Manganese

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  Subject Areas on Research

  • 1,2-Diacylglycerol choline phosphotransferase catalyzes the final step in the unique Treponema denticola phosphatidylcholine biosynthesis pathway. 
  • 31P NMR probes of chemical dynamics: paramagnetic relaxation enhancement of the (1)H and (31)P NMR resonances of methyl phosphite and methylethyl phosphate anions by selected metal complexes. 
  • De Novo Design, Solution Characterization, and Crystallographic Structure of an Abiological Mn-Porphyrin-Binding Protein Capable of Stabilizing a Mn(V) Species. 
  • A KINETIC INVESTIGATION OF THE INTERACTION OF ADENOSINE-5'-TRIPHOSPHATE WITH DIVALENT METAL IONS. 
  • A calcium-activated, nonselective cationic conductance in Aplysia silent neurons. 
  • A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. 
  • A manganese porphyrin suppresses oxidative stress and extends the life span of streptozotocin-diabetic rats. 
  • A method to convert MRI images of temperature change into images of absolute temperature in solid tumours. 
  • A proton and phosphorus nuclear magnetic resonance study of ternary complexes of cyclic adenosine 3':5'-monophosphate, adenosine 5'-triphosphate, and Mn2+. 
  • Adolescent nicotine exposure alters cardiac autonomic responsiveness: beta-adrenergic and m2-muscarinic receptors and their linkage to adenylyl cyclase. 
  • Agonist-induced sensitization of beta-adrenoceptor signaling in neonatal rat heart: expression and catalytic activity of adenylyl cyclase. 
  • Alterations in human trabecular meshwork cell homeostasis by selenium. 
  • Altered cyclic AMP-dependent human chorionic gonadotropin production in cultured human placental trophoblasts exposed to ethanol. 
  • An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins--From superoxide dismutation to H2O2-driven pathways. 
  • Assessment of inorganic contamination of private wells and demonstration of effective filter-based reduction: A pilot-study in Stokes County, North Carolina. 
  • Assessment of metals in cosmetics commonly used in Saudi Arabia. 
  • Autoreceptor presynaptic control of dopamine release from striatum is lost at early stages of manganese poisoning. 
  • Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site. 
  • Blood levels of trace metals and amyotrophic lateral sclerosis. 
  • Challenges encountered during development of Mn porphyrin-based, potent redox-active drug and superoxide dismutase mimic, MnTnBuOE-2-PyP5+, and its alkoxyalkyl analogues. 
  • Changes in streptonigrin lethality during adaptation of Escherichia coli to picolinic acid. Correlation with intracellular picolinate and iron uptake. 
  • Characterization and structure of the manganese-responsive transcriptional regulator ScaR. 
  • Characterization of Mn(III) complexes of linear and cyclic desferrioxamines as mimics of superoxide dismutase activity. 
  • Characterization of the DNA- and metal-binding properties of Vibrio anguillarum fur reveals conservation of a structural Zn(2+) ion. 
  • Chiral polyoxometalate-induced enantiomerically 3D architectures: a new route for synthesis of high-dimensional chiral compounds. 
  • Complementation of SOD-deficient Escherichia coli by manganese porphyrin mimics of superoxide dismutase activity. 
  • Conversion of protein phosphatase 1 catalytic subunit to a Mn(2+)-dependent enzyme impairs its regulation by inhibitor 1. 
  • Cooperative interaction of divalent metal ions, substrate, and tissue factor with factor VIIa. 
  • Corrosion behavior of Au and Ag modified Cu-Ni-Mn alloys. 
  • Crystal structure of activated CheY. Comparison with other activated receiver domains. 
  • Cytochemical detection of superoxide in cerebral inflammation and ischemia in vivo. 
  • DNA repair protein O6-alkylguanine-DNA alkyltransferase is phosphorylated by two distinct and novel protein kinases in human brain tumour cells. 
  • Design and synthesis of manganese porphyrins with tailored lipophilicity: investigation of redox properties and superoxide dismutase activity. 
  • Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities. 
  • Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators. 
  • Detailed mechanism of the autoxidation of N-hydroxyurea catalyzed by a superoxide dismutase mimic Mn(III) porphyrin: formation of the nitrosylated Mn(II) porphyrin as an intermediate. 
  • Determination of high density lipoprotein-cholesterol in stored human plasma. 
  • Determination of residual manganese in Mn porphyrin-based superoxide dismutase (SOD) and peroxynitrite reductase mimics. 
  • Differential coordination demands in Fe versus Mn water-soluble cationic metalloporphyrins translate into remarkably different aqueous redox chemistry and biology. 
  • Divalent cation activation of galactosyltransferase in native mammary Golgi vesicles. 
  • Duplication of single stranded DNA catalyzed by calf thymus DNA polymerase alpha. 
  • ELEMENTARY STEPS IN ENZYME REACTIONS (AS STUDIED BY RELAXATION SPECTROMETRY). 
  • Early estrogen action: nuclear synthesis and accumulation of protein correlated with enhancement of two DNA-dependent RNA polymerase activities. 
  • Effect of lipophilicity of Mn (III) ortho N-alkylpyridyl- and diortho N, N'-diethylimidazolylporphyrins in two in-vitro models of oxygen and glucose deprivation-induced neuronal death. 
  • Effects of Manganese Porphyrins on Cellular Sulfur Metabolism. 
  • Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model. 
  • Effects of metalloporphyrin catalytic antioxidants in experimental brain ischemia. 
  • Electrostatic contribution in the catalysis of O2*- dismutation by superoxide dismutase mimics. MnIIITE-2-PyP5+ versus MnIIIBr8T-2-PyP+. 
  • Evaluation of the compounds commonly known as superoxide dismutase and catalase mimics in cellular models. 
  • Flavin-dependent antioxidant properties of a new series of meso-N,N'-dialkyl-imidazolium substituted manganese(III) porphyrins. 
  • Four-decade responses of soil trace elements to an aggrading old-field forest: B, Mn, Zn, Cu, and Fe. 
  • Functional neuroimaging using ultrasonic blood-brain barrier disruption and manganese-enhanced MRI. 
  • Glucocorticoid-targeting of the adenylyl cyclase signaling pathway in the cerebellum of young vs. aged rats. 
  • H2O2-Driven Anticancer Activity of Mn Porphyrins and the Underlying Molecular Pathways. 
  • High lipophilicity of meta Mn(III) N-alkylpyridylporphyrin-based superoxide dismutase mimics compensates for their lower antioxidant potency and makes them as effective as ortho analogues in protecting superoxide dismutase-deficient Escherichia coli. 
  • Imidazole rescue of a cytosine mutation in a self-cleaving ribozyme. 
  • Impact of electrostatics in redox modulation of oxidative stress by Mn porphyrins: protection of SOD-deficient Escherichia coli via alternative mechanism where Mn porphyrin acts as a Mn carrier. 
  • Increased survival of skin flaps by scavengers of superoxide radical. 
  • Investigation of copper-manganese-nickel alloys for dental purposes. 
  • Manganese Porphyrin and Radiotherapy Improves Local Tumor Response and Overall Survival in Orthotopic Murine Mammary Carcinoma Models. 
  • Manganese balance and clinical observations in young men fed a manganese-deficient diet. 
  • Manganese poisoning reduces strychnine-insensitive glycine binding sites in the globus pallidus of the mouse brain. 
  • Manganese porphyrins and related compounds as mimics of superoxide dismutase. 
  • Manganese superoxide dismutases from Escherichia coli and from yeast mitochondria: preliminary x-ray crystallographic studies. 
  • Manganese(III) biliverdin IX dimethyl ester: a powerful catalytic scavenger of superoxide employing the Mn(III)/Mn(IV) redox couple. 
  • Manganese-porphyrin reactions with lipids and lipoproteins. 
  • Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweight. 
  • Metabolic balance of manganese in young men consuming diets containing five levels of dietary manganese. 
  • Metalloporphyrins are potent inhibitors of lipid peroxidation. 
  • Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N-methoxyalkylpyridylporphyrins. 
  • Mn Porphyrin-Based Redox-Active Drugs: Differential Effects as Cancer Therapeutics and Protectors of Normal Tissue Against Oxidative Injury. 
  • Mn porphyrin-based SOD mimic, MnTnHex-2-PyP(5+), and non-SOD mimic, MnTBAP(3-), suppressed rat spinal cord ischemia/reperfusion injury via NF-κB pathways. 
  • Mn porphyrin-based superoxide dismutase (SOD) mimic, MnIIITE-2-PyP5+, targets mouse heart mitochondria. 
  • Mn porphyrins as novel molecular magnetic resonance imaging contrast agents. 
  • Myocardial guanylate cyclase: properties of the enzyme and effects of cholinergic agonists in vitro. 
  • NMDA receptor-mediated depolarizing action of proline on CA1 pyramidal cells. 
  • New PEG-ylated Mn(III) porphyrins approaching catalytic activity of SOD enzyme. 
  • New class of potent catalysts of O2.-dismutation. Mn(III) ortho-methoxyethylpyridyl- and di-ortho-methoxyethylimidazolylporphyrins. 
  • Nuclear magnetic resonance study of ligand binding to Mn-aspartate transcarbamylase. 
  • Ontogeny of regulatory mechanisms for beta-adrenoceptor control of rat cardiac adenylyl cyclase: targeting of G-proteins and the cyclase catalytic subunit. 
  • Oxalate decarboxylase uses electron hole hopping for catalysis. 
  • Paraparesis, hypermanganesaemia, and polycythaemia: a novel presentation of cirrhosis. 
  • Pathology of inherited manganese transporter deficiency. 
  • Peroxynitrite flux-mediated LDL oxidation is inhibited by manganese porphyrins in the presence of uric acid. 
  • Peroxynitrite formation in nitric oxide-exposed submitochondrial particles: detection, oxidative damage and catalytic removal by Mn-porphyrins. 
  • Phenotypic dissections of the Blastocladiella emersonii zoospore's developmental choice. 
  • Pigment formation from L-tryptophan by a particulate fraction from an Achromobacter species. 
  • Plasma uptake of manganese as affected by oral loads of manganese, calcium, milk, phosphorus, copper, and zinc. 
  • Preferential uncoupling by manganese of alpha adrenergic receptor mediated inhibition of adenylate cyclase in human platelets. 
  • Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast. 
  • Protein phosphatase 2A inhibitors, I(1)(PP2A) and I(2)(PP2A), associate with and modify the substrate specificity of protein phosphatase 1. 
  • Purification and characterization of the beta-adrenergic receptor kinase. 
  • RNA polymerase B from Drosophila melanogaster larvae. Purification and partial characterization. 
  • Radiation-Mediated Tumor Growth Inhibition Is Significantly Enhanced with Redox-Active Compounds That Cycle with Ascorbate. 
  • Rational design of superoxide dismutase (SOD) mimics: the evaluation of the therapeutic potential of new cationic Mn porphyrins with linear and cyclic substituents. 
  • Reactions of manganese porphyrins with peroxynitrite and carbonate radical anion. 
  • Recombinants within the tyrosine kinase region of v-abl and v-src identify a v-abl segment that confers lymphoid specificity. 
  • Redox modulation of oxidative stress by Mn porphyrin-based therapeutics: the effect of charge distribution. 
  • Redox potential determines the reaction mechanism of HNO donors with Mn and Fe porphyrins: defining the better traps. 
  • Relaxation spectra of adenosine triphosphate-creatine phosphotransferase. 
  • Relaxation spectra of pyruvate kinase. 
  • Role of calcium in monitor peptide-stimulated cholecystokinin release from perifused intestinal cells. 
  • SK&F 96365, a novel inhibitor of receptor-mediated calcium entry. 
  • Seizure activity in vitro: a dual focus model. 
  • Sensitization of frog erythrocyte adenylate cyclase system by tumor-promoting phorbol diesters. 
  • Serotonergic cell signaling in an animal model of aging and depression: olfactory bulbectomy elicits different adaptations in brain regions of young adult vs aging rats. 
  • Solving the problem at the source: controlling Mn release at the sediment-water interface via hypolimnetic oxygenation 
  • Strong Binding of Platelet Integrin αIIbβ3 to Fibrin Clots: Potential Target to Destabilize Thrombi. 
  • Structural basis for the metal-selective activation of the manganese transport regulator of Bacillus subtilis. 
  • Structure of the manganese-bound manganese transport regulator of Bacillus subtilis. 
  • Superoxide dismutase from Streptococcus mutans. Isolation and characterization of two forms of the enzyme. 
  • Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential. 
  • Syndrome of hepatic cirrhosis, dystonia, polycythemia, and hypermanganesemia caused by mutations in SLC30A10, a manganese transporter in man. 
  • The UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis utilizes Mn2+ cluster for catalysis. 
  • The conformations of the manganese transport regulator of Bacillus subtilis in its metal-free state. 
  • The ortho effect makes manganese(III) meso-tetrakis(N-methylpyridinium-2-yl)porphyrin a powerful and potentially useful superoxide dismutase mimic. 
  • The role of calcium in the regulation of prostacyclin synthesis by porcine aortic endothelial cells. 
  • The structure and function of pyruvate kinase. 
  • The vibrio cholerae hybrid sensor kinase VieS contributes to motility and biofilm regulation by altering the cyclic diguanylate level. 
  • Thiol regulation by Mn porphyrins, commonly known as SOD mimics. 
  • Transition metal-chelate complexes as relaxation modifiers in nuclear magnetic resonance. 
  • Ultrasonic disruption of the blood-brain barrier enables in vivo functional mapping of the mouse barrel field cortex with manganese-enhanced MRI. 
  • Unique uncoupling of the frog erythrocyte adenylate cyclase system by manganese. Loss of hormone and guanine nucleotide-sensitive enzyme activities without loss of nucleotide-sensitive, high affinity agonist binding. 
  • Use of phosphorus ligand NMR probes to investigate electronic and second-sphere solvent effects in ligand substitution reactions at manganese(II) and manganese(III). 
  • Vanadium, aluminum, magnesium and manganese are not elevated in hair samples in amyotrophic lateral sclerosis. 
  • Water exchange rates of water-soluble manganese(III) porphyrins of therapeutical potential. 
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  Keywords of People

  • Gunn, Michael Dee, Professor of Medicine, Immunology
  • Johnson, G. Allan, Charles E. Putman University Distinguished Professor of Radiology, Biomedical Engineering
  • Richter, Daniel D., Professor in the Division of Earth and Climate Science, Environmental Sciences and Policy