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Subject Areas on Research
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1,2-Diacylglycerol choline phosphotransferase catalyzes the final step in the unique Treponema denticola phosphatidylcholine biosynthesis pathway.
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31P NMR probes of chemical dynamics: paramagnetic relaxation enhancement of the (1)H and (31)P NMR resonances of methyl phosphite and methylethyl phosphate anions by selected metal complexes.
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De Novo
Design, Solution Characterization, and Crystallographic Structure of an Abiological Mn-Porphyrin-Binding Protein Capable of Stabilizing a Mn(V) Species.
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A KINETIC INVESTIGATION OF THE INTERACTION OF ADENOSINE-5'-TRIPHOSPHATE WITH DIVALENT METAL IONS.
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A calcium-activated, nonselective cationic conductance in Aplysia silent neurons.
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A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes.
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A manganese porphyrin suppresses oxidative stress and extends the life span of streptozotocin-diabetic rats.
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A method to convert MRI images of temperature change into images of absolute temperature in solid tumours.
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A proton and phosphorus nuclear magnetic resonance study of ternary complexes of cyclic adenosine 3':5'-monophosphate, adenosine 5'-triphosphate, and Mn2+.
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Adolescent nicotine exposure alters cardiac autonomic responsiveness: beta-adrenergic and m2-muscarinic receptors and their linkage to adenylyl cyclase.
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Agonist-induced sensitization of beta-adrenoceptor signaling in neonatal rat heart: expression and catalytic activity of adenylyl cyclase.
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Alterations in human trabecular meshwork cell homeostasis by selenium.
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Altered cyclic AMP-dependent human chorionic gonadotropin production in cultured human placental trophoblasts exposed to ethanol.
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An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins--From superoxide dismutation to H2O2-driven pathways.
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Assessment of inorganic contamination of private wells and demonstration of effective filter-based reduction: A pilot-study in Stokes County, North Carolina.
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Assessment of metals in cosmetics commonly used in Saudi Arabia.
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Autoreceptor presynaptic control of dopamine release from striatum is lost at early stages of manganese poisoning.
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Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site.
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Blood levels of trace metals and amyotrophic lateral sclerosis.
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Challenges encountered during development of Mn porphyrin-based, potent redox-active drug and superoxide dismutase mimic, MnTnBuOE-2-PyP5+, and its alkoxyalkyl analogues.
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Changes in streptonigrin lethality during adaptation of Escherichia coli to picolinic acid. Correlation with intracellular picolinate and iron uptake.
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Characterization and structure of the manganese-responsive transcriptional regulator ScaR.
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Characterization of Mn(III) complexes of linear and cyclic desferrioxamines as mimics of superoxide dismutase activity.
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Characterization of the DNA- and metal-binding properties of Vibrio anguillarum fur reveals conservation of a structural Zn(2+) ion.
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Chiral polyoxometalate-induced enantiomerically 3D architectures: a new route for synthesis of high-dimensional chiral compounds.
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Complementation of SOD-deficient Escherichia coli by manganese porphyrin mimics of superoxide dismutase activity.
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Conversion of protein phosphatase 1 catalytic subunit to a Mn(2+)-dependent enzyme impairs its regulation by inhibitor 1.
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Cooperative interaction of divalent metal ions, substrate, and tissue factor with factor VIIa.
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Corrosion behavior of Au and Ag modified Cu-Ni-Mn alloys.
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Crystal structure of activated CheY. Comparison with other activated receiver domains.
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Cytochemical detection of superoxide in cerebral inflammation and ischemia in vivo.
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DNA repair protein O6-alkylguanine-DNA alkyltransferase is phosphorylated by two distinct and novel protein kinases in human brain tumour cells.
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Design and synthesis of manganese porphyrins with tailored lipophilicity: investigation of redox properties and superoxide dismutase activity.
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Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities.
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Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators.
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Detailed mechanism of the autoxidation of N-hydroxyurea catalyzed by a superoxide dismutase mimic Mn(III) porphyrin: formation of the nitrosylated Mn(II) porphyrin as an intermediate.
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Determination of high density lipoprotein-cholesterol in stored human plasma.
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Determination of residual manganese in Mn porphyrin-based superoxide dismutase (SOD) and peroxynitrite reductase mimics.
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Differential coordination demands in Fe versus Mn water-soluble cationic metalloporphyrins translate into remarkably different aqueous redox chemistry and biology.
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Divalent cation activation of galactosyltransferase in native mammary Golgi vesicles.
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Duplication of single stranded DNA catalyzed by calf thymus DNA polymerase alpha.
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ELEMENTARY STEPS IN ENZYME REACTIONS (AS STUDIED BY RELAXATION SPECTROMETRY).
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Early estrogen action: nuclear synthesis and accumulation of protein correlated with enhancement of two DNA-dependent RNA polymerase activities.
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Effect of lipophilicity of Mn (III) ortho N-alkylpyridyl- and diortho N, N'-diethylimidazolylporphyrins in two in-vitro models of oxygen and glucose deprivation-induced neuronal death.
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Effects of Manganese Porphyrins on Cellular Sulfur Metabolism.
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Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model.
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Effects of metalloporphyrin catalytic antioxidants in experimental brain ischemia.
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Electrostatic contribution in the catalysis of O2*- dismutation by superoxide dismutase mimics. MnIIITE-2-PyP5+ versus MnIIIBr8T-2-PyP+.
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Evaluation of the compounds commonly known as superoxide dismutase and catalase mimics in cellular models.
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Flavin-dependent antioxidant properties of a new series of meso-N,N'-dialkyl-imidazolium substituted manganese(III) porphyrins.
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Four-decade responses of soil trace elements to an aggrading old-field forest: B, Mn, Zn, Cu, and Fe.
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Functional neuroimaging using ultrasonic blood-brain barrier disruption and manganese-enhanced MRI.
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Glucocorticoid-targeting of the adenylyl cyclase signaling pathway in the cerebellum of young vs. aged rats.
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H2O2-Driven Anticancer Activity of Mn Porphyrins and the Underlying Molecular Pathways.
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High lipophilicity of meta Mn(III) N-alkylpyridylporphyrin-based superoxide dismutase mimics compensates for their lower antioxidant potency and makes them as effective as ortho analogues in protecting superoxide dismutase-deficient Escherichia coli.
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Imidazole rescue of a cytosine mutation in a self-cleaving ribozyme.
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Impact of electrostatics in redox modulation of oxidative stress by Mn porphyrins: protection of SOD-deficient Escherichia coli via alternative mechanism where Mn porphyrin acts as a Mn carrier.
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Increased survival of skin flaps by scavengers of superoxide radical.
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Investigation of copper-manganese-nickel alloys for dental purposes.
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Manganese Porphyrin and Radiotherapy Improves Local Tumor Response and Overall Survival in Orthotopic Murine Mammary Carcinoma Models.
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Manganese balance and clinical observations in young men fed a manganese-deficient diet.
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Manganese poisoning reduces strychnine-insensitive glycine binding sites in the globus pallidus of the mouse brain.
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Manganese porphyrins and related compounds as mimics of superoxide dismutase.
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Manganese superoxide dismutases from Escherichia coli and from yeast mitochondria: preliminary x-ray crystallographic studies.
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Manganese(III) biliverdin IX dimethyl ester: a powerful catalytic scavenger of superoxide employing the Mn(III)/Mn(IV) redox couple.
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Manganese-porphyrin reactions with lipids and lipoproteins.
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Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweight.
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Metabolic balance of manganese in young men consuming diets containing five levels of dietary manganese.
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Metalloporphyrins are potent inhibitors of lipid peroxidation.
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Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N-methoxyalkylpyridylporphyrins.
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Mn Porphyrin-Based Redox-Active Drugs: Differential Effects as Cancer Therapeutics and Protectors of Normal Tissue Against Oxidative Injury.
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Mn porphyrin-based SOD mimic, MnTnHex-2-PyP(5+), and non-SOD mimic, MnTBAP(3-), suppressed rat spinal cord ischemia/reperfusion injury via NF-κB pathways.
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Mn porphyrin-based superoxide dismutase (SOD) mimic, MnIIITE-2-PyP5+, targets mouse heart mitochondria.
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Mn porphyrins as novel molecular magnetic resonance imaging contrast agents.
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Myocardial guanylate cyclase: properties of the enzyme and effects of cholinergic agonists in vitro.
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NMDA receptor-mediated depolarizing action of proline on CA1 pyramidal cells.
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Neurotoxicity of manganese chloride in neonatal and adult CD rats following subchronic (21-day) high-dose oral exposure.
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New PEG-ylated Mn(III) porphyrins approaching catalytic activity of SOD enzyme.
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New class of potent catalysts of O2.-dismutation. Mn(III) ortho-methoxyethylpyridyl- and di-ortho-methoxyethylimidazolylporphyrins.
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Nuclear magnetic resonance study of ligand binding to Mn-aspartate transcarbamylase.
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Ontogeny of regulatory mechanisms for beta-adrenoceptor control of rat cardiac adenylyl cyclase: targeting of G-proteins and the cyclase catalytic subunit.
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Oxalate decarboxylase uses electron hole hopping for catalysis.
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Paraparesis, hypermanganesaemia, and polycythaemia: a novel presentation of cirrhosis.
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Pathology of inherited manganese transporter deficiency.
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Peroxynitrite flux-mediated LDL oxidation is inhibited by manganese porphyrins in the presence of uric acid.
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Peroxynitrite formation in nitric oxide-exposed submitochondrial particles: detection, oxidative damage and catalytic removal by Mn-porphyrins.
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Phenotypic dissections of the Blastocladiella emersonii zoospore's developmental choice.
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Pigment formation from L-tryptophan by a particulate fraction from an Achromobacter species.
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Plasma uptake of manganese as affected by oral loads of manganese, calcium, milk, phosphorus, copper, and zinc.
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Potential impacts of leakage from deep CO2 geosequestration on overlying freshwater aquifers.
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Preferential uncoupling by manganese of alpha adrenergic receptor mediated inhibition of adenylate cyclase in human platelets.
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Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast.
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Protein phosphatase 2A inhibitors, I(1)(PP2A) and I(2)(PP2A), associate with and modify the substrate specificity of protein phosphatase 1.
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Purification and characterization of the beta-adrenergic receptor kinase.
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RNA polymerase B from Drosophila melanogaster larvae. Purification and partial characterization.
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Radiation-Mediated Tumor Growth Inhibition Is Significantly Enhanced with Redox-Active Compounds That Cycle with Ascorbate.
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Rapid (<3 min) microwave synthesis of block copolymer templated ordered mesoporous metal oxide and carbonate films using nitrate-citric acid systems.
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Rational design of superoxide dismutase (SOD) mimics: the evaluation of the therapeutic potential of new cationic Mn porphyrins with linear and cyclic substituents.
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Reactions of manganese porphyrins with peroxynitrite and carbonate radical anion.
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Recombinants within the tyrosine kinase region of v-abl and v-src identify a v-abl segment that confers lymphoid specificity.
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Redox modulation of oxidative stress by Mn porphyrin-based therapeutics: the effect of charge distribution.
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Redox potential determines the reaction mechanism of HNO donors with Mn and Fe porphyrins: defining the better traps.
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Relaxation spectra of adenosine triphosphate-creatine phosphotransferase.
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Relaxation spectra of pyruvate kinase.
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Role of calcium in monitor peptide-stimulated cholecystokinin release from perifused intestinal cells.
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SK&F 96365, a novel inhibitor of receptor-mediated calcium entry.
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Seizure activity in vitro: a dual focus model.
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Sensitization of frog erythrocyte adenylate cyclase system by tumor-promoting phorbol diesters.
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Serotonergic cell signaling in an animal model of aging and depression: olfactory bulbectomy elicits different adaptations in brain regions of young adult vs aging rats.
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Solving the problem at the source: controlling Mn release at the sediment-water interface via hypolimnetic oxygenation
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Strong Binding of Platelet Integrin αIIbβ3 to Fibrin Clots: Potential Target to Destabilize Thrombi.
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Structural basis for the metal-selective activation of the manganese transport regulator of Bacillus subtilis.
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Structure of the manganese-bound manganese transport regulator of Bacillus subtilis.
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Superoxide dismutase from Streptococcus mutans. Isolation and characterization of two forms of the enzyme.
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Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential.
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Syndrome of hepatic cirrhosis, dystonia, polycythemia, and hypermanganesemia caused by mutations in SLC30A10, a manganese transporter in man.
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The UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis utilizes Mn2+ cluster for catalysis.
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The conformations of the manganese transport regulator of Bacillus subtilis in its metal-free state.
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The ortho effect makes manganese(III) meso-tetrakis(N-methylpyridinium-2-yl)porphyrin a powerful and potentially useful superoxide dismutase mimic.
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The role of calcium in the regulation of prostacyclin synthesis by porcine aortic endothelial cells.
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The structure and function of pyruvate kinase.
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The vibrio cholerae hybrid sensor kinase VieS contributes to motility and biofilm regulation by altering the cyclic diguanylate level.
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Thiol regulation by Mn porphyrins, commonly known as SOD mimics.
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Transition metal-chelate complexes as relaxation modifiers in nuclear magnetic resonance.
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Ultrasonic disruption of the blood-brain barrier enables in vivo functional mapping of the mouse barrel field cortex with manganese-enhanced MRI.
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Unique uncoupling of the frog erythrocyte adenylate cyclase system by manganese. Loss of hormone and guanine nucleotide-sensitive enzyme activities without loss of nucleotide-sensitive, high affinity agonist binding.
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Use of phosphorus ligand NMR probes to investigate electronic and second-sphere solvent effects in ligand substitution reactions at manganese(II) and manganese(III).
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Vanadium, aluminum, magnesium and manganese are not elevated in hair samples in amyotrophic lateral sclerosis.
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Water exchange rates of water-soluble manganese(III) porphyrins of therapeutical potential.
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Keywords of People