Mammary Glands, Animal

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  Subject Areas on Research

  • A mouse model engineered to conditionally express the progesterone receptor-B isoform. 
  • Absolute photoacoustic thermometry in deep tissue. 
  • Akt is required for Stat5 activation and mammary differentiation. 
  • Analysis of prognostic variables which influence early and long-term response of pet animal tumors to radiation alone and radiation plus heat. 
  • Analysis of sites phosphorylated on acetyl-CoA carboxylase in response to insulin in isolated adipocytes. Comparison with sites phosphorylated by casein kinase-2 and the calmodulin-dependent multiprotein kinase. 
  • Assessment of the immune capacity of mammary epithelial cells: comparison with mammary tissue after challenge with Escherichia coli. 
  • Autocrine prolactin induced by the Pten-Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways. 
  • Biological responses to TGF-β in the mammary epithelium show a complex dependency on Smad3 gene dosage with important implications for tumor progression. 
  • Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6). 
  • Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli, but S. aureus fails to both activate NF-kappaB in mammary epithelial cells and to quickly induce TNFalpha and interleukin-8 (CXCL8) expression in the udder. 
  • Consumption of Mediterranean versus Western Diet Leads to Distinct Mammary Gland Microbiome Populations. 
  • Development of mammary hyperplasia and neoplasia in MMTV-TGF alpha transgenic mice. 
  • Developmental stratification of the mammary epithelium occurs through symmetry-breaking vertical divisions of apically positioned luminal cells. 
  • Distinctive patterns of hyperplasia in transgenic mice with mouse mammary tumor virus transforming growth factor-alpha. Characterization of mammary gland and skin proliferations. 
  • Divalent cation activation of galactosyltransferase in native mammary Golgi vesicles. 
  • Dynamic contrast-enhanced MR microscopy identifies regions of therapeutic response in a preclinical model of colorectal adenocarcinoma. 
  • ENaC- and CFTR-dependent ion and fluid transport in mammary epithelia. 
  • Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques. 
  • Effects of an oral contraceptive combination with or without androgen on mammary tissues: a study in rats. 
  • Electrophoretic evaluation of sera from dogs with cancer. 
  • Escherichia coli, but not Staphylococcus aureus triggers an early increased expression of factors contributing to the innate immune defense in the udder of the cow. 
  • Frequency-dependent absorption of electromagnetic energy in biological tissue. 
  • Homology analysis of the protein sequences of fatty acid synthases from chicken liver, rat mammary gland, and yeast. 
  • Hyperosmotic stress stimulates promoter activity and regulates cellular utilization of the serum- and glucocorticoid-inducible protein kinase (Sgk) by a p38 MAPK-dependent pathway. 
  • IRE1 phosphatase PP2Ce regulates adaptive ER stress response in the postpartum mammary gland. 
  • Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-beta 1. 
  • Integrin-linked kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells. 
  • In Vivo Effects of Long-Term Cigarette Smoke Exposure on Mammary Tissue in Mice. 
  • Isolation and purification of cellular retinol binding protein (CRBP) from goat mammary gland. 
  • Lymphocyte activation, cell-mediated cytotoxicity and their relationship to dietary fat-enhanced mammary tumorigenesis in C3H/OUJ mice. 
  • Mammary gland morphology in Sprague-Dawley rats following treatment with an organochlorine mixture in utero and neonatal genistein. 
  • Microwave power absorption differences between normal and malignant tissue. 
  • Molecular epidemiology of Staphylococcus aureus mastitis in dairy heifers. 
  • NF-kappaB factors are essential, but not the switch, for pathogen-related induction of the bovine beta-defensin 5-encoding gene in mammary epithelial cells. 
  • Neutrophil gelatinase-associated lipocalin in normal and neoplastic human tissues. Cell type-specific pattern of expression. 
  • Optical Imaging of Glucose Uptake and Mitochondrial Membrane Potential to Characterize Her2 Breast Tumor Metabolic Phenotypes. 
  • Preclinical and clinical evaluation of intraductally administered agents in early breast cancer. 
  • Prolactin receptor signal transduction pathways and actions determined in prolactin receptor knockout mice. 
  • Regulation of lipoprotein lipase activity and mRNA in the mammary gland of the lactating mouse. 
  • Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation. 
  • Sexually dimorphic BDNF signaling directs sensory innervation of the mammary gland. 
  • Singular value decomposition-based regression identifies activation of endogenous signaling pathways in vivo. 
  • Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development. 
  • Tenascin-C inhibits extracellular matrix-dependent gene expression in mammary epithelial cells. Localization of active regions using recombinant tenascin fragments. 
  • The role of phosphorylation/dephosphorylation of acetyl-CoA carboxylase in the regulation of mammalian fatty acid biosynthesis. 
  • The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex. 
  • Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression. 
  • Use of Sepharose 4B for preparative scale fractionation of eukaryotic messenger RNA's. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Freemark, Michael Scott, Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine, Pediatrics, Endocrinology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology