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Subject Areas on Research
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A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation.
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A Lamina-Associated Domain Border Governs Nuclear Lamina Interactions, Transcription, and Recombination of the Tcrb Locus.
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A Lysine Residue Essential for Geminivirus Replication Also Controls Nuclear Localization of the Tomato Yellow Leaf Curl Virus Rep Protein.
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A Prob(e)able Route to Lysine Acylation.
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A chemical method for labeling lysine methyltransferase substrates.
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A fine line between molecular umbrella transport and ionophoric activity.
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A high resolution structure of an inhibitor complex of the extracellular nuclease of Staphylococcus aureus. I. Experimental procedures and chain tracing.
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A noncanonical function of sortase enables site-specific conjugation of small molecules to lysine residues in proteins.
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A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation.
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ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia.
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Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract.
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AcK-knowledge reversible acetylation.
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Acetylation goes global: the emergence of acetylation biology.
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Activation of human plasminogen by urokinase. Partial characterization of a pre-activation peptide.
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Active glycation in neurofibrillary pathology of Alzheimer disease: N(epsilon)-(carboxymethyl) lysine and hexitol-lysine.
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Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117.
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Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance.
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Amino acid uptake by isolated renal brush border membrane vesicles in various buffers.
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An examination of adaptive reversion in Saccharomyces cerevisiae.
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An inner activation gate controls TMEM16F phospholipid scrambling.
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An on-line archive of reconstructed hippocampal neurons.
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Anatomy of disturbed sleep in pallido-ponto-nigral degeneration.
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Association of calmodulin and smooth muscle myosin light chain kinase: application of a label selection technique with trace acetylated calmodulin.
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Association of increased spontaneous mutation rates with high levels of transcription in yeast.
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BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers.
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Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages.
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Chaperone-mediated 26S proteasome remodeling facilitates free K63 ubiquitin chain production and aggresome clearance.
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Characteristics of cystine uptake by cultured LLC-PK1 cells.
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Characteristics of lysine transport by isolated rat renal cortical tubule fragments.
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Characteristics of lysine uptake by isolated renal cortical tubule fragments from mature and immature dogs.
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Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking.
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Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation.
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Cloning and sequencing of V genes from anti-osteosarcoma monoclonal antibodies TP-1 and TP-3: location of lysine residues and implications for radiolabeling.
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Consensus guidelines for the diagnosis and management of pyridoxine-dependent epilepsy due to α-aminoadipic semialdehyde dehydrogenase deficiency.
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Constitutive proteasome-mediated turnover of Bfl-1/A1 and its processing in response to TNF receptor activation in FL5.12 pro-B cells convert it into a prodeath factor.
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Course and laminar origin of the tectoparabigeminal pathway.
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Cystine and lysine transport in cultured human renal epithelial cells.
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Cystine-glutamate transport interactions in rat renal cortical tubules, brushborder vesicles, and cultured renal tubule cells.
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Decreased expression of lysyl hydroxylase 2 (LH2) in skin fibroblasts from three Ehlers-Danlos patients does not result from mutations in either the coding or proximal promoter region of the LH2 gene.
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Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice.
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Delta-like 1-Lysine613 regulates notch signaling.
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Desensitization and Incomplete Recovery of Hepatic Target Genes After Chronic Thyroid Hormone Treatment and Withdrawal in Male Adult Mice.
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Design, expression, and immunogenicity of a soluble HIV trimeric envelope fragment adopting a prefusion gp41 configuration.
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Development of magnetic resonance imaging contrast material for in vivo mapping of tissue transglutaminase activity.
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Developmental pattern of cystine transport in isolated rat renal tubules.
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Dipeptidyl peptidase IV (DPP IV/CD26) is a cell-surface plasminogen receptor.
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Directed evolution of a new catalytic site in 2-keto-3-deoxy-6-phosphogluconate aldolase from Escherichia coli.
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Disinhibition in rat superior colliculus mediated by GABAc receptors.
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Disruption of Acetyl-Lysine Turnover in Muscle Mitochondria Promotes Insulin Resistance and Redox Stress without Overt Respiratory Dysfunction.
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Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver.
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Domain structure and DNA binding regions of beta protein from bacteriophage lambda.
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Effect of FSH on protein biosynthesis in testes of the immature rat.
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Effect of lysine and threonine deficient and supplement rice diets on lipids of hepatic smooth and rough endoplasmic reticulum of rats.
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Effect of tissue transglutaminase on the solubility of proteins containing expanded polyglutamine repeats.
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Efficient sporulation of yeast in media buffered near pH6.
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Evidence for separate pathways within the tecto-geniculate projection in the tree shrew.
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Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure.
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Fibrinolysis and fibrinogenolysis by Val442-plasmin.
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Free pentosidine and neopterin as markers of progression rate in diabetic nephropathy. Collaborative Study Group.
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Functional asymmetry of transmembrane segments in nicotinic acetylcholine receptors.
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Gene A of X174. 1. Isolation and identification of its products.
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Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns.
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Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci.
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Hemoglobin Rahere, a human hemoglobin variant with amino acid substitution at the 2,3-diphosphoglycerate binding site. Functional consequences of the alteration and effects of bezafibrate on the oxygen bindings.
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Hemoglobin providence. Functional consequences of two alterations of the 2,3-diphosphoglycerate binding site at position beta 82.
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Hepatic mitochondrial membrane lipid environment and protein nutrition.
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Hepatic phosphatidylcholine synthesis in deficiency of lysine and threonine: effect of malathion.
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Heterogeneous basis of the type VIB form of Ehlers-Danlos syndrome (EDS VIB) that is unrelated to decreased collagen lysyl hydroxylation.
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High-level misincorporation of lysine for arginine at AGA codons in a fusion protein expressed in Escherichia coli.
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Hippocampal mossy fiber sprouting and synapse formation after status epilepticus in rats: visualization after retrograde transport of biocytin.
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Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications.
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Histone Lactylation: A New Role for Glucose Metabolism.
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Histone deacetylase 6 (HDAC6) promotes the pro-survival activity of 14-3-3ζ via deacetylation of lysines within the 14-3-3ζ binding pocket.
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Histone lysine methyltransferase SDG8 is involved in brassinosteroid-regulated gene expression in Arabidopsis thaliana.
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Homocystine uptake in isolated rat renal cortical tubules.
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Hydrolysis by somatic angiotensin-I converting enzyme of basic dipeptides from a cholecystokinin/gastrin and a LH-RH peptide extended at the C-terminus with gly-Arg/Lys-arg, but not from diarginyl insulin.
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Identification of a key lysine residue in heat shock protein 90 required for azole and echinocandin resistance in Aspergillus fumigatus.
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Identification of deacetylase substrates with the biotin switch approach.
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Identification of epsilon-N-trimethyllysine in a rat testis calcium-dependent regulatory protein of cyclic nucleotide phosphodiesterase.
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Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein.
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Interlaminar connections of the superior colliculus in the tree shrew. I. The superficial gray layer.
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Interlaminar connections of the superior colliculus in the tree shrew. II: Projections from the superficial gray to the optic layer.
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Interlaminar connections of the superior colliculus in the tree shrew. III: The optic layer.
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Intragenic regulation of the synthesis of phi chi 174 gene A proteins.
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Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH.
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K63 polyubiquitination is a new modulator of the oxidative stress response.
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Kinetic analysis of the zinc-dependent deacetylase in the lipid A biosynthetic pathway.
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Kinetic role of helix caps in protein folding is context-dependent.
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Laminar origin of ipsilateral tectopontine pathways.
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Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila.
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Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds.
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Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers.
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Lysine glutarylation is a protein posttranslational modification regulated by SIRT5.
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Lysine hydroxylation of collagen in a fibroblast cell culture system.
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Lysine modifications and autophagy.
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Lysine restricted diet for pyridoxine-dependent epilepsy: first evidence and future trials.
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Lysine(164)alpha of protein farnesyltransferase is important for both CaaX substrate binding and catalysis.
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MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation.
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Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.
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Mass spectrometry- and lysine amidination-based protocol for thermodynamic analysis of protein folding and ligand binding interactions.
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Measuring acetyl-CoA and acetylated histone turnover in vivo: Effect of a high fat diet.
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Megalin mediates renal uptake of heavy metal metallothionein complexes.
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Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation.
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Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width.
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Methylation of histone H4 lysine 20 by PR-Set7 ensures the integrity of late replicating sequence domains in Drosophila.
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Mixed function oxidases in response to quality and quantity of dietary protein.
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Modification of fibrinogen by homocysteine thiolactone increases resistance to fibrinolysis: a potential mechanism of the thrombotic tendency in hyperhomocysteinemia.
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Modulation of tissue repair by regeneration enhancer elements.
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Molecular abnormalities of human plasminogen isolated from synovial fluid of rheumatoid arthritis patients.
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Morphometric and electrical properties of reconstructed hippocampal CA3 neurons recorded in vivo.
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Motility-indole-lysine medium for presumptive identification of enteric pathogens of Enterobacteriaceae.
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Motility-indole-lysine-sulfide medium.
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Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma.
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Myelin basic protein stimulates plasminogen activation via tissue plasminogen activator following binding to independent l-lysine-containing domains.
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NMDA receptor antagonists disinhibit rat posterior cingulate and retrosplenial cortices: a potential mechanism of neurotoxicity.
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NMR structure note: solution structure of the core domain of MESD that is essential for proper folding of LRP5/6.
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Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders.
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Nitric oxide-generating polymers reduce platelet adhesion and smooth muscle cell proliferation.
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Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases.
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Nonspecific interstitial pneumonia, alveolar proteinosis, and abnormal proprotein trafficking resulting from a spontaneous mutation in the surfactant protein C gene.
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Novel chimeric spermidine synthase-saccharopine dehydrogenase gene (SPE3-LYS9) in the human pathogen Cryptococcus neoformans.
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Optical Control of CRISPR/Cas9 Gene Editing.
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Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the proliferation of muscle precursor cells by an epigenetic mechanism.
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Polyubiquitin Chains Linked by Lysine Residue 48 (K48) Selectively Target Oxidized Proteins In Vivo.
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Progressive mitochondrial protein lysine acetylation and heart failure in a model of Friedreich's ataxia cardiomyopathy.
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Protein biosynthesis in the testis. 3. Dual effect of glucose.
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Protein biosynthesis in the testis. I. Comparison between stimulation by FSH and glucose.
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Protein biosynthesis in the testis. II. Role of adenosine triphosphate (ATP) in stimulation by glucose.
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Protein imperfections: separating intrinsic from extrinsic variation of torsion angles.
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Proteinase binding and inhibition by the monomeric alpha-macroglobulin rat alpha 1-inhibitor-3.
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Proteome-wide analysis reveals widespread lysine acetylation of major protein complexes in the malaria parasite.
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Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation.
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Proteomic identification and functional characterization of MYH9, Hsc70, and DNAJA1 as novel substrates of HDAC6 deacetylase activity.
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Purification and some properties of the Glu- and Lys-human plasmin heavy chains.
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Quantitative and morphological analysis of dentate granule cells with recurrent basal dendrites from normal and epileptic rats.
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RNA editing generates tissue-specific sodium channels with distinct gating properties.
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Rapid cross-linking of elastin-like polypeptides with (hydroxymethyl)phosphines in aqueous solution.
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Rates of induction of specific translatable messenger RNAs for ovalbumin and avidin by steroid hormones.
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Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes.
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Recessive Rare Variants in Deoxyhypusine Synthase, an Enzyme Involved in the Synthesis of Hypusine, Are Associated with a Neurodevelopmental Disorder.
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Reciprocal connections between the zona incerta and the pretectum and superior colliculus of the cat.
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Recognition of lysine-rich peptide ligands by murine cortactin SH3 domain: CD, ITC, and NMR studies.
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Regulation of Kv1 subunit expression in oligodendrocyte progenitor cells and their role in G1/S phase progression of the cell cycle.
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Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications.
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Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitination.
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Regulation of translation and transcription of messenger RNA during early embryonic development.
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Release of ubiquitin-charged Cdc34-S - Ub from the RING domain is essential for ubiquitination of the SCF(Cdc4)-bound substrate Sic1.
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Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO.
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SCF E3-mediated autoubiquitination negatively regulates activity of Cdc34 E2 but plays a nonessential role in the catalytic cycle in vitro and in vivo.
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SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.
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SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks.
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SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease.
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Selective mutations in cloned and expressed alpha-macroglobulin receptor binding fragment alter binding to either the alpha2-macroglobulin signaling receptor or the low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor.
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Serum carboxymethyl-lysine, disability, and frailty in older persons: the Cardiovascular Health Study.
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Specificity in the axonal connections of layer VI neurons in tree shrew striate cortex: evidence for distinct granular and supragranular systems.
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Spermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression.
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Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis.
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Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa.
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Structural mechanism of Staphylococcus aureus Hfq binding to an RNA A-tract.
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Structure and binding of the H4 histone tail and the effects of lysine 16 acetylation.
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Structure of macromolecular aggregates. I. Aggregation-induced conformational changes in polypeptides.
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Structure of macromolecular aggregates. II. Construction of model membranes from phospholipids and polypeptides.
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Studies of the molecular pathogenesis of hexane neuropathy. II. Evidence that pyrrole derivatization of lysyl residues leads to protein crosslinking.
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Studies on the function of the non-primer tRNAs associated with the 70 S RNA of avian myeloblastosis virus.
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The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins.
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The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk.
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The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2.
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The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.
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The carboxyl-terminal amino acids render pro-human LC3B migration similar to lipidated LC3B in SDS-PAGE.
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The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes.
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The effect of divalent cations on the conformation and function of human plasminogen.
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The importance of the preactivation peptide in the two-stage mechanism of human plasminogen activation.
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The laminar origin and distribution of the crossed tectoreticular pathways.
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The lipid lysyl-phosphatidylglycerol is present in membranes of Rhizobium tropici CIAT899 and confers increased resistance to polymyxin B under acidic growth conditions.
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The mechanical stability of ubiquitin is linkage dependent.
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The role of lysine 55 in determining the specificity of the purine repressor for its operators through minor groove interactions.
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The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present.
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The structure of a CREB bZIP.somatostatin CRE complex reveals the basis for selective dimerization and divalent cation-enhanced DNA binding.
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The tau N279K exon 10 splicing mutation recapitulates frontotemporal dementia and parkinsonism linked to chromosome 17 tauopathy in a mouse model.
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The ubiquitin-conjugating enzyme (E2) Ube2w ubiquitinates the N terminus of substrates.
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Thermodynamics, kinetics, and mechanism of the stepwise dissociation and formation of Tris(L-lysinehydroxamato)iron(III) in aqueous acid.
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Timing of therapy and neurodevelopmental outcomes in 18 families with pyridoxine-dependent epilepsy.
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Transport interactions of cystine and dibasic amino acids in isolated rat renal tubules.
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Tunable leuko-polymersomes that adhere specifically to inflammatory markers.
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Turnip yellow mosaic virus as a chemoaddressable bionanoparticle.
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Two proteins of gene A of psiX174.
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UbcH5 Interacts with Substrates to Participate in Lysine Selection with the E3 Ubiquitin Ligase CHIP.
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Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.
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Ubiquitination regulates the neuroprotective function of the deubiquitinase ataxin-3 in vivo.
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Ultrastructural features and synaptic connections of hilar ectopic granule cells in the rat dentate gyrus are different from those of granule cells in the granule cell layer.
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V2-Directed Vaccine-like Antibodies from HIV-1 Infection Identify an Additional K169-Binding Light Chain Motif with Broad ADCC Activity.
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Water adsorption at two unsolvated peptides with a protonated lysine residue: from self-solvation to solvation.
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X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription.
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p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis.
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pH dependence of the Slc4a11-mediated H+
conductance is influenced by intracellular lysine residues and modified by disease-linked mutations.
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trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1.
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Keywords of People