Metallothionein

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  Subject Areas on Research

  • A cysteine-rich nuclear protein activates yeast metallothionein gene transcription. 
  • ACE1 regulates expression of the Saccharomyces cerevisiae metallothionein gene. 
  • ACE1 transcription factor produced in Escherichia coli binds multiple regions within yeast metallothionein upstream activation sequences. 
  • ACE1, a copper-dependent transcription factor, activates expression of the yeast copper, zinc superoxide dismutase gene. 
  • ACE2, an activator of yeast metallothionein expression which is homologous to SWI5. 
  • Activation of the Saccharomyces cerevisiae heat shock transcription factor under glucose starvation conditions by Snf1 protein kinase. 
  • Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake. 
  • Application of a modified 203Hg binding assay for metallothionein. 
  • BCNU-sequestration by metallothioneins may contribute to resistance in a medulloblastoma cell line. 
  • Biological monitoring for occupational cadmium exposure: the urinary metallothionein. 
  • Characterization of a human squamous carcinoma cell line resistant to cis-diamminedichloroplatinum(II). 
  • Chemistry and biology of copper-chelatin. 
  • Clara cell secretory protein deficiency increases oxidant stress response in conducting airways. 
  • Comparison of gene expression profiles induced by coarse, fine, and ultrafine particulate matter. 
  • Conservation of a stress response: human heat shock transcription factors functionally substitute for yeast HSF. 
  • Copper ion inducible and repressible promoter systems in yeast. 
  • Copper-induced binding of cellular factors to yeast metallothionein upstream activation sequences. 
  • Cryptococcus neoformans Iron-Sulfur Protein Biogenesis Machinery Is a Novel Layer of Protection against Cu Stress. 
  • Cryptococcus neoformans copper detoxification machinery is critical for fungal virulence. 
  • Dynamic regulation of copper uptake and detoxification genes in Saccharomyces cerevisiae. 
  • Enhanced growth of small bowel in transgenic mice overexpressing bovine growth hormone. 
  • Expression of a yeast metallothionein gene family is activated by a single metalloregulatory transcription factor. 
  • Expression of alcohol-inducible rabbit liver cytochrome P-450 3a (P-450IIE1) in Saccharomyces cerevisiae with the copper-inducible CUP1 promoter. 
  • Fine ambient particles induce oxidative stress and metal binding genes in human alveolar macrophages. 
  • Full characterization of the Cu-, Zn-, and Cd-binding properties of CnMT1 and CnMT2, two metallothioneins of the pathogenic fungus Cryptococcus neoformans acting as virulence factors. 
  • Function and autoregulation of yeast copperthionein. 
  • Function and regulation of yeast copperthionein. 
  • Gene copy-number variation in haploid and diploid strains of the yeast Saccharomyces cerevisiae. 
  • Growth inhibition and metallothionein induction in cadmium-resistant cells by essential and non-essential metals. 
  • Heat shock element architecture is an important determinant in the temperature and transactivation domain requirements for heat shock transcription factor. 
  • Heat shock transcription factor activates transcription of the yeast metallothionein gene. 
  • Heat shock transcription factor activates yeast metallothionein gene expression in response to heat and glucose starvation via distinct signalling pathways. 
  • Identification and analysis of a Saccharomyces cerevisiae copper homeostasis gene encoding a homeodomain protein. 
  • Inflammatory and antioxidant gene expression in C57BL/6J mice after lethal and sublethal ozone exposures. 
  • Inhibition of LPS toxicity for macrophages by metallothionein-inducing agents. 
  • Isolation of a metal-activated transcription factor gene from Candida glabrata by complementation in Saccharomyces cerevisiae. 
  • Mammalian metallothionein is functional in yeast. 
  • Marginal zinc deficiency in older adults: responsiveness of zinc status indicators. 
  • Megalin mediates renal uptake of heavy metal metallothionein complexes. 
  • Mercury-induced cognitive impairment in metallothionein-1/2 null mice. 
  • Metal-induced formation of metallothionein in rat liver. 
  • Metal-responsive transcription factor (MTF-1) handles both extremes, copper load and copper starvation, by activating different genes. 
  • Metallothionein abrogates GTP cyclohydrolase I inhibition-induced cardiac contractile and morphological defects: role of mitochondrial biogenesis. 
  • Metallothionein alleviates cardiac dysfunction in streptozotocin-induced diabetes: role of Ca2+ cycling proteins, NADPH oxidase, poly(ADP-Ribose) polymerase and myosin heavy chain isozyme. 
  • Metallothionein alleviates glutathione depletion-induced oxidative cardiomyopathy in murine hearts. 
  • Metallothionein expression and neurocognitive function in mice. 
  • Metallothionein in the central nervous system: Roles in protection, regeneration and cognition. 
  • Mitogens stimulate the rapid nuclear to cytosolic translocation of tristetraprolin, a potential zinc-finger transcription factor. 
  • Oxidative stress induced heat shock factor phosphorylation and HSF-dependent activation of yeast metallothionein gene transcription. 
  • Persisting neurobehavioral effects of developmental copper exposure in wildtype and metallothionein 1 and 2 knockout mice. 
  • Primary structure and tissue-specific expression of blue crab (Callinectes sapidus) metallothionein isoforms. 
  • Properties of Mitotic and Meiotic Recombination in the Tandemly-Repeated CUP1 Gene Cluster in the Yeast Saccharomyces cerevisiae. 
  • Rapid transcriptional autoregulation of a yeast metalloregulatory transcription factor is essential for high-level copper detoxification. 
  • Relative promoter activity in human mammary epithelial cells assayed by transient expression. 
  • Selected contribution: a three-dimensional model for assessment of in vitro toxicity in balaena mysticetus renal tissue. 
  • Stable production of an analog of human tissue plasminogen activator from cultured Drosophila cells. 
  • Stressed-out podocytes in diabetes? 
  • Structures of naturally evolved CUP1 tandem arrays in yeast indicate that these arrays are generated by unequal nonhomologous recombination. 
  • Studies on the zinc content of Cd-induced thionein. 
  • Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. 
  • Tandemly duplicated upstream control sequences mediate copper-induced transcription of the Saccharomyces cerevisiae copper-metallothionein gene. 
  • The Candida glabrata Amt1 copper-sensing transcription factor requires Swi/Snf and Gcn5 at a critical step in copper detoxification. 
  • The acute promyelocytic leukemia PML-RAR alpha protein induces hepatic preneoplastic and neoplastic lesions in transgenic mice. 
  • The interaction of nitric oxide (NO) with the yeast transcription factor Ace1: A model system for NO-protein thiol interactions with implications to metal metabolism. 
  • The prognostic value of molecular marker analysis in patients treated with trimodality therapy for esophageal cancer. 
  • Toxic metal-responsive gene transcription. 
  • Yeast and mammalian metallothioneins functionally substitute for yeast copper-zinc superoxide dismutase. 
  • Yeast metallothionein gene expression in response to metals and oxidative stress. 
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  Keywords of People

  • Hirschey, Matthew, Associate Professor, Pharmacology & Cancer Biology