Mesoderm

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  Subject Areas on Research

  • A Fringe-modified Notch signal affects specification of mesoderm and endoderm in the sea urchin embryo. 
  • A caudal proliferating growth center contributes to both poles of the forming heart tube. 
  • A contractile actomyosin network linked to adherens junctions by Canoe/afadin helps drive convergent extension. 
  • A genomic regulatory network for development. 
  • A high throughput screen identifies Nefopam as targeting cell proliferation in β-catenin driven neoplastic and reactive fibroproliferative disorders. 
  • A high-resolution anatomical ontology of the developing murine genitourinary tract. 
  • A mechanism for gene-environment interaction in the etiology of congenital scoliosis. 
  • A micromere induction signal is activated by beta-catenin and acts through notch to initiate specification of secondary mesenchyme cells in the sea urchin embryo. 
  • A new Cre driver mouse line, Tcf21/Pod1-Cre, targets metanephric mesenchyme. 
  • A provisional regulatory gene network for specification of endomesoderm in the sea urchin embryo. 
  • A stem structure in fibroblast growth factor receptor 2 transcripts mediates cell-type-specific splicing by approximating intronic control elements. 
  • Aberrant expression of cell-cycle regulatory proteins in human mesenchymal neoplasia. 
  • Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway. 
  • Activation of pmar1 controls specification of micromeres in the sea urchin embryo. 
  • Addition of the BMP4 antagonist, noggin, disrupts avian inner ear development. 
  • Adult-derived stem cells and their potential for use in tissue repair and molecular medicine. 
  • Alteration of early vascular development after ablation of cranial neural crest. 
  • Alternative inclusion of fibroblast growth factor receptor 2 exon IIIc in Dunning prostate tumors reveals unexpected epithelial mesenchymal plasticity. 
  • An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart. 
  • An FGF-WNT gene regulatory network controls lung mesenchyme development. 
  • Archenteron precursor cells can organize secondary axial structures in the sea urchin embryo. 
  • Atypical hemifacial microsomia associated with Chiari I malformation and syrinx: further evidence indicating that chiari I malformation is a disorder of the paraaxial mesoderm. Case report and review of the literature. 
  • Axenfeld-Rieger syndrome. A spectrum of developmental disorders. 
  • BMP antagonism is required in both the node and lateral plate mesoderm for mammalian left-right axis establishment. 
  • BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites. 
  • BMP-2 and BMP-9 promotes chondrogenic differentiation of human multipotential mesenchymal cells and overcomes the inhibitory effect of IL-1. 
  • BMP4 is essential for lens induction in the mouse embryo. 
  • Blocking Dishevelled signaling in the noncanonical Wnt pathway in sea urchins disrupts endoderm formation and spiculogenesis, but not secondary mesoderm formation. 
  • Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development. 
  • Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis. 
  • Bmp4 is required for the generation of primordial germ cells in the mouse embryo. 
  • Bone morphogenetic protein 4 in the extraembryonic mesoderm is required for allantois development and the localization and survival of primordial germ cells in the mouse. 
  • Bone morphogenetic protein-4 (BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos. 
  • Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. 
  • Bone morphogenetic proteins induce pancreatic cancer cell invasiveness through a Smad1-dependent mechanism that involves matrix metalloproteinase-2. 
  • Branching morphogenesis of the lung: new models for a classical problem. 
  • Cadherin-11 expressed in association with mesenchymal morphogenesis in the head, somite, and limb bud of early mouse embryos. 
  • Cell-cell interactions regulate skeleton formation in the sea urchin embryo. 
  • Centrifugal migration of mesenchymal cells in embryonic lung. 
  • Changes in the pattern of adherens junction-associated beta-catenin accompany morphogenesis in the sea urchin embryo. 
  • Characterization of the role of cadherin in regulating cell adhesion during sea urchin development. 
  • Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo. 
  • Complex choristoma of the gyrus rectus: a distinct clinicopathologic entity? 
  • Contribution of hedgehog signaling to the establishment of left-right asymmetry in the sea urchin. 
  • DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction. 
  • Delayed transition to new cell fates during cellular reprogramming. 
  • Developmental defects in mouse embryos lacking N-cadherin. 
  • Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. 
  • Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm. 
  • Distinct requirements for extra-embryonic and embryonic bone morphogenetic protein 4 in the formation of the node and primitive streak and coordination of left-right asymmetry in the mouse. 
  • Divergent gene regulation and growth effects by NF-kappa B in epithelial and mesenchymal cells of human skin. 
  • Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled. 
  • Dunning rat prostate adenocarcinomas and alternative splicing reporters: powerful tools to study epithelial plasticity in prostate tumors in vivo. 
  • Dynamics of Delta/Notch signaling on endomesoderm segregation in the sea urchin embryo. 
  • Dynamics of thin filopodia during sea urchin gastrulation. 
  • Early inductive interactions are involved in restricting cell fates of mesomeres in sea urchin embryos. 
  • Ectoderm cell--ECM interaction is essential for sea urchin embryo skeletogenesis. 
  • Embryo dissociation, cell isolation, and cell reassociation. 
  • Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis. 
  • Endothelial SUR-8 acts in an ERK-independent pathway during atrioventricular cushion development. 
  • Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: a novel cell-mediated gene therapy. 
  • Epidermal growth factor alters metabolism of inositol lipids and activity of protein kinase C in mouse embryo palate mesenchyme cells. 
  • Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression. 
  • Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer. 
  • Epithelial-mesenchymal interactions in the alteration of gene expression and morphology following lung injury. 
  • Epithelial-mesenchymal transitions and hepatocarcinogenesis. 
  • Epithelial-to-mesenchymal transitions in the liver. 
  • Epithelial/mesenchymal interactions and branching morphogenesis of the lung. 
  • Epstein-Barr virus-associated epithelial and mesenchymal neoplasms. 
  • Epstein-Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients. 
  • Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis. 
  • Expression of ZIC genes in the development of the chick inner ear and nervous system. 
  • Expression of heterogeneous nuclear ribonucleoprotein A2/B1 changes with critical stages of mammalian lung development. 
  • FGF signals guide migration of mesenchymal cells, control skeletal morphogenesis [corrected] and regulate gastrulation during sea urchin development. 
  • FGF8 signaling is chemotactic for cardiac neural crest cells. 
  • Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers. 
  • Fgf8 is required for anterior heart field development. 
  • Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung. 
  • Fibroblast growth factor signaling in the developing tracheoesophageal fistula. 
  • Fox-2 mediates epithelial cell-specific fibroblast growth factor receptor 2 exon choice. 
  • Frizzled5/8 is required in secondary mesenchyme cells to initiate archenteron invagination during sea urchin development. 
  • GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. 
  • Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition. 
  • Hand2 regulates extracellular matrix remodeling essential for gut-looping morphogenesis in zebrafish. 
  • Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4. 
  • Hedgehog signaling patterns mesoderm in the sea urchin. 
  • Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. 
  • Hedgehog-mediated mesenchymal-epithelial interactions modulate hepatic response to bile duct ligation. 
  • Identification and localization of a sea urchin Notch homologue: insights into vegetal plate regionalization and Notch receptor regulation. 
  • Identification of Tgf beta1i4 as a downstream target of Foxc1. 
  • Identification of an intronic splicing enhancer essential for the inclusion of FGFR2 exon IIIc. 
  • In vitro growth and phenotypic characterization of mesodermal-derived and epithelial components of normal and abnormal human thymus. 
  • Indian hedgehog as a progesterone-responsive factor mediating epithelial-mesenchymal interactions in the mouse uterus. 
  • Induction of lef1 during zebrafish fin regeneration. 
  • Ingression of primary mesenchyme cells of the sea urchin embryo: a precisely timed epithelial mesenchymal transition. 
  • Inhibitors of metalloendoproteases block spiculogenesis in sea urchin primary mesenchyme cells. 
  • Intercellular growth factor signaling and the development of mouse tracheal submucosal glands. 
  • Intracardiac septation requires hedgehog-dependent cellular contributions from outside the heart. 
  • Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse. 
  • Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis. 
  • LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. 
  • Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway. 
  • Loss of type III transforming growth factor beta receptor expression increases motility and invasiveness associated with epithelial to mesenchymal transition during pancreatic cancer progression. 
  • Lrp4 regulates initiation of ureteric budding and is crucial for kidney formation--a mouse model for Cenani-Lenz syndrome. 
  • LvGroucho and nuclear beta-catenin functionally compete for Tcf binding to influence activation of the endomesoderm gene regulatory network in the sea urchin embryo. 
  • LvNotch signaling mediates secondary mesenchyme specification in the sea urchin embryo. 
  • LvNumb works synergistically with Notch signaling to specify non-skeletal mesoderm cells in the sea urchin embryo. 
  • Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype. 
  • Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. 
  • Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development. 
  • Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis. 
  • Morphogenesis. 
  • Mouse Mesenchyme forkhead 2 (Mf2): expression, DNA binding and induction by sonic hedgehog during somitogenesis. 
  • Multiple roles for Sox2 in the developing and adult mouse trachea. 
  • NIEHS/EPA Workshops. Cellular migration. 
  • Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation. 
  • Novel origins of lineage founder cells in the direct-developing sea urchin Heliocidaris erythrogramma. 
  • Nuclear beta-catenin is required to specify vegetal cell fates in the sea urchin embryo. 
  • Nuclear beta-catenin-dependent Wnt8 signaling in vegetal cells of the early sea urchin embryo regulates gastrulation and differentiation of endoderm and mesodermal cell lineages. 
  • Ontogenesis of prolactin receptors in the human fetus in early gestation. Implications for tissue differentiation and development. 
  • Pattern formation during gastrulation in the sea urchin embryo. 
  • Pattern of serum protein gene expression in mouse visceral yolk sac and foetal liver. 
  • Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development. 
  • Phenotypic characterization and ontogeny of mesodermal-derived and endocrine epithelial components of the human thymic microenvironment. 
  • Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1. 
  • Primary mesenchyme cell patterning during the early stages following ingression. 
  • Pulmonary fibrosis: patterns and perpetrators. 
  • Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. 
  • Repression of mesodermal fate by foxa, a key endoderm regulator of the sea urchin embryo. 
  • Requirement of HDAC6 for transforming growth factor-beta1-induced epithelial-mesenchymal transition. 
  • Retinoic acid receptor alpha function in vertebrate limb skeletogenesis: a modulator of chondrogenesis. 
  • Rhabdomyomatous mesenchymal hamartoma presenting as a sacral skin tag in two neonates with spinal dysraphism. 
  • Role for ETS domain transcription factors Pea3/Erm in mouse lung development. 
  • Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men. 
  • Roles for Fgf signaling during zebrafish fin regeneration. 
  • SHP-2 is required for the maintenance of cardiac progenitors. 
  • SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. 
  • STRIP1, a core component of STRIPAK complexes, is essential for normal mesoderm migration in the mouse embryo. 
  • Sclero-cornea and defective mesodermal migration. 
  • Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. 
  • Sequence and expression of zebrafish foxc1a and foxc1b, encoding conserved forkhead/winged helix transcription factors. 
  • Sequential expression of germ-layer specific molecules in the sea urchin embryo. 
  • Skeletal pattern is specified autonomously by the primary mesenchyme cells in sea urchin embryos. 
  • Skin-derived precursors differentiate into skeletogenic cell types and contribute to bone repair. 
  • Smad5 induces ventral fates in Xenopus embryo. 
  • Sonic hedgehog from pharyngeal arch 1 epithelium is necessary for early mandibular arch cell survival and later cartilage condensation differentiation. 
  • SpHnf6, a transcription factor that executes multiple functions in sea urchin embryogenesis. 
  • Spatially restricted patterns of expression of the homeobox-containing gene Hox 2.1. during mouse embryogenesis. 
  • Specification of chondrocytes and cartilage tissues from embryonic stem cells. 
  • Specification of endoderm and mesoderm in the sea urchin. 
  • Syntaxin 1A is transiently expressed in fetal lung mesenchymal cells: potential developmental roles. 
  • TBX3 Directs Cell-Fate Decision toward Mesendoderm. 
  • Target recognition by the archenteron during sea urchin gastrulation. 
  • Telomere dysfunction causes alveolar stem cell failure. 
  • The DVR gene family in embryonic development. 
  • The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction. 
  • The Snail repressor is required for PMC ingression in the sea urchin embryo. 
  • The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development. 
  • The control of foxN2/3 expression in sea urchin embryos and its function in the skeletogenic gene regulatory network. 
  • The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate. 
  • The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus. 
  • The mammalian class 3 PI3K (PIK3C3) is required for early embryogenesis and cell proliferation. 
  • The organizer factors Chordin and Noggin are required for mouse forebrain development. 
  • The origin of spicule-forming cells in a 'primitive' sea urchin (Eucidaris tribuloides) which appears to lack primary mesenchyme cells. 
  • The regulation of primary mesenchyme cell migration in the sea urchin embryo: transplantations of cells and latex beads. 
  • The role of Brachyury (T) during gastrulation movements in the sea urchin Lytechinus variegatus. 
  • The role of the forkhead transcription factor, Foxc1, in the development of the mouse lacrimal gland. 
  • The role of thin filopodia in motility and morphogenesis. 
  • The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo. 
  • Tissue interactions and estrogenic response during human female fetal reproductive tract development. 
  • Tissue interactions pattern the mesenchyme of the embryonic mouse lung. 
  • Two embryonic, tissue-specific molecules identified by a double-label immunofluorescence technique for monoclonal antibodies. 
  • UG4 enhancer-driven GATA-2 and bone morphogenetic protein 4 complementation remedies the CAKUT phenotype in Gata2 hypomorphic mutant mice. 
  • Vascular-mesenchymal cross-talk through Vegf and Pdgf drives organ patterning. 
  • Wnt2 coordinates the commitment of mesoderm to hematopoietic, endothelial, and cardiac lineages in embryoid bodies. 
  • Zebrafish second heart field development relies on progenitor specification in anterior lateral plate mesoderm and nkx2.5 function. 
  • alphaSU2, an epithelial integrin that binds laminin in the sea urchin embryo. 
  • beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds. 
  • p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis. 
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  Keywords of People

  • Abbruzzese, James, D. C. I. Professor of Medical Oncology, Medicine, Medical Oncology
  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Hilton, Matthew James, Associate Professor in Orthopaedic Surgery, Cell Biology
  • Hogan, Brigid L. M., George Barth Geller Professor, Cell Biology
  • McCall, Shannon Jones, Associate Professor of Pathology, Pathology
  • Wray, Gregory Allan, Professor of Biology, Duke Innovation & Entrepreneurship