Mast Cells

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  Subject Areas on Research

  • A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues. 
  • A new cardiac MASTer switch for the renin-angiotensin system. 
  • A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer. 
  • A role for CD21/CD35 and CD19 in responses to acute septic peritonitis: a potential mechanism for mast cell activation. 
  • Adenosine induces airway hyperresponsiveness through activation of A3 receptors on mast cells. 
  • Aggressive topical corticosteroid therapy: a novel approach to mast-cell-dependent cutaneous disorders. 
  • Airway tissue mast cells in persistent asthma: predictor of treatment failure when patients discontinue inhaled corticosteroids. 
  • Alopecia in IL-10-deficient mouse pups is c-kit-dependent and can be triggered by iron deficiency. 
  • An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response. 
  • Analysis of TRPV channel activation by stimulation of FCεRI and MRGPR receptors in mouse peritoneal mast cells. 
  • Anaphylatoxin C3a enhances mucous glycoprotein release from human airways in vitro. 
  • Avoiding Cardiovascular Collapse: Pediatric Cutaneous Mastocytosis and Anesthetic Challenges. 
  • Bacteria-host cell interaction mediated by cellular cholesterol/glycolipid-enriched microdomains. 
  • Biomarkers in the diagnosis of anaphylaxis: making nature disclose her mysteries. 
  • Bombesin-like peptides and mast cell responses: relevance to bronchopulmonary dysplasia? 
  • CD40 mediated activation of gingival and periodontal ligament fibroblasts. 
  • Characterization of bone marrow mast cells in acute myeloid leukemia with t(8;21) (q22;q22); RUNX1-RUNX1T1. 
  • Chemokine production by G protein-coupled receptor activation in a human mast cell line: roles of extracellular signal-regulated kinase and NFAT. 
  • Chemokines have diverse abilities to form solid phase gradients. 
  • Clinical implications of mast cell-bacteria interaction. 
  • Cloning of the mast cell protease, RMCP II. Evidence for cell-specific expression and a multi-gene family. 
  • Contribution of IL-13 to early exocrinopathy in Id3-/- mice. 
  • Contribution of mast cells to bacterial clearance and their proliferation during experimental cystitis induced by type 1 fimbriated E. coli. 
  • Contributions of mast cells and vasoactive products, leukotrienes and chymase, to dengue virus-induced vascular leakage. 
  • Cromolyn ameliorates acute and chronic injury in a rat lung transplant model. 
  • Cromolyn cream for recalcitrant idiopathic vulvar vestibulitis: results of a placebo controlled study. 
  • Ctr2 Regulates Mast Cell Maturation by Affecting the Storage and Expression of Tryptase and Proteoglycans. 
  • Determination of the primary structures of human skin chymase and cathepsin G from cutaneous mast cells of urticaria pigmentosa lesions. 
  • Development of a novel adjuvanted nasal vaccine: C48/80 associated with chitosan nanoparticles as a path to enhance mucosal immunity. 
  • Diacylglycerol kinases in immune cell function and self-tolerance. 
  • Differential Roles of Phospholipase D Proteins in FcεRI-Mediated Signaling and Mast Cell Function. 
  • Differential quantal release of histamine and 5-hydroxytryptamine from mast cells of vesicular monoamine transporter 2 knockout mice. 
  • Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production. 
  • Distribution of bronchoconstrictor responses in isolated-perfused rat lung. 
  • Early Immune Response to Acute Gastric Fluid Aspiration in a Rat Model of Lung Transplantation. 
  • Effect of beta-adrenergic blockade and sympathetic stimulation on canine bronchial mast cell response to immune degranulation in vivo. 
  • Effects of topical corticosteroids on human dermis. 
  • Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1. 
  • Enhanced expression of mast cell growth factor and mast cell activation in the bladder following the resolution of trinitrobenzenesulfonic acid (TNBS) colitis in female rats. 
  • Euthanasia- and Lavage-mediated Effects on Bronchoalveolar Measures of Lung Injury and Inflammation. 
  • Expression of multiple chemokine genes by a human mast cell leukemia. 
  • Further characterization of a factor from endotoxin-treated serum which releases histamine and heparin from mast cells. 
  • Genetic ablation of phosphatidylinositol transfer protein function in murine embryonic stem cells. 
  • Glycosylphosphatidylinositol-anchored receptor-mediated bacterial endocytosis. 
  • Harboring of particulate allergens within secretory compartments by mast cells following IgE/FcepsilonRI-lipid raft-mediated phagocytosis. 
  • Histamine stimulates brain phospholipid turnover through a direct, H-1 receptor-mediated mechanism. 
  • How mast cells make decisions. 
  • Human and rat mast cell high-affinity immunoglobulin E receptors: characterization of putative alpha-chain gene products. 
  • Human skin chymotrypsin-like proteinase chymase. Subcellular localization to mast cell granules and interaction with heparin and other glycosaminoglycans. 
  • Human skin chymotryptic proteinase. Isolation and relation to cathepsin g and rat mast cell proteinase I. 
  • Human skin proteinases as inflammatory mediators. 
  • IL-4 amplifies the pro-inflammatory effect of adenosine in human mast cells by changing expression levels of adenosine receptors. 
  • Immune surveillance by mast cells during dengue infection promotes natural killer (NK) and NKT-cell recruitment and viral clearance. 
  • Immunology in the Clinic Review Series; focus on allergies: immunotherapy for food allergy. 
  • Immunomodulatory functions of the diffuse neuroendocrine system: implications for bronchopulmonary dysplasia. 
  • Impaired degranulation but enhanced cytokine production after Fc epsilonRI stimulation of diacylglycerol kinase zeta-deficient mast cells. 
  • Impairing oral tolerance promotes allergy and anaphylaxis: a new murine food allergy model. 
  • In Vitro and In Vivo IgE-/Antigen-Mediated Mast Cell Activation. 
  • In vivo models for studying mast cell-dependent responses to bacterial infection. 
  • Independent and cooperative roles of adaptor molecules in proximal signaling during FcepsilonRI-mediated mast cell activation. 
  • Inflammatory cells degrade inter-alpha inhibitor to liberate urinary proteinase inhibitors. 
  • Inflammatory events in the blood and airways of guinea pigs immunized to toluene diisocyanate. 
  • Inflammatory response to cardiopulmonary bypass. 
  • Innate immunity and its regulation by mast cells. 
  • Interaction of Bordetella pertussis with mast cells, modulation of cytokine secretion by pertussis toxin. 
  • Interaction of bacteria with mast cells. 
  • Interleukin-9 mediates chronic kidney disease-dependent vein graft disease: a role for mast cells. 
  • Internalization of FimH+ Escherichia coli by the human mast cell line (HMC-1 5C6) involves protein kinase C. 
  • Intestinal mast cells mediate gut injury and systemic inflammation in a rat model of deep hypothermic circulatory arrest. 
  • Involvement of cellular caveolae in bacterial entry into mast cells. 
  • Iron supplementation decreases severity of allergic inflammation in murine lung. 
  • Kinetics of release of serotonin from isolated secretory granules. I. Amperometric detection of serotonin from electroporated granules. 
  • Kinetics of release of serotonin from isolated secretory granules. II. Ion exchange determines the diffusivity of serotonin. 
  • L-selectin or ICAM-1 deficiency reduces an immediate-type hypersensitivity response by preventing mast cell recruitment in repeated elicitation of contact hypersensitivity. 
  • LAT is essential for Fc(epsilon)RI-mediated mast cell activation. 
  • Linker for activation of T cells (LAT), a novel immunohistochemical marker for T cells, NK cells, mast cells, and megakaryocytes: evaluation in normal and pathological conditions. 
  • Loss of Bladder Epithelium Induced by Cytolytic Mast Cell Granules. 
  • Mammalian chymotrypsin-like enzymes. Comparative reactivities of rat mast cell proteases, human and dog skin chymases, and human cathepsin G with peptide 4-nitroanilide substrates and with peptide chloromethyl ketone and sulfonyl fluoride inhibitors. 
  • Mast Cell Deficiency Limits the Development of Chronic Rhinosinusitis in Mice. 
  • Mast cell TNF receptors regulate responses to Mycoplasma pneumoniae in surfactant protein A (SP-A)-/- mice. 
  • Mast cell activation and arterial hypotension during proximal aortic repair requiring hypothermic circulatory arrest. 
  • Mast cell activation by Mycobacterium tuberculosis: mediator release and role of CD48. 
  • Mast cell activators as novel immune regulators. 
  • Mast cell activators: a new class of highly effective vaccine adjuvants. 
  • Mast cell degranulation induced by type 1 fimbriated Escherichia coli in mice. 
  • Mast cell desensitization inhibits calcium flux and aberrantly remodels actin. 
  • Mast cell infiltration: a possible mechanism for vein graft vasospasm. 
  • Mast cell interleukin-10 drives localized tolerance in chronic bladder infection. 
  • Mast cell mediator responses and their suppression by pathogenic and commensal microorganisms. 
  • Mast cell modulation of immune responses to bacteria. 
  • Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha. 
  • Mast cell modulation of the innate immune response to enterobacterial infection. 
  • Mast cell modulation of the vascular and lymphatic endothelium. 
  • Mast cell phagocytosis of FimH-expressing enterobacteria. 
  • Mast cell regulation of inflammation and gene expression during antigen-induced bladder inflammation in mice. 
  • Mast cell-derived particles deliver peripheral signals to remote lymph nodes. 
  • Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection. 
  • Mast cell-orchestrated immunity to pathogens. 
  • Mast cells and basophils in innate immunity. 
  • Mast cells are critical for protection against peptic ulcers induced by the NSAID piroxicam. 
  • Mast cells as modulators of host defense in the lung. 
  • Mast cells augment adaptive immunity by orchestrating dendritic cell trafficking through infected tissues. 
  • Mast cells contribute to Enterovirus 71 infection-induced pulmonary edema in neonatal mice. 
  • Mast cells in infection and immunity. 
  • Mast cells process bacterial Ags through a phagocytic route for class I MHC presentation to T cells. 
  • Mechanisms of nonimmunological histamine and tryptase release from human cutaneous mast cells. 
  • Mediators, initiating the inflammatory response, released in organ culture by full-thickness human skin explants exposed to the irritant, sulfur mustard. 
  • Molecular editing of cellular responses by the high-affinity receptor for IgE. 
  • Mucosal targeting of a BoNT/A subunit vaccine adjuvanted with a mast cell activator enhances induction of BoNT/A neutralizing antibodies in rabbits. 
  • Negative control of mast cell degranulation and the anaphylactic response by the phosphatase lipin1. 
  • Negative regulation of Fc epsilonRI-mediated signaling and mast cell function by the adaptor protein LAX. 
  • Neurokinin-1 (NK-1) receptor is required in antigen-induced cystitis. 
  • New roles for mast cells in modulating allergic reactions and immunity against pathogens. 
  • New roles for mast cells in pathogen defense and allergic disease. 
  • New twists to an old story: novel concepts in the pathogenesis of allergic eye disease. 
  • Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation. 
  • Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS v2.0) identify histologic and molecular correlates of the key clinical features of disease. 
  • Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles. 
  • Phagocytic and tumor necrosis factor alpha response of human mast cells following exposure to gram-negative and gram-positive bacteria. 
  • Plasticity in mast cell responses during bacterial infections. 
  • Production of TNF-alpha by murine bone marrow derived mast cells activated by the bacterial fimbrial protein, FimH. 
  • Prostaglandin E-1: a potential mediator of the inflammatory response. 
  • Purification and identification of two serine class proteinases from dog mast biochemically and immunologically similar to human proteinases tryptase and chymase. 
  • Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase. 
  • Receptor signaling in immune cell development and function. 
  • Receptors and signaling mechanisms required for prostaglandin E2-mediated regulation of mast cell degranulation and IL-6 production. 
  • Regulation of M2-type pyruvate kinase mediated by the high-affinity IgE receptors is required for mast cell degranulation. 
  • Regulation of mast cell survival and function by tuberous sclerosis complex 1. 
  • Requirement for metalloendoprotease in exocytosis: evidence in mast cells and adrenal chromaffin cells. 
  • Role for endotoxin and complement in periodontal tissue destruction. 
  • Role of laminin in localization of human dermal mast cells. 
  • Role of mast cell leukotrienes in neutrophil recruitment and bacterial clearance in infectious peritonitis. 
  • Role of mast cells in inflammatory bowel disease and inflammation-associated colorectal neoplasia in IL-10-deficient mice. 
  • STAT6-independent production of IL-4 by mast cells. 
  • Salmonella typhimurium impedes innate immunity with a mast-cell-suppressing protein tyrosine phosphatase, SptP. 
  • Simultaneous labeling of mast cell proteases and protease mRNAs at the bone-implant interface of aseptically loosened hip implants. 
  • Structure and function of the glycosaminoglycan binding site of chemokine macrophage-inflammatory protein-1 beta. 
  • Studies of the multifaceted mast cell response to bacteria. 
  • Surfactant protein D decreases pollen-induced IgE-dependent mast cell degranulation. 
  • Synthetic mast-cell granules as adjuvants to promote and polarize immunity in lymph nodes. 
  • Systemic mastocytosis with associated clonal hematologic nonmast cell lineage disease: a clinicopathologic review. 
  • TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis. 
  • The 5' non-coding region of the BCR/ABL oncogene augments its ability to stimulate the growth of immature lymphoid cells. 
  • The IL-2 receptor gamma c chain does not function as a subunit shared by the IL-4 and IL-13 receptors. Implication for the structure of the IL-4 receptor. 
  • The beta- and gamma-isoforms of type I PIP5K regulate distinct stages of Ca2+ signaling in mast cells. 
  • The cutaneous reverse Arthus reaction requires intercellular adhesion molecule 1 and L-selectin expression. 
  • The effect of compound 48/80 on contractions induced by toluene diisocyanate in isolated guinea-pig bronchus. 
  • The immunological axis in heart failure: importance of the leukocyte differential. 
  • The mast cell activator compound 48/80 is safe and effective when used as an adjuvant for intradermal immunization with Bacillus anthracis protective antigen. 
  • The mast cell in innate and adaptive immunity. 
  • The mast cell tumor necrosis factor alpha response to FimH-expressing Escherichia coli is mediated by the glycosylphosphatidylinositol-anchored molecule CD48. 
  • The mast cell-specific expression of a protease gene, RMCP II, is regulated by an enhancer element that binds specifically to mast cell trans-acting factors. 
  • The role of Ras guanine nucleotide releasing protein 4 in Fc epsilonRI-mediated signaling, mast cell function, and T cell development. 
  • The role of mast cells in host defense and their subversion by bacterial pathogens. 
  • The secretory granule matrix-electrolyte interface: a homologue of the p-n rectifying junction. 
  • Tissue transglutaminase is expressed, active, and directly involved in rat dermal wound healing and angiogenesis. 
  • Treatment of urticaria pigmentosa with corticosteroids. 
  • Type 1 fimbriated Escherichia coli-mast cell interactions in cystitis. 
  • Urticaria pigmentosa. Systemic evaluation and successful treatment with topical steroids. 
  • Urticaria pigmentosum: nature's experiment in mast cell biology. 
  • Weal and flare responses to intradermal rocuronium and cisatracurium in humans. 
  • Wheal and flare responses to muscle relaxants in humans. 
  • Wheal and flare responses to opioids in humans. 
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  Keywords of People

  • Gunn, Michael Dee, Professor of Medicine, Immunology
  • Karhausen, Jorn, Assistant Professor of Anesthesiology, Anesthesiology, Cardiothoracic
  • Krangel, Michael S., Mary Bernheim Distinguished Professor of Immunology, Immunology
  • Nielsen, Karen Cristina, Associate Professor of Anesthesiology, Anesthesiology, Ambulatory
  • Steinbach, William J., Samuel L. Katz Distinguished Professor of Pediatrics, Duke Innovation & Entrepreneurship
  • Stoecker, Maggie Marie, Assistant Professor of Pathology, Pathology
  • Sunday, Mary Elizabeth Anne, Professor of Pathology, Cell Biology
  • Zhong, Xiaoping, Professor of Pediatrics, Immunology