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Subject Areas on Research
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A Fringe-modified Notch signal affects specification of mesoderm and endoderm in the sea urchin embryo.
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A contractile actomyosin network linked to adherens junctions by Canoe/afadin helps drive convergent extension.
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A genomic regulatory network for development.
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A high throughput screen identifies Nefopam as targeting cell proliferation in β-catenin driven neoplastic and reactive fibroproliferative disorders.
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A high-resolution anatomical ontology of the developing murine genitourinary tract.
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A mechanism for gene-environment interaction in the etiology of congenital scoliosis.
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A micromere induction signal is activated by beta-catenin and acts through notch to initiate specification of secondary mesenchyme cells in the sea urchin embryo.
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A new Cre driver mouse line, Tcf21/Pod1-Cre, targets metanephric mesenchyme.
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A provisional regulatory gene network for specification of endomesoderm in the sea urchin embryo.
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Aberrant expression of cell-cycle regulatory proteins in human mesenchymal neoplasia.
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Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway.
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Activation of pmar1 controls specification of micromeres in the sea urchin embryo.
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Adult-derived stem cells and their potential for use in tissue repair and molecular medicine.
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Alternative inclusion of fibroblast growth factor receptor 2 exon IIIc in Dunning prostate tumors reveals unexpected epithelial mesenchymal plasticity.
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An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart.
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An FGF-WNT gene regulatory network controls lung mesenchyme development.
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Archenteron precursor cells can organize secondary axial structures in the sea urchin embryo.
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Atypical hemifacial microsomia associated with Chiari I malformation and syrinx: further evidence indicating that chiari I malformation is a disorder of the paraaxial mesoderm. Case report and review of the literature.
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Axenfeld-Rieger syndrome. A spectrum of developmental disorders.
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BMP antagonism is required in both the node and lateral plate mesoderm for mammalian left-right axis establishment.
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BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites.
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BMP-2 and BMP-9 promotes chondrogenic differentiation of human multipotential mesenchymal cells and overcomes the inhibitory effect of IL-1.
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BMP4 is essential for lens induction in the mouse embryo.
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Blocking Dishevelled signaling in the noncanonical Wnt pathway in sea urchins disrupts endoderm formation and spiculogenesis, but not secondary mesoderm formation.
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Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development.
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Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis.
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Bmp4 is required for the generation of primordial germ cells in the mouse embryo.
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Bone morphogenetic protein 4 in the extraembryonic mesoderm is required for allantois development and the localization and survival of primordial germ cells in the mouse.
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Bone morphogenetic protein-4 (BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos.
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Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.
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Bone morphogenetic proteins induce pancreatic cancer cell invasiveness through a Smad1-dependent mechanism that involves matrix metalloproteinase-2.
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Branching morphogenesis of the lung: new models for a classical problem.
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Cadherin-11 expressed in association with mesenchymal morphogenesis in the head, somite, and limb bud of early mouse embryos.
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Cell-cell interactions regulate skeleton formation in the sea urchin embryo.
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Centrifugal migration of mesenchymal cells in embryonic lung.
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Changes in the pattern of adherens junction-associated beta-catenin accompany morphogenesis in the sea urchin embryo.
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Characterization of the role of cadherin in regulating cell adhesion during sea urchin development.
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Comparative proteomic analysis of cell cycle-dependent apoptosis induced by transforming growth factor-beta.
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Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo.
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Complex choristoma of the gyrus rectus: a distinct clinicopathologic entity?
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Conditional specification of endomesoderm.
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Contribution of hedgehog signaling to the establishment of left-right asymmetry in the sea urchin.
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DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction.
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Delayed transition to new cell fates during cellular reprogramming.
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Developmental defects in mouse embryos lacking N-cadherin.
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Developmental single-cell transcriptomics in the Lytechinus variegatus sea urchin embryo.
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Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo.
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Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm.
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Distinct requirements for extra-embryonic and embryonic bone morphogenetic protein 4 in the formation of the node and primitive streak and coordination of left-right asymmetry in the mouse.
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Divergent gene regulation and growth effects by NF-kappa B in epithelial and mesenchymal cells of human skin.
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Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled.
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Dynamics of Delta/Notch signaling on endomesoderm segregation in the sea urchin embryo.
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Dynamics of thin filopodia during sea urchin gastrulation.
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Early inductive interactions are involved in restricting cell fates of mesomeres in sea urchin embryos.
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Ectoderm cell--ECM interaction is essential for sea urchin embryo skeletogenesis.
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Embryo dissociation, cell isolation, and cell reassociation.
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Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis.
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Endothelial SUR-8 acts in an ERK-independent pathway during atrioventricular cushion development.
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Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: a novel cell-mediated gene therapy.
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Epidermal growth factor alters metabolism of inositol lipids and activity of protein kinase C in mouse embryo palate mesenchyme cells.
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Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression.
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Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer.
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Epithelial-mesenchymal transitions and hepatocarcinogenesis.
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Epithelial-to-mesenchymal transitions in the liver.
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Epithelial/mesenchymal interactions and branching morphogenesis of the lung.
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Epstein-Barr virus-associated epithelial and mesenchymal neoplasms.
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Epstein-Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients.
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Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis.
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Expression of heterogeneous nuclear ribonucleoprotein A2/B1 changes with critical stages of mammalian lung development.
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FGF signals guide migration of mesenchymal cells, control skeletal morphogenesis [corrected] and regulate gastrulation during sea urchin development.
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Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers.
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Ferritin heavy chain-mediated iron homeostasis and subsequent increased reactive oxygen species production are essential for epithelial-mesenchymal transition.
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Fgf8 is required for anterior heart field development.
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Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung.
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Fibroblast growth factor signaling in the developing tracheoesophageal fistula.
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Frizzled5/8 is required in secondary mesenchyme cells to initiate archenteron invagination during sea urchin development.
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HES1 is a novel downstream modifier of the SHH-GLI3 Axis in the development of preaxial polydactyly.
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HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer.
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Hand2 regulates extracellular matrix remodeling essential for gut-looping morphogenesis in zebrafish.
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Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4.
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Hedgehog signaling patterns mesoderm in the sea urchin.
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Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans.
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Hedgehog-mediated mesenchymal-epithelial interactions modulate hepatic response to bile duct ligation.
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Identification and localization of a sea urchin Notch homologue: insights into vegetal plate regionalization and Notch receptor regulation.
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Identification of Tgf beta1i4 as a downstream target of Foxc1.
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In vitro growth and phenotypic characterization of mesodermal-derived and epithelial components of normal and abnormal human thymus.
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Indian hedgehog as a progesterone-responsive factor mediating epithelial-mesenchymal interactions in the mouse uterus.
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Induction of lef1 during zebrafish fin regeneration.
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Ingression of primary mesenchyme cells of the sea urchin embryo: a precisely timed epithelial mesenchymal transition
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Inhibitors of metalloendoproteases block spiculogenesis in sea urchin primary mesenchyme cells.
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Intercellular growth factor signaling and the development of mouse tracheal submucosal glands.
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Intracardiac septation requires hedgehog-dependent cellular contributions from outside the heart.
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Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse.
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Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis.
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J. P. Hill and Katherine Watson's studies of the neural crest in marsupials.
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LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development.
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Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway.
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Loss of type III transforming growth factor beta receptor expression increases motility and invasiveness associated with epithelial to mesenchymal transition during pancreatic cancer progression.
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LvGroucho and nuclear beta-catenin functionally compete for Tcf binding to influence activation of the endomesoderm gene regulatory network in the sea urchin embryo.
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LvNotch signaling mediates secondary mesenchyme specification in the sea urchin embryo.
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LvNumb works synergistically with Notch signaling to specify non-skeletal mesoderm cells in the sea urchin embryo.
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Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype.
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Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts.
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Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development.
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Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis.
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Morphogenesis.
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Mouse Mesenchyme forkhead 2 (Mf2): expression, DNA binding and induction by sonic hedgehog during somitogenesis.
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Multiple roles for Sox2 in the developing and adult mouse trachea.
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NIEHS/EPA Workshops. Cellular migration.
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Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation.
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Novel origins of lineage founder cells in the direct-developing sea urchin Heliocidaris erythrogramma.
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Nuclear beta-catenin is required to specify vegetal cell fates in the sea urchin embryo.
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Nuclear beta-catenin-dependent Wnt8 signaling in vegetal cells of the early sea urchin embryo regulates gastrulation and differentiation of endoderm and mesodermal cell lineages.
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Ontogenesis of prolactin receptors in the human fetus in early gestation. Implications for tissue differentiation and development.
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Pattern formation during gastrulation in the sea urchin embryo.
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Pattern of serum protein gene expression in mouse visceral yolk sac and foetal liver.
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Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development.
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Perspective on Epithelial-Mesenchymal Transitions in Embryos.
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Phenotypic characterization and ontogeny of mesodermal-derived and endocrine epithelial components of the human thymic microenvironment.
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Primary mesenchyme cell patterning during the early stages following ingression.
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Pulmonary fibrosis: patterns and perpetrators.
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RYK-mediated filopodial pathfinding facilitates midgut elongation.
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Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function.
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Repression of mesodermal fate by foxa, a key endoderm regulator of the sea urchin embryo.
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Reprint of: Conditional specification of endomesoderm.
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Requirement of HDAC6 for transforming growth factor-beta1-induced epithelial-mesenchymal transition.
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Retinoic acid receptor alpha function in vertebrate limb skeletogenesis: a modulator of chondrogenesis.
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Rhabdomyomatous mesenchymal hamartoma presenting as a sacral skin tag in two neonates with spinal dysraphism.
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Role for ETS domain transcription factors Pea3/Erm in mouse lung development.
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Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men.
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Roles for Fgf signaling during zebrafish fin regeneration.
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SHP-2 is required for the maintenance of cardiac progenitors.
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SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site.
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STRIP1, a core component of STRIPAK complexes, is essential for normal mesoderm migration in the mouse embryo.
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Sclero-cornea and defective mesodermal migration.
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Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair.
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Sequence and expression of zebrafish foxc1a and foxc1b, encoding conserved forkhead/winged helix transcription factors.
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Sequential expression of germ-layer specific molecules in the sea urchin embryo.
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Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla.
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Skeletal pattern is specified autonomously by the primary mesenchyme cells in sea urchin embryos.
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Skin-derived precursors differentiate into skeletogenic cell types and contribute to bone repair.
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Smad5 induces ventral fates in Xenopus embryo.
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Sonic hedgehog from pharyngeal arch 1 epithelium is necessary for early mandibular arch cell survival and later cartilage condensation differentiation.
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SpHnf6, a transcription factor that executes multiple functions in sea urchin embryogenesis.
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Spatially restricted patterns of expression of the homeobox-containing gene Hox 2.1. during mouse embryogenesis.
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Specification of chondrocytes and cartilage tissues from embryonic stem cells.
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Specification of endoderm and mesoderm in the sea urchin.
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Syntaxin 1A is transiently expressed in fetal lung mesenchymal cells: potential developmental roles.
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TBX3 Directs Cell-Fate Decision toward Mesendoderm.
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Target recognition by the archenteron during sea urchin gastrulation.
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Telomere dysfunction causes alveolar stem cell failure.
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Temporal mechanisms of myogenic specification in human induced pluripotent stem cells.
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The DVR gene family in embryonic development.
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The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction.
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The Role of Brachyruy (T) During Gastrulations Movement in the Sea Urchin, Lytechinus variegatus
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The Snail repressor is required for PMC ingression in the sea urchin embryo.
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The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development.
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The control of foxN2/3 expression in sea urchin embryos and its function in the skeletogenic gene regulatory network.
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The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate.
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The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus.
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The mammalian class 3 PI3K (PIK3C3) is required for early embryogenesis and cell proliferation.
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The organizer factors Chordin and Noggin are required for mouse forebrain development.
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The origin of spicule-forming cells in a 'primitive' sea urchin (Eucidaris tribuloides) which appears to lack primary mesenchyme cells.
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The regulation of primary mesenchyme cell migration in the sea urchin embryo: transplantations of cells and latex beads.
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The role of the forkhead transcription factor, Foxc1, in the development of the mouse lacrimal gland.
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The role of thin filopodia in motility and morphogenesis.
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The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo.
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Tissue interactions and estrogenic response during human female fetal reproductive tract development.
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Tissue interactions pattern the mesenchyme of the embryonic mouse lung.
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Transcription Factor 21 Is Required for Branching Morphogenesis and Regulates the Gdnf-Axis in Kidney Development.
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Two embryonic, tissue-specific molecules identified by a double-label immunofluorescence technique for monoclonal antibodies.
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UG4 enhancer-driven GATA-2 and bone morphogenetic protein 4 complementation remedies the CAKUT phenotype in Gata2 hypomorphic mutant mice.
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Vascular-mesenchymal cross-talk through Vegf and Pdgf drives organ patterning.
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Wnt2 coordinates the commitment of mesoderm to hematopoietic, endothelial, and cardiac lineages in embryoid bodies.
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Zebrafish second heart field development relies on progenitor specification in anterior lateral plate mesoderm and nkx2.5 function.
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alphaSU2, an epithelial integrin that binds laminin in the sea urchin embryo.
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beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds.
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p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis.
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Keywords of People
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Abbruzzese, James,
D. C. I. Distinguished Professor of Medical Oncology,
Medicine, Medical Oncology
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Choi, Steven Sok,
Associate Professor of Medicine,
Medicine, Gastroenterology
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Hilton, Matthew James,
Associate Professor in Orthopaedic Surgery,
Cell Biology
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Hogan, Brigid L. M.,
Research Professor of Cell Biology,
Cell Biology
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McCall, Shannon Jones,
Associate Professor of Pathology,
Pathology
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Wray, Gregory Allan,
Professor of Biology,
Evolutionary Anthropology