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Subject Areas on Research
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A murine monoclonal antibody directed against the carboxyl-terminal domain of GRP78 suppresses melanoma growth in mice.
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A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells.
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A tumor-intrinsic PD-L1/NLRP3 inflammasome signaling pathway drives resistance to anti-PD-1 immunotherapy.
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Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2.
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Antigen delivery by alpha(2)-macroglobulin enhances the cytotoxic T lymphocyte response.
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Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy.
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Antigen-presenting cells pulsed with unfractionated tumor-derived peptides are potent tumor vaccines.
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B cells are required for optimal CD4+ and CD8+ T cell tumor immunity: therapeutic B cell depletion enhances B16 melanoma growth in mice.
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Bone marrow-generated dendritic cells pulsed with tumor extracts or tumor RNA induce antitumor immunity against central nervous system tumors.
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CXCR4 enhances adhesion of B16 tumor cells to endothelial cells in vitro and in vivo via beta(1) integrin.
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Chemotactic factor and P15E-related chemotaxis inhibitor in human melanoma cell lines with different macrophage content and tumorigenicity in nude mice.
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Comparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cells.
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Copper Chelation Inhibits BRAFV600E-Driven Melanomagenesis and Counters Resistance to BRAFV600E and MEK1/2 Inhibitors.
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Defective antitumor responses in CX3CR1-deficient mice.
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Dendritic cells engineered to secrete anti-GITR antibodies are effective adjuvants to dendritic cell-based immunotherapy.
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Dendritic cells pulsed with a tumor-specific peptide induce long-lasting immunity and are effective against murine intracerebral melanoma.
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Direct correlation between DNA repair capacity and metastatic potential of K-1735 murine melanoma cells.
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Effect of irradiation on cytokine production, MHC antigen expression, and vaccine potential of interleukin-2 and interferon-gamma gene-modified melanoma cells.
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Effective tumor therapy with plasmid-encoded cytokines combined with in vivo electroporation.
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Effects of hyperthermia and irradiation on the growth of mouse melanoma tumors following immunotherapy.
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Electric field-mediated transport of plasmid DNA in tumor interstitium in vivo.
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Electric fields in tumors exposed to external voltage sources: implication for electric field-mediated drug and gene delivery.
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Electromobility of plasmid DNA in tumor tissues during electric field-mediated gene delivery.
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Enhanced binding and inertness to dehalogenation of alpha-melanotropic peptides labeled using N-succinimidyl 3-iodobenzoate.
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Enhancement of anti-tumor immunity through local modulation of CTLA-4 and GITR by dendritic cells.
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Enhancement of electric field-mediated gene delivery through pretreatment of tumors with a hyperosmotic mannitol solution.
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Enhancement of radiotherapy by hyperthermia-regulated gene therapy.
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Enhancing Radiation Therapy Through Cherenkov Light-Activated Phototherapy.
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Epidermal growth factor receptor VIII peptide vaccination is efficacious against established intracerebral tumors.
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Eradication of melanoma pulmonary metastases by immunotherapy with tumor cells engineered to secrete interleukin-2 or gamma interferon.
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Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells.
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Feasibility of estimating the temperature distribution in a tumor heated by a waveguide applicator.
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Fluorine-18-labeled [Nle4,D-Phe7]-alpha-MSH, an alpha-melanocyte stimulating hormone analogue.
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GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome.
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Gadolinium-conjugated gold nanoshells for multimodal diagnostic imaging and photothermal cancer therapy.
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Gene Expression Profile of Dendritic Cell-Tumor Cell Hybrids Determined by Microarrays and Its Implications for Cancer Immunotherapy.
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Homeostatic proliferation plus regulatory T-cell depletion promotes potent rejection of B16 melanoma.
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Human xenograft-nude mouse model of adoptive immunotherapy with human melanoma-specific cytotoxic T-cells.
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Immune evasion by murine melanoma mediated through CC chemokine receptor-10.
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Immunotherapeutic potential of tumor antigen-pulsed and unpulsed dendritic cells generated from murine bone marrow.
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In vivo expansion, persistence, and function of peptide vaccine-induced CD8 T cells occur independently of CD4 T cells.
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In vivo photoacoustic microscopy with 7.6-µm axial resolution using a commercial 125-MHz ultrasonic transducer.
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In-transit melanoma: the role of alkylating-agent resistance in regional therapy.
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Inhibition of the growth of human melanoma metastases in nude mice by melanoma-specific murine monoclonal antibody.
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Injection of immature dendritic cells into adjuvant-treated skin obviates the need for ex vivo maturation.
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Interferon gamma (IFNgamma) gene transfer of an EMT6 tumor that is poorly responsive to IFNgamma stimulation: increase in tumor immunogenicity is accompanied by induction of a mouse class II transactivator and class II MHC.
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Isolated limb infusion as a model to test new agents to treat metastatic melanoma.
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Label-free oxygen-metabolic photoacoustic microscopy in vivo.
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Local secretion of IL-12 augments the therapeutic impact of dendritic cell-tumor cell fusion vaccination.
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Mechanism of the Antitumor and Radiosensitizing Effects of a Manganese Porphyrin, MnHex-2-PyP.
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Modulation of murine B16F10 melanoma plasminogen activator production by a synthetic peptide derived from the laminin A chain.
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Modulation of specific active immunization against murine melanoma using recombinant cytokines.
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Multivalent RNA aptamers that inhibit CTLA-4 and enhance tumor immunity.
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Nanoparticle Encapsulation of Synergistic Immune Agonists Enables Systemic Codelivery to Tumor Sites and IFNβ-Driven Antitumor Immunity.
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Near-infrared optical imaging of B16 melanoma cells via low-density lipoprotein-mediated uptake and delivery of high emission dipole strength tris[(porphinato)zinc(II)] fluorophores.
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Near-infrared optical imaging of integrin alphavbeta3 in human tumor xenografts.
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Oncolytic virus-derived type I interferon restricts CAR T cell therapy.
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Optimizing a novel regional chemotherapeutic agent against melanoma: hyperthermia-induced enhancement of temozolomide cytotoxicity.
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Osteopontin has a protective role in prostate tumor development in mice.
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Peptide-conjugated PAMAM dendrimer as a universal DNA vaccine platform to target antigen-presenting cells.
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Pericyte-like location of GFP-tagged melanoma cells: ex vivo and in vivo studies of extravascular migratory metastasis.
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Pericytic-like angiotropism of glioma and melanoma cells.
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Photoablation of ocular melanoma with a high-powered argon endolaser.
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Preparation, cytotoxicity, and in vivo antitumor efficacy of 111In-labeled modular nanotransporters.
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Pulsing of dendritic cells with cell lysates from either B16 melanoma or MCA-106 fibrosarcoma yields equally effective vaccines against B16 tumors in mice.
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Regulation of local and metastatic host-mediated anti-tumour mechanisms by L-selectin and intercellular adhesion molecule-1.
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Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival.
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Serological response of non-human primates to human melanoma disialoganglioside GD3.
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Subcutaneous vaccination with irradiated, cytokine-producing tumor cells stimulates CD8+ cell-mediated immunity against tumors located in the "immunologically privileged" central nervous system.
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Superantigen enhanced protection against a weak tumor-specific melanoma antigen: implications for prophylactic vaccination against cancer.
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Targeting Akt3 signaling in malignant melanoma using isoselenocyanates.
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The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia.
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The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction.
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The Preuss Foundation Seminar on vaccine therapy for malignant primary brain tumors. February 15-17, 1998, La Jolla, Calif.
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The effect of high intensity focused ultrasound treatment on metastases in a murine melanoma model.
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The host defense peptide cathelicidin is required for NK cell-mediated suppression of tumor growth.
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Therapeutic vaccine generated by electrofusion of dendritic cells and tumour cells.
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Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody.
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Toll-like receptor agonists as third signals for dendritic cell-tumor fusion vaccines.
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Tuberous sclerosis 1 promotes invariant NKT cell anergy and inhibits invariant NKT cell-mediated antitumor immunity.
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Tumor immunotherapy targeting fibroblast activation protein, a product expressed in tumor-associated fibroblasts.
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Tumor lysate particle loaded dendritic cell vaccine: preclinical testing of a novel personalized cancer vaccine.
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Type III TGF-β receptor downregulation generates an immunotolerant tumor microenvironment.
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UBE2N Promotes Melanoma Growth via MEK/FRA1/SOX10 Signaling.
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Use of murine models of cytokine-secreting tumor vaccines to study feasibility and toxicity issues critical to designing clinical trials.
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Vaccination against the forkhead family transcription factor Foxp3 enhances tumor immunity.
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Whole blood cells loaded with messenger RNA as an anti-tumor vaccine.
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Zinc alpha-2-glycoprotein regulates melanin production by normal and malignant melanocytes.
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Keywords of People
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Cianciolo, George James,
Associate Professor in Pathology,
Pathology
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Hanks, Brent A.,
Associate Professor of Medicine,
Pharmacology & Cancer Biology
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Lee, Walter T,
Professor of Head and Neck Surgery and Communication Sciences,
Radiation Oncology
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McLendon, Roger Edwin,
Professor of Pathology,
Pathology
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Sampson, John Howard,
Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine,
Immunology
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Zhong, Xiaoping,
Professor of Pediatrics,
Immunology