Mammals

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  Subject Areas on Research

  • 29 mammalian genomes reveal novel exaptations of mobile elements for likely regulatory functions in the human genome. 
  • A Roadmap to Heart Regeneration Through Conserved Mechanisms in Zebrafish and Mammals. 
  • A Scalable, Multiplexed Assay for Decoding GPCR-Ligand Interactions with RNA Sequencing. 
  • A comparative study of crosslinked and noncrosslinked fibrin from the major classes of vertebrates. 
  • A high-resolution map of human evolutionary constraint using 29 mammals. 
  • A mathematical model of circadian rhythms and dopamine. 
  • A new duck genome reveals conserved and convergently evolved chromosome architectures of birds and mammals. 
  • A preliminary analysis of correlated evolution in Mammalian chewing motor patterns. 
  • A preliminary analysis of correlations between chewing motor patterns and mandibular morphology across mammals. 
  • A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. 
  • A radiation of arboreal basal eutherian mammals beginning in the Late Cretaceous of India. 
  • A timecourse analysis of systemic and gonadal effects of temperature on sexual development of the red-eared slider turtle Trachemys scripta elegans. 
  • Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals. 
  • Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation. 
  • An integrated encyclopedia of DNA elements in the human genome. 
  • An invertebrate model of the developmental neurotoxicity of insecticides: effects of chlorpyrifos and dieldrin in sea urchin embryos and larvae. 
  • Analysis of Cdc6 function in the assembly of mammalian prereplication complexes. 
  • Ant Olfaction: Smells Like an Insect, Develops Like a Mammal. 
  • Antifungal effects of cyclosporine and FK 506 are mediated via immunophilin-dependent calcineurin inhibition. 
  • Architectural pattern, tissue and cellular morphology in livers of fishes: relationship to experimentally-induced neoplastic responses. 
  • Attempted molecular detection of the thermally dimorphic human fungal pathogen Emergomyces africanus in terrestrial small mammals in South Africa. 
  • Baby Genomics: Tracing the Evolutionary Changes That Gave Rise to Placentation. 
  • Backbone and sidechain 1H, 15N and 13C resonance assignments of the free and RNA-bound tandem zinc finger domain of the tristetraprolin family member from Selaginella moellendorffii. 
  • Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway. 
  • Balancing acts: molecular control of mammalian iron metabolism. 
  • Behavioural and physiological limits to vision in mammals. 
  • Best practices for germ-free derivation and gnotobiotic zebrafish husbandry. 
  • Biomechanics of mammalian feeding and primate evolution 
  • Body Mass and Tail Girth Predict Hibernation Expression in Captive Dwarf Lemurs. 
  • Bone-associated gene evolution and the origin of flight in birds. 
  • C. elegans as a model to study glial development. 
  • Capturing the primordial Kras mutation initiating urethane carcinogenesis. 
  • Cardiorespiratory coupling in cetaceans; a physiological strategy to improve gas exchange? 
  • Carolina critters: a collection of camera-trap data from wildlife surveys across North Carolina. 
  • Cell fate commitment during mammalian sex determination. 
  • Cell type- and species-specific host responses to Toxoplasma gondii and its near relatives. 
  • Cell-Cycle Regulators and Cell Death in Immunity. 
  • Cellular plasticity: 1712 to the present day. 
  • Cellular response to endoplasmic reticulum stress: a matter of life or death. 
  • Centromeres of human chromosomes. 
  • Characterization and expression of a rice RAD23 gene. 
  • Characterizing the phylogenetic specialism-generalism spectrum of mammal parasites. 
  • China's endemic vertebrates sheltering under the protective umbrella of the giant panda. 
  • Cilia proteins are biomarkers of altered flow in the vasculature. 
  • Cloning of a cDNA encoding bovine erythropoietin and analysis of its transcription in selected tissues. 
  • Cloning of human and mouse brain cDNAs coding for S1, the second member of the mammalian elongation factor-1 alpha gene family: analysis of a possible evolutionary pathway. 
  • Comparative Genomic Analysis of the Pheromone Receptor Class 1 Family (V1R) Reveals Extreme Complexity in Mouse Lemurs (Genus, Microcebus) and a Chromosomal Hotspot across Mammals. 
  • Comparative genomics of mammalian hibernators using gene networks. 
  • Comparing effectiveness of experimental and implemented bycatch reduction measures: the ideal and the real. 
  • Concentration-Dependent Recruitment of Mammalian Odorant Receptors. 
  • Conservation: forest fragments, facts, and fallacies. 
  • Conserved microRNA program as key to mammalian cardiac regeneration: insights from zebrafish. 
  • Craniodental and humeral morphology of a new species of Masrasector (Teratodontinae, Hyaenodonta, Placentalia) from the late Eocene of Egypt and locomotor diversity in hyaenodonts. 
  • DNA replication origins-where do we begin? 
  • DNA replication. 
  • Deadly diving? Physiological and behavioural management of decompression stress in diving mammals. 
  • Deconstructing mammalian thermoregulation. 
  • Deep diving mammals: Dive behavior and circulatory adjustments contribute to bends avoidance. 
  • Defining origins of replication in mammalian cells. 
  • Determination of the functional domain organization of the importin alpha nuclear import factor. 
  • Discs of mammalian rod photoreceptors form through the membrane evagination mechanism. 
  • Divergent regulation of protein synthesis in the cytosol and endoplasmic reticulum compartments of mammalian cells. 
  • Do animals living in larger groups experience greater parasitism? A meta-analysis. 
  • Dynamic evolution of the alpha (α) and beta (β) keratins has accompanied integument diversification and the adaptation of birds into novel lifestyles. 
  • Earliest record of Platychoerops (Primates, Plesiadapidae), a new species from Mouras Quarry, Mont de Berru, France. 
  • Effect of urban habitat use on parasitism in mammals: a meta-analysis. 
  • Effects of body size on estimation of mammalian area requirements. 
  • Effects of land use, habitat characteristics, and small mammal community composition on Leptospira prevalence in northeast Madagascar. 
  • Effects of stochastic sodium channels on extracellular excitation of myelinated nerve fibers. 
  • Endangered species hold clues to human evolution. 
  • Energetic cost of locomotion in animals. 
  • Epithelial/mesenchymal interactions and branching morphogenesis of the lung. 
  • Estimating parasite host range. 
  • Eukaryotic Sexual Reproduction Evoked "with a Little Help from My Friends". 
  • Evaluating and enhancing ribozyme reaction efficiency in mammalian cells. 
  • Evidence for a single loss of mineralized teeth in the common avian ancestor. 
  • Evidence for a tradeoff between retention time and chewing efficiency in large mammalian herbivores. 
  • Evidence for nutrient-dependent regulation of the COPII coat by O-GlcNAcylation. 
  • Evolution and development of the mammalian dentition: insights from the marsupial Monodelphis domestica. 
  • Evolution of fungal sex chromosomes. 
  • Evolution. Fossils versus clocks. 
  • Excision repair is required for genotoxin-induced mutagenesis in mammalian cells. 
  • Expanding the test set: Chemicals with potential to disrupt mammalian brain development. 
  • Experimental determination of rates of concerted evolution. 
  • Expression of heterogeneous nuclear ribonucleoprotein A2/B1 changes with critical stages of mammalian lung development. 
  • Expression, purification, and in vitro assays of mitochondrial single-stranded DNA-binding protein. 
  • Faunal assemblage composition and paleoenvironment of Plovers Lake, a Middle Stone Age locality in Gauteng Province, South Africa. 
  • Flow cytometric analysis of DNA content in budding yeast. 
  • Fueling the flames: Mammalian programmed necrosis in inflammatory diseases. 
  • Functional analysis of a mammalian odorant receptor subfamily. 
  • Functional and evolutionary aspects of axial stability in euarchontans and other mammals. 
  • Functional expression of the multidrug resistance-associated protein in the yeast Saccharomyces cerevisiae. 
  • Fxr signaling and microbial metabolism of bile salts in the zebrafish intestine. 
  • G protein-coupled receptor kinases. 
  • Gene Expression Profiling in the Hibernating Primate, Cheirogaleus Medius. 
  • Genetic approaches to access cell types in mammalian nervous systems. 
  • Genetic variance in fitness indicates rapid contemporary adaptive evolution in wild animals. 
  • Getting to the heart of regeneration in zebrafish. 
  • Global Mammal Parasite Database version 2.0. 
  • Global patterns of marine mammal, seabird, and sea turtle bycatch reveal taxa-specific and cumulative megafauna hotspots. 
  • Gnotobiotic zebrafish reveal evolutionarily conserved responses to the gut microbiota. 
  • Great ranging associated with greater reproductive investment in mammals. 
  • Have gene knockouts caused evolutionary reversals in the mammalian first arch? 
  • Hormone-dependent interaction between the amino- and carboxyl-terminal domains of progesterone receptor in vitro and in vivo. 
  • Host longevity and parasite species richness in mammals. 
  • Hot Spot Mutagenesis Improves the Functional Expression of Unique Mammalian Odorant Receptors. 
  • How mammalian predation contributes to tropical tree community structure. 
  • How to protect half of Earth to ensure it protects sufficient biodiversity. 
  • Human dectin-1 deficiency and mucocutaneous fungal infections. 
  • Identification and characterization of two Ca2+/CaM-dependent protein kinases required for normal nuclear division in Aspergillus nidulans. 
  • Identification of a new subclass of Alu DNA repeats which can function as estrogen receptor-dependent transcriptional enhancers. 
  • Increased grassland arthropod production with mammalian herbivory and eutrophication: a test of mediation pathways. 
  • Induction of stable RNA interference in mammalian cells. 
  • Infectious diseases and extinction risk in wild mammals. 
  • Inhibition of p53 Sulfoconjugation Prevents Oxidative Hepatotoxicity and Acute Liver Failure. 
  • Inter-stride variability triggers gait transitions in mammals and birds. 
  • Interactions among key residues regulate mammalian odorant receptor trafficking. 
  • Intrinsic activity of human immunodeficiency virus type 1 protease heterologous fusion proteins in mammalian cells. 
  • Intrinsic hand proportions of euarchontans and other mammals: implications for the locomotor behavior of plesiadapiforms. 
  • Intronic cis-regulatory modules mediate tissue-specific and microbial control of angptl4/fiaf transcription. 
  • Involvement of the HERV-derived cell-fusion inhibitor, suppressyn, in the fusion defects characteristic of the trisomy 21 placenta. 
  • Is RNA interference a physiologically relevant innate antiviral immune response in mammals? 
  • Joint angular excursions during cyclical behaviors differ between tetrapod feeding and locomotor systems. 
  • Leadership in Mammalian Societies: Emergence, Distribution, Power, and Payoff. 
  • Lifting baselines to address the consequences of conservation success. 
  • Ligand-dependent and -independent function of the transactivation regions of the human estrogen receptor in yeast. 
  • MESH1 knockdown triggers proliferation arrest through TAZ repression. 
  • Male-mediated prenatal loss: Functions and mechanisms. 
  • Mammalian RAFT1 kinase domain provides rapamycin-sensitive TOR function in yeast. 
  • Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. 
  • Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans. 
  • Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators. 
  • Mammalian and Drosophila blood: JAK of all trades? 
  • Mammalian molar complexity follows simple, predictable patterns. 
  • Mammalian odorant receptors: functional evolution and variation. 
  • Mammalian sexual differentiation: lessons from the spotted hyena. 
  • Mammals and rainfall: paleoecology of the middle Miocene at La Venta (Colombia, South America). 
  • Measurement of 25-hydroxyvitamin D 1-alpha-hydroxylase activity in mammalian kidney. 
  • Mechanisms of inbreeding avoidance in a wild primate. 
  • Mechanisms of protein prenylation and role in G protein function. 
  • Megafauna and ecosystem function from the Pleistocene to the Anthropocene. 
  • Microbial nitrogen limitation in the mammalian large intestine. 
  • Microparasites and Placental Invasiveness in Eutherian Mammals. 
  • Missense mutation (G480C) in the CFTR gene associated with protein mislocalization but normal chloride channel activity. 
  • Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis. 
  • Modeling the excitability of mammalian nerve fibers: influence of afterpotentials on the recovery cycle. 
  • Modulation of Xenogeneic T-cell Proliferation by B7 and mTOR Blockade of T Cells and Porcine Endothelial Cells. 
  • Molecular Clocks without Rocks: New Solutions for Old Problems. 
  • Molecular insights into mechanisms of iron transport. 
  • Molecular phylogeny of the kinesin family of microtubule motor proteins. 
  • Morphometric characteristics of cells in the alveolar region of mammalian lungs. 
  • Moving in the Anthropocene: Global reductions in terrestrial mammalian movements. 
  • Mutualism or parasitism? Using a phylogenetic approach to characterize the oxpecker-ungulate relationship. 
  • Network calisthenics: control of E2F dynamics in cell cycle entry. 
  • New bedfellows in the mammalian sex-determination affair. 
  • New postcrania of Deccanolestes from the Late Cretaceous of India and their bearing on the evolutionary and biogeographic history of euarchontan mammals. 
  • Non-human primates avoid the detrimental effects of prenatal androgen exposure in mixed-sex litters: combined demographic, behavioral, and genetic analyses. 
  • Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export pathway. 
  • Odorant receptors and desensitization proteins colocalize in mammalian sperm. 
  • On sexual dimorphism in immune function. 
  • Ongoing electrical activity of superior cervical ganglion cells in mammals of different size. 
  • Ontogenetic changes to metacarpal trabecular bone structure in mountain and western lowland gorillas. 
  • Organ protective mechanisms common to extremes of physiology: a window through hibernation biology. 
  • Organization of the superior olivary complex in the guinea pig. I. Cytoarchitecture, cytochrome oxidase histochemistry, and dendritic morphology. 
  • Origin of bistability underlying mammalian cell cycle entry. 
  • Overview of FEED, the feeding experiments end-user database. 
  • Oxidative stress in toxicology: established mammalian and emerging piscine model systems. 
  • Oxygen dissociation curve of echidna blood. 
  • Parasite resistance and the adaptive significance of sleep. 
  • Phosphorylated MED1 links transcription recycling and cancer growth. 
  • Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations. 
  • Phylogenetic analysis of the ecology and evolution of mammalian sleep. 
  • Phylogenetic analysis of vertebrate lactate dehydrogenase (LDH) multigene families. 
  • Pioneering paradigms and magnificent manifestos--Leigh Van Valen's priceless contributions to evolutionary biology. 
  • Platypus and echidna genomes reveal mammalian biology and evolution. 
  • Polypeptides of endogenous avian C-type viruses: their detection in the plasma membrane of normal and infected cells. 
  • Primate origins, human origins, and the end of higher taxa. 
  • Principles and applications of a Tat-based assay for analyzing specific RNA-protein interactions in mammalian cells. 
  • Protein kinases that phosphorylate activated G protein-coupled receptors. 
  • Protein serine/threonine phosphatases--new avenues for cell regulation. 
  • Pulmonary ventilation-perfusion mismatch: a novel hypothesis for how diving vertebrates may avoid the bends. 
  • RNA Interference in Mammals: The Virus Strikes Back. 
  • RNA regulons: coordination of post-transcriptional events. 
  • RTP family members induce functional expression of mammalian odorant receptors. 
  • Random Wiring, Ganglion Cell Mosaics, and the Functional Architecture of the Visual Cortex. 
  • Regulation of overexpressed hexokinases in liver and islet cells. 
  • Regulation of the cell cycle by calcium and calmodulin. 
  • Remotely Sensed Data Informs Red List Evaluations and Conservation Priorities in Southeast Asia. 
  • Reversible protein phosphorylation regulates circadian rhythms. 
  • Rivers, blood and transportation networks. 
  • Role of TRPV ion channels in sensory transduction of osmotic stimuli in mammals. 
  • Scaling and mechanics of carnivoran footpads reveal the principles of footpad design. 
  • Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival. 
  • Selective microstimulation of central nervous system neurons. 
  • Sensitivity analysis of a model of mammalian neural membrane. 
  • Sequence coevolution and structure stabilization modulate olfactory receptor expression. 
  • Sequence heterochrony and the evolution of development. 
  • Sequences flanking the pentanucleotide T-antigen binding sites in the polyomavirus core origin help determine selectivity of DNA replication. 
  • Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins. 
  • Single origin of Malagasy Carnivora from an African ancestor. 
  • SnapShot: Mammalian Sirtuins. 
  • Social determinants of health and survival in humans and other animals. 
  • Sphingolipids--the enigmatic lipid class: biochemistry, physiology, and pathophysiology. 
  • Staying alive: cell death in antiviral immunity. 
  • Strand-specific mismatch repair in mammalian cells. 
  • Structural determinants for signal sequence function in the mammalian endoplasmic reticulum. 
  • Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus. 
  • Structures of yeast vesicle trafficking proteins. 
  • Suilloid fungi as global drivers of pine invasions. 
  • Sustaining the variety of life. 
  • TOR kinase homologs function in a signal transduction pathway that is conserved from yeast to mammals. 
  • Tapered Polymer Whiskers to Enable Three-Dimensional Tactile Feature Extraction. 
  • Tempo of trophic evolution and its impact on mammalian diversification. 
  • The Aryl Hydrocarbon Receptor: A Mediator and Potential Therapeutic Target for Ocular and Non-Ocular Neurodegenerative Diseases. 
  • The DVR gene family in embryonic development. 
  • The Marine Mammal Protection Act at 40: status, recovery, and future of U.S. marine mammals. 
  • The Signaling Pathways Project, an integrated 'omics knowledgebase for mammalian cellular signaling pathways. 
  • The TGF-beta-related DVR gene family in mammalian development. 
  • The battle of the sexes. 
  • The battle of the sexes: opposing pathways in sex determination. 
  • The consensus mechanics of cultured mammalian cells 
  • The endothelial cell protein C receptor. Cell surface expression and direct ligand binding by the soluble receptor. 
  • The genome of the green anole lizard and a comparative analysis with birds and mammals. 
  • The molecular regulation of iron metabolism. 
  • The neurobiology of innate, volitional and learned vocalizations in mammals and birds. 
  • The oral ferroportin inhibitor vamifeport improves hemodynamics in a mouse model of sickle cell disease. 
  • The origin of helping: the role of variability in reproductive potential. 
  • The perception of transparent three-dimensional objects. 
  • The role of Sry in cellular events underlying mammalian sex determination. 
  • The sea urchin embryo as a model for mammalian developmental neurotoxicity: ontogenesis of the high-affinity choline transporter and its role in cholinergic trophic activity. 
  • The shrinking ark: patterns of large mammal extinctions in India. 
  • The uses of green fluorescent protein in prokaryotes. 
  • The whisking oscillator circuit. 
  • Theme and variations: heterothermy in mammals. 
  • Total energy expenditure of bottlenose dolphins (Tursiops truncatus) of different ages. 
  • Tracheal compression delays alveolar collapse during deep diving in marine mammals. 
  • Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin. 
  • Transient transfection and purification of SARS-CoV-2 spike protein from mammalian cells. 
  • Two kinases mediate agonist-dependent phosphorylation and desensitization of the beta 2-adrenergic receptor. 
  • Type III protein secretion mechanism in mammalian and plant pathogens. 
  • Uncertainty in allometric exponent estimation: a case study in scaling metabolic rate with body mass. 
  • Uncovering the dynamics of a circadian-dopamine model influenced by the light-dark cycle 
  • Uniqueness of primate forelimb posture during quadrupedal locomotion. 
  • Update on animal models of diabetic retinopathy: from molecular approaches to mice and higher mammals. 
  • Use of protein phosphatase inhibitors. 
  • Use of recombinant adenovirus for metabolic engineering of mammalian cells. 
  • Using Cryo-EM to Map Small Ligands on Dynamic Metabolic Enzymes: Studies with Glutamate Dehydrogenase. 
  • Using noisy gene expression mediated by engineered adenovirus to probe signaling dynamics in mammalian cells. 
  • Variation in gut microbiome structure across the annual hibernation cycle in a wild primate. 
  • Visual Signals in the Mammalian Auditory System. 
  • lambda RNA internal standards quantify sensitivity and amplification efficiency of mammalian gene expression profiling. 
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  Keywords of People

  • Hirschey, Matthew, Associate Professor of Medicine, Pharmacology & Cancer Biology
  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor for Research in Molecular Biology, Cell Biology
  • Kay, Richard Frederick, Professor of Evolutionary Anthropology, Earth and Climate Sciences
  • Reddy, Timothy E, Associate Professor of Biostatistics & Bioinformatics,, Molecular Genetics and Microbiology
  • Yoder, Anne Daphne, Braxton Craven Distinguished Professor of Evolutionary Biology, Duke Science & Society