Macrophage Activation

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  Subject Areas on Research

  • A novel immunomodulatory protein from Poria cocos induces Toll-like receptor 4-dependent activation within mouse peritoneal macrophages. 
  • AIF-1 in the activated smooth muscle cell : spectator or participant? 
  • Aging alters macrophage properties in human skeletal muscle both at rest and in response to acute resistance exercise. 
  • Alopecia in IL-10-deficient mouse pups is c-kit-dependent and can be triggered by iron deficiency. 
  • Alpha 2-macroglobulin 'fast' forms inhibit superoxide production by activated macrophages. 
  • Alpha 2-macroglobulin binds CpG oligodeoxynucleotides and enhances their immunostimulatory properties by a receptor-dependent mechanism. 
  • Altered cell-averaged microviscosity of murine peritoneal macrophages undergoing activation in vivo or in vitro. 
  • Antibody-dependent cytolysis (ADCC) of tumor cells by activated murine macrophages is a two-step process: quantification of target binding and subsequent target lysis. 
  • Aryl Hydrocarbon Receptor Signaling Controls CD155 Expression on Macrophages and Mediates Tumor Immunosuppression. 
  • Atrial fibrillation after cardiac surgery/cardiopulmonary bypass is associated with monocyte activation. 
  • Autophagy links inflammasomes to atherosclerotic progression. 
  • Beryllium fluoride-induced cell proliferation: a process requiring P21(ras)-dependent activated signal transduction and NF-kappaB-dependent gene regulation. 
  • Brief Report: Macrophage Activation in HIV-Infected Adolescent Males Contributes to Differential Bone Loss by Sex: Adolescent Trials Network Study 021. 
  • CX3CR1-dependent renal macrophage survival promotes Candida control and host survival. 
  • CaMKK2: a novel target for shaping the androgen-regulated tumor ecosystem. 
  • Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: comparison to high-fat diet. 
  • Changes in macrophages and their functions with aging in C57BL/6J, AKR/J, and SJL/J mice. 
  • Characterization of NO and cytokine production in immune-activated microglia and peritoneal macrophages derived from a mouse model expressing the human NOS2 gene on a mouse NOS2 knockout background. 
  • Control of Intestinal Inflammation, Colitis-Associated Tumorigenesis, and Macrophage Polarization by Fibrinogen-Like Protein 2. 
  • Cytokine profiling using monocytes/macrophages cultured on common biomaterials with a range of surface chemistries. 
  • Cytosolic phospholipase A(2) activity associated with nuclei is not inhibited by arachidonyl trifluoromethyl ketone in macrophages stimulated with receptor-recognized forms of alpha(2)-macroglobulin. 
  • Dietary nitrate attenuates renal ischemia-reperfusion injuries by modulation of immune responses and reduction of oxidative stress. 
  • Differential messenger ribonucleic acid expression in aggressive versus linear periprosthetic osteolysis. 
  • Discovery of a novel Toxoplasma gondii conoid-associated protein important for parasite resistance to reactive nitrogen intermediates. 
  • Early Endometriosis in Females Is Directed by Immune-Mediated Estrogen Receptor α and IL-6 Cross-Talk. 
  • Effect of cytofectins on the immune response of murine macrophages to mammalian DNA. 
  • Effects of antifungal agents and gamma interferon on macrophage cytotoxicity for fungi and tumor cells. 
  • Effects of bacterial lipopolysaccharide on the hydrolysis of phosphatidylinositol-4,5-bisphosphate in murine peritoneal macrophages. 
  • Effects of oxidized LDL on mononuclear phagocytes: inhibition of induction of four inflammatory cytokine gene RNAs, release of NO, and cytolysis of tumor cells. 
  • Effects of progesterone and estradiol sex hormones on the release of microparticles by RAW 264.7 macrophages stimulated by Poly(I:C). 
  • Essential role for Smad3 in regulating MCP-1 expression and vascular inflammation. 
  • Etiology of osteolysis around porous-coated cementless total hip arthroplasties. 
  • Exosomes Produced by Mesenchymal Stem Cells Drive Differentiation of Myeloid Cells into Immunosuppressive M2-Polarized Macrophages in Breast Cancer. 
  • Fine ambient particles induce oxidative stress and metal binding genes in human alveolar macrophages. 
  • Full Spectrum of LPS Activation in Alveolar Macrophages of Healthy Volunteers by Whole Transcriptomic Profiling. 
  • Functional alterations of macrophages in autoimmune MRL-lpr/lpr mice. 
  • Gene expression profiles of RAW264.7 macrophages stimulated with preparations of LPS differing in isolation and purity. 
  • Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses. 
  • Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS. 
  • Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE₂. 
  • Heterotrimeric Galphaq11 co-immunoprecipitates with surface-anchored GRP78 from plasma membranes of alpha2M*-stimulated macrophages. 
  • Human Mesenchymal Stem Cell-Educated Macrophages Are a Distinct High IL-6-Producing Subset that Confer Protection in Graft-versus-Host-Disease and Radiation Injury Models. 
  • IFNgamma primes macrophages for inflammatory activation by high molecular weight hyaluronan. 
  • Identification of myeloid cell subsets in murine lungs using flow cytometry. 
  • Immune Reconstitution but Persistent Activation After 48 Weeks of Antiretroviral Therapy in Youth With Pre-Therapy CD4 >350 in ATN 061. 
  • Immune control of tuberculosis by IFN-gamma-inducible LRG-47. 
  • Impaired macrophage function underscores susceptibility to Salmonella in mice lacking Irgm1 (LRG-47). 
  • Inducible nitric oxide synthase expression by peritoneal macrophages in endometriosis-associated infertility. 
  • Intact nitric oxide synthase II gene is required for interferon-beta-mediated suppression of growth and metastasis of pancreatic adenocarcinoma. 
  • Interferon (IFN)-alpha activation of human blood mononuclear cells in vitro and in vivo for nitric oxide synthase (NOS) type 2 mRNA and protein expression: possible relationship of induced NOS2 to the anti-hepatitis C effects of IFN-alpha in vivo. 
  • Interferon-mediated protection of B16 melanoma cells from cytotoxicity by activated macrophages. 
  • Laparoscopic surgery and the systemic immune response. 
  • Ligation of the alpha 2-macroglobulin signalling receptor on macrophages induces protein phosphorylation and an increase in cytosolic pH. 
  • Macrophage activation associated with chronic murine cytomegalovirus infection results in more severe experimental choroidal neovascularization. 
  • Macrophage activation by gastric fluid suggests MMP involvement in aspiration-induced lung disease. 
  • Macrophage activation downregulates the degradative capacity of the phagosome. 
  • Macrophage activation results in bone resorption. 
  • Macrophage immunoregulatory pathways in tuberculosis. 
  • Macrophage-derived Hedgehog ligands promotes fibrogenic and angiogenic responses in human schistosomiasis mansoni. 
  • Macrophage-mediated fungistasis: requirement for a macromolecular component in serum. 
  • Macrophages driven to a novel state of activation have anti-inflammatory properties in mice. 
  • Mature macrophage cell lines exhibit variable responses to LPS. 
  • Mechanism of the anti-tumour effect of biochemotherapy in melanoma: preliminary results. 
  • Mechanisms of activation of the RAW264.7 macrophage cell line by transfected mammalian DNA. 
  • Mechanisms of immune stimulation by bacterial DNA. 
  • Microbial translocation induces persistent macrophage activation unrelated to HIV-1 levels or T-cell activation following therapy. 
  • Monocyte activation in patients with age-related macular degeneration: a biomarker of risk for choroidal neovascularization? 
  • Monocyte chemoattractant protein-1 is sufficient for the chemotaxis of monocytes and lymphocytes in transgenic mice but requires an additional stimulus for inflammatory activation. 
  • NF-kappa B as a central mediator in the induction of TGF-beta in monocytes from patients with idiopathic myelofibrosis: an inflammatory response beyond the realm of homeostasis. 
  • NF-κB- and AP-1-mediated DNA looping regulates osteopontin transcription in endotoxin-stimulated murine macrophages. 
  • Neurobiology, cellular and molecular biology, and psychosomatic medicine. 
  • Nitric oxide-mediated intracellular growth restriction of pathogenic Rhodococcus equi can be prevented by iron. 
  • Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses. 
  • Pleural macrophage recruitment and activation in asbestos-induced pleural injury. 
  • Polysaccharides PS-G and protein LZ-8 from Reishi (Ganoderma lucidum) exhibit diverse functions in regulating murine macrophages and T lymphocytes. 
  • Radioprotective effects of amifostine on acute and chronic esophageal injury in rodents. 
  • Redistribution of protein kinase C activity in human monocytes: correlation with activation of the respiratory burst. 
  • Regulation of cytosolic phospholipase A2 activity in macrophages stimulated with receptor-recognized forms of alpha 2-macroglobulin: role in mitogenesis and cell proliferation. 
  • Regulatory B cell production of IL-10 inhibits lymphoma depletion during CD20 immunotherapy in mice. 
  • Relationship between resolution of non-alcoholic steatohepatitis and changes in lipoprotein sub-fractions: a post-hoc analysis of the PIVENS trial. 
  • Resolvin E1 inhibits neuropathic pain and spinal cord microglial activation following peripheral nerve injury. 
  • Role of the heat shock protein 90 in immune response stimulation by bacterial DNA and synthetic oligonucleotides. 
  • Simple and sensitive assay employing stable reagents for quantification of plasminogen activator. 
  • Soluble CD14, CD163, and CD27 biomarkers distinguish ART-suppressed youth living with HIV from healthy controls. 
  • Specific amino acid (L-arginine) requirement for the microbiostatic activity of murine macrophages. 
  • Sperm-macrophage interaction in the mouse: a quantitative assay in vitro using 111indium oxine-labeled sperm. 
  • Structural basis for the proinflammatory cytokine activity of high mobility group box 1. 
  • TRPV4 channels augment macrophage activation and ventilator-induced lung injury. 
  • TT-301 inhibits microglial activation and improves outcome after central nervous system injury in adult mice. 
  • Temporal onset of hypoxia and oxidative stress after pulmonary irradiation. 
  • Tenofovir Has Minimal Effect on Biomarkers of Bone Health in Youth with HIV Receiving Initial Antiretroviral Therapy. 
  • The HIV-1 protease inhibitor nelfinavir activates PP2 and inhibits MAPK signaling in macrophages: a pathway to reduce inflammation. 
  • The immunologic properties of DNA. 
  • The immunomodulatory roles of macrophages at the maternal-fetal interface. 
  • The properties of microparticles from RAW 264.7 macrophage cells undergoing in vitro activation or apoptosis. 
  • The relationship between apoptosis and high-mobility group protein 1 release from murine macrophages stimulated with lipopolysaccharide or polyinosinic-polycytidylic acid. 
  • The translocation of HMGB1 during cell activation and cell death. 
  • Tissue response to particulate polymethylmethacrylate in mice with various immune deficiencies. 
  • Tolerance induced by apoptotic antigen-coupled leukocytes is induced by PD-L1+ and IL-10-producing splenic macrophages and maintained by T regulatory cells. 
  • Toll-like receptor 2-dependent and -independent activation of macrophages by group B streptococci. 
  • Toll-like receptor 4 (TLR4)-deficient murine macrophage cell line as an in vitro assay system to show TLR4-independent signaling of Bacteroides fragilis lipopolysaccharide. 
  • Transfusion-related biologic effects and free hemoglobin, heme, and iron. 
  • Treatment of murine peritoneal macrophages with bacterial lipopolysaccharide alters expression of c-fos and c-myc oncogenes. 
  • Tumor necrosis factor-alpha induces increased hydrogen peroxide production and Fc receptor expression, but not increased Ia antigen expression by peritoneal macrophages. 
  • Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity. 
  • Upregulation of macrophage plasma membrane and nuclear phospholipase D activity on ligation of the alpha2-macroglobulin signaling receptor: involvement of heterotrimeric and monomeric G proteins. 
  • Virulence factors identified by Cryptococcus neoformans mutant screen differentially modulate lung immune responses and brain dissemination. 
  • p47 GTPases regulate Toxoplasma gondii survival in activated macrophages. 
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  Keywords of People

  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Gunn, Michael Dee, Professor of Medicine, Integrative Immunobiology
  • Taylor, Gregory Alan, Professor in Medicine, Integrative Immunobiology