Mammary Neoplasms, Experimental

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  Subject Areas on Research

  • A comparison of tumor and normal tissue microvascular hematocrits and red cell fluxes in a rat window chamber model. 
  • A comparison using tissue electrical properties and temperature rise to determine relative absorption of microwave power in malignant tissue. 
  • A novel bioreactor for combined magnetic resonance spectroscopy and optical imaging of metabolism in 3D cell cultures. 
  • A novel method for viral gene delivery in solid tumors. 
  • A transcriptional repressor of osteopontin expression in the 4T1 murine breast cancer cell line. 
  • Absence of an effect of dietary corn oil content on plasma prolactin, progesterone, and 17 beta-estradiol in female Sprague-Dawley rats. 
  • Acceleration of mammary neoplasia in transforming growth factor alpha transgenic mice by 7,12-dimethylbenzanthracene. 
  • Active immunization using dendritic cells mixed with tumor cells inhibits the growth of primary breast cancer. 
  • Active immunotherapy with transiently transfected cytokine-secreting tumor cells inhibits breast cancer metastases in tumor-bearing animals. 
  • Adoptively transferred ex vivo expanded gammadelta-T cells mediate in vivo antitumor activity in preclinical mouse models of breast cancer. 
  • Alginate encapsulation is a highly reproducible method for tumor cell implantation in dorsal skinfold chambers. 
  • An adenoviral vaccine encoding full-length inactivated human Her2 exhibits potent immunogenicty and enhanced therapeutic efficacy without oncogenicity. 
  • Analysis of oxygen transport to tumor tissue by microvascular networks. 
  • Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors. 
  • Analysis of the heterogeneity of pO2 dynamics during photodynamic therapy with verteporfin. 
  • Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumor. 
  • Antitumor activity of creatine analogs produced by alterations in pancreatic hormones and glucose metabolism. 
  • Assessment of photosensitizer dosimetry and tissue damage assay for photodynamic therapy in advanced-stage tumors. 
  • Assessment of the protective effect of amifostine on radiation-induced pulmonary toxicity. 
  • Available space and extracellular transport of macromolecules: effects of pore size and connectedness. 
  • Bayesian semiparametric dynamic frailty models for multiple event time data. 
  • Black cohosh increases metastatic mammary cancer in transgenic mice expressing c-erbB2. 
  • Ca(2+)-dependent nitric oxide release in endothelial but not R3230Ac rat mammary adenocarcinoma cells. 
  • Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice. 
  • Chemoprevention of NMU-induced rat mammary carcinoma with the combination of melatonin and 9-cis-retinoic acid. 
  • Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents. 
  • Context-dependent effects of whole-genome duplication during mammary tumor recurrence. 
  • Cyclocreatine in cancer chemotherapy. 
  • Deep-tissue photoacoustic tomography of a genetically encoded near-infrared fluorescent probe. 
  • Delivery of chemo-sensitizing siRNAs to HER2+-breast cancer cells using RNA aptamers. 
  • Depression of murine macrophage accumulation by low-molecular-weight derived from spontaneous mammary carcinomas. 
  • Development and validation of a method for using breast core needle biopsies for gene expression microarray analyses. 
  • Development of mammary hyperplasia and neoplasia in MMTV-TGF alpha transgenic mice. 
  • Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth. 
  • Dietary fat and DMBA mammary carcinogenesis in rats. 
  • Dietary glycine inhibits angiogenesis during wound healing and tumor growth. 
  • Diminished leukocyte-endothelium interaction in tumor microvessels. 
  • Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor. 
  • Distinguishing effects on tumor multiplicity and growth rate in chemoprevention experiments. 
  • Docetaxel enhances tumor radioresponse in vivo. 
  • Effect of chemotherapy on uptake of alkali metals by experimental tumors. 
  • Effect of longitudinal oxygen gradients on effectiveness of manipulation of tumor oxygenation. 
  • Effect of mild hyperglycemia +/- meta-iodo-benzylguanidine on the radiation response of R3230 Ac tumors. 
  • Effects of bradykinin on the hemodynamics of tumor and granulating normal tissue microvasculature. 
  • Effects of diethylamine/nitric oxide on blood perfusion and oxygenation in the R3230Ac mammary carcinoma. 
  • Effects of the calcium channel blocker flunarizine on the hemodynamics and oxygenation of tumor microvasculature. 
  • Effects of the interaction between carbogen and nicotinamide on R3230 Ac tumor blood flow in Fischer 344 rats. 
  • Electric field-mediated transport of plasmid DNA in tumor interstitium in vivo. 
  • Electric fields in tumors exposed to external voltage sources: implication for electric field-mediated drug and gene delivery. 
  • Electromobility of plasmid DNA in tumor tissues during electric field-mediated gene delivery. 
  • Enhancement of cancer radiation therapy by use of adenovirus-mediated secretable glucose-regulated protein 94/gp96 expression. 
  • Evaluation of tumor microenvironment in an animal model using a nanoparticle contrast agent in computed tomography imaging. 
  • Expression of an antisense transforming growth factor-beta1 transgene reduces tumorigenicity of EMT6 mammary tumor cells. 
  • Expression of transforming growth factor beta type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells. 
  • Factors controlling oxygen utilization. 
  • Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer. 
  • Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma. 
  • Gene expression phenotypic models that predict the activity of oncogenic pathways. 
  • Genetic heterogeneity of Myc-induced mammary tumors reflecting diverse phenotypes including metastatic potential. 
  • Glutathione depletion or radiation treatment alters respiration and induces apoptosis in R3230Ac mammary carcinoma. 
  • Heat-induced gene expression as a novel targeted cancer gene therapy strategy. 
  • Heterogeneity in the hormonal responsiveness of clones derived from the 13762NF rat mammary tumor. 
  • Heterogeneity in tumor microvascular response to radiation. 
  • Human recombinant erythropoietin significantly improves tumor oxygenation independent of its effects on hemoglobin. 
  • Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development. 
  • Imaging nanoprobe for prediction of outcome of nanoparticle chemotherapy by using mammography. 
  • Immunologic control of the ascites form of murine adenocarcinoma 755. II. Tumor immunity associated with a Friend--Moloney--Ra,scher-type virus. 
  • Immunologic control of the ascites of murine adenocarcinoma 755. I. Protection with syngeneic immune serum or lymphoid cells. 
  • Immunotherapy with vaccines combining MHC class II/CD80+ tumor cells with interleukin-12 reduces established metastatic disease and stimulates immune effectors and monokine induced by interferon gamma. 
  • In vivo expansion, persistence, and function of peptide vaccine-induced CD8 T cells occur independently of CD4 T cells. 
  • Inhibition of Neu-induced mammary carcinogenesis in transgenic mice expressing ERΔ3, a dominant negative estrogen receptor α variant. 
  • Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth. 
  • Initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent models. 
  • Initiation of metastatic breast carcinoma by targeting of the ductal epithelium with adenovirus-cre: a novel transgenic mouse model of breast cancer. 
  • Insulin in aging and cancer: antidiabetic drug Diabenol as geroprotector and anticarcinogen. 
  • Interferon gamma (IFNgamma) gene transfer of an EMT6 tumor that is poorly responsive to IFNgamma stimulation: increase in tumor immunogenicity is accompanied by induction of a mouse class II transactivator and class II MHC. 
  • In Vivo Effects of Long-Term Cigarette Smoke Exposure on Mammary Tissue in Mice. 
  • Lack of effects from 2000-Hz magnetic fields on mammary adenocarcinoma and reproductive hormones in rats 
  • Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy. 
  • Local 42 degrees C hyperthermia improves vascular conductance of the R3230Ac rat mammary adenocarcinoma during sodium nitroprusside infusion. 
  • MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression. 
  • Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells. 
  • Mammary carcinogenesis in rats fed different amounts and types of fat. 
  • Mathematical modeling of the Phoenix Rising pathway. 
  • Melatonin synergizes with retinoic acid in the prevention and regression of breast cancer. 
  • Metastatic human breast cancer to the spine produces mechanical hyperalgesia and gait deficits in rodents. 
  • Microdosimetric analysis of alpha-particle-emitting targeted radiotherapeutics using histological images. 
  • Microwave hyperthermia and its effect on tumor blood flow in rats. 
  • Microwave power absorption differences between normal and malignant tissue. 
  • Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis. 
  • Modulation of murine breast tumor vascularity, hypoxia and chemotherapeutic response by exercise. 
  • Monitoring metabolite gradients in the blood, liver, and tumor after induced hyperglycemia in rats with R3230 flank tumors using microdialysis and bioluminescence imaging. 
  • Morphologic and hemodynamic comparison of tumor and healing normal tissue microvasculature. 
  • Multifunctional nanocarriers for mammographic quantification of tumor dosing and prognosis of breast cancer therapy. 
  • Murine malignant cells synthesize a 19,000-dalton protein that is physicochemically and antigenically related to the immunosuppressive retroviral protein, P15E. 
  • Nanoparticle Encapsulation of Synergistic Immune Agonists Enables Systemic Codelivery to Tumor Sites and IFNβ-Driven Antitumor Immunity. 
  • Nanoparticle formulation improves doxorubicin efficacy by enhancing host antitumor immunity. 
  • Nitric oxide synthase inhibition irreversibly decreases perfusion in the R3230Ac rat mammary adenocarcinoma. 
  • Number of pregnancies and ovariectomy modify mammary carcinoma development in transgenic HER-2/neu female mice. 
  • Observation of incipient tumor angiogenesis that is independent of hypoxia and hypoxia inducible factor-1 activation. 
  • Optical imaging of tumor hypoxia dynamics. 
  • Osteopontin regulates ubiquitin-dependent degradation of Stat1 in murine mammary epithelial tumor cells. 
  • Oxygen distributions within R3230Ac tumors growing in dorsal flap window chambers in rats. 
  • Quantitative diffuse reflectance and fluorescence spectroscopy: tool to monitor tumor physiology in vivo. 
  • Quantitative mapping of hemodynamics in the lung, brain, and dorsal window chamber-grown tumors using a novel, automated algorithm. 
  • RNA-binding proteins to assess gene expression states of co-cultivated cells in response to tumor cells. 
  • Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. 
  • Radiation induces aerobic glycolysis through reactive oxygen species. 
  • Radioiodinated B6.2 monoclonal antibody: further characterization of a potential radiopharmaceutical for the identification of breast tumors. 
  • Regression of NMU-induced mammary tumors with the combination of melatonin and 9-cis-retinoic acid. 
  • SPSB1 promotes breast cancer recurrence by potentiating c-MET signaling. 
  • Signatures associated with rejection or recurrence in HER-2/neu-positive mammary tumors. 
  • Simultaneous acquisition of multiple orders of intermolecular multiple-quantum coherence images in vivo. 
  • Simultaneous in vivo optical quantification of key metabolic and vascular endpoints reveals tumor metabolic diversity in murine breast tumor models. 
  • Simultaneous measurement of liposome extravasation and content release in tumors. 
  • Spatial heterogeneity and oxygen dependence of glucose consumption in R3230Ac and fibrosarcomas of the Fischer 344 rat. 
  • Spectral imaging facilitates visualization and measurements of unstable and abnormal microvascular oxygen transport in tumors. 
  • Stereocomplexed poly(lactic acid)-poly(ethylene glycol) nanoparticles with dual-emissive boron dyes for tumor accumulation. 
  • Stimulation of Oncogene-Specific Tumor-Infiltrating T Cells through Combined Vaccine and αPD-1 Enable Sustained Antitumor Responses against Established HER2 Breast Cancer. 
  • Stressors and antistressors: how do they influence life span in HER-2/neu transgenic mice? 
  • Stroma-free human hemoglobin A decreases R3230Ac rat mammary adenocarcinoma blood flow and oxygen partial pressure. 
  • Technology evaluation: Theratope, Biomira Inc. 
  • The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer. 
  • The effect of melatonin treatment regimen on mammary adenocarcinoma development in HER-2/neu transgenic mice. 
  • The effect of rate of heating or cooling prior to heating on tumor and normal tissue microcirculatory blood flow. 
  • The mechanisms by which hyperbaric oxygen and carbogen improve tumour oxygenation. 
  • The novel tubulin-binding drug BTO-956 inhibits R3230AC mammary carcinoma growth and angiogenesis in Fischer 344 rats. 
  • The pervasive presence of fluctuating oxygenation in tumors. 
  • The selective estrogen receptor modulator arzoxifene and the rexinoid LG100268 cooperate to promote transforming growth factor beta-dependent apoptosis in breast cancer. 
  • Theoretical simulation of oxygen transport to tumors by three-dimensional networks of microvessels. 
  • Thrombin-cleaved COOH(-) terminal osteopontin peptide binds with cyclophilin C to CD147 in murine breast cancer cells. 
  • Time-resolved optical tomography using short-pulse laser for tumor detection. 
  • Tissue gradients of energy metabolites mirror oxygen tension gradients in a rat mammary carcinoma model. 
  • Tissue transglutaminase is expressed as a host response to tumor invasion and inhibits tumor growth. 
  • Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant. 
  • Treating triple-negative breast cancer by a combination of rapamycin and cyclophosphamide: an in vivo bioluminescence imaging study. 
  • Tumor Endothelial Cells with Distinct Patterns of TGFβ-Driven Endothelial-to-Mesenchymal Transition. 
  • Tumor cells upregulate normoxic HIF-1α in response to doxorubicin. 
  • Tumor immunotherapy targeting fibroblast activation protein, a product expressed in tumor-associated fibroblasts. 
  • Tumor prevention by 9-cis-retinoic acid in the N-nitroso-N-methylurea model of mammary carcinogenesis is potentiated by the pineal hormone melatonin. 
  • Tumor-targeted IL-12 combined with tumor resection yields a survival-favorable immune profile. 
  • Type III TGF-β receptor downregulation generates an immunotolerant tumor microenvironment. 
  • Urea as a recovery marker for quantitative assessment of tumor interstitial solutes with microdialysis. 
  • Using optical spectroscopy to longitudinally monitor physiological changes within solid tumors. 
  • XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A. 
  • [Inhibitation of tumor angiogenesis, growth and metastasis by blocking VEGF paracrine pathway]. 
  • [Using Hsp70 promoter to regulate target gene expression in tumor]. 
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  Keywords of People

  • Badea, Cristian Tudorel, Professor in Radiology, Biomedical Engineering
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Cianciolo, George James, Associate Professor Emeritus of Pathology, Pathology
  • Hanks, Brent A., Associate Professor of Medicine, Pharmacology & Cancer Biology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Palmer, Gregory M., Associate Professor of Radiation Oncology, Radiation Oncology