Metalloendopeptidases

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  Subject Areas on Research

  • A plasma membrane-associated component of ovarian adenocarcinoma cells enhances the catalytic efficiency of matrix metalloproteinase-2. 
  • Activation mechanisms of the precursors of matrix metalloproteinases 1, 2 and 3. 
  • Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing. 
  • Animals lacking endothelin-converting enzyme-2 are deficient in learning and memory. 
  • Aspartate release from rat hippocampal synaptosomes. 
  • Blockade of endothelin-converting enzyme reduces pulmonary hypertension after cardiopulmonary bypass and circulatory arrest. 
  • Cartilage metalloproteases in disuse atrophy. 
  • Cellular functions of metallo-endoproteinases. 
  • Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice. 
  • Characterization of gelatinases linked to extracellular matrix invasion in ovarian adenocarcinoma: purification of matrix metalloproteinase 2. 
  • Cloning and characterization of a mammalian prenyl protein-specific protease. 
  • Collaborative Angiographic Patency Trial Of Recombinant Staphylokinase (CAPTORS II). 
  • Collaborative angiographic patency trial of recombinant staphylokinase (CAPTORS). 
  • Compromised atrial coronary anatomy is associated with atrial arrhythmias and atrioventricular block complicating acute myocardial infarction. 
  • Contribution of monocytes/macrophages to compensatory neovascularization: the drilling of metalloelastase-positive tunnels in ischemic myocardium. 
  • Contribution of proteases and LasR to the virulence of Pseudomonas aeruginosa during corneal infections. 
  • Corticosteroid treatment and trabecular meshwork proteases in cell and organ culture supernatants. 
  • Degradation of interleukin 1beta by matrix metalloproteinases. 
  • Developmental expression of tissue inhibitor of metalloproteinase (TIMP) RNA. 
  • Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells. 
  • EP24.15 interacts with the angiotensin II type I receptor and bradykinin B2 receptor. 
  • Effect of cisplatin and BCNU on MMP-2 levels in human glioblastoma cell lines in vitro. 
  • Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors. 
  • Embryonic expression of mouse bone morphogenetic protein-1 (BMP-1), which is related to the Drosophila dorsoventral gene tolloid and encodes a putative astacin metalloendopeptidase. 
  • Engraftment of human synovium into severe combined immune deficient mice. Migration of human peripheral blood T cells to engrafted human synovium and to mouse lymph nodes. 
  • Evidence for involvement of metalloendoproteases in a step in sea urchin gamete fusion. 
  • Evidence for preferential adhesion of ovarian epithelial carcinoma cells to type I collagen mediated by the alpha2beta1 integrin. 
  • Evidence for the involvement of metalloendoproteases in the acrosome reaction in sea urchin sperm. 
  • Evolution of the gene encoding mitochondrial intermediate peptidase and its cosegregation with the A mating-type locus of mushroom fungi. 
  • Expression of genes for non-collagenous proteins during embryonic bone formation. 
  • Expression-based assay of an X-linked gene to examine effects of the X-controlling element (Xce) locus. 
  • Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid. 
  • Fatal outcome of bacteraemic patients caused by infection with staphylokinase-deficient Staphylococcus aureus strains. 
  • Gastrointestinal angiodysplasia and aortic stenosis. 
  • Gelatin/chondroitin 6-sulfate microspheres for the delivery of therapeutic proteins to the joint. 
  • IL-1 beta induces COX2, MMP-1, -3 and -13, ADAMTS-4, IL-1 beta and IL-6 in human tendon cells. 
  • Induction of CD4(+) and CD8(+) T-cell responses to the human stromal antigen, fibroblast activation protein: implication for cancer immunotherapy. 
  • Induction of tissue-type plasminogen activator and 72-kDa type-IV collagenase by ionizing radiation in rat astrocytes. 
  • Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition. 
  • Inhibitors of metalloendoproteases block spiculogenesis in sea urchin primary mesenchyme cells. 
  • Interaction of human rheumatoid synovial collagenase (matrix metalloproteinase 1) and stromelysin (matrix metalloproteinase 3) with human alpha 2-macroglobulin and chicken ovostatin. Binding kinetics and identification of matrix metalloproteinase cleavage sites. 
  • Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin. 
  • Kinetics and physiologic relevance of the inactivation of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, and antithrombin III by matrix metalloproteinases-1 (tissue collagenase), -2 (72-kDa gelatinase/type IV collagenase), and -3 (stromelysin). 
  • Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts. Purification and activation of the precursor and enzymic properties. 
  • Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9. 
  • Matrix metalloproteinases and their inhibitors in human vitreous. 
  • Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures. 
  • Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin). 
  • Mice deficient in endothelin-converting enzyme-2 exhibit abnormal responses to morphine and altered peptide levels in the spinal cord. 
  • Monitoring changes in gene expression in renal ischemia-reperfusion in the rat. 
  • Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion. 
  • Novel therapies for pancreatic adenocarcinoma. 
  • Parvalbumin Interneurons of the Mouse Nucleus Accumbens are Required For Amphetamine-Induced Locomotor Sensitization and Conditioned Place Preference. 
  • RFLP detected by an X-linked cDNA encoding erythroid-potentiating activity/tissue inhibitor of metalloproteinase (EPA/TIMP). 
  • Rat myoblast fusion requires metalloendoprotease activity. 
  • Receptors for maleylated proteins regulate secretion of neutral proteases by murine macrophages. 
  • Reconstitution of mitochondrial processing peptidase from the core proteins (subunits I and II) of bovine heart mitochondrial cytochrome bc(1) complex. 
  • Regional localization of the TIMP gene on the human X chromosome. Extension of a conserved synteny and linkage group on proximal Xp. 
  • Regulation and action of the bacterial enhancer-binding protein AAA+ domains. 
  • Renin-angiotensin system gene expression in post-transplant hypertension predicts allograft function. 
  • Requirement for metalloendoprotease in exocytosis: evidence in mast cells and adrenal chromaffin cells. 
  • SP75 is encoded by the DP87 gene and belongs to a family of modular Dictyostelium discoideum outer layer spore coat proteins. 
  • Screen and identification of proteins interacting with ADAM19 cytoplasmic tail. 
  • Secretion of extracellular matrix-degrading proteinases is increased in epithelial ovarian carcinoma. 
  • Specific blockers of myoblast fusion inhibit a soluble and not the membrane-associated metalloendoprotease in myoblasts. 
  • Specific inhibitors implicate a soluble metalloendoproteinase in exocytosis. 
  • Stepwise activation mechanisms of the precursors of matrix metalloproteinases 1 (tissue collagenase) and 3 (stromelysin). 
  • Stromelysin-3 is overexpressed by stromal elements in primary non-small cell lung cancers and regulated by retinoic acid in pulmonary fibroblasts. 
  • Stromelysin-3 suppresses tumor cell apoptosis in a murine model. 
  • Structural remodelling in heart failure: gelatinase induction. 
  • Substrate specificities and activation mechanisms of matrix metalloproteinases. 
  • Suppressor and activator functions mediated by a repeated heptad sequence in the liver fatty acid-binding protein gene (Fabpl). Effects on renal, small intestinal, and colonic epithelial cell gene expression in transgenic mice. 
  • The chromosomal region containing pab-1, mip, and the A mating type locus of the secondarily homothallic homobasidiomycete Coprinus bilanatus. 
  • The effect of enzymatically degradable poly(ethylene glycol) hydrogels on smooth muscle cell phenotype. 
  • The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal septation and positioning of the heart. 
  • The role of cytokines in posttraumatic arthritis. 
  • The role of matrix metalloproteinase 3 in the stepwise activation of human rheumatoid synovial procollagenase. 
  • The soluble metalloendoprotease required in myoblast fusion remains intracellular. 
  • Two distinct forms of soluble MHC class I molecules synthesized by different mechanisms in normal rat cells in vitro. 
  • Type 2 angiotensin II receptor expression in human renal allografts: an association with chronic allograft nephropathy. 
  • Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme. 
  • X chromosome inactivation of the human TIMP gene. 
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  Keywords of People

  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor of Immunology, Cell Biology
  • Toth, Cynthia Ann, Joseph A.C. Wadsworth Distinguished Professor of Ophthalmology, Biomedical Engineering