Macular Degeneration

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  Subject Areas on Research

  • 3-D Adaptive Sparsity Based Image Compression With Applications to Optical Coherence Tomography. 
  • 8 Questions with Dr. Moshfeghi. 
  • A 32 kb critical region excluding Y402H in CFH mediates risk for age-related macular degeneration. 
  • A Brief Discussion on Lipid Activated Nuclear Receptors and their Potential Role in Regulating Microglia in Age-Related Macular Degeneration (AMD). 
  • A Non-Canonical Role for β-Secretase in the Retina. 
  • A Phase 1 Study of Intravitreous E10030 in Combination with Ranibizumab in Neovascular Age-Related Macular Degeneration. 
  • A Review of Pathogenic Drivers of Age-Related Macular Degeneration, Beyond Complement, with a Focus on Potential Endpoints for Testing Therapeutic Interventions in Preclinical Studies. 
  • A centrifugal fluidic immunoassay for ocular diagnostics with an enzymatically hydrolyzed fluorogenic substrate. 
  • A functional variant in the CFI gene confers a high risk of age-related macular degeneration. 
  • A hapten generated from an oxidation fragment of docosahexaenoic acid is sufficient to initiate age-related macular degeneration. 
  • A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. 
  • A nationwide cohort study of cigarette smoking and risk of neovascular age-related macular degeneration in East Asian men. 
  • A phase I study of intravitreal vascular endothelial growth factor trap-eye in patients with neovascular age-related macular degeneration. 
  • A pooled case-control study of the apolipoprotein E (APOE) gene in age-related maculopathy. 
  • A prospective study of early intraocular pressure changes after a single intravitreal triamcinolone injection. 
  • A prospective study of treatment patterns and 1-year outcome of Asian age-related macular degeneration and polypoidal choroidal vasculopathy. 
  • A rare penetrant mutation in CFH confers high risk of age-related macular degeneration. 
  • A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration. 
  • A2E Suppresses Regulatory Function of RPE Cells in Th1 Cell Differentiation Via Production of IL-1β and Inhibition of PGE2. 
  • AMD and the alternative complement pathway: genetics and functional implications. 
  • APOE Isoforms Control Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration. 
  • Abnormalities of proteoglycans and glycoproteins synthesized by corneal organ cultures derived from patients with macular corneal dystrophy. 
  • Acute intraocular inflammation after intravitreous injections of bevacizumab for treatment of neovascular age-related macular degeneration. 
  • Adaptation to monocular torsion after macular translocation. 
  • Aflibercept-related sterile inflammation. 
  • Age-related macular degeneration and cancer mortality in the atherosclerosis risk in communities study. 
  • Age-related macular degeneration and cardiovascular disease in the era of anti-vascular endothelial growth factor therapies. 
  • Age-related macular degeneration and incident cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. 
  • Age-related macular degeneration and long-term risk of stroke subtypes. 
  • Age-related macular degeneration and mortality from cardiovascular disease or stroke. 
  • Age-related macular degeneration and polypoidal choroidal vasculopathy in Asians. 
  • Age-related macular degeneration and progression of coronary artery calcium: The Multi-Ethnic Study of Atherosclerosis. 
  • Age-related macular degeneration and risk for stroke. 
  • Age-related macular degeneration and risk of coronary heart disease and stroke: the Cardiovascular Health Study. 
  • Age-related macular degeneration and risk of coronary heart disease: the Atherosclerosis Risk in Communities Study. 
  • Age-related macular degeneration. 
  • Age-related macular degeneration. 
  • Age-related macular degeneration: why should stroke physicians care? 
  • Age-related maculopathy: a genomewide scan with continued evidence of susceptibility loci within the 1q31, 10q26, and 17q25 regions. 
  • Alcohol and eye diseases. 
  • Alcohol consumption and the risk of age-related macular degeneration: a systematic review and meta-analysis. 
  • All-trans-retinal sensitizes human RPE cells to alternative complement pathway-induced cell death. 
  • Amblyopia: is visual loss permanent? 
  • Analysis of Peripapillary Atrophy in Relation to Macular Geographic Atrophy in Age-Related Macular Degeneration. 
  • Analysis of single nucleotide polymorphisms in the NOS2A gene and interaction with smoking in age-related macular degeneration. 
  • Analysis of the Stargardt disease gene (ABCR) in age-related macular degeneration. 
  • Analysis of the indel at the ARMS2 3'UTR in age-related macular degeneration. 
  • Anaphylaxis following intravenous fluorescein angiography in a vitreoretinal clinic: report of 4 cases. 
  • Angiotensin II-induced MMP-2 activity and MMP-14 and basigin protein expression are mediated via the angiotensin II receptor type 1-mitogen-activated protein kinase 1 pathway in retinal pigment epithelium: implications for age-related macular degeneration. 
  • Angiotensin II-induced hypertension regulates AT1 receptor subtypes and extracellular matrix turnover in mouse retinal pigment epithelium. 
  • Anti-VEGF treatment patterns for neovascular age-related macular degeneration among medicare beneficiaries. 
  • Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration. 
  • Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathy. 
  • Apolipoprotein E gene and early age-related maculopathy: the Atherosclerosis Risk in Communities Study. 
  • Apolipoprotein e gene and age-related maculopathy in older individuals: the cardiovascular health study. 
  • Are antioxidants or other supplements protective for age-related macular degeneration? 
  • Are lung disease and function related to age-related macular degeneration? 
  • Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology. 
  • Aryl hydrocarbon receptor knock-out exacerbates choroidal neovascularization via multiple pathogenic pathways. 
  • Asian age-related macular degeneration phenotyping study: rationale, design and protocol of a prospective cohort study. 
  • Association of Baseline Characteristics and Early Vision Response with 2-Year Vision Outcomes in the Comparison of AMD Treatments Trials (CATT). 
  • Association of Low Luminance Questionnaire With Objective Functional Measures in Early and Intermediate Age-Related Macular Degeneration. 
  • Association of dilated retinal arteriolar caliber with early age-related macular degeneration: the Handan Eye Study. 
  • Association of genetic variants on 8p21 and 4q12 with age-related macular degeneration in Asian populations. 
  • Association of the apolipoprotein E gene with age-related macular degeneration: possible effect modification by family history, age, and gender. 
  • Association of vitamin D deficiency and age-related macular degeneration in medicare beneficiaries. 
  • Associations between cardiovascular risk factors and early age-related macular degeneration in a rural Chinese adult population. 
  • Associations of candidate genes to age-related macular degeneration among racial/ethnic groups in the multi-ethnic study of atherosclerosis. 
  • Associations of eye diseases and symptoms with self-reported physical and mental health. 
  • Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13. 
  • Author response: additional considerations in the utility of dark adaptometry for the diagnosis of age-related macular degeneration. 
  • Autoimmune biomarkers in age-related macular degeneration: a possible role player in disease development and progression. 
  • Bacterial contamination of needles used for intravitreal injections: a prospective, multicenter study. 
  • Basal laminar deposit formation in APO B100 transgenic mice: complex interactions between dietary fat, blue light, and vitamin E. 
  • Baseline characteristics, the 25-Item National Eye Institute Visual Functioning Questionnaire, and their associations in the Complications of Age-Related Macular Degeneration Prevention Trial (CAPT). 
  • Bilateral macular vitelliform lesions in a thrombocytopenic patient. 
  • Biology of p62/sequestosome-1 in Age-Related Macular Degeneration (AMD). 
  • Blood-derived macrophages infiltrate the retina and activate Muller glial cells under experimental choroidal neovascularization. 
  • Blue light induced A2E oxidation in rat eyes--experimental animal model of dry AMD. 
  • Bmp6 regulates retinal iron homeostasis and has altered expression in age-related macular degeneration. 
  • Bone marrow transplantation transfers age-related susceptibility to neovascular remodeling in murine laser-induced choroidal neovascularization. 
  • C-reactive protein and age-related macular degeneration and cataract: the singapore malay eye study. 
  • C3 R102G polymorphism increases risk of age-related macular degeneration. 
  • CFH and VIPR2 as susceptibility loci in choroidal thickness and pachychoroid disease central serous chorioretinopathy. 
  • CKD increases the risk of age-related macular degeneration. 
  • Calibration of fundus images using spectral domain optical coherence tomography. 
  • Cataract surgery in patients with cataract and age related macular degeneration: do the benefits outweigh the risks? 
  • Categorizing the effect of comorbidity: a qualitative study of individuals' experiences in a low-vision rehabilitation program. 
  • Cell death in age-related macular degeneration. 
  • Central and pericentral retinal sensitivity after macular translocation surgery. 
  • Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD. 
  • Change in visual function after macular translocation with 360 degrees retinectomy for neovascular age-related macular degeneration. 
  • Changes in abdominal obesity and age-related macular degeneration: the Atherosclerosis Risk in Communities Study. 
  • Changing trends of blindness: the initial harvest from translational public health and clinical research in ophthalmology. 
  • Characteristics and Predictors of Early and Delayed Responders to Ranibizumab Treatment in Neovascular Age-Related Macular Degeneration: A Retrospective Analysis from the ANCHOR, MARINA, HARBOR, and CATT Trials. 
  • Choosing Core Outcomes for Use in Clinical Trials in Ophthalmology: Perspectives from Three Ophthalmology Outcomes Working Groups. 
  • Choosing a Time Horizon in Cost and Cost-effectiveness Analyses. 
  • Choroidal Remodeling in Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy: A 12-month Prospective Study. 
  • Cigarette smoke-related hydroquinone induces filamentous actin reorganization and heat shock protein 27 phosphorylation through p38 and extracellular signal-regulated kinase 1/2 in retinal pigment epithelium: implications for age-related macular degeneration. 
  • Cigarette smoke-related oxidants and the development of sub-RPE deposits in an experimental animal model of dry AMD. 
  • Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration. 
  • Ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degeneration. 
  • Circulating Autoantibodies in Age-Related Macular Degeneration Recognize Human Macular Tissue Antigens Implicated in Autophagy, Immunomodulation, and Protection from Oxidative Stress and Apoptosis. 
  • Clinical Relevance and Application of the Age-Related Eye Disease Study Severity Scale for Age-Related Macular Degeneration. 
  • Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis. 
  • Clinical update: new treatments for age-related macular degeneration. 
  • Clinicopathologic correlation of spontaneous retinal pigment epithelial tears with choroidal neovascular membranes in age-related macular degeneration. 
  • Clinicopathologic studies of eyes that were obtained postmortem from four patients who were enrolled in the submacular surgery trials: SST Report No. 16. 
  • Combined superior oblique muscle recession and inferior oblique muscle advancement and transposition for cyclotorsion associated with macular translocation surgery. 
  • Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. 
  • Comorbid cognitive impairment and functional trajectories in low vision rehabilitation for macular disease. 
  • Comorbidity of age-related macular degeneration with Alzheimer's disease: A histopathologic case-control study. 
  • Comparative analysis of circulating endothelial progenitor cells in age-related macular degeneration patients using automated rare cell analysis (ARCA) and fluorescence activated cell sorting (FACS). 
  • Comparing age-related macular degeneration phenotype in probands from singleton and multiplex families. 
  • Comparison of color fundus photographs and fundus autofluorescence images in measuring geographic atrophy area. 
  • Comparison of optical coherence tomography assessments in the comparison of age-related macular degeneration treatments trials. 
  • Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation. 
  • Complement factor H in AMD: Bridging genetic associations and pathobiology. 
  • Complement factor H increases risk for atrophic age-related macular degeneration. 
  • Complement factor H variant increases the risk of age-related macular degeneration. 
  • Complement-Mediated Regulation of Apolipoprotein E in Cultured Human RPE Cells. 
  • Computational modeling of retinal hypoxia and photoreceptor degeneration in patients with age-related macular degeneration. 
  • Consensus Definition for Atrophy Associated with Age-Related Macular Degeneration on OCT: Classification of Atrophy Report 3. 
  • Contact lens filter for macular photocoagulation with monochromatic green argon laser. 
  • Correlation of Color Fundus Photograph Grading with Risks of Early Age-related Macular Degeneration by using Automated OCT-derived Drusen Measurements. 
  • Correlation of pathologic features in spectral domain optical coherence tomography with conventional retinal studies. 
  • Cost-effectiveness of bevacizumab and ranibizumab for newly diagnosed neovascular macular degeneration (an American Ophthalmological Society thesis). 
  • Cystoid macular edema occurring 13 years after cataract extraction. 
  • DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. 
  • Decreased membrane complement regulators in the retinal pigmented epithelium contributes to age-related macular degeneration. 
  • Decreased visual acuity associated with cystoid macular edema in neovascular age-related macular degeneration. 
  • Delayed macular choriocapillary circulation in age-related macular degeneration. 
  • Deletion of CFHR3 and CFHR1 genes in age-related macular degeneration. 
  • Deletion of the transmembrane protein Prom1b in zebrafish disrupts outer-segment morphogenesis and causes photoreceptor degeneration. 
  • Depressive symptoms and age-related macular degeneration in older people: the cardiovascular health study. 
  • Description of the Age-Related Eye Disease Study 9-step severity scale applied to participants in the Complications of Age-related Macular Degeneration Prevention Trial. 
  • Detailed analysis of allelic variation in the ABCA4 gene in age-related maculopathy. 
  • Developing SDOCT to assess donor human eyes prior to tissue sectioning for research. 
  • Development and Course of Scars in the Comparison of Age-Related Macular Degeneration Treatments Trials. 
  • Diagnostic sensitivity and specificity of dark adaptometry for detection of age-related macular degeneration. 
  • Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis. 
  • Dietary glycemic index and the risk of age-related macular degeneration. 
  • Dietary omega-3 fatty acid and fish intake in the primary prevention of age-related macular degeneration: a systematic review and meta-analysis. 
  • Differential associations of myopia with major age-related eye diseases: the Singapore Indian Eye Study. 
  • Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration. 
  • Drusen Volume and Retinal Pigment Epithelium Abnormal Thinning Volume Predict 2-Year Progression of Age-Related Macular Degeneration. 
  • Drusen ultrastructure imaging with spectral domain optical coherence tomography in age-related macular degeneration. 
  • Dry age-related macular degeneration: mechanisms, therapeutic targets, and imaging. 
  • Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD. 
  • EFFICACY AND SAFETY OF INTRAVITREAL AFLIBERCEPT AND RANIBIZUMAB IN ASIAN PATIENTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: Subgroup Analyses From the VIEW Trials. 
  • Early age-related macular degeneration, cognitive function, and dementia: the Cardiovascular Health Study. 
  • Education, socio-economic status and age-related macular degeneration in Asians: the Singapore Malay Eye Study. 
  • Effect of simvastatin on retinal vascular caliber: the Age-Related Maculopathy Statin Study. 
  • Effects of simvastatin on retinal structure and function of a high-fat atherogenic mouse model of thickened Bruch's membrane. 
  • Emerging evidence concerning systemic safety of anti-VEGF agents--should ophthalmologists be concerned? 
  • Emerging roles for nuclear receptors in the pathogenesis of age-related macular degeneration. 
  • Emphysema, airflow limitation, and early age-related macular degeneration. 
  • Esterified and unesterified cholesterol in drusen and basal deposits of eyes with age-related maculopathy. 
  • Estimated cases of blindness and visual impairment from neovascular age-related macular degeneration avoided in Australia by ranibizumab treatment. 
  • Estimated cases of legal blindness and visual impairment avoided using ranibizumab for choroidal neovascularization: non-Hispanic white population in the United States with age-related macular degeneration. 
  • Estimates of incidence rates with longitudinal claims data. 
  • Estrogen receptor beta protects against in vivo injury in RPE cells. 
  • Ethnic Differences in the Association Between Age-Related Macular Degeneration and Vision-Specific Functioning. 
  • Ethnic variation in early age-related macular degeneration lesions between white Australians and Singaporean Asians. 
  • Evaluation of a Remote Diagnosis Imaging Model vs Dilated Eye Examination in Referable Macular Degeneration. 
  • Evaluation of clustering and genotype distribution for replication in genome wide association studies: the age-related eye disease study. 
  • Evaluation of minimum clinically meaningful changes in scores on the National Eye Institute Visual Function Questionnaire (NEI-VFQ) SST Report Number 19. 
  • Evaluation of very high- and very low-dose intravitreal aflibercept in patients with neovascular age-related macular degeneration. 
  • Exclusion of TIMP3 as a candidate locus in age-related macular degeneration. 
  • Exploring the potential role of the oxidant-activated transcription factor aryl hydrocarbon receptor in the pathogenesis of AMD. 
  • Exposure to Atomic Bomb Radiation and Age-Related Macular Degeneration in Later Life: The Hiroshima-Nagasaki Atomic Bomb Survivor Study. 
  • Expression of human complement factor H prevents age-related macular degeneration-like retina damage and kidney abnormalities in aged Cfh knockout mice. 
  • Extraocular muscle surgery for extorsion after macular translocation surgery new surgical technique and clinical management. 
  • Familial aggregation of age-related macular degeneration in the Utah population. 
  • Fast acquisition and reconstruction of optical coherence tomography images via sparse representation. 
  • Female reproductive factors and major eye diseases in Asian women -the Singapore Malay Eye Study. 
  • Ferroxidase hephaestin's cell-autonomous role in the retinal pigment epithelium. 
  • Five-Year Follow-up of Nonfibrotic Scars in the Comparison of Age-Related Macular Degeneration Treatments Trials. 
  • Fixation switch and diplopia after full macular translocation surgery. 
  • Frequency and risk factors of non-retinopathy ocular conditions in people with diabetes: the Singapore Malay Eye Study. 
  • Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6. 
  • Functional changes after photodynamic therapy with verteporfin. 
  • Functional decline in older adults. 
  • Gaps in receipt of regular eye examinations among medicare beneficiaries diagnosed with diabetes or chronic eye diseases. 
  • Genetic Polymorphisms of CFH and ARMS2 Do Not Predict Response to Antioxidants and Zinc in Patients with Age-Related Macular Degeneration: Independent Statistical Evaluations of Data from the Age-Related Eye Disease Study. 
  • Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration. 
  • Genetic determinants of age-related macular degeneration in diverse populations from the PAGE study. 
  • Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits. 
  • Genetic variants linked to myopic macular degeneration in persons with high myopia: CREAM Consortium. 
  • Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. 
  • Genome-wide association study and meta-analysis of intraocular pressure. 
  • Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). 
  • Genotype-phenotype correlations and differential diagnosis in autosomal dominant macular disease. 
  • Geographic atrophy in age-related macular degeneration and TLR3. 
  • Global causes of blindness and distance vision impairment 1990-2020: a systematic review and meta-analysis. 
  • Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. 
  • Global prevalence of visual impairment associated with myopic macular degeneration and temporal trends from 2000 through 2050: systematic review, meta-analysis and modelling. 
  • HDL-cholesterol levels and risk of age-related macular degeneration: a multiethnic genetic study using Mendelian randomization. 
  • HORIZON: an open-label extension trial of ranibizumab for choroidal neovascularization secondary to age-related macular degeneration. 
  • Haplotypes spanning the complement factor H gene are protective against age-related macular degeneration. 
  • Health- and vision-related quality of life among patients with choroidal neovascularization secondary to age-related macular degeneration at enrollment in randomized trials of submacular surgery: SST report no. 4. 
  • Health-protective and adverse effects of the apolipoprotein E epsilon2 allele in older men. 
  • Heparan sulfate, including that in Bruch's membrane, inhibits the complement alternative pathway: implications for age-related macular degeneration. 
  • Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes. 
  • Histopathologic and ultrastructural features of surgically excised subfoveal choroidal neovascular lesions: submacular surgery trials report no. 7. 
  • Human complement factor H Y402H polymorphism causes an age-related macular degeneration phenotype and lipoprotein dysregulation in mice. 
  • Human pharyngeal microbiota in age-related macular degeneration. 
  • Hyperopic refractive error and shorter axial length are associated with age-related macular degeneration: the Singapore Malay Eye Study. 
  • Hypotrichosis with juvenile macular dystrophy: a case report with molecular study. 
  • Identifying the content area for the 51-item National Eye Institute Visual Function Questionnaire: results from focus groups with visually impaired persons. 
  • Identity of pigmented subretinal cells in age-related macular degeneration. 
  • Immune mechanisms in inflammatory and degenerative eye disease. 
  • Impact of early and late age-related macular degeneration on vision-specific functioning. 
  • Impact of fluorescein angiographic characteristics of macular lesions on outcomes after macular translocation 360 degree surgery in eyes with age-related macular degeneration. 
  • Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss. 
  • Improvement in near visual function after macular translocation surgery with 360-degree peripheral retinectomy. 
  • In Vivo Multimodal Imaging of Drusenoid Lesions in Rhesus Macaques. 
  • Incidence and Growth of Geographic Atrophy during 5 Years of Comparison of Age-Related Macular Degeneration Treatments Trials. 
  • Incidence of myocardial infarction, stroke, and death in patients with age-related macular degeneration treated with intravitreal anti-vascular endothelial growth factor therapy. 
  • Incidence of retinal artery occlusion following intravitreal antivascular endothelial growth factor injections. 
  • Incomplete Retinal Pigment Epithelial and Outer Retinal Atrophy in Age-Related Macular Degeneration: Classification of Atrophy Meeting Report 4. 
  • Increased Burden of Vision Impairment and Eye Diseases in Persons with Chronic Kidney Disease - A Population-Based Study. 
  • Independent effects of complement factor H Y402H polymorphism and cigarette smoking on risk of age-related macular degeneration. 
  • Induced corneal astigmatism after macular translocation surgery with scleral infolding. 
  • Inflammation, complement factor h, and age-related macular degeneration: the Multi-ethnic Study of Atherosclerosis. 
  • Influence of myopic macular degeneration severity on treatment outcomes with intravitreal aflibercept in the MYRROR study. 
  • Initial observations of key features of age-related macular degeneration in APOE targeted replacement mice. 
  • Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. 
  • Insulin-like growth factor-1 contributes to neovascularization in age-related macular degeneration. 
  • Interferon gamma-inducible protein-10 (IP-10) and eotaxin as biomarkers in age-related macular degeneration. 
  • Intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration: a short-term study. 
  • Introducing Anti-Vascular Endothelial Growth Factor Therapies for AMD Did Not Raise Risk of Myocardial Infarction, Stroke, and Death. 
  • Inverse association of female hormone replacement therapy with age-related macular degeneration and interactions with ARMS2 polymorphisms. 
  • Iron homeostasis and eye disease. 
  • Iron importers Zip8 and Zip14 are expressed in retina and regulated by retinal iron levels. 
  • Iron toxicity as a potential factor in AMD. 
  • Is Choroidal or Scleral Thickness Related to Myopic Macular Degeneration? 
  • Is age-related macular degeneration a manifestation of systemic disease? New prospects for early intervention and treatment. 
  • Is aspirin intake associated with early age-related macular degeneration? The Singapore Indian Eye Study. 
  • Is bilateral age-related macular degeneration less common in Asians than Caucasians? 
  • Is early age-related macular degeneration associated with cerebral MRI changes? The Atherosclerosis Risk in Communities study. 
  • Is early age-related macular degeneration related to carotid artery stiffness? The Atherosclerosis Risk in Communities Study. 
  • Is early age-related maculopathy related to cognitive function? The Atherosclerosis Risk in Communities Study. 
  • Is our current clinical classification of AMD up to the job? 
  • Is renal function associated with early age-related macular degeneration? 
  • Isolation of Retinal Exosome Biomarkers from Blood by Targeted Immunocapture. 
  • Joint effects of smoking history and APOE genotypes in age-related macular degeneration. 
  • LOC387715/HTRA1 and complement factor H variants in patients with age-related macular degeneration seen at the mayo clinic. 
  • Lack of awareness of common eye conditions in the community. 
  • Lack of the P2X7 receptor protects against AMD-like defects and microparticle accumulation in a chronic oxidative stress-induced mouse model of AMD. 
  • Language processing in age-related macular degeneration associated with unique functional connectivity signatures in the right hemisphere. 
  • Large subretinal hemorrhage after intravitreal bevacizumab (Avastin) for age-related macular degeneration. 
  • Laser treatment in patients with bilateral large drusen: the complications of age-related macular degeneration prevention trial. 
  • Late outgrowth endothelial progenitor cells in patients with age-related macular degeneration. 
  • Length-adaptive graph search for automatic segmentation of pathological features in optical coherence tomography images. 
  • Lens status influences the association between CFH polymorphisms and age-related macular degeneration: findings from two population-based studies in Singapore. 
  • Linkage analysis for age-related macular degeneration supports a gene on chromosome 10q26. 
  • Longitudinal Associations Between Microstructural Changes and Microperimetry in the Early Stages of Age-Related Macular Degeneration. 
  • Longitudinal analysis of reticular drusen associated with geographic atrophy in age-related macular degeneration. 
  • Longitudinal incidence of adverse outcomes of age-related macular degeneration. 
  • Longitudinal prevalence of major eye diseases. 
  • Longitudinal rates of annual eye examinations of persons with diabetes and chronic eye diseases. 
  • Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. 
  • Macular corneal dystrophy. Lack of keratan sulfate in serum and cornea. 
  • Macular degeneration and heart disease. 
  • Macular degeneration: the latest in current surgical management. 
  • Macular morphology and visual acuity in the comparison of age-related macular degeneration treatments trials. 
  • Macular translocation surgery with 360-degree peripheral retinectomy following ocular photodynamic therapy of choroidal neovascularization. 
  • Macular translocation with 360 degrees peripheral retinectomy for geographic atrophy. 
  • Macular translocation with 360-degree peripheral retinectomy impact of technique and surgical experience on visual outcomes. 
  • Macular translocation with radial scleral ouffolding: experimental studies and initial human results. 
  • Maculas affected by age-related macular degeneration contain increased chelatable iron in the retinal pigment epithelium and Bruch's membrane. 
  • Management of ocular torsion and diplopia after macular translocation for age-related macular degeneration: prospective clinical study. 
  • Measurement of macular fractal dimension using a computer-assisted program. 
  • Measuring dark adaptation in the elderly: a predictor of who may develop macular degeneration? 
  • Memory deficit associated with worse functional trajectories in older adults in low-vision rehabilitation for macular disease. 
  • Meta-analysis of genome scans of age-related macular degeneration. 
  • Metabolic syndrome and risk of age-related macular degeneration. 
  • Mitochondrial DNA polymorphism A4917G is independently associated with age-related macular degeneration. 
  • Models of retinal diseases and their applicability in drug discovery. 
  • Molecular genetics of AMD and current animal models. 
  • Monitoring visual status: why patients do or do not comply with practice guidelines. 
  • Monocyte activation in patients with age-related macular degeneration: a biomarker of risk for choroidal neovascularization? 
  • Myopia and cognitive dysfunction: the singapore malay eye study. 
  • Natural History of Drusenoid Pigment Epithelial Detachment Associated with Age-Related Macular Degeneration: Age-Related Eye Disease Study 2 Report No. 17. 
  • Natural History of Geographic Atrophy Progression Secondary to Age-Related Macular Degeneration (Geographic Atrophy Progression Study). 
  • Natural history of subfoveal subretinal hemorrhage in age-related macular degeneration. 
  • Neovascular age-related macular degeneration and its association with LOC387715 and complement factor H polymorphism. 
  • New loci and coding variants confer risk for age-related macular degeneration in East Asians. 
  • Night vision symptoms and progression of age-related macular degeneration in the Complications of Age-related Macular Degeneration Prevention Trial. 
  • North Carolina macular dystrophy (MCDR1) locus: a fine resolution genetic map and haplotype analysis. 
  • North Carolina macular dystrophy (MCDR1). A review and refined mapping to 6q14-q16.2. 
  • North Carolina macular dystrophy is assigned to chromosome 6. 
  • North Carolina macular dystrophy: exclusion map using RFLPs and microsatellites. 
  • North Carolina's dominant progressive foveal dystrophy: how progressive is it? 
  • Nrf2 signaling modulates cigarette smoke-induced complement activation in retinal pigmented epithelial cells. 
  • Nuclear receptors as potential therapeutic targets for age-related macular degeneration. 
  • Nutritional supplements for older adults: review and recommendations--Part II. 
  • Ocular amyloid imaging at the crossroad of Alzheimer's disease and age-related macular degeneration: implications for diagnosis and therapy. 
  • Ocular complications after anti-vascular endothelial growth factor therapy in Medicare patients with age-related macular degeneration. 
  • Ocular conditions associated with peripapillary subretinal neovascularization, their relative frequencies, and associated outcomes. 
  • Optical Coherence Tomography Reflective Drusen Substructures Predict Progression to Geographic Atrophy in Age-related Macular Degeneration. 
  • Optical coherence tomography following photodynamic therapy with verteporfin for subfoveal predominantly classic choroidal neovascularization. 
  • Optical coherence tomography grading reproducibility during the Comparison of Age-related Macular Degeneration Treatments Trials. 
  • Optical coherence tomography reader agreement in neovascular age-related macular degeneration. 
  • Ordered subset linkage analysis supports a susceptibility locus for age-related macular degeneration on chromosome 16p12. 
  • Ordered-subset analysis (OSA) for family-based association mapping of complex traits. 
  • Outer retinal tubulation in the comparison of age-related macular degeneration treatments trials (CATT). 
  • Overall diet quality and age-related macular degeneration. 
  • Oxidative damage-induced inflammation initiates age-related macular degeneration. 
  • Oxidative stress induces mitochondrial dysfunction and a protective unfolded protein response in RPE cells. 
  • Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy. 
  • Oxidized low-density-lipoprotein-induced injury in retinal pigment epithelium alters expression of the membrane complement regulatory factors CD46 and CD59 through exosomal and apoptotic bleb release. 
  • PPAR nuclear receptors and altered RPE lipid metabolism in age-related macular degeneration. 
  • PPARβ/δ selectively regulates phenotypic features of age-related macular degeneration. 
  • Pars plana vitrectomy, subretinal injection of tissue plasminogen activator, and fluid-gas exchange for displacement of thick submacular hemorrhage in age-related macular degeneration. 
  • Pentraxin 3 recruits complement factor H to protect against oxidative stress-induced complement and inflammasome overactivation. 
  • Peripheral reticular pigmentary change is associated with complement factor H polymorphism (Y402H) in age-related macular degeneration. 
  • Pesticide Use and Age-Related Macular Degeneration in the Agricultural Health Study. 
  • Phenome-wide association studies (PheWASs) for functional variants. 
  • Phenotype analysis of patients with the risk variant LOC387715 (A69S) in age-related macular degeneration. 
  • Phenotypic heterogeneity in families with age-related macular degeneration. 
  • Phonemic fluency and brain connectivity in age-related macular degeneration: a pilot study. 
  • Photodynamic therapy and intravitreal triamcinolone for extrafoveal choroidal neovascularization in neovascular age-related macular degeneration. 
  • Photodynamic therapy for predominantly hemorrhagic lesions in neovascular age-related macular degeneration. 
  • Photoreceptor layer thinning over drusen in eyes with age-related macular degeneration imaged in vivo with spectral-domain optical coherence tomography. 
  • Plasma lipoprotein subfraction concentrations are associated with lipid metabolism and age-related macular degeneration. 
  • Polarized Exosome Release from the Retinal Pigmented Epithelium. 
  • Polypoidal Choroidal Vasculopathy: Definition, Pathogenesis, Diagnosis, and Management. 
  • Polypoidal choroidal vasculopathy and systemic lupus erythematosus. 
  • Population-based studies in ophthalmology. 
  • Postmarketing analysis of aflibercept-related sterile intraocular inflammation. 
  • Prevalence and Risk Factors for Nonexudative Neovascularization in Fellow Eyes of Patients With Unilateral Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy. 
  • Prevalence and causes of vision loss in North Africa and Middle East in 2015: magnitude, temporal trends and projections. 
  • Prevalence and causes of vision loss in high-income countries and in Eastern and Central Europe in 2015: magnitude, temporal trends and projections. 
  • Prevalence and clinical correlates of focal choroidal excavation in eyes with age-related macular degeneration, polypoidal choroidal vasculopathy and central serous chorioretinopathy. 
  • Prevalence and patterns of comorbid cognitive impairment in low vision rehabilitation for macular disease. 
  • Prevalence and risk factors for age-related macular degeneration in Indians: a comparative study in Singapore and India. 
  • Prevalence and risk factors for age-related macular degeneration in an adult Japanese population: the Funagata study. 
  • Prevalence of age-related macular degeneration in 4 racial/ethnic groups in the multi-ethnic study of atherosclerosis. 
  • Prevalence of age-related macular degeneration in a Malay population: the Singapore Malay Eye Study. 
  • Prevalence of age-related macular degeneration in a rural Chinese population: the Handan Eye Study. 
  • Prevalence of and risk factors for age-related macular degeneration in a multiethnic Asian cohort. 
  • Prevalence of cataract surgery and visual outcomes in Indian immigrants in Singapore: the Singapore Indian eye study. 
  • Prevalence, Risk Factors, and Impact of Myopic Macular Degeneration on Visual Impairment and Functioning Among Adults in Singapore. 
  • Prevalence, racial variations, and risk factors of age-related macular degeneration in Singaporean Chinese, Indians, and Malays. 
  • Progress on retinal image analysis for age related macular degeneration. 
  • Progression of Geographic Atrophy in Age-related Macular Degeneration: AREDS2 Report Number 16. 
  • Progression of choroidal neovascularization following injection of pegaptanib sodium (macugen) in two eyes with neovascular age-related macular degeneration. 
  • Progression of intermediate age-related macular degeneration with proliferation and inner retinal migration of hyperreflective foci. 
  • Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration. 
  • Proteomics characterization of cell membrane blebs in human retinal pigment epithelium cells. 
  • Pseudoexfoliation syndrome in Icelandic families. 
  • Quality of life after macular translocation with 360 degrees peripheral retinectomy for age-related macular degeneration. 
  • Quantification of Change in Pigment Epithelial Detachment Volume and Morphology After Transition to Intravitreal Aflibercept in Eyes With Recalcitrant Neovascular AMD: 18-Month Results. 
  • Quantification of keratan sulfate in blood as a marker of cartilage catabolism. 
  • Quantitative classification of eyes with and without intermediate age-related macular degeneration using optical coherence tomography. 
  • Quantitative comparison of drusen segmented on SD-OCT versus drusen delineated on color fundus photographs. 
  • Racial difference in the prevalence of epiretinal membrane between Caucasians and Asians. 
  • Randomized Trial to Evaluate Tandospirone in Geographic Atrophy Secondary to Age-Related Macular Degeneration: The GATE Study. 
  • Ranibizumab and bevacizumab for AMD. 
  • Ranibizumab and bevacizumab for neovascular age-related macular degeneration. 
  • Ranibizumab combined with verteporfin photodynamic therapy in neovascular age-related macular degeneration (FOCUS): year 2 results. 
  • Ranibizumab for Age-related Macular Degeneration. 
  • Ranibizumab for neovascular age-related macular degeneration. 
  • Ranibizumab for treatment of neovascular age-related macular degeneration: a phase I/II multicenter, controlled, multidose study. 
  • Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration. 
  • Recombinant Haplotypes Narrow the ARMS2/HTRA1 Association Signal for Age-Related Macular Degeneration. 
  • Recurrence of macular corneal dystrophy within grafts. 
  • Recurrence of retinal pigment epithelial changes after macular translocation with 360 degrees peripheral retinectomy for geographic atrophy. 
  • Recurrent choroidal neovascularization after macular translocation surgery with 360-degree peripheral retinectomy. 
  • Reduced fluorescein angiography and fundus photography use in the management of neovascular macular degeneration and macular edema during the past decade. 
  • Refractive errors and age-related macular degeneration: a systematic review and meta-analysis. 
  • Regulation of age-related macular degeneration-like pathology by complement factor H. 
  • Relationship of smoking and cardiovascular risk factors with polypoidal choroidal vasculopathy and age-related macular degeneration in Chinese persons. 
  • Reply. 
  • Research resource: nuclear receptor atlas of human retinal pigment epithelial cells: potential relevance to age-related macular degeneration. 
  • Responsiveness of the National Eye Institute Visual Function Questionnaire to changes in visual acuity: findings in patients with subfoveal choroidal neovascularization--SST Report No. 1. 
  • Rethinking Nuclear Receptors as Potential Therapeutic Targets for Retinal Diseases. 
  • Reticular drusen associated with geographic atrophy in age-related macular degeneration. 
  • Reticular pseudodrusen are subretinal drusenoid deposits. 
  • Retinal arteriolar wall signs and early age-related macular degeneration: the singapore malay eye study. 
  • Retinal microenvironment imbalance in dry age-related macular degeneration: a mini-review. 
  • Retinal phenotypes in patients homozygous for the G1961E mutation in the ABCA4 gene. 
  • Retinal pigment epithelial cell death by the alternative complement cascade: role of membrane regulatory proteins, calcium, PKC, and oxidative stress. 
  • Retinal pigment epithelial degeneration, partial retinal atrophy and macular hole in acute lymphocytic leukemia. 
  • Retinal pigment epithelial detachments in age-related macular degeneration: classification and therapeutic options. 
  • Retinal pigment epithelial tear with vitreomacular attachment: a novel pathogenic feature. 
  • Retinal pigment epithelium and microglia express the CD5 antigen-like protein, a novel autoantigen in age-related macular degeneration. 
  • Retinal pigment epithelium response to oxidant injury in the pathogenesis of early age-related macular degeneration. 
  • Retinal vascular caliber and age-related macular degeneration in an Indian population from Singapore. 
  • Retinal vascular caliber and age-related macular degeneration: the Singapore Malay Eye Study. 
  • Retinal vascular changes following intravitreal ranibizumab injections for neovascular AMD over a 1-year period. 
  • Retinal vessel wall signs and the 5 year incidence of age related maculopathy: the Blue Mountains Eye Study. 
  • Retrospective review of eyes with neovascular age-related macular degeneration treated with photodynamic therapy with verteporfin and intravitreal triamcinolone. 
  • Review of key findings from the Singapore Malay Eye Study (SiMES-1). 
  • Risks of mortality, myocardial infarction, bleeding, and stroke associated with therapies for age-related macular degeneration. 
  • STARGARDT DISEASE: Beyond Flecks and Atrophy. 
  • Screening for Impaired Visual Acuity in Older Adults: US Preventive Services Task Force Recommendation Statement. 
  • Semiautomated image processing method for identification and quantification of geographic atrophy in age-related macular degeneration. 
  • Senile macular degeneration: clinical, histopathological, and ultrastructural studies. 
  • Serum leptin and age-related macular degeneration. 
  • Seven new loci associated with age-related macular degeneration. 
  • Shared genetic variants for polypoidal choroidal vasculopathy and typical neovascular age-related macular degeneration in East Asians. 
  • Six-Year Incidence and Risk Factors of Age-Related Macular Degeneration in Singaporean Indians: The Singapore Indian Eye Study. 
  • Six-Year Incidence of Age-Related Macular Degeneration in Asian Malays: The Singapore Malay Eye Study. 
  • Six-week outcomes after pegaptanib. 
  • Smoking, cardiovascular risk factors, and age-related macular degeneration in Asians: the Singapore Malay Eye Study. 
  • Spatial correlation between hyperpigmentary changes on color fundus photography and hyperreflective foci on SDOCT in intermediate AMD. 
  • Spectral domain optical coherence tomography imaging of geographic atrophy margins. 
  • Spectral-domain optical coherence tomography characteristics of intermediate age-related macular degeneration. 
  • Statins and age-related macular degeneration: time for a randomized controlled trial? 
  • Strabismus surgery for large-angle cyclotorsion after macular translocation surgery. 
  • Strong labeling for iron and the iron-handling proteins ferritin and ferroportin in the photoreceptor layer in age-related macular degeneration. 
  • Sub-retinal drusenoid deposits in human retina: organization and composition. 
  • Subclinical atherosclerotic cardiovascular disease and early age-related macular degeneration in a multiracial cohort: the Multiethnic Study of Atherosclerosis. 
  • Subgroup analysis of the MARINA study of ranibizumab in neovascular age-related macular degeneration. 
  • Submacular surgery trials randomized pilot trial of laser photocoagulation versus surgery for recurrent choroidal neovascularization secondary to age-related macular degeneration: I. Ophthalmic outcomes submacular surgery trials pilot study report number 1. 
  • Submacular surgery trials randomized pilot trial of laser photocoagulation versus surgery for recurrent choroidal neovascularization secondary to age-related macular degeneration: II. Quality of life outcomes submacular surgery trials pilot study report number 2. 
  • Successful macular translocation with temporary scleral infolding using absorbable sture. 
  • Suppression of aberrant choroidal neovascularization through activation of the aryl hydrocarbon receptor. 
  • Surgical treatment of age-related macular degeneration. 
  • Sustained visual acuity loss in the comparison of age-related macular degeneration treatments trials. 
  • Systematic Functional Testing of Rare Variants: Contributions of CFI to Age-Related Macular Degeneration. 
  • Systemic markers of inflammation, endothelial dysfunction, and age-related maculopathy. 
  • Systemic, Ocular and Genetic Risk Factors for Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Singaporeans. 
  • T cells and macrophages responding to oxidative damage cooperate in pathogenesis of a mouse model of age-related macular degeneration. 
  • Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature. 
  • Targeting age-related macular degeneration with Alzheimer's disease based immunotherapies: anti-amyloid-beta antibody attenuates pathologies in an age-related macular degeneration mouse model. 
  • Ten-year incidence of age-related macular degeneration according to diabetic retinopathy classification among medicare beneficiaries. 
  • The ARMS2 A69S variant and bilateral advanced age-related macular degeneration. 
  • The apolipoprotein E epsilon2 allele and aging-associated health deterioration in older males. 
  • The association of cataract and cataract surgery with the long-term incidence of age-related maculopathy: the Beaver Dam eye study. 
  • The association of prior cytomegalovirus infection with neovascular age-related macular degeneration. 
  • The epidemiology of age related eye diseases in Asia. 
  • The eye in hypertension. 
  • The eye: A window to the soul of the immune system. 
  • The fibroblast growth factor receptors, FGFR-1 and FGFR-2, mediate two independent signalling pathways in human retinal pigment epithelial cells. 
  • The natural history and prognosis of neovascular age-related macular degeneration: a systematic review of the literature and meta-analysis. 
  • The oxidative stress product carboxyethylpyrrole potentiates TLR2/TLR1 inflammatory signaling in macrophages. 
  • The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited. 
  • The prevalence of age-related macular degeneration in Asians: a systematic review and meta-analysis. 
  • The relation of retinal microvascular characteristics to age-related eye disease: the Beaver Dam eye study. 
  • The relationship between birthweight and early age-related maculopathy: the atherosclerosis risk in communities study. 
  • The role of complement dysregulation in AMD mouse models. 
  • The role of dynamic indocyanine green angiography in the diagnosis and treatment of retinal angiomatous proliferation. 
  • Time Horizons in Cost Analyses-Reply. 
  • Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. 
  • Toll-like receptor polymorphisms and age-related macular degeneration. 
  • Topography of geographic atrophy in age-related macular degeneration. 
  • Towards automatic detection of age-related macular degeneration in retinal fundus images. 
  • Treatment of neovascular age-related macular degeneration with intravitreal bevacizumab: efficacy of three consecutive monthly injections. 
  • Trends in Cost of Major Eye Diseases to Medicare, 1991 to 2000 
  • Ultra-high resolution spectral domain optical coherence tomography of traumatic maculopathy. 
  • Ultrastructure and clinicopathologic correlation of idiopathic preretinal macular fibrosis. 
  • Understanding indocyanine green angiography in polypoidal choroidal vasculopathy: the group experience with digital fundus photography and confocal scanning laser ophthalmoscopy. 
  • Unraveling a multifactorial late-onset disease: from genetic susceptibility to disease mechanisms for age-related macular degeneration. 
  • Update on multi-center clinical trials in the United States. 
  • Urinary Isoprostane Levels and Age-Related Macular Degeneration. 
  • Using genetic variation and environmental risk factor data to identify individuals at high risk for age-related macular degeneration. 
  • VISUAL FUNCTION MEASURES IN EARLY AND INTERMEDIATE AGE-RELATED MACULAR DEGENERATION. 
  • Validated automatic segmentation of AMD pathology including drusen and geographic atrophy in SD-OCT images. 
  • Vision Impairment in CKD Patients: Epidemiology, Mechanisms, Differential Diagnoses, and Prevention. 
  • Vision-related quality of life in patients with bilateral severe age-related macular degeneration. 
  • Visual impairment, age-related eye diseases, and cognitive function: the Singapore Malay Eye study. 
  • Visual outcomes following macular translocation with 360-degree peripheral retinectomy. 
  • Whole-exome sequencing implicates UBE3D in age-related macular degeneration in East Asian populations. 
• 

  Keywords of People

  • Bowes Rickman, Catherine, Professor of Ophthalmology, Cell Biology
  • Curtis, Lesley H., Professor in Population Health Sciences, Medicine, General Internal Medicine
  • Farsiu, Sina, Paul Ruffin Scarborough Distinguished Associate Professor of Engineering, Electrical and Computer Engineering
  • Fekrat, Sharon, Professor of Ophthalmology, Ophthalmology, Vitreoretinal Diseases & Surgery
  • Liu, Yutao, Adjunct Assistant Professor in the Department of Medicine, Medicine, Medical Genetics
  • McDonnell, Donald Patrick, Chair, Department of Pharmacology & Cancer Biology, Duke Innovation & Entrepreneurship
  • Mruthyunjaya, Prithvi, Adjunct Associate Professor in the Department of Ophthalmology, Ophthalmology, Vitreoretinal Diseases & Surgery
  • Stinnett, Sandra Sue, Associate Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics
  • Toth, Cynthia Ann, Joseph A.C. Wadsworth Distinguished Professor of Ophthalmology, Biomedical Engineering