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Subject Areas on Research
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A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues.
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A humanized mouse model to study mast cells mediated cutaneous adverse drug reactions.
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A new cardiac MASTer switch for the renin-angiotensin system.
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A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer.
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A role for CD21/CD35 and CD19 in responses to acute septic peritonitis: a potential mechanism for mast cell activation.
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Aggressive topical corticosteroid therapy: a novel approach to mast-cell-dependent cutaneous disorders.
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Alopecia in IL-10-deficient mouse pups is c-kit-dependent and can be triggered by iron deficiency.
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An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response.
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Analysis of TRPV channel activation by stimulation of FCεRI and MRGPR receptors in mouse peritoneal mast cells.
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Autoimmune Theories of Chronic Spontaneous Urticaria.
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Avoiding Cardiovascular Collapse: Pediatric Cutaneous Mastocytosis and Anesthetic Challenges.
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Bacteria-host cell interaction mediated by cellular cholesterol/glycolipid-enriched microdomains.
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Biomarkers in the diagnosis of anaphylaxis: making nature disclose her mysteries.
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Bombesin-like peptides and mast cell responses: relevance to bronchopulmonary dysplasia?
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Characterization of bone marrow mast cells in acute myeloid leukemia with t(8;21) (q22;q22); RUNX1-RUNX1T1.
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Chemokine production by G protein-coupled receptor activation in a human mast cell line: roles of extracellular signal-regulated kinase and NFAT.
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Chemokines have diverse abilities to form solid phase gradients.
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Clinical implications of mast cell-bacteria interaction.
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Cloning of the mast cell protease, RMCP II. Evidence for cell-specific expression and a multi-gene family.
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Contribution of IL-13 to early exocrinopathy in Id3-/- mice.
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Contribution of mast cells to bacterial clearance and their proliferation during experimental cystitis induced by type 1 fimbriated E. coli.
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Contributions of mast cells and vasoactive products, leukotrienes and chymase, to dengue virus-induced vascular leakage.
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Cromolyn ameliorates acute and chronic injury in a rat lung transplant model.
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Cromolyn cream for recalcitrant idiopathic vulvar vestibulitis: results of a placebo controlled study.
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Dengue vascular leakage is augmented by mast cell degranulation mediated by immunoglobulin Fcγ receptors.
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Dengue virus-elicited tryptase induces endothelial permeability and shock.
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Determination of the primary structures of human skin chymase and cathepsin G from cutaneous mast cells of urticaria pigmentosa lesions.
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Development of a novel adjuvanted nasal vaccine: C48/80 associated with chitosan nanoparticles as a path to enhance mucosal immunity.
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Diacylglycerol kinases in immune cell function and self-tolerance.
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Differential Roles of Phospholipase D Proteins in FcεRI-Mediated Signaling and Mast Cell Function.
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Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production.
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Distribution of bronchoconstrictor responses in isolated-perfused rat lung.
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ELKS1 controls mast cell degranulation by regulating the transcription of Stxbp2 and Syntaxin 4 via Kdm2b stabilization.
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Early Immune Response to Acute Gastric Fluid Aspiration in a Rat Model of Lung Transplantation.
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Editorial: Mast Cells: Bridging Host-Microorganism Interactions.
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Effect of beta-adrenergic blockade and sympathetic stimulation on canine bronchial mast cell response to immune degranulation in vivo.
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Effects of topical corticosteroids on human dermis.
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Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1.
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Enhanced expression of mast cell growth factor and mast cell activation in the bladder following the resolution of trinitrobenzenesulfonic acid (TNBS) colitis in female rats.
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Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food-induced anaphylaxis.
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Euthanasia- and Lavage-mediated Effects on Bronchoalveolar Measures of Lung Injury and Inflammation.
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Expression of multiple chemokine genes by a human mast cell leukemia.
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Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE.
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Fine particulate matter (PM2.5) enhances FcεRI-mediated signaling and mast cell function.
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Further characterization of a factor from endotoxin-treated serum which releases histamine and heparin from mast cells.
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Genetic ablation of phosphatidylinositol transfer protein function in murine embryonic stem cells.
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Glycosylphosphatidylinositol-anchored receptor-mediated bacterial endocytosis.
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Harboring of particulate allergens within secretory compartments by mast cells following IgE/FcepsilonRI-lipid raft-mediated phagocytosis.
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Histamine stimulates brain phospholipid turnover through a direct, H-1 receptor-mediated mechanism.
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How mast cells make decisions.
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Human and rat mast cell high-affinity immunoglobulin E receptors: characterization of putative alpha-chain gene products.
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Human skin chymotrypsin-like proteinase chymase. Subcellular localization to mast cell granules and interaction with heparin and other glycosaminoglycans.
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Human skin chymotryptic proteinase. Isolation and relation to cathepsin g and rat mast cell proteinase I.
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Human skin proteinases as inflammatory mediators.
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Identification of Novel Mast Cell Activators Using Cell-Based High-Throughput Screening.
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Immune responses to dengue virus in the skin.
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Immune surveillance by mast cells during dengue infection promotes natural killer (NK) and NKT-cell recruitment and viral clearance.
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Immune synapses between mast cells and γδ T cells limit viral infection.
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Immunology in the Clinic Review Series; focus on allergies: immunotherapy for food allergy.
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Immunomodulatory functions of the diffuse neuroendocrine system: implications for bronchopulmonary dysplasia.
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Impaired degranulation but enhanced cytokine production after Fc epsilonRI stimulation of diacylglycerol kinase zeta-deficient mast cells.
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Impairing oral tolerance promotes allergy and anaphylaxis: a new murine food allergy model.
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In Vitro and In Vivo IgE-/Antigen-Mediated Mast Cell Activation.
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In vivo models for studying mast cell-dependent responses to bacterial infection.
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Independent and cooperative roles of adaptor molecules in proximal signaling during FcepsilonRI-mediated mast cell activation.
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Inflammatory cells degrade inter-alpha inhibitor to liberate urinary proteinase inhibitors.
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Inflammatory response to cardiopulmonary bypass.
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Influence of mast cells on dengue protective immunity and immune pathology.
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Innate immunity and its regulation by mast cells.
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Interaction of Bordetella pertussis with mast cells, modulation of cytokine secretion by pertussis toxin.
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Interaction of bacteria with mast cells.
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Interleukin-9 mediates chronic kidney disease-dependent vein graft disease: a role for mast cells.
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Internalization of FimH+ Escherichia coli by the human mast cell line (HMC-1 5C6) involves protein kinase C.
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Intestinal mast cells mediate gut injury and systemic inflammation in a rat model of deep hypothermic circulatory arrest.
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Involvement of cellular caveolae in bacterial entry into mast cells.
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Iron supplementation decreases severity of allergic inflammation in murine lung.
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Japanese encephalitis virus neuropenetrance is driven by mast cell chymase.
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Kinetics of release of serotonin from isolated secretory granules. I. Amperometric detection of serotonin from electroporated granules.
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Kinetics of release of serotonin from isolated secretory granules. II. Ion exchange determines the diffusivity of serotonin.
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L-selectin or ICAM-1 deficiency reduces an immediate-type hypersensitivity response by preventing mast cell recruitment in repeated elicitation of contact hypersensitivity.
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LAT is essential for Fc(epsilon)RI-mediated mast cell activation.
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Linker for activation of T cells (LAT), a novel immunohistochemical marker for T cells, NK cells, mast cells, and megakaryocytes: evaluation in normal and pathological conditions.
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Loss of Bladder Epithelium Induced by Cytolytic Mast Cell Granules.
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Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis.
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MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection.
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Macrophage imbalance (M1 vs. M2) and upregulation of mast cells in wall of ruptured human cerebral aneurysms: preliminary results.
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Mammalian chymotrypsin-like enzymes. Comparative reactivities of rat mast cell proteases, human and dog skin chymases, and human cathepsin G with peptide 4-nitroanilide substrates and with peptide chloromethyl ketone and sulfonyl fluoride inhibitors.
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Mast cell TNF receptors regulate responses to Mycoplasma pneumoniae in surfactant protein A (SP-A)-/- mice.
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Mast cell activation and arterial hypotension during proximal aortic repair requiring hypothermic circulatory arrest.
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Mast cell activation by Mycobacterium tuberculosis: mediator release and role of CD48.
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Mast cell activators as novel immune regulators.
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Mast cell activators: a new class of highly effective vaccine adjuvants.
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Mast cell degranulation induced by type 1 fimbriated Escherichia coli in mice.
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Mast cell desensitization inhibits calcium flux and aberrantly remodels actin.
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Mast cell function is not altered by Coronin-1A deficiency.
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Mast cell interleukin-10 drives localized tolerance in chronic bladder infection.
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Mast cell mediator responses and their suppression by pathogenic and commensal microorganisms.
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Mast cell modulation of immune responses to bacteria.
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Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha.
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Mast cell modulation of the innate immune response to enterobacterial infection.
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Mast cell modulation of the vascular and lymphatic endothelium.
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Mast cell phagocytosis of FimH-expressing enterobacteria.
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Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter.
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Mast cell regulation of inflammation and gene expression during antigen-induced bladder inflammation in mice.
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Mast cell stabilization improves survival by preventing apoptosis in sepsis.
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Mast cell tryptase: a new biomarker in patients with stable coronary artery disease.
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Mast cell-derived particles deliver peripheral signals to remote lymph nodes.
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Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection.
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Mast cell-orchestrated immunity to pathogens.
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Mast cells and basophils in innate immunity.
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Mast cells are critical for protection against peptic ulcers induced by the NSAID piroxicam.
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Mast cells as modulators of host defense in the lung.
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Mast cells augment adaptive immunity by orchestrating dendritic cell trafficking through infected tissues.
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Mast cells contribute to Enterovirus 71 infection-induced pulmonary edema in neonatal mice.
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Mast cells impair the development of protective anti-tumor immunity.
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Mast cells in infection and immunity.
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Mast cells process bacterial Ags through a phagocytic route for class I MHC presentation to T cells.
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Maternal Immunity and Vaccination Influence Disease Severity in Progeny in a Novel Mast Cell-Deficient Mouse Model of Severe Dengue.
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Mechanisms of nonimmunological histamine and tryptase release from human cutaneous mast cells.
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Mediators, initiating the inflammatory response, released in organ culture by full-thickness human skin explants exposed to the irritant, sulfur mustard.
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Molecular editing of cellular responses by the high-affinity receptor for IgE.
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Mucosal inflammation as a potential etiological factor in irritable bowel syndrome: a systematic review.
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Mucosal targeting of a BoNT/A subunit vaccine adjuvanted with a mast cell activator enhances induction of BoNT/A neutralizing antibodies in rabbits.
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Multiplatform computational analysis of mast cells in adrenocortical carcinoma tumor microenvironment.
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Nasal Immunization With Small Molecule Mast Cell Activators Enhance Immunity to Co-Administered Subunit Immunogens.
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Negative control of mast cell degranulation and the anaphylactic response by the phosphatase lipin1.
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Negative regulation of Fc epsilonRI-mediated signaling and mast cell function by the adaptor protein LAX.
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Neurokinin-1 (NK-1) receptor is required in antigen-induced cystitis.
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Neutrophils Self-Regulate Immune Complex-Mediated Cutaneous Inflammation through CXCL2.
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New perspectives on the origins and heterogeneity of mast cells.
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New roles for mast cells in modulating allergic reactions and immunity against pathogens.
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New roles for mast cells in pathogen defense and allergic disease.
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New twists to an old story: novel concepts in the pathogenesis of allergic eye disease.
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Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation.
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Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS v2.0) identify histologic and molecular correlates of the key clinical features of disease.
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Peripheral serotonin causes dengue virus-induced thrombocytopenia through 5HT2 receptors.
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Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles.
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Phagocytic and tumor necrosis factor alpha response of human mast cells following exposure to gram-negative and gram-positive bacteria.
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Plasticity in mast cell responses during bacterial infections.
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Platelets trigger perivascular mast cell degranulation to cause inflammatory responses and tissue injury.
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Pleomorphic fibroma of the eyelid.
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Potential mechanisms of anaphylaxis to COVID-19 mRNA vaccines.
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Production of TNF-alpha by murine bone marrow derived mast cells activated by the bacterial fimbrial protein, FimH.
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Protective and pathogenic roles for mast cells during viral infections.
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Purification and identification of two serine class proteinases from dog mast biochemically and immunologically similar to human proteinases tryptase and chymase.
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Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase.
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Receptor signaling in immune cell development and function.
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Receptors and signaling mechanisms required for prostaglandin E2-mediated regulation of mast cell degranulation and IL-6 production.
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Regulation of M2-type pyruvate kinase mediated by the high-affinity IgE receptors is required for mast cell degranulation.
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Regulation of mast cell survival and function by tuberous sclerosis complex 1.
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Relation of serum levels of mast cell tryptase of left ventricular systolic function, left ventricular volume or congestive heart failure.
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Requirement for metalloendoprotease in exocytosis: evidence in mast cells and adrenal chromaffin cells.
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Role for endotoxin and complement in periodontal tissue destruction.
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Role of laminin in localization of human dermal mast cells.
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Role of mast cell leukotrienes in neutrophil recruitment and bacterial clearance in infectious peritonitis.
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Role of mast cells in inflammatory bowel disease and inflammation-associated colorectal neoplasia in IL-10-deficient mice.
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STAT6-independent production of IL-4 by mast cells.
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Salmonella typhimurium impedes innate immunity with a mast-cell-suppressing protein tyrosine phosphatase, SptP.
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Simultaneous labeling of mast cell proteases and protease mRNAs at the bone-implant interface of aseptically loosened hip implants.
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Structure and function of the glycosaminoglycan binding site of chemokine macrophage-inflammatory protein-1 beta.
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Studies of the multifaceted mast cell response to bacteria.
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Surfactant protein D decreases pollen-induced IgE-dependent mast cell degranulation.
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Synthetic mast-cell granules as adjuvants to promote and polarize immunity in lymph nodes.
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Systemic Mastocytosis, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology.
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Systemic mastocytosis with associated clonal hematologic nonmast cell lineage disease: a clinicopathologic review.
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TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis.
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Th1-Polarized, Dengue Virus-Activated Human Mast Cells Induce Endothelial Transcriptional Activation and Permeability.
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The 5' non-coding region of the BCR/ABL oncogene augments its ability to stimulate the growth of immature lymphoid cells.
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The IL-2 receptor gamma c chain does not function as a subunit shared by the IL-4 and IL-13 receptors. Implication for the structure of the IL-4 receptor.
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The cutaneous reverse Arthus reaction requires intercellular adhesion molecule 1 and L-selectin expression.
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The immunological axis in heart failure: importance of the leukocyte differential.
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The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors.
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The mast cell activator compound 48/80 is safe and effective when used as an adjuvant for intradermal immunization with Bacillus anthracis protective antigen.
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The mast cell in innate and adaptive immunity.
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The mast cell tumor necrosis factor alpha response to FimH-expressing Escherichia coli is mediated by the glycosylphosphatidylinositol-anchored molecule CD48.
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The mast cell-specific expression of a protease gene, RMCP II, is regulated by an enhancer element that binds specifically to mast cell trans-acting factors.
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The role of Ras guanine nucleotide releasing protein 4 in Fc epsilonRI-mediated signaling, mast cell function, and T cell development.
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The role of mast cells in host defense and their subversion by bacterial pathogens.
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The secretory granule matrix-electrolyte interface: a homologue of the p-n rectifying junction.
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Tissue transglutaminase is expressed, active, and directly involved in rat dermal wound healing and angiogenesis.
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Transcriptional Profiling Confirms the Therapeutic Effects of Mast Cell Stabilization in a Dengue Disease Model.
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Treatment of urticaria pigmentosa with corticosteroids.
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Tryptase activates the mitogen-activated protein kinase/activator protein-1 pathway in human peripheral blood eosinophils, causing cytokine production and release.
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Type 1 fimbriated Escherichia coli-mast cell interactions in cystitis.
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Urticaria pigmentosa. Systemic evaluation and successful treatment with topical steroids.
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Urticaria pigmentosum: nature's experiment in mast cell biology.
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Weal and flare responses to intradermal rocuronium and cisatracurium in humans.
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Wheal and flare responses to muscle relaxants in humans.
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Wheal and flare responses to opioids in humans.
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Keywords of People
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Bao, Evangeline,
Student,
Basic Science Departments
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Gunn, Michael Dee,
Professor of Medicine,
Immunology
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Karhausen, Jorn,
Adjunct Associate Professor in the Department of Anesthesiology,
Anesthesiology, Cardiothoracic
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Krangel, Michael S.,
George Barth Geller Distinguished Professor of Immunology,
Immunology
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Nielsen, Karen Cristina,
Associate Professor of Anesthesiology,
Anesthesiology, Ambulatory
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Stoecker, Maggie Marie,
Assistant Professor of Pathology,
Pathology
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Sunday, Mary Elizabeth Anne,
Professor of Pathology,
Cell Biology
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Zhong, Xiaoping,
Professor of Pediatrics,
Immunology