol is present in membranes of Rhizobium tropici CIAT899 and confers increased resistance to polymyxin B under acidic growth conditions. 
  • The mechanical stability of ubiquitin is linkage dependent. 
  • The role of lysine 55 in determining the specificity of the purine repressor for its operators through minor groove interactions. 
  • The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. 
  • The structure of a CREB bZIP.somatostatin CRE complex reveals the basis for selective dimerization and divalent cation-enhanced DNA binding. 
  • The tau N279K exon 10 splicing mutation recapitulates frontotemporal dementia and parkinsonism linked to chromosome 17 tauopathy in a mouse model. 
  • The ubiquitin-conjugating enzyme (E2) Ube2w ubiquitinates the N terminus of substrates. 
  • Thermodynamics, kinetics, and mechanism of the stepwise dissociation and formation of Tris(L-lysinehydroxamato)iron(III) in aqueous acid. 
  • Transport interactions of cystine and dibasic amino acids in isolated rat renal tubules. 
  • Tunable leuko-polymersomes that adhere specifically to inflammatory markers. 
  • Turnip yellow mosaic virus as a chemoaddressable bionanoparticle. 
  • Two proteins of gene A of psiX174. 
  • UbcH5 Interacts with Substrates to Participate in Lysine Selection with the E3 Ubiquitin Ligase CHIP. 
  • Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors. 
  • Ultrastructural features and synaptic connections of hilar ectopic granule cells in the rat dentate gyrus are different from those of granule cells in the granule cell layer. 
  • V2-Directed Vaccine-like Antibodies from HIV-1 Infection Identify an Additional K169-Binding Light Chain Motif with Broad ADCC Activity. 
  • Water adsorption at two unsolvated peptides with a protonated lysine residue: from self-solvation to solvation. 
  • X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription. 
  • cis-acting DNA from fission yeast centromeres mediates histone H3 methylation and recruitment of silencing factors and cohesin to an ectopic site. 
  • p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis. 
  • trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1. 
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  Keywords of People

  • Guan, Ziqiang, Research Professor in Biochemistry, Biochemistry
  • Hirschey, Matthew, Associate Professor of Medicine, Pharmacology & Cancer Biology
  • Turner, Dennis Alan, Professor of Neurosurgery, Biomedical Engineering