Membrane Glycoproteins

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  Subject Areas on Research

  • "Model" behavior. 
  • 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. 
  • A TRP that makes us feel hyper. 
  • A combined approach for purging multidrug-resistant leukemic cell lines in bone marrow using a monoclonal antibody and chemotherapy. 
  • A disrupted homologue of the human CLN3 or juvenile neuronal ceroid lipofuscinosis gene in Saccharomyces cerevisiae: a model to study Batten disease. 
  • A distinct pattern of cytokine gene expression by human CD83+ blood dendritic cells. 
  • A galactosylceramide binding domain is involved in trafficking of CLN3 from Golgi to rafts via recycling endosomes. 
  • A genome-wide visual screen reveals a role for sphingolipids and ergosterol in cell surface delivery in yeast. 
  • A human CD46 transgenic pig model system for the study of discordant xenotransplantation. 
  • A neural-specific GAP-43 core promoter located between unusual DNA elements that interact to regulate its activity. 
  • A new face of the Rhesus antigen. 
  • A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily. 
  • A novel imaging method for quantitative Golgi localization reveals differential intra-Golgi trafficking of secretory cargoes. 
  • A phase 1 dose-escalation study of NEO-102 in patients with refractory colon and pancreatic cancer. 
  • A phase 2 study of glembatumumab vedotin, an antibody-drug conjugate targeting glycoprotein NMB, in patients with advanced melanoma. 
  • A randomized phase II study of immunization with dendritic cells modified with poxvectors encoding CEA and MUC1 compared with the same poxvectors plus GM-CSF for resected metastatic colorectal cancer. 
  • A role for myocilin in receptor-mediated endocytosis. 
  • A single tube, four-color flow cytometry assay for evaluation of ZAP-70 and CD38 expression in chronic lymphocytic leukemia. 
  • A single valine residue plays an essential role in peripherin/rds targeting to photoreceptor outer segments. 
  • A subset of human monocyte-derived dendritic cells expresses high levels of interleukin-12 in response to combined CD40 ligand and interferon-gamma treatment. 
  • A susceptibility gene for affective disorders and the response of the human amygdala. 
  • A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis. 
  • A transcription factor links growth rate and metabolism in the hypersaline adapted archaeon Halobacterium salinarum. 
  • A yeast metal resistance protein similar to human cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance-associated protein. 
  • A91V is a polymorphism in the perforin gene not causative of an FHLH phenotype. 
  • Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumors. 
  • Aberrant processing of the WSC family and Mid2p cell surface sensors results in cell death of Saccharomyces cerevisiae O-mannosylation mutants. 
  • Aberrant responses in social interaction of dopamine transporter knockout mice. 
  • Abnormalities of circulating T-cell subpopulations in patients with cutaneous T-cell lymphoma: cutaneous lymphocyte-associated antigen expression on T cells correlates with extent of disease. 
  • Abrogation of adenosine A1 receptor signalling improves metabolic regulation in mice by modulating oxidative stress and inflammatory responses. 
  • Activated B cells modified by electroporation of multiple mRNAs encoding immune stimulatory molecules are comparable to mature dendritic cells in inducing in vitro antigen-specific T-cell responses. 
  • Activation of human B cells by phosphorothioate oligodeoxynucleotides. 
  • Acute pancreatitis induces FasL gene expression and apoptosis in the liver. 
  • Adhesion molecules and hydroxyurea in the pathophysiology of sickle cell disease. 
  • Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition. 
  • Affinity-matured anti-glycoprotein NMB recombinant immunotoxins targeting malignant gliomas and melanomas. 
  • AglJ adds the first sugar of the N-linked pentasaccharide decorating the Haloferax volcanii S-layer glycoprotein. 
  • AglR is required for addition of the final mannose residue of the N-linked glycan decorating the Haloferax volcanii S-layer glycoprotein. 
  • Allelic differences in the serotonin transporter-linked polymorphic region in geriatric depression. 
  • Alteration of the CD34+ Tf-1 beta cell line profile in response to long-term exposure to IL-15. 
  • Alterations in serotonin transporter expression in brain regions of rats exposed neonatally to chlorpyrifos. 
  • Altered toll-like receptor responsiveness underlies a dominant heritable defect in B cell tolerance in autoimmune New Zealand Black mice. 
  • Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci. 
  • Amelioration of collagen-induced arthritis by CD95 (Apo-1/Fas)-ligand gene transfer. 
  • Aminoaciduria and altered renal expression of luminal amino acid transporters in mice lacking novel gene collectrin. 
  • An L-selectin ligand distinct from P-selectin glycoprotein ligand-1 is expressed on endothelial cells and promotes neutrophil rolling in inflammation. 
  • An animal model of attention deficit hyperactivity disorder. 
  • An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis. 
  • An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina. 
  • Angiogenic growth factors in the pathophysiology of a murine model of acute lung injury. 
  • Ankyrin binding activity shared by the neurofascin/L1/NrCAM family of nervous system cell adhesion molecules. 
  • Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments. 
  • Ankyrin-binding activity of nervous system cell adhesion molecules expressed in adult brain. 
  • Ankyrin-binding proteins related to nervous system cell adhesion molecules: candidates to provide transmembrane and intercellular connections in adult brain. 
  • Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter. 
  • Anti-tumour activity and store operated calcium entry: new roles in immunology. 
  • Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2. 
  • Antibodies with high avidity to the gp120 envelope protein in protection from simian immunodeficiency virus SIV(mac251) acquisition in an immunization regimen that mimics the RV-144 Thai trial. 
  • Antiproliferative action of dopamine and norepinephrine in neuroblastoma cells expressing the human dopamine transporter. 
  • Antiseizure effects of TrkB kinase inhibition. 
  • Apolipoprotein E4 stimulates cAMP response element-binding protein transcriptional activity through the extracellular signal-regulated kinase pathway. 
  • Apoptosis and B cell tolerance. 
  • Apoptosis and heart failure. 
  • Approaches to identify monoamine transporter interacting proteins. 
  • Assembly of translocation-competent proteoliposomes from detergent-solubilized rough microsomes. 
  • Assessment of the genetic variance of late-onset Alzheimer's disease. 
  • Associations among the NEO Personality Inventory, Revised and the serotonin transporter gene-linked polymorphic region in elders: effects of depression and gender. 
  • Autocrine BDNF-TrkB signalling within a single dendritic spine. 
  • Autoradiographic quantification of neurochemical markers of serotonin, dopamine and opioid systems in rat brain mesolimbic regions following chronic St John's wort treatment. 
  • Bacterial penetration of bladder epithelium through lipid rafts. 
  • Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice. 
  • Biomarkers of inflammation - LBP and TLR- predict progression of knee osteoarthritis in the DOXY clinical trial. 
  • Blood group antigens on complement receptor/regulatory proteins. 
  • Bone histomorphometric and biomechanical abnormalities in mice homozygous for deletion of the dopamine transporter gene. 
  • Bone-related genes expressed in advanced malignancies induce invasion and metastasis in a genetically defined human cancer model. 
  • Bromelain treatment of human T cells removes CD44, CD45RA, E2/MIC2, CD6, CD7, CD8, and Leu 8/LAM1 surface molecules and markedly enhances CD2-mediated T cell activation. 
  • C3b receptor activity on transfected cells expressing glycoprotein C of herpes simplex virus types 1 and 2. 
  • CAR T Cells Targeting Podoplanin Reduce Orthotopic Glioblastomas in Mouse Brains. 
  • CD1 expression by dendritic cells in human leprosy lesions: correlation with effective host immunity. 
  • CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells. 
  • CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes. 
  • CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse. 
  • CD34+CD38-lin- cord blood cells develop into dendritic cells in human thymic stromal monolayers and thymic nodules. 
  • CD40 is a functional activation antigen and B7-independent T cell costimulatory molecule on normal human lung fibroblasts. 
  • CD40 ligand (CD154) triggers a short-term CD4(+) T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis. 
  • CD40 ligand-dependent T cell activation: requirement of B7-CD28 signaling through CD40. 
  • CD40 mediated activation of gingival and periodontal ligament fibroblasts. 
  • CD44 antibody against In(Lu)-related p80, lymphocyte-homing receptor molecule inhibits the binding of human erythrocytes to T cells. 
  • CD7 and CD28 are required for murine CD4+CD25+ regulatory T cell homeostasis and prevention of thyroiditis. 
  • CD8+ lymphocyte activation at human immunodeficiency virus type 1 seroconversion: development of HLA-DR+ CD38- CD8+ cells is associated with subsequent stable CD4+ cell levels. The Multicenter AIDS Cohort Study Group. 
  • CD83 expression influences CD4+ T cell development in the thymus. 
  • CD83 expression is a sensitive marker of activation required for B cell and CD4+ T cell longevity in vivo. 
  • CD83 influences cell-surface MHC class II expression on B cells and other antigen-presenting cells. 
  • CD83: a regulatory molecule of the immune system with great potential for therapeutic application. 
  • CD86 (B7-2) can function to drive MHC-restricted antigen-specific CTL responses in vivo. 
  • CD9 plays a role in Schwann cell migration in vitro. 
  • CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin. 
  • CLN3 defines a novel antiapoptotic pathway operative in neurodegeneration and mediated by ceramide. 
  • CLN3p impacts galactosylceramide transport, raft morphology, and lipid content. 
  • COBRA encodes a putative GPI-anchored protein, which is polarly localized and necessary for oriented cell expansion in Arabidopsis. 
  • COBRA, an Arabidopsis extracellular glycosyl-phosphatidyl inositol-anchored protein, specifically controls highly anisotropic expansion through its involvement in cellulose microfibril orientation. 
  • CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates. 
  • Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis. 
  • Calcium entry in skeletal muscle. 
  • Calcium flux and endothelial dysfunction during acute lung injury: a STIMulating target for therapy. 
  • Catecholamine release and uptake in the mouse prefrontal cortex. 
  • Catecholamine transporters and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity: studies comparing the cloned human noradrenaline and human dopamine transporter. 
  • Cell adhesion molecule L1 in folded (horseshoe) and extended conformations. 
  • Cell adhesion molecules involved in intrathymic T cell development. 
  • Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model. 
  • Cell biology. Propelling progeny. 
  • Cell biology: How to combat stress. 
  • Cell wall mannan and cell surface hydrophobicity in Candida albicans serotype A and B strains. 
  • Cell wall protein mannosylation determines Candida albicans cell surface hydrophobicity. 
  • Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers. 
  • Center stage for the serotonin transporter: a gain-of-function polymorphism in persons with obsessive-compulsive disorder. 
  • Central nervous system serotonin function and cardiovascular responses to stress. 
  • Changes in the rate of laminin and entactin synthesis in F9 embryonal carcinoma cells treated with retinoic acid and cyclic amp. 
  • Characterization of C1q receptor expression on human phagocytic cells: effects of PDBu and fMLP. 
  • Characterization of a novel family of ciliary body glycoproteins. 
  • Characterization of alpha 2-macroglobulin binding to human trabecular meshwork cells: presence of the alpha 2-macroglobulin signaling receptor. 
  • Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients. 
  • Characterization of dendritic-like cells derived from t(9;22) acute lymphoblastic leukemia blasts. 
  • Characterization of the human B cell RAG-associated gene, hBRAG, as a B cell receptor signal-enhancing glycoprotein dimer that associates with phosphorylated proteins in resting B cells. 
  • Characterization of the surface topography and putative tertiary structure of the human CD7 molecule. 
  • Chemiluminescence and the Nox1-Nox2-Nox4 Triple Knockout. 
  • Circulating Kidney Injury Molecule-1 Levels in Acute Heart Failure: Insights From the ASCEND-HF Trial (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure). 
  • Clinical isolates of measles virus use CD46 as a cellular receptor. 
  • Cloning and functional characterization of a cocaine-sensitive dopamine transporter. 
  • Cloning of the human glycine transporter type 1: molecular and pharmacological characterization of novel isoform variants and chromosomal localization of the gene in the human and mouse genomes. 
  • Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter. 
  • Cocaine and amphetamine elicit differential effects in rats with a unilateral injection of dopamine transporter antisense oligodeoxynucleotides. 
  • Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions. 
  • Cocaine self-administration in dopamine-transporter knockout mice. 
  • Combination induction therapy with monoclonal antibodies specific for CD80, CD86, and CD154 in nonhuman primate renal transplantation. 
  • Combining expression and comparative evolutionary analysis. The COBRA gene family. 
  • Comparison of molecular markers in a cohort of patients with chronic myeloproliferative disorders. 
  • Comparison of thymocyte development and cytokine production in CD7-deficient, CD28-deficient and CD7/CD28 double-deficient mice. 
  • Complement control proteins, CD46, CD55, and CD59, as common surface constituents of human and simian immunodeficiency viruses and possible targets for vaccine protection. 
  • Complement-induced vesiculation and exposure of membrane prothrombinase sites in platelets of paroxysmal nocturnal hemoglobinuria. 
  • Concentrated RD114-pseudotyped MFGS-gp91phox vector achieves high levels of functional correction of the chronic granulomatous disease oxidase defect in NOD/SCID/beta -microglobulin-/- repopulating mobilized human peripheral blood CD34+ cells. 
  • Concurrent autoreceptor-mediated control of dopamine release and uptake during neurotransmission: an in vivo voltammetric study. 
  • Conditional deletion of TrkC does not modify limbic epileptogenesis. 
  • Convergent control of serotonin transporter expression by glucocorticoids and cocaine in fetal and neonatal rat brain. 
  • Coordinate regulation of the alpha(2)-macroglobulin signaling receptor and the low density lipoprotein receptor-related protein/alpha(2)-macroglobulin receptor by insulin. 
  • Costimulatory molecules are active in the human xenoreactive T-cell response but not in natural killer-mediated cytotoxicity. 
  • Cotransfection of DC with TLR4 and MART-1 RNA induces MART-1-specific responses. 
  • Cutting edge: ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells. 
  • Cutting edge: trimolecular interaction of TCR with MHC class II and bacterial superantigen shows a similar affinity to MHC:peptide ligands. 
  • Cyclic AMP-dependent protein kinase regulates pseudohyphal differentiation in Saccharomyces cerevisiae. 
  • Decreased ethanol preference and consumption in dopamine transporter female knock-out mice. 
  • Delineation of discrete domains for substrate, cocaine, and tricyclic antidepressant interactions using chimeric dopamine-norepinephrine transporters. 
  • Dendritic cell CD83: a therapeutic target or innocent bystander? 
  • Dendritic cells cultured in anti-CD40 antibody-immobilized plates elicit a highly efficient peptide-specific T-cell response. 
  • Dendritic cells infected with a vaccinia vector carrying the human gp100 gene simultaneously present multiple specificities and elicit high-affinity T cells reactive to multiple epitopes and restricted by HLA-A2 and -A3. 
  • Depressed platelet status in an elderly patient with hemorrhagic stroke after thrombolysis for acute myocardial infarction. GUSTO-III Investigators. 
  • Desmoplakin I and desmoplakin II. Purification and characterization. 
  • Development and validation of a cell-based fluorescent method for measuring antibody affinity. 
  • Development of a rapid whole blood flow cytometry procedure for the diagnosis of X-linked hyper-IgM syndrome patients and carriers. 
  • Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling. 
  • Developmental exposure to terbutaline and chlorpyrifos: pharmacotherapy of preterm labor and an environmental neurotoxicant converge on serotonergic systems in neonatal rat brain regions. 
  • Diagnosis of fungal infection: new technologies for the mycology laboratory. 
  • Differences between the effect of anisotropic and isotropic laminin and nerve growth factor presenting scaffolds on nerve regeneration across long peripheral nerve gaps. 
  • Differences in platelet serotonin transporter sites between African-American tobacco smokers and non-smokers. 
  • Differences in the acid-labile component of Candida albicans mannan from hydrophobic and hydrophilic yeast cells. 
  • Different routes to the same ending: comparing the N-glycosylation processes of Haloferax volcanii and Haloarcula marismortui, two halophilic archaea from the Dead Sea. 
  • Differential psychostimulant-induced activation of neural circuits in dopamine transporter knockout and wild type mice. 
  • Differential pulmonary transcriptomic profiles in murine lungs infected with low and highly virulent influenza H3N2 viruses reveal dysregulation of TREM1 signaling, cytokines, and chemokines. 
  • Differential quantal release of histamine and 5-hydroxytryptamine from mast cells of vesicular monoamine transporter 2 knockout mice. 
  • Differential recognition by proteins of alpha-galactosyl residues on endothelial cell surfaces. 
  • Differential regulation of the dopamine D1, D2 and D3 receptor gene expression and changes in the phenotype of the striatal neurons in mice lacking the dopamine transporter. 
  • Differential regulation of tyrosine hydroxylase in the basal ganglia of mice lacking the dopamine transporter. 
  • Differentiation of human T lymphocytes: II. Phenotypic difference in skin and blood malignant T-cells in cutaneous T-cell lymphoma. 
  • Dissimilar neuropsychiatric presentations of two siblings with juvenile neuronal ceroid lipofuscinosis (Batten disease). 
  • Distinct glycan-charged phosphodolichol carriers are required for the assembly of the pentasaccharide N-linked to the Haloferax volcanii S-layer glycoprotein. 
  • Disulfide-mediated dimerization of L1 Ig domains. 
  • Do glucocorticoids contribute to the abnormalities in serotonin transporter expression and function seen in depression? An animal model. 
  • Dopamine genes and ADHD. 
  • Dopamine neuronal transport kinetics and effects of amphetamine. 
  • Dopamine tone regulates D1 receptor trafficking and delivery in striatal neurons in dopamine transporter-deficient mice. 
  • Dopamine transporter expression confers cytotoxicity to low doses of the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium. 
  • Dopamine transporter is required for in vivo MPTP neurotoxicity: evidence from mice lacking the transporter. 
  • Dopamine transporter-dependent and -independent actions of trace amine beta-phenylethylamine. 
  • Dopamine transporters and neuronal injury. 
  • Down-regulation of the orphan nuclear receptor ROR gamma t is essential for T lymphocyte maturation. 
  • Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events. 
  • Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation. 
  • Dysregulation of hedgehog signalling predisposes to synovial chondromatosis. 
  • Effect of torsinA on membrane proteins reveals a loss of function and a dominant-negative phenotype of the dystonia-associated DeltaE-torsinA mutant. 
  • Effects of titanium particle size on osteoblast functions in vitro and in vivo. 
  • Efficient cross-priming of antiviral CD8+ T cells by antigen donor cells is GRP94 independent. 
  • Emerging concepts in acute kidney injury following cardiac surgery. 
  • Endocytosis and synaptic removal of NR3A-containing NMDA receptors by PACSIN1/syndapin1. 
  • Endogenous expression of transforming growth factor beta1 inhibits growth and tumorigenicity and enhances Fas-mediated apoptosis in a murine high-grade glioma model. 
  • Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. 
  • Engineering DNA vaccines via co-delivery of co-stimulatory molecule genes. 
  • Enteroviral meningoencephalitis as a complication of X-linked hyper IgM syndrome. 
  • Epithelioid osteosarcoma of bone. Immunocytochemical evidence suggesting divergent epithelial and mesenchymal differentiation in a primary osseous neoplasm. 
  • Erp72 expression activated by transient cerebral ischemia or disturbance of neuronal endoplasmic reticulum calcium stores. 
  • Erythrocyte adhesion receptors: blood group antigens and related molecules. 
  • Erythrocyte blood group antigens: not so simple after all. 
  • Erythroid-specific expression of human CD59 and transfer to vascular endothelial cells. 
  • Evaluation of anti-podoplanin rat monoclonal antibody NZ-1 for targeting malignant gliomas. 
  • Evidence for polyreactive xenoreactive antibodies in the repertoire of human anti-swine antibodies: the 'next' humoral barrier to xenotransplantation? 
  • Evidence for positive and negative regulatory elements in the 5'-flanking sequence of the mouse sparc (osteonectin) gene. 
  • Evidence of fibroblast heterogeneity and the role of fibroblast subpopulations in fibrosis. 
  • Evidence of uncoupling between renal dysfunction and injury in cardiorenal syndrome: insights from the BIONICS study. 
  • Expansion of tumor-T cell pairs from fine needle aspirates of melanoma metastases. 
  • Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor. 
  • Expression cloning and characterization of the TGF-beta type III receptor. 
  • Expression of cell-adhesion molecules in the salivary gland microenvironment of Sjögren's syndrome. 
  • Expression of cln3 in human NT2 neuronal precursor cells and neonatal rat brain. 
  • Expression of mRNA coding for the serotonin transporter in aged vs. young rat brain: differential effects of glucocorticoids. 
  • Expression of multidrug resistance gene mdr1 mRNA in a subset of normal bone marrow cells. 
  • Expression of the intermediate filament peripherin in extraskeletal myxoid chondrosarcoma. 
  • Expression of tumor-suppressor genes interferon regulatory factor 1 and death-associated protein kinase in primitive acute myelogenous leukemia cells. 
  • Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1. 
  • FIGQY phosphorylation defines discrete populations of L1 cell adhesion molecules at sites of cell-cell contact and in migrating neurons. 
  • Fas on renal parenchymal cells does not promote autoimmune nephritis in MRL mice. 
  • Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations. 
  • Fas/FasL play a central role in pancreatitis-induced hepatocyte apoptosis. 
  • Fate of GAP-43 in ascending spinal axons of DRG neurons after peripheral nerve injury: delayed accumulation and correlation with regenerative potential. 
  • Fetal and adolescent nicotine administration: effects on CNS serotonergic systems. 
  • Flupirtine blocks apoptosis in batten patient lymphoblasts and in human postmitotic CLN3- and CLN2-deficient neurons. 
  • Frequency of MART-1/MelanA and gp100/PMel17-specific T cells in tumor metastases and cultured tumor-infiltrating lymphocytes. 
  • Frequent loss of KAI1 expression in squamous and lymphoid neoplasms. An immunohistochemical study of archival tissues. 
  • Functional Variants in Notch Pathway Genes NCOR2, NCSTN, and MAML2 Predict Survival of Patients with Cutaneous Melanoma. 
  • Functional heterogeneity of vaccine-induced CD8(+) T cells. 
  • Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1. 
  • Functional polymorphisms in the promoter regions of the FAS and FAS ligand genes and risk of bladder cancer in south China: a case-control analysis. 
  • Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. 
  • GAP-43 as a 'calmodulin sponge' and some implications for calcium signalling in axon terminals. 
  • GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination. 
  • GPI-defective monocytes from paroxysmal nocturnal hemoglobinuria patients show impaired in vitro dendritic cell differentiation. 
  • GRP94 (gp96) and GRP94 N-terminal geldanamycin binding domain elicit tissue nonrestricted tumor suppression. 
  • Gene expression patterns that characterize advanced stage serous ovarian cancers. 
  • Gene expression profiling and genetic markers in glioblastoma survival. 
  • Generation of dendritic cells in vitro from peripheral blood mononuclear cells with granulocyte-macrophage-colony-stimulating factor, interleukin-4, and tumor necrosis factor-alpha for use in cancer immunotherapy. 
  • Genes for the neuronal immunoglobulin domain cell adhesion molecules neurofascin and Nr-CAM map to mouse chromosomes 1 and 12 and homologous human chromosomes. 
  • Genetics of childhood disorders: XXIV. ADHD, part 8: hyperdopaminergic mice as an animal model of ADHD. 
  • Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk. 
  • Genomic complexity identifies patients with aggressive chronic lymphocytic leukemia. 
  • Genotype-phenotype correlations and differential diagnosis in autosomal dominant macular disease. 
  • Gentamicin inhibits rat renal cortical homotypic endosomal fusion: role of megalin. 
  • Glutamatergic modulation of hyperactivity in mice lacking the dopamine transporter. 
  • Glyco-engineering in Archaea: differential N-glycosylation of the S-layer glycoprotein in a transformed Haloferax volcanii strain. 
  • Glycoprotein 96 perpetuates the persistent inflammation of rheumatoid arthritis. 
  • Glycoprotein nonmetastatic melanoma protein B, a potential molecular therapeutic target in patients with glioblastoma multiforme. 
  • Glycosyl-phosphatidylinositol anchor synthesis in paroxysmal nocturnal hemoglobinuria: partial or complete defect in an early step. 
  • Glycosylphosphatidylinositol (GPI) Modification Serves as a Primary Plasmodesmal Sorting Signal. 
  • Gp91phox contributes to NADPH oxidase activity in aortic fibroblasts but not smooth muscle cells. 
  • Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS. 
  • H(2)O(2)-induced O(2) production by a non-phagocytic NAD(P)H oxidase causes oxidant injury. 
  • Heparin enhances uptake of platelet factor 4/heparin complexes by monocytes and macrophages. 
  • Hepatic allograft-derived Kupffer cells regulate T cell response in rats. 
  • Hepatic enrichment and activation of myeloid dendritic cells during chronic hepatitis C virus infection. 
  • High expression of tumor necrosis factor-related apoptosis-inducing ligand is associated with favorable ovarian cancer survival. 
  • High-frequency S-layer protein variation in Campylobacter fetus revealed by sapA mutagenesis. 
  • Higher Peripheral TREM2 mRNA Levels Relate to Cognitive Deficits and Hippocampal Atrophy in Alzheimer's Disease and Amnestic Mild Cognitive Impairment. 
  • Histologic observations and P-glycoprotein expression in gastric and esophageal adenocarcinomas treated with preoperative chemotherapy. 
  • Host genetics: fine-tuning innate signaling. 
  • Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. 
  • Human dendritic cells, pulsed with either melanoma tumor cell lysates or the gp100 peptide(280-288), induce pairs of T-cell cultures with similar phenotype and lytic activity. 
  • Human dopamine transporter gene not linked to schizophrenia in multigenerational pedigrees. 
  • Human orbital fibroblasts are activated through CD40 to induce proinflammatory cytokine production. 
  • Hydrophobic cell wall protein glycosylation by the pathogenic fungus Candida albicans. 
  • Hydrophobic surface protein masking by the opportunistic fungal pathogen Candida albicans. 
  • Hyper IgM syndrome associated with defective CD40-mediated B cell activation. 
  • Hyperactivity and impaired response habituation in hyperdopaminergic mice. 
  • Hyperadhesive mutant of type 1-fimbriated Escherichia coli associated with formation of FimH organelles (fimbriosomes). 
  • Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. 
  • Identification of a novel repressive element that contributes to neuron-specific gene expression. 
  • Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice. 
  • Identification of novel Runx2 targets in osteoblasts: cell type-specific BMP-dependent regulation of Tram2. 
  • Identification of two novel mutations in families with X-linked ocular albinism. 
  • Images in neuroscience. A mouse knockout. 
  • Images in neuroscience. Molecular biology, II. A dopamine transporter mouse knockout. 
  • Imaging genomics. 
  • Immortalized rat proximal tubule cells produce membrane bound and soluble megalin. 
  • Immunohistologic analysis of the distribution of cell adhesion molecules within the inflammatory synovial microenvironment. 
  • Improved protection of rhesus macaques against intrarectal simian immunodeficiency virus SIV(mac251) challenge by a replication-competent Ad5hr-SIVenv/rev and Ad5hr-SIVgag recombinant priming/gp120 boosting regimen. 
  • In Reply to 'Neutrophil Gelatinase-Associated Lipocalin (NGAL), Neutrophils, and CKD: Which Comes First?'. 
  • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance. 
  • In vitro and in vivo expression of a nephritogenic Ig heavy chain determinant: pathogenic autoreactivity requires permissive light chains. 
  • In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs. 
  • In vitro synthesis of laminin and entactin polypeptides. 
  • In vivo transfer of GPI-linked complement restriction factors from erythrocytes to the endothelium. 
  • Inactivation of the dopamine transporter reveals essential roles of dopamine in the control of locomotion, psychostimulant response, and pituitary function. 
  • Increased MPTP neurotoxicity in vesicular monoamine transporter 2 heterozygote knockout mice. 
  • Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha. 
  • Increased methamphetamine neurotoxicity in heterozygous vesicular monoamine transporter 2 knock-out mice. 
  • Increased rewarding properties of morphine in dopamine-transporter knockout mice. 
  • Increased vaccine-specific T cell frequency after peptide-based vaccination correlates with increased susceptibility to in vitro stimulation but does not lead to tumor regression. 
  • Inducing unresponsiveness by the use of anti-CD3 immunotoxin, CTLA4-Ig, and anti-CD40 ligand. 
  • Induction of human dendritic cell maturation using transfection with RNA encoding a dominant positive toll-like receptor 4. 
  • Induction therapy with monoclonal antibodies specific for CD80 and CD86 delays the onset of acute renal allograft rejection in non-human primates. 
  • Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. 
  • Influence of serotonin transporter promoter region polymorphisms on hippocampal volumes in late-life depression. 
  • Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II. 
  • Injury-associated induction of GAP-43 expression displays axon branch specificity in rat dorsal root ganglion neurons. 
  • Innate immunity influences long-term outcomes after human lung transplant. 
  • Interaction Between Peroxisome Proliferator Activated Receptor δ and Epithelial Membrane Protein 2 Polymorphisms Influences HDL-C Levels in the Chinese Population. 
  • Interaction of TLR2 and TLR4 ligands with the N-terminal domain of Gp96 amplifies innate and adaptive immune responses. 
  • Interaction of a 60-kilodalton D-mannose-containing salivary glycoprotein with type 1 fimbriae of Escherichia coli. 
  • Interaction of prenylcysteine methyl esters with the multidrug resistance transporter. 
  • Interactions between dystrophin and the sarcolemma membrane. 
  • Interleukin-15 augments superoxide production and microbicidal activity of human monocytes against Candida albicans. 
  • Intracellular adhesion molecule-1 modulates beta-chemokines and directly costimulates T cells in vivo. 
  • Intrinsically determined cell death of developing cortical interneurons. 
  • Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins. 
  • Kinetics of TCR use in response to repeated epitope-specific immunization. 
  • Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine. 
  • Kupffer cell-derived Fas ligand plays a role in liver injury and hepatocyte death. 
  • L-DOPA is an endogenous ligand for OA1. 
  • L-selectin binds to P-selectin glycoprotein ligand-1 on leukocytes: interactions between the lectin, epidermal growth factor, and consensus repeat domains of the selectins determine ligand binding specificity. 
  • L-selectin dimerization enhances tether formation to properly spaced ligand. 
  • L-selectin ligands expressed by human leukocytes are HECA-452 antibody-defined carbohydrate epitopes preferentially displayed by P-selectin glycoprotein ligand-1. 
  • LAD-1, the Caenorhabditis elegans L1CAM homologue, participates in embryonic and gonadal morphogenesis and is a substrate for fibroblast growth factor receptor pathway-dependent phosphotyrosine-based signaling. 
  • LKLF: A transcriptional regulator of single-positive T cell quiescence and survival. 
  • Lack of B cell dysfunction is associated with functional, gp120-dominant antibody responses in breast milk of simian immunodeficiency virus-infected African green monkeys. 
  • Laser scanning cytometry evaluation of MART-1, gp100, and HLA-A2 expression in melanoma metastases. 
  • Leukocyte interactions with vascular endothelium. New insights into selectin-mediated attachment and rolling. 
  • Levodopa and the progression of Parkinson's disease. 
  • Ligand binding to the LFA-3 cell adhesion molecule induces IL-1 production by human thymic epithelial cells. 
  • Lipid modification gives rise to two distinct Haloferax volcanii S-layer glycoprotein populations. 
  • Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14. 
  • Localization of fibronectin, laminin-entactin, and entactin in Reichert's membrane by immunoelectron microscopy. 
  • Location and role of free cysteinyl residues in the Sindbis virus E1 and E2 glycoproteins. 
  • Location of WESb on decay-accelerating factor. 
  • Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD154. 
  • Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154. 
  • Longitudinal study of differential protein expression in an Alzheimer's mouse model lacking inducible nitric oxide synthase. 
  • Loss of Epithelial Membrane Protein 2 Aggravates Podocyte Injury via Upregulation of Caveolin-1. 
  • Loss of KAI1 expression in the progression of colorectal cancer. 
  • Loss of autoreceptor functions in mice lacking the dopamine transporter. 
  • Loss of the perforin cytotoxic pathway predisposes mice to experimental cytomegalovirus retinitis. 
  • Lymphadenopathy, splenomegaly, and altered immunoglobulin production in BCL3 transgenic mice. 
  • Lymphangitis after self-administration of lipopolysaccharide. 
  • MDMA "ecstasy" alters hyperactive and perseverative behaviors in dopamine transporter knockout mice. 
  • MUC1 mucin expression as a marker of progression and metastasis of human colorectal carcinoma. 
  • Macrophage-dependent induction of the Salmonella pathogenicity island 2 type III secretion system and its role in intracellular survival. 
  • Magnetic resonance imaging at microscopic resolution reveals subtle morphological changes in a mouse model of dopaminergic hyperfunction. 
  • Mast cell modulation of the innate immune response to enterobacterial infection. 
  • Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment. 
  • Measurement of an adhesion molecule as an indicator of inflammatory disease activity. Up-regulation of the receptor for hyaluronate (CD44) in rheumatoid arthritis. 
  • Mechanism for binding site diversity on ankyrin. Comparison of binding sites on ankyrin for neurofascin and the Cl-/HCO3- anion exchanger. 
  • Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter. 
  • Melanoma, a tumor based on a mutant stem cell? 
  • Mice lacking the dopamine transporter display altered regulation of distal colonic motility. 
  • Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis. 
  • Microarray analysis of early stage serous ovarian cancers shows profiles predictive of favorable outcome. 
  • Mild and severe muscular dystrophy caused by a single gamma-sarcoglycan mutation. 
  • Missense mutations in TENM4, a regulator of axon guidance and central myelination, cause essential tremor. 
  • Modeling geriatric depression in animals: biochemical and behavioral effects of olfactory bulbectomy in young versus aged rats. 
  • Modifications of the human immunodeficiency virus envelope glycoprotein enhance immunogenicity for genetic immunization. 
  • Modulation of the intracellular Ca2+ and inositol trisphosphate concentrations in murine T lymphocytes by the glycosylphosphatidylinositol-anchored protein sgp-60. 
  • Molecular analysis of the cDNA for human SPARC/osteonectin/BM-40: sequence, expression, and localization of the gene to chromosome 5q31-q33. 
  • Molecular basis of reduced or absent expression of decay-accelerating factor in Cromer blood group phenotypes. 
  • Molecular characterization of the dopamine transporter. 
  • Molecular composition of the node of Ranvier: identification of ankyrin-binding cell adhesion molecules neurofascin (mucin+/third FNIII domain-) and NrCAM at nodal axon segments. 
  • Molecular control of steady-state dendritic cell maturation and immune homeostasis. 
  • Molecular mapping of the Cromer blood group Cra and Tca epitopes of decay accelerating factor: toward the use of recombinant antigens in immunohematology. 
  • Monitoring changes in gene expression in renal ischemia-reperfusion in the rat. 
  • Monoclonal antibody against human T cell leukemia virus p19 defines a human thymic epithelial antigen acquired during ontogeny. 
  • More about use of the term Drb. 
  • Motifs within the CLN3 protein: modulation of cell growth rates and apoptosis. 
  • Multiparameter-fluorescence activated cell sorting analysis of retroviral vector gene transfer into primitive umbilical cord blood cells. 
  • Multiple elements may be used for regulation of the GAP-43 gene in different cell-types. 
  • Multiple signals are required for maturation of human dendritic cells mobilized in vivo with Flt3 ligand. 
  • Multisite comparison of methods for the quantitation of the surface expression of CD38 on CD8(+) T lymphocytes. The ACTG Advanced Flow Cytometry Focus Group. 
  • Murine cytomegalovirus retinitis during retrovirus-induced immunodeficiency (MAIDS) in mice: interleukin-2 immunotherapy correlates with increased intraocular levels of perforin mRNA. 
  • Murine dendritic cells transfected with human GP100 elicit both antigen-specific CD8(+) and CD4(+) T-cell responses and are more effective than DNA vaccines at generating anti-tumor immunity. 
  • Mutations in EMP2 cause childhood-onset nephrotic syndrome. 
  • Mutations that destabilize the gp41 core are determinants for stabilizing the simian immunodeficiency virus-CPmac envelope glycoprotein complex. 
  • Myelodysplasia and deficiency of uridine diphosphate-galactose 4-epimerase. 
  • Myeloma light chains are ligands for cubilin (gp280). 
  • NOX2 protects against prolonged inflammation, lung injury, and mortality following systemic insults. 
  • Nervous system defects of AnkyrinB (-/-) mice suggest functional overlap between the cell adhesion molecule L1 and 440-kD AnkyrinB in premyelinated axons. 
  • Neural selective activation and temporal regulation of a mammalian GAP-43 promoter in zebrafish. 
  • Neuronal ceroid lipofuscinosis: a common pathway? 
  • Neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1) as predictors of incident CKD stage 3: the Atherosclerosis Risk in Communities (ARIC) Study. 
  • Nicotinamide adenine dinucleotide (NAD) and its metabolites inhibit T lymphocyte proliferation: role of cell surface NAD glycohydrolase and pyrophosphatase activities. 
  • No association between alleles or genotypes at the dopamine transporter gene and schizophrenia. 
  • No association between polymorphisms in the serotonin transporter gene and susceptibility to cocaine dependence among African-American individuals. 
  • No major role of common SV2A variation for predisposition or levetiracetam response in epilepsy. 
  • Nociceptors are interleukin-1beta sensors. 
  • Novel inhibitory action of tunicamycin homologues suggests a role for dynamic protein fatty acylation in growth cone-mediated neurite extension. 
  • Nuclear factor-kappaB mediates Kupffer cell apoptosis through transcriptional activation of Fas/FasL. 
  • Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation. 
  • Oligomerization and trafficking of the human dopamine transporter. Mutational analysis identifies critical domains important for the functional expression of the transporter. 
  • On the TRAIL from p53 to apoptosis? 
  • Optimization of the sequence of antigen loading and CD40-ligand-induced maturation of dendritic cells. 
  • Orphan transporter SLC6A18 is renal neutral amino acid transporter B0AT3. 
  • Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. 
  • Overexpression of a Drosophila homolog of apolipoprotein D leads to increased stress resistance and extended lifespan. 
  • Overexpression of folate binding protein and mesothelin are associated with uterine serous carcinoma. 
  • P-selectin glycoprotein ligand-1 is broadly expressed in cells of myeloid, lymphoid, and dendritic lineage and in some nonhematopoietic cells. 
  • PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis. 
  • PIG-A, DAF and proto-oncogene expression in paroxysmal nocturnal haemoglobinuria-associated acute myelogenous leukaemia blasts. 
  • Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor. 
  • Passively transferred antibodies directed against conserved regions of SIV envelope protect macaques from SIV infection. 
  • Perforin knockout mice, but not mice with MAIDS, show protection against experimental cytomegalovirus retinitis after adoptive transfer of immune cells with a functional perforin cytotoxic pathway. 
  • Performance of kidney injury molecule-1 and liver fatty acid-binding protein and combined biomarkers of AKI after cardiac surgery. 
  • Peripheral nerve and neuromuscular junction pathology in Pompe disease. 
  • Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance. 
  • Phase 1 study in patients with metastatic melanoma of immunization with dendritic cells presenting epitopes derived from the melanoma-associated antigens MART-1 and gp100. 
  • Phase 2 study of the g209-2M melanoma peptide vaccine and low-dose interleukin-2 in advanced melanoma: Cancer and Leukemia Group B 509901. 
  • Phenotypic characterization and ontogeny of mesodermal-derived and endocrine epithelial components of the human thymic microenvironment. 
  • Physiopathologic role of cubilin and megalin. 
  • Plasma membrane monoamine transporters: structure, regulation and function. 
  • Plasma membrane transporters of serotonin, dopamine, and norepinephrine mediate serotonin accumulation in atypical locations in the developing brain of monoamine oxidase A knock-outs. 
  • Plasmacytoid dendritic cells in inflamed muscle of patients with juvenile dermatomyositis. 
  • Plexin D1 determines body fat distribution by regulating the type V collagen microenvironment in visceral adipose tissue. 
  • Plexin-B2 and Plexin-D1 in dendritic cells: expression and IL-12/IL-23p40 production. 
  • Plexin-D1 is a novel regulator of germinal centers and humoral immune responses. 
  • Polyclonal long-term MFGS-gp91phox marking in rhesus macaques after nonmyeloablative transplantation with transduced autologous peripheral blood progenitor cells. 
  • Polymorphisms of the FAS and FAS ligand genes associated with risk of cutaneous malignant melanoma. 
  • Porcine endothelial cell membrane antigens recognized by human and baboon xenoreactive antibodies during organ perfusion. 
  • Postnatal TrkB ablation in corticolimbic interneurons induces social dominance in male mice. 
  • Potent selection of antigen loss variants of B16 melanoma following inflammatory killing of melanocytes in vivo. 
  • Poxvirus tumor necrosis factor receptor (TNFR)-like T2 proteins contain a conserved preligand assembly domain that inhibits cellular TNFR1-induced cell death. 
  • Pramipexole vs levodopa as initial treatment for Parkinson disease: A randomized controlled trial. Parkinson Study Group. 
  • Predicting treatment-outcome in cocaine dependence from admission urine drug screen and peripheral serotonergic measures. 
  • Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis. 
  • Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out mice: differential effects of D1 and D2 receptor antagonists. 
  • Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin. 
  • Prevention of acute lung injury in swine: depletion of pulmonary intravascular macrophages using liposomal clodronate. 
  • Probing the interaction of the multidrug-resistance phenotype with the polypeptide ionophore gramicidin D via functional channel formation. 
  • Profound neuronal plasticity in response to inactivation of the dopamine transporter. 
  • Programming of brainstem serotonin transporter development by prenatal glucocorticoids. 
  • Properties of procoagulant platelets: defining and characterizing the subpopulation binding a functional prothrombinase. 
  • Prostate stem cell antigen is a promising candidate for immunotherapy of advanced prostate cancer. 
  • Protein glycosylation as an adaptive response in Archaea: growth at different salt concentrations leads to alterations in Haloferax volcanii S-layer glycoprotein N-glycosylation. 
  • Protein kinase A operates a molecular switch that governs yeast pseudohyphal differentiation. 
  • Protein kinase C activity, translocation, and conventional isoforms in aging rat brain. 
  • Protein profile of exosomes from trabecular meshwork cells. 
  • Purified lymphocyte function-associated antigen-3 (LFA-3) activates human thymocytes via the CD2 pathway. 
  • RANK, RANKL, OPG, and M-CSF expression in stromal cells during corneal wound healing. 
  • RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells. 
  • Rapid Development of gp120-Focused Neutralizing B Cell Responses during Acute Simian Immunodeficiency Virus Infection of African Green Monkeys. 
  • Rapid dendritic transport of TGN38, a putative cargo receptor. 
  • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. 
  • Re-evaluation of the role of the dopamine transporter in dopamine system homeostasis. 
  • Re-examination of CD91 function in GRP94 (glycoprotein 96) surface binding, uptake, and peptide cross-presentation. 
  • Recombinant anti-podoplanin (NZ-1) immunotoxin for the treatment of malignant brain tumors. 
  • Recombinant modified vaccinia virus ankara expressing the surface gp120 of simian immunodeficiency virus (SIV) primes for a rapid neutralizing antibody response to SIV infection in macaques. 
  • Redundancy renders the glycoprotein 96 receptor scavenger receptor A dispensable for cross priming in vivo. 
  • Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye. 
  • Regulation of TCRβ allelic exclusion by gene segment proximity and accessibility. 
  • Regulation of adenylyl cyclase-coupled beta-adrenergic receptors. 
  • Relationship between serotonin transporter gene polymorphisms and platelet serotonin transporter sites among African-American cocaine-dependent individuals and healthy volunteers. 
  • Relationship of a 5-HT transporter functional polymorphism to 5-HT1A receptor binding in healthy women. 
  • Release of endogenous danger signals from HIFU-treated tumor cells and their stimulatory effects on APCs. 
  • Repression of B7.2 on self-reactive B cells is essential to prevent proliferation and allow Fas-mediated deletion by CD4(+) T cells. 
  • Requirement for reactive oxygen species in serum-induced and platelet-derived growth factor-induced growth of airway smooth muscle. 
  • Retrovirally transduced human dendritic cells can generate T cells recognizing multiple MHC class I and class II epitopes from the melanoma antigen glycoprotein 100. 
  • Role of JAK3 in CD40-mediated signaling. 
  • Role of calcium in the activation of erp72 and heme oxygenase-1 expression on depletion of endoplasmic reticulum calcium stores in rat neuronal cell culture. 
  • Role of dopamine transporter in methamphetamine-induced neurotoxicity: evidence from mice lacking the transporter. 
  • Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. 
  • SAMP14, a novel, acrosomal membrane-associated, glycosylphosphatidylinositol-anchored member of the Ly-6/urokinase-type plasminogen activator receptor superfamily with a role in sperm-egg interaction. 
  • STIM1 enhances SR Ca2+ content through binding phospholamban in rat ventricular myocytes. 
  • STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle. 
  • STIM1-Ca(2+) signaling is required for the hypertrophic growth of skeletal muscle in mice. 
  • Seasonal variations in the binding of [3H]paroxetine to the platelet serotonin transporter sites in African-American cocaine-dependent patients and healthy volunteers. 
  • Segmental distribution of the endocytosis receptor gp330 in renal proximal tubules. 
  • Select de novo gene and protein expression during renal epithelial cell culture in rotating wall vessels is shear stress dependent. 
  • Selective conservation of GAP-43 structure in vertebrate evolution. 
  • Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha. 
  • Sequence requirements for ligand binding and cell surface expression of the Tac antigen, a human interleukin-2 receptor. 
  • Sequential delivery of maturation stimuli increases human dendritic cell IL-12 production and enhances tumor antigen-specific immunogenicity. 
  • Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periods. 
  • Serotonin transporter expression in rat brain regions and blood platelets: aging and glucocorticoid effects. 
  • Serotonin transporter gene polymorphism and antidepressant response. 
  • Serotonin transporter genetic variation and the response of the human amygdala. 
  • Serotonin transporter polymorphisms and measures of impulsivity, aggression, and sensation seeking among African-American cocaine-dependent individuals. 
  • Serotonin-related gene polymorphisms and central nervous system serotonin function. 
  • Signal sequence- and translation-independent mRNA localization to the endoplasmic reticulum. 
  • Signal transduction cascades regulating pseudohyphal differentiation of Saccharomyces cerevisiae. 
  • Simian immunodeficiency virus (SIV) envelope-specific Fabs with high-level homologous neutralizing activity: recovery from a long-term-nonprogressor SIV-infected macaque. 
  • Socking It to cardiac hypertrophy: STIM1-mediated Ca2+ entry in the cardiomyocyte. 
  • Sok2 regulates yeast pseudohyphal differentiation via a transcription factor cascade that regulates cell-cell adhesion. 
  • Soluble L-selectin is present in human plasma at high levels and retains functional activity. 
  • Soluble monomeric P-selectin containing only the lectin and epidermal growth factor domains binds to P-selectin glycoprotein ligand-1 on leukocytes. 
  • Spectrum of mutations in the Batten disease gene, CLN3. 
  • Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. 
  • Static and dynamic lengths of neutrophil microvilli. 
  • Stevens-Johnson syndrome induced by the cross-reactivity between teicoplanin and vancomycin. 
  • Stimulation of macrophages and neutrophils by complexes of lipopolysaccharide and soluble CD14. 
  • Strategy for elucidating differentially expressed genes in leiomyomata identified by microarray technology. 
  • Stretch-regulated exocytosis/endocytosis in bladder umbrella cells. 
  • Structural requirements for association of neurofascin with ankyrin. 
  • Structural requirements regulate endoproteolytic release of the L-selectin (CD62L) adhesion receptor from the cell surface of leukocytes. 
  • Structure and expression of a membrane component of the inhibin receptor system. 
  • Structure of human Niemann-Pick C1 protein. 
  • Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein. 
  • Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. 
  • Subsets of murine lung fibroblasts express membrane-bound and soluble IL-4 receptors. Role of IL-4 in enhancing fibroblast proliferation and collagen synthesis. 
  • Surface hydrophobicity changes of two Candida albicans serotype B mnn4delta mutants. 
  • Sustained Adrenergic Signaling Promotes Intratumoral Innervation through BDNF Induction. 
  • Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells. 
  • Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds. 
  • Synergistic role of HSP90α and HSP90β to promote myofibroblast persistence in lung fibrosis. 
  • Synovial microenvironment-T cell interactions. Human T cells bind to fibroblast-like synovial cells in vitro. 
  • Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones. 
  • Synthesis and biological evaluation of pentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecane derivatives as potential therapeutic agents in Parkinson's disease. 
  • T cell-mediated elimination of B7.2 transgenic B cells. 
  • TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice. 
  • Targeted overexpression of G protein-coupled receptor kinase-2 in osteoblasts promotes bone loss. 
  • Targeting molecular and cellular inhibitory mechanisms for improvement of antitumor memory responses reactivated by tumor cell vaccine. 
  • Telencephalic neurons monosynaptically link brainstem and forebrain premotor networks necessary for song. 
  • The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen. 
  • The CD19 signal transduction complex of B lymphocytes. Deletion of the CD19 cytoplasmic domain alters signal transduction but not complex formation with TAPA-1 and Leu 13. 
  • The CLN3 gene is a novel molecular target for cancer drug discovery. 
  • The COBRA family of putative GPI-anchored proteins in Arabidopsis. A new fellowship in expansion. 
  • The G protein-coupled receptor gpr1 is a nutrient sensor that regulates pseudohyphal differentiation in Saccharomyces cerevisiae. 
  • The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits. 
  • The Inab phenotype: characterization of the membrane protein and complement regulatory defect. 
  • The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer. 
  • The Lutheran glycoprotein: a multifunctional adhesion receptor. 
  • The NH(2)-terminus of norepinephrine transporter contains a basolateral localization signal for epithelial cells. 
  • The V3 domain of SIVmac251 gp120 contains a linear neutralizing epitope. 
  • The alterations in CNS serotonergic mechanisms caused by neonatal chlorpyrifos exposure are permanent. 
  • The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus. 
  • The cellular and synaptic location of activated TrkB in mouse hippocampus during limbic epileptogenesis. 
  • The cutaneous lymphocyte antigen is an essential component of the L-selectin ligand induced on human vascular endothelial cells. 
  • The dopamine transporter. The cloned target site of parkinsonism-inducing toxins and of drugs of abuse. 
  • The dopamine transporter: a crucial component regulating dopamine transmission. 
  • The erythrocytes in paroxysmal nocturnal haemoglobinuria of intermediate sensitivity to complement lysis. 
  • The future of organ and tissue transplantation: can T-cell costimulatory pathway modifiers revolutionize the prevention of graft rejection? 
  • The genetic architecture of biofilm formation in a clinical isolate of Saccharomyces cerevisiae. 
  • The genetic determinants of smoking. 
  • The human poliovirus receptor. Receptor-virus interaction and parameters of disease specificity. 
  • The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins. 
  • The linker for activation of B cells (LAB)/non-T cell activation linker (NTAL) regulates triggering receptor expressed on myeloid cells (TREM)-2 signaling and macrophage inflammatory responses independently of the linker for activation of T cells. 
  • The mouse Cd83 gene: structure, domain organization, and chromosome localization. 
  • The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity. 
  • The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter. 
  • The perforin-dependent immunological synapse allows T-cell activation-dependent tumor targeting by MLV vector particles. 
  • The promoter of human T-cell leukemia virus type-I is repressed by the immediate-early gene region of human cytomegalovirus in primary blood lymphocytes. 
  • The role of Toll-like receptor 4 in environmental airway injury in mice. 
  • The role of adhesion molecules in epithelial-T-cell interactions in thymus and skin. 
  • The role of innate immunity in acute allograft rejection after lung transplantation. 
  • The role of p65 NF-kappaB/RelA in pancreatitis-induced Kupffer cell apoptosis. 
  • The role of platelet receptors and adhesion molecules in coronary artery disease. 
  • The role of store-operated calcium influx in skeletal muscle signaling. 
  • The selective serotonin-2A receptor antagonist M100907 reverses behavioral deficits in dopamine transporter knockout mice. 
  • The serotonin transporter gene-linked polymorphism and negative emotionality: placing single gene effects in the context of genetic background and environment. 
  • The signal sequence receptor, unlike the signal recognition particle receptor, is not essential for protein translocation. 
  • The tetraspanin CD81 regulates the expression of CD19 during B cell development in a postendoplasmic reticulum compartment. 
  • The transcription factor calcium-response factor limits NMDA receptor-dependent transcription in the developing brain. 
  • The transmembrane hyaluronate receptor (CD44): multiple functions, multiple forms. 
  • Three-dimensional structures of soluble CD4-bound states of trimeric simian immunodeficiency virus envelope glycoproteins determined by using cryo-electron tomography. 
  • Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand. 
  • Thrombospondin as a component of the extracellular matrix of epiretinal membranes: comparisons with cellular fibronectin. 
  • Thymic expression of the transcription factor Nur77 rescues the T cell but not the B cell abnormality of gld/gld mice. 
  • Thymocyte LFA-1 and thymic epithelial cell ICAM-1 molecules mediate binding of activated human thymocytes to thymic epithelial cells. 
  • Tolerance induced by apoptotic antigen-coupled leukocytes is induced by PD-L1+ and IL-10-producing splenic macrophages and maintained by T regulatory cells. 
  • Toll-like receptor 4 (TLR4)-deficient murine macrophage cell line as an in vitro assay system to show TLR4-independent signaling of Bacteroides fragilis lipopolysaccharide. 
  • Toll-like receptor 7 mediates pruritus. 
  • Toll-like receptors and allograft rejection. 
  • Toll-like receptors in the pathogenesis of human disease. 
  • Topology of cell adhesion molecules. 
  • Transcription factor NF-kappaB regulates inducible CD83 gene expression in activated T lymphocytes. 
  • Transethnic genome-wide scan identifies novel Alzheimer's disease loci. 
  • Transgenic expression of the viral FLIP MC159 causes lpr/gld-like lymphoproliferation and autoimmunity. 
  • Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. 
  • Transient subversion of CD40 ligand function diminishes immune responses to adenovirus vectors in mouse liver and lung tissues. 
  • Translation of an integral membrane protein in distal dendrites of hippocampal neurons. 
  • Treatment of steroid-refractory acute graft-versus-host disease with anti-CD147 monoclonal antibody ABX-CBL. 
  • Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. 
  • Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. 
  • Two Golgi integral membrane proteins (GIMPS) exhibit region- and cell type-specific distribution in the epididymis of the adult rat. 
  • Two distinct N-glycosylation pathways process the Haloferax volcanii S-layer glycoprotein upon changes in environmental salinity. 
  • Unmasking Proteolytic Activity for Adult Visual Cortex Plasticity by the Removal of Lynx1. 
  • Unmasking the osteoinductive effects of a G-protein-coupled receptor (GPCR) kinase (GRK) inhibitor by treatment with PTH(1-34). 
  • Uptake and release of norepinephrine by serotonergic terminals in norepinephrine transporter knock-out mice: implications for the action of selective serotonin reuptake inhibitors. 
  • Utilizing quantitative polymerase chain reaction to evaluate prostate stem cell antigen as a tumor marker in pancreatic cancer. 
  • VNTR polymorphism for the human dopamine transporter gene (DAT1). 
  • VSV-G pseudotyped, MuLV-based, semi-replication-competent retrovirus for cancer treatment. 
  • Variation of human amygdala response during threatening stimuli as a function of 5'HTTLPR genotype and personality style. 
  • Viral and bacterial infections induce expression of multiple NK cell receptors in responding CD8(+) T cells. 
  • Viral infection abrogates CD8(+) T-cell deletion induced by costimulation blockade. 
  • Visualization of P-selectin glycoprotein ligand-1 as a highly extended molecule and mapping of protein epitopes for monoclonal antibodies. 
  • Visualization of carbohydrate-binding molecules expressed by myelomono- and erythropoietic cells derived from human bone marrow: an immunoenzymatic double-staining study. 
  • Wild Mandrillus sphinx are carriers of two types of lentivirus. 
  • Wnt signaling: an embarrassment of receptors. 
  • X-linked inhibitor of apoptosis protein inhibition induces apoptosis and enhances chemotherapy sensitivity in human prostate cancer cells. 
  • YSPSL (rPSGL-Ig) for improvement of early renal allograft function: a double-blind, placebo-controlled, multi-center Phase IIa study. 
  • ZAP-70 tyrosine kinase is required for the up-regulation of Fas ligand in activation-induced T cell apoptosis. 
  • [Behavioral, cellular and molecular consequences of the dopamine transporter gene inactivation]. 
  • [Endocytosis and receptors: molecular and physiological aspects]. 
  • [Pharmacological modulation of dopaminergic transmission in the rat striatum in vivo]. 
  • [Serotonin transporter gene polymorphism and factors influencing mental and physical health in aging]. 
  • [Vesicular flow in epithelial cells: physiopathologic importance of two multiligand receptors]. 
  • hBRAG, a novel B cell lineage cDNA encoding a type II transmembrane glycoprotein potentially involved in the regulation of recombination activating gene 1 (RAG1). 
• 

  Keywords of People

  • Bejsovec, Amy, Associate Professor of Biology, Biology
  • Bennett, Vann, George B. Geller Distinguished Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Buckley, Rebecca Hatcher, James Buren Sidbury Distinguished Professor of Pediatrics, in the School of Medicine, Immunology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor of Cell Biology, Biomedical Engineering
  • Ferrari, Guido, Associate Professor of Surgery, Molecular Genetics and Microbiology
  • Guan, Ziqiang, Research Professor in Biochemistry, Biochemistry
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma